MCID: OVR017
MIFTS: 35

Ovarian Cystic Teratoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Cystic Teratoma

MalaCards integrated aliases for Ovarian Cystic Teratoma:

Name: Ovarian Cystic Teratoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5118
NCIt 50 C7283
UMLS 73 C1335155

Summaries for Ovarian Cystic Teratoma

Disease Ontology : 12 A cystic teratoma that is located in the ovary.

MalaCards based summary : Ovarian Cystic Teratoma is related to cystic teratoma and malignant syringoma. An important gene associated with Ovarian Cystic Teratoma is NECTIN2 (Nectin Cell Adhesion Molecule 2), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). Affiliated tissues include ovary, b cells and pituitary, and related phenotypes are immune system and neoplasm

Related Diseases for Ovarian Cystic Teratoma

Diseases related to Ovarian Cystic Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 cystic teratoma 31.6 KRT20 KRT7 NKX2-1
2 malignant syringoma 30.3 KRT7 KRT20
3 teratoma 10.9
4 melanoma 10.5
5 athyreosis 10.3 TG NKX2-1
6 cystic basal cell carcinoma 10.3 KRT7 KRT20
7 appendix adenocarcinoma 10.3 KRT7 KRT20
8 transverse colon cancer 10.3 KRT7 KRT20
9 seminal vesicle adenocarcinoma 10.3 KRT7 KRT20
10 krukenberg carcinoma 10.3 KRT7 KRT20
11 eyelid carcinoma 10.3 KRT7 KRT20
12 papillary transitional carcinoma 10.3 KRT7 KRT20
13 glandular cystitis 10.3 KRT7 KRT20
14 linitis plastica 10.3 KRT7 KRT20
15 large intestine adenocarcinoma 10.3 KRT7 KRT20
16 struma ovarii 10.3 TG NKX2-1
17 solid adenocarcinoma with mucin production 10.3 NKX2-1 KRT7
18 intratubular embryonal carcinoma 10.3 KRT7 KRT20
19 adenoid squamous cell carcinoma 10.3 KRT7 KRT20
20 bile duct adenoma 10.3 KRT7 KRT20
21 malignant struma ovarii 10.3 NKX2-1 TG
22 bile duct cystadenocarcinoma 10.2 KRT7 KRT20
23 papillary adenoma 10.2 NKX2-1 KRT7
24 vulval paget's disease 10.2 KRT7 KRT20
25 meibomian cyst 10.2 KRT7 KRT20
26 gastric diffuse adenocarcinoma 10.2 KRT7 KRT20
27 appendix disease 10.2 KRT7 KRT20
28 thymus adenocarcinoma 10.2 KRT7 KRT20
29 rete testis adenocarcinoma 10.2 KRT20 NKX2-1
30 ovarian mucinous adenocarcinoma 10.2 KRT7 KRT20
31 jejunal adenocarcinoma 10.2 KRT7 KRT20
32 basilar artery insufficiency 10.2 PVR CALCA
33 bladder adenocarcinoma 10.2 KRT20 KRT7
34 mucoepidermoid thyroid carcinoma 10.2 TG CALCA
35 hypothyroidism, congenital, nongoitrous, 2 10.2 NKX2-1 TG
36 bladder lymphoma 10.2 KRT7 KRT20
37 suppurative thyroiditis 10.2 TG CALCA
38 chronic cystitis 10.2 KRT20 KRT7
39 thyroid sarcoma 10.2 TG CALCA
40 vulva adenocarcinoma 10.2 KRT20 KRT7
41 intestinal perforation 10.2 KRT7 NKX2-1
42 atypical follicular adenoma 10.2 TG CALCA
43 medulloepithelioma 10.2 KRT20 KRT7
44 glycogen-rich clear cell breast carcinoma 10.2 KRT20 KRT7
45 cutaneous adenocystic carcinoma 10.2 KRT7 B2M
46 adenoid basal cell carcinoma 10.2 KRT7 B2M
47 pulmonary sclerosing hemangioma 10.2 KRT7 NKX2-1
48 acute thyroiditis 10.2 TG CALCA
49 rectum adenocarcinoma 10.2 KRT20 KRT7
50 colloid adenoma 10.2 KRT20 NKX2-1 TG

Graphical network of the top 20 diseases related to Ovarian Cystic Teratoma:



Diseases related to Ovarian Cystic Teratoma

Symptoms & Phenotypes for Ovarian Cystic Teratoma

MGI Mouse Phenotypes related to Ovarian Cystic Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.61 ADAM17 B2M CD226 CD276 GAST IRF4
2 neoplasm MP:0002006 9.1 B2M CD226 GAST IRF4 NKX2-1 PRL

Drugs & Therapeutics for Ovarian Cystic Teratoma

Search Clinical Trials , NIH Clinical Center for Ovarian Cystic Teratoma

Genetic Tests for Ovarian Cystic Teratoma

Anatomical Context for Ovarian Cystic Teratoma

MalaCards organs/tissues related to Ovarian Cystic Teratoma:

41
Ovary, B Cells, Pituitary, Thyroid, Thymus, Lung, Appendix

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Cystic Teratoma:

19
The Ovary

Publications for Ovarian Cystic Teratoma

Articles related to Ovarian Cystic Teratoma:

(show top 50) (show all 69)
# Title Authors Year
1
Mature ovarian cystic teratoma with disseminated nodular lesions in the pleural and peritoneal cavities: A case report. ( 30042811 )
2018
2
A Rare Malignant Transformation of an Ovarian Cystic Teratoma: A Case Report. ( 30112238 )
2018
3
Superinfection of mature ovarian cystic teratoma in a child: An unusual presentation. ( 30197369 )
2018
4
Immune checkpoint inhibitors of CTLA4 and PD-1 for malignant melanoma arising in ovarian cystic teratoma: A case report. ( 30412106 )
2018
5
Live birth following laparoscopic fertility-sparing surgery for papillary thyroid carcinoma arising from mature ovarian cystic teratoma: A case report. ( 30546889 )
2018
6
Mature ovarian cystic teratoma containing well-differentiated cerebellar tissue. ( 29949297 )
2017
7
Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes. ( 28643027 )
2017
8
Primary malignant melanoma arising in an ovarian cystic teratoma. ( 29016386 )
2017
9
Diffuse large B-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. ( 26980033 )
2016
10
Synchronous Primary Endometrial Carcinoma and Metastatic Malignant Melanoma in an Ovarian Cystic Teratoma. ( 24715550 )
2014
11
Diffuse large B-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. ( 25439346 )
2014
12
Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease. ( 25210635 )
2014
13
Primitive neuroectodermal tumor in an ovarian cystic teratoma: natural killer and neuroblastoma cell analysis. ( 24575020 )
2014
14
Ectopic prolactin-producing pituitary adenoma in a benign ovarian cystic teratoma. ( 24584638 )
2014
15
A floating ball: a pathognomonic sign of ovarian cystic teratoma. ( 23764514 )
2013
16
Mature ovarian cystic teratoma (dermoid cyst). ( 22902841 )
2012
17
Conservative surgery in the management of a benign ovarian cystic teratoma presenting as a rectal mass: a case report. ( 21943447 )
2011
18
Intestinal obstruction due to bilateral ovarian cystic teratoma in a pregnant woman: report of a case. ( 21987947 )
2011
19
An unusual growth of ovarian cystic teratoma with multiple floating balls during pregnancy: a case report. ( 20544870 )
2010
20
Ovarian cystic teratoma torsion in pregnancy. ( 20810465 )
2010
21
Spontaneous rupture of benign ovarian cystic teratoma in a premenarcheal girl. ( 19576813 )
2009
22
Primary malignant melanoma arising in an ovarian cystic teratoma. ( 19317266 )
2009
23
A case of sebaceous carcinoma arising within a benign ovarian cystic teratoma. ( 19521124 )
2009
24
Ovarian cystic teratoma with a pathognomonic appearance of multiple floating balls: a case report and investigation of common characteristics of the cases in the literature. ( 18304549 )
2008
25
Ruptured ovarian cystic teratoma in pregnancy with diffuse peritoneal reaction mimicking advanced ovarian malignancy: a case report. ( 18549490 )
2008
26
Irregular dental structures in a benign ovarian cystic teratoma (dermoid cyst): case report. ( 18581775 )
2008
27
Giant mature ovarian cystic teratoma including more than 300 teeth. ( 18280952 )
2008
28
Ruptured ovarian cystic teratoma secondary to blunt abdominal trauma: a very unusual case. ( 17308491 )
2007
29
Pathogenesis of balls in mature ovarian cystic teratoma. Report of 3 cases and review of literature. ( 16990711 )
2006
30
Floating ball appearance in ovarian cystic teratoma. ( 16972218 )
2006
31
Are they spherules of ovarian cystic teratoma or daughter cysts of echinococcosis? ( 17146747 )
2006
32
Unusual fast-growing ovarian cystic teratoma during pregnancy presenting with intracystic fat "floating balls" appearance. ( 17067585 )
2006
33
Ovarian cystic teratoma with primary epithelial cell melanoma. ( 15755005 )
2005
34
Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review. ( 16343199 )
2005
35
Monolateral mature ovarian cystic teratoma. ( 15746800 )
2005
36
MR and ultrasound imaging of floating globules in mature ovarian cystic teratoma. ( 15205564 )
2004
37
Mature ovarian cystic teratoma with a highly differentiated homunculus: a case report. ( 14745894 )
2004
38
Adenocarcinoma arising from respiratory ciliated epithelium in mature ovarian cystic teratoma. ( 12439559 )
2002
39
Ovarian cystic teratoma: determined phenotypic response of keratocytes and uncommon intracystic floating balls appearance on sonography and computed tomography. ( 12054308 )
2002
40
Small bowel perforation with minor trauma: a rare complication of an ovarian cystic teratoma. ( 12435956 )
2002
41
Primary malignant melanoma in ovarian cystic teratoma. ( 11531299 )
2001
42
Unusual "floating balls" appearance of an ovarian cystic teratoma: sonographic and CT findings. ( 11180183 )
2001
43
Amelanotic malignant melanoma arising in an ovarian cystic teratoma: a case report. ( 11575655 )
2001
44
Analysis of 20 mature ovarian cystic teratoma cases in postmenopausal women. ( 11780192 )
2001
45
Radiology case of the month. Abdominal mass. Bilateral ovarian cystic teratoma. ( 10851824 )
2000
46
Thymus tissue in ovarian cystic teratoma: possible clues to its histogenesis. ( 11186178 )
2000
47
Conservative management of ovarian cystic teratoma during pregnancy and labor. ( 10739498 )
2000
48
Primary malignant melanoma arising in an ovarian cystic teratoma. ( 9743462 )
1998
49
Mature ovarian cystic teratoma with combined squamous cell carcinoma and malignant melanoma. ( 9808441 )
1998
50
Malignant melanoma arising in mature ovarian cystic teratoma (dermoid cyst). Report of two cases and literature analysis. ( 8886884 )
1996

