MOGCT
MCID: OVR112
MIFTS: 43

Ovarian Germ Cell Cancer (MOGCT)

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Cancer

MalaCards integrated aliases for Ovarian Germ Cell Cancer:

Name: Ovarian Germ Cell Cancer 57 12 59 15
Ovarian Germ Cell Tumor 12 53 55 17 72
Malignant Germ Cell Tumor of Ovary 59 6
Malignant Ovarian Germ Cell Neoplasm 72
Malignant Ovarian Germ Cell Tumor 59
Germ Cell Neoplasm of Ovary 12
Germ Cell Tumor of Ovary 12
Mogct 59

Characteristics:

Orphanet epidemiological data:

59
malignant germ cell tumor of ovary
Prevalence: <1/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (United States); Age of onset: Adolescent,Adult,Childhood,Elderly,Infancy; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:2156
OMIM 57 603737
NCIt 50 C3873
ICD10 via Orphanet 34 C56
UMLS via Orphanet 73 C0346180
Orphanet 59 ORPHA35807
MedGen 42 C0346180
UMLS 72 C0238324 C0346180

Summaries for Ovarian Germ Cell Cancer

OMIM : 57 Ovarian germ cell cancers are malignancies that arise from germ cells of the embryonic gonad. Although benign germ cell tumors are relatively common, accounting for approximately 20% of all ovarian neoplasms, malignant ovarian germ cell tumors are rare. Weiss et al. (1977) estimated that less than 5% of ovarian cancers are of germ cell origin. (603737)

MalaCards based summary : Ovarian Germ Cell Cancer, also known as ovarian germ cell tumor, is related to mature teratoma and struma ovarii. An important gene associated with Ovarian Germ Cell Cancer is TG (Thyroglobulin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Vinblastine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow, and related phenotype is digestive/alimentary.

Disease Ontology : 12 An ovarian cancer that originates in the germ (egg) cells of the ovary.

Wikipedia : 75 Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells... more...

Related Diseases for Ovarian Germ Cell Cancer

Diseases related to Ovarian Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 mature teratoma 30.9 TG AFP
2 struma ovarii 30.8 TG NKX2-1
3 ovarian embryonal carcinoma 30.5 GPC3 AFP
4 sertoli-leydig cell tumor 30.5 KRT7 AFP
5 endodermal sinus tumor 30.3 SALL4 GPC3 AFP
6 dysgerminoma of ovary 30.2 ENO2 AFP
7 testicular yolk sac tumor 30.0 SALL4 GPC3 AFP
8 carcinoid syndrome 29.8 SYP ENO2
9 malignant teratoma 29.4 SYP SALL4 ENO2 AFP
10 dysgerminoma 29.3 KRT7 ENO2 AFP
11 cystic teratoma 29.1 SYP NKX2-1 KRT7 ENO2
12 teratoma 28.4 SYP NKX2-1 KRT7 ENO2 AFP
13 malignant non-dysgerminomatous germ cell tumor of ovary 12.5
14 ovarian mixed germ cell neoplasm 11.5
15 pediatric ovarian germ cell tumor 11.4
16 follicular adenoma 10.6 TG NKX2-1
17 colloid adenoma 10.6 TG NKX2-1
18 athyreosis 10.6 TG NKX2-1
19 embryonal carcinoma 10.6
20 hypothyroidism, congenital, nongoitrous, 2 10.5 TG NKX2-1
21 fetal adenoma 10.5 TG NKX2-1
22 water-clear cell adenoma 10.5 TG SYP
23 papillary thyroid microcarcinoma 10.5 TG NKX2-1
24 mediastinal cancer 10.5 SYP AFP
25 male reproductive organ benign neoplasm 10.5 SYP AFP
26 pancreatoblastoma 10.4 SYP AFP
27 spermatocele 10.4 TG SYP
28 extragonadal seminoma 10.4 SALL4 AFP
29 testicular malignant germ cell cancer 10.4 GPC3 AFP
30 pineoblastoma 10.4 SYP AFP
31 pulmonary blastoma 10.4 SYP NKX2-1
32 hepatic adenomas, familial 10.4 GPC3 AFP
33 multinodular goiter 10.4 TG NKX2-1
34 tubular adenocarcinoma 10.3 SYP AFP
35 intrahepatic bile duct adenoma 10.3 KRT7 AFP
36 renal pelvis adenocarcinoma 10.3 KRT7 AFP
37 intratubular embryonal carcinoma 10.3 KRT7 AFP
38 germ cell cancer 10.3
39 bile duct cystadenocarcinoma 10.3 KRT7 AFP
40 growing teratoma syndrome 10.3
41 solid adenocarcinoma with mucin production 10.3 NKX2-1 KRT7
42 lung acinar adenocarcinoma 10.3 NKX2-1 KRT7
43 adenomatoid tumor 10.3 KRT7 AFP
44 choriocarcinoma of the testis 10.3 KRT7 AFP
45 papillary adenoma 10.3 NKX2-1 KRT7
46 malignant struma ovarii 10.3 TG NKX2-1 AFP
47 papillary serous adenocarcinoma 10.3 NKX2-1 KRT7
48 intestinal perforation 10.3 NKX2-1 KRT7
49 breast secretory carcinoma 10.3 TG KRT7
50 epithelioid trophoblastic tumor 10.3 SALL4 KRT7

