MCID: OVR050
MIFTS: 40

Ovarian Embryonal Carcinoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Ovarian Embryonal Carcinoma

MalaCards integrated aliases for Ovarian Embryonal Carcinoma:

Name: Ovarian Embryonal Carcinoma 12 15 73
Embryonal Carcinoma of the Ovary 12
Embryonal Carcinoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5681
NCIt 50 C8108
SNOMED-CT 68 254872007
UMLS 73 C0346183

Summaries for Ovarian Embryonal Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the ovary.

MalaCards based summary : Ovarian Embryonal Carcinoma, also known as embryonal carcinoma of the ovary, is related to teratoma and embryonal carcinoma, and has symptoms including abdominal pain An important gene associated with Ovarian Embryonal Carcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Wnt Signaling Pathway and Pluripotency. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include the ovary, ovary and bone marrow, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Ovarian Embryonal Carcinoma

Diseases related to Ovarian Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 teratoma 29.1 AFP POU5F1 SOX2
2 embryonal carcinoma 28.4 AFP POU5F1 SOX2 TNFRSF8
3 childhood ovarian embryonal carcinoma 12.4
4 cystic lymphangioma 10.4 AFP NODAL
5 testicular malignant germ cell cancer 10.4 AFP GPC3
6 patau syndrome 10.4 AFP NODAL
7 ovarian solid teratoma 10.4 AFP TNFRSF8
8 hepatic adenomas, familial 10.3 AFP GPC3
9 brain germinoma 10.3 AFP POU5F1
10 sternum cancer 10.3 AFP TNFRSF8
11 extragonadal germ cell cancer 10.3 AFP POU5F1
12 embryonal testis carcinoma 10.3 AFP POU5F1
13 seminal vesicle tumor 10.3 AFP GPC3
14 ovarian endodermal sinus tumor 10.3 AFP GPC3
15 malignant teratoma 10.3 AFP POU5F1
16 mature teratoma 10.3 AFP POU5F1
17 ovarian primitive germ cell tumor 10.2 AFP GPC3
18 pineoblastoma 10.1 AFP POU5F1
19 bile duct adenocarcinoma 10.1 AFP GPC3
20 mixed germ cell cancer 10.1 AFP POU5F1
21 malignant leydig cell tumor 10.1 POU5F1 TNFRSF8
22 physical disorder 10.0 AFP NODAL
23 non-functioning pancreatic endocrine tumor 9.9 POU5F1 SOX2
24 testicular yolk sac tumor 9.8 AFP GPC3 POU5F1
25 intratubular embryonal carcinoma 9.8 AFP POU5F1 TNFRSF8
26 testicular infarct 9.8 AFP POU5F1 TNFRSF8
27 endodermal sinus tumor 9.8
28 seminoma 9.7 AFP POU5F1 TNFRSF8
29 ocular cancer 9.7 POU5F1 SOX2
30 central nervous system germ cell tumor 9.7 AFP POU5F1 SOX2
31 testicular germ cell tumor 9.6 AFP GPC3
32 cell type cancer 9.6 AFP POU5F1 SOX2
33 teratocarcinoma 9.2 NANOG POU5F1
34 venous hemangioma 9.1 NANOG POU5F1 SOX2
35 brain cancer 8.9 NANOG POU5F1 SOX2
36 germ cell and embryonal cancer 8.7 AFP NANOG POU5F1 SOX2
37 extragonadal seminoma 8.1 AFP NANOG POU5F1 SOX2 TNFRSF8

Graphical network of the top 20 diseases related to Ovarian Embryonal Carcinoma:



Diseases related to Ovarian Embryonal Carcinoma

Symptoms & Phenotypes for Ovarian Embryonal Carcinoma

UMLS symptoms related to Ovarian Embryonal Carcinoma:


abdominal pain

MGI Mouse Phenotypes related to Ovarian Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 ICK NANOG NODAL POU5F1 SOX2 GPC3
2 digestive/alimentary MP:0005381 9.65 ICK NODAL POU5F1 SOX2 GPC3
3 craniofacial MP:0005382 9.62 GPC3 ICK NODAL SOX2
4 embryo MP:0005380 9.55 NANOG NODAL POU5F1 SOX2 GPC3
5 mortality/aging MP:0010768 9.5 ICK NANOG NODAL POU5F1 SOX2 AFP
6 reproductive system MP:0005389 9.02 NODAL POU5F1 AFP SOX2 GPC3

