Ovarian Cyst disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OVR046 MIFTS: 53	Ovarian Cyst Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Ovarian Cyst

MalaCards integrated aliases for Ovarian Cyst:

Name: Ovarian Cyst ¹² ²⁹ ⁶ ¹⁵

Ovarian Cysts ⁵⁵ ⁴³ ⁴⁴ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the genitourinary system

Noninflammatory disorders of female genital tract

Noninflammatory disorders of ovary, fallopian tube and broad ligament

Other and unspecified ovarian cysts

External Ids:

Disease Ontology ¹² DOID:5119

ICD10 ³³ N83.2

ICD9CM ³⁵ 620.2

MeSH ⁴⁴ D010048

UMLS ⁷³ C0029513 C0029927

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Summaries for Ovarian Cyst

MedlinePlus : ⁴³ The ovaries are part of the female reproductive system. They produce a woman's eggs and make female hormones. Ovarian cysts are fluid-filled sacs in or on an ovary. They usually form during ovulation, when the ovary releases an egg. They are usually harmless and go away by themselves. Most women have them sometime during their lives. Most ovarian cysts are small and don't cause symptoms. Women may not find out that they have them until they have a pelvic exam. If there are symptoms, they may include Pressure Bloating Swelling Pain in the lower abdomen, on the side where the cyst is If your health care provider finds a cyst, you may be able to wait to see if it gets bigger. You may need surgery if you have pain, are past menopause, or if the cyst does not go away. If a cyst bursts or causes bleeding, you should get medical help right away. Birth control pills can help prevent new cysts. Rarely, ovarian cysts can become cancerous. This risk increases as you get older. A health problem that involves ovarian cysts is polycystic ovary syndrome (PCOS). Women with PCOS can have high levels of male hormones, irregular or no periods, and small ovarian cysts. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Ovarian Cyst, also known as ovarian cysts, is related to corpus luteum cyst and ovarian disease, and has symptoms including pelvic pain An important gene associated with Ovarian Cyst is MUC16 (Mucin 16, Cell Surface Associated), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Formation of Fibrin Clot (Clotting Cascade). The drugs Drospirenone and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and uterus, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Disease Ontology : ¹² An ovarian disease that is characterized by the presence of a fluid-filled sac and is located in the ovary.

Wikipedia : ⁷⁶ An ovarian cyst is a fluid-filled sac within the ovary. Often they cause no symptoms. Occasionally they... more...

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Related Diseases for Ovarian Cyst

Diseases in the Ovarian Cyst family:

Malignant Ovarian Cyst

Diseases related to Ovarian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)

#	Related Disease	Score	Top Affiliating Genes
1	corpus luteum cyst	31.9	AFP FOXL2 MUC16
2	ovarian disease	31.4	FOXL2 MUC16 NOBOX PRL VEGFA
3	cystadenocarcinoma	29.7	VEGFA MUC16
4	adenomyosis	29.6	VEGFA PRL
5	neonatal ovarian cyst	12.3
6	malignant ovarian cyst	12.3
7	mccune-albright syndrome	11.4
8	fraser-like syndrome	11.1
9	aromatase deficiency	11.0
10	bleeding disorder, platelet-type, 19	11.0
11	autoimmune oophoritis	11.0
12	lipedematous scalp	11.0
13	ovarian cancer	10.3
14	breast cancer	10.3
15	hypothyroidism	10.2
16	opisthorchiasis	10.2	MUC16 AFP
17	endodermal sinus tumor	10.2	MUC16 AFP
18	endometriosis	10.2
19	juvenile type testicular granulosa cell tumor	10.2	FOXL2 AFP
20	testicular granulosa cell tumor	10.2	FOXL2 AFP
21	hydrocele	10.2	VEGFA AFP
22	male reproductive organ benign neoplasm	10.2	FOXL2 AFP
23	primary peritoneal carcinoma	10.2	VEGFA MUC16
24	peliosis hepatis	10.2	VEGFA AFP
25	telangiectasis	10.2	VEGFA AFP
26	pericardial effusion	10.1	VEGFA MUC16
27	sex cord-gonadal stromal tumor	10.1	FOXL2 AFP
28	placental insufficiency	10.1	VEGFA AFP
29	ovarian brenner tumor	10.1	PRL MUC16
30	serous cystadenocarcinoma	10.1	VEGFA MUC16
31	granulosa cell tumor of the ovary	10.1	PRL FOXL2
32	meningocele	10.1
33	pituitary tumors	10.1	VEGFA PRL
34	intratubular embryonal carcinoma	10.1	PLAU AFP
35	ectopic pregnancy	10.1
36	bile duct disease	10.1	SLC25A13 AFP
37	hyperphenylalaninemia, bh4-deficient, a	10.1	SLC25A13 PRL
38	uterine anomalies	10.0	AFP VEGFA
39	vein disease	10.0	AFP PLAT VEGFA
40	ovarian hyperstimulation syndrome	10.0
41	adenoma	10.0
42	biliary tract disease	10.0	SLC25A13 AFP
43	female reproductive system disease	10.0	VEGFA PRL FOXL2
44	hydronephrosis	10.0
45	leiomyoma	10.0
46	intestinal obstruction	10.0
47	joint disorders	10.0	SERPINB2 PLAU
48	gingivitis	10.0	PLAT SERPINB2
49	lipodermatosclerosis	10.0	PLAT SERPINB2 VEGFA
50	leiomyoma, uterine	9.9