Graphical network of the top 20 diseases related to Ovarian Germ Cell Cancer:



Diseases related to Ovarian Germ Cell Cancer

Symptoms & Phenotypes for Ovarian Germ Cell Cancer

Clinical features from OMIM:

603737

MGI Mouse Phenotypes related to Ovarian Germ Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GPC3 HLX NKX2-1 SALL4 TG

Drugs & Therapeutics for Ovarian Germ Cell Cancer

Drugs for Ovarian Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vinblastine Approved Phase 3 865-21-4 241903 13342
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4
Ofloxacin Approved Phase 3 82419-36-1 4583
5
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
6
Ribavirin Approved Phase 3 36791-04-5 37542
7
Palivizumab Approved, Investigational Phase 3 188039-54-5
8
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
9
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
10
Captopril Approved Phase 3 62571-86-2 44093
11
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
12
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
13
Acyclovir Approved Phase 3 59277-89-3 2022
14
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
15
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
16
Histamine Approved, Investigational Phase 3 51-45-6 774
17
Cyproheptadine Approved Phase 3 129-03-3 2913
18
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
19
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
20
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
21
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
22
Polyestradiol phosphate Approved Phase 3 28014-46-2
23
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 3 53-43-0 9860744
24 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
25 Alkylating Agents Phase 3
26 Immunologic Factors Phase 3
27 Immunosuppressive Agents Phase 3
28 Antineoplastic Agents, Alkylating Phase 3
29 sodium thiosulfate Phase 3
30 Liver Extracts Phase 3
31 Antitubercular Agents Phase 3
32 Adjuvants, Immunologic Phase 3
33 Antirheumatic Agents Phase 3
34 Cola Phase 3
35 Anesthetics, Intravenous Phase 3
36 Analgesics Phase 3
37 Narcotics Phase 3
38 Peripheral Nervous System Agents Phase 3
39 Adjuvants, Anesthesia Phase 3
40 Central Nervous System Depressants Phase 3
41 Anesthetics Phase 3
42 Anesthetics, General Phase 3
43 Analgesics, Opioid Phase 3
44 Antiviral Agents Phase 3
45 Antimetabolites Phase 3
46 HIV Protease Inhibitors Phase 3
47
protease inhibitors Phase 3
48 Renal Agents Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 3
50 Anti-Infective Agents, Urinary Phase 3

Interventional clinical trials:

