MCID: OVR050
MIFTS: 42

Ovarian Embryonal Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Ovarian Embryonal Carcinoma

MalaCards integrated aliases for Ovarian Embryonal Carcinoma:

Name: Ovarian Embryonal Carcinoma 12 15 73
Embryonal Carcinoma of the Ovary 12
Embryonal Carcinoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5681
NCIt 50 C8108
UMLS 73 C0346183

Summaries for Ovarian Embryonal Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the ovary.

MalaCards based summary : Ovarian Embryonal Carcinoma, also known as embryonal carcinoma of the ovary, is related to endodermal sinus tumor and teratoma, and has symptoms including abdominal pain An important gene associated with Ovarian Embryonal Carcinoma is ICK (Intestinal Cell Kinase), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Wnt Signaling Pathway and Pluripotency. The drugs Bleomycin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Ovarian Embryonal Carcinoma

Diseases related to Ovarian Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 29.9 AFP GPC3
2 teratoma 29.6 AFP POU5F1 SOX2
3 embryonal carcinoma 29.6 AFP POU5F1 SOX2 TNFRSF8
4 childhood ovarian embryonal carcinoma 12.5
5 cystic lymphangioma 10.1 AFP NODAL
6 testicular malignant germ cell cancer 10.1 AFP GPC3
7 patau syndrome 10.1 AFP NODAL
8 hepatic adenomas, familial 10.1 AFP GPC3
9 seminal vesicle tumor 10.1 AFP GPC3
10 ovarian solid teratoma 10.1 AFP TNFRSF8
11 brain germinoma 10.1 AFP POU5F1
12 sternum cancer 10.1 AFP TNFRSF8
13 extragonadal germ cell cancer 10.1 AFP POU5F1
14 ovarian endodermal sinus tumor 10.1 AFP GPC3
15 embryonal testis carcinoma 10.1 AFP POU5F1
16 malignant teratoma 10.1 AFP POU5F1
17 mature teratoma 10.1 AFP POU5F1
18 hydrolethalus syndrome 1 10.1 AFP ICK
19 situs inversus 10.1
20 ovarian primitive germ cell tumor 10.1 AFP GPC3
21 pineoblastoma 10.1 AFP POU5F1
22 mixed germ cell cancer 10.1 AFP POU5F1
23 bile duct adenocarcinoma 10.1 AFP GPC3
24 mixed cell type cancer 10.0 AFP POU5F1
25 malignant leydig cell tumor 10.0 POU5F1 TNFRSF8
26 physical disorder 10.0 AFP NODAL
27 non-functioning pancreatic endocrine tumor 10.0 POU5F1 SOX2
28 testicular germ cell tumor 9.9 AFP GPC3
29 testicular yolk sac tumor 9.9 AFP GPC3 POU5F1
30 dextrocardia with situs inversus 9.9
31 seminoma 9.9 AFP POU5F1 TNFRSF8
32 intratubular embryonal carcinoma 9.9 AFP POU5F1 TNFRSF8
33 testicular infarct 9.9 AFP POU5F1 TNFRSF8
34 ocular cancer 9.9 POU5F1 SOX2
35 nemaline myopathy 2 9.9 NANOG POU5F1
36 central nervous system germ cell tumor 9.9 AFP POU5F1 SOX2
37 hepatoblastoma 9.9 AFP GPC3
38 teratocarcinoma 9.8 NANOG POU5F1
39 embryoma 9.8 AFP GPC3 POU5F1 TNFRSF8
40 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 9.7 NANOG POU5F1 SOX2
41 venous hemangioma 9.7 NANOG POU5F1 SOX2
42 phosphoglycerate dehydrogenase deficiency 9.7 NANOG POU5F1 SOX2
43 brain cancer 9.6 NANOG POU5F1 SOX2
44 germ cell and embryonal cancer 9.6 AFP NANOG POU5F1 SOX2
45 germ cell cancer 9.6 AFP NANOG POU5F1 SOX2
46 extragonadal seminoma 9.4 AFP NANOG POU5F1 SOX2 TNFRSF8

Graphical network of the top 20 diseases related to Ovarian Embryonal Carcinoma:



Diseases related to Ovarian Embryonal Carcinoma

Symptoms & Phenotypes for Ovarian Embryonal Carcinoma

UMLS symptoms related to Ovarian Embryonal Carcinoma:


abdominal pain

MGI Mouse Phenotypes related to Ovarian Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 GPC3 ICK NANOG NODAL POU5F1 SOX2
2 digestive/alimentary MP:0005381 9.65 GPC3 ICK NODAL POU5F1 SOX2
3 craniofacial MP:0005382 9.62 GPC3 ICK NODAL SOX2
4 embryo MP:0005380 9.55 GPC3 NANOG NODAL POU5F1 SOX2
5 mortality/aging MP:0010768 9.5 AFP GPC3 ICK NANOG NODAL POU5F1
6 reproductive system MP:0005389 9.02 AFP GPC3 NODAL POU5F1 SOX2

