MCID: OVR112
MIFTS: 42

Ovarian Germ Cell Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Cancer

MalaCards integrated aliases for Ovarian Germ Cell Cancer:

Name: Ovarian Germ Cell Cancer 58 12 15
Ovarian Germ Cell Tumor 12 54 56 17 74
Malignant Ovarian Germ Cell Neoplasm 74
Germ Cell Neoplasm of Ovary 12
Germ Cell Tumor of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2156
OMIM 58 603737
NCIt 51 C3873
MedGen 43 C0346180

Summaries for Ovarian Germ Cell Cancer

OMIM : 58 Ovarian germ cell cancers are malignancies that arise from germ cells of the embryonic gonad. Although benign germ cell tumors are relatively common, accounting for approximately 20% of all ovarian neoplasms, malignant ovarian germ cell tumors are rare. Weiss et al. (1977) estimated that less than 5% of ovarian cancers are of germ cell origin. (603737)

MalaCards based summary : Ovarian Germ Cell Cancer, also known as ovarian germ cell tumor, is related to endodermal sinus tumor and teratoma. An important gene associated with Ovarian Germ Cell Cancer is TG (Thyroglobulin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Carboplatin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An ovarian cancer that originates in the germ (egg) cells of the ovary.

Related Diseases for Ovarian Germ Cell Cancer

Diseases related to Ovarian Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 30.4 AFP SALL4
2 teratoma 29.7 AFP KRT7 NKX2-1 SYP
3 malignant non-dysgerminomatous germ cell tumor of ovary 12.4
4 ovarian mixed germ cell neoplasm 11.7
5 pediatric ovarian germ cell tumor 11.3
6 germ cell cancer 10.3
7 struma ovarii 10.3 NKX2-1 TG
8 mature teratoma 10.3 AFP TG
9 germ cells tumors 10.3
10 colloid adenoma 10.3 NKX2-1 TG
11 athyreosis 10.3 NKX2-1 TG
12 follicular adenoma 10.3 NKX2-1 TG
13 hypothyroidism, congenital, nongoitrous, 2 10.2 NKX2-1 TG
14 fetal adenoma 10.2 NKX2-1 TG
15 growing teratoma syndrome 10.2
16 rete testis adenocarcinoma 10.2 AFP NKX2-1
17 intrahepatic bile duct adenoma 10.2 AFP KRT7
18 papillary thyroid microcarcinoma 10.2 NKX2-1 TG
19 renal pelvis adenocarcinoma 10.2 AFP KRT7
20 rete testis neoplasm 10.2 AFP NKX2-1
21 intratubular embryonal carcinoma 10.2 AFP KRT7
22 bile duct cystadenocarcinoma 10.2 AFP KRT7
23 choriocarcinoma of the testis 10.2 AFP KRT7
24 adenomatoid tumor 10.2 AFP KRT7
25 solid adenocarcinoma with mucin production 10.2 KRT7 NKX2-1
26 lung acinar adenocarcinoma 10.2 KRT7 NKX2-1
27 breast secretory carcinoma 10.2 KRT7 TG
28 papillary adenoma 10.2 KRT7 NKX2-1
29 multinodular goiter 10.2 NKX2-1 TG
30 pseudo-meigs syndrome 10.2
31 papillary serous adenocarcinoma 10.2 KRT7 NKX2-1
32 intestinal perforation 10.2 KRT7 NKX2-1
33 goiter 10.2 NKX2-1 TG
34 sertoli-leydig cell tumor 10.2 AFP KRT7
35 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT7 NKX2-1
36 pleomorphic carcinoma 10.1 KRT7 NKX2-1
37 alveoli adenoma 10.1 KRT7 NKX2-1
38 acinar cell carcinoma 10.1 AFP KRT7
39 embryoma 10.1 AFP SALL4
40 germ cell and embryonal cancer 10.1 AFP KRT7
41 bile duct adenocarcinoma 10.1 AFP KRT7
42 mixed germ cell tumor 10.1
43 hidradenocarcinoma 10.1 KRT7 NKX2-1
44 thyroid gland disease 10.1 NKX2-1 TG
45 mucinous adenocarcinoma 10.1 KRT7 NKX2-1
46 papillary adenocarcinoma 10.1 KRT7 NKX2-1
47 extragonadal seminoma 10.1 AFP SALL4
48 bronchiolo-alveolar adenocarcinoma 10.1 KRT7 NKX2-1
49 dysgerminoma 10.1 AFP KRT7
50 teratocarcinoma 10.1

Graphical network of the top 20 diseases related to Ovarian Germ Cell Cancer:



Diseases related to Ovarian Germ Cell Cancer

Symptoms & Phenotypes for Ovarian Germ Cell Cancer

Clinical features from OMIM:

603737

GenomeRNAi Phenotypes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.28 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.28 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.28 KRT7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.28 AFP KRT7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.28 AFP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.28 AFP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.28 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.28 KRT7

MGI Mouse Phenotypes related to Ovarian Germ Cell Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 AFP HLX KRT7 NKX2-1 SALL4 TG

