MCID: OVR051
MIFTS: 41

Ovarian Endodermal Sinus Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endodermal Sinus Tumor

MalaCards integrated aliases for Ovarian Endodermal Sinus Tumor:

Name: Ovarian Endodermal Sinus Tumor 12 15
Endodermal Sinus Tumor of Ovary 12 73
Ovarian Yolk Sac Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5350
NCIt 50 C8107
UMLS 73 C0346188

Summaries for Ovarian Endodermal Sinus Tumor

Disease Ontology : 12 An ovarian primitive germ cell tumor that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Ovarian Endodermal Sinus Tumor, also known as endodermal sinus tumor of ovary, is related to endodermal sinus tumor and childhood ovarian endodermal sinus tumor, and has symptoms including abdominal pain An important gene associated with Ovarian Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. The drugs Bleomycin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are Decreased Aire reporter expression and endocrine/exocrine gland

Related Diseases for Ovarian Endodermal Sinus Tumor

Diseases related to Ovarian Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 31.1 AFP GPC3 SALL4 SERPINA1
2 childhood ovarian endodermal sinus tumor 12.7
3 glandular pattern ovarian yolk sac tumor 11.4
4 hepatoid pattern ovarian yolk sac tumor 11.4
5 polyvesicular vitelline pattern ovarian yolk sac tumor 11.4
6 adenocarcinoma 10.3
7 mucinous cystadenofibroma 10.2 AFP SERPINA1
8 polyembryoma 10.2 AFP SERPINA1
9 malignant teratoma 10.2 AFP SALL4
10 intrahepatic bile duct adenoma 10.2 AFP KRT7
11 renal pelvis adenocarcinoma 10.2 AFP KRT7
12 intratubular embryonal carcinoma 10.2 AFP KRT7
13 bile duct cystadenocarcinoma 10.2 AFP KRT7
14 testicular malignant germ cell cancer 10.2 AFP GPC3
15 extragonadal seminoma 10.2 AFP SALL4
16 pancreatoblastoma 10.2 AFP SERPINA1
17 ovarian embryonal carcinoma 10.2 AFP GPC3
18 choriocarcinoma of the testis 10.2 AFP KRT7
19 adenomatoid tumor 10.2 AFP KRT7
20 epithelioid trophoblastic tumor 10.2 KRT7 SALL4
21 hepatic adenomas, familial 10.2 AFP GPC3
22 sertoli-leydig cell tumor 10.2 AFP KRT7
23 mixed cell type cancer 10.1 AFP KRT7
24 bile duct adenoma 10.1 EZH2 KRT7
25 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 GPC3 SERPINA1
26 ovarian cancer 10.1
27 cardiac tamponade 10.1
28 pericarditis 10.1
29 sex cord-gonadal stromal tumor 10.1
30 cystadenoma 10.1
31 endometriosis 10.1
32 mixed germ cell-sex cord neoplasm 10.1
33 fibrosarcoma 10.1
34 ovarian epithelial cancer 10.1
35 precocious puberty 10.1
36 germ cell and embryonal cancer 10.1 AFP KRT7
37 granulosa cell tumor of the ovary 10.1 KRT7 SERPINA1
38 embryoma 10.1 AFP GPC3 SALL4
39 cystadenofibroma 10.1 AFP KRT7 SERPINA1
40 acinar cell carcinoma 10.1 AFP KRT7 SERPINA1
41 pancreatic mucinous cystadenoma 10.1 EZH2 KRT7
42 seminal vesicle tumor 10.1 AFP GPC3 KRT7
43 bile duct adenocarcinoma 10.1 AFP GPC3 KRT7
44 hepatoblastoma 10.1 AFP GPC3 KRT7
45 gastrointestinal system cancer 10.0 AFP GPC3 KRT7
46 inverted papilloma 10.0 KRT7 MSX2
47 carotid artery dissection 10.0 GPC3 SERPINA1
48 ovarian germ cell cancer 10.0 AFP HLX KRT7 SALL4
49 epithelioid sarcoma 10.0 KRT7 SALL4
50 liver cirrhosis 10.0 AFP GPC3 SERPINA1