Graphical network of the top 20 diseases related to Ovarian Cyst:

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Symptoms & Phenotypes for Ovarian Cyst

UMLS symptoms related to Ovarian Cyst:

pelvic pain

MGI Mouse Phenotypes related to Ovarian Cyst:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.95	AFP FOXL2 NOBOX PLAT PLAU PRL
2	homeostasis/metabolism	MP:0005376	9.92	AFP FOXL2 PLAT PLAU PRL SERPINB2
3	growth/size/body region	MP:0005378	9.91	FOXL2 NOBOX PLAT PLAU SERPINB2 SLC25A13
4	mortality/aging	MP:0010768	9.76	AFP FOXL2 NOBOX PLAT PLAU SERPINB2
5	liver/biliary system	MP:0005370	9.65	AFP PLAU PRL SLC25A13 VEGFA
6	neoplasm	MP:0002006	9.35	AFP PLAU PRL SERPINB2 VEGFA
7	reproductive system	MP:0005389	9.17	AFP FOXL2 NOBOX PLAT PLAU PRL

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Drugs & Therapeutics for Ovarian Cyst

Drugs for Ovarian Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 380)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Drospirenone

Approved

Phase 4,Phase 3,Phase 1,Not Applicable

67392-87-4

68873

Ethinyl Estradiol

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

57-63-6

5991

Cyproterone Acetate

Approved, Investigational

Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable

427-51-0

Polyestradiol phosphate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

28014-46-2

Estradiol

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-28-2

5757

Estradiol valerate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

979-32-8

Metformin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

657-24-9

14219 4091

Simvastatin

Approved

Phase 4,Phase 3,Not Applicable

79902-63-9

54454

Resveratrol

Approved, Experimental, Investigational

Phase 4,Phase 1,Not Applicable

501-36-0

445154

Ganirelix

Approved

Phase 4,Early Phase 1

123246-29-7, 124904-93-4

25081094

Orlistat

Approved, Investigational

Phase 4,Phase 2

96829-58-2

3034010

Letrozole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

112809-51-5

3902

Pioglitazone

Approved, Investigational

Phase 4,Not Applicable,Early Phase 1

111025-46-8

4829

leucovorin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

58-05-9

6006 143

Acarbose

Approved, Investigational

Phase 4,Not Applicable

56180-94-0

441184

Zinc

Approved, Investigational

Phase 4,Early Phase 1,Not Applicable

7440-66-6

Progesterone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

57-83-0

5994

Hydrocortisone acetate

Approved, Vet_approved

Phase 4,Not Applicable,Early Phase 1

50-03-3

Hydrocortisone

Approved, Vet_approved

Phase 4,Not Applicable,Early Phase 1

50-23-7

5754

Testosterone

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

58-22-0

6013

Danazol

Approved

Phase 4

17230-88-5

28417

Etoricoxib

Approved, Investigational

Phase 4

202409-33-4

123619

Liraglutide

Approved

Phase 4,Phase 3

204656-20-2

44147092

Menotropins

Approved

Phase 4,Phase 1,Phase 2

61489-71-2, 9002-68-0

5360545

Acetylcysteine

Approved, Investigational

Phase 4,Phase 2,Phase 3,Not Applicable

616-91-1

12035

Epinephrine

Approved, Vet_approved

Phase 4,Not Applicable,Early Phase 1

51-43-4

5816

Racepinephrine

Approved

Phase 4,Not Applicable,Early Phase 1

329-65-7

838

Citalopram

Approved

Phase 4

59729-33-8

2771

Alogliptin

Approved

Phase 4

850649-61-5

11450633

Moxonidine

Approved, Investigational

Phase 4

75438-57-2

4810

Nicotinamide

Approved, Investigational

Phase 4

98-92-0

936

Methylcobalamin

Approved, Experimental, Investigational

Phase 4,Not Applicable

13422-55-4

Hydroxocobalamin

Approved

Phase 4,Not Applicable

13422-51-0

11953898 44475014

Leuprolide

Approved, Investigational

Phase 4,Phase 2,Not Applicable,Early Phase 1

53714-56-0

657181 3911

Hyaluronic acid

Approved, Vet_approved

Phase 4,Phase 1,Phase 2

9004-61-9

53477741

Rosiglitazone

Approved, Investigational

Phase 4,Not Applicable

122320-73-4

77999

Exenatide

Approved, Investigational

Phase 4,Phase 3,Phase 2

141758-74-9

15991534

Tamoxifen

Approved

Phase 4,Phase 3

10540-29-1

2733526

tannic acid

Approved

Phase 4,Phase 2,Not Applicable,Early Phase 1

Benzocaine

Approved, Investigational

Phase 4,Phase 2,Not Applicable,Early Phase 1

94-09-7, 1994-09-7

2337

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Not Applicable,Early Phase 1

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Not Applicable,Early Phase 1

50-02-2

5743

Medroxyprogesterone acetate

Approved, Investigational

Phase 4,Not Applicable

71-58-9

Desogestrel

Approved

Phase 4,Phase 3

54024-22-5

40973

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Toremifene

Approved, Investigational

Phase 4

89778-26-7

3005573

Nitrous oxide

Approved, Vet_approved

Phase 4

10024-97-2

948

Interventional clinical trials:

(show top 50) (show all 584)

