MCID: OVR103
MIFTS: 29

Ovarian Endometrial Cancer

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Endometrial Cancer

MalaCards integrated aliases for Ovarian Endometrial Cancer:

Name: Ovarian Endometrial Cancer 12 15
Malignant Ovarian Endometrioid Tumor 12
Endometrioid Neoplasm of Ovary 12
Ovarian Endometrioid Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6212
NCIt 50 C40051 C6257
UMLS 71 C1335159 C1518231

Summaries for Ovarian Endometrial Cancer

Disease Ontology : 12 An ovary epithelial cancer that has material basis in the endometrium and is located in the ovary.

MalaCards based summary : Ovarian Endometrial Cancer, also known as malignant ovarian endometrioid tumor, is related to endometrioid ovary carcinoma and undifferentiated embryonal sarcoma of the liver. An important gene associated with Ovarian Endometrial Cancer is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways is Renin secretion. The drugs Acetylcysteine and Topotecan have been mentioned in the context of this disorder. Affiliated tissues include ovary.

Related Diseases for Ovarian Endometrial Cancer

Diseases related to Ovarian Endometrial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 endometrioid ovary carcinoma 11.3
2 undifferentiated embryonal sarcoma of the liver 10.4 SERPINA3 MALAT1
3 embryonal sarcoma 10.4 SERPINA3 MALAT1
4 congenital epulis 10.4 SERPINA3 PGR
5 epulis 10.4 SERPINA3 PGR
6 lung sarcoma 10.4 SERPINA3 NAPSA
7 glassy cell carcinoma of the cervix 10.4 PGR ESR1
8 breast intraductal papillomatosis 10.4 PGR ESR1
9 nipple carcinoma 10.4 PGR ESR1
10 bartholin's gland adenoma 10.4 PGR ESR1
11 uterine corpus adenosarcoma 10.4 PGR ESR1
12 bartholin's gland benign neoplasm 10.4 PGR ESR1
13 pleomorphic lipoma 10.4 SERPINA3 PGR
14 chronic tympanitis 10.4 PGR ESR1
15 vestibular gland benign neoplasm 10.4 PGR ESR1
16 vulvar syringoma 10.4 PGR ESR1
17 lung leiomyoma 10.4 PGR ESR1
18 adult type testicular granulosa cell tumor 10.4 PGR ESR1
19 skull base cancer 10.4 SERPINA3 PGR
20 breast scirrhous carcinoma 10.4 PGR ESR1
21 triple-receptor negative breast cancer 10.3 PGR MALAT1
22 breast papillary carcinoma 10.3 PGR ESR1
23 intravenous leiomyomatosis 10.3 PGR ESR1
24 comedo carcinoma 10.3 PGR ESR1
25 meningothelial meningioma 10.3 SERPINA3 PGR
26 breast adenoid cystic carcinoma 10.3 PGR ESR1
27 fallopian tube endometriosis 10.3 PGR CEACAM5
28 intracranial meningioma 10.3 PGR ESR1
29 vaginal glandular tumor 10.3 PGR CEACAM5
30 cervical serous adenocarcinoma 10.3 PGR CEACAM5
31 vulvar leiomyoma 10.3 PGR ESR1
32 bizarre leiomyoma 10.3 PGR ESR1
33 mucocele of appendix 10.3 PGR CEACAM5
34 breast adenoma 10.3 PGR ESR1
35 lipid-rich carcinoma 10.3 PGR ESR1
36 ovarian mucinous cystadenocarcinoma 10.3 SERPINA3 CEACAM5
37 xanthogranulomatous cholecystitis 10.3 SERPINA3 CEACAM5
38 prostate stromal sarcoma 10.3 PGR ESR1
39 chondroid chordoma 10.3 SERPINA3 CEACAM5
40 progesterone-receptor negative breast cancer 10.3 PGR ESR1
41 breast malignant phyllodes tumor 10.3 SERPINA3 PGR ESR1
42 leiomyosarcoma 10.3 SERPINA3 PGR ESR1
43 adenosarcoma 10.3 SERPINA3 PGR ESR1
44 prostatic hypertrophy 10.3 SERPINA3 PGR ESR1
45 verruciform xanthoma of skin 10.3 SERPINA3 CTSB
46 smooth muscle tumor 10.3 SERPINA3 PGR ESR1
47 sebaceous adenoma 10.3 SERPINA3 ESR1
48 breast fibroadenoma 10.3 SERPINA3 PGR ESR1
49 cervical clear cell adenocarcinoma 10.3 PGR NAPSA ESR1
50 teeth hard tissue disease 10.3 SERPINA3 PGR ESR1

