MCID: OTL001
MIFTS: 27

Outlet Dysfunction Constipation

Categories: Gastrointestinal diseases

Aliases & Classifications for Outlet Dysfunction Constipation

MalaCards integrated aliases for Outlet Dysfunction Constipation:

Name: Outlet Dysfunction Constipation 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2088
ICD9CM 34 564.02
ICD10 32 K59.02
UMLS 71 C0949134

Summaries for Outlet Dysfunction Constipation

MalaCards based summary : Outlet Dysfunction Constipation is related to constipation and extrahepatic cholestasis, and has symptoms including constipation An important gene associated with Outlet Dysfunction Constipation is APOLD1 (Apolipoprotein L Domain Containing 1), and among its related pathways/superpathways are Statin Pathway - Generalized, Pharmacokinetics and Serotonergic synapse. The drugs Diazepam and Gastrointestinal Agents have been mentioned in the context of this disorder.

Related Diseases for Outlet Dysfunction Constipation

Diseases related to Outlet Dysfunction Constipation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 constipation 26.5 SLC6A4 PPIG HTR3A FGFR4 FGF19 CYP3A4
2 extrahepatic cholestasis 10.3 FGFR4 FGF19 CYP7A1
3 hypochondriasis 10.2 SLC6A4 HTR3A
4 bronchiectasis 3 10.2 LCT CYP3A4
5 psychosexual disorder 10.2 SLC6A4 CYP2D6
6 multiple chemical sensitivity 10.0 SLC6A4 CYP2D6 CYP2C19
7 mental depression 10.0 SLC6A4 HTR3A CYP2D6
8 hypotonia 10.0
9 generalized anxiety disorder 10.0 SLC6A4 HTR3A CYP2D6
10 delusional disorder 10.0 CYP2D6 BCHE
11 cocaine abuse 10.0 SLC6A4 HTR3A BCHE
12 brunner syndrome 9.9 SLC6A4 HTR3A
13 neonatal abstinence syndrome 9.9 CYP3A4 CYP2D6
14 acetaminophen metabolism 9.9 CYP3A4 CYP2D6 CYP2C19
15 gastroparesis 9.9 HTR3A CYP3A4 CYP2D6
16 angiodysplasia 9.9 ATP4A ATP12A
17 vagus nerve disease 9.8 ATP4A ATP12A
18 hemangioma of intra-abdominal structure 9.8 ATP4A ATP12A
19 acquired gastric outlet stenosis 9.8 ATP4A ATP12A
20 displacement of cardia through esophageal hiatus 9.8 ATP4A ATP12A
21 benzylpenicillin allergy 9.8 ATP4A ATP12A
22 penicillin allergy 9.8 ATP4A ATP12A
23 granulomatous gastritis 9.8 ATP4A ATP12A
24 bacterial esophagitis 9.8 ATP4A ATP12A
25 lingual goiter 9.8 ATP4A ATP12A
26 cascade stomach 9.8 ATP4A ATP12A
27 gastrojejunal ulcer 9.8 ATP4A ATP12A
28 median arcuate ligament syndrome 9.8 ATP4A ATP12A
29 laryngeal tuberculosis 9.8 ATP4A ATP12A
30 fungal esophagitis 9.8 ATP4A ATP12A
31 esophagus melanoma 9.8 ATP4A ATP12A
32 emphysematous cholecystitis 9.8 ATP4A ATP12A
33 necrotizing gastritis 9.8 ATP4A ATP12A
34 cervix erosion 9.8 ATP4A ATP12A
35 pneumatosis cystoides intestinalis 9.8 ATP4A ATP12A
36 gastric gastrinoma 9.8 ATP4A ATP12A
37 superior mesenteric artery syndrome 9.8 ATP4A ATP12A
38 chronic laryngitis 9.8 ATP4A ATP12A
39 laryngitis 9.8 ATP4A ATP12A
40 cefuroxime allergy 9.8 ATP4A ATP12A
41 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP4A ATP12A
42 chronic intestinal vascular insufficiency 9.8 ATP4A ATP12A
43 peptic ulcer perforation 9.8 ATP4A ATP12A
44 blind loop syndrome 9.8 ATP4A ATP12A
45 acute laryngitis 9.8 ATP4A ATP12A
46 gastroduodenitis 9.8 ATP4A ATP12A
47 duodenitis 9.8 ATP4A ATP12A
48 duodenal gastrinoma 9.8 ATP4A ATP12A
49 gastric hemangioma 9.8 ATP4A ATP12A
50 pancreatic gastrinoma 9.8 ATP4A ATP12A

Graphical network of the top 20 diseases related to Outlet Dysfunction Constipation:



Diseases related to Outlet Dysfunction Constipation

Symptoms & Phenotypes for Outlet Dysfunction Constipation

UMLS symptoms related to Outlet Dysfunction Constipation:


constipation

Drugs & Therapeutics for Outlet Dysfunction Constipation

Drugs for Outlet Dysfunction Constipation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
2 Gastrointestinal Agents Phase 4
3 Anesthetics Phase 4
4 Hypnotics and Sedatives Phase 4
5 Psychotropic Drugs Phase 4
6 Neurotransmitter Agents Phase 4
7 Anti-Anxiety Agents Phase 4
8 Antiemetics Phase 4
9 Anesthetics, General Phase 4
10 GABA Modulators Phase 4
11 Anticonvulsants Phase 4
12 Anesthetics, Intravenous Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rectal Versus Oral Diazepam Administration in the Treatment of Levator Ani Syndrome in Participants Who Have Not Responded to Physical Therapy Treatment: A Prospective Randomized Study Recruiting NCT04216797 Phase 4 Diazepam Tablets
2 Biofeedback for Fecal Incontinence and Constipation Completed NCT00127257 Diazepam

