MCID: OVR015
MIFTS: 36

Ovarian Mixed Germ Cell Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mixed Germ Cell Neoplasm

MalaCards integrated aliases for Ovarian Mixed Germ Cell Neoplasm:

Name: Ovarian Mixed Germ Cell Neoplasm 12 15
Mixed Germ Cell Tumor of Ovary 12
Ovarian Mixed Germ Cell Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5936
NCIt 50 C8114
UMLS 70 C0280135

Summaries for Ovarian Mixed Germ Cell Neoplasm

Disease Ontology : 12 An ovarian primitive germ cell tumor that is characterized by the presence of two or more types of malignant, primitive, germ cell components.

MalaCards based summary : Ovarian Mixed Germ Cell Neoplasm, also known as mixed germ cell tumor of ovary, is related to mixed germ cell tumor and gonadoblastoma, and has symptoms including abdominal pain An important gene associated with Ovarian Mixed Germ Cell Neoplasm is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Pathways in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and thyroid, and related phenotypes are endocrine/exocrine gland and no phenotypic analysis

Related Diseases for Ovarian Mixed Germ Cell Neoplasm

Diseases related to Ovarian Mixed Germ Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.7 KIT CGA AFP
2 gonadoblastoma 30.6 WT1 KIT
3 sacrococcygeal teratoma 10.3 CGA AFP
4 triploidy 10.3 CGA AFP
5 germ cells tumors 10.3
6 rete testis neoplasm 10.3 PAX8 AFP
7 rete testis adenocarcinoma 10.3 PAX8 AFP
8 mediastinum seminoma 10.3 KIT AFP
9 cervical clear cell adenocarcinoma 10.3 PAX8 AFP
10 extragonadal seminoma 10.3 KIT AFP
11 pineal region teratoma 10.3 KIT AFP
12 gallbladder leiomyosarcoma 10.3 KIT AFP
13 intratubular embryonal carcinoma 10.3 KIT AFP
14 mixed germ cell cancer 10.3 KIT AFP
15 endometrial small cell carcinoma 10.3 KIT AFP
16 dysgerminoma of ovary 10.2 KIT AFP
17 brain germinoma 10.2 KIT AFP
18 testicular fibroma 10.2 WT1 AFP
19 thymus clear cell carcinoma 10.2 PAX8 KIT
20 ovarian seromucinous carcinoma 10.2 WT1 PAX8
21 juvenile type testicular granulosa cell tumor 10.2 WT1 AFP
22 testicular granulosa cell tumor 10.2 WT1 AFP
23 adenofibroma 10.2 PAX8 MME
24 ovarian large-cell neuroendocrine carcinoma 10.2 WT1 PAX8
25 liver lymphoma 10.2 MME AFP
26 middle ear carcinoma 10.2 WT1 AFP
27 small intestinal sarcoma 10.2 WT1 KIT
28 hepatic angiomyolipoma 10.2 MTOR AFP
29 nephrogenic adenoma of urinary bladder 10.2 PAX8 MME
30 sclerosing hepatic carcinoma 10.2 MME AFP
31 wolffian duct adenoma 10.2 PAX8 MME
32 adenosarcoma 10.2 MME KIT
33 hypereosinophilic syndrome, idiopathic 10.2 WT1 KIT
34 urethra leiomyoma 10.2 MME KIT
35 endosalpingiosis 10.2 WT1 PAX8
36 esophageal varix 10.2 SERPINA1 AFP
37 peritoneal serous adenocarcinoma 10.2 WT1 PAX8
38 hydrocele 10.2 CGA AFP
39 pancreatoblastoma 10.2 SERPINA1 AFP
40 uterus perivascular epithelioid cell tumor 10.2 PAX8 MME
41 46,xy sex reversal 1 10.2
42 amenorrhea 10.2
43 gonadal dysgenesis 10.2
44 46,xy sex reversal 10.2
45 adult cystic nephroma 10.2 MME KIT
46 nephrogenic adenoma of the urethra 10.2 PAX8 MME
47 adenomatoid tumor 10.1 WT1 AFP
48 sarcomatoid renal cell carcinoma 10.1 PAX8 KIT
49 orofaciodigital syndrome viii 10.1 CGA AFP
50 perivascular epithelioid cell tumor 10.1 MME KIT

Graphical network of the top 20 diseases related to Ovarian Mixed Germ Cell Neoplasm:



Diseases related to Ovarian Mixed Germ Cell Neoplasm

Symptoms & Phenotypes for Ovarian Mixed Germ Cell Neoplasm

UMLS symptoms related to Ovarian Mixed Germ Cell Neoplasm:


abdominal pain

MGI Mouse Phenotypes related to Ovarian Mixed Germ Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 AFP CGA KIT MTOR PAX8 PIK3CA
2 no phenotypic analysis MP:0003012 9.02 KIT MTOR PAX8 PIK3CA WT1

