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MCID: OVR051
MIFTS: 30

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ovarian Endodermal Sinus Tumor

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MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 15
Endodermal Sinus Tumor of Ovary 12 72
Ovarian Yolk Sac Tumor 12 17

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5350
NCIt 50 C8107
UMLS 72 C0346188
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Summaries for Ovarian Endodermal Sinus Tumor

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Disease Ontology : 12 An ovarian primitive germ cell tumor that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to testicular germ cell tumor and endodermal sinus tumor, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein). The drugs Ribavirin and Palivizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow.

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Related Diseases for Ovarian Endodermal Sinus Tumor

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Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 30.4 GPC3 AFP
2 endodermal sinus tumor 30.1 SALL4 GPC3 AFP
3 malignant teratoma 29.8 SALL4 AFP
4 ovarian germ cell cancer 29.2 SALL4 HLX AFP
5 testicular yolk sac tumor 29.0 SALL4 GPC3 AFP
6 childhood ovarian endodermal sinus tumor 12.8
7 glandular pattern ovarian yolk sac tumor 11.6
8 hepatoid pattern ovarian yolk sac tumor 11.6
9 polyvesicular vitelline pattern ovarian yolk sac tumor 11.6
10 germ cells tumors 10.4
11 endometrial cancer 10.4
12 ovarian epithelial cancer 10.4
13 endometriosis 10.3
14 adenocarcinoma 10.3
15 mixed germ cell tumor 10.3
16 germ cell cancer 10.3
17 ovarian cancer 10.1
18 dowling-degos disease 1 10.1
19 cardiac tamponade 10.1
20 pericarditis 10.1
21 sex cord-gonadal stromal tumor 10.1
22 cystadenoma 10.1
23 dermoid cyst 10.1
24 cystic teratoma 10.1
25 endometrial adenocarcinoma 10.1
26 mixed germ cell-sex cord neoplasm 10.1
27 mucinous adenocarcinoma 10.1
28 fibrosarcoma 10.1
29 appendix adenocarcinoma 10.1
30 dysgerminoma 10.1
31 clear cell adenocarcinoma 10.1
32 mature teratoma 10.1
33 precocious puberty 10.1
34 rare tumor 10.1
35 overgrowth syndrome 10.1
36 idiopathic interstitial pneumonia 10.1
37 teratoma 10.1
38 pulmonary fibrosis 10.1
39 testicular malignant germ cell cancer 10.0 GPC3 AFP
40 ovarian embryonal carcinoma 10.0 GPC3 AFP
41 hepatic adenomas, familial 10.0 GPC3 AFP
42 seminal vesicle tumor 9.9 GPC3 AFP
43 bile duct adenocarcinoma 9.9 GPC3 AFP
44 hepatoblastoma 9.9 GPC3 AFP
45 gastrointestinal system cancer 9.8 GPC3 AFP
46 endocrine gland cancer 9.8 GPC3 AFP
47 extragonadal seminoma 9.7 SALL4 AFP
48 beckwith-wiedemann syndrome 9.7 GPC3 AFP
49 liver cirrhosis 9.6 GPC3 AFP
50 cholangiocarcinoma 9.4 GPC3 AFP

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor
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Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

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UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain
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Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

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Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 3 36791-04-5 37542
2
Palivizumab Approved, Investigational Phase 3 188039-54-5
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
10 Alkylating Agents Phase 3
11 Antineoplastic Agents, Alkylating Phase 3
12 Antibodies Phase 3
13 Antibodies, Monoclonal Phase 3
14 Immunoglobulins Phase 3
15 Antiviral Agents Phase 3
16 Antimetabolites Phase 3
17 Anti-Infective Agents Phase 3
18 Hormone Antagonists Phase 3
19 Hormones Phase 3
20 Immunosuppressive Agents Phase 3
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
22 Antihypertensive Agents Phase 3
23 HIV Protease Inhibitors Phase 3
24 Immunologic Factors Phase 3
25 Angiotensin-Converting Enzyme Inhibitors Phase 3
26
protease inhibitors Phase 3
27 Antirheumatic Agents Phase 3
28 14-alpha Demethylase Inhibitors Phase 3
29 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
30 Cytochrome P-450 CYP3A Inhibitors Phase 3
31 Antifungal Agents Phase 3
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 Steroid Synthesis Inhibitors Phase 3
34
Hydroxyitraconazole Phase 3
35 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
36 Liposomal amphotericin B Phase 3
37 Anti-Bacterial Agents Phase 3
38 Antiparasitic Agents Phase 3
39 Antiprotozoal Agents Phase 3
40
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
41
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
42
Ifosfamide Approved Phase 2 3778-73-2 3690
43
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
44
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
45
Oprelvekin Approved, Investigational Phase 2 145941-26-0
46
Lenograstim Approved, Investigational Phase 2 135968-09-1
47
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
48
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
49 Angiogenesis Inhibitors Phase 2
50 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
2 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
6 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
7 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
8 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
9 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
10 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
11 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
12 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
13 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
14 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
15 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
16 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

