MCID: OVR048
MIFTS: 32

Ovarian Cystadenoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Cystadenoma

MalaCards integrated aliases for Ovarian Cystadenoma:

Name: Ovarian Cystadenoma 12 54 15 71
Simple Cystoma of the Ovary 12
Cystoma Serosum Simplex 12
Simple Cystoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3269
NCIt 49 C4060
SNOMED-CT 67 198297004
UMLS 71 C0346169

Summaries for Ovarian Cystadenoma

Disease Ontology : 12 An ovarian benign neoplasm that has material basis in glandular epithelial tissue in which cystic accumulations of retained secretions are formed.

MalaCards based summary : Ovarian Cystadenoma, also known as simple cystoma of the ovary, is related to mucinous ovarian cystadenoma and cystadenoma. An important gene associated with Ovarian Cystadenoma is BRCA1 (BRCA1 DNA Repair Associated), and among its related pathways/superpathways is DNA Damage Induced 14-3-3Sigma Signaling. The drugs Heparin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and skin, and related phenotype is renal/urinary system.

Wikipedia : 74 Ovarian cystadenoma is a cystic benign tumor of the ovary. Two types are recognized: serous and... more...

Related Diseases for Ovarian Cystadenoma

Diseases related to Ovarian Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 mucinous ovarian cystadenoma 32.8 KRT7 GAST FH CEACAM5
2 cystadenoma 29.9 MUC16 KRT7 FH CEACAM5 BRCA1
3 tuberculous peritonitis 29.9 MUC16 CEACAM5
4 struma ovarii 29.9 MUC16 KRT7
5 ovarian serous cystadenocarcinoma 29.0 TP53 MUC16 ESS2 CEACAM5 BRCA1
6 ovarian cystadenocarcinoma 28.7 TP53 MUC16 ESS2 CEACAM5 BRCA1
7 cystadenocarcinoma 28.4 TP53 MUC16 KRT7 CEACAM5 BRCA1 AREG
8 ovarian cancer 27.3 TP53 MUC16 KRT7 CLU CLDN4 CLDN3
9 ovarian papillary cystadenoma 11.4
10 ovarian endometrioid cystadenoma 11.4
11 squamous blepharitis 10.4 SELE AREG
12 senile ectropion 10.4 MUC16 LMNA
13 basaloid lung carcinoma 10.3 TP53 BRCA1
14 cystadenofibroma 10.2 MUC16 KRT7
15 ovarian carcinosarcoma 10.2 TP53 BRCA1
16 mutagen sensitivity 10.2 TP53 BRCA1
17 bizarre leiomyoma 10.2 TP53 FH
18 ovarian brenner tumor 10.2 MUC16 KRT7
19 primary peritoneal carcinoma 10.1 TP53 MUC16 BRCA1
20 breast carcinoma in situ 10.1 TP53 CLDN4 BRCA1
21 papillary cystadenocarcinoma 10.1 MUC16 KRT7
22 endometrial serous adenocarcinoma 10.1 TP53 CLDN3 BRCA1
23 fibroma 10.1
24 ovarian cyst 10.1
25 polyploidy 10.1
26 werner syndrome 10.1 TP53 LMNA BRCA1
27 spiradenoma 10.0 TP53 KRT7
28 rectum neuroendocrine neoplasm 10.0 KRT7 GAST
29 ovarian seromucinous carcinoma 10.0 TP53 KRT7
30 apocrine adenocarcinoma 10.0 TP53 KRT7
31 intratubular embryonal carcinoma 10.0 TP53 KRT7
32 necrotizing sialometaplasia 10.0 TP53 KRT7
33 gallbladder benign neoplasm 10.0 TP53 KRT7
34 myoma 10.0 TP53 MUC16 FH
35 breast hemangioma 10.0 TP53 KRT7
36 papillary transitional carcinoma 10.0 TP53 KRT7
37 wolffian duct adenocarcinoma 10.0 TP53 KRT7
38 large cell acanthoma 10.0 TP53 KRT7
39 acanthoma 10.0 TP53 KRT7
40 glandular cystitis 10.0 TP53 KRT7
41 ectopic pregnancy 9.9
42 amenorrhea 9.9
43 zollinger-ellison syndrome 9.9
44 renal cell carcinoma, papillary, 1 9.9
45 proteasome-associated autoinflammatory syndrome 1 9.9
46 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 9.9
47 lipoid congenital adrenal hyperplasia 9.9
48 triiodothyronine receptor auxiliary protein 9.9
49 hereditary leiomyomatosis and renal cell cancer 9.9
50 renal cell carcinoma, nonpapillary 9.9

