MCID: OVR005
MIFTS: 28

Ovarian Large-Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Reproductive diseases

Aliases & Classifications for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Ovarian Large-Cell Neuroendocrine Carcinoma:

Name: Ovarian Large-Cell Neuroendocrine Carcinoma 12 15
Non-Small-Cell Type Neuroendocrine Carcinoma of Ovary 12
Ovarian Large Cell Neuroendocrine Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4555
NCIt 50 C5238
UMLS 70 C1335174

Summaries for Ovarian Large-Cell Neuroendocrine Carcinoma

Disease Ontology : 12 An ovarian carcinoma that is characterized by large pleiomorphic cells with large round or oval nuclei, presence of mitoses and staining for neuroendocrine (NE) markers and has material basis in neuroendocrine cells.

MalaCards based summary : Ovarian Large-Cell Neuroendocrine Carcinoma, also known as non-small-cell type neuroendocrine carcinoma of ovary, is related to appendix adenocarcinoma and neuroendocrine carcinoma. An important gene associated with Ovarian Large-Cell Neuroendocrine Carcinoma is CHGA (Chromogranin A). Affiliated tissues include ovary and cervix.

Related Diseases for Ovarian Large-Cell Neuroendocrine Carcinoma

Diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.0 SYP KRT7 KRT20 CHGA
2 neuroendocrine carcinoma 29.9 SYP NCAM1 KRT7 KRT20 ENO2 CHGA
3 large cell neuroendocrine carcinoma 29.9 SYP NCAM1 KRT7 KRT20 ENO2 CHGA
4 teratoma 29.1 SYP KRT7 KRT20 ENO2 CHGA AMH
5 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
6 acinar cell cystadenocarcinoma 10.3 SYP CHGA
7 vulvar eccrine porocarcinoma 10.3 SYP CHGA
8 gastrointestinal neuroendocrine benign tumor 10.3 SYP CHGA
9 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
10 duodenal benign neoplasm 10.3 SYP CHGA
11 breast papillary carcinoma 10.3 SYP CHGA
12 gastric neuroendocrine neoplasm 10.3 SYP CHGA
13 lung combined type small cell carcinoma 10.3 SYP NCAM1
14 pancreatic gastrinoma 10.3 SYP CHGA
15 hypoganglionosis 10.3 SYP NCAM1
16 glomangiosarcoma 10.3 SYP NCAM1
17 ovary neuroendocrine neoplasm 10.3 SYP KRT7
18 mucinous adenofibroma 10.3 SYP KRT7
19 binswanger's disease 10.3 SYP CHGA
20 pancreatic acinar cell adenocarcinoma 10.3 SYP CHGA
21 extra-adrenal pheochromocytoma 10.3 SYP CHGA
22 appendiceal neoplasm 10.3 KRT7 CHGA
23 rectum neuroendocrine neoplasm 10.3 SYP KRT7
24 papillary squamous carcinoma 10.3 SYP KRT7
25 parachordoma 10.3 KRT7 CHGA
26 prostate stromal sarcoma 10.3 SYP NCAM1
27 ureteral benign neoplasm 10.3 SYP KRT7
28 ovarian germ cell teratoma 10.3 SYP KRT7
29 adrenal medulla cancer 10.3 SYP CHGA
30 eyelid benign neoplasm 10.3 KRT20 CHGA
31 clear cell meningioma 10.3 SYP CHGA
32 orbital cellulitis 10.3 NCAM1 KRT7
33 villous adenoma 10.3 KRT7 KRT20
34 dacryocystocele 10.3 NCAM1 KRT7
35 keratinizing squamous cell carcinoma 10.3 SYP KRT7
36 chronic inflammation of lacrimal passage 10.3 NCAM1 KRT7
37 papillary adenoma 10.2 SYP KRT7
38 pancreatoblastoma 10.2 SYP CHGA
39 chordoid glioma 10.2 SYP KRT7
40 nasal cavity adenocarcinoma 10.2 SYP KRT7
41 rare tumor 10.2
42 vaginal glandular tumor 10.2 ENO2 CHGA
43 urethral villous adenoma 10.2 KRT7 KRT20
44 ovarian germ cell cancer 10.2 SYP KRT7
45 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
46 gastric gastrinoma 10.2 ENO2 CHGA
47 atrophic vulva 10.2 KRT7 KRT20
48 urinary bladder villous adenoma 10.2 KRT7 KRT20
49 optic nerve astrocytoma 10.2 SYP ENO2
50 cerebral neuroblastoma 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma:



Diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Ovarian Large-Cell Neuroendocrine Carcinoma

Drugs & Therapeutics for Ovarian Large-Cell Neuroendocrine Carcinoma

Search Clinical Trials , NIH Clinical Center for Ovarian Large-Cell Neuroendocrine Carcinoma

Genetic Tests for Ovarian Large-Cell Neuroendocrine Carcinoma

Anatomical Context for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Ovarian Large-Cell Neuroendocrine Carcinoma:

40
Ovary, Cervix

Publications for Ovarian Large-Cell Neuroendocrine Carcinoma

Articles related to Ovarian Large-Cell Neuroendocrine Carcinoma:

# Title Authors PMID Year
1
Primary pure large cell neuroendocrine carcinoma of the ovary: A rare case report and review of literature. 61
33285672 2020
2
Serous Tubal Intraepithelial Carcinoma-Like and Pagetoid Tubal Metastasis of an Ovarian Large Cell Neuroendocrine Carcinoma: Peculiar Metastatic Growth Patterns of a Rare Tumor. 61
33164612 2020
3
Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature. 61
31345245 2019
4
Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. 61
28566585 2017
5
Pure Large Cell Neuroendocrine Carcinoma of the Ovary with Metastasis to Cervix: A Rare Case Report and Review of Literature. 61
27790443 2016
6
Ovarian large cell neuroendocrine carcinoma in the youngest woman. 61
27172753 2016
7
Clinical features of ovarian large-cell neuroendocrine carcinoma: Four case reports and review of the literature. 61
22977625 2011
8
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. 61
19577382 2009
9
Ovarian large cell neuroendocrine carcinoma. 61
18840191 2008
10
Large cell neuroendocrine carcinoma of the ovary. 61
17295684 2007

Variations for Ovarian Large-Cell Neuroendocrine Carcinoma

Cosmic variations for Ovarian Large-Cell Neuroendocrine Carcinoma:

9 (show all 24)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM107914383 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 3
2 COSM98179101 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 3
3 COSM88669027 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 3
4 COSM90500842 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 3
5 COSM104680590 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 3
6 COSM122278092 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.121G>T p.V41L 17:7675095-7675095 3
7 COSM144658526 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.400G>T p.V134L 17:7675095-7675095 3
8 COSM121884280 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.121G>T p.V41L 17:7675095-7675095 3
9 COSM105627506 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
10 COSM143949547 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.40G>T p.V14L 17:7675095-7675095 3
11 COSM93190437 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
12 COSM112259869 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
13 COSM144315678 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.400G>T p.V134L 17:7675095-7675095 3
14 COSM143162405 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.40G>T p.V14L 17:7675095-7675095 3
15 COSM144091761 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.40G>T p.V14L 17:7675095-7675095 3
16 COSM122740436 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.121G>T p.V41L 17:7675095-7675095 3
17 COSM144020050 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.484G>T p.V162L 17:7675095-7675095 3
18 COSM142566746 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.400G>T p.V134L 17:7675095-7675095 3
19 COSM142842406 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
20 COSM87906185 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
21 COSM145024750 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.400G>T p.V134L 17:7675095-7675095 3
22 COSM106059804 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
23 COSM111765575 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 3
24 COSM143377849 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.400G>T p.V134L 17:7675095-7675095 3

Expression for Ovarian Large-Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Ovarian Large-Cell Neuroendocrine Carcinoma.

Pathways for Ovarian Large-Cell Neuroendocrine Carcinoma

GO Terms for Ovarian Large-Cell Neuroendocrine Carcinoma

Biological processes related to Ovarian Large-Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 urogenital system development GO:0001655 9.37 PAX8 AMH
2 gonad development GO:0008406 9.32 WT1 AMH
3 cellular response to gonadotropin stimulus GO:0071371 9.26 WT1 PAX8
4 sex determination GO:0007530 9.16 WT1 AMH
5 metanephric S-shaped body morphogenesis GO:0072284 8.96 WT1 PAX8
6 metanephric epithelium development GO:0072207 8.62 WT1 PAX8

Sources for Ovarian Large-Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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