MCID: OVR050
MIFTS: 31

Ovarian Embryonal Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Ovarian Embryonal Carcinoma

MalaCards integrated aliases for Ovarian Embryonal Carcinoma:

Name: Ovarian Embryonal Carcinoma 12 15 17 70
Embryonal Carcinoma of the Ovary 12
Embryonal Carcinoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5681
NCIt 50 C8108
SNOMED-CT 67 254872007
UMLS 70 C0346183

Summaries for Ovarian Embryonal Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the ovary.

MalaCards based summary : Ovarian Embryonal Carcinoma, also known as embryonal carcinoma of the ovary, is related to embryonal carcinoma and teratoma, and has symptoms including abdominal pain An important gene associated with Ovarian Embryonal Carcinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Embryonal Carcinoma

Diseases related to Ovarian Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 embryonal carcinoma 30.3 TNFRSF8 POU5F1 AFP
2 teratoma 29.5 POU5F1 GPC3 AFP
3 endodermal sinus tumor 29.5 TNFRSF8 GPC3 AFP
4 childhood ovarian embryonal carcinoma 11.6
5 situs inversus 10.2
6 germ cell cancer 10.2 POU5F1 AFP
7 pediatric testicular germ cell tumor 10.1 POU5F1 AFP
8 ovarian solid teratoma 10.1 TNFRSF8 AFP
9 dysgerminoma of ovary 10.1 POU5F1 AFP
10 intermediate malignant teratoma 10.1 TNFRSF8 AFP
11 germinoma 10.1 POU5F1 AFP
12 testicular infarct 10.1 TNFRSF8 AFP
13 central nervous system germ cell tumor 10.1 POU5F1 AFP
14 infected hydrocele 10.1 TNFRSF8 AFP
15 mixed germ cell cancer 10.1 TNFRSF8 AFP
16 brain germinoma 10.1 POU5F1 AFP
17 amenorrhea 10.1
18 dextrocardia with situs inversus 10.1
19 precocious puberty 10.1
20 mediastinal cancer 10.1 TNFRSF8 AFP
21 pineoblastoma 10.0 POU5F1 AFP
22 embryonal testis carcinoma 10.0 TNFRSF8 AFP
23 spermatocytoma 10.0 POU5F1 AFP
24 tyrosinemia 10.0 POU5F1 AFP
25 testicular yolk sac tumor 10.0
26 germ cells tumors 10.0
27 polyembryoma 10.0
28 mixed germ cell tumor 10.0
29 germ cell and embryonal cancer 9.9 POU5F1 AFP
30 intratubular embryonal carcinoma 9.9 TNFRSF8 POU5F1 AFP
31 mature teratoma 9.9 TNFRSF8 POU5F1 AFP
32 sclerosing hepatic carcinoma 9.9 GPC3 AFP
33 testicular disease 9.9 TNFRSF8 POU5F1 AFP
34 sarcomatous intrahepatic cholangiocarcinoma 9.9 GPC3 AFP
35 seminoma 9.9 TNFRSF8 POU5F1 AFP
36 liver leiomyosarcoma 9.9 GPC3 AFP
37 ovarian germ cell cancer 9.9 GPC3 AFP
38 seminal vesicle adenocarcinoma 9.9 GPC3 AFP
39 hepatoid adenocarcinoma 9.9 GPC3 AFP
40 liver benign neoplasm 9.8 GPC3 AFP
41 fibrolamellar carcinoma 9.8 GPC3 AFP
42 hepatocellular adenoma 9.8 GPC3 AFP
43 ovarian primitive germ cell tumor 9.7 POU5F1 GPC3 AFP
44 ovarian endodermal sinus tumor 9.7 POU5F1 GPC3 AFP
45 testicular malignant germ cell cancer 9.7 TNFRSF8 GPC3 AFP
46 intrahepatic cholangiocarcinoma 9.6 PROM1 GPC3 AFP
47 hepatoblastoma 9.6 PROM1 GPC3 AFP
48 leber plus disease 9.6 TNFRSF8 PROM1 AFP
49 bile duct adenocarcinoma 9.6 GPC3 AFP
50 ovarian gonadoblastoma 9.5 TNFRSF8 POU5F1 GPC3 AFP

Graphical network of the top 20 diseases related to Ovarian Embryonal Carcinoma:



Diseases related to Ovarian Embryonal Carcinoma

Symptoms & Phenotypes for Ovarian Embryonal Carcinoma

UMLS symptoms related to Ovarian Embryonal Carcinoma:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.1 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.1 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.1 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.1 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.1 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.1 AFP

