MOGCT
MCID: OVR112
MIFTS: 45

Ovarian Germ Cell Cancer (MOGCT)

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Cancer

MalaCards integrated aliases for Ovarian Germ Cell Cancer:

Name: Ovarian Germ Cell Cancer 56 12 58 15
Ovarian Germ Cell Tumor 12 52 54 17 71
Malignant Germ Cell Tumor of Ovary 58 6
Malignant Ovarian Germ Cell Neoplasm 71
Malignant Ovarian Germ Cell Tumor 58
Germ Cell Neoplasm of Ovary 12
Germ Cell Tumor of Ovary 12
Mogct 58

Characteristics:

Orphanet epidemiological data:

58
malignant germ cell tumor of ovary
Prevalence: <1/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (United States); Age of onset: Adolescent,Adult,Childhood,Elderly,Infancy; Age of death: any age;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:2156
OMIM 56 603737
NCIt 49 C3873
SNOMED-CT 67 237059008
ICD10 via Orphanet 33 C56
UMLS via Orphanet 72 C0346180
Orphanet 58 ORPHA35807
MedGen 41 C0346180
UMLS 71 C0238324 C0346180

Summaries for Ovarian Germ Cell Cancer

OMIM : 56 Ovarian germ cell cancers are malignancies that arise from germ cells of the embryonic gonad. Although benign germ cell tumors are relatively common, accounting for approximately 20% of all ovarian neoplasms, malignant ovarian germ cell tumors are rare. Weiss et al. (1977) estimated that less than 5% of ovarian cancers are of germ cell origin. (603737)

MalaCards based summary : Ovarian Germ Cell Cancer, also known as ovarian germ cell tumor, is related to ovarian mixed germ cell neoplasm and non-gestational choriocarcinoma. An important gene associated with Ovarian Germ Cell Cancer is CBL (Cbl Proto-Oncogene), and among its related pathways/superpathways is Regulation of KIT signaling. The drugs Vinblastine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone marrow and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An ovarian cancer that originates in the germ (egg) cells of the ovary.

Wikipedia : 74 Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells... more...

Related Diseases for Ovarian Germ Cell Cancer

Diseases related to Ovarian Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 417)
# Related Disease Score Top Affiliating Genes
1 ovarian mixed germ cell neoplasm 32.0 KIT CEACAM5 AFP
2 non-gestational choriocarcinoma 30.6 MIR302C AFP
3 gestational ovarian choriocarcinoma 30.5 CEACAM5 AFP
4 malignant teratoma 30.5 SYP SALL4 POU5F1 MIR302C KIT GPC3
5 mixed germ cell tumor 30.5 KIT AFP
6 embryonal carcinoma 30.2 POU5F1 MIR302C KIT AFP
7 ovarian embryonal carcinoma 30.1 POU5F1 GPC3 AFP
8 dysgerminoma of ovary 29.8 POU5F1 KIT AFP
9 testicular germ cell tumor 29.7 KIT GPC3 AFP
10 sertoli-leydig cell tumor 29.7 SYP MIR302C KRT7 CALB2 AFP
11 germ cell cancer 29.6 SALL4 POU5F1 MIR302C KIT AFP
12 germinoma 29.5 POU5F1 KIT AFP
13 seminoma 29.2 POU5F1 KIT GPC3 AFP
14 struma ovarii 29.2 TG NKX2-1 NCOA4 KRT7 KRT19
15 benign teratoma 28.9 TG SYP NKX2-1 KRT7 CEACAM5 CALB2
16 cystic teratoma 28.4 SYP NKX2-1 KRT7 KIT CEACAM5 CALB2
17 dysgerminoma 28.3 SALL4 POU5F1 MIR302C MIR202 KRT7 KIT
18 endodermal sinus tumor 28.1 SALL4 POU5F1 MIR302C KRT7 KIT GPC3
19 mature teratoma 27.6 TG SYP SALL4 POU5F1 MIR302C KRT7
20 teratoma 27.3 SYP POU5F1 NKX2-1 KRT7 KIT GPC3
21 malignant non-dysgerminomatous germ cell tumor of ovary 12.5
22 pediatric ovarian germ cell tumor 11.4
23 choriocarcinoma of the testis 10.5 SALL4 AFP
24 athyreosis 10.5 TG NKX2-1
25 childhood endodermal sinus tumor 10.5 SALL4 AFP
26 ovarian cystic teratoma 10.5 NKX2-1 AFP
27 ectopic thymus 10.4 TG NKX2-1
28 thymus sarcomatoid carcinoma 10.4 SYP AFP
29 lung meningioma 10.4 SYP NKX2-1
30 breast cystic hypersecretory carcinoma 10.4 TG CEACAM5
31 liver lipoma 10.4 CEACAM5 AFP
32 gastric neuroendocrine neoplasm 10.4 SYP MIR202
33 urachal adenocarcinoma 10.4 CEACAM5 AFP
34 ovary neuroendocrine neoplasm 10.4 SYP KRT7
35 rectum signet ring adenocarcinoma 10.4 CEACAM5 AFP
36 classic pulmonary blastoma 10.4 NKX2-1 CEACAM5
37 larynx sarcoma 10.4 NKX2-1 CEACAM5
38 pediatric germ cell cancer 10.4 MIR302C AFP
39 auditory system benign neoplasm 10.4 SYP KRT7
40 mucinous bronchioloalveolar adenocarcinoma 10.4 NKX2-1 KRT7
41 adult teratoma 10.4 CEACAM5 AFP
42 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP KRT7
43 middle ear adenoma 10.4 SYP KRT7
44 papillary thyroid microcarcinoma 10.4 TG NKX2-1
45 gallbladder small cell carcinoma 10.4 SYP KRT7
46 leukoplakia of penis 10.4 KRT7 CEACAM5
47 solid adenocarcinoma with mucin production 10.4 NKX2-1 KRT7
48 carcinoid tumors, intestinal 10.4 SYP NKX2-1
49 sensory organ benign neoplasm 10.4 SYP KRT7
50 urethral villous adenoma 10.4 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Ovarian Germ Cell Cancer:



Diseases related to Ovarian Germ Cell Cancer

Symptoms & Phenotypes for Ovarian Germ Cell Cancer

Clinical features from OMIM:

603737

GenomeRNAi Phenotypes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP

MGI Mouse Phenotypes related to Ovarian Germ Cell Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 GPC3 KIT KRT19 NKX2-1 POU5F1 SALL4
2 reproductive system MP:0005389 9.28 AFP CBL GPC3 KIT KRT19 NKX2-1

Drugs & Therapeutics for Ovarian Germ Cell Cancer

Drugs for Ovarian Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 225)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vinblastine Approved Phase 3 865-21-4 241903 13342
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
5
Ofloxacin Approved Phase 3 82419-36-1 4583
6
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Captopril Approved Phase 3 62571-86-2 44093
10
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
11
Ribavirin Approved Phase 3 36791-04-5 37542
12
Palivizumab Approved, Investigational Phase 3 188039-54-5
13
Acyclovir Approved Phase 3 59277-89-3 2022
14
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
15
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
16
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
17
Histamine Approved, Investigational Phase 3 51-45-6 774
18
Cyproheptadine Approved Phase 3 129-03-3 2913
19
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
20
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
21
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
22
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
23
Polyestradiol phosphate Approved Phase 3 28014-46-2
24
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 3 53-43-0 9860744
25 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
26 Anti-Bacterial Agents Phase 3
27 Alkylating Agents Phase 3
28 Liver Extracts Phase 3
29 Antitubercular Agents Phase 3
30 Antidotes Phase 3
31 Chelating Agents Phase 3
32 Anti-Infective Agents Phase 3
33 sodium thiosulfate Phase 3
34 Adjuvants, Immunologic Phase 3
35 Cola Phase 3
36 Anesthetics Phase 3
37 Narcotics Phase 3
38 Anesthetics, General Phase 3
39 Analgesics, Opioid Phase 3
40 Analgesics Phase 3
41 Anesthetics, Intravenous Phase 3
42 Antiviral Agents Phase 3
43
protease inhibitors Phase 3
44 HIV Protease Inhibitors Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3
46 DHEA (Dehydroepiandrosterone) Phase 3
47 Immunoglobulins Phase 3
48 Antibodies Phase 3
49 Antibodies, Monoclonal Phase 3
50 Hormones Phase 3

Interventional clinical trials:

(show top 50) (show all 141)
# Name Status NCT ID Phase Drugs
1 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
3 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
4 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
5 Vaginal DHEA for Vaginal Symptoms: A Phase III Randomized, Double Blind, Placebo- Controlled Trial Completed NCT01376349 Phase 3 prasterone
6 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
7 HSCT-CHESS to Enhance Hematopoietic Transplant Recovery Completed NCT00782145 Phase 3
8 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
9 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
10 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
11 A Phase III Multicenter Study of Cytomegalovirus Prophylaxis With Valacyclovir for the Prevention of Serious Fungal and Bacterial Infections Among Cytomegalovirus Seronegative Recipients of Cytomegalovirus Seropositive Sx Stem Cell Transplants Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
12 Music Video and Adolescent/Young Adult Resilience During Transplant Completed NCT00305851 Phase 3
13 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
14 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
15 A Multicenter, Prospective, Randomized Trial Comparing Paclitaxel and Carboplatin or Bleomycin, Etoposide and Cisplatin in the Treatment of Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
16 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
17 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
18 A Multiinstitutional Trial To Evaluate The Prophylactic Use Of NASA-Developed Light Emitting Diodes For The Prevention Of Oral Mucositis In Bone Marrow Transplant Patients Unknown status NCT00036712 Phase 2
19 A Phase IIA Trial of Continuous Five Day Infusions of MSI-1256F (Squalamine Lactate) Plus Carboplatin for Therapy of Refractory and Resistant Stage III and IV Ovarian Cancer Unknown status NCT00021385 Phase 2 carboplatin;squalamine lactate
20 Open-label, Multicenter, Phase I/II Trial to Evaluate Efficacy Safety of the Combination Therapy of Genexol-PM and Carboplatin as a Firstline Treatment in Subjects With Advanced Ovarian Cancer Unknown status NCT00886717 Phase 1, Phase 2 carboplatin;paclitaxel-loaded polymeric micelle
21 A Phase I-II Trial of Mild Whole-Body Hyperthermia Combined With Liposomal Doxorubicin/5-Fluorouracil in Patients With Advanced Malignancy Unknown status NCT00003135 Phase 2 fluorouracil;pegylated liposomal doxorubicin hydrochloride
22 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23 Systematic Nutritional Care in Patients Receiving First-line Chemotherapy for Metastatic Gynecologic Cancer in a Phase II Study Unknown status NCT00905658 Phase 2
24 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
25 Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
26 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
27 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
28 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
29 Phase II Trial of Temozolomide in Patients With Cisplatin-Refractory Germ Cell Tumors Completed NCT00006043 Phase 2 temozolomide
30 Phase II Study of Paclitaxel Plus Gemcitabine in Refractory Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
31 A Cancer Research UK Phase II Proof of Principle Trial of the Activity of the PARP-1 Inhibitor, AG-014699, in Known Carriers of a BRCA 1 or BRCA 2 Mutation With Locally Advanced or Metastatic Breast or Advanced Ovarian Cancer Completed NCT00664781 Phase 2 rucaparib (CO-338; formally AG-014699 or PF-01367338)
32 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
33 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
34 PROTOCOL FOR THE TREATMENT OF MALIGNANT NON-TESTICULAR GERM CELL TUMORS Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
35 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
36 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
37 Women's Cancer Center Protocol #45: Prolonged Venous Thromboembolism Prophylaxis With Fondaparinux in Gynecologic Oncology Patients: An Open Label Phase II Trial Completed NCT00381888 Phase 2 fondaparinux sodium
38 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
39 INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
40 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
41 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
42 PHASE I/II TRIAL OF TAXOL, IFOSFAMIDE, AND CISPLATIN FOR CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH FAVORABLE PROGNOSTIC FEATURES Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
43 High Dose Ifosfamide, Carboplatin and Etoposide With Amifostine Chemoprotection Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
44 Phase I/II Study of Escalating Dose Melphalan With Autologous Pluripotent Hematopoietic Stem Cell Support and Amifostine Cytoprotection in Cancer Patients Completed NCT00003425 Phase 1, Phase 2 amifostine trihydrate;cyclophosphamide;melphalan
45 A Phase I/IIA Dose-Escalating Trial of BCL-2 Antisense (G3139) Treatment for Patients With Androgen-Independent Prostate Cancer or Other Advanced Solid Tumor Malignancies Completed NCT00003103 Phase 1, Phase 2 docetaxel
46 A Phase I Evaluation of the Combination of Pegylated Liposomal Doxorubicin (Doxil®) With PS-341 in Patients With Refractory Hematologic and Solid Malignancies Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
47 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
48 PHASE I/II TRIAL OF SEQUENTIAL TAXOL/IFOSFAMIDE AND DOSEINTENSIVE CARBOPLATIN/ETOPOSIDE WITH STEM CELL SUPPORT IN CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH UNFAVORABLE PROGNOSTIC FEATURES Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
49 Phase II Clinical Trial Incorporating Alemtuzumab (Campath-1H) in Combination With FK506 and Methylprednisolone for Treatment of Severe Acute Graft vs Host Disease Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
50 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2

Search NIH Clinical Center for Ovarian Germ Cell Cancer

Genetic Tests for Ovarian Germ Cell Cancer

Anatomical Context for Ovarian Germ Cell Cancer

MalaCards organs/tissues related to Ovarian Germ Cell Cancer:

40
Ovary, Bone Marrow, Bone, Brain, Liver, Breast, T Cells

Publications for Ovarian Germ Cell Cancer

Articles related to Ovarian Germ Cell Cancer:

(show top 50) (show all 128)
# Title Authors PMID Year
1
Familial ovarian germ cell cancer: report and review. 61 56
10213045 1999
2
Incidence of the histologic types of ovarian cancer: the U.S. Third National Cancer Survey, 1969-1971. 56
881128 1977
3
Ovarian dysgerminoma in three generations? 56
5619989 1967
4
A case series of patients with gonadal dysgenesis-associated mixed malignant ovarian germ cell tumor. 61
32516003 2020
5
Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery. 61
32179695 2020
6
Diary of a journey to a faraway galaxy. 61
31023193 2019
7
Therapeutic Challenges for Cisplatin-Resistant Ovarian Germ Cell Tumors. 61
31627378 2019
8
Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowth in a two-year-old female. 61
31038288 2019
9
Prognostic significance of residual disease in advanced stage malignant ovarian germ cell tumors. 61
30700566 2019
10
Long-term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor. 61
30289161 2019
11
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. 61
30086295 2018
12
Paraneoplastic Cytopenia in Ovarian Germ Cell Tumor: A Novel Presentation. 61
29240033 2018
13
Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? 61
29884437 2018
14
Superinfection of mature ovarian cystic teratoma in a child: An unusual presentation. 61
30197369 2018
15
An unusual presentation of ovarian dermoid cyst: a case report and review of literature. 61
30018909 2018
16
Germ Cell Tumor Ovary: an Institutional Experience of Treatment and Survival Outcomes. 61
29887704 2018
17
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. 61
30349318 2018
18
Fertility-sparing surgery in advanced stage malignant ovarian germ cell tumor: a case report. 61
29248013 2017
19
Fertility-preserving surgery for advanced stage ovarian germ cell tumors. 61
29021083 2017
20
High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report. 61
29062883 2017
21
Is Omentectomy Mandatory Among Early Stage (I, II) Malignant Ovarian Germ Cell Tumor Patients? A Retrospective Study of 223 Cases. 61
28520571 2017
22
Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. 61
28202195 2017
23
Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature. 61
28615984 2017
24
High Grade B- Cell Non- Hodgkin's Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report. 61
29988216 2017
25
Laparoscopic Treatment of Mixed Malignant Ovarian Germ Cell Tumor in a 16-Year-Old Female Adolescent. 61
27262834 2016
26
Ovarian cancer survivors' quality of life: a systematic review. 61
26884372 2016
27
A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary. 61
28485364 2016
28
Significance of the Complete Surgical Staging of Stage I Malignant Ovarian Germ Cell Tumors. 61
27112586 2016
29
Primary Glial and Neuronal Tumors of the Ovary or Peritoneum: A Clinicopathologic Study of 11 Cases. 61
26990854 2016
30
Outcomes of Surgery Alone and Surveillance Strategy in Young Women With Stage I Malignant Ovarian Germ Cell Tumors. 61
27101582 2016
31
Ovarian tumors secreting insulin. 61
25896552 2015
32
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". 61
25511159 2015
33
8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors. 61
25743840 2015
34
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. 61
25474425 2014
35
Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma. 61
25518772 2014
36
In vivo oocyte retrieval in a young woman with ovarian cancer. 61
25004306 2014
37
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis. 61
24836278 2014
38
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. 61
24681864 2014
39
Dermoid Cyst and its bizarre presentation. 61
26905716 2014
40
Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group. 61
24395845 2014
41
Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. 61
24716051 2014
42
Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary. 61
24145115 2014
43
Flagellate erythema. 61
24365007 2013
44
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. 61
24376332 2013
45
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. 61
23148694 2013
46
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. 61
24222875 2013
47
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? 61
24475592 2013
48
Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. 61
23781595 2013
49
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. 61
23406948 2013
50
[Prognostic factors analysis in patients with ovarian malignant germ cell tumor treated with fertility-preserving surgery]. 61
23324188 2012

Variations for Ovarian Germ Cell Cancer

ClinVar genetic disease variations for Ovarian Germ Cell Cancer:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CBL NM_005188.4(CBL):c.1228-2A>GSNV Pathogenic/Likely pathogenic 177959 rs727504426 11:119149218-119149218 11:119278508-119278508
2 FANCM NM_020937.4(FANCM):c.5791C>T (p.Arg1931Ter)SNV Conflicting interpretations of pathogenicity 526381 rs144567652 14:45667921-45667921 14:45198718-45198718

Expression for Ovarian Germ Cell Cancer

Search GEO for disease gene expression data for Ovarian Germ Cell Cancer.

Pathways for Ovarian Germ Cell Cancer

Pathways related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.83 KIT CBL

GO Terms for Ovarian Germ Cell Cancer

Biological processes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.33 NCOA4 KIT CBL
2 mast cell degranulation GO:0043303 8.96 KIT CBL
3 somatic stem cell population maintenance GO:0035019 8.8 SALL4 POU5F1 KIT

Sources for Ovarian Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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