MCID: OVR045
MIFTS: 27

Ovarian Clear Cell Adenofibroma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Clear Cell Adenofibroma

MalaCards integrated aliases for Ovarian Clear Cell Adenofibroma:

Name: Ovarian Clear Cell Adenofibroma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5897
NCIt 50 C40085
UMLS 70 C1518694

Summaries for Ovarian Clear Cell Adenofibroma

Disease Ontology : 12 An ovarian benign neoplasm that is characterized by the presence of serous fluid and has material basis in glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards based summary : Ovarian Clear Cell Adenofibroma is related to clear cell adenofibroma and clear cell adenocarcinoma. An important gene associated with Ovarian Clear Cell Adenofibroma is NAPSA (Napsin A Aspartic Peptidase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Focal Adhesion. Affiliated tissues include lung, thyroid and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Clear Cell Adenofibroma

Diseases in the Ovarian Clear Cell Adenofibroma family:

Ovarian Clear Cell Malignant Adenofibroma

Diseases related to Ovarian Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 clear cell adenofibroma 30.7 PIK3CA NAPSA
2 clear cell adenocarcinoma 30.2 PIK3CA NAPSA
3 adenocarcinoma 29.2 PTEN PIK3CA NAPSA KRAS
4 ovarian clear cell cystadenofibroma 11.3
5 adenofibroma 10.4
6 endometriosis 10.3
7 clear cell adenocarcinoma of the ovary 10.1
8 overgrowth syndrome 10.1
9 thyroid hurthle cell adenoma 10.0 PTEN PIK3CA
10 vulvar disease 10.0 PTEN PIK3CA
11 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.0 PTEN PIK3CA
12 hemimegalencephaly 10.0 PTEN PIK3CA
13 lung oat cell carcinoma 10.0 PTEN PIK3CA
14 endocervical carcinoma 10.0 PIK3CA NAPSA
15 ovarian clear cell adenocarcinoma 10.0 PIK3CA NAPSA
16 uterine corpus endometrial carcinoma 10.0 PTEN PIK3CA
17 proteus syndrome 10.0 PTEN PIK3CA
18 vulva cancer 10.0 PTEN PIK3CA
19 bilateral breast cancer 10.0 PTEN PIK3CA
20 in situ carcinoma 9.9 PTEN PIK3CA
21 uterine carcinosarcoma 9.9 PTEN PIK3CA
22 suppression of tumorigenicity 12 9.9 PTEN PIK3CA
23 small cell cancer of the lung 9.9 PTEN PIK3CA
24 giant cell glioblastoma 9.9 PTEN PIK3CA
25 mucinous lung adenocarcinoma 9.9 NAPSA KRAS
26 ductal carcinoma in situ 9.9 PTEN PIK3CA
27 serrated polyposis syndrome 9.9 PTEN KRAS
28 papillary adenoma 9.9 NAPSA KRAS
29 thyroid carcinoma 9.9 PTEN PIK3CA
30 skin papilloma 9.9 PTEN KRAS
31 cystic teratoma 9.9 PTEN KRAS
32 teratoma 9.9 PTEN KRAS
33 uterine benign neoplasm 9.9 PTEN KRAS
34 reproductive organ benign neoplasm 9.9 PTEN KRAS
35 gastric cancer, hereditary diffuse 9.9 PTEN KRAS
36 cardiovascular organ benign neoplasm 9.8 PTEN KRAS
37 adenosquamous lung carcinoma 9.8 PIK3CA KRAS
38 liposarcoma 9.8 PTEN PIK3CA
39 ethmoid sinus adenocarcinoma 9.8 PIK3CA KRAS
40 oculoectodermal syndrome 9.8 PIK3CA KRAS
41 small cell carcinoma 9.8 PTEN KRAS
42 eccrine papillary adenoma 9.8 PIK3CA KRAS
43 endometrial adenocarcinoma 9.8 PTEN KRAS
44 cervical adenocarcinoma 9.8 PTEN KRAS
45 anus cancer 9.8 PIK3CA KRAS
46 endometrial hyperplasia 9.8 PTEN KRAS
47 rectum adenocarcinoma 9.8 PIK3CA KRAS
48 arteriovenous malformation 9.8 PTEN KRAS
49 thyroid gland anaplastic carcinoma 9.8 PTEN PIK3CA
50 schimmelpenning-feuerstein-mims syndrome 9.8 PIK3CA KRAS

Graphical network of the top 20 diseases related to Ovarian Clear Cell Adenofibroma:



Diseases related to Ovarian Clear Cell Adenofibroma

Symptoms & Phenotypes for Ovarian Clear Cell Adenofibroma

GenomeRNAi Phenotypes related to Ovarian Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.62 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.62 KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.62 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 9.62 PTEN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.62 KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.62 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.62 KRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.62 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-196 9.62 KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 KRAS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.62 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.62 KRAS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.62 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-45 9.62 NAPSA
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.62 KRAS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.62 KRAS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.62 KRAS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.62 KRAS NAPSA
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-93 9.62 KRAS

