Ovarian Clear Cell Adenofibroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OVR045 MIFTS: 27	Ovarian Clear Cell Adenofibroma Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Ovarian Clear Cell Adenofibroma

MalaCards integrated aliases for Ovarian Clear Cell Adenofibroma:

Name: Ovarian Clear Cell Adenofibroma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5897

NCIt ⁵⁰ C40085

UMLS ⁷⁰ C1518694

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Summaries for Ovarian Clear Cell Adenofibroma

Disease Ontology : ¹² An ovarian benign neoplasm that is characterized by the presence of serous fluid and has material basis in glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards based summary : Ovarian Clear Cell Adenofibroma is related to clear cell adenofibroma and clear cell adenocarcinoma. An important gene associated with Ovarian Clear Cell Adenofibroma is NAPSA (Napsin A Aspartic Peptidase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Focal Adhesion. Affiliated tissues include lung, thyroid and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Ovarian Clear Cell Adenofibroma

Diseases in the Ovarian Clear Cell Adenofibroma family:

Ovarian Clear Cell Malignant Adenofibroma

Diseases related to Ovarian Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)

#	Related Disease	Score	Top Affiliating Genes
1	clear cell adenofibroma	30.7	PIK3CA NAPSA
2	clear cell adenocarcinoma	30.2	PIK3CA NAPSA
3	adenocarcinoma	29.2	PTEN PIK3CA NAPSA KRAS
4	ovarian clear cell cystadenofibroma	11.3
5	adenofibroma	10.4
6	endometriosis	10.3
7	clear cell adenocarcinoma of the ovary	10.1
8	overgrowth syndrome	10.1
9	thyroid hurthle cell adenoma	10.0	PTEN PIK3CA
10	vulvar disease	10.0	PTEN PIK3CA
11	congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	10.0	PTEN PIK3CA
12	hemimegalencephaly	10.0	PTEN PIK3CA
13	lung oat cell carcinoma	10.0	PTEN PIK3CA
14	endocervical carcinoma	10.0	PIK3CA NAPSA
15	ovarian clear cell adenocarcinoma	10.0	PIK3CA NAPSA
16	uterine corpus endometrial carcinoma	10.0	PTEN PIK3CA
17	proteus syndrome	10.0	PTEN PIK3CA
18	vulva cancer	10.0	PTEN PIK3CA
19	bilateral breast cancer	10.0	PTEN PIK3CA
20	in situ carcinoma	9.9	PTEN PIK3CA
21	uterine carcinosarcoma	9.9	PTEN PIK3CA
22	suppression of tumorigenicity 12	9.9	PTEN PIK3CA
23	small cell cancer of the lung	9.9	PTEN PIK3CA
24	giant cell glioblastoma	9.9	PTEN PIK3CA
25	mucinous lung adenocarcinoma	9.9	NAPSA KRAS
26	ductal carcinoma in situ	9.9	PTEN PIK3CA
27	serrated polyposis syndrome	9.9	PTEN KRAS
28	papillary adenoma	9.9	NAPSA KRAS
29	thyroid carcinoma	9.9	PTEN PIK3CA
30	skin papilloma	9.9	PTEN KRAS
31	cystic teratoma	9.9	PTEN KRAS
32	teratoma	9.9	PTEN KRAS
33	uterine benign neoplasm	9.9	PTEN KRAS
34	reproductive organ benign neoplasm	9.9	PTEN KRAS
35	gastric cancer, hereditary diffuse	9.9	PTEN KRAS
36	cardiovascular organ benign neoplasm	9.8	PTEN KRAS
37	adenosquamous lung carcinoma	9.8	PIK3CA KRAS
38	liposarcoma	9.8	PTEN PIK3CA
39	ethmoid sinus adenocarcinoma	9.8	PIK3CA KRAS
40	oculoectodermal syndrome	9.8	PIK3CA KRAS
41	small cell carcinoma	9.8	PTEN KRAS
42	eccrine papillary adenoma	9.8	PIK3CA KRAS
43	endometrial adenocarcinoma	9.8	PTEN KRAS
44	cervical adenocarcinoma	9.8	PTEN KRAS
45	anus cancer	9.8	PIK3CA KRAS
46	endometrial hyperplasia	9.8	PTEN KRAS
47	rectum adenocarcinoma	9.8	PIK3CA KRAS
48	arteriovenous malformation	9.8	PTEN KRAS
49	thyroid gland anaplastic carcinoma	9.8	PTEN PIK3CA
50	schimmelpenning-feuerstein-mims syndrome	9.8	PIK3CA KRAS

