Ovarian Cyst disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OVR046 MIFTS: 48	Ovarian Cyst Categories: Cancer diseases, Endocrine diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Ovarian Cyst

MalaCards integrated aliases for Ovarian Cyst:

Name: Ovarian Cyst ¹¹ ⁵ ¹⁴ ⁷⁵

Ovarian Cysts ⁵³ ⁴¹ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the genitourinary system

Noninflammatory disorders of female genital tract

Noninflammatory disorders of ovary, fallopian tube and broad ligament

Other and unspecified ovarian cysts

External Ids:

Disease Ontology ¹¹ DOID:5119

ICD9CM ³⁴ 620.2

SNOMED-CT ⁶⁸ 198586000

ICD10 ³¹ N83.2

UMLS ⁷¹ C0029513 C0029927

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Summaries for Ovarian Cyst

MedlinePlus: ⁴¹ The ovaries are part of the female reproductive system. They produce a woman's eggs and make female hormones. Ovarian cysts are fluid-filled sacs in or on an ovary. They usually form during ovulation, when the ovary releases an egg. They are usually harmless and go away by themselves. Most women have them sometime during their lives. Most ovarian cysts are small and don't cause symptoms. Women may not find out that they have them until they have a pelvic exam. If there are symptoms, they may include: Pressure Bloating Swelling Pain in the lower abdomen, on the side where the cyst is If your health care provider finds a cyst, you may be able to wait to see if it gets bigger. You may need surgery if you have pain, are past menopause, or if the cyst does not go away. If a cyst bursts or causes bleeding, you should get medical help right away. Birth control pills can help prevent new cysts. Rarely, ovarian cysts can become cancerous. This risk increases as you get older. A health problem that involves ovarian cysts is polycystic ovary syndrome (PCOS). Women with PCOS can have high levels of male hormones, irregular or no periods, and small ovarian cysts. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary: Ovarian Cyst, also known as ovarian cysts, is related to corpus luteum cyst and dermoid cyst of ovary, and has symptoms including pelvic pain An important gene associated with Ovarian Cyst is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are Integrated breast cancer pathway and Glucocorticoid receptor regulatory network. The drugs Letrozole and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include ovary, b cells and uterus, and related phenotypes are homeostasis/metabolism and neoplasm

Disease Ontology: ¹¹ An ovarian disease that is characterized by the presence of a fluid-filled sac and is located in the ovary.

Wikipedia: ⁷⁵ An ovarian cyst is a fluid-filled sac within the ovary. Often they cause no symptoms. Occasionally they... more...

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Related Diseases for Ovarian Cyst

Diseases in the Ovarian Cyst family:

Malignant Ovarian Cyst

Diseases related to Ovarian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 516)

