MCID: OVR051
MIFTS: 36

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endodermal Sinus Tumor

MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 15
Endodermal Sinus Tumor of Ovary 12 71
Ovarian Yolk Sac Tumor 12 17
Endodermal Sinus Tumour of Ovary 12
Ovarian Endodermal Sinus Tumour 12
Ovarian Yolk Sac Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5350
NCIt 49 C8107
SNOMED-CT 67 254876005
UMLS 71 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

Disease Ontology : 12 An ovarian primitive germ cell tumor that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to testicular germ cell tumor and clear cell adenocarcinoma, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cardiac Progenitor Differentiation. The drugs Cyclophosphamide and Captopril have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 31.0 GPC3 AFP
2 clear cell adenocarcinoma 30.4 NAPSA KRT7
3 cystic teratoma 30.4 KRT7 AFP
4 benign teratoma 30.3 KRT7 AFP
5 germ cell cancer 30.3 SALL4 POU5F1 AFP
6 endodermal sinus tumor 30.3 SALL4 POU5F1 KRT7 GPC3 AFP
7 cystadenoma 30.1 KRT7 AFP
8 malignant teratoma 29.7 SALL4 POU5F1 GPC3 AFP
9 teratoma 29.6 POU5F1 KRT7 GPC3 AFP
10 mature teratoma 29.6 SALL4 POU5F1 KRT7 AFP
11 dysgerminoma 29.6 SALL4 POU5F1 KRT7 AFP
12 ovarian germ cell cancer 29.2 SALL4 POU5F1 KRT7 GPC3 AFP
13 childhood ovarian endodermal sinus tumor 12.8
14 glandular pattern ovarian yolk sac tumor 11.6
15 hepatoid pattern ovarian yolk sac tumor 11.6
16 polyvesicular vitelline pattern ovarian yolk sac tumor 11.6
17 germ cells tumors 10.4
18 endometrial cancer 10.4
19 ovarian epithelial cancer 10.4
20 extragonadal seminoma 10.3 SALL4 AFP
21 choriocarcinoma of the testis 10.3 SALL4 AFP
22 sclerosing hepatic carcinoma 10.3 GPC3 AFP
23 childhood endodermal sinus tumor 10.3 SALL4 AFP
24 mixed germ cell cancer 10.3 SALL4 AFP
25 intrahepatic bile duct adenoma 10.3 KRT7 AFP
26 rete testis neoplasm 10.3 KRT7 AFP
27 rete testis adenocarcinoma 10.3 KRT7 AFP
28 rectum neuroendocrine neoplasm 10.3 KRT7 AFP
29 renal pelvis adenocarcinoma 10.3 KRT7 AFP
30 epididymal neoplasm 10.3 KRT7 AFP
31 bile duct cystadenocarcinoma 10.3 KRT7 AFP
32 colonic lymphangioma 10.3 KRT7 AFP
33 middle ear adenocarcinoma 10.3 KRT7 AFP
34 liver sarcoma 10.3 KRT7 AFP
35 adenocarcinoma 10.3
36 mixed germ cell tumor 10.3
37 rare tumor 10.3
38 benign mesothelioma 10.3 KRT7 AFP
39 spermatocytoma 10.3 SALL4 AFP
40 biliary tract benign neoplasm 10.3 KRT7 AFP
41 ovarian germ cell teratoma 10.3 KRT7 AFP
42 cystadenofibroma 10.3 KRT7 AFP
43 cervical clear cell adenocarcinoma 10.3 NAPSA AFP
44 liver benign neoplasm 10.3 GPC3 AFP
45 epididymis adenocarcinoma 10.2 KRT7 AFP
46 epididymis cancer 10.2 KRT7 AFP
47 middle ear carcinoma 10.2 KRT7 AFP
48 bile duct cysts 10.2 KRT7 AFP
49 mediastinal cancer 10.2 KRT7 AFP
50 germinoma 10.2 POU5F1 AFP

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP
8 Decreased Aire reporter expression GR00304-A 9.13 NKX2-5 POU5F1 SALL4

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GPC3 HLX NKX2-5 POU5F1 SALL4

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
2
Captopril Approved Phase 3 62571-86-2 44093
3
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
4
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
7
Ribavirin Approved Phase 3 36791-04-5 37542
8
Palivizumab Approved, Investigational Phase 3 188039-54-5
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
10
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
11 Alkylating Agents Phase 3
12 Immunologic Factors Phase 3
13 Antihypertensive Agents Phase 3
14 Immunosuppressive Agents Phase 3
15 Angiotensin-Converting Enzyme Inhibitors Phase 3
16 HIV Protease Inhibitors Phase 3
17
protease inhibitors Phase 3
18 Antirheumatic Agents Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Anti-Infective Agents Phase 3
21 Hormone Antagonists Phase 3
22 Hormones Phase 3
23
Hydroxyitraconazole Phase 3
24 Antifungal Agents Phase 3
25 Cytochrome P-450 CYP3A Inhibitors Phase 3
26 Immunoglobulins Phase 3
27 Antibodies Phase 3
28 Antiviral Agents Phase 3
29 Antibodies, Monoclonal Phase 3
30 Antimetabolites Phase 3
31 Amebicides Phase 3
32 Antiparasitic Agents Phase 3
33 Anti-Bacterial Agents Phase 3
34 Antiprotozoal Agents Phase 3
35 Liposomal amphotericin B Phase 3
36
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
37
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
38
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
39
Ifosfamide Approved Phase 2 3778-73-2 3690
40
Lenograstim Approved, Investigational Phase 2 135968-09-1
41
Oprelvekin Approved, Investigational Phase 2 145941-26-0
42
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
43
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
44 Molgramostim Investigational Phase 2 99283-10-0
45 Protein Kinase Inhibitors Phase 2
46 Angiogenesis Inhibitors Phase 2
47 Albumin-Bound Paclitaxel Phase 2
48 Tubulin Modulators Phase 2
49 Antimitotic Agents Phase 2
50
Isophosphamide mustard Phase 2 0