Drugs & Therapeutics for Ovarian Embryonal Carcinoma

Drugs for Ovarian Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
5
Captopril Approved Phase 3 62571-86-2 44093
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Palivizumab Approved, Investigational Phase 3 188039-54-5
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
12
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
13
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
14 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
15 Etoposide phosphate Phase 3
16 Anti-Bacterial Agents Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Topoisomerase Inhibitors Phase 3
19 Antihypertensive Agents Phase 3
20 Antineoplastic Agents, Alkylating Phase 3,Phase 2
21 Alkylating Agents Phase 3,Phase 2
22 Immunologic Factors Phase 3,Phase 2,Phase 1
23
protease inhibitors Phase 3
24 Antirheumatic Agents Phase 3
25 HIV Protease Inhibitors Phase 3
26 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
27 Angiotensin-Converting Enzyme Inhibitors Phase 3
28 Immunoglobulins Phase 3,Phase 1
29 Antimetabolites Phase 3
30 Antibodies Phase 3,Phase 1
31 Anti-Infective Agents Phase 3,Phase 2
32 Antibodies, Monoclonal Phase 3,Phase 1
33 Antiviral Agents Phase 3,Phase 2
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
35 Cytochrome P-450 CYP3A Inhibitors Phase 3
36 Steroid Synthesis Inhibitors Phase 3
37 Cytochrome P-450 Enzyme Inhibitors Phase 3
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
39
Hydroxyitraconazole Phase 3
40 Hormones Phase 3,Phase 1,Phase 2
41 Antifungal Agents Phase 3
42 Hormone Antagonists Phase 3,Phase 1,Phase 2
43 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
44 Liposomal amphotericin B Phase 3
45 Antiparasitic Agents Phase 3
46 Antiprotozoal Agents Phase 3
47 Echinocandins Phase 3
48 Antimitotic Agents Phase 3,Phase 2,Phase 1
49 Keratolytic Agents Phase 3
50 Podophyllotoxin Phase 3 518-28-5

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
17 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
20 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
21 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
22 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Ovarian Embryonal Carcinoma

Genetic Tests for Ovarian Embryonal Carcinoma

Anatomical Context for Ovarian Embryonal Carcinoma

MalaCards organs/tissues related to Ovarian Embryonal Carcinoma:

41
Ovary, Bone, Bone Marrow, Testis, Brain, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Embryonal Carcinoma:

19
The Ovary

Publications for Ovarian Embryonal Carcinoma

Articles related to Ovarian Embryonal Carcinoma:

# Title Authors Year
1
Ovarian Embryonal Carcinoma in a Dog. ( 29169625 )
2017
2
Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma. ( 20096442 )
2010
3
Liver metastasis from embryonal carcinoma of the ovary with complete situs inversus. First reported case and review of literature. ( 6386265 )
1984
4
A patient with situs inversus totalis and embryonal carcinoma of the ovary. ( 6500379 )
1984
5
Alpha-fetoprotein and human chorionic gonadotropin in embryonal carcinoma of the ovary. An 8-year survival case. ( 6193860 )
1983
6
Embryonal carcinoma of the ovary occurring with pregnancy. ( 881372 )
1977
7
Embryonal carcinoma of the ovary: a clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. ( 63319 )
1976
8
Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary. ( 5318716 )
1965
9
Embryonal carcinoma of the ovary. ( 14479144 )
1962

Variations for Ovarian Embryonal Carcinoma

Expression for Ovarian Embryonal Carcinoma

Search GEO for disease gene expression data for Ovarian Embryonal Carcinoma.

Pathways for Ovarian Embryonal Carcinoma

Pathways related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.24 NANOG NODAL POU5F1 SOX2
2
Show member pathways
12.21 NANOG POU5F1 SOX2
3
Show member pathways
12.13 NANOG POU5F1 SOX2
4 11.93 AFP NANOG POU5F1 SOX2
5 11.88 NANOG POU5F1 SOX2
6 11.77 NANOG NODAL POU5F1 SOX2
7 11.39 NANOG POU5F1 SOX2
8 11.28 NANOG POU5F1 SOX2
9
Show member pathways
11.27 NANOG POU5F1 SOX2
10 11.15 AFP NANOG NODAL POU5F1 SOX2
11 10.98 NANOG NODAL POU5F1 SOX2
12 10.66 NANOG POU5F1 SOX2
13
Show member pathways
10.33 NANOG POU5F1 SOX2

GO Terms for Ovarian Embryonal Carcinoma

Biological processes related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.83 NANOG NODAL POU5F1 SOX2
2 multicellular organism development GO:0007275 9.77 ICK NANOG NODAL POU5F1 SOX2
3 response to wounding GO:0009611 9.54 POU5F1 SOX2
4 cell fate commitment GO:0045165 9.51 NODAL SOX2
5 negative regulation of epithelial cell proliferation GO:0050680 9.49 GPC3 SOX2
6 SMAD protein signal transduction GO:0060395 9.48 AFP NODAL
7 stem cell population maintenance GO:0019827 9.46 NANOG NODAL
8 regulation of signal transduction GO:0009966 9.43 GPC3 NODAL
9 anterior/posterior axis specification GO:0009948 9.4 GPC3 NODAL
10 somatic stem cell population maintenance GO:0035019 9.33 NANOG POU5F1 SOX2
11 positive regulation of cell-cell adhesion GO:0022409 9.32 NODAL SOX2
12 cell migration involved in gastrulation GO:0042074 9.26 GPC3 NODAL
13 regulation of gene expression GO:0010468 9.26 ICK NANOG POU5F1 SOX2
14 endodermal cell fate specification GO:0001714 8.8 NANOG POU5F1 SOX2

Molecular functions related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 8.96 POU5F1 SOX2
2 miRNA binding GO:0035198 8.62 POU5F1 SOX2

Sources for Ovarian Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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