#	Related Disease	Score	Top Affiliating Genes
1	corpus luteum cyst	32.4	MUC16 GNRH1 AFP
2	dermoid cyst of ovary	30.8	AMH AFP
3	cystadenoma	30.7	MUC16 MUC1 GNAS BRCA1 AFP
4	cystic teratoma	30.5	MUC1 AMH AFP
5	leiomyoma	30.5	GNRH1 ESR2 ESR1 CYP19A1
6	ovarian serous cystadenocarcinoma	30.5	MUC16 MUC1 GNAS BRCA1
7	ectopic pregnancy	30.4	PAEP GNRH1 CGA AMH AFP
8	fibroma	30.4	MUC16 GNAS ESR1
9	leiomyoma, uterine	30.4	GNRH1 ESR2 ESR1 CYP19A1
10	amenorrhea	30.3	SHBG PRL GNRH1 CYP19A1
11	juvenile type testicular granulosa cell tumor	30.3	GNAS AMH AFP
12	teratoma	30.3	MUC1 ESR1 CGA AMH AFP
13	precocious puberty, male-limited	30.2	GNRH1 GNAS CYP19A1 AMH
14	pseudomyxoma peritonei	30.2	MUC16 MUC1 GNAS
15	adenomyosis	30.2	MUC16 ESR1 CYP19A1
16	lipoid congenital adrenal hyperplasia	30.2	SHBG PRL GNRH1 CYP19A1 AMH
17	mucinous ovarian cystadenoma	30.1	WFDC2 AFP
18	adenoma	30.1	PRL MUC1 MSH2 GNAS
19	endometriosis	30.1	PAEP MUC16 GNRH1 ESR2 ESR1 CYP19A1
20	ovarian hyperstimulation syndrome	30.0	SHBG GNRH1 CYP19A1 CGA AMH
21	myoma	30.0	PRL GNRH1 ESR1 CYP19A1 AMH
22	inguinal hernia	30.0	GNRH1 CRP AMH AFP
23	ovarian cystadenoma	30.0	WFDC2 MUC16 BRCA1 AFP
24	pseudohermaphroditism	30.0	GNRH1 CYP19A1 AMH
25	dysgerminoma	30.0	MUC1 BRCA1 AFP
26	pituitary adenoma	29.9	PRL GNRH1 GNAS CNC2
27	cystadenocarcinoma	29.9	MUC16 MUC1 ESR2 BRCA1
28	pituitary tumors	29.9	PRL GNAS CNC2
29	tuberculous peritonitis	29.9	MUC16 CRP AFP
30	hyperandrogenism	29.9	SHBG PRL GNRH1 CYP19A1 AMH
31	premature ovarian failure 1	29.9	PRL GNRH1 AMH
32	endosalpingiosis	29.9	ESR1 BRCA1
33	obstructive jaundice	29.9	MUC16 CRP AFP
34	abdominal tuberculosis	29.9	CRP AFP
35	vaginal discharge	29.8	GNRH1 ESR1 CYP19A1 CRP
36	endometrial hyperplasia	29.8	MSH2 ESR2 ESR1 CYP19A1
37	pituitary gland disease	29.7	PRL GNRH1 GNAS CGA
38	serous cystadenocarcinoma	29.7	MUC16 MSH2 ESR1 BRCA1
39	congenital hypothyroidism	29.7	SHBG PRL GNAS AFP
40	wilms tumor 1	29.7	MUC1 ESR1 BRCA1 AFP
41	female breast cancer	29.6	ESR2 ESR1 CYP19A1 BRCA1
42	endometriosis of ovary	29.6	GNRH1 ESR2 ESR1 CYP19A1 AMH
43	testicular torsion	29.6	SHBG CRP AMH AFP
44	insulin-like growth factor i	29.6	SHBG PRL IGFBP2 ESR1
45	colon adenocarcinoma	29.6	GNAS ESR2 ESR1 CEACAM7
46	ovarian cystadenocarcinoma	29.6	MUC16 MUC1 GNAS ESR1 BRCA1
47	ovary adenocarcinoma	29.6	MUC16 MUC1 GNAS ESR1 BRCA1
48	acne	29.5	SHBG PRL CYP19A1 CRP
49	hyperprolactinemia	29.5	SHBG PRL GNRH1 GNAS CGA
50	hypothyroidism	29.5	SHBG PRL GNRH1 GNAS CRP CGA

Graphical network of the top 20 diseases related to Ovarian Cyst:

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Symptoms & Phenotypes for Ovarian Cyst

UMLS symptoms related to Ovarian Cyst:

pelvic pain

MGI Mouse Phenotypes related to Ovarian Cyst:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.24	AFP AMH BRCA1 CEACAM7 CGA CRP
2	neoplasm	MP:0002006	10.16	AFP AMH BRCA1 ESR1 ESR2 GNAS
3	normal	MP:0002873	10.09	BRCA1 CEACAM7 CYP19A1 ESR1 ESR2 GNAS
4	liver/biliary system	MP:0005370	10.06	AFP CYP19A1 ESR1 ESR2 GNAS GNRH1
5	endocrine/exocrine gland	MP:0005379	10.06	AFP AMH BRCA1 CGA CYP19A1 ESR1
6	immune system	MP:0005387	9.93	BRCA1 CEACAM7 CRP CYP19A1 ESR1 ESR2
7	digestive/alimentary	MP:0005381	9.86	BRCA1 CYP19A1 ESR1 ESR2 GNAS GNRH1
8	reproductive system	MP:0005389	9.65	AFP AMH BRCA1 CGA CYP19A1 ESR1
9	integument	MP:0010771	9.32	BRCA1 CEACAM7 CYP19A1 ESR1 ESR2 GNAS

