MOGCT
MCID: OVR112
MIFTS: 41

Ovarian Germ Cell Cancer (MOGCT)

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Cancer

MalaCards integrated aliases for Ovarian Germ Cell Cancer:

Name: Ovarian Germ Cell Cancer 57 12 58 15
Ovarian Germ Cell Tumor 12 20 54 17 70
Malignant Germ Cell Tumor of Ovary 58 6
Malignant Ovarian Germ Cell Neoplasm 70
Malignant Ovarian Germ Cell Tumor 58
Germ Cell Neoplasm of Ovary 12
Germ Cell Tumor of Ovary 12
Mogct 58

Characteristics:

Orphanet epidemiological data:

58
malignant germ cell tumor of ovary
Prevalence: <1/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (United States); Age of onset: Adolescent,Adult,Childhood,Elderly,Infancy; Age of death: any age;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:2156
OMIM® 57 603737
NCIt 50 C3873
SNOMED-CT 67 237059008
ICD10 via Orphanet 33 C56
UMLS via Orphanet 71 C0346180
Orphanet 58 ORPHA35807
MedGen 41 C0346180
UMLS 70 C0238324 C0346180

Summaries for Ovarian Germ Cell Cancer

OMIM® : 57 Ovarian germ cell cancers are malignancies that arise from germ cells of the embryonic gonad. Although benign germ cell tumors are relatively common, accounting for approximately 20% of all ovarian neoplasms, malignant ovarian germ cell tumors are rare. Weiss et al. (1977) estimated that less than 5% of ovarian cancers are of germ cell origin. (603737) (Updated 20-May-2021)

MalaCards based summary : Ovarian Germ Cell Cancer, also known as ovarian germ cell tumor, is related to ovarian mixed germ cell neoplasm and mixed germ cell tumor. An important gene associated with Ovarian Germ Cell Cancer is FANCM (FA Complementation Group M), and among its related pathways/superpathways is Regulation of KIT signaling. The drugs Cisplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and liver, and related phenotype is reproductive system.

Disease Ontology : 12 An ovarian cancer that originates in the germ (egg) cells of the ovary.

Wikipedia : 73 Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells... more...

