MCID: OVR009
MIFTS: 30

Ovarian Gonadoblastoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Gonadoblastoma

MalaCards integrated aliases for Ovarian Gonadoblastoma:

Name: Ovarian Gonadoblastoma 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3578
NCIt 50 C39985
SNOMED-CT 67 716594002
UMLS 70 C1518716

Summaries for Ovarian Gonadoblastoma

Disease Ontology : 12 An ovarian benign neoplasm that is has material basis in a mixture of gonadal elements.

MalaCards based summary : Ovarian Gonadoblastoma is related to dysgerminoma and mixed germ cell tumor. An important gene associated with Ovarian Gonadoblastoma is DMRT2 (Doublesex And Mab-3 Related Transcription Factor 2), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, ovary and testis, and related phenotypes are embryo and endocrine/exocrine gland

Related Diseases for Ovarian Gonadoblastoma

Diseases related to Ovarian Gonadoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 dysgerminoma 30.6 WT1 KIT AFP
2 mixed germ cell tumor 30.3 KIT AFP
3 mixed gonadal dysgenesis 30.3 SOX9 KIT
4 endodermal sinus tumor 30.1 TNFRSF8 GPC3 AFP
5 gonadoblastoma 29.6 WT1 SOX9 POU5F1 NR0B1 KIT DMRT1
6 germ cell cancer 29.5 POU5F1 KIT DMRT1 AFP
7 embryonal carcinoma 29.2 TNFRSF8 POU5F1 KIT AFP
8 teratoma 28.9 POU5F1 KIT GPC3 DMRT1 CALB2 AFP
9 gonadal dysgenesis 28.7 WT1 SOX9 POU5F1 NR0B1 KIT DMRT2
10 amelogenesis imperfecta, type ia 10.3 KIT AMELX
11 ovarian fibrothecoma 10.3 KIT CALB2
12 mixed germ cell-sex cord neoplasm 10.3 DMRT1 CALB2
13 benign fibrous mesothelioma 10.3 KIT CALB2
14 liver fibroma 10.3 KIT CALB2
15 mediastinum seminoma 10.3 KIT AFP
16 extragonadal seminoma 10.3 KIT AFP
17 pineal region teratoma 10.2 KIT AFP
18 gallbladder leiomyosarcoma 10.2 KIT AFP
19 mucinous stomach adenocarcinoma 10.2 KIT CALB2
20 liver leiomyoma 10.2 KIT AFP
21 esophageal adenoid cystic carcinoma 10.2 KIT AFP
22 embryonal sarcoma 10.2 KIT GPC3
23 thymus clear cell carcinoma 10.2 KIT CALB2
24 lung leiomyosarcoma 10.2 KIT CALB2
25 endometrial small cell carcinoma 10.2 KIT AFP
26 ovarian serous adenofibroma 10.2 WNT4 CALB2
27 ovarian serous cystadenofibroma 10.2 WNT4 CALB2
28 pediatric germ cell cancer 10.2 DMRT1 AFP
29 rete testis neoplasm 10.2 CALB2 AFP
30 rete testis adenocarcinoma 10.2 CALB2 AFP
31 adult type testicular granulosa cell tumor 10.2 CALB2 AFP
32 sclerosing hepatic carcinoma 10.2 GPC3 AFP
33 dermoid cyst of ovary 10.2 CALB2 AFP
34 heart cancer 10.2 KIT CALB2
35 spermatocele 10.2 CALB2 AFP
36 nonsyndromic disorders of testicular development 10.2 WNT4 NR0B1 DMRT1
37 ovarian germ cell teratoma 10.2 CALB2 AFP
38 pleural lipoma 10.2 TNFRSF8 KIT
39 45,x/46,xy mixed gonadal dysgenesis 10.2 WNT4 NR0B1 DMRT1
40 uterus leiomyosarcoma 10.1 TNFRSF8 KIT
41 gigantism 10.1 PRL GPC3
42 conventional fibrosarcoma 10.1 TNFRSF8 KIT
43 ovarian solid teratoma 10.1 TNFRSF8 AFP
44 uterine corpus sarcoma 10.1 TNFRSF8 KIT
45 small intestinal sarcoma 10.1 WT1 KIT
46 colon leiomyosarcoma 10.1 WT1 KIT
47 intermediate malignant teratoma 10.1 TNFRSF8 AFP
48 testicular germ cell tumor 10.1 KIT DMRT1 AFP
49 testicular germ cell cancer 10.1 KIT DMRT1 AFP
50 testicular infarct 10.1 TNFRSF8 AFP

Graphical network of the top 20 diseases related to Ovarian Gonadoblastoma:



Diseases related to Ovarian Gonadoblastoma

Symptoms & Phenotypes for Ovarian Gonadoblastoma

MGI Mouse Phenotypes related to Ovarian Gonadoblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.7 DMRT2 GPC3 KIT POU5F1 SOX9 WNT4
2 endocrine/exocrine gland MP:0005379 9.65 AFP DMRT1 KIT NR0B1 POU5F1 PRL
3 reproductive system MP:0005389 9.36 AFP DMRT1 DMRT2 GPC3 KIT NR0B1

Drugs & Therapeutics for Ovarian Gonadoblastoma

Search Clinical Trials , NIH Clinical Center for Ovarian Gonadoblastoma

Genetic Tests for Ovarian Gonadoblastoma

Anatomical Context for Ovarian Gonadoblastoma

MalaCards organs/tissues related to Ovarian Gonadoblastoma:

40
Liver, Ovary, Testis, Bone, Thymus, Brain, Heart

Publications for Ovarian Gonadoblastoma

Articles related to Ovarian Gonadoblastoma:

(show all 18)
# Title Authors PMID Year
1
Usefulness of imprint cytology of gonadoblastoma with dysgerminoma in a patient with Turner syndrome and a Y chromosome: A case report and literature review. 61
31336030 2019
2
Canine ovarian gonadoblastoma with dysgerminoma overgrowth: a case study and literature review. 61
31547830 2019
3
Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma. 61
27411466 2016
4
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. 61
24179931 2013
5
Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature. 61
21879333 2012
6
Ovarian gonadoblastoma with dysgerminoma in a woman with 46XX karyotype. 61
21355962 2011
7
Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype. 61
20598061 2010
8
Left ovarian gonadoblastoma with yolk sac tumor in a young woman. 61
20551554 2010
9
[Clinicopathologic analysis of ovarian gonadoblastoma]. 61
19781351 2009
10
Breast cancer, ovarian gonadoblastoma and cervical cancer in a patient with Peutz-Jeghers Syndrome. 61
18193442 2008
11
Peutz-Jeghers syndrome combined with breast cancer, cervical carcinoma and ovarian gonadoblastoma: a case report. 61
17415855 2004
12
Laparoscopic management of antenatally-diagnosed abdominal cysts in newborns. 61
15259587 2004
13
Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46, XX karyotype and successful pregnancies. 61
10849320 2000
14
Unique combination of an ovarian gonadoblastoma, dysgerminoma, and mucinous cystadenoma in a patient with Turner's syndrome: a cytogenetic and molecular analysis. 61
7928059 1994
15
Ovarian gonadoblastoma with dysgerminoma in a woman with two normal children. 61
2744756 1989
16
[Ovarian gonadoblastoma, hemi-atrophy and balanced autosomal translocation (author's transl)]. 61
7212786 1981
17
Ataxia-telangiectasia with ovarian gonadoblastoma and contralateral dysgerminoma. 61
1192368 1975
18
Feminization in gonadal dysgenesis associated with ovarian gonadoblastoma. 61
1153143 1975

Variations for Ovarian Gonadoblastoma

Expression for Ovarian Gonadoblastoma

Search GEO for disease gene expression data for Ovarian Gonadoblastoma.

Pathways for Ovarian Gonadoblastoma

Pathways related to Ovarian Gonadoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 WNT4 SOX9 KIT
2 11.05 WT1 SOX9 POU5F1 AFP

GO Terms for Ovarian Gonadoblastoma

Cellular components related to Ovarian Gonadoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.43 WT1 SOX9 POU5F1 NR0B1 DMRT2 DMRT1
2 endoplasmic reticulum lumen GO:0005788 8.92 WNT4 GPC3 AMELX AFP

Biological processes related to Ovarian Gonadoblastoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10 WT1 SOX9 POU5F1 NR0B1 DMRT1
2 spermatogenesis GO:0007283 9.91 SOX9 NR0B1 KIT DMRT1
3 negative regulation of cell proliferation GO:0008285 9.91 WT1 TNFRSF8 SOX9 GPC3
4 cellular protein metabolic process GO:0044267 9.83 PRL GPC3 AMELX AFP
5 kidney development GO:0001822 9.77 WT1 WNT4 GPC3
6 somatic stem cell population maintenance GO:0035019 9.65 SOX9 POU5F1 KIT
7 epithelial to mesenchymal transition GO:0001837 9.63 WNT4 SOX9 AMELX
8 positive regulation of collagen biosynthetic process GO:0032967 9.62 WNT4 AMELX
9 negative regulation of pri-miRNA transcription by RNA polymerase II GO:1902894 9.58 SOX9 POU5F1
10 oocyte development GO:0048599 9.58 WNT4 DMRT1
11 sex differentiation GO:0007548 9.58 WNT4 DMRT2 DMRT1
12 gonad development GO:0008406 9.57 WT1 NR0B1
13 mesenchymal to epithelial transition GO:0060231 9.56 WT1 WNT4
14 Sertoli cell development GO:0060009 9.55 SOX9 DMRT1
15 sex determination GO:0007530 9.54 WT1 NR0B1
16 adrenal gland development GO:0030325 9.54 WT1 WNT4 NR0B1
17 negative regulation of steroid biosynthetic process GO:0010894 9.51 WNT4 NR0B1
18 male sex determination GO:0030238 9.5 SOX9 NR0B1 DMRT1
19 germ cell migration GO:0008354 9.49 KIT DMRT1
20 renal vesicle induction GO:0072034 9.43 WNT4 SOX9
21 positive regulation of male gonad development GO:2000020 9.43 WT1 SOX9 DMRT1
22 Sertoli cell differentiation GO:0060008 9.33 SOX9 NR0B1 DMRT1
23 branching involved in ureteric bud morphogenesis GO:0001658 9.26 WT1 WNT4 SOX9 GPC3
24 male gonad development GO:0008584 9.1 WT1 WNT4 SOX9 NR0B1 KIT DMRT1

Molecular functions related to Ovarian Gonadoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.56 WT1 SOX9 DMRT2 DMRT1
2 DNA-binding transcription factor activity GO:0003700 9.55 WT1 SOX9 POU5F1 DMRT2 DMRT1
3 proximal promoter sequence-specific DNA binding GO:0000987 9.13 SOX9 POU5F1 DMRT1
4 sequence-specific DNA binding GO:0043565 9.02 WT1 SOX9 POU5F1 DMRT2 DMRT1

Sources for Ovarian Gonadoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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