MCID: OVR005
MIFTS: 22

Ovarian Large-Cell Neuroendocrine Carcinoma

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Ovarian Large-Cell Neuroendocrine Carcinoma:

Name: Ovarian Large-Cell Neuroendocrine Carcinoma 12 15
Non-Small-Cell Type Neuroendocrine Carcinoma of Ovary 12
Ovarian Large Cell Neuroendocrine Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4555
NCIt 50 C5238
UMLS 73 C1335174

Summaries for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards based summary : Ovarian Large-Cell Neuroendocrine Carcinoma, also known as non-small-cell type neuroendocrine carcinoma of ovary, is related to teratoma and mucinous adenocarcinoma. An important gene associated with Ovarian Large-Cell Neuroendocrine Carcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary.

Related Diseases for Ovarian Large-Cell Neuroendocrine Carcinoma

Diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 teratoma 29.9 KRT7 SYP
2 mucinous adenocarcinoma 29.6 KRT20 KRT7
3 large cell neuroendocrine carcinoma 27.6 CHGA KRT20 KRT7 NCAM1 SYP
4 ureter small cell carcinoma 10.4 CHGA SYP
5 urinary bladder small cell neuroendocrine carcinoma 10.4 CHGA SYP
6 auditory system cancer 10.4 CHGA SYP
7 acinar cell cystadenocarcinoma 10.4 CHGA SYP
8 peritoneal serous adenocarcinoma 10.4 CHGA SYP
9 cellular ependymoma 10.4 CHGA SYP
10 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
11 gastrointestinal neuroendocrine tumor 10.4 CHGA SYP
12 pulmonary large cell neuroendocrine carcinoma 10.4 CHGA SYP
13 atypical follicular adenoma 10.4 CHGA SYP
14 chordoid meningioma 10.4 CHGA SYP
15 olfactory nerve neoplasm 10.4 CHGA SYP
16 cauda equina neoplasm 10.4 CHGA SYP
17 nodular ganglioneuroblastoma 10.4 CHGA SYP
18 pineocytoma 10.4 CHGA SYP
19 respiratory system benign neoplasm 10.4 CHGA SYP
20 pancreatoblastoma 10.4 CHGA SYP
21 carcinoid tumors, intestinal 10.4 CHGA SYP
22 pulmonary blastoma 10.4 CHGA SYP
23 ureter, cancer of 10.4 CHGA SYP
24 ovary neuroendocrine neoplasm 10.4 KRT7 SYP
25 tanycytic ependymoma 10.4 CHGA SYP
26 papillary ependymoma 10.4 CHGA SYP
27 mucinous adenofibroma 10.4 KRT7 SYP
28 non-functioning pancreatic endocrine tumor 10.4 CHGA SYP
29 pleomorphic xanthoastrocytoma 10.3 CHGA SYP
30 middle ear adenoma 10.3 KRT7 SYP
31 central neurocytoma 10.3 CHGA SYP
32 pancreatic cystadenocarcinoma 10.3 CHGA SYP
33 binswanger's disease 10.3 CHGA SYP
34 carcinoid syndrome 10.3 CHGA SYP
35 cranial nerve malignant neoplasm 10.3 CHGA SYP
36 endodermal sinus tumor 10.3 CHGA KRT7
37 olfactory neuroblastoma 10.3 CHGA SYP
38 cerebellar liponeurocytoma 10.3 CHGA SYP
39 mucinous ovarian cystadenoma 10.3 KRT7 SYP
40 seminal vesicle tumor 10.3 KRT7 SYP
41 fibrolamellar carcinoma 10.3 KRT7 SYP
42 atypical choroid plexus papilloma 10.3 KRT7 SYP
43 breast papillary carcinoma 10.3 CHGA SYP
44 acinar cell carcinoma 10.3 CHGA KRT7
45 mixed cell type cancer 10.3 KRT7 SYP
46 lung combined type small cell carcinoma 10.2 NCAM1 SYP
47 basaloid squamous cell carcinoma 10.2 KRT7 SYP
48 extrahepatic bile duct adenocarcinoma 10.2 NCAM1 SYP
49 orbital cancer 10.2 NCAM1 SYP
50 renal adenoma 10.2 KRT7 NCAM1

Graphical network of the top 20 diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma:



Diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Ovarian Large-Cell Neuroendocrine Carcinoma

Drugs & Therapeutics for Ovarian Large-Cell Neuroendocrine Carcinoma

Search Clinical Trials , NIH Clinical Center for Ovarian Large-Cell Neuroendocrine Carcinoma

Genetic Tests for Ovarian Large-Cell Neuroendocrine Carcinoma

Anatomical Context for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Ovarian Large-Cell Neuroendocrine Carcinoma:

41
Ovary

Publications for Ovarian Large-Cell Neuroendocrine Carcinoma

Articles related to Ovarian Large-Cell Neuroendocrine Carcinoma:

# Title Authors Year
1
Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. ( 28566585 )
2017
2
Ovarian large cell neuroendocrine carcinoma in the youngest woman. ( 27172753 )
2016
3
Clinical features of ovarian large-cell neuroendocrine carcinoma: Four case reports and review of the literature. ( 22977625 )
2011
4
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. ( 19577382 )
2009
5
Ovarian large cell neuroendocrine carcinoma. ( 18840191 )
2008

Variations for Ovarian Large-Cell Neuroendocrine Carcinoma

Cosmic variations for Ovarian Large-Cell Neuroendocrine Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6951705 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 8
2 COSM43559 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 8
3 COSM99640 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.238G>T p.V80L 17:7675095-7675095 8
4 COSM3723937 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 8
5 COSM3723936 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 8
6 COSM99638 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 8
7 COSM99639 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.121G>T p.V41L 17:7675095-7675095 8
8 COSM99641 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 8
9 COSM6951706 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 8

Expression for Ovarian Large-Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Ovarian Large-Cell Neuroendocrine Carcinoma.

Pathways for Ovarian Large-Cell Neuroendocrine Carcinoma

Pathways related to Ovarian Large-Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 NCAM1 SYP

GO Terms for Ovarian Large-Cell Neuroendocrine Carcinoma

Biological processes related to Ovarian Large-Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 8.62 KRT20 KRT7

Sources for Ovarian Large-Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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