MCID: OVR112
MIFTS: 44

Ovarian Germ Cell Cancer

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Cancer

MalaCards integrated aliases for Ovarian Germ Cell Cancer:

Name: Ovarian Germ Cell Cancer 57 12 15
Ovarian Germ Cell Tumor 12 53 55 73
Malignant Ovarian Germ Cell Neoplasm 73
Germ Cell Neoplasm of Ovary 12
Germ Cell Tumor of Ovary 12

Classifications:



External Ids:

OMIM 57 603737
Disease Ontology 12 DOID:2156
NCIt 50 C3873
MedGen 42 C0346180

Summaries for Ovarian Germ Cell Cancer

OMIM : 57 Ovarian germ cell cancers are malignancies that arise from germ cells of the embryonic gonad. Although benign germ cell tumors are relatively common, accounting for approximately 20% of all ovarian neoplasms, malignant ovarian germ cell tumors are rare. Weiss et al. (1977) estimated that less than 5% of ovarian cancers are of germ cell origin. (603737)

MalaCards based summary : Ovarian Germ Cell Cancer, also known as ovarian germ cell tumor, is related to endodermal sinus tumor and teratoma. An important gene associated with Ovarian Germ Cell Cancer is TG (Thyroglobulin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Cisplatin and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An ovarian cancer that originates in the germ (egg) cells of the ovary.

Related Diseases for Ovarian Germ Cell Cancer

Diseases related to Ovarian Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 30.3 AFP SALL4
2 teratoma 30.2 AFP KRT7 NKX2-1
3 malignant non-dysgerminomatous germ cell tumor of ovary 12.4
4 ovarian mixed germ cell neoplasm 11.7
5 pediatric ovarian germ cell tumor 11.2
6 germ cell cancer 10.3
7 germ cells tumors 10.3
8 mature teratoma 10.2 AFP TG
9 colloid adenoma 10.2 NKX2-1 TG
10 growing teratoma syndrome 10.2
11 pseudo-meigs syndrome 10.2
12 athyreosis 10.2 NKX2-1 TG
13 hypothyroidism, congenital, nongoitrous, 2 10.2 NKX2-1 TG
14 fetal adenoma 10.1 NKX2-1 TG
15 rete testis adenocarcinoma 10.1 AFP NKX2-1
16 papillary thyroid microcarcinoma 10.1 NKX2-1 TG
17 benign struma ovarii 10.1 RET TG
18 rete testis neoplasm 10.1 AFP NKX2-1
19 goiter 10.1 NKX2-1 TG
20 malignant teratoma 10.1 AFP SALL4
21 mixed germ cell tumor 10.1
22 embryoma 10.1 AFP SALL4
23 nodular goiter 10.1 RET TG
24 extragonadal seminoma 10.1 AFP SALL4
25 multinodular goiter 10.1 NKX2-1 TG
26 teratocarcinoma 10.1
27 embryonal carcinoma 10.1
28 testicular yolk sac tumor 10.1 AFP SALL4
29 anaplastic thyroid cancer 10.1 NKX2-1 TG
30 thyroiditis 10.1 RET TG
31 intrahepatic bile duct adenoma 10.0 AFP KRT7
32 renal pelvis adenocarcinoma 10.0 AFP KRT7
33 intratubular embryonal carcinoma 10.0 AFP KRT7
34 bile duct cystadenocarcinoma 10.0 AFP KRT7
35 breast secretory carcinoma 10.0 KRT7 TG
36 seminal vesicle tumor 10.0 AFP KRT7
37 choriocarcinoma of the testis 10.0 AFP KRT7
38 cystic teratoma 10.0 KRT7 NKX2-1
39 solid adenocarcinoma with mucin production 10.0 KRT7 NKX2-1
40 lung acinar adenocarcinoma 10.0 KRT7 NKX2-1
41 small cell carcinoma of the bladder 10.0 KRT7 NKX2-1
42 small cell carcinoma 10.0 KRT7 NKX2-1
43 sertoli-leydig cell tumor 10.0 AFP KRT7
44 papillary adenoma 10.0 KRT7 NKX2-1
45 papillary serous adenocarcinoma 10.0 KRT7 NKX2-1
46 endocrine gland cancer 10.0 AFP RET TG
47 intestinal perforation 10.0 KRT7 NKX2-1
48 mixed cell type cancer 10.0 AFP KRT7
49 pulmonary sclerosing hemangioma 10.0 KRT7 NKX2-1
50 acinar cell carcinoma 10.0 AFP KRT7

Graphical network of the top 20 diseases related to Ovarian Germ Cell Cancer:



Diseases related to Ovarian Germ Cell Cancer

Symptoms & Phenotypes for Ovarian Germ Cell Cancer

Clinical features from OMIM:

603737

GenomeRNAi Phenotypes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.23 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.23 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.23 KRT7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.23 AFP KRT7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.23 AFP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.23 AFP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.23 KRT7

MGI Mouse Phenotypes related to Ovarian Germ Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 HLX NKX2-1 RET SALL4 TG
2 endocrine/exocrine gland MP:0005379 9.35 AFP HLX NKX2-1 RET TG
3 homeostasis/metabolism MP:0005376 9.17 AFP HLX KRT7 NKX2-1 RET SALL4

Drugs & Therapeutics for Ovarian Germ Cell Cancer

Drugs for Ovarian Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
2
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
3
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
4
Vinblastine Approved Phase 3 865-21-4 241903 13342
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
8
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
11 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
12 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
13 Alkylating Agents Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
15 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
16 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
17 Antimitotic Agents Phase 3,Phase 2,Phase 1
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
19 Liver Extracts Phase 3,Phase 1,Phase 2
20 Albumin-Bound Paclitaxel Phase 3,Phase 2
21 Serotonin Agents Phase 3
22 Anti-Allergic Agents Phase 3
23 Serotonin Antagonists Phase 3
24 Histamine H1 Antagonists Phase 3
25
Histamine Phosphate Phase 3 51-74-1 65513
26 Antipruritics Phase 3
27 Neurotransmitter Agents Phase 3
28 Dermatologic Agents Phase 3
29 Histamine Antagonists Phase 3
30 Gastrointestinal Agents Phase 3
31 sodium thiosulfate Phase 3
32 Anti-Infective Agents Phase 3
33 Antioxidants Phase 3
34 Antitubercular Agents Phase 3
35 Chelating Agents Phase 3
36 Antidotes Phase 3
37 Protective Agents Phase 3,Phase 2,Phase 1
38
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
39
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 6055-19-2, 50-18-0 2907
40
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
41
Mechlorethamine Approved, Investigational Phase 2,Phase 1 51-75-2 4033
42
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
43
Amifostine Approved, Investigational Phase 2,Phase 1 20537-88-6 2141
44
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
45
Mesna Approved, Investigational Phase 2 3375-50-6 598
46
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
47
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
48 Immunologic Factors Phase 2,Phase 1
49 Immunosuppressive Agents Phase 2,Phase 1
50 Adjuvants, Immunologic Phase 2,Phase 1

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 TC or BEP in Treating Patients With Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
3 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
6 Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation Unknown status NCT00036712 Phase 2
7 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
8 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
9 Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
10 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
11 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
12 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
13 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
14 Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors Unknown status NCT00007813 Phase 1 carboplatin;cyclophosphamide;etoposide
15 Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors Terminated NCT00003926 Phase 1 amifostine trihydrate;busulfan;filgrastim;melphalan;thiotepa
16 Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant Completed NCT00569283 Phase 1
17 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
18 Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors Completed NCT00303940 Phase 1 carboplatin;talabostat mesylate;temozolomide
19 ABT-751 in Treating Young Patients With Refractory Solid Tumors Completed NCT00036959 Phase 1 ABT-751
20 Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy Completed NCT00030108 Phase 1 ixabepilone
21 Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors Completed NCT00020150 Phase 1 O6-benzylguanine;temozolomide
22 Etoposide, Carboplatin, and Bleomycin in Treating Young Patients Undergoing Surgery For Malignant Germ Cell Tumors Unknown status NCT00276718 Not Applicable carboplatin;etoposide
23 Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01 Unknown status NCT00436774
24 Quality-of-Life Study of Patients With Previously Treated Ovarian Cancer Terminated NCT00003794
25 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
26 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
27 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
28 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
29 Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer Completed NCT00002485
30 Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma Completed NCT00040911 Not Applicable

Search NIH Clinical Center for Ovarian Germ Cell Cancer

Genetic Tests for Ovarian Germ Cell Cancer

Anatomical Context for Ovarian Germ Cell Cancer

MalaCards organs/tissues related to Ovarian Germ Cell Cancer:

41
Ovary, Bone, Bone Marrow, Brain, Lung, Liver, T Cells

Publications for Ovarian Germ Cell Cancer

Articles related to Ovarian Germ Cell Cancer:

(show all 49)
# Title Authors Year
1
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. ( 30349318 )
2018
2
Paraneoplastic Cytopenia in Ovarian Germ Cell Tumor: A Novel Presentation. ( 29240033 )
2018
3
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. ( 30086295 )
2018
4
Long-term neurotoxicity and raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor. ( 30289161 )
2018
5
Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. ( 28202195 )
2017
6
Is Omentectomy Mandatory Among Early Stage (I, II) Malignant Ovarian Germ Cell Tumor Patients? A Retrospective Study of 223 Cases. ( 28520571 )
2017
7
High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report. ( 29062883 )
2017
8
Fertility-sparing surgery in advanced stage malignant ovarian germ cell tumor: a case report. ( 29248013 )
2017
9
Laparoscopic Treatment of Mixed Malignant Ovarian Germ Cell Tumor in a 16-Year-Old Female Adolescent. ( 27262834 )
2016
10
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". ( 25511159 )
2015
11
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. ( 24681864 )
2014
12
Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma. ( 25518772 )
2014
13
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis. ( 24836278 )
2014
14
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. ( 24222875 )
2013
15
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. ( 24376332 )
2013
16
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. ( 23148694 )
2013
17
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? ( 24475592 )
2013
18
Minilaparotomy a good option in specific cases: a case report of bilateral ovarian germ cell tumor. ( 22567526 )
2012
19
Uncommon vascular tumor of the ovary. Primary ovarian epithelioid hemangioendothelioma or vascular sarcomatous transformation in ovarian germ cell tumor? ( 21822906 )
2011
20
Malignant mixed ovarian germ cell tumor with embryonal component. ( 20869284 )
2011
21
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. ( 20168245 )
2010
22
Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. ( 19636015 )
2009
23
FDG uptake in parahepatic brown fat mimics peritoneal carcinomatosis in a malignant ovarian germ cell tumor: resolution with temperature control. ( 18936621 )
2008
24
Case-control comparison of quality of life in long-term ovarian germ cell tumor survivors: a gynecologic oncology group study. ( 19042263 )
2008
25
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. ( 17602084 )
2007
26
Mixed ovarian germ cell tumor in a BRCA2 mutation carrier. ( 17413983 )
2007
27
Outcome of recurrent and persistent disease of malignant ovarian germ cell tumor: a retrospective analysis at King Chulalongkorn Memorial Hospital. ( 16578998 )
2006
28
Transient cortical blindness during chemotherapy (PVB) for ovarian germ cell tumor. ( 17048439 )
2006
29
Pseudo-Meigs syndrome secondary to ovarian germ cell tumor. ( 15852294 )
2005
30
Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. ( 16623016 )
2005
31
Trisomy 14pter --> q21: a case with associated ovarian germ cell tumor and review of the literature. ( 15211663 )
2004
32
Quality of life after among ovarian germ cell cancer survivors: a narrative analysis. ( 12719752 )
2003
33
[Treatment of malignant ovarian germ cell tumor and sex cord tumors]. ( 12214461 )
2002
34
Ovarian germ cell cancer: clinicopathologic analysis and outcome of 31 cases. ( 11218184 )
2000
35
Familial ovarian germ cell cancer: report and review. ( 10213045 )
1999
36
A case of pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. ( 9841228 )
1998
37
Cytogenetics of a malignant ovarian germ-cell tumor. ( 9650555 )
1998
38
Pseudo-Meigs' syndrome secondary to an ovarian germ cell tumor. ( 9299274 )
1997
39
Secondary ANLL with t(11;19)(q23;p13) following etoposide and cisplatin for ovarian germ cell tumor. ( 9491667 )
1997
40
Activity of gemcitabine in platinum-resistant ovarian germ cell cancer. ( 8869115 )
1996
41
Ovarian germ cell tumor with chromosome 12 anomaly but without i(12p). ( 8908168 )
1996
42
Radiological case of the month. Malignant ovarian germ cell tumor. ( 8395763 )
1993
43
Ovarian germ cell tumor evolving to myelodysplasia. ( 7692949 )
1993
44
Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. ( 2253191 )
1990
45
Hormonal factors and risk of ovarian germ cell cancer in young women. ( 3390378 )
1988
46
A canine ovarian germ cell tumor with extraembryonic differentiation. ( 3029938 )
1987
47
Secretion of human chorionic gonadotropin and alpha-fetoprotein by an ovarian germ cell tumor of apparent yolk sac origin. ( 6203815 )
1984
48
Mixed ovarian germ cell tumor in 46,X, +mar Turner's syndrome: a case report. ( 6525086 )
1984
49
Malignant mixed ovarian germ cell tumor. ( 6283329 )
1982

Variations for Ovarian Germ Cell Cancer

Expression for Ovarian Germ Cell Cancer

Search GEO for disease gene expression data for Ovarian Germ Cell Cancer.

Pathways for Ovarian Germ Cell Cancer

Pathways related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 AFP NKX2-1

GO Terms for Ovarian Germ Cell Cancer

Biological processes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 8.96 NKX2-1 TG
2 enteric nervous system development GO:0048484 8.62 HLX RET

Sources for Ovarian Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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