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Drugs & Therapeutics for Ovarian Cyst

Drugs for Ovarian Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Letrozole

Approved, Investigational

Phase 4

112809-51-5

3902

Etoricoxib

Approved, Investigational

Phase 4

202409-33-4

123619

Danazol

Approved

Phase 4

17230-88-5

28417

Cetrorelix

Approved, Investigational

Phase 4

120287-85-6

25074887

Ganirelix

Approved

Phase 4

124904-93-4

44208957 16186319 16130966

Norethisterone

Approved

Phase 4

68-22-4

199472 6230

Progesterone

Approved, Vet_approved

Phase 4

57-83-0

5994

Analgesics

Phase 4

Estrogen Receptor Antagonists

Phase 4

Estrogen Antagonists

Phase 4

Aromatase Inhibitors

Phase 4

Antirheumatic Agents

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Cyclooxygenase 2 Inhibitors

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Analgesics, Non-Narcotic

Phase 4

Fenugreek seed meal

Phase 4

Fenugreek

Phase 4

Contraceptives, Oral

Phase 4

Contraceptive Agents

Phase 4

Contraceptives, Oral, Hormonal

Phase 4

Norethindrone Acetate

Phase 4

541197

Ethinylestradiol

Approved

Phase 2, Phase 3

57-63-6

5991

Norgestimate

Approved, Investigational

Phase 2, Phase 3

35189-28-7

6540478

Ropivacaine

Approved

Phase 3

84057-95-4

71273 175805

Morphine

Approved, Investigational

Phase 3

57-27-2

5288826

Estradiol

Approved, Investigational, Vet_approved

Phase 3

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 3

28014-46-2

Anesthetics

Phase 3

Anesthetics, Local

Phase 3

Estradiol 3-benzoate

Phase 3

Estradiol 17 beta-cypionate

Phase 3

Contraceptives, Oral, Combined

Phase 3

Hormones

Phase 3

Estrogens

Phase 3

Hormone Antagonists

Phase 3

Progestins

Phase 3

Racephedrine

Approved, Experimental

Phase 1, Phase 2

299-42-3, 90-82-4, 90-81-3

5032 9294 7028

Esmolol

Approved, Withdrawn

Phase 1, Phase 2

103598-03-4, 81147-92-4

59768

Phenylephrine

Approved

Phase 1, Phase 2

59-42-7

6041

Oxymetazoline

Approved, Investigational

Phase 1, Phase 2

1491-59-4

4636

Neurotransmitter Agents

Phase 1, Phase 2

Cardiotonic Agents

Phase 1, Phase 2

Adrenergic beta-Antagonists

Phase 1, Phase 2

Adrenergic beta-1 Receptor Antagonists

Phase 1, Phase 2

Adrenergic Antagonists

Phase 1, Phase 2

Adrenergic alpha-Agonists

Phase 1, Phase 2

Adrenergic Agonists

Phase 1, Phase 2

Adrenergic Agents

Phase 1, Phase 2

Vasoconstrictor Agents

Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 55)