Drugs & Therapeutics for Ovarian Embryonal Carcinoma

Drugs for Ovarian Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
6
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
9
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11 Immunoglobulins Phase 3
12 Anti-Infective Agents Phase 3
13 Antimetabolites Phase 3
14 Antibodies Phase 3
15 Antiviral Agents Phase 3
16 Antibodies, Monoclonal Phase 3
17 Antirheumatic Agents Phase 3
18 Alkylating Agents Phase 3
19 Immunosuppressive Agents Phase 3
20 Angiotensin-Converting Enzyme Inhibitors Phase 3
21 Immunologic Factors Phase 3
22 Antihypertensive Agents Phase 3
23 HIV Protease Inhibitors Phase 3
24
protease inhibitors Phase 3
25 Hormones Phase 3
26 Hormone Antagonists Phase 3
27 Liposomal amphotericin B Phase 3
28 Anti-Bacterial Agents Phase 3
29 Antiparasitic Agents Phase 3
30 Antifungal Agents Phase 3
31 Antiprotozoal Agents Phase 3
32 Amebicides Phase 3
33 Cytochrome P-450 CYP3A Inhibitors Phase 3
34
Hydroxyitraconazole Phase 3 108222
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
37
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
38
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
39
Ifosfamide Approved Phase 2 3778-73-2 3690
40
Lenograstim Approved, Investigational Phase 2 135968-09-1
41
Oprelvekin Approved, Investigational Phase 2 145941-26-0
42
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
43
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
44
Molgramostim Investigational Phase 2 99283-10-0
45 Angiogenesis Inhibitors Phase 2
46 Protein Kinase Inhibitors Phase 2
47 Tubulin Modulators Phase 2
48
Isophosphamide mustard Phase 2 100427
49 Antimitotic Agents Phase 2
50 Albumin-Bound Paclitaxel Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
2 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
4 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
7 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
8 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
9 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
10 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
11 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
12 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
13 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
14 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
15 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
16 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Ovarian Embryonal Carcinoma

Genetic Tests for Ovarian Embryonal Carcinoma

Anatomical Context for Ovarian Embryonal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Embryonal Carcinoma:

19
Ovary

MalaCards organs/tissues related to Ovarian Embryonal Carcinoma:

40
Ovary, Bone Marrow, Bone, Testis, Liver, Brain

Publications for Ovarian Embryonal Carcinoma

Articles related to Ovarian Embryonal Carcinoma:

(show all 29)
# Title Authors PMID Year
1
Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. 61
33142349 2020
2
Ovarian Embryonal Carcinoma in a Dog. 61
29169625 2017
3
TRA-1-60+, SSEA-4+, Oct4A+, Nanog+ Clones of Pluripotent Stem Cells in the Embryonal Carcinomas of the Ovaries. 61
23293749 2012
4
Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma. 61
20096442 2010
5
Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract. 61
20185298 2010
6
Endodermal sinus tumor and embryonal carcinoma of the ovary in a 53-year-old woman. 61
8898183 1996
7
[Pure embryonal carcinoma of the ovary. A review of the literature apropos of a case]. 61
8952646 1996
8
Familial clustering of malignant germ cell tumors and Langerhans' histiocytosis. 61
8137225 1994
9
[A case of embryonal carcinoma of the ovary occurred in a 50 year-old woman]. 61
1376760 1992
10
Embryonal carcinoma of the ovary: a six-year survival. 61
1690671 1990
11
[A case of ovarian germ cell tumor]. 61
2476076 1989
12
[Embryonal carcinoma of the ovary. Anatomo-clinical aspects and presentation of a case]. 61
2771137 1989
13
Alpha-fetoprotein producing endometrial adenocarcinoma: report of a case. 61
2450056 1988
14
[Significance of tumor markers in the treatment of patients with ovarian malignancies]. 61
2445293 1987
15
Treatment of murine intraperitoneal ovarian ascitic tumor with hematoporphyrin derivative and laser light. 61
4005837 1985
16
Endodermal sinus tumor and embryonal carcinoma of the ovary in children. 61
2580758 1985
17
A patient with situs inversus totalis and embryonal carcinoma of the ovary. 61
6500379 1984
18
Liver metastasis from embryonal carcinoma of the ovary with complete situs inversus. First reported case and review of literature. 61
6386265 1984
19
Alpha-fetoprotein and human chorionic gonadotropin in embryonal carcinoma of the ovary. An 8-year survival case. 61
6193860 1983
20
Comparative morphology of endodermal sinus tumor (Teilum) to human yolk sac and a proposal of endodermal cell tumor. 61
6188320 1983
21
[Clinicopathological study of ovarian embryonal carcinoma (Higuchi-Kato)]. 61
7130773 1982
22
Embryonal carcinoma of the ovary occurring with pregnancy. 61
881372 1977
23
[Embryonal carcinoma of the ovary]. 61
885364 1977
24
Embryonal carcinoma of the ovary: a clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis. 61
63319 1976
25
Advances in chemotherapy for gynecologic cancer. 61
1157027 1975
26
[Embryonal carcinoma of the ovary in pregnancy]. 61
5138019 1971
27
[Ovarian embryonal carcinoma and pregnancy. (Case report)]. 61
5841294 1965
28
Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary. 61
5318716 1965
29
Embryonal carcinoma of the ovary. 61
14479144 1962

Variations for Ovarian Embryonal Carcinoma

Expression for Ovarian Embryonal Carcinoma

Search GEO for disease gene expression data for Ovarian Embryonal Carcinoma.

Pathways for Ovarian Embryonal Carcinoma

Pathways related to Ovarian Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 PROM1 POU5F1 AFP
2 10.92 PROM1 POU5F1 AFP

GO Terms for Ovarian Embryonal Carcinoma

Sources for Ovarian Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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