MCID: OVR051
MIFTS: 35

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Ovarian Endodermal Sinus Tumor

MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 11 14
Endodermal Sinus Tumor of Ovary 11 71
Ovarian Yolk Sac Tumor 11 16
Endodermal Sinus Tumour of Ovary 11
Ovarian Endodermal Sinus Tumour 11
Ovarian Yolk Sac Tumour 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5350
NCIt 49 C8107
SNOMED-CT 68 254876005
UMLS 71 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

Disease Ontology: 11 An ovarian primitive germ cell tumor that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary: Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to testicular yolk sac tumor and endodermal sinus tumor, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cardiac progenitor differentiation. The drugs Bleomycin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and testis, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 testicular yolk sac tumor 31.4 SALL4 GPC3 AFP
2 endodermal sinus tumor 30.6 SALL4 POU5F1 KRT7 GPC3 AFP
3 dysgerminoma 30.6 KRT7 AFP
4 appendix adenocarcinoma 30.3 PAX8 KRT7
5 papillary serous adenocarcinoma 30.3 PAX8 KRT7
6 serous cystadenocarcinoma 30.1 PAX8 NAPSA KRT7
7 teratoma 30.1 POU5F1 KRT7 AFP
8 large cell neuroendocrine carcinoma 30.1 NAPSA KRT7
9 benign teratoma 29.9 SALL4 PAX8 KRT7 AFP
10 endometrial adenocarcinoma 29.9 PAX8 KRT7
11 malignant teratoma 29.9 SALL4 POU5F1 GPC3 AFP
12 germ cell cancer 29.8 SALL4 POU5F1 NKX2-5 GPC3 AFP
13 mucinous adenocarcinoma 29.8 PAX8 NAPSA KRT7
14 ovarian germ cell cancer 29.2 SALL4 POU5F1 PAX8 KRT7 GPC3 AFP
15 mixed germ cell cancer 29.2 SALL4 POU5F1 PAX8 KRT7 GPC3 AFP
16 childhood ovarian endodermal sinus tumor 11.7
17 glandular pattern ovarian yolk sac tumor 11.4
18 hepatoid pattern ovarian yolk sac tumor 11.4
19 polyvesicular vitelline pattern ovarian yolk sac tumor 11.4
20 testicular germ cell tumor 10.8
21 endometrial cancer 10.5
22 germ cell tumor 10.4
23 ovarian epithelial cancer 10.4
24 sarcomatous intrahepatic cholangiocarcinoma 10.3 GPC3 AFP
25 adenocarcinoma 10.3
26 rare tumor 10.3
27 mixed hepatoblastoma 10.3 GPC3 AFP
28 testicular malignant germ cell cancer 10.3 GPC3 AFP
29 extragonadal seminoma 10.3 SALL4 AFP
30 malignant pineal area germ cell neoplasm 10.3 SALL4 AFP
31 rectum neuroendocrine neoplasm 10.2 KRT7 AFP
32 epididymal neoplasm 10.2 KRT7 AFP
33 mucinous ovarian cystadenoma 10.2 KRT7 AFP
34 ovarian cystadenoma 10.2 KRT7 AFP
35 colonic lymphangioma 10.2 KRT7 AFP
36 bile duct cystadenocarcinoma 10.2 KRT7 AFP
37 liver leiomyosarcoma 10.2 GPC3 AFP
38 sclerosing hepatic carcinoma 10.2 GPC3 AFP
39 middle ear adenocarcinoma 10.2 KRT7 AFP
40 sublingual gland adenoid cystic carcinoma 10.2 KRT7 GPC3
41 sublingual gland cancer 10.2 KRT7 GPC3
42 liver sarcoma 10.2 KRT7 AFP
43 biliary tract benign neoplasm 10.2 KRT7 AFP
44 anal fistula 10.2 KRT7 AFP
45 bile duct adenoma 10.2 KRT7 AFP
46 intrahepatic bile duct adenoma 10.2 KRT7 AFP
47 liver benign neoplasm 10.2 GPC3 AFP
48 bile duct cysts 10.2 KRT7 AFP
49 epithelioid trophoblastic tumor 10.2 SALL4 KRT7
50 mediastinal cancer 10.2 KRT7 AFP

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.58 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.58 POU5F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.58 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 KRT7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.58 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.58 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.58 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.58 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.58 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.58 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.58 KRT7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.58 KRT7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 KRT7 POU5F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.58 AFP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.58 KRT7
16 Decreased Aire reporter expression GR00304-A 9.13 NKX2-5 POU5F1 SALL4

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 3 9041-93-4, 11056-06-7 5360373
2
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
3
Cisplatin Approved Phase 3 15663-27-1 2767 5702198 441203
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Picropodophyllin Approved, Investigational Phase 3 518-28-5, 477-47-4 10607 72435
6 Dermatologic Agents Phase 3
7 Tubulin Modulators Phase 3
8
Etoposide phosphate Phase 3 16760419
9 Antimitotic Agents Phase 3
10 Keratolytic Agents Phase 3
11 Antibiotics, Antitubercular Phase 3
12 Anti-Bacterial Agents Phase 3
13
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
14
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
15
Ifosfamide Approved Phase 2 3778-73-2 3690
16
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
17
Lenograstim Approved, Investigational Phase 2 135968-09-1
18
Palifosfamide Investigational Phase 2 31645-39-3 100427
19 Immunologic Factors Phase 2
20 Adjuvants, Immunologic Phase 2
21 Antineoplastic Agents, Alkylating Phase 2
22 Alkylating Agents Phase 2
23 Albumin-Bound Paclitaxel Phase 2
24
Ipilimumab Approved Phase 1 477202-00-9
25 Antineoplastic Agents, Immunological Phase 1
26 Antibodies, Monoclonal Phase 1
27 Antibodies Phase 1
28 Immunoglobulins, Intravenous Phase 1
29 Immunoglobulins Phase 1
30 Immune Checkpoint Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Carboplatin;Cisplatin;Etoposide
3 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
4 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
5 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
6 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