Graphical network of the top 20 diseases related to Ovarian Endodermal Sinus Tumor:



Diseases related to Ovarian Endodermal Sinus Tumor

Symptoms & Phenotypes for Ovarian Endodermal Sinus Tumor

UMLS symptoms related to Ovarian Endodermal Sinus Tumor:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Aire reporter expression GR00304-A 8.8 MSX2 NKX2-5 SALL4

MGI Mouse Phenotypes related to Ovarian Endodermal Sinus Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 AFP EZH2 HLX HOXB7 KPNA1 MSX2
2 digestive/alimentary MP:0005381 9.73 GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
3 hematopoietic system MP:0005397 9.56 EZH2 GPC3 HLX HOXB7 KPNA1 MSX2
4 homeostasis/metabolism MP:0005376 9.28 AFP EZH2 GPC3 HLX KPNA1 KRT7

Drugs & Therapeutics for Ovarian Endodermal Sinus Tumor

Drugs for Ovarian Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
5
Captopril Approved Phase 3 62571-86-2 44093
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Palivizumab Approved, Investigational Phase 3 188039-54-5
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
12
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
13
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
14 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
15 Etoposide phosphate Phase 3
16 Anti-Bacterial Agents Phase 3
17 Antibiotics, Antitubercular Phase 3
18 Topoisomerase Inhibitors Phase 3
19 Antihypertensive Agents Phase 3
20 Antineoplastic Agents, Alkylating Phase 3,Phase 2
21 Alkylating Agents Phase 3,Phase 2
22 Immunologic Factors Phase 3,Phase 2,Phase 1
23
protease inhibitors Phase 3
24 Antirheumatic Agents Phase 3
25 HIV Protease Inhibitors Phase 3
26 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
27 Angiotensin-Converting Enzyme Inhibitors Phase 3
28 Immunoglobulins Phase 3,Phase 1
29 Antimetabolites Phase 3
30 Antibodies Phase 3,Phase 1
31 Anti-Infective Agents Phase 3,Phase 2
32 Antibodies, Monoclonal Phase 3,Phase 1
33 Antiviral Agents Phase 3,Phase 2
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
35 Cytochrome P-450 CYP3A Inhibitors Phase 3
36 Steroid Synthesis Inhibitors Phase 3
37 Cytochrome P-450 Enzyme Inhibitors Phase 3
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
39
Hydroxyitraconazole Phase 3
40 Hormones Phase 3,Phase 1,Phase 2
41 Antifungal Agents Phase 3
42 Hormone Antagonists Phase 3,Phase 1,Phase 2
43 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
44 Liposomal amphotericin B Phase 3
45 Antiparasitic Agents Phase 3
46 Antiprotozoal Agents Phase 3
47 Echinocandins Phase 3
48 Antimitotic Agents Phase 3,Phase 2,Phase 1
49 Keratolytic Agents Phase 3
50 Podophyllotoxin Phase 3 518-28-5

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
4 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
5 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
6 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
7 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
8 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
9 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
10 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
11 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
12 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
13 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
14 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
15 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
16 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
17 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
18 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
19 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
20 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
21 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
22 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Ovarian Endodermal Sinus Tumor

Genetic Tests for Ovarian Endodermal Sinus Tumor

Anatomical Context for Ovarian Endodermal Sinus Tumor

MalaCards organs/tissues related to Ovarian Endodermal Sinus Tumor:

41
Ovary, Bone, Bone Marrow, Skin, Liver, Testis

Publications for Ovarian Endodermal Sinus Tumor

Articles related to Ovarian Endodermal Sinus Tumor:

