MCID: OVR109
MIFTS: 37

Ovarian Germ Cell Teratoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Germ Cell Teratoma

MalaCards integrated aliases for Ovarian Germ Cell Teratoma:

Name: Ovarian Germ Cell Teratoma 12 15
Germ Cell Teratoma of Ovary 12
Ovarian Teratoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5567
NCIt 50 C8110
UMLS 73 C0280131

Summaries for Ovarian Germ Cell Teratoma

MalaCards based summary : Ovarian Germ Cell Teratoma, also known as germ cell teratoma of ovary, is related to childhood teratoma of the ovary and growing teratoma syndrome. An important gene associated with Ovarian Germ Cell Teratoma is TG (Thyroglobulin), and among its related pathways/superpathways are VEGF Pathway (Tocris) and Central carbon metabolism in cancer. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and thyroid, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Ovarian Germ Cell Teratoma

Diseases related to Ovarian Germ Cell Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 childhood teratoma of the ovary 11.3
2 growing teratoma syndrome 11.3
3 colloid adenoma 10.1 NKX2-1 TG
4 athyreosis 10.1 NKX2-1 TG
5 hypothyroidism, congenital, nongoitrous, 2 10.1 NKX2-1 TG
6 papillary thyroid microcarcinoma 10.1 NKX2-1 TG
7 goiter 10.1 NKX2-1 TG
8 teratoma 10.1 KRT7 NKX2-1
9 cystic teratoma 10.1 KRT7 NKX2-1
10 solid adenocarcinoma with mucin production 10.1 KRT7 NKX2-1
11 cystadenofibroma 10.1 KRT7 TG
12 lung acinar adenocarcinoma 10.1 KRT7 NKX2-1
13 small cell carcinoma of the bladder 10.1 KRT7 NKX2-1
14 breast secretory carcinoma 10.1 KRT7 TG
15 small cell carcinoma 10.1 KRT7 NKX2-1
16 papillary adenoma 10.1 KRT7 NKX2-1
17 papillary serous adenocarcinoma 10.1 KRT7 NKX2-1
18 intestinal perforation 10.1 KRT7 NKX2-1
19 pulmonary sclerosing hemangioma 10.1 KRT7 NKX2-1
20 nodular goiter 10.1 RET TG
21 sclerosing hemangioma 10.1 KRT7 NKX2-1
22 hemangioma 10.1 NKX2-1 RET
23 multinodular goiter 10.1 NKX2-1 TG
24 adenomatoid tumor 10.1 KRT7 NKX2-1
25 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT7 NKX2-1
26 pleomorphic carcinoma 10.1 KRT7 NKX2-1
27 alveoli adenoma 10.1 KRT7 NKX2-1
28 mature teratoma of the ovary 10.1 NECTIN2 TG
29 atypical choroid plexus papilloma 10.1 KRT7 NKX2-1
30 horseshoe kidney 10.1 KRT7 NKX2-1
31 hidradenocarcinoma 10.1 KRT7 NKX2-1
32 large cell neuroendocrine carcinoma 10.1 KRT7 NKX2-1
33 mucinous adenocarcinoma 10.1 KRT7 NKX2-1
34 anaplastic thyroid cancer 10.1 NKX2-1 TG
35 papillary adenocarcinoma 10.1 KRT7 NKX2-1
36 bronchiolo-alveolar adenocarcinoma 10.1 KRT7 NKX2-1
37 lung benign neoplasm 10.1 KRT7 NKX2-1
38 thyroiditis 10.1 RET TG
39 cavernous hemangioma 10.1 KRT7 NKX2-1
40 adenosquamous carcinoma 10.0 KRT7 NKX2-1
41 cell type benign neoplasm 10.0 KRT7 TG
42 large cell carcinoma 10.0 KRT7 NKX2-1
43 renal-hepatic-pancreatic dysplasia 10.0 KRT7 RET
44 merkel cell carcinoma 10.0 KRT7 NKX2-1
45 mucoepidermoid carcinoma 10.0 KRT7 TG
46 intestinal obstruction 10.0 KRT7 RET
47 cowden disease 10.0 RET TG
48 thymus cancer 10.0 KRT7 NKX2-1
49 endocrine gland cancer 10.0 RET TG
50 congenital hypothyroidism 10.0 NKX2-1 TG

Graphical network of the top 20 diseases related to Ovarian Germ Cell Teratoma:



Diseases related to Ovarian Germ Cell Teratoma

Symptoms & Phenotypes for Ovarian Germ Cell Teratoma

MGI Mouse Phenotypes related to Ovarian Germ Cell Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 KRT7 NECTIN2 NKX2-1 NRAS RET
2 digestive/alimentary MP:0005381 9.26 NKX2-1 NRAS RET TG
3 endocrine/exocrine gland MP:0005379 9.02 NECTIN2 NKX2-1 NRAS RET TG

