MCID: OVR103
MIFTS: 23

Ovarian Endometrial Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endometrial Cancer

MalaCards integrated aliases for Ovarian Endometrial Cancer:

Name: Ovarian Endometrial Cancer 12 15
Malignant Ovarian Endometrioid Tumor 12
Endometrioid Neoplasm of Ovary 12
Ovarian Endometrioid Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6212
NCIt 49 C40051 C6257
UMLS 71 C1335159 C1518231

Summaries for Ovarian Endometrial Cancer

Disease Ontology : 12 An ovary epithelial cancer that has material basis in the endometrium and is located in the ovary.

MalaCards based summary : Ovarian Endometrial Cancer, also known as malignant ovarian endometrioid tumor, is related to endometrioid ovary carcinoma and undifferentiated embryonal sarcoma of the liver. An important gene associated with Ovarian Endometrial Cancer is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1). The drugs Doxorubicin and Mesna have been mentioned in the context of this disorder. Affiliated tissues include ovary.

Related Diseases for Ovarian Endometrial Cancer

Diseases related to Ovarian Endometrial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 endometrioid ovary carcinoma 11.5
2 undifferentiated embryonal sarcoma of the liver 9.9 SERPINA3 MALAT1
3 embryonal sarcoma 9.9 SERPINA3 MALAT1
4 fibroma 9.8 SERPINA3 MALAT1
5 prostate disease 9.7 SERPINA3 MALAT1
6 gastrointestinal system cancer 9.7 SERPINA3 MALAT1
7 ovary adenocarcinoma 9.7 SERPINB11 SERPINA3
8 liver cirrhosis 9.5 SERPINA3 MALAT1

Graphical network of the top 20 diseases related to Ovarian Endometrial Cancer:



Diseases related to Ovarian Endometrial Cancer

Symptoms & Phenotypes for Ovarian Endometrial Cancer

Drugs & Therapeutics for Ovarian Endometrial Cancer

Drugs for Ovarian Endometrial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Mesna Approved, Investigational Phase 2 3375-50-6 598
3
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
4
Pembrolizumab Approved Phase 2 1374853-91-4
5
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
6
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
7
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
8
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
9
Cysteine Approved, Nutraceutical Phase 2 52-90-4 5862
10
Liposomal doxorubicin Phase 2 31703
11 Antineoplastic Agents, Immunological Phase 2
12 Anti-HIV Agents Phase 2
13 Alkylating Agents Phase 2
14 Immunosuppressive Agents Phase 2
15 Anti-Retroviral Agents Phase 2
16 Immunologic Factors Phase 2
17 Antirheumatic Agents Phase 2
18 Respiratory System Agents Phase 2
19 Anti-Infective Agents Phase 2
20 Antidotes Phase 2
21 Antioxidants Phase 2
22 Antiviral Agents Phase 2
23 topoisomerase I inhibitors Phase 2
24 Expectorants Phase 2
25 N-monoacetylcystine Phase 2
26 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antitumoral Activity and Safety of AEZS-108 (AN-152), a LHRH Agonist Linked Doxorubicin, in Women With LHRH Receptor Positive Gynecological Tumors Completed NCT00569257 Phase 2 AEZS-108
2 A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab Recruiting NCT01174121 Phase 2 Aldesleukin;Cyclophosphamide;Fludarabine;Pembrolizumab (Keytruda)
3 Evaluation of the Addition of N-Acetylcysteine to Topotecan in the Tumor Microenvironment of Persistent or Recurrent High Grade Endometrioid or Serous Ovarian Carcinoma Terminated NCT02569957 Phase 2 Topotecan Hydrochloride;Topotecan Hydrochloride;Acetylcysteine
4 Diagnosing Ovarian & Endometrial Cancer Early (DOvEE) by Targeting Symptomatic Women Recruiting NCT02296307

Search NIH Clinical Center for Ovarian Endometrial Cancer

Genetic Tests for Ovarian Endometrial Cancer

Anatomical Context for Ovarian Endometrial Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Endometrial Cancer:

19
Ovary

MalaCards organs/tissues related to Ovarian Endometrial Cancer:

40
Ovary

Publications for Ovarian Endometrial Cancer

Articles related to Ovarian Endometrial Cancer:

# Title Authors PMID Year
1
Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women's Health Initiative Observational Study. 61
31542834 2019
2
Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study. 61
29235567 2018
3
Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer. 61
27838886 2017
4
Clear cell carcinoma of ovary with squamous metaplasia: A unique histopathological observation. 61
22557790 2011
5
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer. 61
18794095 2008
6
Aromatase inhibitors: possible future applications. 61
15255840 2004

Variations for Ovarian Endometrial Cancer

Expression for Ovarian Endometrial Cancer

Search GEO for disease gene expression data for Ovarian Endometrial Cancer.

Pathways for Ovarian Endometrial Cancer

GO Terms for Ovarian Endometrial Cancer

Biological processes related to Ovarian Endometrial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 8.96 SERPINB11 SERPINA3
2 negative regulation of peptidase activity GO:0010466 8.62 SERPINB11 SERPINA3

Molecular functions related to Ovarian Endometrial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ligase activity GO:0016874 9.16 SARS2 PFAS
2 peptidase inhibitor activity GO:0030414 8.96 SERPINB11 SERPINA3
3 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINB11 SERPINA3

Sources for Ovarian Endometrial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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