(show all 21)
# Title Authors Year
1
Treatment of ovarian endodermal sinus tumor to preserve fertility. ( 23351423 )
2013
2
Ruptured ovarian endodermal sinus tumor diagnosed during pregnancy: case report and review of the literature. ( 21058449 )
2010
3
A case of ovarian endodermal sinus tumor diagnosed during pregnancy. ( 18672645 )
2008
4
Outcome and reproductive function after cumulative high-dose combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for patients with ovarian endodermal sinus tumor. ( 18656249 )
2008
5
Ovarian endodermal sinus tumor in a 76-year-old woman. ( 14641700 )
2003
6
Ovarian endodermal sinus tumor in a postmenopausal woman. ( 11531302 )
2001
7
Management of ovarian endodermal sinus tumor. ( 9208488 )
1996
8
Recurrent ovarian endodermal sinus tumor: demonstration by computed tomography, magnetic resonance imaging, and positron emission tomography. ( 8542908 )
1995
9
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 1541445 )
1992
10
Ovarian endodermal sinus tumor associated with pregnancy: review of the literature. ( 2050306 )
1991
11
Intestinal variant of ovarian endodermal sinus tumor. ( 2470657 )
1989
12
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 3169625 )
1988
13
Delivery following removal and chemotherapy of ovarian endodermal sinus tumor. ( 3632459 )
1987
14
Ovarian endodermal sinus tumor with intestinal differentiation. ( 2418946 )
1986
15
Establishment and characterization of a human ovarian endodermal sinus tumor cell line--producing specific type of alpha-fetoprotein subfraction. ( 2430863 )
1986
16
A case of ovarian endodermal sinus tumor associated with pregnancy. ( 6719453 )
1984
17
Normal pregnancy and delivery following conservative surgery and chemotherapy for ovarian endodermal sinus tumor. ( 6208090 )
1984
18
Serial serum determination on alpha-fetoprotein as a marker of the effect of postoperative chemotherapy in ovarian endodermal sinus tumor. ( 6198243 )
1984
19
[Clinical aspects of ovarian endodermal sinus tumor]. ( 6201575 )
1984
20
Pregnancy following removal and chemotherapy of ovarian endodermal sinus tumor. ( 703993 )
1978
21
Endodermal sinus tumor of ovary--a case report. ( 4362180 )
1973

Variations for Ovarian Endodermal Sinus Tumor

Expression for Ovarian Endodermal Sinus Tumor

Search GEO for disease gene expression data for Ovarian Endodermal Sinus Tumor.

Pathways for Ovarian Endodermal Sinus Tumor

Pathways related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Endodermal Sinus Tumor

Cellular components related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.95 HLX HOXB7 MSX2 NKX2-5 SIRT1
2 regulation of transcription, DNA-templated GO:0006355 9.88 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
3 negative regulation of transcription, DNA-templated GO:0045892 9.83 EZH2 MSX2 NKX2-5 SIRT1
4 positive regulation of cell proliferation GO:0008284 9.81 EZH2 HLX NKX2-5 SIRT1
5 negative regulation of transcription by RNA polymerase II GO:0000122 9.72 EZH2 MSX2 NKX2-5 SALL4 SIRT1
6 cellular protein metabolic process GO:0044267 9.71 AFP GPC3 SERPINA1
7 viral process GO:0016032 9.67 KPNA1 KPNA2 KRT7 SIRT1
8 positive regulation of BMP signaling pathway GO:0030513 9.49 GPC3 MSX2
9 embryonic hindlimb morphogenesis GO:0035116 9.48 GPC3 MSX2
10 outflow tract septum morphogenesis GO:0003148 9.46 MSX2 NKX2-5
11 NLS-bearing protein import into nucleus GO:0006607 9.43 KPNA1 KPNA2
12 postsynapse to nucleus signaling pathway GO:0099527 9.26 KPNA1 KPNA2
13 ovulation from ovarian follicle GO:0001542 9.16 AFP SIRT1
14 modulation by virus of host process GO:0019054 8.96 KPNA1 KPNA2
15 regulation of DNA recombination GO:0000018 8.62 KPNA1 KPNA2

Molecular functions related to Ovarian Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 AFP EZH2 GPC3 HLX HOXB7 KPNA1
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.8 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
3 transcription factor binding GO:0008134 9.56 MSX2 NKX2-5 SALL4 SIRT1
4 nuclear localization sequence binding GO:0008139 9.37 KPNA1 KPNA2
5 sequence-specific DNA binding GO:0043565 9.35 EZH2 HLX HOXB7 MSX2 NKX2-5
6 nuclear import signal receptor activity GO:0061608 8.62 KPNA1 KPNA2

Sources for Ovarian Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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