#	Name	Status	NCT ID	Phase	Drugs
1	The Impact on Ovarian Reserve After Single-port, Two-port, or Four-port Access Laparoscopic Ovarian Cyst Enucleation	Unknown status	NCT01631253	Phase 4
2	Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants	Unknown status	NCT02027337	Phase 4	20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
3	Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients	Unknown status	NCT01246310	Phase 4
4	Metformin in Infertile PCOS Patients	Unknown status	NCT00501904	Phase 4	Metformin
5	the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome	Unknown status	NCT01752270	Phase 4	Diane-35 pretreatment;Diane-35 pretreatment
6	Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients	Unknown status	NCT02766803	Phase 4	Simvastatin and micronized trans-resveratrol
7	Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome	Unknown status	NCT01366391	Phase 4	Metformin
8	Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women	Unknown status	NCT02140398	Phase 4
9	Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients	Unknown status	NCT00417144	Phase 4	Arvekap 0.1mg (Triptorelin, Ipsen, France);Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
10	Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)	Unknown status	NCT00378729	Phase 4	Metformin and FSHr
11	Metformin and Gestational Diabetes in High-risk Patients: a RCTs	Unknown status	NCT00883259	Phase 4	Metformin
12	The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS)	Unknown status	NCT01475019	Phase 4	Orlistat;Sibutramine
13	Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS	Unknown status	NCT00461643	Phase 4	Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
14	The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst	Completed	NCT00713778	Phase 4
15	A Random Clinical Trial (RCT) of the Impact of Electrocoagulation on Ovarian Reserve	Completed	NCT00746278	Phase 4
16	Clinical Evaluation of Furocyst in Patients With Poly Cystic Ovary Syndrome	Completed	NCT02789488	Phase 4
17	The Role of Estrogen in Luteinizing Hormone Surge and Ovulation	Completed	NCT01999569	Phase 4	Letrozole
18	Danazol Treatment in Endometriosis Women Before IVF	Completed	NCT01779232	Phase 4	Danazol;placebo
19	Pain Post Abdominal Laparoscopy Prevention With Arcoxia	Completed	NCT00565682	Phase 4	etoricoxib 120 mg
20	FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women	Completed	NCT02674178	Phase 4
21	Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study	Completed	NCT01021579	Phase 4	Metformin plus Placebo;Metfomin plus Simvastatin
22	The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination	Completed	NCT01219101	Phase 4	clomiphene citrate with ethinyl esteradiol;clomiphene citrate with plasebo
23	Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS	Completed	NCT03644212	Phase 4	Vitamin D3
24	Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance and Type 2 Diabetes in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome	Completed	NCT03122041	Phase 4	Sitagliptin
25	Weight Maintenance With Dipeptidyl Peptidase 4 (DPP4) Inhibitor Sitagliptin in Combination With Metformin After Liragludite Induced Weight Loss	Completed	NCT02941445	Phase 4	sitagliptin and metformin;Metformin