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Genetic Tests for Ovarian Endodermal Sinus Tumor

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Anatomical Context for Ovarian Endodermal Sinus Tumor

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MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

41
Ovary, Bone, Bone Marrow, Uterus, Testis
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Publications for Ovarian Endodermal Sinus Tumor

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Articles related to Ovarian Endodermal Sinus Tumor:

(show top 50) (show all 84)
# Title Authors PMID Year
1
Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report. 38
30630034 2019
2
Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy. 38
30581951 2019
3
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review. 38
30113473 2018
4
Ovarian Yolk Sac Tumors; Does Age Matter? 38
29194189 2018
5
Tumor lysis syndrome in a patient with ovarian yolk sac tumor. 38
29159262 2017
6
Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity. 38
29204510 2017
7
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. 38
28249923 2017
8
Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors. 38
27401840 2016
9
Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman. 38
26782153 2016
10
Is yolk sac tumor related to the pathophysiology of low birthweight? 38
26879004 2016
11
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center. 38
27104939 2016
12
Ovarian yolk sac tumor in postmenopausal females: a report of five cases and a literature review. 38
27352567 2016
13
Ovarian Yolk Sac Tumor with Granulomatous Reaction Resembling Tuberculosis - A Unique Presentation. 38
24585354 2016
14
CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis. 38
26074455 2015
15
Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor. 38
26798532 2015
16
Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis. 38
25469282 2015
17
Yolk sac tumor of the ovary in a young girl with tuberous sclerosis: A case report and review of the literature. 38
26075992 2014
18
A case of ovarian yolk sac tumor associated with endometrioid adenocarcinoma. 38
25426406 2014
19
Role of neoadjuvant chemotherapy in the management of advanced ovarian yolk sac tumor. 38
24582864 2014
20
Childhood ovarian malignancy. 38
24757335 2014
21
Ovarian yolk sac tumor associated with pregnancy: a case report and review of the literature. 38
25556285 2014
22
Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component. 38
25550883 2014
23
Primary omental yolk sac tumor. 38
24396822 2013
24
Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases. 38
23348213 2013
25
Treatment of ovarian endodermal sinus tumor to preserve fertility. 38
23351423 2013
26
Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. 38
23781595 2013
27
Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy. 38
22127348 2012
28
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. 38
22734844 2012
29
Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination. 38
22040835 2012
30
Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. 38
21150160 2011
31
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. 38
21058449 2010
32
Ovarian yolk sac tumor associated with major fibrosarcoma component in a 13-year-old girl. 38
20407325 2010
33
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman. 38
20882900 2010
34
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. 38
18656249 2008
35
Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. 38
18408223 2008
36
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. 38
18672645 2008
37
Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development. 38
18547965 2008
38
Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature. 38
17197899 2007
39
Cancer chronomics I. Origins of timed cancer treatment: early marker rhythm-guided individualized chronochemotherapy. 38
17228525 2006
40
Novel human alpha-fetoprotein mRNA isoform lacking exon 1 identified in ovarian yolk sac tumor. 38
15914041 2005
41
Cytologic features of functioning stromal cells in a yolk sac tumor of the ovary. A case report. 38
14969187 2004
42
Ovarian yolk sac tumor associated with endometrioid carcinoma and mucinous cystadenoma of the ovary. 38
14571433 2003
43
Ovarian endodermal sinus tumor in a 76-year-old woman. 38
14641700 2003
44
Ovarian germ cell malignancy and human immunodeficiency virus (HIV) infection: a case report. 38
12911735 2003
45
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor component in a postmenopausal woman. 38
12193212 2002
46
[Ovarian endodermal sinus tumor associated with pregnancy--a case report]. 38
12152296 2002
47
Sustained complete remission in a patient with platinum-resistant ovarian yolk sac tumor. 38
11520160 2001
48
Ovarian endodermal sinus tumor in a postmenopausal woman. 38
11531302 2001
49
Weaver syndrome with neuroblastoma and cardiovascular anomalies. 38
11241499 2001
50
Ovarian yolk sac tumor with virilization during pregnancy: immunohistochemical demonstration of Leydig cells as functioning stroma. 38
10886732 2000
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Variations for Ovarian Endodermal Sinus Tumor

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Expression for Ovarian Endodermal Sinus Tumor

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Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.
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Pathways for Ovarian Endodermal Sinus Tumor

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GO Terms for Ovarian Endodermal Sinus Tumor

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Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 8.62 GPC3 AFP
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Sources for Ovarian Endodermal Sinus Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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