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
3 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
4 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
5 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
7 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
8 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
9 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
10 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
11 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
12 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
13 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
14 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
15 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
16 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

40
Ovary, Bone Marrow, Bone, Uterus, Testis

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show top 50) (show all 86)
# Title Authors PMID Year
1
Imaging in gynecological disease: ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors). 61
32119168 2020
2
Acute abdominal pain in an adolescent girl with an ovarian yolk sac tumor. 61
31910193 2019
3
Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report. 61
30630034 2019
4
Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy. 61
30581951 2019
5
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review. 61
30113473 2018
6
Ovarian Yolk Sac Tumors; Does Age Matter? 61
29194189 2018
7
Tumor lysis syndrome in a patient with ovarian yolk sac tumor. 61
29159262 2017
8
Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity. 61
29204510 2017
9
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. 61
28249923 2017
10
Prognostic significance of an early decline in serum alpha-fetoprotein during chemotherapy for ovarian yolk sac tumors. 61
27401840 2016
11
Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman. 61
26782153 2016
12
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center. 61
27104939 2016
13
Is yolk sac tumor related to the pathophysiology of low birthweight? 61
26879004 2016
14
Ovarian yolk sac tumor in postmenopausal females: a report of five cases and a literature review. 61
27352567 2016
15
Ovarian Yolk Sac Tumor with Granulomatous Reaction Resembling Tuberculosis - A Unique Presentation. 61
24585354 2016
16
CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis. 61
26074455 2015
17
Bleomycin-Induced Flagellate Erythema in a Patient Diagnosed with Ovarian Yolk Sac Tumor. 61
26798532 2015
18
Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis. 61
25469282 2015
19
Yolk sac tumor of the ovary in a young girl with tuberous sclerosis: A case report and review of the literature. 61
26075992 2014
20
A case of ovarian yolk sac tumor associated with endometrioid adenocarcinoma. 61
25426406 2014
21
Role of neoadjuvant chemotherapy in the management of advanced ovarian yolk sac tumor. 61
24582864 2014
22
Childhood ovarian malignancy. 61
24757335 2014
23
Bilateral ovarian mixed epithelial adenocarcinoma in a postmenopausal woman with unilateral ovarian yolk sac tumor component. 61
25550883 2014
24
Ovarian yolk sac tumor associated with pregnancy: a case report and review of the literature. 61
25556285 2014
25
Primary omental yolk sac tumor. 61
24396822 2013
26
Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases. 61
23348213 2013
27
Treatment of ovarian endodermal sinus tumor to preserve fertility. 61
23351423 2013
28
Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. 61
23781595 2013
29
Bleomycin-induced pulmonary fibrosis after tumor lysis syndrome in a case of advanced yolk sac tumor treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy. 61
22127348 2012
30
Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report. 61
22734844 2012
31
Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination. 61
22040835 2012
32
Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. 61
21150160 2011
33
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. 61
21058449 2010
34
Ovarian yolk sac tumor associated with major fibrosarcoma component in a 13-year-old girl. 61
20407325 2010
35
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor in a 35-year-old woman. 61
20882900 2010
36
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. 61
18656249 2008
37
Survival and reproductive function of 52 women treated with surgery and bleomycin, etoposide, cisplatin (BEP) chemotherapy for ovarian yolk sac tumor. 61
18408223 2008
38
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. 61
18672645 2008
39
Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development. 61
18547965 2008
40
Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature. 61
17197899 2007
41
Cancer chronomics I. Origins of timed cancer treatment: early marker rhythm-guided individualized chronochemotherapy. 61
17228525 2006
42
Novel human alpha-fetoprotein mRNA isoform lacking exon 1 identified in ovarian yolk sac tumor. 61
15914041 2005
43
Cytologic features of functioning stromal cells in a yolk sac tumor of the ovary. A case report. 61
14969187 2004
44
Ovarian yolk sac tumor associated with endometrioid carcinoma and mucinous cystadenoma of the ovary. 61
14571433 2003
45
Ovarian endodermal sinus tumor in a 76-year-old woman. 61
14641700 2003
46
Ovarian germ cell malignancy and human immunodeficiency virus (HIV) infection: a case report. 61
12911735 2003
47
A case of ovarian endometrioid adenocarcinoma with yolk sac tumor component in a postmenopausal woman. 61
12193212 2002
48
[Ovarian endodermal sinus tumor associated with pregnancy--a case report]. 61
12152296 2002
49
Sustained complete remission in a patient with platinum-resistant ovarian yolk sac tumor. 61
11520160 2001
50
Ovarian endodermal sinus tumor in a postmenopausal woman. 61
11531302 2001

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 POU5F1 NKX2-5 AFP
2 10.98 POU5F1 NKX2-5
3 10.92 POU5F1 NKX2-5 AFP
4
Show member pathways
10.85 SALL4 POU5F1

GO Terms for Ovarian Endodermal Sinus Tumor

Cellular components related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 POU5F1 NKX2-5 KAT7 HLX

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.35 SALL4 POU5F1 NKX2-5 KAT7 HLX
2 somatic stem cell population maintenance GO:0035019 9.16 SALL4 POU5F1
3 cellular protein metabolic process GO:0044267 8.8 NAPSA GPC3 AFP

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 8.92 SALL4 POU5F1 NKX2-5 KAT7

Sources for Ovarian Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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