MCID: OVR109
MIFTS: 32

Ovarian Germ Cell Teratoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Teratoma

MalaCards integrated aliases for Ovarian Germ Cell Teratoma:

Name: Ovarian Germ Cell Teratoma 12 15
Germ Cell Teratoma of Ovary 12
Ovarian Teratoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5567
NCIt 50 C8110
SNOMED-CT 67 716077006
UMLS 70 C0280131

Summaries for Ovarian Germ Cell Teratoma

MalaCards based summary : Ovarian Germ Cell Teratoma, also known as germ cell teratoma of ovary, is related to childhood teratoma of the ovary and growing teratoma syndrome. An important gene associated with Ovarian Germ Cell Teratoma is TG (Thyroglobulin). The drugs Etoposide and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and bone marrow.

Related Diseases for Ovarian Germ Cell Teratoma

Diseases related to Ovarian Germ Cell Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 childhood teratoma of the ovary 11.3
2 growing teratoma syndrome 11.3
3 athyreosis 10.3 TG NKX2-1
4 ectopic thymus 10.3 TG NKX2-1
5 thyroid angiosarcoma 10.3 TG NKX2-1
6 thymus basaloid carcinoma 10.3 SYP NKX2-1
7 lung meningioma 10.3 SYP NKX2-1
8 laryngeal small cell carcinoma 10.3 SYP NKX2-1
9 papillary thyroid microcarcinoma 10.3 TG NKX2-1
10 lymphangitis 10.3 SIGLEC5 NKX2-1
11 perivascular epithelioid cell tumor 10.3 SYP NKX2-1
12 carcinoid tumors, intestinal 10.2 SYP NKX2-1
13 immature teratoma of ovary 10.2 TG AFP
14 pulmonary neuroendocrine tumor 10.2 SYP NKX2-1
15 acinar cell cystadenocarcinoma 10.2 SYP KRT19
16 non-gestational choriocarcinoma 10.2 MIR302C AFP
17 thymus sarcomatoid carcinoma 10.2 SYP AFP
18 hypothyroidism, congenital, nongoitrous, 2 10.2 TG NKX2-1
19 pineal region teratoma 10.2 SYP AFP
20 tracheal lymphoma 10.2 SYP KRT19
21 lung sarcomatoid carcinoma 10.2 NKX2-1 CALB2
22 lung sarcoma 10.2 NKX2-1 CALB2
23 common bile duct disease 10.2 MIR302C AFP
24 esophageal adenoid cystic carcinoma 10.2 SYP AFP
25 pediatric germ cell cancer 10.2 MIR302C AFP
26 myoblastoma 10.2 SYP CALB2
27 ovarian endometrioid stromal sarcoma 10.1 SYP CALB2
28 ureter adenocarcinoma 10.1 NKX2-1 KRT7
29 carotid body cancer 10.1 TG SYP NKX2-1
30 gallbladder leiomyosarcoma 10.1 KRT19 AFP
31 thymus lipoma 10.1 KRT19 AFP
32 immune system organ benign neoplasm 10.1 KRT19 AFP
33 ovary neuroendocrine neoplasm 10.1 SYP KRT7
34 mucinous adenofibroma 10.1 SYP KRT7
35 auditory system benign neoplasm 10.1 SYP KRT7
36 mucinous bronchioloalveolar adenocarcinoma 10.1 NKX2-1 KRT7
37 microcystic adenoma 10.1 SYP KRT19
38 paratesticular lipoma 10.1 KRT19 AFP
39 lipoma of spermatic cord 10.1 KRT19 AFP
40 pancreatic serous cystadenocarcinoma 10.1 SYP KRT7
41 vaginal tubulovillous adenoma 10.1 SYP KRT7
42 gallbladder small cell carcinoma 10.1 SYP KRT7
43 middle ear adenoma 10.1 SYP KRT7
44 pineal gland cancer 10.1 SYP AFP
45 krukenberg carcinoma 10.1 SYP KRT7
46 urinary bladder small cell neuroendocrine carcinoma 10.1 SYP KRT7
47 papillary squamous carcinoma 10.1 SYP KRT7
48 jejunal neoplasm 10.1 SYP KRT7
49 sensory organ benign neoplasm 10.1 SYP KRT7
50 sclerosing hepatic carcinoma 10.1 KRT19 AFP

Graphical network of the top 20 diseases related to Ovarian Germ Cell Teratoma:



Diseases related to Ovarian Germ Cell Teratoma

Symptoms & Phenotypes for Ovarian Germ Cell Teratoma

Drugs & Therapeutics for Ovarian Germ Cell Teratoma

Drugs for Ovarian Germ Cell Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
3
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
4
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
5
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
6
leucovorin Approved Phase 2 58-05-9 6006
7
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
8
Lenograstim Approved, Investigational Phase 2 135968-09-1
9
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
10
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
11
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
12 Vitamin B9 Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Trace Elements Phase 2
15 Nutrients Phase 2
16 Immunosuppressive Agents Phase 2
17 Micronutrients Phase 2
18
Liposomal doxorubicin Phase 2 31703
19 Alkylating Agents Phase 2
20 Immunologic Factors Phase 2
21 Folate Phase 2
22 Anti-Infective Agents Phase 2
23 Antirheumatic Agents Phase 2
24 Vitamin B Complex Phase 2
25 Folic Acid Antagonists Phase 2
26 Etoposide phosphate Phase 2
27 Vitamins Phase 2
28 Anti-Bacterial Agents Phase 2
29 Dermatologic Agents Phase 2
30 Antidotes Phase 2
31 Antimetabolites Phase 2
32 Calcium, Dietary Phase 2
33 Protective Agents Phase 2
34
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PROTOCOL FOR THE TREATMENT OF MALIGNANT NON-TESTICULAR GERM CELL TUMORS Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
2 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
3 Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Study of Nab-Paclitaxel (Nanoparticle Albumin Bound-Paclitaxel) in Patients With Advanced Solid Tumors Withdrawn NCT00499291 paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Ovarian Germ Cell Teratoma

Genetic Tests for Ovarian Germ Cell Teratoma

Anatomical Context for Ovarian Germ Cell Teratoma

MalaCards organs/tissues related to Ovarian Germ Cell Teratoma:

40
Ovary, Thyroid, Bone Marrow, Bone, Pituitary, Cerebellum, Lymph Node

Publications for Ovarian Germ Cell Teratoma

Articles related to Ovarian Germ Cell Teratoma:

(show top 50) (show all 1063)
# Title Authors PMID Year
1
Mucinous Cystic Adenoma of the Liver: A Thought-Provoking Case of an Uncommon Hepatic Neoplasm. 61
33811210 2021
2
Distinctive pattern of left-right asymmetry of ovarian benign teratomas in Chinese population: a 12-year-long cross-sectional study. 61
33427916 2021
3
Syringic acid regulates suppression of the STAT3/JNK/AKT pathway via inhibition of human ovarian teratoma cancer cell (PA-1) growth-in vitro study. 61
33759321 2021
4
Ovarian teratoma masquerading as encephalitis in an adolescent. 61
33773057 2021
5
Struma ovarii in bilateral ovarian teratoma-case report and literature review. 61
33732424 2021
6
Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma. 61
32873866 2021
7
[Anti-N-methyl-D-aspartate receptor encephalitis and ovarian teratoma]. 61
32659454 2021
8
VNS Stopping Anti-NMDA Receptor Encephalitis-Triggered Nonconvulsive Status Epilepticus. 61
33091646 2021
9
DDB2 regulates DNA replication through PCNA-independent degradation of CDT2. 61
33557942 2021
10
Ovarian Sparing Surgery in Mature Ovarian Teratomas in Children: A 20-Year Single-Center Experience. 61
32950035 2021
11
Cycloid psychosis as a psychiatric expression of anti-NMDAR encephalitis. A systematic review of case reports accomplished with the authors' cooperation. 61
33270360 2021
12
Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker. 61
33583072 2021
13
Anti-N-Methyl-D-Aspartate Receptor Encephalitis with Decrease in Blood Flow in Cerebellum. 61
33613239 2021
14
LINC00324 facilitates cell proliferation through competing for miR‑214‑5p in immature ovarian teratocarcinoma. 61
33416104 2021
15
Distinct cerebral 18F-FDG PET metabolic patterns in anti-N-methyl-D-aspartate receptor encephalitis patients with different trigger factors. 61
33717212 2021
16
Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations. 61
32743766 2021
17
Clinical Characteristics and Outcome of Neuronal Surface Antibody-Mediated Autoimmune Encephalitis Patients in a National Cohort. 61
33767656 2021
18
Mature ovarian teratoma associated with anti-N-Methyl-D-aspartate receptor encephalitis: A case report. 61
33510121 2021
19
Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in Korea. 61
33498105 2021
20
Ovarian teratoma with pituitary tissue: A case report. 61
33364180 2021
21
Clinical analysis of five case reports of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis. 61
33440951 2021
22
Occult Growing Teratoma as the Cause of Protracted Symptoms in a Patient with Anti-NMDA-Receptor Encephalitis and Prior Ovarian Teratoma Removal: Implications for Continued Monitoring and Treatment. 61
33480209 2021
23
Homemade Glove Retrieval Bag in Laparoscopic Complete Excision of Benign Ovarian Teratoma with Ovarian Tissue Preservation in Children: A Case Series. 61
32781234 2020
24
Follicular carcinoma arising from struma ovarii. A case report. 61
33393527 2020
25
Single nucleotide polymorphism array and cytogenetic analyses of ovarian teratomas in children. 61
33377559 2020
26
Multiple ectopic goiter in the retroperitoneum, abdominal wall, liver, and diaphragm: A case report and review of literature. 61
33344620 2020
27
Struma ovarii: two case reports of a rare teratoma of the ovary. 61
33343869 2020
28
A mature cystic teratoma adherent to the vaginal wall: a case report. 61
33233994 2020
29
Paraneoplastic anti-NMDA receptor encephalitis in 1830? 61
32978290 2020
30
Ovarian teratoma-associated anti-NMDAR encephalitis in a 12-year-old girl. 61
33219185 2020
31
Ovarian teratoma in a woodchuck (Marmota monax) with hepatocellular carcinoma: radiologic and pathologic features. 61
33228678 2020
32
Ovarian teratoma-associated anti-NMDAR encephalitis: a single-institute series of six patients from China. 61
33216164 2020
33
HLA-A and HLA-DRB1 may play a unique role in ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis. 61
33160385 2020
34
Coexistence of endometriosis in women with mature cystic ovarian teratoma may not be rare. 61
32413526 2020
35
A refractory anti-NMDA receptor encephalitis successfully treated by bilateral salpingo-oophorectomy and intrathecal injection of methotrexate and dexamethasone: a case report. 61
33100078 2020
36
Oily Ascites Revealing a Spontaneous Rupture of a Mature Ovarian Cystic Teratoma. 61
32964191 2020
37
Expression of SMAD4 is Retained in Most Gynecologic Tumors with Mucinous Differentiation. 61
31569186 2020
38
Anti-NMDA receptor encephalitis associated with ovarian tumor: the gynecologist point of view. 61
32556515 2020
39
Anti-NMDA receptor encephalitis with neurologic sequelae refractory to conservative therapy with complete response to adjuvant therapy. 61
32596435 2020
40
Opsoclonus-ataxia syndrome and mature ovarian teratoma in an adolescent. 61
32637527 2020
41
Commentary on "Psychosis associated to CASPR2 autoantibodies and ovarian teratoma: A case report". 61
32505929 2020
42
Single-cell transcriptional profiling identifies a cluster of potential metastasis-associated UBE2C+ cells in immature ovarian teratoma. 61
32505346 2020
43
BRAF Wild-type, PTEN Mutant Malignant Uveal Melanoma Arising Within a Mature Ovarian Teratoma: A Case Report and Review of the Literature. 61
31157687 2020
44
Squamous Cell Carcinoma from Abscessed, Mature Cystic Ovarian Teratoma - A Case Report and Literature Review. 61
32606195 2020
45
A Hairbrained Mature Cystic Ovarian Teratoma: With Bone Marrow, Meninges, and Intraglial Hair. 61
32489128 2020
46
When a mimicker wears strange faces: description of an osteogenic melanoma arising within an ovarian teratoma with focus on its late peritoneal relapse. 61
32633344 2020
47
Anti-N-methyl-D-aspartate Receptor Encephalitis: a Rare Complication of Ovarian Teratoma. 61
32567259 2020
48
Neurologic Presentation of Probable Seronegative Paraneoplastic Encephalitis in a Woman With an Ovarian Teratoma. 61
32656003 2020
49
Fetal Glomeruli in a Mature Ovarian Teratoma: A Developmental Anomaly Within a Developmental Anomaly? 61
31558071 2020
50
Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery. 61
32179695 2020

Variations for Ovarian Germ Cell Teratoma

Expression for Ovarian Germ Cell Teratoma

Search GEO for disease gene expression data for Ovarian Germ Cell Teratoma.

Pathways for Ovarian Germ Cell Teratoma

GO Terms for Ovarian Germ Cell Teratoma

Biological processes related to Ovarian Germ Cell Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 8.62 TG NKX2-1

Sources for Ovarian Germ Cell Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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