MCID: OVR050
MIFTS: 41

Ovarian Embryonal Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Ovarian Embryonal Carcinoma

MalaCards integrated aliases for Ovarian Embryonal Carcinoma:

Name: Ovarian Embryonal Carcinoma 12 15 17 74
Embryonal Carcinoma of the Ovary 12
Embryonal Carcinoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5681
NCIt 51 C8108
UMLS 74 C0346183

Summaries for Ovarian Embryonal Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the ovary.

MalaCards based summary : Ovarian Embryonal Carcinoma, also known as embryonal carcinoma of the ovary, is related to endodermal sinus tumor and embryonal carcinoma, and has symptoms including abdominal pain An important gene associated with Ovarian Embryonal Carcinoma is ICK (Intestinal Cell Kinase), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Human Embryonic Stem Cell Pluripotency. The drugs Bleomycin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovarian Embryonal Carcinoma

Diseases related to Ovarian Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 30.6 AFP GPC3
2 embryonal carcinoma 29.5 AFP POU5F1 SOX2 TNFRSF8
3 teratoma 29.2 AFP KRT7 POU5F1 SOX2
4 childhood ovarian embryonal carcinoma 12.5
5 testicular malignant germ cell cancer 10.2 AFP GPC3
6 hepatic adenomas, familial 10.2 AFP GPC3
7 brain germinoma 10.2 AFP POU5F1
8 extragonadal germ cell cancer 10.2 AFP POU5F1
9 embryonal testis carcinoma 10.2 AFP POU5F1
10 malignant teratoma 10.2 AFP POU5F1
11 mature teratoma 10.2 AFP POU5F1
12 ovarian solid teratoma 10.2 AFP TNFRSF8
13 sternum cancer 10.2 AFP TNFRSF8
14 pineoblastoma 10.2 AFP POU5F1
15 mixed germ cell cancer 10.2 AFP POU5F1
16 hydrolethalus syndrome 1 10.1 AFP ICK
17 intrahepatic bile duct adenoma 10.1 AFP KRT7
18 renal pelvis adenocarcinoma 10.1 AFP KRT7
19 ovarian germ cell cancer 10.1 AFP KRT7
20 bile duct cystadenocarcinoma 10.1 AFP KRT7
21 choriocarcinoma of the testis 10.1 AFP KRT7
22 adenomatoid tumor 10.1 AFP KRT7
23 non-functioning pancreatic endocrine tumor 10.1 POU5F1 SOX2
24 situs inversus 10.1
25 sertoli-leydig cell tumor 10.1 AFP KRT7
26 cystadenofibroma 10.1 AFP KRT7
27 acinar cell carcinoma 10.0 AFP KRT7
28 sex cord-gonadal stromal tumor 10.0 AFP KRT7
29 ampulla of vater adenocarcinoma 10.0 KRT7 SOX2
30 vulvitis 10.0 KRT7 TNFRSF8
31 ovarian clear cell carcinoma 10.0 GPC3 KRT7
32 dysgerminoma 10.0 AFP KRT7
33 testicular yolk sac tumor 10.0 AFP GPC3 POU5F1
34 thymus lipoma 10.0 KRT7 TNFRSF8
35 atypical choroid plexus papilloma 10.0 KRT7 SOX2
36 bile duct disease 10.0 AFP KRT7
37 immune system organ benign neoplasm 10.0 KRT7 TNFRSF8
38 seminoma 9.9 AFP POU5F1 TNFRSF8
39 testicular germ cell tumor 9.9 AFP GPC3
40 biliary tract disease 9.9 AFP KRT7
41 central nervous system germ cell tumor 9.9 AFP POU5F1 SOX2
42 dextrocardia with situs inversus 9.9
43 testicular infarct 9.9 AFP POU5F1 TNFRSF8
44 ocular cancer 9.9 POU5F1 SOX2
45 seminal vesicle tumor 9.9 AFP GPC3 KRT7
46 ovarian endodermal sinus tumor 9.9 AFP GPC3 KRT7
47 ovarian primitive germ cell tumor 9.9 AFP GPC3 KRT7
48 bile duct adenocarcinoma 9.9 AFP GPC3 KRT7
49 nemaline myopathy 2 9.9 NANOG POU5F1
50 hepatoblastoma 9.9 AFP GPC3 KRT7

Graphical network of the top 20 diseases related to Ovarian Embryonal Carcinoma:



Diseases related to Ovarian Embryonal Carcinoma

Symptoms & Phenotypes for Ovarian Embryonal Carcinoma

UMLS symptoms related to Ovarian Embryonal Carcinoma:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.5 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.5 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.5 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.5 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.5 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.5 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.5 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.5 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.5 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.5 AFP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 KRT7 POU5F1