Drugs & Therapeutics for Ovarian Clear Cell Adenofibroma

Search Clinical Trials , NIH Clinical Center for Ovarian Clear Cell Adenofibroma

Genetic Tests for Ovarian Clear Cell Adenofibroma

Anatomical Context for Ovarian Clear Cell Adenofibroma

MalaCards organs/tissues related to Ovarian Clear Cell Adenofibroma:

40
Lung, Thyroid, Ovary, Skin, Colon, Breast, Myeloid

Publications for Ovarian Clear Cell Adenofibroma

Articles related to Ovarian Clear Cell Adenofibroma:

# Title Authors PMID Year
1
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. 61
29551085 2018
2
Napsin A is a specific marker for ovarian clear cell adenocarcinoma. 61
24721826 2015
3
Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. 61
28861185 2012
4
Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. 61
21479128 2011
5
Ovarian clear cell adenofibroma of borderline malignancy. A case report. 61
2793520 1989

Variations for Ovarian Clear Cell Adenofibroma

Expression for Ovarian Clear Cell Adenofibroma

Search GEO for disease gene expression data for Ovarian Clear Cell Adenofibroma.

Pathways for Ovarian Clear Cell Adenofibroma

Pathways related to Ovarian Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 PTEN PIK3CA KRAS
2
Show member pathways
12.62 PTEN PIK3CA KRAS
3
Show member pathways
12.58 PTEN PIK3CA KRAS
4
Show member pathways
12.56 PTEN PIK3CA KRAS
5 12.55 PTEN PIK3CA KRAS
6
Show member pathways
12.51 PTEN PIK3CA KRAS
7
Show member pathways
12.48 PTEN PIK3CA KRAS
8
Show member pathways
12.47 PTEN PIK3CA KRAS
9
Show member pathways
12.43 PTEN PIK3CA KRAS
10
Show member pathways
12.41 PTEN PIK3CA KRAS
11
Show member pathways
12.38 PTEN PIK3CA KRAS
12
Show member pathways
12.3 PTEN PIK3CA KRAS
13
Show member pathways
12.28 PTEN PIK3CA KRAS
14 12.23 PTEN PIK3CA KRAS
15
Show member pathways
12.18 PTEN PIK3CA KRAS
16
Show member pathways
12.16 PTEN PIK3CA KRAS
17
Show member pathways
12.14 PTEN PIK3CA KRAS
18
Show member pathways
12.1 PTEN PIK3CA KRAS
19
Show member pathways
12.05 PTEN PIK3CA KRAS
20 11.97 PTEN PIK3CA KRAS
21
Show member pathways
11.93 PTEN PIK3CA KRAS
22 11.8 PTEN PIK3CA KRAS
23 11.79 PIK3CA KRAS
24
Show member pathways
11.76 PTEN PIK3CA KRAS
25 11.75 PTEN KRAS
26
Show member pathways
11.74 PTEN PIK3CA
27
Show member pathways
11.73 PIK3CA KRAS
28 11.7 PIK3CA KRAS
29
Show member pathways
11.68 PTEN PIK3CA KRAS
30 11.66 PTEN PIK3CA
31
Show member pathways
11.66 PIK3CA KRAS
32 11.65 PTEN PIK3CA
33
Show member pathways
11.64 PIK3CA KRAS
34 11.63 PTEN PIK3CA KRAS
35
Show member pathways
11.6 PIK3CA KRAS
36 11.54 PIK3CA KRAS
37 11.52 PIK3CA KRAS
38 11.51 PIK3CA KRAS
39 11.51 PTEN PIK3CA KRAS
40 11.49 PIK3CA KRAS
41 11.48 PTEN PIK3CA
42 11.46 PIK3CA KRAS
43 11.39 PTEN PIK3CA KRAS
44 11.37 PTEN PIK3CA
45 11.37 PTEN PIK3CA
46 11.22 PTEN PIK3CA
47 11.16 PIK3CA KRAS
48 10.98 PIK3CA KRAS
49 10.98 PTEN PIK3CA KRAS
50 10.28 PTEN PIK3CA KRAS

GO Terms for Ovarian Clear Cell Adenofibroma

Biological processes related to Ovarian Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 9.4 PTEN KRAS
2 liver development GO:0001889 9.37 PIK3CA KRAS
3 phosphatidylinositol biosynthetic process GO:0006661 9.32 PTEN PIK3CA
4 protein kinase B signaling GO:0043491 9.26 PTEN PIK3CA
5 phosphatidylinositol 3-kinase signaling GO:0014065 9.16 PTEN PIK3CA
6 endothelial cell migration GO:0043542 8.96 PTEN PIK3CA
7 regulation of synaptic transmission, GABAergic GO:0032228 8.62 PTEN KRAS

Sources for Ovarian Clear Cell Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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