#	Name	Status	NCT ID	Phase	Drugs
1	The Impact on Ovarian Reserve After Single-port, Two-port, or Four-port Access Laparoscopic Ovarian Cyst Enucleation	Unknown status	NCT01631253	Phase 4
2	The Role of Estrogen in Luteinizing Hormone Surge and Ovulation	Completed	NCT01999569	Phase 4	Letrozole
3	The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Exc	Completed	NCT00713778	Phase 4
4	Pain Post Abdominal Laparoscopy Prevention With Arcoxia	Completed	NCT00565682	Phase 4	etoricoxib 120 mg
5	Treatment With Danazol Before Controlled Ovarian Hyperstimulation in Women With Endometriosis Undergoing IVF	Completed	NCT01779232	Phase 4	Danazol;placebo
6	Efficacy and Safety of Furocyst in Patients With Poly Cystic Ovary Syndrome	Completed	NCT02789488	Phase 4
7	A Random Clinical Trial of the Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst	Completed	NCT00746278	Phase 4
8	GnRH Antagonist Pre-treatment in the Early Follicular Phase for Resolution of a Baseline Functional Ovarian Cyst - A Proof-of-concept Pilot Study	Recruiting	NCT04993924	Phase 4	Cetrorelix Acetate, Ganerelix Acetate
9	Randomized Control Trial Between Norethisterone Acetate and Expectant Management in Treatment of Simple Ovarian Cysts	Not yet recruiting	NCT05293574	Phase 4	norethisterone acetate
10	Are the Combined Oral Contraceptive Pills Needed for Management of the Simple Ovarian Cysts in Reproductive Women? (Randomized Controlled Study)	Unknown status	NCT03357640	Phase 2, Phase 3	combined oral contraceptive pills
11	Additional Benefit of Hemostatic Sealant in Preserving Ovarian Reserve During Laparoscopic Ovarian Cystectomy: a Randomized Controlled Trial	Completed	NCT01857466	Phase 3
12	Do Peritoneal Nebulization of Ropivacaine Reduce the Use of Morphine After Short Gynecologic Laparoscopic Surgery?	Completed	NCT01142622	Phase 3	Ropivacaine nebulization;Ropivacaine instillation
13	A Single Center, Randomized, Investigator-initiated Phase III Trial to Evaluate the Efficacy of Preservation of Ovarian Function and Hemostasis, and Its Safety of [email protected] During Laparoscopic Ovarian Cystectomy	Completed	NCT03374397	Phase 3	Surgiguard
14	Single Port Laparoscopy Versus Conventional Laparoscopy for Benign Adnexal Disease - A Randomized Controlled Trial.	Completed	NCT01288599	Phase 3
15	Treatment of Functional Ovarian Cyst Randomised Clinical Trial	Not yet recruiting	NCT05244811	Phase 3	Combined Oral Contraceptive;Progestin
16	A Prospective, Controlled, Randomized, Multi-Center, Pivotal Study Evaluating the Safety and Efficacy of AdhexilTM in Prevention And/Or Reduction of Adhesions in Gynecology Surgery	Suspended	NCT00865488	Phase 3
17	The Effects of ß1-receptor Blockade and α1-adrenergic Agonist on the Kinetics of Lactated Ringer's Solution During Surgery	Completed	NCT01431612	Phase 1, Phase 2	Esmolol administration;Phenylephrine infusion;Lactated Ringer´s solution
18	The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cysts: Randomization Clinical Trial	Unknown status	NCT03585309
19	Monitoring Ovarian Cysts in Pregnancy	Unknown status	NCT03440931
20	A Multicentre Study to Examine the Short and Long Term Outcomes of the Conservative Management of Benign-looking Adnexal Masses and the Pre-operative Characterisation of Ovarian Tumours	Unknown status	NCT01698632
21	A New Algorithm to Predict Ovarian Age Combining Clinical, Biochemical and 3D-ultrasonographic Parameters: OvAge	Unknown status	NCT02086318
22	Prognosis and Long Term Pubertal Outcome of Girls Previously Diagnosed With a Prenatal Ovarian Cyst	Unknown status	NCT02482467
23	The Efficacy of Progestins in Treatment of Functional Ovarian Cyst	Unknown status	NCT03456570	Early Phase 1	Dydrogesterone 10 mg;Placebo Oral Tablet