Drugs & Therapeutics for Ovarian Germ Cell Cancer

Drugs for Ovarian Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 308)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 1,Phase 2,Not Applicable 41575-94-4 10339178 38904 498142
2
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
3
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
4
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
5
Vinblastine Approved Phase 3 865-21-4 241903 13342
6
Cisplatin Approved Phase 3,Phase 1,Phase 2 15663-27-1 2767 441203 84093
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2,Not Applicable 33069-62-4 36314
8
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
9
Histamine Approved, Investigational Phase 3 51-45-6 774
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
13
Ofloxacin Approved Phase 3 82419-36-1 4583
14
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
15
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
16
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
17
Polyestradiol phosphate Approved Phase 3 28014-46-2
18
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
19
Captopril Approved Phase 3 62571-86-2 44093
20
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
21
Ribavirin Approved Phase 3 36791-04-5 37542
22
Palivizumab Approved, Investigational Phase 3 188039-54-5
23
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
24
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
25
Caspofungin Approved Phase 3,Phase 2 162808-62-0, 179463-17-3 2826718 468682
26
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
27
Acyclovir Approved Phase 3 59277-89-3 2022
28
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 3 53-43-0 9860744
29 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
30 Antimitotic Agents Phase 3,Phase 1,Phase 2,Not Applicable
31
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
32 Alkylating Agents Phase 3,Phase 1,Phase 2,Not Applicable
33 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
34 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2,Not Applicable
35 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
37 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
38 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2,Not Applicable
39 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2,Not Applicable
40 Liver Extracts Phase 3,Phase 1,Phase 2,Not Applicable
41 Protective Agents Phase 3,Phase 2,Phase 1,Not Applicable
42 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
43 Cola Phase 3,Phase 1,Phase 2,Not Applicable
44 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
45 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
46 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
47 Antiviral Agents Phase 3,Phase 1,Phase 2
48 Antimetabolites Phase 3,Phase 1,Phase 2
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormone Antagonists Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 183)
# Name Status NCT ID Phase Drugs
1 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
3 TC or BEP in Treating Patients With Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
4 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
5 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
6 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
7 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
8 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
9 Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms Completed NCT01376349 Phase 3 prasterone
10 A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families Completed NCT00782145 Phase 3
11 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
12 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
13 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
14 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
15 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
16 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
17 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
18 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
19 Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation Unknown status NCT00036712 Phase 2
20 Paclitaxel-Loaded Polymeric Micelle and Carboplatin as First-Line Therapy in Treating Patients With Advanced Ovarian Cancer Unknown status NCT00886717 Phase 1, Phase 2 carboplatin;paclitaxel-loaded polymeric micelle
21 Squalamine Lactate Plus Carboplatin in Treating Patients With Recurrent or Refractory Stage III or Stage IV Ovarian Cancer Unknown status NCT00021385 Phase 2 carboplatin;squalamine lactate
22 Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer Unknown status NCT02283658 Phase 2 Everolimus;Letrozole
23 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
24 Whole Body Hyperthermia Combined With Chemotherapy in Treating Patients With Metastatic Breast, Ovarian, Endometrial, or Cervical Cancer Unknown status NCT00003135 Phase 2 fluorouracil;pegylated liposomal doxorubicin hydrochloride
25 Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer Unknown status NCT00905658 Phase 2
26 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
27 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
28 Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
29 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
30 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
31 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
32 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
33 Combination Chemotherapy in Treating Patients With Germ Cell Tumors That Have Not Responded to Previous Cisplatin Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
34 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
35 Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
36 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
37 Paclitaxel Plus Gemcitabine in Treating Patients With Refractory Metastatic Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
38 Temozolomide in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to Cisplatin Completed NCT00006043 Phase 2 temozolomide
39 Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Ovarian Cancer Terminated NCT00003532 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
40 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
41 Doxorubicin and Carboplatin in Treating Patients With Recurrent Ovarian Cancer Withdrawn NCT00562185 Phase 1, Phase 2 carboplatin;doxorubicin hydrochloride
42 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
43 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Terminated NCT00003852 Phase 2 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;paclitaxel;thiotepa
44 Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02122185 Phase 2 metformin hydrochloride;placebo;Chemotherapy
45 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Completed NCT01764802 Phase 2
46 Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies Completed NCT01079832 Phase 2
47 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
48 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
49 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
50 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin

Search NIH Clinical Center for Ovarian Germ Cell Cancer

Genetic Tests for Ovarian Germ Cell Cancer

Anatomical Context for Ovarian Germ Cell Cancer

MalaCards organs/tissues related to Ovarian Germ Cell Cancer:

42
Ovary, Bone, Bone Marrow, Colon, T Cells, Thyroid, Testis

Publications for Ovarian Germ Cell Cancer

Articles related to Ovarian Germ Cell Cancer:

(show all 50)
# Title Authors Year
1
Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowth in a two-year-old female. ( 31038288 )
2019
2
Long-term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor. ( 30289161 )
2019
3
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. ( 30349318 )
2018
4
Paraneoplastic Cytopenia in Ovarian Germ Cell Tumor: A Novel Presentation. ( 29240033 )
2018
5
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. ( 30086295 )
2018
6
Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. ( 28202195 )
2017
7
Is Omentectomy Mandatory Among Early Stage (I, II) Malignant Ovarian Germ Cell Tumor Patients? A Retrospective Study of 223 Cases. ( 28520571 )
2017
8
High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report. ( 29062883 )
2017
9
Fertility-sparing surgery in advanced stage malignant ovarian germ cell tumor: a case report. ( 29248013 )
2017
10
Laparoscopic Treatment of Mixed Malignant Ovarian Germ Cell Tumor in a 16-Year-Old Female Adolescent. ( 27262834 )
2016
11
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". ( 25511159 )
2015
12
Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma. ( 25518772 )
2014
13
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis. ( 24836278 )
2014
14
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. ( 24681864 )
2014
15
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. ( 23148694 )
2013
16
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. ( 24222875 )
2013
17
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. ( 24376332 )
2013
18
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? ( 24475592 )
2013
19
Minilaparotomy a good option in specific cases: a case report of bilateral ovarian germ cell tumor. ( 22567526 )
2012
20
Uncommon vascular tumor of the ovary. Primary ovarian epithelioid hemangioendothelioma or vascular sarcomatous transformation in ovarian germ cell tumor? ( 21822906 )
2011
21
Malignant mixed ovarian germ cell tumor with embryonal component. ( 20869284 )
2011
22
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. ( 20168245 )
2010
23
Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. ( 19636015 )
2009
24
FDG uptake in parahepatic brown fat mimics peritoneal carcinomatosis in a malignant ovarian germ cell tumor: resolution with temperature control. ( 18936621 )
2008
25
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. ( 19042263 )
2008
26
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. ( 17413983 )
2007
27
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. ( 17602084 )
2007
28
Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. ( 17048439 )
2006
29
Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. ( 16578998 )
2006
30
Pseudo-Meigs syndrome secondary to ovarian germ cell tumor. ( 15852294 )
2005
31
Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. ( 16623016 )
2005
32
Trisomy 14pter --> q21: a case with associated ovarian germ cell tumor and review of the literature. ( 15211663 )
2004
33
Quality of life after among ovarian germ cell cancer survivors: a narrative analysis. ( 12719752 )
2003
34
[Treatment of malignant ovarian germ cell tumor and sex cord tumors]. ( 12214461 )
2002
35
Ovarian germ cell cancer: clinicopathologic analysis and outcome of 31 cases. ( 11218184 )
2000
36
Familial ovarian germ cell cancer: report and review. ( 10213045 )
1999
37
A case of pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. ( 9841228 )
1998
38
Cytogenetics of a malignant ovarian germ-cell tumor. ( 9650555 )
1998
39
Pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. ( 9299274 )
1997
40
Secondary ANLL with t(11;19)(q23;p13) following etoposide and cisplatin for ovarian germ cell tumor. ( 9491667 )
1997
41
Activity of gemcitabine in platinum-resistant ovarian germ cell cancer. ( 8869115 )
1996
42
Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). ( 8908168 )
1996
43
Ovarian germ cell tumor evolving to myelodysplasia. ( 7692949 )
1993
44
Radiological case of the month. Malignant ovarian germ cell tumor. ( 8395763 )
1993
45
Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. ( 2253191 )
1990
46
Hormonal factors and risk of ovarian germ cell cancer in young women. ( 3390378 )
1988
47
A canine ovarian germ cell tumor with extraembryonic differentiation. ( 3029938 )
1987
48
Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. ( 6203815 )
1984
49
Mixed ovarian germ cell tumor in 46,X, +mar Turner's syndrome: a case report. ( 6525086 )
1984
50
Malignant mixed ovarian germ cell tumor. ( 6283329 )
1982

Variations for Ovarian Germ Cell Cancer

ClinVar genetic disease variations for Ovarian Germ Cell Cancer:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CBL NM_005188.3(CBL): c.1228-2A> G single nucleotide variant Conflicting interpretations of pathogenicity rs727504426 GRCh38 Chromosome 11, 119278508: 119278508
2 CBL NM_005188.3(CBL): c.1228-2A> G single nucleotide variant Conflicting interpretations of pathogenicity rs727504426 GRCh37 Chromosome 11, 119149218: 119149218
3 FANCM NM_020937.3(FANCM): c.5791C> T (p.Arg1931Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs144567652 GRCh37 Chromosome 14, 45667921: 45667921
4 FANCM NM_020937.3(FANCM): c.5791C> T (p.Arg1931Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs144567652 GRCh38 Chromosome 14, 45198718: 45198718

Expression for Ovarian Germ Cell Cancer

Search GEO for disease gene expression data for Ovarian Germ Cell Cancer.

Pathways for Ovarian Germ Cell Cancer

Pathways related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 AFP NKX2-1

GO Terms for Ovarian Germ Cell Cancer

Biological processes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 8.62 NKX2-1 TG

Sources for Ovarian Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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