Graphical network of the top 20 diseases related to Ovarian Clear Cell Adenofibroma:

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Symptoms & Phenotypes for Ovarian Clear Cell Adenofibroma

GenomeRNAi Phenotypes related to Ovarian Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

²⁶ (show all 19)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-11	9.62	KRAS
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	9.62	KRAS
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-145	9.62	KRAS
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-152	9.62	PTEN
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-165	9.62	KRAS
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-168	9.62	KRAS
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-177	9.62	KRAS
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-193	9.62	KRAS
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-196	9.62	KRAS
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-216	9.62	KRAS
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-23	9.62	KRAS
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-27	9.62	KRAS
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-33	9.62	KRAS
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-45	9.62	NAPSA
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-49	9.62	KRAS
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-50	9.62	KRAS
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	9.62	KRAS
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-66	9.62	KRAS NAPSA
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-93	9.62	KRAS

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Drugs & Therapeutics for Ovarian Clear Cell Adenofibroma

Search Clinical Trials , NIH Clinical Center for Ovarian Clear Cell Adenofibroma

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Genetic Tests for Ovarian Clear Cell Adenofibroma

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Anatomical Context for Ovarian Clear Cell Adenofibroma

MalaCards organs/tissues related to Ovarian Clear Cell Adenofibroma:

⁴⁰

Lung, Thyroid, Ovary, Skin, Colon, Breast, Myeloid

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Publications for Ovarian Clear Cell Adenofibroma

Articles related to Ovarian Clear Cell Adenofibroma:

#	Title	Authors	PMID	Year
1	Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. ⁶¹	Yin Z...Heller D	29551085	2018
2	Napsin A is a specific marker for ovarian clear cell adenocarcinoma. ⁶¹	Yamashita Y...Takahashi S	24721826	2015
3	Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. ⁶¹	Cakir E...Nurkabul Z	28861185	2012
4	Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. ⁶¹	Zhao C...Barner R	21479128	2011
5	Ovarian clear cell adenofibroma of borderline malignancy. A case report. ⁶¹	Katsube Y...Fujiwara A	2793520	1989

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Genes for Ovarian Clear Cell Adenofibroma

Genes related to Ovarian Clear Cell Adenofibroma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	6.41	DISEASES inferred ¹⁵
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3.71	DISEASES inferred ¹⁵
3	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3.24	DISEASES inferred ¹⁵
4	PTEN	Phosphatase And Tensin Homolog	Protein Coding	3.2	DISEASES inferred ¹⁵

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Variations for Ovarian Clear Cell Adenofibroma

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Expression for Ovarian Clear Cell Adenofibroma

Search GEO for disease gene expression data for Ovarian Clear Cell Adenofibroma.

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Pathways for Ovarian Clear Cell Adenofibroma

Pathways related to Ovarian Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 50)

