MCID: OVR051
MIFTS: 41

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endodermal Sinus Tumor

MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 15
Endodermal Sinus Tumor of Ovary 12 74
Ovarian Yolk Sac Tumor 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5350
NCIt 51 C8107
UMLS 74 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

Disease Ontology : 12 An ovarian primitive germ cell tumor that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to endodermal sinus tumor and cystadenoma, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Bleomycin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are Decreased Aire reporter expression and cardiovascular system

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 31.1 AFP GPC3 SALL4 SERPINA1
2 cystadenoma 30.3 INHA KRT7
3 sex cord-gonadal stromal tumor 30.2 AFP INHA KRT7
4 childhood ovarian endodermal sinus tumor 12.7
5 glandular pattern ovarian yolk sac tumor 11.4
6 hepatoid pattern ovarian yolk sac tumor 11.4
7 polyvesicular vitelline pattern ovarian yolk sac tumor 11.4
8 mucinous cystadenofibroma 10.3 AFP SERPINA1
9 malignant teratoma 10.3 AFP SALL4
10 polyembryoma 10.3 AFP SERPINA1
11 intrahepatic bile duct adenoma 10.3 AFP KRT7
12 renal pelvis adenocarcinoma 10.3 AFP KRT7
13 intratubular embryonal carcinoma 10.3 AFP KRT7
14 bile duct cystadenocarcinoma 10.3 AFP KRT7
15 extragonadal seminoma 10.3 AFP SALL4
16 testicular malignant germ cell cancer 10.3 AFP GPC3
17 pancreatoblastoma 10.3 AFP SERPINA1
18 ovarian embryonal carcinoma 10.3 AFP GPC3
19 choriocarcinoma of the testis 10.3 AFP KRT7
20 adenomatoid tumor 10.3 AFP KRT7
21 hepatic adenomas, familial 10.3 AFP GPC3
22 adenocarcinoma 10.3
23 sertoli-leydig cell tumor 10.3 AFP KRT7
24 mixed cell type cancer 10.2 AFP KRT7
25 bile duct adenoma 10.2 EZH2 KRT7
26 orofaciodigital syndrome viii 10.2 AFP INHA
27 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 GPC3 SERPINA1
28 germ cell and embryonal cancer 10.2 AFP KRT7
29 placental site trophoblastic tumor 10.2 INHA SALL4
30 embryoma 10.1 AFP GPC3 SALL4
31 acinar cell carcinoma 10.1 AFP KRT7 SERPINA1
32 inverted papilloma 10.1 KRT7 MSX2
33 pancreatic mucinous cystadenoma 10.1 EZH2 KRT7
34 ovarian cancer 10.1
35 cardiac tamponade 10.1
36 pericarditis 10.1
37 endometriosis 10.1
38 mixed germ cell-sex cord neoplasm 10.1
39 teratoma 10.1
40 fibrosarcoma 10.1
41 ovarian epithelial cancer 10.1
42 precocious puberty 10.1
43 seminal vesicle tumor 10.1 AFP GPC3 KRT7
44 bile duct adenocarcinoma 10.1 AFP GPC3 KRT7
45 hepatoblastoma 10.1 AFP GPC3 KRT7
46 carotid artery dissection 10.1 GPC3 SERPINA1
47 gastrointestinal system cancer 10.1 AFP GPC3 KRT7
48 epithelioid sarcoma 10.1 KRT7 SALL4
49 ovarian germ cell cancer 10.0 AFP HLX KRT7 SALL4
50 epithelioid trophoblastic tumor 10.0 INHA KRT7 SALL4

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Aire reporter expression GR00304-A 8.8 MSX2 NKX2-5 SALL4

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 EZH2 GPC3 INHA MSX2 NKX2-5 SALL4
2 endocrine/exocrine gland MP:0005379 9.92 AFP EZH2 HLX HOXB7 INHA MSX2
3 digestive/alimentary MP:0005381 9.91 GPC3 HLX INHA MSX2 NKX2-5 SALL4
4 hematopoietic system MP:0005397 9.86 EZH2 GPC3 HLX HOXB7 INHA MSX2
5 homeostasis/metabolism MP:0005376 9.81 AFP EZH2 GPC3 HLX INHA KRT7
6 immune system MP:0005387 9.56 EZH2 GPC3 HOXB7 INHA MSX2 NKX2-5
7 skeleton MP:0005390 9.1 EZH2 GPC3 HOXB7 INHA MSX2 SALL4