Graphical network of the top 20 diseases related to Ovarian Cystadenoma:



Diseases related to Ovarian Cystadenoma

Symptoms & Phenotypes for Ovarian Cystadenoma

MGI Mouse Phenotypes related to Ovarian Cystadenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 BRCA1 CLDN4 CLU FH KRT7 LMNA

Drugs & Therapeutics for Ovarian Cystadenoma

Drugs for Ovarian Cystadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational 9005-49-6 46507594 772
2
Nadroparin Approved, Investigational
3 calcium heparin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Studio Pilota Farmacocinetico-clinico Sulla Somministrazione di Eparina a Basso Peso Molecolare e Dosaggio Sierico di HGF Nelle Pazienti Operate Affette da Patologie Ginecologiche Completed NCT01523652

Search NIH Clinical Center for Ovarian Cystadenoma

Genetic Tests for Ovarian Cystadenoma

Anatomical Context for Ovarian Cystadenoma

MalaCards organs/tissues related to Ovarian Cystadenoma:

40
Ovary, Bone, Skin

Publications for Ovarian Cystadenoma

Articles related to Ovarian Cystadenoma:

(show top 50) (show all 117)
# Title Authors PMID Year
1
Ovarian cystadenoma as a characteristic feature of families with hereditary ovarian cancers unassociated with BRCA1 and BRCA2 mutations. 61 54
15131356 2004
2
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. 61 54
12855632 2003
3
Synthesis of a potential tetrasaccharide ligand for E-selectin. 61 54
11909595 2002
4
Sulfated blood group Lewis(a). A superior oligosaccharide ligand for human E-selectin. 61 54
7507478 1994
5
Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. 54 61
1382586 1992
6
A young woman from an Echinococcus-endemic area with progressive abdominal distension: a case report. 61
32507106 2020
7
Detection of human cytomegalovirus in patients with epithelial ovarian cancer and its impacts on survival. 61
32322296 2020
8
A Nomogram Combined Radiomic and Semantic Features as Imaging Biomarker for Classification of Ovarian Cystadenomas. 61
32547958 2020
9
A Collision between Fibroma and Serous Ovarian Cystadenoma Mimicking Carcinoma. 61
32337883 2019
10
Haemodynamic and respiratory changes following surgical resection of a giant ovarian cystadenoma. 61
31826906 2019
11
A 27-kg Giant Ovarian Mucinous Cystadenoma in a 72-Year-Old Postmenopausal Patient: A Case Report. 61
31672957 2019
12
Preoperative Optimization and Choreographed Physiological Evaluation for Resection of Giant Abdominal Neoplasm: A Case Report. 61
31021824 2019
13
Impact of Human Cytomegalovirus Infection and its Immune Response on Survival of Patients with Ovarian Cancer. 61
30172882 2018
14
Exosomal microRNAs as tumor markers in epithelial ovarian cancer. 61
30107086 2018
15
Extraparenchymal ovarian and testicular Leydig cells: ectopic/heterotopic or orthotopic? 61
29971558 2018
16
Ovarian serous cystadenoma with ectopic adrenal tissue in a 65-year-old patient: A case report. 61
28285211 2017
17
Ovarian Adenomatoid Tumor Coexisting with Mature Cystic Teratoma: A Rare Case Report. 61
29085685 2017
18
An unexpected death due to massive ascites and a giant mucinous ovarian cystadenoma. 61
27890095 2016
19
Ruptured benign serous ovarian cystadenoma mimicking ovarian malignancy with peritoneal carcinomatosis. 61
27421673 2016
20
Ovarian Cystadenoma in a Trafficked Patient. 61
27244785 2016
21
Redundant plantar skin folds. 61
28002528 2016
22
Endometrial stromal nodule - a case report. 61
25725687 2015
23
Presacral epidermoid cyst in an elderly female, mistaken for ovarian cystadenoma. 61
25404834 2014
24
Pseudomixoma peritonei, a rare entity difficult to diagnose and treat - case report. 61
25560512 2014
25
The unique case of foot drop secondary to a large ovarian cyst. 61
24447226 2014
26
Bilateral ovarian cystadenoma in a geriatric African elephant (Loxodonta africana). 61
