MCID: OVR005
MIFTS: 21

Ovarian Large-Cell Neuroendocrine Carcinoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Reproductive diseases

Aliases & Classifications for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards integrated aliases for Ovarian Large-Cell Neuroendocrine Carcinoma:

Name: Ovarian Large-Cell Neuroendocrine Carcinoma 12 15
Non-Small-Cell Type Neuroendocrine Carcinoma of Ovary 12
Ovarian Large Cell Neuroendocrine Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4555
NCIt 51 C5238
UMLS 74 C1335174

Summaries for Ovarian Large-Cell Neuroendocrine Carcinoma

Disease Ontology : 12 An ovarian carcinoma that is characterized by large pleiomorphic cells with large round or oval nuclei, presence of mitoses and staining for neuroendocrine (NE) markers and has_material_basis in neuroendocrine cells.

MalaCards based summary : Ovarian Large-Cell Neuroendocrine Carcinoma, also known as non-small-cell type neuroendocrine carcinoma of ovary, is related to large cell neuroendocrine carcinoma and neuroendocrine carcinoma. An important gene associated with Ovarian Large-Cell Neuroendocrine Carcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary.

Related Diseases for Ovarian Large-Cell Neuroendocrine Carcinoma

Diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 large cell neuroendocrine carcinoma 29.6 CHGA KRT20 NCAM1 SYP
2 neuroendocrine carcinoma 10.4
3 vaginal benign neoplasm 10.1 CHGA KRT20
4 vaginal adenoma 10.1 CHGA KRT20
5 vaginal tubulovillous adenoma 10.1 CHGA KRT20
6 fibroepithelial basal cell carcinoma 10.1 CHGA KRT20
7 goblet cell carcinoid 10.1 CHGA KRT20
8 ureter small cell carcinoma 10.1 CHGA SYP
9 urinary bladder small cell neuroendocrine carcinoma 10.1 CHGA SYP
10 dermoid cyst 10.1 CHGA KRT20
11 auditory system cancer 10.1 CHGA SYP
12 acinar cell cystadenocarcinoma 10.1 CHGA SYP
13 peritoneal serous adenocarcinoma 10.1 CHGA SYP
14 cellular ependymoma 10.1 CHGA SYP
15 primary hepatic neuroendocrine carcinoma 10.1 CHGA SYP
16 gastrointestinal neuroendocrine tumor 10.1 CHGA SYP
17 pulmonary large cell neuroendocrine carcinoma 10.1 CHGA SYP
18 atypical follicular adenoma 10.1 CHGA SYP
19 chordoid meningioma 10.1 CHGA SYP
20 olfactory groove meningioma 10.1 CHGA SYP
21 adenocarcinoma 10.1
22 mucinous adenocarcinoma 10.1
23 teratoma 10.1
24 cauda equina neoplasm 10.1 CHGA SYP
25 olfactory nerve neoplasm 10.1 CHGA SYP
26 autonomic nervous system benign neoplasm 10.1 CHGA SYP
27 nodular ganglioneuroblastoma 10.1 CHGA SYP
28 medulloepithelioma 10.1 KRT20 SYP
29 glycogen-rich clear cell breast carcinoma 10.0 KRT20 SYP
30 pulmonary sclerosing hemangioma 10.0 CHGA SYP
31 sclerosing hemangioma 10.0 CHGA SYP
32 hemangioma 10.0 CHGA SYP
33 pineocytoma 10.0 CHGA SYP
34 pancreatoblastoma 10.0 CHGA SYP
35 carcinoid tumors, intestinal 10.0 CHGA SYP
36 cecum adenocarcinoma 10.0 CHGA KRT20
37 respiratory system benign neoplasm 10.0 CHGA SYP
38 anterior cranial fossa meningioma 10.0 CHGA SYP
39 pulmonary blastoma 10.0 CHGA SYP
40 pleomorphic xanthoastrocytoma 10.0 CHGA SYP
41 tanycytic ependymoma 10.0 CHGA SYP
42 papillary ependymoma 10.0 CHGA SYP
43 non-functioning pancreatic endocrine tumor 10.0 CHGA SYP
44 signet ring cell adenocarcinoma 10.0 CHGA KRT20
45 ovarian mucinous neoplasm 10.0 KRT20 SYP
46 central neurocytoma 10.0 CHGA SYP
47 thymus lipoma 10.0 KRT20 SYP
48 binswanger's disease 10.0 CHGA SYP
49 carcinoid syndrome 10.0 CHGA SYP
50 immune system organ benign neoplasm 10.0 KRT20 SYP

Graphical network of the top 20 diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma:



Diseases related to Ovarian Large-Cell Neuroendocrine Carcinoma

Symptoms & Phenotypes for Ovarian Large-Cell Neuroendocrine Carcinoma

Drugs & Therapeutics for Ovarian Large-Cell Neuroendocrine Carcinoma

Search Clinical Trials , NIH Clinical Center for Ovarian Large-Cell Neuroendocrine Carcinoma

Genetic Tests for Ovarian Large-Cell Neuroendocrine Carcinoma

Anatomical Context for Ovarian Large-Cell Neuroendocrine Carcinoma

MalaCards organs/tissues related to Ovarian Large-Cell Neuroendocrine Carcinoma:

42
Ovary

Publications for Ovarian Large-Cell Neuroendocrine Carcinoma

Articles related to Ovarian Large-Cell Neuroendocrine Carcinoma:

# Title Authors Year
1
Ovarian Large Cell Neuroendocrine Carcinoma Associated with Serous Carcinoma: Correlation of Pathology with MR Imaging. ( 28566585 )
2017
2
Ovarian large cell neuroendocrine carcinoma in the youngest woman. ( 27172753 )
2016
3
Clinical features of ovarian large-cell neuroendocrine carcinoma: Four case reports and review of the literature. ( 22977625 )
2011
4
Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature. ( 19577382 )
2009
5
Ovarian large cell neuroendocrine carcinoma. ( 18840191 )
2008

Variations for Ovarian Large-Cell Neuroendocrine Carcinoma

Cosmic variations for Ovarian Large-Cell Neuroendocrine Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6951705 TP63 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 0
2 COSM43559 TP53 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 0
3 COSM99640 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.238G>T p.V80L 17:7675095-7675095 0
4 COSM3723937 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 0
5 COSM3723936 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 0
6 COSM99638 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 0
7 COSM99639 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.121G>T p.V41L 17:7675095-7675095 0
8 COSM99641 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.517G>T p.V173L 17:7675095-7675095 0
9 COSM6951706 ovary,NS,carcinoma,large cell neuroendocrine carcinoma c.281A>T p.D94V 3:189738731-189738731 0

Expression for Ovarian Large-Cell Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Ovarian Large-Cell Neuroendocrine Carcinoma.

Pathways for Ovarian Large-Cell Neuroendocrine Carcinoma

Pathways related to Ovarian Large-Cell Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 NCAM1 SYP

GO Terms for Ovarian Large-Cell Neuroendocrine Carcinoma

Sources for Ovarian Large-Cell Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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