Drugs & Therapeutics for Ovarian Embryonal Carcinoma

Drugs for Ovarian Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
3
Ribavirin Approved Phase 3 36791-04-5 37542
4
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
5
Captopril Approved Phase 3 62571-86-2 44093
6
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
7
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
12
Palivizumab Approved, Investigational Phase 3 188039-54-5
13
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
14
Hydroxyitraconazole Phase 3
15 Alkylating Agents Phase 3,Phase 2
16
protease inhibitors Phase 3
17 Steroid Synthesis Inhibitors Phase 3
18 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
19 Cytochrome P-450 CYP3A Inhibitors Phase 3
20 HIV Protease Inhibitors Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Topoisomerase Inhibitors Phase 3
23 Hormone Antagonists Phase 3,Phase 1,Phase 2
24 Hormones Phase 3,Phase 1,Phase 2
25 Angiotensin-Converting Enzyme Inhibitors Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
27 Echinocandins Phase 3
28 Anti-Bacterial Agents Phase 3
29 Antibiotics, Antitubercular Phase 3
30 Antibodies Phase 3,Phase 1
31 Immunoglobulins Phase 3,Phase 1
32 Antibodies, Monoclonal Phase 3,Phase 1
33 Etoposide phosphate Phase 3
34 Antihypertensive Agents Phase 3
35 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
36 Anti-Infective Agents Phase 3,Phase 2
37 Antifungal Agents Phase 3
38 Antiparasitic Agents Phase 3
39 Antiprotozoal Agents Phase 3
40 Liposomal amphotericin B Phase 3
41 Antirheumatic Agents Phase 3
42 Antimetabolites Phase 3
43 Antiviral Agents Phase 3,Phase 2
44 Antimitotic Agents Phase 3,Phase 2,Phase 1
45 Antineoplastic Agents, Alkylating Phase 3,Phase 2
46 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
47 Podophyllotoxin Phase 3 518-28-5
48 Dermatologic Agents Phase 3
49 Keratolytic Agents Phase 3
50
Lenograstim Approved, Investigational Phase 2 135968-09-1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
17 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
20 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
21 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
22 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Ovarian Embryonal Carcinoma

Genetic Tests for Ovarian Embryonal Carcinoma

Anatomical Context for Ovarian Embryonal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Embryonal Carcinoma:

19
The Ovary

MalaCards organs/tissues related to Ovarian Embryonal Carcinoma:

41
Ovary, Bone Marrow, Bone, Colon, Brain, Small Intestine

Publications for Ovarian Embryonal Carcinoma

Articles related to Ovarian Embryonal Carcinoma:

# Title Authors Year
1
Ovarian Embryonal Carcinoma in a Dog. ( 29169625 )
2017
2
Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma. ( 20096442 )
2010

Variations for Ovarian Embryonal Carcinoma

Expression for Ovarian Embryonal Carcinoma

Search GEO for disease gene expression data for Ovarian Embryonal Carcinoma.

Pathways for Ovarian Embryonal Carcinoma

GO Terms for Ovarian Embryonal Carcinoma

Biological processes related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 NANOG NODAL POU5F1 SOX2
2 response to wounding GO:0009611 9.51 POU5F1 SOX2
3 negative regulation of epithelial cell proliferation GO:0050680 9.48 GPC3 SOX2
4 SMAD protein signal transduction GO:0060395 9.46 AFP NODAL
5 regulation of gene expression GO:0010468 9.46 ICK NANOG POU5F1 SOX2
6 regulation of signal transduction GO:0009966 9.43 GPC3 NODAL
7 somatic stem cell population maintenance GO:0035019 9.43 NANOG POU5F1 SOX2
8 multicellular organism development GO:0007275 9.43 ICK NANOG NODAL POU5F1 SOX2 TNFRSF8
9 stem cell population maintenance GO:0019827 9.4 NANOG NODAL
10 anterior/posterior axis specification GO:0009948 9.37 GPC3 NODAL
11 positive regulation of cell-cell adhesion GO:0022409 9.32 NODAL SOX2
12 endodermal cell fate specification GO:0001714 8.8 NANOG POU5F1 SOX2

Molecular functions related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA binding GO:0035198 8.62 POU5F1 SOX2

Sources for Ovarian Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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