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MCID: OVR051
MIFTS: 36

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ovarian Endodermal Sinus Tumor

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MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 15
Endodermal Sinus Tumor of Ovary 12 71
Ovarian Yolk Sac Tumor 12 17
Endodermal Sinus Tumour of Ovary 12
Ovarian Endodermal Sinus Tumour 12
Ovarian Yolk Sac Tumour 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5350
NCIt 50 C8107
SNOMED-CT 67 254876005
UMLS 71 C0346188
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Summaries for Ovarian Endodermal Sinus Tumor

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Disease Ontology : 12 An ovarian primitive germ cell tumor that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to endodermal sinus tumor and germ cell cancer, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cardiac Progenitor Differentiation. The drugs Caspofungin and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Ovarian Endodermal Sinus Tumor

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Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 31.0 SALL4 KRT7 GPC3 AFP
2 germ cell cancer 30.3 SALL4 POU5F1 AFP
3 benign teratoma 30.3 SALL4 KRT7 AFP
4 dysgerminoma 30.2 SALL4 KRT7 AFP
5 cystadenoma 30.1 KRT7 AFP
6 teratoma 30.0 POU5F1 KRT7 AFP
7 ovarian germ cell cancer 30.0 SALL4 KRT7 GPC3 AFP
8 malignant teratoma 29.8 SALL4 POU5F1 GPC3 AFP
9 mature teratoma 29.8 SALL4 POU5F1 KRT7 AFP
10 childhood ovarian endodermal sinus tumor 11.7
11 glandular pattern ovarian yolk sac tumor 11.3
12 hepatoid pattern ovarian yolk sac tumor 11.3
13 polyvesicular vitelline pattern ovarian yolk sac tumor 11.3
14 germ cells tumors 10.4
15 endometrial cancer 10.4
16 ovarian epithelial cancer 10.3
17 rare tumor 10.3
18 extragonadal seminoma 10.2 SALL4 AFP
19 sclerosing hepatic carcinoma 10.2 GPC3 AFP
20 choriocarcinoma of the testis 10.2 SALL4 AFP
21 mixed germ cell cancer 10.2 SALL4 AFP
22 rete testis neoplasm 10.2 KRT7 AFP
23 rete testis adenocarcinoma 10.2 KRT7 AFP
24 rectum neuroendocrine neoplasm 10.2 KRT7 AFP
25 renal pelvis adenocarcinoma 10.2 KRT7 AFP
26 bile duct cystadenocarcinoma 10.2 KRT7 AFP
27 epididymal neoplasm 10.2 KRT7 AFP
28 colonic lymphangioma 10.2 KRT7 AFP
29 middle ear adenocarcinoma 10.2 KRT7 AFP
30 liver sarcoma 10.2 KRT7 AFP
31 ovarian germ cell teratoma 10.2 KRT7 AFP
32 biliary tract benign neoplasm 10.2 KRT7 AFP
33 hepatoid adenocarcinoma 10.2 GPC3 AFP
34 middle ear carcinoma 10.2 KRT7 AFP
35 cervical clear cell adenocarcinoma 10.2 NAPSA AFP
36 mediastinal cancer 10.2 KRT7 AFP
37 epididymis adenocarcinoma 10.2 KRT7 AFP
38 epididymis cancer 10.2 KRT7 AFP
39 liver benign neoplasm 10.2 GPC3 AFP
40 bile duct cysts 10.2 KRT7 AFP
41 anal fistula 10.2 KRT7 AFP
42 ovarian benign neoplasm 10.2 KRT7 AFP
43 intrahepatic bile duct adenoma 10.2 KRT7 AFP
44 klatskin's tumor 10.2 KRT7 AFP
45 epithelioid trophoblastic tumor 10.2 SALL4 KRT7
46 adenomatoid tumor 10.2 KRT7 AFP
47 placental site trophoblastic tumor 10.2 SALL4 GPC3
48 clear cell adenocarcinoma 10.1 NAPSA KRT7
49 bartholin's gland carcinoma 10.1 NAPSA KRT7
50 krukenberg carcinoma 10.1 NAPSA KRT7

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor
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Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

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UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP
8 Decreased Aire reporter expression GR00304-A 9.13 NKX2-5 POU5F1 SALL4

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GPC3 HLX NKX2-5 POU5F1 SALL4
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Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

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Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
2
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
3
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5
Palivizumab Approved, Investigational Phase 3 188039-54-5
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
8
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Captopril Approved Phase 3 62571-86-2 44093
11 Antifungal Agents Phase 3
12 Amebicides Phase 3
13 Anti-Infective Agents Phase 3
14 Antiparasitic Agents Phase 3
15 Liposomal amphotericin B Phase 3
16 Antiprotozoal Agents Phase 3
17 Anti-Bacterial Agents Phase 3
18 Immunologic Factors Phase 3
19 Immunoglobulins Phase 3
20 Antimetabolites Phase 3
21 Antibodies Phase 3
22 Antiviral Agents Phase 3
23 Antibodies, Monoclonal Phase 3
24 Hormones Phase 3
25 Hormone Antagonists Phase 3
26 Immunosuppressive Agents Phase 3
27
Hydroxyitraconazole Phase 3 108222
28 Cytochrome P-450 CYP3A Inhibitors Phase 3
29 Cytochrome P-450 Enzyme Inhibitors Phase 3
30 Angiotensin-Converting Enzyme Inhibitors Phase 3
31 Antihypertensive Agents Phase 3
32 Antirheumatic Agents Phase 3
33 HIV Protease Inhibitors Phase 3
34
protease inhibitors Phase 3
35 Alkylating Agents Phase 3
36
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
37
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
38
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
39
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
40
Lenograstim Approved, Investigational Phase 2 135968-09-1
41
Oprelvekin Approved, Investigational Phase 2 145941-26-0
42
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
43
Ifosfamide Approved Phase 2 3778-73-2 3690
44 Molgramostim Investigational Phase 2 99283-10-0
45 Angiogenesis Inhibitors Phase 2
46 Protein Kinase Inhibitors Phase 2
47 Anti-Asthmatic Agents Phase 1, Phase 2
48 Anti-Inflammatory Agents Phase 1, Phase 2
49 Respiratory System Agents Phase 1, Phase 2
50 glucocorticoids Phase 1, Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
2 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
3 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
4 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
7 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
8 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
9 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
10 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
11 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
12 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
13 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
14 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
15 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465
16 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