(show top 50) (show all 137)
# Name Status NCT ID Phase Drugs
1 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
3 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
4 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
5 Vaginal DHEA for Vaginal Symptoms: A Phase III Randomized, Double Blind, Placebo- Controlled Trial Completed NCT01376349 Phase 3 prasterone
6 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
7 HSCT-CHESS to Enhance Hematopoietic Transplant Recovery Completed NCT00782145 Phase 3
8 Music Video and Adolescent/Young Adult Resilience During Transplant Completed NCT00305851 Phase 3
9 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
10 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
11 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
12 A Phase III Multicenter Study of Cytomegalovirus Prophylaxis With Valacyclovir for the Prevention of Serious Fungal and Bacterial Infections Among Cytomegalovirus Seronegative Recipients of Cytomegalovirus Seropositive Sx Stem Cell Transplants Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
13 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
14 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
15 A Multicenter, Prospective, Randomized Trial Comparing Paclitaxel and Carboplatin or Bleomycin, Etoposide and Cisplatin in the Treatment of Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
16 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
17 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
18 A Multiinstitutional Trial To Evaluate The Prophylactic Use Of NASA-Developed Light Emitting Diodes For The Prevention Of Oral Mucositis In Bone Marrow Transplant Patients Unknown status NCT00036712 Phase 2
19 Open-label, Multicenter, Phase I/II Trial to Evaluate Efficacy Safety of the Combination Therapy of Genexol-PM and Carboplatin as a Firstline Treatment in Subjects With Advanced Ovarian Cancer Unknown status NCT00886717 Phase 1, Phase 2 carboplatin;paclitaxel-loaded polymeric micelle
20 A Phase I-II Trial of Mild Whole-Body Hyperthermia Combined With Liposomal Doxorubicin/5-Fluorouracil in Patients With Advanced Malignancy Unknown status NCT00003135 Phase 2 fluorouracil;pegylated liposomal doxorubicin hydrochloride
21 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
22 Systematic Nutritional Care in Patients Receiving First-line Chemotherapy for Metastatic Gynecologic Cancer in a Phase II Study Unknown status NCT00905658 Phase 2
23 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
24 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
25 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
26 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
27 Phase II Trial of Temozolomide in Patients With Cisplatin-Refractory Germ Cell Tumors Completed NCT00006043 Phase 2 temozolomide
28 Phase II Study of Paclitaxel Plus Gemcitabine in Refractory Germ Cell Tumors Completed NCT00003518 Phase 2 gemcitabine hydrochloride;paclitaxel
29 A Cancer Research UK Phase II Proof of Principle Trial of the Activity of the PARP-1 Inhibitor, AG-014699, in Known Carriers of a BRCA 1 or BRCA 2 Mutation With Locally Advanced or Metastatic Breast or Advanced Ovarian Cancer Completed NCT00664781 Phase 2 rucaparib (CO-338; formally AG-014699 or PF-01367338)
30 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
31 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
32 PROTOCOL FOR THE TREATMENT OF MALIGNANT NON-TESTICULAR GERM CELL TUMORS Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
33 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
34 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
35 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
36 INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
37 Women's Cancer Center Protocol #45: Prolonged Venous Thromboembolism Prophylaxis With Fondaparinux in Gynecologic Oncology Patients: An Open Label Phase II Trial Completed NCT00381888 Phase 2 fondaparinux sodium
38 A Phase I/II Trial of Temodar in Pediatric Patients and Young Adults With High-Risk or Recurrent Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
39 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
40 PHASE I/II TRIAL OF TAXOL, IFOSFAMIDE, AND CISPLATIN FOR CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH FAVORABLE PROGNOSTIC FEATURES Completed NCT00002559 Phase 1, Phase 2 cisplatin;ifosfamide;paclitaxel
41 High Dose Ifosfamide, Carboplatin and Etoposide With Amifostine Chemoprotection Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
42 Phase I/II Study of Escalating Dose Melphalan With Autologous Pluripotent Hematopoietic Stem Cell Support and Amifostine Cytoprotection in Cancer Patients Completed NCT00003425 Phase 1, Phase 2 amifostine trihydrate;cyclophosphamide;melphalan
43 A Phase I/IIA Dose-Escalating Trial of BCL-2 Antisense (G3139) Treatment for Patients With Androgen-Independent Prostate Cancer or Other Advanced Solid Tumor Malignancies Completed NCT00003103 Phase 1, Phase 2 docetaxel
44 A Phase I Evaluation of the Combination of Pegylated Liposomal Doxorubicin (Doxil®) With PS-341 in Patients With Refractory Hematologic and Solid Malignancies Completed NCT00237627 Phase 1, Phase 2 PS-341;Doxil;Velcade
45 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
46 PHASE I/II TRIAL OF SEQUENTIAL TAXOL/IFOSFAMIDE AND DOSEINTENSIVE CARBOPLATIN/ETOPOSIDE WITH STEM CELL SUPPORT IN CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH UNFAVORABLE PROGNOSTIC FEATURES Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
47 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
48 Phase II Clinical Trial Incorporating Alemtuzumab (Campath-1H) in Combination With FK506 and Methylprednisolone for Treatment of Severe Acute Graft vs Host Disease Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
49 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
50 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2

Search NIH Clinical Center for Ovarian Germ Cell Cancer

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cyclophosphamide
Vincristine

Genetic Tests for Ovarian Germ Cell Cancer

Anatomical Context for Ovarian Germ Cell Cancer

MalaCards organs/tissues related to Ovarian Germ Cell Cancer:

41
Ovary, Bone, Bone Marrow, Brain, Liver, Breast, T Cells

Publications for Ovarian Germ Cell Cancer

Articles related to Ovarian Germ Cell Cancer:

(show top 50) (show all 125)
# Title Authors PMID Year
1
Familial ovarian germ cell cancer: report and review. 38 8
10213045 1999
2
Incidence of the histologic types of ovarian cancer: the U.S. Third National Cancer Survey, 1969-1971. 8
881128 1977
3
Ovarian dysgerminoma in three generations? 8
5619989 1967
4
Novel heterozygous mutation in the PTEN gene associated with ovarian germ cell tumor complicated by growing teratoma syndrome and overgrowth in a two-year-old female. 38
31038288 2019
5
Diary of a journey to a faraway galaxy. 38
31023193 2019
6
Prognostic significance of residual disease in advanced stage malignant ovarian germ cell tumors. 38
30700566 2019
7
Long-term neurotoxicity and Raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor. 38
30289161 2019
8
Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. 38
30086295 2018
9
Paraneoplastic Cytopenia in Ovarian Germ Cell Tumor: A Novel Presentation. 38
29240033 2018
10
Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? 38
29884437 2018
11
An unusual presentation of ovarian dermoid cyst: a case report and review of literature. 38
30018909 2018
12
Superinfection of mature ovarian cystic teratoma in a child: An unusual presentation. 38
30197369 2018
13
Germ Cell Tumor Ovary: an Institutional Experience of Treatment and Survival Outcomes. 38
29887704 2018
14
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. 38
30349318 2018
15
Fertility-sparing surgery in advanced stage malignant ovarian germ cell tumor: a case report. 38
29248013 2017
16
Fertility-preserving surgery for advanced stage ovarian germ cell tumors. 38
29021083 2017
17
High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report. 38
29062883 2017
18
Is Omentectomy Mandatory Among Early Stage (I, II) Malignant Ovarian Germ Cell Tumor Patients? A Retrospective Study of 223 Cases. 38
28520571 2017
19
Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. 38
28202195 2017
20
Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature. 38
28615984 2017
21
High Grade B- Cell Non- Hodgkin's Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report. 38
29988216 2017
22
Laparoscopic Treatment of Mixed Malignant Ovarian Germ Cell Tumor in a 16-Year-Old Female Adolescent. 38
27262834 2016
23
Ovarian cancer survivors' quality of life: a systematic review. 38
26884372 2016
24
A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary. 38
28485364 2016
25
Significance of the Complete Surgical Staging of Stage I Malignant Ovarian Germ Cell Tumors. 38
27112586 2016
26
Outcomes of Surgery Alone and Surveillance Strategy in Young Women With Stage I Malignant Ovarian Germ Cell Tumors. 38
27101582 2016
27
Primary Glial and Neuronal Tumors of the Ovary or Peritoneum: A Clinicopathologic Study of 11 Cases. 38
26990854 2016
28
Ovarian tumors secreting insulin. 38
25896552 2015
29
Fertility and gonadal function after adjuvant therapy in women diagnosed with a malignant ovarian germ cell tumor (MOGCT) during the "cisplatin era". 38
25511159 2015
30
8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors. 38
25743840 2015
31
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. 38
25474425 2014
32
Mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma. 38
25518772 2014
33
In vivo oocyte retrieval in a young woman with ovarian cancer. 38
25004306 2014
34
Malignant ovarian germ cell tumor - role of surgical staging and gonadal dysgenesis. 38
24836278 2014
35
Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor. 38
24681864 2014
36
Dermoid Cyst and its bizarre presentation. 38
26905716 2014
37
Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group. 38
24395845 2014
38
Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary. 38
24145115 2014
39
Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. 38
24716051 2014
40
Flagellate erythema. 38
24365007 2013
41
Bleomycin cardiotoxicity during chemotherapy for an ovarian germ cell tumor. 38
24376332 2013
42
Systemic thromboembolism after anti-cancer chemotherapy in a woman with ovarian germ cell tumor. 38
23148694 2013
43
Clinical and radiologic signs of relapsed ovarian germ cell tumor: tissue is the issue. 38
24222875 2013
44
Pelvic pain, free fluid in pelvis, and human chorionic gonadotropin serum elevation: recurrence of malignant ovarian germ-cell tumor or early pregnancy? 38
24475592 2013
45
Usefulness of intraoperative imprint cytology in ovarian germ cell tumors. 38
23406948 2013
46
Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. 38
23781595 2013
47
[Prognostic factors analysis in patients with ovarian malignant germ cell tumor treated with fertility-preserving surgery]. 38
23324188 2012
48
Minilaparotomy a good option in specific cases: a case report of bilateral ovarian germ cell tumor. 38
22567526 2012
49
Uncommon vascular tumor of the ovary. Primary ovarian epithelioid hemangioendothelioma or vascular sarcomatous transformation in ovarian germ cell tumor? 38
21822906 2011
50
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution. 38
21988930 2011

Variations for Ovarian Germ Cell Cancer

ClinVar genetic disease variations for Ovarian Germ Cell Cancer:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 FANCM NM_020937.4(FANCM): c.5791C> T (p.Arg1931Ter) single nucleotide variant Conflicting interpretations of pathogenicity rs144567652 14:45667921-45667921 14:45198718-45198718
2 CBL NM_005188.3(CBL): c.1228-2A> G single nucleotide variant Conflicting interpretations of pathogenicity rs727504426 11:119149218-119149218 11:119278508-119278508

Expression for Ovarian Germ Cell Cancer

Search GEO for disease gene expression data for Ovarian Germ Cell Cancer.

Pathways for Ovarian Germ Cell Cancer

Pathways related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 NKX2-1 AFP

GO Terms for Ovarian Germ Cell Cancer

Biological processes related to Ovarian Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 8.62 TG NKX2-1

Sources for Ovarian Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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