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.7	PTEN PIK3CA KRAS
2	Focal Adhesion ³⁶ ¹ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	12.62	PTEN PIK3CA KRAS
3	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.58	PTEN PIK3CA KRAS
4	Regulation of lipid metabolism Insulin signaling-generic cascades ²³ Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²³ Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²³ Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²³ Insulin signaling pathway ³⁶ Transcription Receptor-mediated HIF regulation ²³ Translation Regulation of EIF2 activity ²³ Translation Regulation of EIF4F activity ²³ Translation Insulin regulation of translation ²³	12.56	PTEN PIK3CA KRAS
5	Pathways in cancer ³⁶	12.55	PTEN PIK3CA KRAS
6	Endometrial cancer ³⁶ Show member pathways Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.51	PTEN PIK3CA KRAS
7	IL-9 Signaling Pathways ⁶⁴ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁴ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Development Thrombopoietin-regulated cell processes ²³ IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ Immune response IL-9 signaling pathway ²³	12.48	PTEN PIK3CA KRAS
8	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.47	PTEN PIK3CA KRAS
9	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.43	PTEN PIK3CA KRAS
10	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.41	PTEN PIK3CA KRAS
11	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.38	PTEN PIK3CA KRAS
12	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.3	PTEN PIK3CA KRAS
13	Immune response Fc epsilon RI pathway ²³ Show member pathways Fc epsilon RI signaling pathway ³⁶ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²³ VEGF signaling pathway ³⁶	12.28	PTEN PIK3CA KRAS
14	MicroRNAs in cancer ³⁶	12.23	PTEN PIK3CA KRAS
15	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	12.18	PTEN PIK3CA KRAS
16	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.16	PTEN PIK3CA KRAS
17	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.14	PTEN PIK3CA KRAS
18	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways T Cell Receptor Signaling Pathway ⁶⁶	12.1	PTEN PIK3CA KRAS
19	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.05	PTEN PIK3CA KRAS
20	Human T-cell leukemia virus 1 infection ³⁶	11.97	PTEN PIK3CA KRAS
21	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	11.93	PTEN PIK3CA KRAS
22	Cellular senescence (KEGG) ³⁶	11.8	PTEN PIK3CA KRAS
23	Thyroid hormone signaling pathway ³⁶	11.79	PIK3CA KRAS
24	Development EGFR signaling via small GTPases ²³ Show member pathways Development EGFR signaling via PIP3 ²³ Development PDGF signaling via MAPK cascades ²³ PDGF Pathway ¹	11.76	PTEN PIK3CA KRAS
25	Glioblastoma Multiforme ⁶³	11.75	PTEN KRAS
26	Insulin resistance ³⁶ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.74	PTEN PIK3CA
27	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	11.73	PIK3CA KRAS
28	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.7	PIK3CA KRAS
29	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.68	PTEN PIK3CA KRAS
30	Small cell lung cancer ³⁶	11.66	PTEN PIK3CA
31	Signaling by Ligand-Responsive EGFR Variants in Cancer ⁶⁵ Show member pathways Constitutive Signaling by EGFRvIII ⁶⁵ Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ⁶⁵ Signaling by EGFR in Cancer ⁶⁵ Signaling by EGFRvIII in Cancer ⁶⁵	11.66	PIK3CA KRAS
32	PI3K / Akt Signaling ⁴	11.65	PTEN PIK3CA
33	FGFR1 mutant receptor activation ⁶⁵ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁵ Signaling by FGFR1 in disease ⁶⁵ Signaling by plasma membrane FGFR1 fusions ⁶⁵	11.64	PIK3CA KRAS
34	Autophagy - animal ³⁶	11.63	PTEN PIK3CA KRAS
35	VEGF Pathway (Tocris) ⁶⁹ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.6	PIK3CA KRAS
36	Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	11.54	PIK3CA KRAS
37	TGF-beta Signaling Pathway (sino) ⁶⁶	11.52	PIK3CA KRAS
38	Renal cell carcinoma ³⁶	11.51	PIK3CA KRAS
39	Sphingolipid signaling pathway ³⁶	11.51	PTEN PIK3CA KRAS
40	Acute myeloid leukemia ³⁶	11.49	PIK3CA KRAS
41	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.48	PTEN PIK3CA
42	GnRH secretion ³⁶	11.46	PIK3CA KRAS
43	DNA Damage Response (only ATM dependent) ¹	11.39	PTEN PIK3CA KRAS
44	PDGFR-beta signaling pathway ¹	11.37	PTEN PIK3CA
45	Copper homeostasis ¹	11.37	PTEN PIK3CA
46	Class I PI3K signaling events ¹	11.22	PTEN PIK3CA
47	Aldosterone-regulated sodium reabsorption ³⁶	11.16	PIK3CA KRAS
48	G-protein signaling_K-RAS regulation pathway ²³	10.98	PIK3CA KRAS
49	Central carbon metabolism in cancer ³⁶	10.98	PTEN PIK3CA KRAS
50	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	10.28	PTEN PIK3CA KRAS

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GO Terms for Ovarian Clear Cell Adenofibroma

Biological processes related to Ovarian Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of protein stability	GO:0031647	9.4	PTEN KRAS
2	liver development	GO:0001889	9.37	PIK3CA KRAS
3	phosphatidylinositol biosynthetic process	GO:0006661	9.32	PTEN PIK3CA
4	protein kinase B signaling	GO:0043491	9.26	PTEN PIK3CA
5	phosphatidylinositol 3-kinase signaling	GO:0014065	9.16	PTEN PIK3CA
6	endothelial cell migration	GO:0043542	8.96	PTEN PIK3CA
7	regulation of synaptic transmission, GABAergic	GO:0032228	8.62	PTEN KRAS

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