26	The Effect of Metformin on Different Hormones in PCOS Patients	Completed	NCT02568488	Phase 4	Metformin
27	Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome	Completed	NCT02483299	Phase 4	Metformin;Glucophage tablets and Victoza
28	Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS	Completed	NCT02352597	Phase 4	phytoestrogen;estradiol valerate;clomiphene citrate
29	PDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome	Completed	NCT02187250	Phase 4	metformin;liraglutide;roflumilast
30	PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome	Completed	NCT02037672	Phase 4	metformin;metformin and roflumilast
31	Polycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin	Completed	NCT01911468	Phase 4	metformin;liraglutide;metformin and liraglutide
32	Polycystic Ovary Syndrome and Liraglutide	Completed	NCT01899430	Phase 4	liraglutide;metformin
33	Vitamin D Treatment, Pharmacogenetics and Glucose Metabolism	Completed	NCT01721915	Phase 4	Vitamin D supplementation;Placebo
34	Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women	Completed	NCT01675310	Phase 4	medical nutrition therapy + metformin
35	hMG or Recombinant FSH on OHSS Prevention in PCOS Patients Undergoing IVF	Completed	NCT01365936	Phase 4	HMG;rFSH
36	Adding L-Carnitine to Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome	Completed	NCT03630341	Phase 4	Clomiphene Citrate 50mg;L-carnitine;Placebo Oral Tablet
37	The Effect of a Liraglutide on IVF in Obese PCOS	Completed	NCT03353948	Phase 4	MET;COMBI
38	Oral Contraceptive and Cardiovascular Risk in PCOS	Completed	NCT00593294	Phase 4	OC - Drospirenone plus Ethynylestradiol
39	The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS	Completed	NCT02866786	Phase 4	Metformin;ethinyl estradiol and cyproterone acetate
40	Metformin and Oral Contraceptives in PCOS	Completed	NCT00451568	Phase 4	Metformin;Desorelle
41	The Effects of Vitamin D on Angiogenic Factors in Women With Polycystic Ovary Syndrome	Completed	NCT02460380	Phase 4	Vitamin D3
42	Trial With Metformin in Women With Polycystic Ovary Syndrome	Completed	NCT02280057	Phase 4	Metformin;Placebo
43	N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome	Completed	NCT02239107	Phase 4	N-Acetyl cysteine
44	LIPT - Liraglutide in Polycystic Ovary Syndrome	Completed	NCT02073929	Phase 4	Liraglutide;placebo
45	The Effect of Cipralex on Quality of Life, Adrenal Activity Glucose Metabolism, Physical and Mental Health in PCOS	Completed	NCT01961180	Phase 4	Cipralex;Placebo
46	Comparison of Alogliptin Versus Alogliptin and Pioglitazone on Insulin Resistance of Metformin Treated Women With PCOS	Completed	NCT02683226	Phase 4	Vipdomet;Incresync
47	Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome	Completed	NCT01540747	Phase 4
48	Polycystic Ovary Syndrome - Improving Outcomes	Completed	NCT01504321	Phase 4	Moxonidine;Placebo
49	Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism	Completed	NCT01360996	Phase 4	3 mg DRSP/20 μg EE
50	Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS)	Completed	NCT01279512	Phase 4	Metformin;Acarbose