MGI Mouse Phenotypes related to Ovarian Embryonal Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.1 GPC3 ICK KRT7 NANOG POU5F1 SOX2

Drugs & Therapeutics for Ovarian Embryonal Carcinoma

Drugs for Ovarian Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 441203 84093 2767
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Captopril Approved Phase 3 62571-86-2 44093
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
6
Palivizumab Approved, Investigational Phase 3 188039-54-5
7
Ribavirin Approved Phase 3 36791-04-5 37542
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
10
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
11
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
12
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718 468682
13
Carboplatin Approved Phase 3,Phase 2 41575-94-4 38904 10339178 498142
14 Anti-Bacterial Agents Phase 3
15 Etoposide phosphate Phase 3
16 Topoisomerase Inhibitors Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
19 Antihypertensive Agents Phase 3
20 Antirheumatic Agents Phase 3
21 Alkylating Agents Phase 3,Phase 2
22 Immunologic Factors Phase 3,Phase 2,Phase 1
23 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
24 Angiotensin-Converting Enzyme Inhibitors Phase 3
25
protease inhibitors Phase 3
26 Antineoplastic Agents, Alkylating Phase 3,Phase 2
27 HIV Protease Inhibitors Phase 3
28 Antiviral Agents Phase 3,Phase 2
29 Immunoglobulins Phase 3,Phase 1
30 Antibodies, Monoclonal Phase 3,Phase 1
31 Antimetabolites Phase 3
32 Anti-Infective Agents Phase 3,Phase 2
33 Antibodies Phase 3,Phase 1
34 Hormone Antagonists Phase 3,Phase 1,Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
36 Antifungal Agents Phase 3
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
38 Hormones Phase 3,Phase 1,Phase 2
39 Steroid Synthesis Inhibitors Phase 3
40
Hydroxyitraconazole Phase 3
41 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 3
43 Cytochrome P-450 CYP3A Inhibitors Phase 3
44 Liposomal amphotericin B Phase 3
45 Antiprotozoal Agents Phase 3
46 Antiparasitic Agents Phase 3
47 Antimitotic Agents Phase 3,Phase 2,Phase 1
48 Dermatologic Agents Phase 3
49 Podophyllotoxin Phase 3 518-28-5
50 Keratolytic Agents Phase 3

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
17 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
20 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
21 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
22 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Ovarian Embryonal Carcinoma

Genetic Tests for Ovarian Embryonal Carcinoma

Anatomical Context for Ovarian Embryonal Carcinoma

MalaCards organs/tissues related to Ovarian Embryonal Carcinoma:

42
Ovary, Bone, Bone Marrow, Brain, Colon, Breast, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Embryonal Carcinoma:

20
The Ovary

Publications for Ovarian Embryonal Carcinoma

Articles related to Ovarian Embryonal Carcinoma:

# Title Authors Year
1
Ovarian Embryonal Carcinoma in a Dog. ( 29169625 )
2017
2
Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma. ( 20096442 )
2010
3
Liver metastasis from embryonal carcinoma of the ovary with complete situs inversus. First reported case and review of literature. ( 6386265 )
1984
4
A patient with situs inversus totalis and embryonal carcinoma of the ovary. ( 6500379 )
1984
5
Alpha-fetoprotein and human chorionic gonadotropin in embryonal carcinoma of the ovary. An 8-year survival case. ( 6193860 )
1983
6
Embryonal carcinoma of the ovary occurring with pregnancy. ( 881372 )
1977
7
Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary. ( 5318716 )
1965
8
Embryonal carcinoma of the ovary. ( 14479144 )
1962

Variations for Ovarian Embryonal Carcinoma

Expression for Ovarian Embryonal Carcinoma

Search GEO for disease gene expression data for Ovarian Embryonal Carcinoma.

Pathways for Ovarian Embryonal Carcinoma

GO Terms for Ovarian Embryonal Carcinoma

Biological processes related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.62 ICK NANOG POU5F1 SOX2
2 response to wounding GO:0009611 9.37 POU5F1 SOX2
3 somatic stem cell population maintenance GO:0035019 9.33 NANOG POU5F1 SOX2
4 negative regulation of epithelial cell proliferation GO:0050680 9.26 GPC3 SOX2
5 regulation of gene expression GO:0010468 9.26 ICK NANOG POU5F1 SOX2
6 endodermal cell fate specification GO:0001714 8.8 NANOG POU5F1 SOX2

Molecular functions related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 8.96 POU5F1 SOX2
2 miRNA binding GO:0035198 8.62 POU5F1 SOX2

Sources for Ovarian Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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