24	Evaluation and Implementation of New Biomarkers and Algorithms for Diagnosis of Ovarian Cysts/Tumors in the Pelvis	Completed	NCT03193671
25	Comparison Between Abstention and Intrauterine Aspiration in the Treatment of Anechoic Fetal Ovarian Cysts to Prevent Ovarian Torsion	Completed	NCT00222066
26	The Effect of Surgery for Non Endometriosic Ovarian Cysts on Ovarian Reserve : A Prospective Study	Completed	NCT02852447
27	23 Hour Surgical Model in a Tertiary Hospital: Evaluation From Patient and Organisational Perspective	Completed	NCT04142203
28	Retrospective Multi-institutional Survey of Clinical Characteristics in Ovarian Clear Cell Adenocarcinoma Cancer Patients	Completed	NCT02129036
29	The Effect of Laparoscopic Surgery on Ovarian Reserve According to Cyst Types	Completed	NCT05054946
30	Mesial Incision for Laparoscopic Dermoid Cystectomy: a New Safe and Fertility-sparing Technique	Completed	NCT01590030
31	Laparoscopy-assisted Ovarian Cystectomy: NEW APPROCH	Completed	NCT03370952
32	Transvaginal Ultrasound Training for the Obstetrics and Gynecology Resident: A Multi-Site Randomized Controlled Trial of Educational DVD	Completed	NCT02890914
33	Ultrasonographic Evaluation of Ovarian Stroma in PCOS Women	Completed	NCT05418595
34	Therapeutic Role of Flax Seed for Poly Cystic Ovary Syndrome	Completed	NCT03713138
35	To Study the Efficacy and Safety of Furocyst in Poly Cystic Ovary Syndrome Patients (PCOS)	Completed	NCT02703064
36	The Affect of Hemostasis With Bipolar Coagulation Versus SURGIFLO Placement on Ovarian Reserve and Future Fertility	Completed	NCT03109964
37	Comparison of Optic Nerve Sheath Diameter According to Position During Laparoscopy	Completed	NCT01937104		Desflurane;Remifentanil
38	The Effect of Different I:E Ratio on Gas Exchange of Patients Undergoing Gynecologic Laparoscopic Surgery With Trendelenburg Position	Completed	NCT01379313
39	A Prospective, Multi-Centre, Randomized, Safety and Effectiveness Study of PerClot Compared to Usual Care When Used During Gynaecology Procedures	Completed	NCT02835391
40	3-dimensional Versus 2-dimensional Laparoscopy Of Ovarian Cyst (LOOC): a Randomized Controlled Trial	Completed	NCT03453333
41	Diagnosing Ovarian Cysts - the DOC Study	Recruiting	NCT04188652
42	Ultrasound Elastography in Differentiation of Endometriomas and Hemorrhagic Ovarian Cysts	Recruiting	NCT05104086
43	Intra-operative Ultrasound Guided Laparoscopic Ovarian Cystectomy (UGLOC) as a Method of Fertility Preservation in the Management of Benign Ovarian Cysts: Randomised Controlled Trial	Recruiting	NCT05032846
44	Using INDOcyanine Green to Analyse Ovarian Vascularization After Ovarian Laparoscopic CYStectomy	Recruiting	NCT04355312
45	A Pilot Study to Test Rapid Acquisition of Point of Care Ultrasound for Various Applications	Recruiting	NCT02831556
46	Ovarian Cyst's Enucleation Spillage Score. An Observational Study of Cyst Characteristics for Spillage During Laparoscopic Enucleation	Recruiting	NCT05376384
47	Real-Time Identification of Lesions and Nerves by Using Indocyanine Green Fluorescent Imaging in Gynecological Surgery	Recruiting	NCT04224467
48	A Multi-center, Randomized, Investigator-initiated Trial to Evaluate the Efficacy of PRreservation of ovArian Function, Hemostasis, and sAfety of a Hemostatic Agent Versus Suturing During Laparoscopic Ovarian Cystectomy for Endometrioma	Recruiting	NCT04643106
49	Pubertal Evolutionary Profile of Children Monitored for Fetal Ovarian Cyst	Recruiting	NCT04526392
50	Prediction of Malignant Potential of Ovarian Cysts Using Machine Learning Models	Not yet recruiting	NCT05342298