Graphical network of the top 20 diseases related to Ovarian Endometrial Cancer:



Diseases related to Ovarian Endometrial Cancer

Symptoms & Phenotypes for Ovarian Endometrial Cancer

Drugs & Therapeutics for Ovarian Endometrial Cancer

Drugs for Ovarian Endometrial Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
2
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
3
Cysteine Approved, Nutraceutical Phase 2 52-90-4 5862
4 Protective Agents Phase 2
5 Respiratory System Agents Phase 2
6 Antioxidants Phase 2
7 Anti-Infective Agents Phase 2
8 Antiviral Agents Phase 2
9 topoisomerase I inhibitors Phase 2
10 N-monoacetylcystine Phase 2
11 Expectorants Phase 2
12 Antidotes Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Addition of N-Acetylcysteine to Topotecan in the Tumor Microenvironment of Persistent or Recurrent High Grade Endometrioid or Serous Ovarian Carcinoma Terminated NCT02569957 Phase 2 Topotecan Hydrochloride;Topotecan Hydrochloride;Acetylcysteine
2 Diagnosing Ovarian & Endometrial Cancer Early (DOvEE) by Targeting Symptomatic Women Recruiting NCT02296307

Search NIH Clinical Center for Ovarian Endometrial Cancer

Genetic Tests for Ovarian Endometrial Cancer

Anatomical Context for Ovarian Endometrial Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Ovarian Endometrial Cancer:

19
Ovary

MalaCards organs/tissues related to Ovarian Endometrial Cancer:

40
Ovary

Publications for Ovarian Endometrial Cancer

Articles related to Ovarian Endometrial Cancer:

# Title Authors PMID Year
1
Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women's Health Initiative Observational Study. 61
31542834 2019
2
Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study. 61
29235567 2018
3
Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer. 61
27838886 2017
4
Clear cell carcinoma of ovary with squamous metaplasia: A unique histopathological observation. 61
22557790 2011
5
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer. 61
18794095 2008
6
Aromatase inhibitors: possible future applications. 61
15255840 2004

Variations for Ovarian Endometrial Cancer

Expression for Ovarian Endometrial Cancer

Search GEO for disease gene expression data for Ovarian Endometrial Cancer.

Pathways for Ovarian Endometrial Cancer

Pathways related to Ovarian Endometrial Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 CTSB ADRB3 ADRB2

GO Terms for Ovarian Endometrial Cancer

Biological processes related to Ovarian Endometrial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mammary gland alveolus development GO:0060749 9.37 TGFA ESR1
2 adrenergic receptor signaling pathway GO:0071875 9.32 ADRB3 ADRB2
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 PGR ESR1
4 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.16 ADRB3 ADRB2
5 acute-phase response GO:0006953 9.13 SERPINA3 SERPINA1 HP
6 desensitization of G protein-coupled receptor signaling pathway by arrestin GO:0002032 8.62 ADRB3 ADRB2

Molecular functions related to Ovarian Endometrial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase inhibitor activity GO:0004867 9.33 SERPINB11 SERPINA3 SERPINA1
2 adrenergic receptor activity GO:0004935 8.96 ADRB3 ADRB2
3 norepinephrine binding GO:0051380 8.62 ADRB3 ADRB2

Sources for Ovarian Endometrial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....