MCID: OVR097
MIFTS: 28

Ovarian Fibrothecoma

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Fibrothecoma

MalaCards integrated aliases for Ovarian Fibrothecoma:

Name: Ovarian Fibrothecoma 58
Ovarian Thecoma 70

Characteristics:

Orphanet epidemiological data:

58
ovarian fibrothecoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 D27
Orphanet 58 ORPHA314478
UMLS 70 C1882229

Summaries for Ovarian Fibrothecoma

MalaCards based summary : Ovarian Fibrothecoma, also known as ovarian thecoma, is related to leiomyomatosis and spindle cell sarcoma. An important gene associated with Ovarian Fibrothecoma is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Dilated cardiomyopathy and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary and pituitary, and related phenotypes are abdominal pain and pleural effusion

Related Diseases for Ovarian Fibrothecoma

Diseases related to Ovarian Fibrothecoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 leiomyomatosis 29.8 KIT CALB2
2 spindle cell sarcoma 29.4 KIT DES ACTC1
3 leiomyoma 29.4 KIT DES ACTC1
4 fibroma 29.3 DES CALB2 ACTC1
5 polymorphous low-grade adenocarcinoma 10.0 KIT ACTC1
6 juvenile nasopharyngeal angiofibroma 10.0 KIT ACTC1
7 chondroma 10.0 KIT ACTC1
8 perineurioma 10.0 KIT ACTC1
9 thymoma 10.0 KIT CALB2
10 benign fibrous mesothelioma 10.0 KIT CALB2
11 liver fibroma 10.0 KIT CALB2
12 mucinous stomach adenocarcinoma 10.0 KIT CALB2
13 ovarian gonadoblastoma 10.0 KIT CALB2
14 epithelioid hemangioendothelioma 10.0 CALB2 ACTC1
15 thymus clear cell carcinoma 10.0 KIT CALB2
16 liver leiomyosarcoma 10.0 KIT CALB2
17 lung leiomyosarcoma 10.0 KIT CALB2
18 bladder leiomyoma 10.0 KIT CALB2
19 heart cancer 10.0 KIT CALB2
20 ovarian cancer 10.0
21 ocular motor apraxia 10.0
22 sarcoma 10.0
23 hyperandrogenism 10.0
24 retroperitoneal sarcoma 10.0
25 amenorrhea 10.0
26 infertility 10.0
27 intravenous leiomyomatosis 10.0
28 lupus erythematosus 10.0
29 placental abruption 10.0
30 ovarian germ cell cancer 10.0 KIT CALB2
31 desmoid tumor 10.0 KIT ACTC1
32 seminal vesicle adenocarcinoma 10.0 KIT CALB2
33 adenofibroma 10.0 CALB2 ACTC1
34 hemangioma 10.0 KIT ACTC1
35 horseshoe kidney 10.0 CALB2 ACTC1
36 pleomorphic carcinoma 10.0 KIT CALB2
37 polycystic liver disease 1 with or without kidney cysts 10.0 CALB2 ACTC1
38 pericardium disease 10.0 KIT CALB2
39 mixed cell type cancer 10.0 KIT CALB2
40 cystic teratoma 9.9 KIT CALB2
41 connective tissue benign neoplasm 9.9 KIT CALB2
42 synovium cancer 9.9 KIT CALB2
43 neurofibroma 9.9 KIT ACTC1
44 thymic carcinoma 9.9 KIT CALB2
45 fibromatosis 9.9 DES ACTC1
46 fibroblastic rheumatism 9.9 DES ACTC1
47 benign metastasizing leiomyoma 9.9 DES ACTC1
48 cutaneous leiomyosarcoma 9.9 DES ACTC1
49 botryoid rhabdomyosarcoma 9.9 DES ACTC1
50 parachordoma 9.9 DES ACTC1

Graphical network of the top 20 diseases related to Ovarian Fibrothecoma:



Diseases related to Ovarian Fibrothecoma

Symptoms & Phenotypes for Ovarian Fibrothecoma

Human phenotypes related to Ovarian Fibrothecoma:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002027
2 pleural effusion 58 31 hallmark (90%) Very frequent (99-80%) HP:0002202
3 abdominal distention 58 31 hallmark (90%) Very frequent (99-80%) HP:0003270
4 ovarian fibroma 58 31 hallmark (90%) Very frequent (99-80%) HP:0010618
5 metrorrhagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0100608
6 ascites 58 31 frequent (33%) Frequent (79-30%) HP:0001541
7 peritonitis 58 31 frequent (33%) Frequent (79-30%) HP:0002586
8 hirsutism 58 31 occasional (7.5%) Occasional (29-5%) HP:0001007
9 fibrosarcoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0100244
10 increased serum testosterone level 58 31 occasional (7.5%) Occasional (29-5%) HP:0030088
11 gonadal calcification 58 31 occasional (7.5%) Occasional (29-5%) HP:0008703
12 diffuse leiomyomatosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0006756
13 abnormality of the endometrium 58 31 occasional (7.5%) Occasional (29-5%) HP:0030126
14 abnormality of the ovary 58 Very frequent (99-80%)
15 abnormality of circulating hormone level 58 Occasional (29-5%)

Drugs & Therapeutics for Ovarian Fibrothecoma

Search Clinical Trials , NIH Clinical Center for Ovarian Fibrothecoma

Genetic Tests for Ovarian Fibrothecoma

Anatomical Context for Ovarian Fibrothecoma

MalaCards organs/tissues related to Ovarian Fibrothecoma:

40
Ovary, Pituitary

Publications for Ovarian Fibrothecoma

Articles related to Ovarian Fibrothecoma:

(show top 50) (show all 130)
# Title Authors PMID Year
1
Clinical laboratory features of Meigs' syndrome: a retrospective study from 2009 to 2018. 61
32651935 2021
2
A rare case of recurrences of multiple ovarian fibrothecoma. 61
31825295 2021
3
Triple negative lobular breast carcinoma metastatic to an ovarian fibrothecoma. 61
32508260 2020
4
Benign ovarian thecoma with markedly elevated serum inhibin B levels mimicking adult granulosa cell tumor. 61
33204793 2020
5
MALDI-MSI-A Step Forward in Overcoming the Diagnostic Challenges in Ovarian Tumors. 61
33080944 2020
6
[Magnetic Resonance Imaging Features of Ovarian Thecoma]. 61
33131521 2020
7
Adolescent ovarian thecoma presenting as progressive hyperandrogenism: case report and review of the literature. 61
32174224 2020
8
Incidental ureteral fibroepithelial polyp. 61
33100571 2020
9
Analysis of magnetic resonance imaging features of ovarian thecoma. 61
32481327 2020
10
A presentation of ovarian fibrothecoma in a middle-aged female with recurrent massive ascites and postmenopausal bleeding: A case report. 61
33425356 2020
11
Ovarian fibrothecoma mimicking ovarian cancer: Using laparoscopy to avoid unnecessary exploratory laparotomy. 61
31759556 2019
12
Incidental Detection of Ovarian Thecoma by 99mTc-MDP Whole-Body Bone Scan: Contribution of Hybrid SPECT/CT. 61
31246684 2019
13
Ovarian Fibrothecoma. 61
31378246 2019
14
Female Progressive Scalp Hair Loss Associated with Ovarian Thecoma. 61
31367608 2019
15
Ovarian fibrothecoma in a young pregnant woman with lupus nephritis undergoing hemodialysis. 61
31251732 2019
16
A rare presentation of ovarian fibrothecoma in a middle age female: case report. 61
30881143 2019
17
Computed tomography and magnetic resonance imaging features of ovarian fibrothecoma. 61
28693292 2017
18
FDG-PET-positive ovarian thecoma with GLUT5 expression: Five cases. 61
27987341 2017
19
High cellularity and mitotic activity in a primary ovarian fibro-thecomatous tumor of a young patient: a diagnostic and clinical challenge. 61
29953799 2017
20
Ovarian thecoma-fibroma groups: clinical and sonographic features with pathological comparison. 61
27876070 2016
21
Inhibin A and inhibin B producing ovarian fibrothecoma revealed by suppression of follicle stimulating hormone (FSH) in a post-menopausal woman: report of the first case. 61
27689825 2016
22
New sonographic morphology score for the differentiation of malignant from benign ovarian tumors. 61
27125323 2016
23
Ovarian thecoma with massive pleural effusion in postmenopausal women: A case report. 61
27284435 2016
24
[Imaging Findings of Ovarian Fibrothecoma]. 61
26564451 2015
25
Meigs' syndrome with elevated CA-125 and HE-4: a case of luteinized fibrothecoma. 61
26327905 2015
26
Postmenopausal Meigs' Syndrome in Elevated CA-125: A Case Report. 61
26046039 2015
27
CT diagnosis in the thecoma-fibroma group of the ovarian stromal tumors. 61
25315640 2015
28
Susceptibility-weighted Imaging of Ovarian Torsion: A Case Report. 61
25740239 2015
29
Virilizing ovarian fibrothecoma with minor sex cord elements in a 13 year old girl: a rare case. 61
25635214 2014
30
Unilateral ovarian fibrothecoma with menorrhagia. 61
24763236 2014
31
Symptomatic Cushing syndrome and hyperandrogenemia revealing steroid cell ovarian neoplasm with late intra-abdominal metastasis. 61
24506845 2014
32
Meigs' syndrome with elevated serum CA 125 level in a case of ovarian fibrothecoma. 61
25556284 2014
33
Bilateral thecoma presenting as premenopausal hirsutism: Laproscopic removal. 61
24910832 2013
34
Meigs' syndrome: a rare cause of recurrent pleural effusion in scleroderma. 61
22538500 2013
35
Value of 3.0 T diffusion-weighted imaging in discriminating thecoma and fibrothecoma from other adnexal solid masses. 61
23962187 2013
36
Bilateral Ovarian Fibrothecoma Associated with Ascites, Bilateral Pleural Effusion, and Marked Elevated Serum CA-125. 61
23431489 2013
37
[Rare ovarian tumor]. 61
23427643 2012
38
Imaging features and pathologic characteristics of ovarian thecoma. 61
22261769 2012
39
Ovarian thecoma mimicking carcinoma on F-18 FDG PET in a postmenopausal woman with elevated CA-125. 61
22064092 2011
40
[Demons-Meigs syndrome: information on a new case and review of the literature]. 61
21497729 2011
41
Bilateral ovarian fibrothecoma. An uncommon cause of a large pelvic mass. 61
22096681 2011
42
Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH. 61
20334861 2010
43
Testicular thecoma in an 11-year-old boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome). 61
20223301 2010
44
Virilizing luteinized thecoma of the ovary in a 15-year-old female: a case report. 61
19576809 2009
45
Computed tomography appearance of ovarian fibrothecomas with and without torsion. 61
19455450 2009
46
Giant malignant ovarian fibrothecoma involved with retroperitoneal structures mimicking a retroperitoneal sarcoma. 61
18813938 2009
47
Ovarian stromal hyperthecosis: sonographic features and histologic associations. 61
19389897 2009
48
Ovarian thecoma with virilizing manifestations. 61
19259367 2009
49
Meigs' syndrome and virilizing ovarian fibrothecoma complicating pregnancy. A case report and review of the literature. 61
19675518 2009
50
Lipoma of the uterine corpus: exceptional eventuality combined with an ovarian thecoma. 61
19718431 2009

Variations for Ovarian Fibrothecoma

Expression for Ovarian Fibrothecoma

Search GEO for disease gene expression data for Ovarian Fibrothecoma.

Pathways for Ovarian Fibrothecoma

Pathways related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.53 DES ACTC1
2 11.13 KIT DES
3 10.81 DES ACTC1
4 10.35 KIT ACTC1

GO Terms for Ovarian Fibrothecoma

Biological processes related to Ovarian Fibrothecoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 DES ACTC1

Sources for Ovarian Fibrothecoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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