MCID: OVR097
MIFTS: 33

Ovarian Fibrothecoma

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Fibrothecoma

MalaCards integrated aliases for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 59
Ovarian Thecoma 73

Characteristics:

Orphanet epidemiological data:

59
ovarian fibrothecoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



Summaries for Ovarian Fibrothecoma

MalaCards based summary : Ovarian Fibrothecoma, also known as ovarian thecoma, is related to liposarcoma and mulibrey nanism. An important gene associated with Ovarian Fibrothecoma is DES (Desmin), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Striated Muscle Contraction. Affiliated tissues include ovary, kidney and liver, and related phenotypes are ascites and abdominal pain

Related Diseases for Ovarian Fibrothecoma

Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 10.1 CALB2 DES
2 mulibrey nanism 10.0
3 sarcoma 10.0
4 retroperitoneal sarcoma 10.0
5 amenorrhea 10.0
6 leiomyomatosis 10.0
7 infertility 10.0
8 fibroblastic rheumatism 10.0 ACTC1 DES
9 angiolipoma 10.0 ACTC1 DES
10 cutaneous leiomyosarcoma 10.0 ACTC1 DES
11 botryoid rhabdomyosarcoma 10.0 ACTC1 DES
12 rhabdomyosarcoma 10.0 ACTC1 DES
13 spindle cell lipoma 10.0 ACTC1 DES
14 glomangioma 10.0 ACTC1 DES
15 parachordoma 10.0 ACTC1 DES
16 ossifying fibromyxoid tumor 10.0 ACTC1 DES
17 epithelioid leiomyosarcoma 10.0 ACTC1 DES
18 benign metastasizing leiomyoma 10.0 ACTC1 DES
19 adenofibroma 10.0 ACTC1 CALB2
20 non-langerhans-cell histiocytosis 10.0 ACTC1 DES
21 cutaneous fibrous histiocytoma 10.0 ACTC1 DES
22 fibrous histiocytoma 10.0 ACTC1 DES
23 congenital fibrosarcoma 10.0 ACTC1 DES
24 ischemic fasciitis 10.0 ACTC1 DES
25 fasciitis 10.0 ACTC1 DES
26 reticulum cell sarcoma 10.0 ACTC1 DES
27 pseudosarcomatous fibromatosis 10.0 ACTC1 DES
28 dedifferentiated liposarcoma 10.0 ACTC1 DES
29 glomus tumor 10.0 ACTC1 DES
30 spindle cell sarcoma 10.0 ACTC1 DES
31 horseshoe kidney 10.0 ACTC1 CALB2
32 hemangiopericytoma, malignant 10.0 ACTC1 DES
33 infantile myofibromatosis 10.0 ACTC1 DES
34 malignant fibroxanthoma 10.0 ACTC1 DES
35 chondromyxoid fibroma 10.0 ACTC1 DES
36 rhabdoid tumor predisposition syndrome 1 10.0 ACTC1 DES
37 spindle cell carcinoma 10.0 ACTC1 DES
38 gallbladder sarcoma 10.0 DES KIT
39 familial isolated dilated cardiomyopathy 10.0 ACTC1 DES
40 ovarian melanoma 10.0 CALB2 KIT
41 malignant leydig cell tumor 10.0 CALB2 KIT
42 peritoneal benign neoplasm 10.0 CALB2 KIT
43 diffuse peritoneal leiomyomatosis 10.0 CALB2 KIT
44 rete testis adenocarcinoma 10.0 CALB2 KIT
45 cystic nephroma 10.0 DES KIT
46 mixed germ cell-sex cord neoplasm 10.0 CALB2 KIT
47 polycystic liver disease 1 with or without kidney cysts 10.0 ACTC1 CALB2
48 spindle cell liposarcoma 10.0 CALB2 KIT
49 neurogenic bowel 9.9 CALB2 KIT
50 adenosarcoma 9.9 DES KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to Ovarian Fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

Human phenotypes related to Ovarian Fibrothecoma:

59 32 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ascites 59 32 frequent (33%) Frequent (79-30%) HP:0001541
2 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
3 abdominal distention 59 32 hallmark (90%) Very frequent (99-80%) HP:0003270
4 peritonitis 59 32 frequent (33%) Frequent (79-30%) HP:0002586
5 metrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100608
6 increased serum testosterone level 59 32 occasional (7.5%) Occasional (29-5%) HP:0030088
7 pleural effusion 59 32 hallmark (90%) Very frequent (99-80%) HP:0002202
8 diffuse leiomyomatosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0006756
9 hirsutism 59 32 occasional (7.5%) Occasional (29-5%) HP:0001007
10 gonadal calcification 59 32 occasional (7.5%) Occasional (29-5%) HP:0008703
11 ovarian fibroma 59 32 hallmark (90%) Very frequent (99-80%) HP:0010618
12 abnormality of the endometrium 59 32 occasional (7.5%) Occasional (29-5%) HP:0030126
13 fibrosarcoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0100244
14 abnormality of the ovary 59 Very frequent (99-80%)
15 abnormality of circulating hormone level 59 Occasional (29-5%)