Drugs & Therapeutics for Ovarian Mixed Germ Cell Neoplasm

Drugs for Ovarian Mixed Germ Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
6
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
9
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11 Anti-Infective Agents Phase 3
12 Alkylating Agents Phase 3
13 Immunosuppressive Agents Phase 3
14 Antiviral Agents Phase 3
15 Antimetabolites Phase 3
16 Immunologic Factors Phase 3
17 Immunoglobulins Phase 3
18 Antibodies Phase 3
19 Antibodies, Monoclonal Phase 3
20 Antirheumatic Agents Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 3
22 Antihypertensive Agents Phase 3
23 HIV Protease Inhibitors Phase 3
24
protease inhibitors Phase 3
25 Hormones Phase 3
26 Hormone Antagonists Phase 3
27 Liposomal amphotericin B Phase 3
28 Anti-Bacterial Agents Phase 3
29 Antiparasitic Agents Phase 3
30 Antifungal Agents Phase 3
31 Antiprotozoal Agents Phase 3
32 Amebicides Phase 3
33 Cytochrome P-450 CYP3A Inhibitors Phase 3
34
Hydroxyitraconazole Phase 3 108222
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36
Ranitidine Approved, Withdrawn Phase 1, Phase 2 66357-59-3, 66357-35-5, 82530-72-1 3001055
37
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
38
Mesna Approved, Investigational Phase 1, Phase 2 3375-50-6 598
39
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
41
Chlorpheniramine Approved Phase 1, Phase 2 113-92-8, 132-22-9 2725
42
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
43
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
44
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
45
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
46
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
47
Lenograstim Approved, Investigational Phase 2 135968-09-1
48
Ifosfamide Approved Phase 2 3778-73-2 3690
49
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
50
Oprelvekin Approved, Investigational Phase 2 145941-26-0

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
2 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
3 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
4 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
7 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
8 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
9 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
10 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
11 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
12 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
13 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
14 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
15 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
16 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Ovarian Mixed Germ Cell Neoplasm

Genetic Tests for Ovarian Mixed Germ Cell Neoplasm

Anatomical Context for Ovarian Mixed Germ Cell Neoplasm

MalaCards organs/tissues related to Ovarian Mixed Germ Cell Neoplasm:

40
Ovary, Liver, Thyroid, Breast, Bone Marrow, Kidney, Bone

Publications for Ovarian Mixed Germ Cell Neoplasm

Articles related to Ovarian Mixed Germ Cell Neoplasm:

(show all 22)
# Title Authors PMID Year
1
Ovarian mixed germ cell tumor composed of polyembryoma and immature teratoma. 61 54
9648599 1998
2
Ovarian mixed germ-cell tumor comprising mature teratoma and embryonal carcinoma in a four-toed hedgehog (Atelerix albiventris). 61
33536394 2021
3
RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report. 61
32974172 2020
4
Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report. 61
30630520 2019
5
A variant c-KIT mutation, D816H, fundamental to the sequential development of an ovarian mixed germ cell tumor and systemic mastocytosis with chronic myelomonocytic leukemia. 61
27781377 2017
6
Extradural Spinal Metastasis in Ovarian Mixed Germ Cell Tumor. 61
28904580 2017
7
Ovarian Malignant Mixed Germ Cell Tumor: A Case of Unusual Presentation as Molar Pregnancy. 61
27141469 2016
8
A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors. 61
26548627 2016
9
Growing teratoma syndrome: first case report in a 4-year-old girl. 61
25256881 2015
10
Ovarian mixed germ cell tumor with yolk sac and teratomatous components in a dog. 61
23604259 2013
11
Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report. 61
22248255 2012
12
A transplant recipient with a mixed germ-cell ovarian tumor. 61
18974587 2008
13
Conservative management of ovarian mixed germ cell tumor associating polyembryoma and immature teratoma. 61
19437819 2008
14
Unusual location of ovarian mixed germ cell tumor. 61
16174255 2005
15
Ovarian mixed germ cell tumor with predominance of polyembryoma: a case report with literature review. 61
11781529 2002
16
Ovarian mixed germ cell tumor composed of endodermal sinus tumor and immature teratoma: case report. 61
10968342 2000
17
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review. 61
9702861 1998
18
Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma. 61
9605457 1998
19
[A case of ovarian mixed germ cell tumor consisting of four histological components]. 61
8393470 1993
20
Retroperitoneal giant tumor formed by migrating polyembryoma with numerous embryoid bodies from an ovarian mixed germ cell tumor. 61
1849112 1991
21
Mixed germ cell tumor of the ovary with pure choriocarcinoma metastasis. 61
3016631 1986
22
A rare malignant ovarian mixed germ cell tumor containing pancreatic tissue with islet cells. 61
6092290 1984

Variations for Ovarian Mixed Germ Cell Neoplasm

Expression for Ovarian Mixed Germ Cell Neoplasm

Search GEO for disease gene expression data for Ovarian Mixed Germ Cell Neoplasm.

Pathways for Ovarian Mixed Germ Cell Neoplasm

GO Terms for Ovarian Mixed Germ Cell Neoplasm

Biological processes related to Ovarian Mixed Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.61 PIK3CA MTOR KIT
2 kidney development GO:0001822 9.54 WT1 PAX8 MME
3 positive regulation of neurogenesis GO:0050769 9.48 MTOR MME
4 positive regulation of lamellipodium assembly GO:0010592 9.46 PIK3CA MTOR
5 negative regulation of anoikis GO:2000811 9.4 PIK3CA CEACAM5
6 negative regulation of macroautophagy GO:0016242 9.32 PIK3CA MTOR
7 anoikis GO:0043276 9.26 PIK3CA MTOR
8 cellular response to gonadotropin stimulus GO:0071371 9.16 WT1 PAX8
9 metanephric S-shaped body morphogenesis GO:0072284 8.96 WT1 PAX8
10 metanephric epithelium development GO:0072207 8.62 WT1 PAX8

Sources for Ovarian Mixed Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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