MCID: OVR104
MIFTS: 23

Ovarian Melanoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Ovarian Melanoma

MalaCards integrated aliases for Ovarian Melanoma:

Name: Ovarian Melanoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050928

Summaries for Ovarian Melanoma

Disease Ontology : 12 An ovarian cancer that has material basis in melanoctyes.

MalaCards based summary : Ovarian Melanoma is related to skin melanoma and melanoma. An important gene associated with Ovarian Melanoma is MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Oxytocin signaling pathway. Affiliated tissues include breast, ovary and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Ovarian Melanoma

Diseases related to Ovarian Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 skin melanoma 29.6 NRAS MLANA MAP2K1
2 melanoma 10.2
3 acneiform dermatitis 10.1 NRAS MAP2K1
4 meningeal melanoma 10.1 NRAS MLANA
5 meningeal melanomatosis 10.1 NRAS MLANA
6 melanomatosis 10.1 NRAS MLANA
7 malignant leptomeningeal tumor 10.1 NRAS MLANA
8 malignant anus melanoma 10.1 NRAS MLANA
9 conjunctival nevus 10.1 NRAS MLANA
10 malignant dermis tumor 10.1 NRAS MLANA
11 central nervous system melanocytic neoplasm 10.1 NRAS MLANA
12 malignant skin fibrous histiocytoma 10.1 NRAS MLANA
13 sensory organ benign neoplasm 10.1 NRAS MLANA
14 vulvar melanoma 10.1 NRAS MLANA
15 perivascular epithelioid cell tumor 10.0 MLANA CALD1
16 malignant conjunctival melanoma 10.0 NRAS MLANA
17 glomangiosarcoma 10.0 MLANA CALD1
18 spitzoid melanoma 10.0 NRAS MLANA
19 conjunctival cancer 10.0 NRAS MLANA
20 orbit rhabdomyosarcoma 10.0 NRAS MLANA
21 benign perivascular tumor 10.0 MLANA CALD1
22 small intestine leiomyoma 10.0 MLANA CALD1
23 malignant spindle cell melanoma 10.0 NRAS MLANA
24 sarcomatoid squamous cell skin carcinoma 10.0 MLANA CALD1
25 skin sarcoma 10.0 MLANA CALD1
26 infiltrating angiolipoma 10.0 MLANA CALD1
27 angiolipoma 10.0 MLANA CALD1
28 intravascular fasciitis 10.0 MLANA CALD1
29 nodular malignant melanoma 10.0 NRAS MLANA
30 retroperitoneal sarcoma 10.0 MLANA CALD1
31 glomangiomatosis 10.0 MLANA CALD1
32 vagina sarcoma 10.0 MLANA CALD1
33 large congenital melanocytic nevus 10.0 NRAS MLANA
34 uterus leiomyosarcoma 10.0 MLANA CALD1
35 uterine corpus sarcoma 10.0 MLANA CALD1
36 retroperitoneum carcinoma 10.0 MLANA CALD1
37 bladder sarcoma 10.0 MLANA CALD1
38 melanoma in congenital melanocytic nevus 9.9 NRAS MLANA
39 adult type testicular granulosa cell tumor 9.9 MLANA CALB2
40 cystic teratoma 9.9
41 teratoma 9.9
42 angiosarcoma 9.9 MLANA CALB2
43 mesenchymal cell neoplasm 9.9 MLANA CALD1
44 langerhans cell histiocytosis 9.9 NRAS MAP2K1
45 mucinous stomach adenocarcinoma 9.9 MLANA CALB2
46 lipomatosis, multiple 9.9 MLANA CALD1
47 thymus clear cell carcinoma 9.9 MLANA CALB2
48 histiocytosis 9.9 NRAS MAP2K1
49 ovarian sex-cord stromal tumor 9.9 MLANA CALB2
50 well-differentiated liposarcoma 9.9 MLANA CALD1

Graphical network of the top 20 diseases related to Ovarian Melanoma:



Diseases related to Ovarian Melanoma

Symptoms & Phenotypes for Ovarian Melanoma

GenomeRNAi Phenotypes related to Ovarian Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.28 MAP2K1
2 Decreased viability GR00221-A-1 9.28 ADCK2 NRAS
3 Decreased viability GR00221-A-2 9.28 ADCK2
4 Decreased viability GR00221-A-3 9.28 ADCK2 MAP2K1 NRAS
5 Decreased viability GR00221-A-4 9.28 ADCK2
6 Decreased viability GR00342-S-3 9.28 ADCK2

Drugs & Therapeutics for Ovarian Melanoma

Search Clinical Trials , NIH Clinical Center for Ovarian Melanoma

Genetic Tests for Ovarian Melanoma

Anatomical Context for Ovarian Melanoma

MalaCards organs/tissues related to Ovarian Melanoma:

40
Breast, Ovary, Skin, Prostate, T Cells

Publications for Ovarian Melanoma

Articles related to Ovarian Melanoma:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Primary Ovarian Melanoma Arising From a Mature Teratoma With Melanoma In Situ Present in the Ciliated Columnar and Squamous Epithelium in a Patient With Synchronous Skin Basal Cell Carcinoma. 61
33560745 2021
2
Spontaneous subcapsular and perirenal haemorrhage with retroperitoneal haematoma in a patient with ovarian melanoma metastases. 61
33504529 2021
3
Targeting cancer stem cells by melatonin: Effective therapy for cancer treatment. 61
32171553 2020
4
A Report of a Rare Case of an Advanced Adult Granulosa Cell Tumor Initially Diagnosed as Primary Ovarian Melanoma. 61
32499969 2020
5
SEOM clinical guideline for secondary prevention (2019). 61
32006339 2020
6
Organ Biodistribution of Radiolabelled γδ T Cells Following Liposomal Alendronate Administration in Different Mouse Tumour Models. 61
32190534 2020
7
Overexpression of TBX3 transcription factor as a potential diagnostic marker for breast cancer. 61
30655984 2019
8
Preclinical testing of 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide: a potent protein kinase C-ι inhibitor as a potential prostate carcinoma therapeutic. 61
30204596 2019
9
A rare melanoma feature with primary ovarian origin: a case report and the literature review. 61
29564322 2018
10
Title ultrasound features of ovarian melanoma metastases: The "Golf ball" aspect. 61
29198556 2018
11
In Defense of Progesterone: A Review of the Literature. 61
29055286 2017
12
Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type. 61
26645725 2016
13
Synthesis, biological evaluation, drug-likeness, and in silico screening of novel benzylidene-hydrazone analogues as small molecule anticancer agents. 61
26694484 2016
14
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. 61
25945974 2015
15
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine. 61
25968887 2015
16
Malignant melanoma arising in an ovarian mature cystic teratoma - a rare entity. 61
26023561 2015
17
Primary gynecologic melanoma: A report of two unusual cases. 61
26076092 2015
18
Expression of breast cancer metastasis suppressor-1, BRMS-1, in human breast cancer and the biological impact of BRMS-1 on the migration of breast cancer cells. 61
24596389 2014
19
Metastatic malignant ovarian melanoma--a case report. 61
23607194 2013
20
Ovarian melanoma complicating pregnancy achieved by in-vitro fertilisation. 61
23259897 2013
21
Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice. 61
23302993 2012
22
Effects of individual-level socioeconomic factors on racial disparities in cancer treatment and survival: findings from the National Longitudinal Mortality Study, 1979-2003. 61
21264829 2011
23
Metastatic ovarian malignant melanoma with no obvious primary. 61
24591988 2011
24
Ovarian malignant melanoma: a clinicopathologic study of 5 cases. 61
18794169 2010
25
Malignant ovarian melanoma with extensive pelvic and peritoneal metastasis: a case report and literature review. 61
20346227 2010
26
Mutations of the KIT gene and loss of heterozygosity of the PTEN region in a primary malignant melanoma arising from a mature cystic teratoma of the ovary. 61
19264228 2009
27
Identification of human pancreatic cancer stem cells. 61
19582426 2009
28
GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors. 61
16391803 2006
29
Malignant melanoma and fibrothecoma--an ovarian mixed tumor. 61
16033067 2005
30
Ovarian cystic teratoma with primary epithelial cell melanoma. 61
15755005 2005
31
Carbonic anhydrase inhibitors: sulfonamides as antitumor agents? 61
11310605 2001
32
Arylsulfonyl-N,N-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting beta-tubulin? 61
11496835 2001
33
4-toluenesulfonylureido derivatives of amines, amino acids and dipeptides: a novel class of potential antitumor agents. 61
11033076 2000
34
Carbonic anhydrase inhibitors--Part 94. 1,3,4-thiadiazole-2-sulfonamidederivatives as antitumor agents? 61
11203012 2000
35
Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents. 61
10969992 2000
36
Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV. 61
10843231 2000
37
Carbonic anhydrase inhibitors: aromatic sulfonamides and disulfonamides act as efficient tumor growth inhibitors. 61
11140614 2000
38
Malignant melanoma metastatic to the ovary: presentation and radiological characteristics. 61
9600825 1998
39
Malignant melanoma arising in mature ovarian cystic teratoma (dermoid cyst). Report of two cases and literature analysis. 61
8886884 1996
40
Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer. 61
7718330 1995
41
Malignant melanoma of the female genital system. 61
8181579 1994
42
[Metastatic ovarian melanoma in a 26-year-old patient]. 61
7941811 1994
43
Primary ovarian melanoma arising in a dermoid stage IIIc: long-term disease-free survival with aggressive surgery and platinum therapy. 61
8462906 1993
44
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening. 61
1350507 1992
45
Malignant melanoma arising in ovarian cystic teratoma. 61
1959792 1991
46
Malignant melanoma presenting as a unilateral ovarian neoplasm. 61
2424811 1986
47
Comparative studies of ampligen (mismatched double-stranded RNA) and interferons. 61
2418160 1985
48
Ovarian melanoma. An interesting case. 61
6144596 1984
49
Malignant metastatic ovarian melanoma: a case report. 61
7347681 1981
50
Selection of malignant melanoma variant cell lines for ovary colonization. 61
544929 1979

Variations for Ovarian Melanoma

Expression for Ovarian Melanoma

Search GEO for disease gene expression data for Ovarian Melanoma.

Pathways for Ovarian Melanoma

Pathways related to Ovarian Melanoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 NRAS MAP2K1 CALD1
2
Show member pathways
11.79 NRAS MAP2K1 CALD1
3 11.49 NRAS MAP2K1
4
Show member pathways
11.46 NRAS MAP2K1
5 11.39 NRAS MAP2K1
6 11.37 NRAS MAP2K1
7 11.34 NRAS MAP2K1
8
Show member pathways
11.29 NRAS MAP2K1
9 11.26 NRAS MAP2K1
10 11.21 NRAS MAP2K1
11 11.05 NRAS MAP2K1
12 10.96 NRAS MAP2K1
13 10.84 NRAS MAP2K1
14 10.47 NRAS MAP2K1
15 9.92 NRAS MAP2K1

GO Terms for Ovarian Melanoma

Sources for Ovarian Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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