25000708 2014
27
Perioperative management for the removal of a massive ovarian cystadenoma. 61
25612086 2013
28
Massive Hematometra due to Congenital Cervicovaginal Agenesis in an Adolescent Girl Treated by Hysterectomy: A Case Report. 61
23533866 2013
29
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. 61
21792894 2012
30
AT-rich sequence binding protein 1: Contribution to tumor progression and metastasis of human ovarian carcinoma. 61
22741008 2012
31
Abnormal ¹³¹I uptake in a benign serous ovarian cystadenoma mimicking bladder physiological uptake. 61
22310273 2012
32
Reduced CMTM5 expression correlates with carcinogenesis in human epithelial ovarian cancer. 61
21841490 2011
33
FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5. 61
20943720 2011
34
Cutaneous and uterine leiomyomatosis and ovarian cystadenoma associated with deficiency of fumarate hydratase. 61
24396716 2011
35
A woman with salt-wasting congenital adrenal hyperplasia presenting with a mucinous ovarian cystadenoma during pregnancy. 61
21921381 2011
36
Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. 61
20819672 2010
37
Expression of peptidylarginine deiminase type 4 in ovarian tumors. 61
20827398 2010
38
[Various acute phase reactants in different types of proliferative diseases of the uterine appendages]. 61
20000108 2009
39
[Ovarian cystadenoma and ectopic pregnancy. A case report]. 61
19902630 2009
40
The expression and significance of Dickkopf-1 in epithelial ovarian carcinoma. 61
19787627 2009
41
[Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance]. 61
19403395 2009
42
Serous and seromucinous infantile ovarian cystadenomas--a study of 42 cases. 61
18996636 2009
43
Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma. 61
18574502 2008
44
Peutz-Jegher's syndrome with ovarian serous cystadenoma: an unusual association. 61
18306547 2007
45
Increased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas. 61
17519898 2007
46
[Giant ovarian cystadenoma in an adolescent]. 61
17266865 2007
47
Abnormal iodine-131 uptake in a benign mucinous ovarian cystadenoma mimicking struma ovarii. 61
17179812 2007
48
Rapidly growing bilateral ovarian cystadenoma in a 6-year-old girl: case report and literature review. 61
16472727 2006
49
Potential markers that complement expression of CA125 in epithelial ovarian cancer. 54
16061277 2005
50
[Giant benign mucinous cystadenoma of both ovaries in early puerperium: case report and review of literature]. 61
15918273 2005

Variations for Ovarian Cystadenoma

Expression for Ovarian Cystadenoma

Search GEO for disease gene expression data for Ovarian Cystadenoma.

Pathways for Ovarian Cystadenoma

Pathways related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 TP53 BRCA1

GO Terms for Ovarian Cystadenoma

Cellular components related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apicolateral plasma membrane GO:0016327 8.96 CLDN4 CLDN3
2 tight junction GO:0070160 8.62 CLDN4 CLDN3

Biological processes related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.65 SELE MUC16 CLDN4 CLDN3 CEACAM5
2 positive regulation of gene expression GO:0010628 9.55 TP53 LMNA CLU CLDN3 BRCA1
3 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.43 LMNA CLU
4 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 9.4 CLDN4 CLDN3
5 epithelial cell morphogenesis GO:0003382 9.37 VSIG1 CLDN3
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 TP53 BRCA1
7 positive regulation of metallopeptidase activity GO:1905050 8.96 CLDN4 CLDN3
8 positive regulation of cell aging GO:0090343 8.62 TP53 LMNA

Molecular functions related to Ovarian Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 TP53 SELE MUC16 LMNA KRT7 GAST

Sources for Ovarian Cystadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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