Related Diseases for Ovarian Germ Cell Cancer

Diseases related to Ovarian Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 403)
# Related Disease Score Top Affiliating Genes
1 ovarian mixed germ cell neoplasm 31.8 KIT CEACAM5 AFP
2 mixed germ cell tumor 30.9 KIT AFP
3 germ cell cancer 30.7 SALL4 MIR302C KIT AFP
4 dysgerminoma of ovary 30.6 KIT AFP
5 ovarian embryonal carcinoma 30.5 GPC3 AFP
6 dysgerminoma 29.8 SALL4 MIR302C KRT7 KIT AFP
7 cystic teratoma 29.4 SYP NKX2-1 KRT7 KIT CALB2
8 endodermal sinus tumor 29.3 SALL4 MIR302C KRT7 GPC3 CEACAM5 AFP
9 mature teratoma 28.9 SYP SALL4 MIR302C KRT7 KIT CEACAM5
10 teratoma 28.6 SYP NKX2-1 KRT7 KIT GPC3 CEACAM5
11 benign teratoma 28.5 TG SYP SALL4 NKX2-1 KRT7 CEACAM5
12 malignant non-dysgerminomatous germ cell tumor of ovary 11.4
13 pediatric ovarian germ cell tumor 11.2
14 choriocarcinoma of the testis 10.4 SALL4 AFP
15 mature teratoma of the ovary 10.4 TG AFP
16 non-gestational choriocarcinoma 10.4 MIR302C AFP
17 embryonal carcinoma 10.4
18 athyreosis 10.3 TG NKX2-1
19 thymus sarcomatoid carcinoma 10.3 SYP AFP
20 ectopic thymus 10.3 TG NKX2-1
21 ovarian cystic teratoma 10.3 NKX2-1 AFP
22 central nervous system germ cell tumor 10.3 SALL4 AFP
23 pediatric germ cell cancer 10.3 MIR302C AFP
24 spindle epithelial tumor with thymus-like differentiation tumor 10.3 TG KIT
25 thymus basaloid carcinoma 10.3 SYP NKX2-1
26 lung meningioma 10.3 SYP NKX2-1
27 mediastinum seminoma 10.3 KIT AFP
28 ovary neuroendocrine neoplasm 10.3 SYP KRT7
29 mucinous bronchioloalveolar adenocarcinoma 10.3 NKX2-1 KRT7
30 auditory system benign neoplasm 10.3 SYP KRT7
31 gallbladder small cell carcinoma 10.3 SYP KRT7
32 middle ear adenoma 10.3 SYP KRT7
33 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP KRT7
34 papillary thyroid microcarcinoma 10.3 TG NKX2-1
35 sensory organ benign neoplasm 10.3 SYP KRT7
36 epithelioid trophoblastic tumor 10.3 SALL4 KRT7
37 ovarian large-cell neuroendocrine carcinoma 10.3 SYP KRT7
38 appendix adenocarcinoma 10.3 SYP KRT7
39 meibomian cyst 10.2 SYP KRT7
40 growing teratoma syndrome 10.2
41 pseudo-meigs syndrome 10.2
42 carcinoid tumors, intestinal 10.2 SYP NKX2-1
43 solid adenocarcinoma with mucin production 10.2 NKX2-1 KRT7
44 adult type testicular granulosa cell tumor 10.2 CALB2 AFP
45 thymus lipoma 10.2 KRT19 AFP
46 immune system organ benign neoplasm 10.2 KRT19 AFP
47 testicular malignant germ cell cancer 10.2 SALL4 GPC3 AFP
48 middle ear adenocarcinoma 10.2 TG KRT7 AFP
49 cervical adenoid cystic carcinoma 10.2 KRT7 KIT
50 middle ear carcinoma 10.2 TG KRT7 AFP

Graphical network of the top 20 diseases related to Ovarian Germ Cell Cancer:



Diseases related to Ovarian Germ Cell Cancer

Symptoms & Phenotypes for Ovarian Germ Cell Cancer

Clinical features from OMIM®:

603737 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Ovarian Germ Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.28 AFP CBL FANCM GPC3 KIT KRT19

Drugs & Therapeutics for Ovarian Germ Cell Cancer

Drugs for Ovarian Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 3 53-43-0 5881
7 Adjuvants, Immunologic Phase 3
8 Immunologic Factors Phase 3
9 DHEA (Dehydroepiandrosterone) Phase 3
10 Antimitotic Agents Phase 3
11 Etoposide phosphate Phase 3
12 Albumin-Bound Paclitaxel Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Tubulin Modulators Phase 3
15 Anti-Bacterial Agents Phase 3
16
Fondaparinux Approved, Investigational Phase 2 104993-28-4
17
protease inhibitors Phase 2
18 Fibrinolytic Agents Phase 2
19 Serine Proteinase Inhibitors Phase 2
20 Antithrombin III Phase 2
21 PENTA Phase 2
22 Antithrombins Phase 2
23 Factor Xa Inhibitors Phase 2
24 HIV Protease Inhibitors Phase 2
25 Anticoagulants Phase 2
26
Serine Investigational, Nutraceutical Phase 2 56-45-1 5951
27
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
28
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
29
Melphalan Approved Phase 1 148-82-3 4053 460612
30
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
31
Busulfan Approved, Investigational Phase 1 55-98-1 2478
32
Lenograstim Approved, Investigational Phase 1 135968-09-1
33
Thiotepa Approved, Investigational Phase 1 52-24-4 5453
34
Guadecitabine Investigational Phase 1 929901-49-5
35
Molgramostim Investigational Phase 1 99283-10-0
36 Antimetabolites Phase 1
37 Alkylating Agents Phase 1
38 Protective Agents Phase 1
39 Immunosuppressive Agents Phase 1
40 Radiation-Protective Agents Phase 1
41 Liver Extracts Phase 1
42 Cola