Search NIH Clinical Center for Ovarian Cyst

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Genetic Tests for Ovarian Cyst

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Anatomical Context for Ovarian Cyst

Organs/tissues related to Ovarian Cyst:

FMA: Ovary

MalaCards : Ovary, B Cells, Uterus, Breast, Pituitary, Appendix, Small Intestine

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Publications for Ovarian Cyst

Articles related to Ovarian Cyst:

(show top 50) (show all 5144)

#	Title	Authors	PMID	Year
1	Comparison of immunohistochemical characteristics of endometriomas with non-endometriotic benign ovarian cysts. ⁶² ⁴¹	Cagiran FT...Celik O	36314331	2022
2	Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone. ⁴¹	Pan Y...Shi H	36348508	2022
3	Clinical outcomes of fetal ovarian masses diagnosed by prenatal ultrasonography and literature review. ⁴¹	Min J...Wang J	36254031	2022
4	Reproductive disturbances in multiple neuroendocrine tumor syndromes. ⁵³ ⁶²	Lytras A...Tolis G	19737912	2009
5	Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence. ⁵³ ⁶²	Belgorosky A...Rivarola MA	19844120	2009
6	Precocious pseudopuberty due to autonomous ovarian cysts: a report of ten cases and long-term follow-up. ⁵³ ⁶²	de Sousa G...Andler W	18477555	2008
7	The impact of unabated stimulation by human chorionic gonadotropin on the steroid hormone environment of pregnant rats and the spontaneous expression of ovarian cysts in female progeny. ⁵³ ⁶²	Bogovich K	18481228	2008
8	McCune-Albright syndrome and disorders due to activating mutations of GNAS1. ⁵³ ⁶²	Diaz A...Crawford J	17937059	2007
9	Myxedema ascites with an extremely elevated CA125 Level: a case report. ⁵³ ⁶²	Kanehara H...Tanaka N	17641444	2007
10	Involvement of plasma progesterone, oestradiol-17beta and cortisol in ovulatory response to gonadotropin-releasing hormone in dairy cows with cystic follicles. ⁵³ ⁶²	Isobe N...Yoshimura Y	17635773	2007
11	Obligatory roles for follicle-stimulating hormone (FSH), estradiol and androgens in the induction of small polyfollicular ovarian cysts in hypophysectomized immature rats. ⁵³ ⁶²	Bogovich K	17873331	2007
12	Association between milk production and treatment response of ovarian cysts in lactating dairy cows using the Ovsynch protocol. ⁵³ ⁶²	Crane MB...Archbald LF	16650468	2006
13	Insulin-like growth factor binding protein-2 stimulates proliferation and activates multiple cascades of the mitogen-activated protein kinase pathways in NIH-OVCAR3 human epithelial ovarian cancer cells. ⁵³ ⁶²	Chakrabarty S...Kondratick L	16357519	2006
14	Measurement of glycodelin A in fluids of benign ovarian cysts, borderline tumours and malignant ovarian cancer. ⁵³ ⁶²	Bischof A...Jeschke U	16033074	2005
15	Development of monoclonal and polyclonal antibodies and an ELISA for the determination of glycodelin in human serum, amniotic fluid and cystic fluid of benign and malignant ovarian tumors. ⁵³ ⁶²	Jeschke U...Karsten U	16033064	2005
16	No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome. ⁵³ ⁶²	Soderlund D...Mendez JP	15695318	2005
17	[Carney complex: a case report and literature review]. ⁵³ ⁶²	Almeida MQ...Mendonca BB	15761519	2004
18	Intracystic evaluation of tumor markers in benign and malignant ovarian pathology. ⁵³ ⁶²	Cherchi PL...Dessole S	12013118	2002
19	The development of an oocyte-containing follicle during gonadotrophin-releasing hormone agonist administration. ⁵³ ⁶²	Almagor M...Hovav Y	11473966	2001
20	Factors influencing serum CA125II levels in healthy postmenopausal women. ⁵³ ⁶²	Pauler DK...Jacobs IJ	11352859	2001
21	Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy. ⁵³ ⁶²	Stratakis CA...Carney JA	11095480	2000
22	Serum CA125 at 11-14 weeks of gestation in women with morphologically normal ovaries. ⁵³ ⁶²	Aslam N...Jurkovic D	10826587	2000
23	Synergistic effects of insulin-like growth factor-I and human chorionic gonadotropin in the rat ovary. ⁵³ ⁶²	Damario MA...Poretsky L	10726907	2000
