MCID: OVR097
MIFTS: 30

Ovarian Fibrothecoma

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Ovarian Fibrothecoma

MalaCards integrated aliases for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 59
Ovarian Thecoma 73

Characteristics:

Orphanet epidemiological data:

59
ovarian fibrothecoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



Summaries for Ovarian Fibrothecoma

MalaCards based summary : Ovarian Fibrothecoma, also known as ovarian thecoma, is related to adenofibroma and horseshoe kidney. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Striated Muscle Contraction. Affiliated tissues include ovary, and related phenotypes are hirsutism and ascites

Related Diseases for Ovarian Fibrothecoma

Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 adenofibroma 10.2 ACTC1 CALB2
2 horseshoe kidney 10.2 ACTC1 CALB2
3 fibroblastic rheumatism 10.1 ACTC1 DES
4 angiolipoma 10.1 ACTC1 DES
5 cutaneous leiomyosarcoma 10.1 ACTC1 DES
6 botryoid rhabdomyosarcoma 10.1 ACTC1 DES
7 spindle cell lipoma 10.1 ACTC1 DES
8 lymphedema, hereditary, ii 10.1
9 parachordoma 10.1 ACTC1 DES
10 ossifying fibromyxoid tumor 10.1 ACTC1 DES
11 epithelioid leiomyosarcoma 10.1 ACTC1 DES
12 syringocystadenoma papilliferum 10.1 ACTC1 DES
13 benign metastasizing leiomyoma 10.1 ACTC1 DES
14 congenital fibrosarcoma 10.1 ACTC1 DES
15 pleomorphic liposarcoma 10.1 ACTC1 DES
16 ischemic fasciitis 10.1 ACTC1 DES
17 reticulum cell sarcoma 10.1 ACTC1 DES
18 dedifferentiated liposarcoma 10.1 ACTC1 DES
19 cutaneous fibrous histiocytoma 10.1 ACTC1 DES
20 glomus tumor 10.1 ACTC1 DES
21 spindle cell sarcoma 10.1 ACTC1 DES
22 non-langerhans-cell histiocytosis 10.1 ACTC1 DES
23 pseudosarcomatous fibromatosis 10.1 ACTC1 DES
24 rhabdoid cancer 10.1 ACTC1 DES
25 hemangiopericytoma, malignant 10.0 ACTC1 DES
26 infantile myofibromatosis 10.0 ACTC1 DES
27 chondromyxoid fibroma 10.0 ACTC1 DES
28 malignant fibroxanthoma 10.0 ACTC1 DES
29 fasciitis 10.0 ACTC1 DES
30 polycystic liver disease 1 with or without kidney cysts 10.0 ACTC1 CALB2
31 glomangioma 10.0 ACTC1 DES
32 spindle cell carcinoma 9.9 ACTC1 DES
33 familial isolated dilated cardiomyopathy 9.9 ACTC1 DES
34 mulibrey nanism 9.9
35 sarcoma 9.9
36 retroperitoneal sarcoma 9.9
37 amenorrhea 9.9
38 leiomyomatosis 9.9
39 infertility 9.9
40 ovarian melanoma 9.9 CALB2 KIT
41 atypical teratoid rhabdoid tumor 9.9 ACTC1 DES
42 malignant leydig cell tumor 9.9 CALB2 KIT
43 rete testis adenocarcinoma 9.9 CALB2 KIT
44 spindle cell liposarcoma 9.9 CALB2 KIT
45 neurogenic bowel 9.9 CALB2 KIT
46 rete testis neoplasm 9.8 CALB2 KIT
47 fibrous histiocytoma 9.8 ACTC1 DES
48 functional colonic disease 9.8 CALB2 KIT
49 necrotizing sialometaplasia 9.8 ACTC1 KIT
50 dysgerminoma of ovary 9.8 CALB2 KIT

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to Ovarian Fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

Human phenotypes related to Ovarian Fibrothecoma:

59 32 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hirsutism 59 32 occasional (7.5%) Occasional (29-5%) HP:0001007
2 ascites 59 32 frequent (33%) Frequent (79-30%) HP:0001541
3 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
4 pleural effusion 59 32 hallmark (90%) Very frequent (99-80%) HP:0002202
5 peritonitis 59 32 frequent (33%) Frequent (79-30%) HP:0002586
6 abdominal distention 59 32 hallmark (90%) Very frequent (99-80%) HP:0003270
7 diffuse leiomyomatosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0006756
8 gonadal calcification 59 32 occasional (7.5%) Occasional (29-5%) HP:0008703
9 ovarian fibroma 59 32 hallmark (90%) Very frequent (99-80%) HP:0010618
10 increased serum testosterone level 59 32 occasional (7.5%) Occasional (29-5%) HP:0030088
11 abnormality of the endometrium 59 32 occasional (7.5%) Occasional (29-5%) HP:0030126
12 fibrosarcoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0100244
13 metrorrhagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0100608
14 abnormality of the ovary 59 Very frequent (99-80%)
15 abnormality of circulating hormone level 59 Occasional (29-5%)

Drugs & Therapeutics for Ovarian Fibrothecoma

Search Clinical Trials , NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

Anatomical Context for Ovarian Fibrothecoma

MalaCards organs/tissues related to Ovarian Fibrothecoma:

41
Ovary

Publications for Ovarian Fibrothecoma

Articles related to Ovarian Fibrothecoma:

(show all 21)
# Title Authors Year
1
Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma. ( 28693292 )
2017
2
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. ( 27689825 )
2016
3
Imaging Findings of Ovarian Fibrothecoma. ( 26564451 )
2015
4
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. ( 25635214 )
2014
5
Unilateral ovarian fibrothecoma with menorrhagia. ( 24763236 )
2014
6
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. ( 25556284 )
2014
7
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. ( 23431489 )
2013
8
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. ( 22096681 )
2011
9
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas. ( 19329943 )
2009
10
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. ( 18813938 )
2009
11
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. ( 19675518 )
2009
12
Immunohistochemical localization patterns for vimentin and other intermediate filaments in calcified ovarian fibrothecoma. ( 16965622 )
2006
13
Ovarian fibrothecoma associated with Meigs' syndrome and elevated serum CA 125. ( 17415856 )
2004
14
Ovarian fibrothecoma: a benign neoplasm with potential adverse consequences. ( 14617484 )
2003
15
Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. ( 11426907 )
2001
16
Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. ( 10685524 )
2000
17
Tc-99m dicarboxypropane diphosphonate uptake in ovarian fibrothecoma. ( 10836709 )
2000
18
Ovarian fibrothecoma with massive edema. ( 11019495 )
2000
19
Numerical and structural chromosome abnormalities in an ovarian fibrothecoma. ( 7656212 )
1995
20
Refractory gestational hypertension due to a renin-secreting ovarian fibrothecoma associated with Gorlin's syndrome. ( 7999713 )
1994
21
Ovarian fibrothecoma: sonographic and histologic findings. ( 1662660 )
1991

Variations for Ovarian Fibrothecoma

Expression for Ovarian Fibrothecoma

Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for Ovarian Fibrothecoma

Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.39 ACTC1 DES
2 10.81 ACTC1 DES
3 10.35 ACTC1 KIT

GO Terms for Ovarian Fibrothecoma

Cellular components related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 DES KIT

Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Ovarian Fibrothecoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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