Search NIH Clinical Center for Ovarian Cyst

Cochrane evidence based reviews: ovarian cysts

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Genetic Tests for Ovarian Cyst

Genetic tests related to Ovarian Cyst:

#	Genetic test	Affiliating Genes
1	Ovarian Cyst ²⁹

Sources

Anatomical Context for Ovarian Cyst

MalaCards organs/tissues related to Ovarian Cyst:

⁴¹

Ovary, Pituitary, Uterus, Bone, Kidney, Thyroid, Appendix

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Cyst:

¹⁹

The Ovary

Sources

Publications for Ovarian Cyst

Articles related to Ovarian Cyst:

(show top 50) (show all 1370)

#	Title	Authors	Year
1	The effects of sclerotherapy with 5% trichloroacetic acid on the cyst diameter and ovarian tissue in the rat ovarian cyst model. ( 29564948 )	ArtaA9 G....Akyol A.	2018
2	Vaginal bleeding and a giant ovarian cyst in an infant with 21-hydroxylase deficiency. ( 29252197 )	A9ahin N.M....Aycan Z.	2018
3	Omental fat necrosis without torsion mimicking ovarian cyst torsion. ( 29685724 )	Yi S.W.	2018
4	Ovarian cyst removal influences ovarian reserve dependent on histology, size and type of operation. ( 29806554 )	Henes M....Lawrenz B.	2018
5	A Giant Ovarian Cyst in an Adolescent. ( 29731358 )	Corrias F....Barbi E.	2018
6	High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice. ( 29684361 )	Kuwahara Y...Weissman BE	2018
7	Successful treatment of a giant ovarian cyst by levothyroxin in a young adult woman: A case report. ( 30051551 )	Xie Z...Liao E	2018
8	The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer. ( 30254998 )	Lee S...Lee KS	2018
9	Histological classification of canine ovarian cyst types with reference to medical history. ( 30304884 )	Knauf Y...Wehrend A	2018
10	Fishnet/cobweb ovary: Haemorrhagic ovarian cyst. ( 30309168 )	Xiang H...Ridley LJ	2018
11	High Incidence of Ovarian Cysts in Women Receiving mTOR Inhibitors After Renal Transplantation. ( 29087803 )	Bachmann F...Bachmann C	2018
12	Daughter cyst sign in ovarian cysts. ( 29198005 )	Fonseca EKUN...Sameshima YT	2018
13	In-utero aspiration vs expectant management of anechoic fetal ovarian cysts: open randomized controlled trial. ( 29205608 )	Diguisto C...Perrotin F	2018
14	A retrospective multicenter study of the natural history of fetal ovarian cysts. ( 29534823 )	Tyraskis A...De Coppi P	2018
15	Anti-Müllerian hormone levels and spontaneous pregnancy in women undergoing surgery for benign ovarian cysts. ( 29724140 )	Casadei L...Piccione E	2018
16	Variation in Downstream Relative Costs Associated With Incidental Ovarian Cysts on Ultrasound. ( 29728324 )	Rosenkrantz AB...Nicola GN	2018
17	Diagnostic value of neutrophil to lymphocyte ratio in differentiation of ruptured ovarian cysts and adnexal torsion. ( 29971185 )	Soysal S...Baki RB	2018
18	Re: In-utero aspiration vs expectant management of anechoic fetal ovarian cysts: open randomized controlled trial. C. Diguisto , N. Winer , G. Benoist , H. Laurichesse-Delmas , J. Potin , A. Binet , H. Lardy , B. Morel and F. Perrotin . Ultrasound Obstet Gynecol 2018; 52: 159-164. ( 30095235 )	D'Antonio F	2018
19	The Evaluation of Laparoscopic Surgery on Pregnant Patients with Ovarian Cysts and Its Effects on Pregnancy over the Past 5 Years. ( 30254926 )	Kurihara K...Eto M	2018
20	How long should we follow simple ovarian cysts with pelvic ultrasonography? ( 30289754 )	McNamara MC...Brook R	2018
21	Suggestive hypothesis on a case report: Patient presenting with cyclical ovarian cysts coupled to increased cholestatic enzymes. ( 30393940 )	Conca P...Tarantino G	2018
22	Assessment of Diagnostic Values among CA-125, RMI, HE4, and ROMA for Cancer Prediction in Women with Nonfunctional Ovarian Cysts. ( 30402106 )	Oranratanaphan S...Triratanachat S	2018