24	Insulin has a biphasic effect on the ability of human chorionic gonadotropin to induce ovarian cysts in the rat. ⁵³ ⁶²	Bogovich K...Poretsky L	10459564	1999
25	Follow up of women with simple ovarian cysts detected by transvaginal sonography in the Tokyo metropolitan area. ⁵³ ⁶²	Sasaki H...Tanaka T	10430190	1999
26	Differential expression of estrogen receptor-alpha and -beta messenger RNAs as a potential marker of ovarian carcinogenesis. ⁵³ ⁶²	Pujol P...Maudelonde T	9850067	1998
27	Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues. ⁵³ ⁶²	Biljan MM...Tan SL	9866068	1998
28	CA-125 and carcinoembryonic antigen assay vs. cytodiagnostic experience in the classification of benign ovarian cysts. ⁵³ ⁶²	Pinto MM...Garfinkel R	9305384	1997
29	[A patient with bronchial asthma and mucoid impaction who presented with a high concentration of carcinoembryonic antigen in serum]. ⁵³ ⁶²	Matsuo K...Hiraki S	9366164	1997
30	Inhibin assays of ovarian cyst liquid obtained by needle aspiration may allow differential diagnosis between functional and organic cysts. ⁵³ ⁶²	Binelli C...Alain D	9228498	1997
31	The behavior of follicle cysts formed after long-acting gonadotropin-releasing hormone analog administration in patients with polycystic ovarian syndrome. ⁵³ ⁶²	Ellenbogen A...Ballas S	9174850	1997
32	The assessment of value of transvaginal ultrasound for monitoring of gestational trophoblastic disease treatment. ⁵³ ⁶²	Bidzinski M...Drabik M	9443032	1997
33	Serum levels of the tumour-associated trypsin inhibitor in patients with endometriosis. ⁵³ ⁶²	Medl M...Leodolter S	8988701	1997
34	Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid. ⁵³ ⁶²	Kanety H...Karasik A	8624265	1996
35	[Hydatidiform mole in Vietnam. The contribution of ultrasonography]. ⁵³ ⁶²	Do DT...Blache G	7899773	1995
36	Persistent elevation of serum oestradiol levels by functional ovarian cysts despite effective pituitary desensitization with GnRH agonists. ⁵³ ⁶²	Jenkins JM...Thomas E	8187299	1994
37	Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats. ⁵³ ⁶²	Poretsky L...Bogovich K	1640871	1992
38	Serous ovarian cyst fluids contain high levels of endometrial placental protein 14. ⁵³ ⁶²	Riittinen L	1626182	1992
39	Circulating hormone concentrations in hypothyroid rats with induced polycystic ovaries. ⁵³ ⁶²	Lee MT...Bruot BC	1924408	1991
40	Effect of intracavitary radiotherapy on tumor-associated trypsin inhibitor (TATI) in patients with cervical and endometrial cancer. ⁵³ ⁶²	Lehtovirta P...Stenman UH	2354815	1990
41	Measurement of CA125, carcinoembryonic antigen, and alpha-fetoprotein in ovarian cyst fluid: diagnostic adjunct to cytology. ⁵³ ⁶²	Pinto MM...Lavy G	1696873	1990
42	A case of endometriotic cyst enlargement during pregnancy owing to desmoplasia and rupture at 36 weeks of gestation. ⁶²	Tanabe S...Morishima S	36439931	2023
43	Recognizing the features of Isolated Fallopian Tube Torsion on CT and MRI and interobserver agreement: A cross-sectional study. ⁶²	Coutureau J...Taourel P	36410090	2022
44	Gangrenous Hydrosalpinx with Isolated Fallopian Tube Torsion in Premenarchal Child. ⁶²	Thomas J...Chirayath S	36457430	2022
45	Claudin-6 enhances the malignant progression of gestational trophoblastic neoplasm by promoting proliferation and metastasis. ⁶²	Wu Q...Wang Y	36471225	2022
46	Acute epiploic appendagitis - a rare differential diagnosis of acute abdomen. ⁶²	Harling L...Meyer F	36470286	2022
47	Atypical Presentation of a Giant Hemorrhagic Ovarian Cyst. ⁶²	Sen S...Srivastava H	36452449	2022
48	Real-world outcomes of the levonorgestrel-releasing intrauterine system for heavy menstrual bleeding or dysmenorrhea in Japanese patients: A prospective observational study (J-MIRAI). ⁶²	Harada T...Hirano K	36057322	2022
49	A curious case of ovarian cysts. ⁶²	Hodges R...Watkins E	36412944	2022
50	A Challenging Case of Fertility Preservation in Metastatic Struma Ovarii in a 29-Year Old With Successful Delivery. ⁶²	Sadath SA...Annal A	36457444	2022