Drugs & Therapeutics for Ovarian Fibrothecoma

Search Clinical Trials , NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

Anatomical Context for Ovarian Fibrothecoma

MalaCards organs/tissues related to Ovarian Fibrothecoma:

41
Ovary, Kidney, Liver, Colon, Testis, Smooth Muscle, Thymus

Publications for Ovarian Fibrothecoma

Articles related to Ovarian Fibrothecoma:

(show all 46)
# Title Authors Year
1
Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma. ( 28693292 )
2017
2
FDG-PET-positive ovarian thecoma with GLUT5 expression: Five cases. ( 27987341 )
2017
3
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. ( 27689825 )
2016
4
Ovarian thecoma with massive pleural effusion in postmenopausal women: A case report. ( 27284435 )
2016
5
Imaging Findings of Ovarian Fibrothecoma. ( 26564451 )
2015
6
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. ( 25635214 )
2014
7
Unilateral ovarian fibrothecoma with menorrhagia. ( 24763236 )
2014
8
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. ( 25556284 )
2014
9
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. ( 23431489 )
2013
10
Imaging features and pathologic characteristics of ovarian thecoma. ( 22261769 )
2012
11
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. ( 22096681 )
2011
12
Ovarian thecoma mimicking carcinoma on F-18 FDG PET in a postmenopausal woman with elevated CA-125. ( 22064092 )
2011
13
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. ( 18813938 )
2009
14
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. ( 19675518 )
2009
15
Ovarian thecoma with virilizing manifestations. ( 19259367 )
2009
16
Lipoma of the uterine corpus: exceptional eventuality combined with an ovarian thecoma. ( 19718431 )
2009
17
Luteinized ovarian thecoma in a postmenopausal women presenting with virilization. ( 19946643 )
2009
18
Ovarian thecoma: clinicopathological analysis of 50 cases. ( 18164409 )
2008
19
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. ( 16965622 )
2006
20
Ovarian thecoma with androgenic manifestations in a postmenopausal woman. ( 16864153 )
2006
21
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. ( 17415856 )
2004
22
Ovarian thecoma associated in the first trimester of pregnancy. ( 15327450 )
2004
23
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. ( 14617484 )
2003
24
Polypoid endometrial adenomyoma in a postmenopausal woman, mimicking cervical cancer, associated with ovarian thecoma. ( 12439557 )
2002
25
Ovarian thecoma associated with a large quantity of ascites and elevated serum CA 125 and CA 15-3. ( 12464996 )
2002
26
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. ( 11426907 )
2001
27
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. ( 10685524 )
2000
28
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. ( 10836709 )
2000
29
Ovarian fibrothecoma with massive edema. ( 11019495 )
2000
30
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. ( 7656212 )
1995
31
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. ( 7999713 )
1994
32
An ovarian thecoma with a single numerical aberration: +12. ( 8281525 )
1993
33
Transvaginal color Doppler sonography and CA-125 elevation in a patient with ovarian thecoma and ascites. ( 1321779 )
1992
34
Ovarian fibrothecoma: sonographic and histologic findings. ( 1662660 )
1991
35
Peritoneal tuberculosis, large ovarian thecoma, and an elevated serum CA 125 level mimicking ovarian cancer. ( 2551992 )
1989
36
Meigs's syndrome and ovarian thecoma in pregnancy. A case report. ( 3009804 )
1986
37
Sonographic appearance of the ovarian thecoma. ( 2988339 )
1985
38
Breast carcinoma metastasized in ovarian thecoma (a case report). ( 2992986 )
1985
39
Inflammatory fibroid polyp of the cecum, associated with adenomatous polyp and ovarian thecoma. ( 2995276 )
1985
40
Plasma hormone levels and oestrogen production in a postmenopausal woman with endometrial carcinoma and an ovarian thecoma. ( 226291 )
1979
41
Cytomegalovirus infection of ovarian thecoma. ( 228631 )
1979
42
Schistosomiasis of ovarian thecoma--a case report. ( 232801 )
1978
43
Cytologic changes in an ovarian thecoma. ( 180735 )
1976
44
Intrauterine contraceptive device and ovarian thecoma. ( 4287670 )
1966
45
ISOSEXUAL PRECOCITY PRODUCED BY AN OVARIAN THECOMA. REPORT OF A CASE. ( 14043274 )
1963
46
Ovarian thecoma; case reports with contrasting symptomatology. ( 18883217 )
1948

Variations for Ovarian Fibrothecoma

Expression for Ovarian Fibrothecoma

Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for Ovarian Fibrothecoma

Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 ACTC1 DES
2 10.81 ACTC1 DES
3 10.35 ACTC1 KIT

GO Terms for Ovarian Fibrothecoma

Cellular components related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 DES KIT

Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Ovarian Fibrothecoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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