MCID: OVR104
MIFTS: 31

Ovarian Melanoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Ovarian Melanoma

MalaCards integrated aliases for Ovarian Melanoma:

Name: Ovarian Melanoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050928

Summaries for Ovarian Melanoma

Disease Ontology : 12 An ovarian cancer that has material basis in melanoctyes.

MalaCards based summary : Ovarian Melanoma is related to melanoma and senile angioma. An important gene associated with Ovarian Melanoma is MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1), and among its related pathways/superpathways are Integrin Pathway and Cytokine Signaling in Immune system. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Melanoma

Diseases related to Ovarian Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 melanoma 29.8 MAP2K1 MLANA NRAS PTEN
2 senile angioma 10.3 KIT MAP2K1
3 malignant spindle cell melanoma 10.2 KIT NRAS
4 acral lentiginous melanoma 10.2 KIT NRAS
5 giant congenital nevus 10.2 HRAS NRAS
6 mixed type thymoma 10.2 KIT PTEN
7 benign struma ovarii 10.2 HRAS NRAS
8 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
9 malignant conjunctival melanoma 10.2 HRAS NRAS
10 melanomatosis 10.2 HRAS NRAS
11 congenital mesoblastic nephroma 10.2 KIT NRAS
12 marcus gunn phenomenon 10.2 HRAS NRAS
13 ovarian fibrothecoma 10.2 CALB2 KIT
14 prostate small cell carcinoma 10.2 KIT PTEN
15 thymoma, familial 10.2 HRAS KIT
16 mucosal melanoma 10.2 KIT NRAS
17 malignant struma ovarii 10.2 HRAS NRAS
18 nodular malignant melanoma 10.2 HRAS NRAS
19 aggressive digital papillary adenocarcinoma 10.2 HRAS KIT
20 malignant leydig cell tumor 10.2 CALB2 KIT
21 fetal adenoma 10.2 HRAS NRAS
22 lung adenoid cystic carcinoma 10.2 HRAS KIT
23 myelodysplastic myeloproliferative cancer 10.2 HRAS NRAS
24 meningeal melanomatosis 10.1 HRAS NRAS
25 rete testis adenocarcinoma 10.1 CALB2 KIT
26 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS
27 mixed germ cell-sex cord neoplasm 10.1 CALB2 KIT
28 neurogenic bowel 10.1 CALB2 KIT
29 malignant anus melanoma 10.1 KIT MLANA
30 rete testis neoplasm 10.1 CALB2 KIT
31 functional colonic disease 10.1 CALB2 KIT
32 breast angiosarcoma 10.1 KIT MLANA
33 costello syndrome 10.1 HRAS MAP2K1
34 liver angiosarcoma 10.1 HRAS NRAS
35 mixed cell type cancer 10.1 HRAS KIT
36 undifferentiated pleomorphic sarcoma 10.0 KIT MLANA
37 colonic pseudo-obstruction 10.0 CALB2 KIT
38 meningeal melanocytoma 10.0 MLANA NRAS
39 acneiform dermatitis 10.0 HRAS MAP2K1 NRAS
40 small cell carcinoma 10.0 KIT PTEN SMARCA4
41 deep leiomyoma 10.0 CALD1 KIT
42 pancreatic mucinous cystadenoma 10.0 CALB2 HRAS
43 dysgerminoma of ovary 10.0 CALB2 KIT
44 core binding factor acute myeloid leukemia 10.0 HRAS KIT NRAS
45 myeloid leukemia 10.0 HRAS KIT NRAS
46 angiomyoma 10.0 CALD1 KIT
47 pulmonic stenosis 10.0 HRAS MAP2K1
48 ovarian brenner tumor 9.9 CALB2 KIT
49 mesenchymal cell neoplasm 9.9 CALD1 KIT
50 thyroid cancer, nonmedullary, 2 9.9 HRAS NRAS PTEN

Graphical network of the top 20 diseases related to Ovarian Melanoma:



Diseases related to Ovarian Melanoma

Symptoms & Phenotypes for Ovarian Melanoma

GenomeRNAi Phenotypes related to Ovarian Melanoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.28 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.28 NRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.28 HRAS NRAS SMARCA4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.28 HRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.28 NRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.28 HRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.28 HRAS

MGI Mouse Phenotypes related to Ovarian Melanoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 HRAS KIT MAP2K1 NRAS PTEN SMARCA4
2 digestive/alimentary MP:0005381 9.88 HRAS KIT MAP2K1 NRAS PTEN SMARCA4
3 integument MP:0010771 9.87 HRAS KIT MAP2K1 MLANA NRAS PTEN
4 endocrine/exocrine gland MP:0005379 9.85 HRAS KIT MAP2K1 NRAS PTEN SMARCA4
5 craniofacial MP:0005382 9.83 HRAS KIT MAP2K1 NRAS SMARCA4
6 neoplasm MP:0002006 9.73 HRAS KIT MAP2K1 NRAS PTEN SMARCA4
7 normal MP:0002873 9.7 CALB2 HRAS KIT MAP2K1 NRAS PTEN
8 pigmentation MP:0001186 9.26 KIT MLANA NRAS PTEN
9 skeleton MP:0005390 9.1 HRAS KIT MAP2K1 NRAS PTEN SMARCA4

Drugs & Therapeutics for Ovarian Melanoma

Search Clinical Trials , NIH Clinical Center for Ovarian Melanoma

Genetic Tests for Ovarian Melanoma

Anatomical Context for Ovarian Melanoma

Publications for Ovarian Melanoma

Articles related to Ovarian Melanoma:

# Title Authors Year
1
Title ultrasound features of ovarian melanoma metastases: The &amp;quot;Golf ball&amp;quot; aspect. ( 29198556 )
2018
2
Ovarian melanoma complicating pregnancy achieved by in-vitro fertilisation. ( 23259897 )
2013
3
Metastatic malignant ovarian melanoma--a case report. ( 23607194 )
2013
4
Malignant ovarian melanoma with extensive pelvic and peritoneal metastasis: a case report and literature review. ( 20346227 )
2010
5
Primary ovarian melanoma arising in a dermoid stage IIIc: long-term disease-free survival with aggressive surgery and platinum therapy. ( 8462906 )
1993
6
Ovarian melanoma. An interesting case. ( 6144596 )
1984
7
Malignant metastatic ovarian melanoma: a case report. ( 7347681 )
1981

Variations for Ovarian Melanoma

Expression for Ovarian Melanoma

Search GEO for disease gene expression data for Ovarian Melanoma.

Pathways for Ovarian Melanoma

Pathways related to Ovarian Melanoma according to GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CALD1 HRAS MAP2K1 NRAS PTEN
2
Show member pathways
13.25 HRAS KIT MAP2K1 NRAS SMARCA4
3
Show member pathways
13.21 HRAS KIT MAP2K1 NRAS PTEN
4
Show member pathways
12.95 HRAS KIT MAP2K1 NRAS
5
Show member pathways
12.94 HRAS KIT MAP2K1 NRAS PTEN
6
Show member pathways
12.86 HRAS MAP2K1 NRAS PTEN
7
Show member pathways
12.86 HRAS KIT MAP2K1 NRAS PTEN
8
Show member pathways
12.85 HRAS MAP2K1 NRAS PTEN
9
Show member pathways
12.83 HRAS MAP2K1 NRAS PTEN
10
Show member pathways
12.82 HRAS MAP2K1 NRAS PTEN
11
Show member pathways
12.81 HRAS MAP2K1 NRAS PTEN
12
Show member pathways
12.8 CALD1 HRAS KIT MAP2K1 NRAS
13
Show member pathways
12.78 HRAS MAP2K1 NRAS PTEN
14
Show member pathways
12.73 HRAS KIT MAP2K1 NRAS PTEN
15 12.68 HRAS KIT MAP2K1 NRAS PTEN
16 12.67 HRAS KIT MAP2K1 NRAS
17
Show member pathways
12.65 CALD1 HRAS MAP2K1 NRAS
18
Show member pathways
12.64 HRAS KIT MAP2K1 NRAS
19
Show member pathways
12.64 HRAS KIT NRAS PTEN
20
Show member pathways
12.61 HRAS MAP2K1 NRAS PTEN
21
Show member pathways
12.6 HRAS MAP2K1 NRAS PTEN
22
Show member pathways
12.57 HRAS MAP2K1 NRAS PTEN
23
Show member pathways
12.5 HRAS MAP2K1 NRAS
24
Show member pathways
12.49 HRAS MAP2K1 NRAS PTEN
25 12.42 HRAS MAP2K1 NRAS PTEN
26
Show member pathways
12.4 HRAS MAP2K1 NRAS PTEN
27
Show member pathways
12.38 HRAS MAP2K1 NRAS PTEN
28
Show member pathways
12.36 HRAS MAP2K1 NRAS
29
Show member pathways
12.36 HRAS MAP2K1 NRAS
30
Show member pathways
12.35 HRAS MAP2K1 NRAS
31
Show member pathways
12.34 HRAS MAP2K1 NRAS
32
Show member pathways
12.32 HRAS MAP2K1 PTEN
33
Show member pathways
12.31 HRAS KIT MAP2K1 NRAS
34
Show member pathways
12.29 HRAS KIT MAP2K1 NRAS
35
Show member pathways
12.27 HRAS MAP2K1 NRAS
36
Show member pathways
12.27 HRAS MAP2K1 NRAS PTEN
37 12.23 HRAS MAP2K1 NRAS
38
Show member pathways
12.2 HRAS MAP2K1 NRAS PTEN
39
Show member pathways
12.19 HRAS MAP2K1 NRAS
40
Show member pathways
12.14 CALD1 HRAS MAP2K1 NRAS
41
Show member pathways
12.14 HRAS MAP2K1 NRAS
42
Show member pathways
12.13 HRAS MAP2K1 NRAS
43
Show member pathways
12.12 HRAS MAP2K1 NRAS
44 12.11 HRAS MAP2K1 PTEN
45
Show member pathways
12.1 HRAS MAP2K1 NRAS
46
Show member pathways
12.1 HRAS MAP2K1 NRAS PTEN
47
Show member pathways
12.1 HRAS KIT MAP2K1 NRAS PTEN SMARCA4
48
Show member pathways
12.09 HRAS MAP2K1 NRAS PTEN
49
Show member pathways
12.08 HRAS MAP2K1 NRAS
50 12.07 HRAS NRAS PTEN

GO Terms for Ovarian Melanoma

Biological processes related to Ovarian Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.62 HRAS KIT MAP2K1 PTEN
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.43 KIT PTEN SMARCA4
3 cellular senescence GO:0090398 9.4 HRAS MAP2K1
4 positive regulation of phospholipase C activity GO:0010863 9.37 HRAS KIT
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.26 HRAS KIT MAP2K1 PTEN
6 regulation of axon regeneration GO:0048679 9.16 MAP2K1 PTEN
7 MAPK cascade GO:0000165 8.92 HRAS KIT MAP2K1 NRAS

Molecular functions related to Ovarian Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.02 HRAS KIT MAP2K1 NRAS SMARCA4

Sources for Ovarian Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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