Search NIH Clinical Center for Outlet Dysfunction Constipation

Genetic Tests for Outlet Dysfunction Constipation

Anatomical Context for Outlet Dysfunction Constipation

Publications for Outlet Dysfunction Constipation

Articles related to Outlet Dysfunction Constipation:

# Title Authors PMID Year
1
Gender differences in self-reported constipation characteristics, symptoms, and bowel and dietary habits among patients attending a specialty clinic for constipation. 61
19467522 2009
2
Outlet Dysfunction Constipation. 61
11469987 2001

Variations for Outlet Dysfunction Constipation

Expression for Outlet Dysfunction Constipation

Search GEO for disease gene expression data for Outlet Dysfunction Constipation.

Pathways for Outlet Dysfunction Constipation

Pathways related to Outlet Dysfunction Constipation according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CYP3A4 CYP2D6 CYP2C19
2 11.62 SLC6A4 HTR3A CYP2D6 CYP2C19
3
Show member pathways
11.51 CYP3A4 CYP2D6 CYP2C19
4
Show member pathways
11.47 SLC6A4 CYP3A4 CYP2D6 CYP2C19
5
Show member pathways
11.42 CYP3A4 CYP2D6 CYP2C19
6 11.25 KLB FGFR4 FGF19
7
Show member pathways
11.14 CYP3A4 CYP2D6 CYP2C19
8
Show member pathways
11.03 CYP3A4 CYP2D6 CYP2C19
9
Show member pathways
10.91 SLC6A4 BCHE
10 10.73 CYP7A1 CYP3A4
11 10.41 FGF19 CYP7A1 CYP3A4
12
Show member pathways
10 HTR3A CYP3A4 CYP2D6

GO Terms for Outlet Dysfunction Constipation

Cellular components related to Outlet Dysfunction Constipation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.07 SLC6A4 LCT KLB HTR3A FGFR4 CYP7A1
2 integral component of membrane GO:0016021 9.9 SLC6A4 LCT KLB HTR3A FGFR4 CYP7A1
3 endoplasmic reticulum GO:0005783 9.28 LCT KLB FGFR4 CYP7A1 CYP3A4 CYP2D6
4 organelle membrane GO:0031090 9.26 CYP7A1 CYP3A4 CYP2D6 CYP2C19

Biological processes related to Outlet Dysfunction Constipation according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.67 CYP7A1 CYP3A4 CYP2D6
2 xenobiotic metabolic process GO:0006805 9.65 CYP3A4 CYP2D6 CYP2C19
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.63 KLB FGFR4 FGF19
4 steroid metabolic process GO:0008202 9.62 CYP7A1 CYP3A4 CYP2D6 CYP2C19
5 long-chain fatty acid biosynthetic process GO:0042759 9.58 CYP3A4 CYP2D6
6 organic acid metabolic process GO:0006082 9.58 CYP2D6 CYP2C19
7 estrogen metabolic process GO:0008210 9.57 CYP3A4 CYP2D6
8 cellular sodium ion homeostasis GO:0006883 9.56 ATP4A ATP12A
9 oxidative demethylation GO:0070989 9.55 CYP3A4 CYP2D6
10 sodium ion export across plasma membrane GO:0036376 9.54 ATP4A ATP12A
11 cellular potassium ion homeostasis GO:0030007 9.52 ATP4A ATP12A
12 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.51 ATP4A ATP12A
13 drug catabolic process GO:0042737 9.43 CYP3A4 CYP2D6
14 exogenous drug catabolic process GO:0042738 9.43 CYP3A4 CYP2D6 CYP2C19
15 regulation of bile acid biosynthetic process GO:0070857 9.4 FGFR4 CYP7A1
16 alkaloid catabolic process GO:0009822 9.37 CYP3A4 CYP2D6
17 drug metabolic process GO:0017144 9.33 CYP3A4 CYP2D6 CYP2C19
18 heterocycle metabolic process GO:0046483 9.13 CYP3A4 CYP2D6 CYP2C19
19 monoterpenoid metabolic process GO:0016098 8.8 CYP3A4 CYP2D6 CYP2C19

Molecular functions related to Outlet Dysfunction Constipation according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.71 CYP7A1 CYP3A4 CYP2D6 CYP2C19
2 iron ion binding GO:0005506 9.67 CYP7A1 CYP3A4 CYP2D6 CYP2C19
3 aromatase activity GO:0070330 9.52 CYP3A4 CYP2C19
4 fibroblast growth factor receptor binding GO:0005104 9.51 KLB FGF19
5 fibroblast growth factor binding GO:0017134 9.49 KLB FGFR4
6 serotonin binding GO:0051378 9.48 SLC6A4 HTR3A
7 sodium:potassium-exchanging ATPase activity GO:0005391 9.46 ATP4A ATP12A
8 monooxygenase activity GO:0004497 9.46 CYP7A1 CYP3A4 CYP2D6 CYP2C19
9 potassium-transporting ATPase activity GO:0008556 9.43 ATP4A ATP12A
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.43 CYP3A4 CYP2D6 CYP2C19
11 potassium:proton exchanging ATPase activity GO:0008900 9.32 ATP4A ATP12A
12 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP7A1 CYP3A4 CYP2D6 CYP2C19
13 steroid hydroxylase activity GO:0008395 8.92 CYP7A1 CYP3A4 CYP2D6 CYP2C19

Sources for Outlet Dysfunction Constipation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....