Organs/tissues related to Ovarian Endodermal Sinus Tumor:

MalaCards : Ovary, Uterus, Testis

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show top 50) (show all 111)
# Title Authors PMID Year
1
Post-pubertal ovarian yolk sac tumor with unusual follicular growth pattern, simulating struma ovarii. 62
35730020 2022
2
Clinicopathological features, prognosis, and fertility outcomes in Chinese Han women treated for ovarian yolk sac tumor: A retrospective case series study from two tertiary-care academic medical centers. 62
35866762 2022
3
Establishment and characterization of an ovarian yolk sac tumor patient-derived xenograft model. 62
34031745 2021
4
Pregnancy and Delivery After Ovarian Yolk Sac Tumor: A Case Report. 62
34408122 2021
5
Ovarian yolk sac tumor in a patient with sexual differentiation disorder: a case description. 62
34249660 2021
6
[Ovarian yolk sac tumor with polyvesicular vitelline pattern: report of a case]. 62
34078067 2021
7
Ovarian yolk sac tumor. 62
33931463 2021
8
Molecular Characterization of Ovarian Yolk Sac Tumor (OYST). 62
33435376 2021
9
Double primary germ cell tumor in a 45 year old woman: one case report and literature review. 62
34900077 2021
10
A rare case of ovarian yolk sac tumour arising from mucinous adenocarcinoma in a 67-year-old woman. 62
31339396 2020
11
Ovarian yolk sac tumor with epithelial tumor component in a postmenopausal woman - case report and literature review. 62
33042351 2020
12
Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor. 62
31910193 2019
13
Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report. 62
30630034 2019
14
Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy. 62
30581951 2019
15
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review. 62
30113473 2018
16
Ovarian Yolk Sac Tumors; Does Age Matter? 62
29194189 2018
17
Tumor lysis syndrome in a patient with ovarian yolk sac tumor. 62
29159262 2017
18
Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity. 62
29204510 2017
19
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. 62
28249923 2017
20
Ovarian yolk sac tumour in a girl - case report. 62
28796980 2017
21
Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors. 62
27401840 2016
22
Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman. 62
26782153 2016
23
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center. 62
27104939 2016
24
Is yolk sac tumor related to the pathophysiology of low birthweight? 62
26879004 2016
25
Ovarian Yolk Sac Tumor with Granulomatous Reaction Resembling Tuberculosis - A Unique Presentation. 62
24585354 2016
26
Ovarian yolk sac tumor in postmenopausal females: a report of five cases and a literature review. 62
27352567 2016
27
CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis. 62
26074455 2015
28
Administration of standard-dose BEP regimen (bleomycin+etoposide+cisplatin) is essential for treatment of ovarian yolk sac tumour. 62
25559616 2015
29
Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis. 62
25469282 2015
30
Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor. 62
26798532 2015
31
Yolk sac tumor of the ovary in a young girl with tuberous sclerosis: A case report and review of the literature. 62
26075992 2014
32
A case of ovarian yolk sac tumor associated with endometrioid adenocarcinoma. 62
25426406 2014
33
Role of neoadjuvant chemotherapy in the management of advanced ovarian yolk sac tumor. 62
24582864 2014
34
Childhood ovarian malignancy. 62
24757335 2014
35
Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component. 62
25550883 2014
36
Ovarian yolk sac tumor associated with pregnancy: a case report and review of the literature. 62
25556285 2014
37
Primary omental yolk sac tumor. 62
24396822 2013
38
Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases. 62
23348213 2013
39
A case report of non-islet cell tumour hypoglycaemia associated with ovarian germ-cell tumour. 62
23128903 2013
40
Treatment of ovarian endodermal sinus tumor to preserve fertility. 62
23351423 2013
41
Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. 62
23781595 2013
42
Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy. 62
22127348 2012
43
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. 62
22734844 2012
44
Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination. 62
22040835 2012
45
[Ovarian yolk sac tumour: general review]. 62
21708513 2011
46
Prognostic factors in women treated for ovarian yolk sac tumour: a retrospective analysis of 84 cases. 62
20851596 2011
47
Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. 62
21150160 2011
48
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. 62
21058449 2010
49
Ovarian yolk sac tumor associated with major fibrosarcoma component in a 13-year-old girl. 62
20407325 2010
50
Glypican 3 has a higher sensitivity than alpha-fetoprotein for testicular and ovarian yolk sac tumour: immunohistochemical investigation with analysis of histological growth patterns. 62
20546340 2010

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 POU5F1 NKX2-5 AFP
2 10.98 POU5F1 NKX2-5
3 10.92 POU5F1 NKX2-5 AFP
4
Show member pathways
10.72 SALL4 POU5F1

GO Terms for Ovarian Endodermal Sinus Tumor

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anatomical structure morphogenesis GO:0009653 9.43 POU5F1 PAX8 GPC3
2 epithelial cell differentiation GO:0030855 9.02 PAX8 NKX2-5 GSTA1

Sources for Ovarian Endodermal Sinus Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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