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Genetic Tests for Ovarian Endodermal Sinus Tumor

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Anatomical Context for Ovarian Endodermal Sinus Tumor

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MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

40
Ovary, Bone Marrow, Bone, Uterus, Testis
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Publications for Ovarian Endodermal Sinus Tumor

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Articles related to Ovarian Endodermal Sinus Tumor:

(show top 50) (show all 87)
# Title Authors PMID Year
1
Molecular Characterization of Ovarian Yolk Sac Tumor (OYST). 61
33435376 2021
2
Ovarian yolk sac tumor with epithelial tumor component in a postmenopausal woman - case report and literature review. 61
33042351 2020
3
Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor. 61
31910193 2019
4
Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report. 61
30630034 2019
5
Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy. 61
30581951 2019
6
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review. 61
30113473 2018
7
Ovarian Yolk Sac Tumors; Does Age Matter? 61
29194189 2018
8
Tumor lysis syndrome in a patient with ovarian yolk sac tumor. 61
29159262 2017
9
Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity. 61
29204510 2017
10
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. 61
28249923 2017
11
Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors. 61
27401840 2016
12
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center. 61
27104939 2016
13
Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman. 61
26782153 2016
14
Is yolk sac tumor related to the pathophysiology of low birthweight? 61
26879004 2016
15
Ovarian Yolk Sac Tumor with Granulomatous Reaction Resembling Tuberculosis - A Unique Presentation. 61
24585354 2016
16
Ovarian yolk sac tumor in postmenopausal females: a report of five cases and a literature review. 61
27352567 2016
17
CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis. 61
26074455 2015
18
Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis. 61
25469282 2015
19
Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor. 61
26798532 2015
20
Yolk sac tumor of the ovary in a young girl with tuberous sclerosis: A case report and review of the literature. 61
26075992 2014
21
A case of ovarian yolk sac tumor associated with endometrioid adenocarcinoma. 61
25426406 2014
22
Role of neoadjuvant chemotherapy in the management of advanced ovarian yolk sac tumor. 61
24582864 2014
23
Childhood ovarian malignancy. 61
24757335 2014
24
Ovarian yolk sac tumor associated with pregnancy: a case report and review of the literature. 61
25556285 2014
25
Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component. 61
25550883 2014
26
Primary omental yolk sac tumor. 61
24396822 2013
27
Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases. 61
23348213 2013
28
Treatment of ovarian endodermal sinus tumor to preserve fertility. 61
23351423 2013
29
Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. 61
23781595 2013
30
Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy. 61
22127348 2012
31
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. 61
22734844 2012
32
Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination. 61
22040835 2012
33
Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. 61
21150160 2011
34
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. 61
21058449 2010
35
Ovarian yolk sac tumor associated with major fibrosarcoma component in a 13-year-old girl. 61
20407325 2010
36
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman. 61
20882900 2010
37
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. 61
18656249 2008
38
Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. 61
18408223 2008
39
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. 61
18672645 2008
40
Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development. 61
18547965 2008
41
Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature. 61
17197899 2007
42
Cancer chronomics I. Origins of timed cancer treatment: early marker rhythm-guided individualized chronochemotherapy. 61
17228525 2006
43
Novel human alpha-fetoprotein mRNA isoform lacking exon 1 identified in ovarian yolk sac tumor. 61
15914041 2005
44
Cytologic features of functioning stromal cells in a yolk sac tumor of the ovary. A case report. 61
14969187 2004
45
Ovarian yolk sac tumor associated with endometrioid carcinoma and mucinous cystadenoma of the ovary. 61
14571433 2003
46
Ovarian endodermal sinus tumor in a 76-year-old woman. 61
14641700 2003
47
Ovarian germ cell malignancy and human immunodeficiency virus (HIV) infection: a case report. 61
12911735 2003
48
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor component in a postmenopausal woman. 61
12193212 2002
49
[Ovarian endodermal sinus tumor associated with pregnancy--a case report]. 61
12152296 2002
50
Sustained complete remission in a patient with platinum-resistant ovarian yolk sac tumor. 61
11520160 2001
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Variations for Ovarian Endodermal Sinus Tumor

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Expression for Ovarian Endodermal Sinus Tumor

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Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.
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Pathways for Ovarian Endodermal Sinus Tumor

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Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Wnt / Hedgehog / Notch 4
11.39 POU5F1 NKX2-5 AFP
2
Cardiac Progenitor Differentiation 1
10.98 POU5F1 NKX2-5
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
10.92 POU5F1 NKX2-5 AFP
4
Transcriptional regulation of pluripotent stem cells 65
Show member pathways
 10.85 SALL4 POU5F1
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GO Terms for Ovarian Endodermal Sinus Tumor

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Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 8.96 SALL4 POU5F1
2 cellular protein metabolic process GO:0044267 8.8 NAPSA GPC3 AFP

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.8 SALL4 POU5F1 NKX2-5
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Sources for Ovarian Endodermal Sinus Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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