Drugs & Therapeutics for Ovarian Germ Cell Teratoma

Drugs for Ovarian Germ Cell Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
2
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
3
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
4
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
5 Antibiotics, Antitubercular Phase 3,Phase 2
6 Anti-Bacterial Agents Phase 3,Phase 2
7 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Not Applicable
8 Antimitotic Agents Phase 3,Phase 2,Not Applicable
9 Etoposide phosphate Phase 3,Phase 2
10 Topoisomerase Inhibitors Phase 3,Phase 2
11 Dermatologic Agents Phase 3,Phase 2
12 Keratolytic Agents Phase 3
13 Podophyllotoxin Phase 3 518-28-5
14
Dactinomycin Approved, Investigational Phase 2 50-76-0 457193 2019
15
leucovorin Approved Phase 2 58-05-9 6006 143
16
Lenograstim Approved, Investigational Phase 2 135968-09-1
17
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
18
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
19
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
20
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
21
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
23
Doxil Approved June 1999 Phase 2 31703
24 Vitamin B9 Phase 2
25 Protective Agents Phase 2
26 Antineoplastic Agents, Alkylating Phase 2
27 Nucleic Acid Synthesis Inhibitors Phase 2
28 Folic Acid Antagonists Phase 2
29 Calcium, Dietary Phase 2
30 Vitamin B Complex Phase 2
31 Immunologic Factors Phase 2
32 Alkylating Agents Phase 2
33 Antimetabolites, Antineoplastic Phase 2
34 Antirheumatic Agents Phase 2
35 Anti-Infective Agents Phase 2
36 Immunosuppressive Agents Phase 2
37 Folate Phase 2
38 Antidotes Phase 2
39 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
2 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
3 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
4 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
5 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
6 Oxidative Stress Gene Polymorphism and Ovarian Reserve Functione Not yet recruiting NCT03682341
7 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 Not Applicable paclitaxel albumin-stabilized nanoparticle formulation

Search NIH Clinical Center for Ovarian Germ Cell Teratoma

Genetic Tests for Ovarian Germ Cell Teratoma

Anatomical Context for Ovarian Germ Cell Teratoma

MalaCards organs/tissues related to Ovarian Germ Cell Teratoma:

41
Ovary, Bone, Thyroid, Bone Marrow, Thymus, Lung, Kidney

Publications for Ovarian Germ Cell Teratoma

Articles related to Ovarian Germ Cell Teratoma:

(show top 50) (show all 229)
# Title Authors Year
1
Ocular structures in a mature ovarian teratoma. ( 30505981 )
2019
2
Cerebellar Differentiation in Ovarian Teratoma: A Report of 6 Cases. ( 29889717 )
2018
3
Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report. ( 29403279 )
2018
4
Immature ovarian teratoma with gliomatosis peritonei with adenocarcinomatous differentiation in one of the lymph node's metastasis. ( 29523036 )
2018
5
Histopathological characterization of the neuroglial tissue in ovarian teratoma associated with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. ( 30427104 )
2018
6
Ovarian Teratoma or Uterine Malformation? PET/MRI as a Novel Useful Tool in NMDAR Encephalitis. ( 30150449 )
2018
7
Ovarian teratoma associated Anti-N-methyl-D-aspartate receptor encephalitis: a difficult diagnosis with a favorable prognosis. ( 29780755 )
2018
8
General anesthesia with propofol for ovarian teratoma excision associated with anti-N-methyl-D-aspartate receptor encephalitis. ( 29457123 )
2018
9
Ovarian teratoma associated with anti-NMDA (N-methyl D-aspartate) receptor encephalitis. ( 29535092 )
2018
10
Hyperthyroidism in a complete molar pregnancy with a mature cystic ovarian teratoma. ( 30116304 )
2018
11
Novel compound heterozygous variants in the XPC gene identified in a Chinese xeroderma pigmentosum group C patient with ovarian teratoma. ( 29696685 )
2018
12
An unusual cause of renal colic: ovarian teratoma. ( 30088724 )
2018
13
Ovarian teratoma in children: a plea for collaborative clinical study. ( 30165903 )
2018
14
MR imaging of cystic ovarian teratoma with internal floating globules. ( 30220586 )
2018
15
Ovarian teratoma removed by laparoscopic ovariectomy in a dog. ( 30304893 )
2018
16
Ovarian teratoma: yet another cause of immune thrombocytopenia. ( 30323687 )
2018
17
Mismatch repair deficiency is implicated in carcinoma arising from ovarian teratoma. ( 30502217 )
2018
18
Radioactive iodine (131)I uptake in an ovarian teratoma. ( 28800880 )
2017
19
Ovarian teratoma: A case from 15th-18th century Lisbon, Portugal. ( 28888390 )
2017
20
A Rare Presentation of the Syndrome of Inappropriate Antidiuretic Hormone in a 12-year old Female as the Initial Presentation of an Immature Ovarian Teratoma. ( 28818586 )
2017
21
Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature. ( 28615984 )
2017
22
Anti-n-Methyl-d-Aspartate-Receptor (NMDAR) Encephalitis in Association with Ovarian Teratoma. ( 28884051 )
2017
23
Anti-N-methyl-D-aspartate-receptor encephalitis due ovarian teratoma. ( 28867338 )
2017
24
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2017
25
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1. ( 28719514 )
2017
26
Simultaneous Presentation of Wilms Tumor and Immature Ovarian Teratoma in Beckwith-Wiedemann Syndrome. ( 28692553 )
2017
27
Laparoscopic Excision of a Uterine Adenomatoid Tumor and a Coexisting Ovarian Teratoma: A Case Report and Literature Review. ( 28724848 )
2017
28
Immature Ovarian Teratoma: When to Give Adjuvant Therapy? ( 28859031 )
2017
29
Well-formed cerebellum and brainstem-like structures in a mature ovarian teratoma: Neuropathological observations. ( 28042664 )
2017
30
Ovarian Teratoma Associated with Coexisting anti-N-Methyl-D-Aspartate Receptor and Glial Fibrillary Acidic Protein Autoimmune Meningoencephalitis in an Adolescent Girl: A Case Report. ( 29294378 )
2017
31
Immature ovarian teratoma in two heifers. ( 29307128 )
2017
32
Lower abdominal gossypiboma mimics ovarian teratoma: a case report and review of the literature. ( 28061867 )
2017
33
Vascular Smooth Muscle Cell Maturation Stage and Ki-67 Index are Diagnostic Biomarkers for Pathologic Grade of Ovarian Teratoma. ( 28319573 )
2017
34
Absence of NMDA receptor antibodies in patients with ovarian teratoma without encephalitis. ( 28439526 )
2017
35
The use of human mature cystic ovarian teratoma as a model to study the development of human lymphatics. ( 28713613 )
2017
36
Case 1: Acute Psychosis in a 16-year-old Girl with an Ovarian Teratoma. ( 28972051 )
2017
37
Repeated pregnancy with concomitant presence of ovarian teratoma: A case report and literature review. ( 29037561 )
2017
38
Recurrence of immature ovarian teratoma as malignant follicular carcinoma with liver and peritoneal metastasis 22 years after completion of initial treatment. ( 29066646 )
2017
39
Giant ovarian teratoma: an important differential diagnosis of pelvic masses in children. ( 29085173 )
2017
40
Tuba-ovarian auto-amputation caused by ovarian teratoma in an adolescent girl. ( 29168372 )
2017
41
Vedolizumab as a Potential Culprit in the Development of Ovarian Teratoma? ( 29606936 )
2017
42
Repeated misdiagnosis of a relapsed atypical anti-NMDA receptor encephalitis without an associated ovarian teratoma. ( 27899309 )
2017
43
'Sack of marbles' in mature cystic ovarian teratoma. ( 28138731 )
2017
44
Hypoxia induces autophagy in PA-l ovarian teratoma cells and resistance to growth inhibition and apoptosis by chemotherapeutic agent cis-diamminedichloroplatinum. ( 29953795 )
2017
45
Prostate-Type Adenocarcinoma in Mature Cystic Ovarian Teratoma. ( 26352547 )
2016
46
Benign enhancing components of mature ovarian teratoma: magnetic resonance imaging features and pathologic correlation. ( 27568071 )
2016
47
Ovarian teratoma development after anti-NMDA receptor encephalitis treatment. ( 28040316 )
2016
48
An Uncommon Case of Adolescent Ovarian Teratoma Incarcerated in Inguinal Hernia. ( 27525145 )
2016
49
Ovarian teratoma in an adult female Zoogoneticus tequila (Webb & Miller 1998): histological and immunohistochemical features. ( 27592861 )
2016
50
Paraneoplastic syndromes revealing ovarian teratoma in young and menopausal women: report of two cases. ( 27795759 )
2016

Variations for Ovarian Germ Cell Teratoma

Expression for Ovarian Germ Cell Teratoma

Search GEO for disease gene expression data for Ovarian Germ Cell Teratoma.

Pathways for Ovarian Germ Cell Teratoma

Pathways related to Ovarian Germ Cell Teratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.07 NRAS RET
2 10.77 NRAS RET
3 10.3 NRAS RET

GO Terms for Ovarian Germ Cell Teratoma

Biological processes related to Ovarian Germ Cell Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 8.62 NKX2-1 TG

Sources for Ovarian Germ Cell Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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