MCID: OVR109
MIFTS: 37

Ovarian Germ Cell Teratoma

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Ovarian Germ Cell Teratoma

MalaCards integrated aliases for Ovarian Germ Cell Teratoma:

Name: Ovarian Germ Cell Teratoma 12 15
Germ Cell Teratoma of Ovary 12
Ovarian Teratoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5567
NCIt 50 C8110
UMLS 73 C0280131

Summaries for Ovarian Germ Cell Teratoma

MalaCards based summary : Ovarian Germ Cell Teratoma, also known as germ cell teratoma of ovary, is related to growing teratoma syndrome and athyreosis. An important gene associated with Ovarian Germ Cell Teratoma is TG (Thyroglobulin), and among its related pathways/superpathways are GDNF-Family Ligands and Receptor Interactions and VEGF Pathway (Tocris). The drugs Etoposide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and bone marrow, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Ovarian Germ Cell Teratoma

Diseases related to Ovarian Germ Cell Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 growing teratoma syndrome 11.3
2 athyreosis 10.5 NKX2-1 TG
3 malignant teratoma 10.4 NKX2-1 TG
4 hypothyroidism, congenital, nongoitrous, 2 10.4 NKX2-1 TG
5 papillary thyroid microcarcinoma 10.4 NKX2-1 TG
6 thyroid gland disease 10.3 NKX2-1 TG
7 anaplastic thyroid cancer 10.3 NKX2-1 TG
8 multinodular goiter 10.3 NKX2-1 TG
9 nodular goiter 10.3 RET TG
10 mature teratoma of the ovary 10.3 NECTIN2 TG
11 thyroiditis 10.2 RET TG
12 congenital hypothyroidism 10.1 NKX2-1 TG
13 cowden disease 10.1 RET TG
14 goiter 10.0 NKX2-1 TG
15 solid adenocarcinoma with mucin production 10.0 KRT7 NKX2-1
16 cystadenofibroma 10.0 KRT7 TG
17 endocrine gland cancer 10.0 RET TG
18 lung acinar adenocarcinoma 10.0 KRT7 NKX2-1
19 small cell carcinoma of the bladder 10.0 KRT7 NKX2-1
20 breast secretory carcinoma 10.0 KRT7 TG
21 mucinous bronchioloalveolar adenocarcinoma 10.0 KRT7 NKX2-1
22 papillary adenoma 10.0 KRT7 NKX2-1
23 bronchiolo-alveolar adenocarcinoma 10.0 KRT7 NKX2-1
24 papillary serous adenocarcinoma 9.9 KRT7 NKX2-1
25 intestinal perforation 9.9 KRT7 NKX2-1
26 pulmonary sclerosing hemangioma 9.9 KRT7 NKX2-1
27 pleomorphic carcinoma 9.9 KRT7 NKX2-1
28 atypical choroid plexus papilloma 9.9 KRT7 NKX2-1
29 sclerosing hemangioma 9.9 KRT7 NKX2-1
30 germ cell and embryonal cancer 9.9 KRT7 TG
31 cystic teratoma 9.9 KRT7 NKX2-1
32 horseshoe kidney 9.9 KRT7 NKX2-1
33 hidradenocarcinoma 9.9 KRT7 NKX2-1
34 large cell neuroendocrine carcinoma 9.9 KRT7 NKX2-1
35 benign mesothelioma 9.9 KRT7 NKX2-1
36 mucinous adenocarcinoma 9.9 KRT7 NKX2-1
37 papillary adenocarcinoma 9.9 KRT7 NKX2-1
38 lung benign neoplasm 9.9 KRT7 NKX2-1
39 struma ovarii 9.9 NKX2-1 RET TG
40 follicular adenoma 9.9 NKX2-1 RET TG
41 adenosquamous carcinoma 9.9 KRT7 NKX2-1
42 thyroid carcinoma, familial medullary 9.8 NKX2-1 RET TG
43 thyroid cancer, nonmedullary, 1 9.8 NKX2-1 RET TG
44 hypothyroidism 9.8 NKX2-1 RET TG
45 small cell carcinoma 9.8 KRT7 NKX2-1
46 large cell carcinoma 9.8 KRT7 NKX2-1
47 benign struma ovarii 9.8 NRAS RET TG
48 renal-hepatic-pancreatic dysplasia 9.8 KRT7 RET
49 integumentary system cancer 9.8 KRT7 NRAS
50 merkel cell carcinoma 9.8 KRT7 NKX2-1

Graphical network of the top 20 diseases related to Ovarian Germ Cell Teratoma:



Diseases related to Ovarian Germ Cell Teratoma

Symptoms & Phenotypes for Ovarian Germ Cell Teratoma

MGI Mouse Phenotypes related to Ovarian Germ Cell Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 KRT7 NECTIN2 NKX2-1 NRAS RET
2 endocrine/exocrine gland MP:0005379 9.02 NECTIN2 NKX2-1 NRAS RET TG

Drugs & Therapeutics for Ovarian Germ Cell Teratoma

Drugs for Ovarian Germ Cell Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
2
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
3
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
4
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
5 Topoisomerase Inhibitors Phase 3,Phase 2
6 Dermatologic Agents Phase 3,Phase 2
7 Anti-Bacterial Agents Phase 3,Phase 2
8 Antibiotics, Antitubercular Phase 3,Phase 2
9 Etoposide phosphate Phase 3,Phase 2
10 Antimitotic Agents Phase 3,Phase 2,Not Applicable
11 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Not Applicable
12 Podophyllotoxin Phase 3 518-28-5
13 Keratolytic Agents Phase 3
14
Lenograstim Approved, Investigational Phase 2 135968-09-1
15
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
16
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
17
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
18
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
19
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
20
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
21
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
23
Doxil Approved June 1999 Phase 2 31703
24 Alkylating Agents Phase 2
25 Folic Acid Antagonists Phase 2
26 Nucleic Acid Synthesis Inhibitors Phase 2
27 Vitamin B Complex Phase 2
28 Immunosuppressive Agents Phase 2
29 Antidotes Phase 2
30 Anti-Infective Agents Phase 2
31 Protective Agents Phase 2
32 Antirheumatic Agents Phase 2
33 Antimetabolites Phase 2
34 Antimetabolites, Antineoplastic Phase 2
35 Calcium, Dietary Phase 2
36 Antineoplastic Agents, Alkylating Phase 2
37 Folate Nutraceutical Phase 2
38 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
2 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
3 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
4 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
5 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355
6 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 Not Applicable paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Ovarian Germ Cell Teratoma

Genetic Tests for Ovarian Germ Cell Teratoma

Anatomical Context for Ovarian Germ Cell Teratoma

MalaCards organs/tissues related to Ovarian Germ Cell Teratoma:

41
Ovary, Thyroid, Bone Marrow, Brain, Bone, Prostate, Pituitary

Publications for Ovarian Germ Cell Teratoma

Articles related to Ovarian Germ Cell Teratoma:

(show top 50) (show all 186)
# Title Authors Year
1
Cerebellar Differentiation in Ovarian Teratoma: A Report of 6 Cases. ( 29889717 )
2018
2
Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report. ( 29403279 )
2018
3
Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids. ( 29455317 )
2018
4
Immature ovarian teratoma with gliomatosis peritonei with adenocarcinomatous differentiation in one of the lymph node's metastasis. ( 29523036 )
2018
5
Ovarian teratoma associated Anti-N-methyl-D-aspartate receptor encephalitis: a difficult diagnosis with a favorable prognosis. ( 29780755 )
2018
6
Radioactive iodine (131)I uptake in an ovarian teratoma. ( 28800880 )
2017
7
Ovarian teratoma: A case from 15th-18th century Lisbon, Portugal. ( 28888390 )
2017
8
A Rare Presentation of the Syndrome of Inappropriate Antidiuretic Hormone in a 12-year old Female as the Initial Presentation of an Immature Ovarian Teratoma. ( 28818586 )
2017
9
Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature. ( 28615984 )
2017
10
Anti-n-Methyl-d-Aspartate-Receptor (NMDAR) Encephalitis in Association with Ovarian Teratoma. ( 28884051 )
2017
11
Anti-N-methyl-D-aspartate-receptor encephalitis due ovarian teratoma. ( 28867338 )
2017
12
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2017
13
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1. ( 28719514 )
2017
14
Simultaneous Presentation of Wilms Tumor and Immature Ovarian Teratoma in Beckwith-Wiedemann Syndrome. ( 28692553 )
2017
15
Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review. ( 28288660 )
2017
16
Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review. ( 28724848 )
2017
17
Immature Ovarian Teratoma: When to Give Adjuvant Therapy? ( 28859031 )
2017
18
Well-formed cerebellum and brainstem-like structures in a mature ovarian teratoma: Neuropathological observations. ( 28042664 )
2017
19
Ovarian Teratoma Associated with Coexisting anti-N-Methyl-D-Aspartate Receptor and Glial Fibrillary Acidic Protein Autoimmune Meningoencephalitis in an Adolescent Girl: A Case Report. ( 29294378 )
2017
20
Immature ovarian teratoma in two heifers. ( 29307128 )
2017
21
Lower abdominal gossypiboma mimics ovarian teratoma: a case report and review of the literature. ( 28061867 )
2017
22
Gliomatosis peritonei with bilateral ovarian teratomas: A report of two cases. ( 27602142 )
2016
23
Prostate-Type Adenocarcinoma in Mature Cystic Ovarian Teratoma. ( 26352547 )
2016
24
Benign enhancing components of mature ovarian teratoma: magnetic resonance imaging features and pathologic correlation. ( 27568071 )
2016
25
Ovarian teratoma development after anti-NMDA receptor encephalitis treatment. ( 28040316 )
2016
26
An Uncommon Case of Adolescent Ovarian Teratoma Incarcerated in Inguinal Hernia. ( 27525145 )
2016
27
Ovarian teratomas in a patient with Bardet-Biedl syndrome, a rare association. ( 28174811 )
2016
28
Ovarian teratoma in an adult female Zoogoneticus tequila (Webb & Miller 1998): histological and immunohistochemical features. ( 27592861 )
2016
29
Paraneoplastic syndromes revealing ovarian teratoma in young and menopausal women: report of two cases. ( 27795759 )
2016
30
Acute reversible seronegative cerebellar ataxia in a young woman with ovarian teratoma. ( 27653894 )
2016
31
Rapid recovery from catastrophic paraneoplastic anti-NMDAR encephalitis secondary to an ovarian teratoma following ovarian cystectomy. ( 27511754 )
2016
32
Adult dermatomyositis associated with benign ovarian teratoma: A case report. ( 27073526 )
2016
33
Pseudomyxoma peritonei of a mature ovarian teratoma caused by mismatch repair deficiency in a patient with Lynch syndrome: a case report. ( 27938333 )
2016
34
Management of Familial Ovarian Teratoma: The Need for Guidance. ( 28018806 )
2016
35
Anti-N-methyl-D-aspartate receptor encephalitis associated with an ovarian teratoma: two cases report and anesthesia considerations. ( 26475263 )
2015
36
Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma: Description of a case and anesthetic implications. ( 25804681 )
2015
37
Bulbar and Limb Myorhythmia with "Smooch Sign": A Distinctive Movement Disorder in an Adult Patient with Reversible Anti-NMDA Receptor Encephalitis Associated with an Ovarian Teratoma. ( 26630807 )
2015
38
Squamous Cell Carcinoma Arising in Ovarian Teratoma: A Diagnostic Conundrum. ( 27217690 )
2015
39
Non-N-Methyl-D-Aspartate Receptor Antibody Encephalitis With Cerebellitis With Associated Ovarian Teratoma. ( 26551960 )
2015
40
Bilateral Ovarian Teratoma: One Parasitic Twisted In-situ and Another Parasitic at the Hepato Renal Space. ( 26744205 )
2015
41
Does MAP2 have a role in predicting the development of anti-NMDAR encephalitis associated with benign ovarian teratoma? A report of six new pediatric cases. ( 25569473 )
2015
42
Spontaneous Regression of Thoracic and Extraperitoneal Glial Implants in Child With Gliomatosis Peritonei After Resection of Ovarian Teratoma. ( 25089607 )
2014
43
Malignant transformations in ovarian teratomas: a report of four cases. ( 25252524 )
2014
44
Ovarian Teratoma with Predominant Hemangiomatous Component in Early Childhood. ( 25256876 )
2014
45
The N-methyl-D-aspartate receptor, a precursor to N-methyl-D-aspartate receptor encephalitis, is found in the squamous tissue of ovarian teratomas. ( 25272299 )
2014
46
Mature ovarian teratoma-associated limbic encephalitis. ( 25093683 )
2014
47
A Case of Anti-NMDAR Encephalitis Induced by Ovarian Teratoma. ( 25377541 )
2014
48
Conservative treatment of a young patient with thyroid carcinoma in adult ovarian teratoma - case report. ( 24397359 )
2014
49
Ovarian teratoma-associated anti-NMDAR encephalitis: a systematic review of reported cases. ( 25312434 )
2014
50
Longitudinally extensive transverse myelitis with AQP4 antibodies revealing ovarian teratoma. ( 23899665 )
2013

Variations for Ovarian Germ Cell Teratoma

Expression for Ovarian Germ Cell Teratoma

Search GEO for disease gene expression data for Ovarian Germ Cell Teratoma.

Pathways for Ovarian Germ Cell Teratoma

Pathways related to Ovarian Germ Cell Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 NRAS RET
2
Show member pathways
11.07 NRAS RET
3 10.77 NRAS RET
4 10.3 NRAS RET

GO Terms for Ovarian Germ Cell Teratoma

Biological processes related to Ovarian Germ Cell Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 8.96 NKX2-1 TG
2 axon guidance GO:0007411 8.8 NKX2-1 NRAS RET

Sources for Ovarian Germ Cell Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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