MCID: OVR041
MIFTS: 29

Ovarian Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Benign Neoplasm

MalaCards integrated aliases for Ovarian Benign Neoplasm:

Name: Ovarian Benign Neoplasm 12 15
Benign Ovarian Neoplasm 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0060112

Summaries for Ovarian Benign Neoplasm

Disease Ontology : 12 A female reproductive organ benign neoplasm that is located in the ovary.

MalaCards based summary : Ovarian Benign Neoplasm, also known as benign ovarian neoplasm, is related to ovarian cystadenoma and luteoma. An important gene associated with Ovarian Benign Neoplasm is DES (Desmin), and among its related pathways/superpathways are Glucose / Energy Metabolism and Metabolism of steroid hormones. The drugs Kava and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include the ovary, ovary and lymph node, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Ovarian Benign Neoplasm

Diseases related to Ovarian Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 ovarian cystadenoma 32.0 FH SELE
2 luteoma 32.0 CYP19A1 STAR
3 ovarian brenner tumor 31.7 KRT7 UPK3A
4 ovarian gonadoblastoma 11.2
5 ovarian serous adenofibroma 11.2
6 ovarian endometrioid adenofibroma 11.2
7 cystadenofibroma 11.2
8 ovarian clear cell adenofibroma 11.2
9 mixed epithelial tumor of ovary 11.2
10 ovarian mucinous adenofibroma 11.2
11 parachordoma 10.3 DES KRT7
12 chordoma 10.3 DES KRT7
13 horner's syndrome 10.3 DES KRT7
14 spindle cell sarcoma 10.3 DES KRT7
15 cutaneous leiomyosarcoma 10.3 DES FH
16 leiomyosarcoma 10.3 DES FH
17 mucinous ovarian cystadenoma 10.2 FH KRT7
18 spindle cell carcinoma 10.2 DES KRT7
19 cavernous hemangioma 10.2 DES KRT7
20 uterine sarcoma 10.1 CYP19A1 DES
21 ovary adenocarcinoma 10.1 KRT7 ZNF217
22 carcinosarcoma 10.1 DES KRT7
23 leydig cell tumor 10.1 CYP19A1 STAR
24 ovarian clear cell carcinoma 10.1 KRT7 ZNF217
25 acute contagious conjunctivitis 10.1 CYP19A1 FH
26 sex cord-gonadal stromal tumor 10.1 CYP19A1 KRT7
27 reproductive organ benign neoplasm 10.1 CYP19A1 FH
28 cell type benign neoplasm 10.1 FH KRT7
29 ovarian cancer 1 10.1 KRT7 ZNF217
30 malignant ovarian surface epithelial-stromal neoplasm 10.1 KRT7 ZNF217
31 ovary epithelial cancer 10.1 KRT7 ZNF217
32 sarcoma, synovial 10.1 DES KRT7
33 cystadenocarcinoma 10.1 KRT7 ZNF217
34 ovarian cancer 10.0
35 renal pelvis transitional cell carcinoma 10.0 KRT7 UPK3A
36 glandular cystitis 10.0 KRT7 UPK3A
37 benign metastasizing leiomyoma 10.0 CYP19A1 DES KRT7
38 vulval paget's disease 10.0 KRT7 UPK3A
39 vulvar disease 10.0 KRT7 UPK3A
40 chronic cystitis 10.0 KRT7 UPK3A
41 vulva adenocarcinoma 10.0 KRT7 UPK3A
42 renal pelvis carcinoma 10.0 KRT7 UPK3A
43 urethral diverticulum 10.0 KRT7 UPK3A
44 leiomyoma 10.0 CYP19A1 DES FH
45 lipoid congenital adrenal hyperplasia 10.0 CYP19A1 STAR
46 vulva cancer 10.0 KRT7 UPK3A
47 renal cell carcinoma, papillary, 1 10.0 FH KRT7
48 endometrial stromal sarcoma 9.9 CYP19A1 DES SELE
49 ovarian epithelial cancer 9.9
50 premature ovarian failure 1 9.8 CYP19A1 STAR

Graphical network of the top 20 diseases related to Ovarian Benign Neoplasm:



Diseases related to Ovarian Benign Neoplasm

Symptoms & Phenotypes for Ovarian Benign Neoplasm

GenomeRNAi Phenotypes related to Ovarian Benign Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 DES FH KRT7 SELE STAR

MGI Mouse Phenotypes related to Ovarian Benign Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 CYP19A1 DES FANCF FH KRT7 SELE

Drugs & Therapeutics for Ovarian Benign Neoplasm

Drugs for Ovarian Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Kava Approved, Investigational, Nutraceutical Not Applicable 9000-38-8
2 Hemostatics Not Applicable
3 Coagulants Not Applicable
4 Hormones
5 Hormones, Hormone Substitutes, and Hormone Antagonists
6 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Antiadhesive Barrier GUARDIX-FL for Women After Laparoscopic Cystectomy Unknown status NCT02097446 Phase 3
2 Efficacy Study of FloSeal in Hemostasis After Laparoscopic Ovarian Cystectomy Unknown status NCT01683877 Not Applicable
3 The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH) Unknown status NCT00928044
4 Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor Completed NCT03779399
5 Lavage of the Uterine Cavity for the Diagnosis of Ovarian and Tubal Carcinoma - Study of Sensitivity and Specificity Recruiting NCT02518256 Not Applicable
6 Venous Thromboembolic Complications in Ovarian Cancer Active, not recruiting NCT02480790
7 Oocyte Freezing for Fertility Preservation in Benign Ovarian Tumors Not yet recruiting NCT03823833

Search NIH Clinical Center for Ovarian Benign Neoplasm

Genetic Tests for Ovarian Benign Neoplasm

Anatomical Context for Ovarian Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Benign Neoplasm:

20
The Ovary

MalaCards organs/tissues related to Ovarian Benign Neoplasm:

42
Ovary, Lymph Node

Publications for Ovarian Benign Neoplasm

Articles related to Ovarian Benign Neoplasm:

# Title Authors Year
1
Sclerosing stromal tumour--a rare ovarian benign neoplasm: description of three cases. ( 11820573 )
2001
2
Cholesterol granulomas in lymph nodes draining a benign ovarian neoplasm. ( 3840989 )
1985

Variations for Ovarian Benign Neoplasm

Expression for Ovarian Benign Neoplasm

Search GEO for disease gene expression data for Ovarian Benign Neoplasm.

Pathways for Ovarian Benign Neoplasm

GO Terms for Ovarian Benign Neoplasm

Biological processes related to Ovarian Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid biosynthetic process GO:0006694 9.16 CYP19A1 STAR
2 estrogen biosynthetic process GO:0006703 8.96 CYP19A1 STAR
3 testosterone biosynthetic process GO:0061370 8.62 CYP19A1 STAR

Sources for Ovarian Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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