23	Impending abdominal compartment syndrome from a giant ovarian cyst torsion. ( 28922702 )	Kim T.J....Zobair K.	2017
24	Case Report of Clitoral Hypertrophy in 2 Extremely Premature Girls With an Ovarian Cyst. ( 28931575 )	NerrAc A.L....Nivot-Adamiak S.	2017
25	Performance of ovarian cyst fluid fine-needle aspiration cytology. ( 28834408 )	Zhou A.G....Vandenbussche C.J.	2017
26	Haemoperitoneum due to ruptured ovarian cyst in a 13-year-old girl with factor V deficiency- A case report. ( 28138193 )	Aslam S.L....Fareeduddin M.	2017
27	Laparoscopic Management of a Giant Ovarian Cyst in a Premenarchal Girl. ( 28104495 )	Hurni Y....Puligheddu C.	2017
28	A Wandering Abdominal Mass in a Neonate: An Enteric Duplication Cyst Mimicking an Ovarian Cyst. ( 28348910 )	Iijima S.	2017
29	Diagnostic accuracy of haptoglobin within ovarian cyst fluid as a potential point-of-care test for epithelial ovarian cancer: an observational study. ( 28755436 )	Mahyuddin A.P....Choolani M.	2017
30	Complete Laparoscopic Extirpation of a Giant Ovarian Cyst in an Adolescent. ( 28840047 )	Baradwan S....Sendy S.	2017
31	Presacral mass in the setting of an ovarian cyst and abdominal pain. ( 28659365 )		2017
32	Enormous Ovarian Cyst. ( 29021455 )		2017
33	Treatment of Recurrent Ovarian Cysts and Primary Infertility by Iranian Traditional Medicine: A Case Report. ( 27932523 )	Salehi M...Mokaberinejad R	2017
34	Papillary Serous Carcinoma of the Peritoneum Mimicking an Ovarian Cyst in Pregnancy. ( 27133555 )	Paul PG...Radhika KT	2017
35	Hemorrhage in a Fetal Ovarian Cyst. ( 28770146 )	Hassan R...Mazlin J	2017
36	Giant ovarian cyst masquerading as a massive ascites: a case report. ( 29258579 )	Yeika EV...Fomengia JN	2017
37	The relationship between functional ovarian cysts and vitamin A, vitamin E, and folate intake. ( 27924658 )	Tafazoli M...Dadgar S	2017
38	Neonatal ovarian cysts: ultrasound assessment and differential diagnosis. ( 28024877 )	Llorens Salvador R...Garc?s I?igo E	2017
39	Age-Specific Frequencies and Characteristics of Ovarian Cysts in Children and Adolescents. ( 28044991 )	Emeksiz HC...Bideci A	2017
40	Management of Complex Ovarian Cysts in Newborns - Our Experience. ( 28083489 )	Manjiri S...Shetty J	2017
41	Evaluation and Treatment Results of Ovarian Cysts in Childhood and Adolescence: A Multicenter, Retrospective Study of 100 Patients. ( 28167139 )	Aydin BK...Darendeliler F	2017
42	The Diagnosis and Management of Ovarian Cysts in Children. ( 28214196 )	Bertozzi M...Appignani A	2017
43	Bilateral Ovarian Torsion during Follow-up for Antenatally Detected Ovarian Cysts. ( 28540192 )	Zupancic B...Habek D	2017
44	Effect of menstrual phase on the surgical treatment of ovarian cysts. ( 28597715 )	Song T...Seong SJ	2017
45	Comparative Gene Expression Analysis of Lymphocytes Treated with Exosomes Derived from Ovarian Cancer and Ovarian Cysts. ( 28620375 )	Li Y...Zhao S	2017
46	Microarray analysis reveals differentially expressed lncRNAs in benign epithelial ovarian cysts and normal ovaries. ( 28656240 )	Liu X...Xu P	2017
47	The presence of ovarian cysts in a captive Antillean manatee (Trichechus manatus manatus L. 1758). ( 28810859 )	Go?dziewska-Har?ajczuk K...Dzimira S	2017
48	A systematic review and meta-analysis on fetal ovarian cysts: impact of size, appearance and prenatal aspiration. ( 28886226 )	Tyraskis A...De Coppi P	2017
49	Outcome of fetal ovarian cysts diagnosed on prenatal ultrasound examination: systematic review and meta-analysis. ( 27325566 )	Bascietto F...D'Antonio F	2017
50	LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer. ( 27941916 )	Wang H....Xu P.	2016