Variations for Ovarian Cystic Teratoma

Expression for Ovarian Cystic Teratoma

Search GEO for disease gene expression data for Ovarian Cystic Teratoma.

Pathways for Ovarian Cystic Teratoma

Pathways related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.07 B2M CD276 IRF4 MLANA PVR
2 11.72 CD226 CD276 NECTIN2 PVR
3 11.15 B2M CD226 NECTIN2 PVR SLAMF6
4 11.02 CD226 CD276 NECTIN2 PVR
5 10.72 NECTIN2 PVR

GO Terms for Ovarian Cystic Teratoma

Cellular components related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.26 ADAM17 B2M NECTIN2 PVR
2 cell surface GO:0009986 9.02 ADAM17 B2M CD226 NECTIN2 PVR

Biological processes related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.83 CALCA GAST IFNA2 PRL TG
2 thyroid gland development GO:0030878 9.49 NKX2-1 TG
3 positive regulation of T cell receptor signaling pathway GO:0050862 9.48 CD226 NECTIN2
4 susceptibility to natural killer cell mediated cytotoxicity GO:0042271 9.46 NECTIN2 PVR
5 regulation of immune response GO:0050776 9.43 B2M CD226 CD276 NECTIN2 PVR SLAMF6
6 T-helper 17 cell lineage commitment GO:0072540 9.4 IRF4 SLAMF6
7 positive regulation of mast cell activation GO:0033005 9.37 CD226 NECTIN2
8 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 9.33 CD226 NECTIN2 PVR
9 positive regulation of immunoglobulin mediated immune response GO:0002891 9.32 CD226 NECTIN2
10 susceptibility to T cell mediated cytotoxicity GO:0060370 9.26 NECTIN2 PVR
11 positive regulation of natural killer cell mediated cytotoxicity GO:0045954 8.92 CD226 NECTIN2 PVR SLAMF6

Molecular functions related to Ovarian Cystic Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 ADAM17 B2M CALCA CD226 CD276 GAST
2 cell adhesion molecule binding GO:0050839 9.33 CD226 NECTIN2 PVR
3 hormone activity GO:0005179 8.92 CALCA GAST PRL TG

Sources for Ovarian Cystic Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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