MCID: OVR104
MIFTS: 22

Ovarian Melanoma

Categories: Cancer diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Ovarian Melanoma

MalaCards integrated aliases for Ovarian Melanoma:

Name: Ovarian Melanoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050928

Summaries for Ovarian Melanoma

Disease Ontology : 12 An ovarian cancer that has material basis in melanoctyes.

MalaCards based summary : Ovarian Melanoma is related to melanoma, cutaneous malignant 10 and melanoma. An important gene associated with Ovarian Melanoma is MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1). The drugs Antibodies and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and colon, and related phenotypes are Increased viability and Increased viability

Related Diseases for Ovarian Melanoma

Diseases related to Ovarian Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 melanoma, cutaneous malignant 10 10.1
2 melanoma 10.1
3 adult type testicular granulosa cell tumor 10.1 MLANA CALB2
4 angiosarcoma 10.1 MLANA CALB2
5 lentigines 10.0 MLANA MAP2K1
6 thymus clear cell carcinoma 10.0 MLANA CALB2
7 ovarian sex-cord stromal tumor 10.0 MLANA CALB2
8 mucinous stomach adenocarcinoma 10.0 MLANA CALB2
9 perivascular epithelioid cell tumor 10.0 MLANA CALD1
10 vascular cancer 10.0 MLANA CALD1
11 glomangiosarcoma 10.0 MLANA CALD1
12 benign perivascular tumor 10.0 MLANA CALD1
13 sarcomatoid squamous cell skin carcinoma 10.0 MLANA CALD1
14 small intestine leiomyoma 10.0 MLANA CALD1
15 intravascular fasciitis 10.0 MLANA CALD1
16 angiolipoma 9.9 MLANA CALD1
17 retroperitoneal sarcoma 9.9 MLANA CALD1
18 lung leiomyosarcoma 9.9 CALD1 CALB2
19 peritoneal benign neoplasm 9.9 CALD1 CALB2
20 sex cord-gonadal stromal tumor 9.9 MLANA CALB2
21 glomangiomatosis 9.9 MLANA CALD1
22 vaginal endometrial stromal sarcoma 9.9 MLANA CALD1
23 granular cell tumor 9.9 MLANA CALB2
24 infiltrating angiolipoma 9.9 MLANA CALD1
25 testicular fibroma 9.9 CALD1 CALB2
26 uterus leiomyosarcoma 9.9 MLANA CALD1
27 ovarian endometrioid stromal sarcoma 9.9 CALD1 CALB2
28 vagina sarcoma 9.9 MLANA CALD1
29 retroperitoneum carcinoma 9.9 MLANA CALD1
30 urethral benign neoplasm 9.9 CALD1 CALB2
31 benign peritoneal mesothelioma 9.8 CALD1 CALB2
32 adrenal cortical carcinoma 9.8 MLANA CALB2
33 glomus tumor 9.8 CALD1 CALB2
34 hemangiopericytoma, malignant 9.8 MLANA CALD1
35 mesenchymal cell neoplasm 9.8 MLANA CALD1
36 mixed cell type cancer 9.8 CALD1 CALB2
37 pleurisy 9.7
38 cystic teratoma 9.7
39 teratoma 9.7
40 malignant choroid melanoma 9.7
41 skin melanoma 9.7
42 neurilemmoma 9.7 MLANA CALB2
43 reproductive organ benign neoplasm 9.7 CALD1 CALB2
44 lipomatosis, multiple 9.7 MLANA CALD1
45 cervical polyp 9.7 MAPK8IP1 CALD1
46 vaginal cancer 9.6 MAPK8IP1 CALD1
47 uterus perivascular epithelioid cell tumor 9.6 MLANA CALD1 CALB2
48 cardiovascular cancer 9.6 MLANA CALD1 CALB2
49 connective tissue benign neoplasm 9.6 MLANA CALD1 CALB2
50 muscle cancer 9.6 MLANA CALD1

Graphical network of the top 20 diseases related to Ovarian Melanoma:



Diseases related to Ovarian Melanoma

Symptoms & Phenotypes for Ovarian Melanoma

GenomeRNAi Phenotypes related to Ovarian Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability GR00342-S-1 8.8 MAP2K1
2 Increased viability GR00342-S-2 8.8 MAP2K1
3 Increased viability GR00342-S-3 8.8 MAP2K1

Drugs & Therapeutics for Ovarian Melanoma

Drugs for Ovarian Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1
2 Antibodies, Monoclonal Phase 1
3 Immunoglobulins Phase 1
4 Immunologic Factors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of the Safety, Tolerability, and Pharmacokinetics of MORAb-004, a Humanized Monoclonal Antibody, in Subjects With Solid Tumors Completed NCT00847054 Phase 1 MORAb-004 (monoclonal antibody to TEM1)

Search NIH Clinical Center for Ovarian Melanoma

Genetic Tests for Ovarian Melanoma

Anatomical Context for Ovarian Melanoma

MalaCards organs/tissues related to Ovarian Melanoma:

40
Ovary, Breast, Colon, Prostate, Testes, T Cells

Publications for Ovarian Melanoma

Articles related to Ovarian Melanoma:

(show all 49)
# Title Authors PMID Year
1
A Report of a Rare Case of an Advanced Adult Granulosa Cell Tumor Initially Diagnosed as Primary Ovarian Melanoma. 61
32499969 2020
2
Targeting cancer stem cells by melatonin: Effective therapy for cancer treatment. 61
32171553 2020
3
SEOM clinical guideline for secondary prevention (2019). 61
32006339 2020
4
Organ Biodistribution of Radiolabelled γδ T Cells Following Liposomal Alendronate Administration in Different Mouse Tumour Models. 61
32190534 2020
5
Preclinical testing of 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide: a potent protein kinase C-ι inhibitor as a potential prostate carcinoma therapeutic. 61
30204596 2019
6
Overexpression of TBX3 transcription factor as a potential diagnostic marker for breast cancer. 61
30655984 2019
7
A rare melanoma feature with primary ovarian origin: a case report and the literature review. 61
29564322 2018
8
Title ultrasound features of ovarian melanoma metastases: The "Golf ball" aspect. 61
29198556 2018
9
In Defense of Progesterone: A Review of the Literature. 61
29055286 2017
10
Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type. 61
26645725 2016
11
Synthesis, biological evaluation, drug-likeness, and in silico screening of novel benzylidene-hydrazone analogues as small molecule anticancer agents. 61
26694484 2016
12
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. 61
25945974 2015
13
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine. 61
25968887 2015
14
Malignant melanoma arising in an ovarian mature cystic teratoma - a rare entity. 61
26023561 2015
15
Primary gynecologic melanoma: A report of two unusual cases. 61
26076092 2015
16
Expression of breast cancer metastasis suppressor-1, BRMS-1, in human breast cancer and the biological impact of BRMS-1 on the migration of breast cancer cells. 61
24596389 2014
17
Metastatic malignant ovarian melanoma--a case report. 61
23607194 2013
18
Ovarian melanoma complicating pregnancy achieved by in-vitro fertilisation. 61
23259897 2013
19
Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice. 61
23302993 2012
20
Effects of individual-level socioeconomic factors on racial disparities in cancer treatment and survival: findings from the National Longitudinal Mortality Study, 1979-2003. 61
21264829 2011
21
Metastatic ovarian malignant melanoma with no obvious primary. 61
24591988 2011
22
Ovarian malignant melanoma: a clinicopathologic study of 5 cases. 61
18794169 2010
23
Malignant ovarian melanoma with extensive pelvic and peritoneal metastasis: a case report and literature review. 61
20346227 2010
24
Mutations of the KIT gene and loss of heterozygosity of the PTEN region in a primary malignant melanoma arising from a mature cystic teratoma of the ovary. 61
19264228 2009
25
Identification of human pancreatic cancer stem cells. 61
19582426 2009
26
GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors. 61
16391803 2006
27
Malignant melanoma and fibrothecoma--an ovarian mixed tumor. 61
16033067 2005
28
Ovarian cystic teratoma with primary epithelial cell melanoma. 61
15755005 2005
29
Carbonic anhydrase inhibitors: sulfonamides as antitumor agents? 61
11310605 2001
30
Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin? 61
11496835 2001
31
4-toluenesulfonylureido derivatives of amines, amino acids and dipeptides: a novel class of potential antitumor agents. 61
11033076 2000
32
Carbonic anhydrase inhibitors--Part 94. 1,3,4-thiadiazole-2-sulfonamidederivatives as antitumor agents? 61
11203012 2000
33
Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents. 61
10969992 2000
34
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV. 61
10843231 2000
35
Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors. 61
11140614 2000
36
Malignant melanoma metastatic to the ovary: presentation and radiological characteristics. 61
9600825 1998
37
Malignant melanoma arising in mature ovarian cystic teratoma (dermoid cyst). Report of two cases and literature analysis. 61
8886884 1996
38
Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer. 61
7718330 1995
39
Malignant melanoma of the female genital system. 61
8181579 1994
40
[Metastatic ovarian melanoma in a 26-year-old patient]. 61
7941811 1994
41
Primary ovarian melanoma arising in a dermoid stage IIIc: long-term disease-free survival with aggressive surgery and platinum therapy. 61
8462906 1993
42
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. 61
1350507 1992
43
Malignant melanoma arising in ovarian cystic teratoma. 61
1959792 1991
44
Malignant melanoma presenting as a unilateral ovarian neoplasm. 61
2424811 1986
45
Comparative studies of ampligen (mismatched double-stranded RNA) and interferons. 61
2418160 1985
46
Ovarian melanoma. An interesting case. 61
6144596 1984
47
Malignant metastatic ovarian melanoma: a case report. 61
7347681 1981
48
Selection of malignant melanoma variant cell lines for ovary colonization. 61
544929 1979
49
A compound nevus in a benign cystic teratoma of the ovary. 61
937274 1976

Variations for Ovarian Melanoma

Expression for Ovarian Melanoma

Search GEO for disease gene expression data for Ovarian Melanoma.

Pathways for Ovarian Melanoma

GO Terms for Ovarian Melanoma

Molecular functions related to Ovarian Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP1 MAP2K1

Sources for Ovarian Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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