MCID: OVR003
MIFTS: 25

Ovarian Angiosarcoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Angiosarcoma

MalaCards integrated aliases for Ovarian Angiosarcoma:

Name: Ovarian Angiosarcoma 12 15 74
Hemangiosarcoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4527
NCIt 51 C5232
UMLS 74 C1335152

Summaries for Ovarian Angiosarcoma

Disease Ontology : 12 An ovary sarcoma that is a malignant vascular tumor that derives from blood vessels.

MalaCards based summary : Ovarian Angiosarcoma, also known as hemangiosarcoma of ovary, is related to angiosarcoma and kaposiform hemangioendothelioma. An important gene associated with Ovarian Angiosarcoma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). Affiliated tissues include ovary, myeloid and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovarian Angiosarcoma

Graphical network of the top 20 diseases related to Ovarian Angiosarcoma:



Diseases related to Ovarian Angiosarcoma

Symptoms & Phenotypes for Ovarian Angiosarcoma

GenomeRNAi Phenotypes related to Ovarian Angiosarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.17 CD34
2 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.17 MYC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.17 CD34 MYC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.17 MYC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.17 CD34
6 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.17 MYC

Drugs & Therapeutics for Ovarian Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Ovarian Angiosarcoma

Genetic Tests for Ovarian Angiosarcoma

Anatomical Context for Ovarian Angiosarcoma

MalaCards organs/tissues related to Ovarian Angiosarcoma:

42
Ovary, Myeloid, T Cells

Publications for Ovarian Angiosarcoma

Articles related to Ovarian Angiosarcoma:

(show all 14)
# Title Authors Year
1
Pediatric ovarian angiosarcoma treated with systemic chemotherapy and cytoreductive surgery with heated intraperitoneal chemotherapy: Case report and review of therapy. ( 30977252 )
2019
2
Pediatric Primary Ovarian Angiosarcoma: From Rarity to a Realization. ( 30179666 )
2018
3
Bilateral ovarian angiosarcoma arising from the mature cystic teratomas - A case report and review of the literature. ( 29227858 )
2018
4
Primary ovarian angiosarcoma in a 12- year -old girl: a case report of an exceptional localization in a context of limited resources country. ( 28852325 )
2017
5
A metastatic ovarian angiosarcoma mimicking hematologic neoplasia at diagnosis. ( 24847252 )
2014
6
Complete response after MAID treatment for advanced primary ovarian angiosarcoma: case report and literature review. ( 24984551 )
2014
7
Gemcitabine-based regimen for primary ovarian angiosarcoma with MYC amplification. ( 25489268 )
2014
8
Ovarian angiosarcoma: a case report and review of the literature. ( 24520828 )
2014
9
Ovarian angiosarcoma: Extended survival following optimal cytoreductive surgery and adjuvant chemotherapy. ( 24371666 )
2012
10
Primary ovarian angiosarcoma--review of the literature and report of a case with coexisting chylothorax. ( 17713094 )
2007
11
Primary ovarian angiosarcoma presenting as malignant cells in ascites: case report and review of the literature. ( 15830366 )
2005
12
Primary ovarian angiosarcoma: a case report and literature review. ( 9952341 )
1998
13
Diffuse alveolar hemorrhage caused by lung metastasis of ovarian angiosarcoma. ( 8894742 )
1996
14
Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin. ( 8188092 )
1994

Variations for Ovarian Angiosarcoma

Expression for Ovarian Angiosarcoma

Search GEO for disease gene expression data for Ovarian Angiosarcoma.

Pathways for Ovarian Angiosarcoma

Pathways related to Ovarian Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 CD34 PECAM1
2 11.12 CD34 PECAM1
3 10.52 CD34 MYC

GO Terms for Ovarian Angiosarcoma

Cellular components related to Ovarian Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CD34 PECAM1
2 cell periphery GO:0071944 8.62 CD34 PECAM1

Biological processes related to Ovarian Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.26 CD34 MYC
2 negative regulation of gene expression GO:0010629 9.16 CD34 MYC
3 leukocyte migration GO:0050900 8.96 CD34 PECAM1
4 glomerular endothelium development GO:0072011 8.62 CD34 PECAM1

Molecular functions related to Ovarian Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.62 CD34 MYC

Sources for Ovarian Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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