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 441203 84093 2767
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Captopril Approved Phase 3 62571-86-2 44093
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
6
Palivizumab Approved, Investigational Phase 3 188039-54-5
7
Ribavirin Approved Phase 3 36791-04-5 37542
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
10
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
11
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
12
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 2826718 468682
13
Carboplatin Approved Phase 3,Phase 2 41575-94-4 38904 10339178 498142
14 Anti-Bacterial Agents Phase 3
15 Etoposide phosphate Phase 3
16 Topoisomerase Inhibitors Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
19 Antihypertensive Agents Phase 3
20 Antirheumatic Agents Phase 3
21 Alkylating Agents Phase 3,Phase 2
22 Immunologic Factors Phase 3,Phase 2,Phase 1
23 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
24 Angiotensin-Converting Enzyme Inhibitors Phase 3
25
protease inhibitors Phase 3
26 Antineoplastic Agents, Alkylating Phase 3,Phase 2
27 HIV Protease Inhibitors Phase 3
28 Antiviral Agents Phase 3,Phase 2
29 Immunoglobulins Phase 3,Phase 1
30 Antibodies, Monoclonal Phase 3,Phase 1
31 Antimetabolites Phase 3
32 Anti-Infective Agents Phase 3,Phase 2
33 Antibodies Phase 3,Phase 1
34 Hormone Antagonists Phase 3,Phase 1,Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
36 Antifungal Agents Phase 3
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
38 Hormones Phase 3,Phase 1,Phase 2
39 Steroid Synthesis Inhibitors Phase 3
40
Hydroxyitraconazole Phase 3
41 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 3
43 Cytochrome P-450 CYP3A Inhibitors Phase 3
44 Liposomal amphotericin B Phase 3
45 Antiprotozoal Agents Phase 3
46 Antiparasitic Agents Phase 3
47 Antimitotic Agents Phase 3,Phase 2,Phase 1
48 Dermatologic Agents Phase 3
49 Podophyllotoxin Phase 3 518-28-5
50 Keratolytic Agents Phase 3

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
17 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
20 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
21 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
22 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

42
Ovary, Bone, Bone Marrow, Brain, Colon, Breast, Small Intestine

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show all 21)
# Title Authors Year
1
Treatment of ovarian endodermal sinus tumor to preserve fertility. ( 23351423 )
2013
2
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. ( 21058449 )
2010
3
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. ( 18672645 )
2008
4
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. ( 18656249 )
2008
5
Ovarian endodermal sinus tumor in a 76-year-old woman. ( 14641700 )
2003
6
Ovarian endodermal sinus tumor in a postmenopausal woman. ( 11531302 )
2001
7
Management of ovarian endodermal sinus tumor. ( 9208488 )
1996
8
Recurrent ovarian endodermal sinus tumor: demonstration by computed tomography, magnetic resonance imaging, and positron emission tomography. ( 8542908 )
1995
9
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 1541445 )
1992
10
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 2050306 )
1991
11
Intestinal variant of ovarian endodermal sinus tumor. ( 2470657 )
1989
12
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 3169625 )
1988
13
Delivery following removal and chemotherapy of ovarian endodermal sinus tumor. ( 3632459 )
1987
14
Ovarian endodermal sinus tumor with intestinal differentiation. ( 2418946 )
1986
15
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 2430863 )
1986
16
A case of ovarian endodermal sinus tumor associated with pregnancy. ( 6719453 )
1984
17
Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. ( 6208090 )
1984
18
Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. ( 6198243 )
1984
19
[Clinical aspects of ovarian endodermal sinus tumor]. ( 6201575 )
1984
20
Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. ( 703993 )
1978
21
Endodermal sinus tumor of ovary--a case report. ( 4362180 )
1973

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 AFP NKX2-5 SERPINA1

GO Terms for Ovarian Endodermal Sinus Tumor

Cellular components related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.91 HLX HOXB7 MSX2 NKX2-5 SIRT1
2 negative regulation of transcription, DNA-templated GO:0045892 9.78 EZH2 MSX2 NKX2-5 SIRT1
3 positive regulation of cell proliferation GO:0008284 9.76 EZH2 HLX NKX2-5 SIRT1
4 regulation of transcription, DNA-templated GO:0006355 9.73 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
5 cellular protein metabolic process GO:0044267 9.67 AFP GPC3 SERPINA1
6 regulation of cell proliferation GO:0042127 9.58 EZH2 INHA SIRT1
7 negative regulation of transcription by RNA polymerase II GO:0000122 9.55 EZH2 MSX2 NKX2-5 SALL4 SIRT1
8 positive regulation of BMP signaling pathway GO:0030513 9.43 GPC3 MSX2
9 embryonic hindlimb morphogenesis GO:0035116 9.37 GPC3 MSX2
10 outflow tract septum morphogenesis GO:0003148 9.32 MSX2 NKX2-5
11 negative regulation of phosphorylation GO:0042326 8.96 INHA SIRT1
12 ovulation from ovarian follicle GO:0001542 8.62 AFP SIRT1

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 AFP EZH2 GPC3 HLX HOXB7 INHA
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.73 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
3 transcription factor binding GO:0008134 9.46 MSX2 NKX2-5 SALL4 SIRT1
4 sequence-specific DNA binding GO:0043565 9.02 EZH2 HLX HOXB7 MSX2 NKX2-5

Sources for Ovarian Endodermal Sinus Tumor

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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
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45 MeSH
46 MESH via Orphanet
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55 NINDS
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59 OMIM via Orphanet
63 PubMed
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70 SNOMED-CT via HPO
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72 TGDB
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75 UMLS via Orphanet
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