MCID: OVR104
MIFTS: 31

Ovarian Melanoma

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Ovarian Melanoma

MalaCards integrated aliases for Ovarian Melanoma:

Name: Ovarian Melanoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050928

Summaries for Ovarian Melanoma

Disease Ontology : 12 An ovarian cancer that has material basis in melanoctyes.

MalaCards based summary : Ovarian Melanoma is related to melanoma and senile angioma. An important gene associated with Ovarian Melanoma is MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Melanoma

Diseases related to Ovarian Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 melanoma 29.2 MAP2K1 MLANA NRAS PTEN
2 senile angioma 10.5 KIT MAP2K1
3 malignant spindle cell melanoma 10.5 KIT NRAS
4 giant congenital nevus 10.4 HRAS NRAS
5 mixed type thymoma 10.4 KIT PTEN
6 benign struma ovarii 10.4 HRAS NRAS
7 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS NRAS
8 malignant conjunctival melanoma 10.4 HRAS NRAS
9 melanomatosis 10.4 HRAS NRAS
10 marcus gunn phenomenon 10.4 HRAS NRAS
11 malignant struma ovarii 10.4 HRAS NRAS
12 clivus chordoma 10.4 HRAS PTEN
13 thymoma, familial 10.4 HRAS KIT
14 mucosal melanoma 10.3 KIT NRAS
15 ovarian fibrothecoma 10.3 CALB2 KIT
16 myelodysplastic myeloproliferative cancer 10.3 HRAS NRAS
17 congenital mesoblastic nephroma 10.3 KIT NRAS
18 meningeal melanomatosis 10.3 HRAS NRAS
19 nevus, epidermal 10.3 HRAS NRAS
20 aggressive digital papillary adenocarcinoma 10.3 HRAS KIT
21 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS
22 testicular granulosa cell tumor 10.3 MLANA SMARCA4
23 malignant leydig cell tumor 10.3 CALB2 KIT
24 juvenile type testicular granulosa cell tumor 10.3 MLANA SMARCA4
25 rete testis adenocarcinoma 10.3 CALB2 KIT
26 melanotic neurilemmoma 10.2 MLANA PTEN
27 neurogenic bowel 10.2 CALB2 KIT
28 lung adenoid cystic carcinoma 10.2 HRAS KIT
29 malignant anus melanoma 10.2 KIT MLANA
30 liver angiosarcoma 10.2 HRAS NRAS
31 pulmonic stenosis 10.2 HRAS MAP2K1
32 rete testis neoplasm 10.2 CALB2 KIT
33 mixed cell type cancer 10.2 HRAS KIT
34 breast angiosarcoma 10.2 KIT MLANA
35 costello syndrome 10.1 HRAS MAP2K1
36 undifferentiated pleomorphic sarcoma 10.1 KIT MLANA
37 meningeal melanocytoma 10.1 MLANA NRAS
38 functional colonic disease 10.1 CALB2 KIT
39 dysgerminoma of ovary 10.1 CALB2 KIT
40 acneiform dermatitis 10.1 HRAS MAP2K1 NRAS
41 small cell carcinoma 10.1 KIT PTEN SMARCA4
42 acral lentiginous melanoma 10.0 KIT NRAS PTEN
43 bladder urothelial carcinoma 10.0 HRAS MAP2K1 NRAS
44 noonan syndrome 1 10.0 HRAS MAP2K1 NRAS
45 pancreatic mucinous cystadenoma 10.0 CALB2 HRAS
46 deep leiomyoma 10.0 CALD1 KIT
47 melanoma, cutaneous malignant 1 10.0 HRAS NRAS PTEN
48 thyroid cancer, nonmedullary, 2 9.9 HRAS NRAS PTEN
49 colonic pseudo-obstruction 9.9 CALB2 KIT
50 core binding factor acute myeloid leukemia 9.9 HRAS KIT NRAS

Graphical network of the top 20 diseases related to Ovarian Melanoma:



Diseases related to Ovarian Melanoma

Symptoms & Phenotypes for Ovarian Melanoma

GenomeRNAi Phenotypes related to Ovarian Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.28 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.28 NRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.28 HRAS NRAS SMARCA4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.28 HRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.28 NRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.28 HRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.28 HRAS

MGI Mouse Phenotypes related to Ovarian Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 PTEN KIT SMARCA4 MAP2K1 NRAS HRAS
2 digestive/alimentary MP:0005381 9.88 PTEN KIT SMARCA4 MAP2K1 NRAS HRAS
3 integument MP:0010771 9.87 PTEN KIT SMARCA4 MAP2K1 MLANA NRAS
4 endocrine/exocrine gland MP:0005379 9.85 PTEN KIT SMARCA4 MAP2K1 NRAS HRAS
5 craniofacial MP:0005382 9.83 KIT SMARCA4 MAP2K1 NRAS HRAS
6 neoplasm MP:0002006 9.73 SMARCA4 MAP2K1 NRAS HRAS PTEN KIT
7 normal MP:0002873 9.7 PTEN KIT SMARCA4 MAP2K1 CALB2 NRAS
8 pigmentation MP:0001186 9.26 PTEN KIT MLANA NRAS
9 skeleton MP:0005390 9.1 PTEN KIT SMARCA4 MAP2K1 NRAS HRAS

Drugs & Therapeutics for Ovarian Melanoma

Search Clinical Trials , NIH Clinical Center for Ovarian Melanoma

Genetic Tests for Ovarian Melanoma

Anatomical Context for Ovarian Melanoma

Publications for Ovarian Melanoma

Articles related to Ovarian Melanoma:

# Title Authors Year
1
Title ultrasound features of ovarian melanoma metastases: The &amp;quot;Golf ball&amp;quot; aspect. ( 29198556 )
2018
2
Ovarian melanoma complicating pregnancy achieved by in-vitro fertilisation. ( 23259897 )
2013
3
Metastatic malignant ovarian melanoma--a case report. ( 23607194 )
2013
4
Malignant ovarian melanoma with extensive pelvic and peritoneal metastasis: a case report and literature review. ( 20346227 )
2010
5
Primary ovarian melanoma arising in a dermoid stage IIIc: long-term disease-free survival with aggressive surgery and platinum therapy. ( 8462906 )
1993
6
Ovarian melanoma. An interesting case. ( 6144596 )
1984
7
Malignant metastatic ovarian melanoma: a case report. ( 7347681 )
1981

Variations for Ovarian Melanoma

Expression for Ovarian Melanoma

Search GEO for disease gene expression data for Ovarian Melanoma.

Pathways for Ovarian Melanoma

Pathways related to Ovarian Melanoma according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CALD1 HRAS MAP2K1 NRAS PTEN
2
Show member pathways
13.25 HRAS KIT MAP2K1 NRAS SMARCA4
3
Show member pathways
13.22 HRAS KIT MAP2K1 NRAS PTEN
4
Show member pathways
12.95 HRAS KIT MAP2K1 NRAS
5
Show member pathways
12.93 HRAS KIT MAP2K1 NRAS PTEN
6
Show member pathways
12.92 HRAS KIT MAP2K1 NRAS
7
Show member pathways
12.84 HRAS MAP2K1 NRAS PTEN
8
Show member pathways
12.84 HRAS KIT MAP2K1 NRAS PTEN
9
Show member pathways
12.82 HRAS MAP2K1 NRAS PTEN
10
Show member pathways
12.81 HRAS MAP2K1 NRAS PTEN
11
Show member pathways
12.8 CALD1 HRAS KIT MAP2K1 NRAS
12
Show member pathways
12.78 HRAS MAP2K1 NRAS PTEN
13
Show member pathways
12.72 HRAS KIT MAP2K1 NRAS PTEN
14
Show member pathways
12.71 HRAS MAP2K1 NRAS PTEN
15
Show member pathways
12.7 HRAS MAP2K1 NRAS PTEN
16
Show member pathways
12.69 HRAS MAP2K1 NRAS PTEN
17 12.68 HRAS KIT MAP2K1 NRAS
18 12.68 HRAS KIT MAP2K1 NRAS PTEN
19
Show member pathways
12.65 HRAS KIT MAP2K1 NRAS
20
Show member pathways
12.64 HRAS KIT NRAS PTEN
21
Show member pathways
12.64 CALD1 HRAS MAP2K1 NRAS
22
Show member pathways
12.62 HRAS MAP2K1 NRAS PTEN
23
Show member pathways
12.57 HRAS MAP2K1 NRAS PTEN
24
Show member pathways
12.49 HRAS MAP2K1 NRAS PTEN
25
Show member pathways
12.47 HRAS MAP2K1 NRAS PTEN
26 12.41 HRAS MAP2K1 NRAS PTEN
27
Show member pathways
12.4 HRAS MAP2K1 NRAS PTEN
28
Show member pathways
12.39 HRAS MAP2K1 NRAS
29
Show member pathways
12.38 HRAS MAP2K1 NRAS PTEN
30
Show member pathways
12.36 HRAS MAP2K1 NRAS
31
Show member pathways
12.36 HRAS MAP2K1 NRAS
32
Show member pathways
12.35 HRAS MAP2K1 NRAS
33
Show member pathways
12.34 HRAS MAP2K1 NRAS
34
Show member pathways
12.29 HRAS KIT MAP2K1 NRAS
35
Show member pathways
12.27 HRAS MAP2K1 NRAS PTEN
36
Show member pathways
12.23 HRAS MAP2K1 NRAS
37 12.23 HRAS MAP2K1 NRAS
38
Show member pathways
12.22 HRAS MAP2K1 NRAS PTEN
39
Show member pathways
12.15 HRAS MAP2K1 NRAS
40
Show member pathways
12.15 HRAS MAP2K1 NRAS
41
Show member pathways
12.13 HRAS MAP2K1 NRAS
42 12.12 HRAS MAP2K1 PTEN
43
Show member pathways
12.11 HRAS MAP2K1 NRAS
44
Show member pathways
12.1 HRAS KIT MAP2K1 NRAS PTEN SMARCA4
45 12.09 HRAS NRAS PTEN
46
Show member pathways
12.09 HRAS MAP2K1 NRAS PTEN
47
Show member pathways
12.08 HRAS MAP2K1 NRAS
48
Show member pathways
12.06 HRAS MAP2K1 PTEN
49 12.03 HRAS MAP2K1 NRAS
50
Show member pathways
12.03 HRAS KIT MAP2K1 PTEN

GO Terms for Ovarian Melanoma

Biological processes related to Ovarian Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 HRAS KIT MAP2K1 PTEN
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.5 KIT PTEN SMARCA4
3 ERBB2 signaling pathway GO:0038128 9.4 HRAS NRAS
4 cellular senescence GO:0090398 9.37 HRAS MAP2K1
5 MAPK cascade GO:0000165 9.26 HRAS KIT MAP2K1 NRAS
6 regulation of axon regeneration GO:0048679 9.16 MAP2K1 PTEN
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 8.92 HRAS KIT MAP2K1 PTEN

Molecular functions related to Ovarian Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.02 HRAS KIT MAP2K1 NRAS SMARCA4

Sources for Ovarian Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....