Sources

Genes for Ovarian Cyst

Genes related to Ovarian Cyst (1 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	MSH2	MutS Homolog 2	Protein Coding	404.1	Pathogenic ⁵ DISEASES inferred ¹⁴
2	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	20.41	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1696873 10430190 17641444 (more) 10826587 9228498 11352859
3	AFP	Alpha Fetoprotein	Protein Coding	12.57	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	12.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8187299 18477555 9866068 (more) 11473966 17635773 16650468 9174850
5	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	11.51	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15695318 19844120
6	PAEP	Progestagen Associated Endometrial Protein	Protein Coding	9.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16033074 1626182 16033064
7	GNAS	GNAS Complex Locus	Protein Coding	9.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17937059
8	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Protein Coding	8.78	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8624265 16357519
9	AMH	Anti-Mullerian Hormone	Protein Coding	6.87	DISEASES inferred ¹⁴
10	CEACAM7	CEA Cell Adhesion Molecule 7	Protein Coding	6.75	GeneCards inferred via : Publications (show sections)
11	ESR2	Estrogen Receptor 2	Protein Coding	6.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9850067
12	CNC2	Carney Complex Type 2, Multiple Neoplasia And Lentiginosis	Genetic Locus	6.59	Novoseek inferred ⁵³	19737912 11095480 15761519
13	WFDC2	WAP Four-Disulfide Core Domain 2	Protein Coding	6.27	DISEASES inferred ¹⁴
14	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	6.12	Novoseek inferred ⁵³	17873331 10459564 10726907
15	SHBG	Sex Hormone Binding Globulin	Protein Coding	5.73	DISEASES inferred ¹⁴
16	ESR1	Estrogen Receptor 1	Protein Coding	5.72	DISEASES inferred ¹⁴
17	PRL	Prolactin	Protein Coding	5.48	DISEASES inferred ¹⁴
18	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	5.44	DISEASES inferred ¹⁴
19	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	5.44	DISEASES inferred ¹⁴
20	CRP	C-Reactive Protein	Protein Coding	5.39	DISEASES inferred ¹⁴
21	PGR	Progesterone Receptor	Protein Coding	5.28	DISEASES inferred ¹⁴
22	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.27	DISEASES inferred ¹⁴
23	OR4F15	Olfactory Receptor Family 4 Subfamily F Member 15	Protein Coding	5.23	DISEASES inferred ¹⁴

Sources

Variations for Ovarian Cyst

ClinVar genetic disease variations for Ovarian Cyst:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	MSH2	NM_000251.3(MSH2):c.1226_1227del (p.Gln409fs)	DEL	Pathogenic	90577	rs63750086	GRCh37: 2:47657030-47657031 GRCh38: 2:47429891-47429892

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Expression for Ovarian Cyst

Search GEO for disease gene expression data for Ovarian Cyst.

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Pathways for Ovarian Cyst

Pathways related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Integrated breast cancer pathway ⁷⁴	11.74	MSH2 ESR1 CYP19A1 BRCA1
2	Glucocorticoid receptor regulatory network ⁶¹	11.38	PRL CGA AFP
3	Validated nuclear estrogen receptor alpha network ⁶¹	11.07	PRL ESR2 ESR1 BRCA1
4	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ⁷⁴	10.84	PRL ESR2 ESR1
5	Hormone ligand-binding receptors ⁶⁶	10.45	GNRH1 CGA
6	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.4	ESR2 ESR1 CYP19A1

Sources

GO Terms for Ovarian Cyst

Cellular components related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.98	WFDC2 PRL PAEP MUC16 MUC1 IGFBP2
2	extracellular region	GO:0005576	9.68	AFP AMH CEACAM7 CGA CRP GNAS

Biological processes related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to estrogen	GO:0043627	9.1	IGFBP2 ESR1 BRCA1

Molecular functions related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.76	PRL GNRH1 CGA AMH
2	estrogen response element binding	GO:0034056	9.56	ESR2 ESR1
3	steroid binding	GO:0005496	9.43	SHBG ESR2 ESR1
4	nuclear estrogen receptor activity	GO:0030284	8.92	ESR2 ESR1