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Vaginal DHEA for Vaginal Symptoms: A Phase III Randomized, Double Blind, Placebo- Controlled Trial Completed NCT01376349 Phase 3 prasterone
2 A Multicenter, Prospective, Randomized Trial Comparing Paclitaxel and Carboplatin or Bleomycin, Etoposide and Cisplatin in the Treatment of Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
3 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
4 Women's Cancer Center Protocol #45: Prolonged Venous Thromboembolism Prophylaxis With Fondaparinux in Gynecologic Oncology Patients: An Open Label Phase II Trial Completed NCT00381888 Phase 2 fondaparinux sodium
5 Phase I Study of the Hypomethylating Drug SGI-110 Plus Cisplatin in Relapsed Refractory Germ Cell Tumors Completed NCT02429466 Phase 1 Guadecitabine (SGI-110)
6 Microvascular Perfusion Sonographic Imaging to Detect Early Stage Ovarian Cancer Completed NCT00626873 Phase 1 Definity
7 A Phase I Study of the Chemoprotectant Amifostine With Autologous Stem Cell Transplantation for High Risk or Relapsed Pediatric Solid Tumors and Brain Tumors Terminated NCT00003926 Phase 1 amifostine trihydrate;busulfan;filgrastim;melphalan;thiotepa
8 A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Ovarian Cancer in East Anglia, Oxford, Trent and West Midlands Unknown status NCT00757263
9 Northwestern Ovarian Cancer Early Detection & Prevention Program: A Specimen and Data Study Unknown status NCT00005095
10 A Randomized Controlled Trial to Investigate the Role of Low or High 'Fibre' Diets in Patients Undergoing Pelvic Radiotherapy - The Fibre Study Completed NCT01170299
11 Clinical Protocol to Evaluate Glycans Analysis As a Diagnostic Test for Ovarian Cancer Completed NCT00628654
12 The Rehabilitation Needs of People Who Have Had an Upper Gastrointestinal or a Gynecological Cancer Completed NCT01216813
13 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
14 Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. Recruiting NCT04283773
15 Quality of Life in Ovarian Germ Cell Cancer Survivors Terminated NCT00003794
16 Trends in Incidence and Survivals for Ovarian Germ Cell Tumors: A 27-Year Population-Based Study Withdrawn NCT00323726

Search NIH Clinical Center for Ovarian Germ Cell Cancer

Genetic Tests for Ovarian Germ Cell Cancer

Anatomical Context for Ovarian Germ Cell Cancer

MalaCards organs/tissues related to Ovarian Germ Cell Cancer:

40
Ovary, Thyroid, Liver, Lung, Thymus, Colon, Appendix

Publications for Ovarian Germ Cell Cancer

Articles related to Ovarian Germ Cell Cancer:

(show top 50) (show all 133)
# Title Authors PMID Year
1
Familial ovarian germ cell cancer: report and review. 57 61
10213045 1999
2
Incidence of the histologic types of ovarian cancer: the U.S. Third National Cancer Survey, 1969-1971. 57
881128 1977
3
Ovarian dysgerminoma in three generations? 57
5619989 1967
4
Cecal dermoid masquerading dermoid cyst of ovary: a case report and review of the literature. 61
33514417 2021
5
The individualized significance of lymphadenectomy across all age groups and histologies in malignant ovarian germ cell tumors. 61
32888090 2020
6
The youngest case of ovarian germ cell tumor in a Mayer-Rokitansky-Kuster-Hauser syndrome. 61
32773745 2020
7
A case series of patients with gonadal dysgenesis-associated mixed malignant ovarian germ cell tumor. 61
32516003 2020
8
Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery. 61
32179695 2020
9
RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report. 61
32974172 2020
10
Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness. 61
32774158 2020
11
Diary of a journey to a faraway galaxy. 61
31023193 2019
12
Therapeutic Challenges for Cisplatin-Resistant Ovarian Germ Cell Tumors. 61
31627378 2019
13
Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowth in a two-year-old female. 61
31038288 2019
14
Prognostic significance of residual disease in advanced stage malignant ovarian germ cell tumors. 61
30700566 2019
15
Long-term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor. 61
30289161 2019
16
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. 61
30086295 2018
17
Paraneoplastic Cytopenia in Ovarian Germ Cell Tumor: A Novel Presentation. 61
29240033 2018
18
Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? 61
29884437 2018
19
An unusual presentation of ovarian dermoid cyst: a case report and review of literature. 61
30018909 2018
20
Superinfection of mature ovarian cystic teratoma in a child: An unusual presentation. 61
30197369 2018
21
Germ Cell Tumor Ovary: an Institutional Experience of Treatment and Survival Outcomes. 61
29887704 2018
22
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. 61
30349318 2018
23
Fertility-sparing surgery in advanced stage malignant ovarian germ cell tumor: a case report. 61
29248013 2017
24
Fertility-preserving surgery for advanced stage ovarian germ cell tumors. 61
29021083 2017
25
High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report. 61
29062883 2017
26
Is Omentectomy Mandatory Among Early Stage (I, II) Malignant Ovarian Germ Cell Tumor Patients? A Retrospective Study of 223 Cases. 61
28520571 2017
27
Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. 61
28202195 2017
28
Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature. 61
28615984 2017
29
High Grade B- Cell Non- Hodgkin's Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report. 61
29988216 2017
30
Laparoscopic Treatment of Mixed Malignant Ovarian Germ Cell Tumor in a 16-Year-Old Female Adolescent. 61
27262834 2016
31
Ovarian cancer survivors' quality of life: a systematic review. 61
26884372 2016
32
A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary. 61
28485364 2016
33
Significance of the Complete Surgical Staging of Stage I Malignant Ovarian Germ Cell Tumors. 61
27112586 2016
34
Outcomes of Surgery Alone and Surveillance Strategy in Young Women With Stage I Malignant Ovarian Germ Cell Tumors. 61
27101582 2016
35
Primary Glial and Neuronal Tumors of the Ovary or Peritoneum: A Clinicopathologic Study of 11 Cases. 61
26990854 2016
36
Ovarian tumors secreting insulin. 61
25896552 2015
37
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". 61
25511159 2015
38
8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors. 61
25743840 2015
39
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. 61
25474425 2014
40
Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma. 61
25518772 2014
41
In vivo oocyte retrieval in a young woman with ovarian cancer. 61
25004306 2014
42
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis. 61
24836278 2014
43
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. 61
24681864 2014
44
Dermoid Cyst and its bizarre presentation. 61
26905716 2014
45
Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group. 61
24395845 2014
46
Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary. 61
24145115 2014
47
Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. 61
24716051 2014
48
Flagellate erythema. 61
24365007 2013
49
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. 61
24376332 2013
50
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. 61
23148694 2013

Variations for Ovarian Germ Cell Cancer

ClinVar genetic disease variations for Ovarian Germ Cell Cancer:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FANCM NM_020937.4(FANCM):c.5791C>T (p.Arg1931Ter) SNV Pathogenic 526381 rs144567652 GRCh37: 14:45667921-45667921
GRCh38: 14:45198718-45198718
2 CBL NM_005188.4(CBL):c.1228-2A>G SNV Likely pathogenic 177959 rs727504426 GRCh37: 11:119149218-119149218
GRCh38: 11:119278508-119278508

Expression for Ovarian Germ Cell Cancer

Search GEO for disease gene expression data for Ovarian Germ Cell Cancer.

Pathways for Ovarian Germ Cell Cancer

Pathways related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.83 KIT CBL

GO Terms for Ovarian Germ Cell Cancer

Biological processes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mast cell degranulation GO:0043303 8.96 KIT CBL
2 male gonad development GO:0008584 8.8 NCOA4 KIT CBL

Sources for Ovarian Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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