Sources

Genes for Ovarian Cyst

Genes related to Ovarian Cyst (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	24.97	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1696873 10430190 17641444 (more) 10826587 9228498 11352859
2	AFP	Alpha Fetoprotein	Protein Coding	20.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	FOXL2	Forkhead Box L2	Protein Coding	20.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	16.8	GeneCards inferred via : Publications (show sections)
5	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	16.46	GeneCards inferred via : Publications (show sections)
6	PRL	Prolactin	Protein Coding	16.46	GeneCards inferred via : Publications (show sections)
7	SERPINB2	Serpin Family B Member 2	Protein Coding	16.46	GeneCards inferred via : Publications (show sections)
8	PLAU	Plasminogen Activator, Urokinase	Protein Coding	16.46	GeneCards inferred via : Publications (show sections)
9	NOBOX	NOBOX Oogenesis Homeobox	Protein Coding	16.46	GeneCards inferred via : Publications (show sections)
10	SLC25A13	Solute Carrier Family 25 Member 13	Protein Coding	16.46	GeneCards inferred via : Publications (show sections)

Sources

Variations for Ovarian Cyst

Sources

Expression for Ovarian Cyst

Search GEO for disease gene expression data for Ovarian Cyst.

Sources

Pathways for Ovarian Cyst

Pathways related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁷ IRS activation ⁶⁶ Signal attenuation ⁶⁶ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.51	PLAT PLAU SERPINB2 VEGFA
2	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.78	PLAT PLAU SERPINB2
3	Complement and coagulation cascades ¹ ³⁷	11.64	PLAT PLAU SERPINB2
4	Senescence and Autophagy in Cancer ¹	11.46	PLAT PLAU SERPINB2
5	Cell adhesion_ECM remodeling ²²	11.26	PLAT PLAU
6	amb2 Integrin signaling ¹	11.14	PLAT PLAU
7	Endochondral Ossification ¹	11.14	PLAT PLAU VEGFA
8	Cell adhesion_Plasmin signaling ²²	10.82	PLAT PLAU VEGFA
9	NOTCH1 regulation of human endothelial cell calcification ¹	10.62	PLAT VEGFA
10	Dissolution of Fibrin Clot ⁶⁶	9.91	PLAT PLAU SERPINB2

Sources

GO Terms for Ovarian Cyst

Cellular components related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.5	AFP MUC16 PLAT PLAU PRL SERPINB2
2	secretory granule	GO:0030141	9.33	PLAT PRL VEGFA
3	extracellular space	GO:0005615	9.17	AFP MUC16 PLAT PLAU PRL SERPINB2

Biological processes related to Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to hypoxia	GO:0001666	9.43	PLAT PLAU VEGFA
2	positive regulation of epithelial cell proliferation	GO:0050679	9.4	PRL VEGFA
3	lactation	GO:0007595	9.37	PRL VEGFA
4	ovarian follicle development	GO:0001541	9.32	FOXL2 VEGFA
5	plasminogen activation	GO:0031639	9.16	PLAT PLAU
6	smooth muscle cell migration	GO:0014909	8.96	PLAT PLAU
7	fibrinolysis	GO:0042730	8.8	PLAT PLAU SERPINB2

Sources

Sources for Ovarian Cyst

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia