MCID: OVR015
MIFTS: 26

Ovarian Mixed Germ Cell Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mixed Germ Cell Neoplasm

MalaCards integrated aliases for Ovarian Mixed Germ Cell Neoplasm:

Name: Ovarian Mixed Germ Cell Neoplasm 12
Mixed Germ Cell Tumor of Ovary 12
Ovarian Mixed Germ Cell Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5936
NCIt 51 C8114
UMLS 74 C0280135

Summaries for Ovarian Mixed Germ Cell Neoplasm

Disease Ontology : 12 An ovarian primitive germ cell tumor that is characterized by the presence of two or more types of malignant, primitive, germ cell components.

MalaCards based summary : Ovarian Mixed Germ Cell Neoplasm, also known as mixed germ cell tumor of ovary, is related to mixed germ cell tumor and germ cells tumors, and has symptoms including abdominal pain An important gene associated with Ovarian Mixed Germ Cell Neoplasm is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. The drugs Captopril and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow.

Related Diseases for Ovarian Mixed Germ Cell Neoplasm

Diseases related to Ovarian Mixed Germ Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.0 AFP CGA
2 germ cells tumors 10.2
3 polyembryoma 9.8 AFP CGA
4 sacrococcygeal teratoma 9.8 AFP CGA
5 teratoma 9.8 AFP CGA
6 triploidy 9.8 AFP CGA
7 testicular seminoma 9.8 AFP CGA
8 seminoma 9.8 AFP CGA
9 chromosomal triplication 9.8 AFP CGA
10 orofaciodigital syndrome viii 9.8 AFP CGA
11 hydrocele 9.7 AFP CGA
12 placenta disease 9.7 AFP CGA
13 oligohydramnios 9.7 AFP CGA
14 germ cell cancer 9.6 AFP CGA
15 testicular cancer 9.5 AFP CGA

Graphical network of the top 20 diseases related to Ovarian Mixed Germ Cell Neoplasm:



Diseases related to Ovarian Mixed Germ Cell Neoplasm

Symptoms & Phenotypes for Ovarian Mixed Germ Cell Neoplasm

UMLS symptoms related to Ovarian Mixed Germ Cell Neoplasm:


abdominal pain

Drugs & Therapeutics for Ovarian Mixed Germ Cell Neoplasm

Drugs for Ovarian Mixed Germ Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Captopril Approved Phase 3 62571-86-2 44093
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Ribavirin Approved Phase 3 36791-04-5 37542
4
Palivizumab Approved, Investigational Phase 3 188039-54-5
5
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
10 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
11 Immunologic Factors Phase 3,Phase 1,Phase 2
12 Alkylating Agents Phase 3,Phase 1,Phase 2
13 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
14 Antiviral Agents Phase 3,Phase 1,Phase 2
15 Anti-Infective Agents Phase 3,Phase 1,Phase 2
16 Antimetabolites Phase 3,Phase 1,Phase 2
17 Antihypertensive Agents Phase 3
18 Angiotensin-Converting Enzyme Inhibitors Phase 3
19
protease inhibitors Phase 3
20 Antirheumatic Agents Phase 3
21 HIV Protease Inhibitors Phase 3
22 Antibodies, Monoclonal Phase 3,Phase 1
23 Antibodies Phase 3,Phase 1
24 Immunoglobulins Phase 3,Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
26 Hormone Antagonists Phase 3,Phase 1,Phase 2
27 Cytochrome P-450 CYP3A Inhibitors Phase 3
28 Cytochrome P-450 Enzyme Inhibitors Phase 3
29 Hormones Phase 3,Phase 1,Phase 2
30 Steroid Synthesis Inhibitors Phase 3
31 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
32
Hydroxyitraconazole Phase 3
33 Antifungal Agents Phase 3
34 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
35 Anti-Bacterial Agents Phase 3
36 Antiprotozoal Agents Phase 3
37 Antiparasitic Agents Phase 3
38 Liposomal amphotericin B Phase 3
39
Cisplatin Approved Phase 1, Phase 2,Phase 2 15663-27-1 2767 441203 84093
40
Ifosfamide Approved Phase 1, Phase 2,Phase 2 3778-73-2 3690
41
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
42
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 6251 453
43
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
44
Mechlorethamine Approved, Investigational Phase 1, Phase 2,Phase 2 51-75-2 4033
45
Ranitidine Approved Phase 1, Phase 2 66357-59-3, 66357-35-5 3001055
46
Paclitaxel Approved, Vet_approved Phase 1, Phase 2,Phase 2 33069-62-4 36314
47
Mesna Approved, Investigational Phase 1, Phase 2 3375-50-6 598
48
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
49
Lenograstim Approved, Investigational Phase 1, Phase 2,Phase 2 135968-09-1
50
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
7 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
10 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
11 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
12 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
13 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
14 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
15 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
16 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride
17 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
18 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
19 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
20 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Ovarian Mixed Germ Cell Neoplasm

Genetic Tests for Ovarian Mixed Germ Cell Neoplasm

Anatomical Context for Ovarian Mixed Germ Cell Neoplasm

MalaCards organs/tissues related to Ovarian Mixed Germ Cell Neoplasm:

42
Ovary, Bone, Bone Marrow, Brain, Colon, Small Intestine, Placenta

Publications for Ovarian Mixed Germ Cell Neoplasm

Articles related to Ovarian Mixed Germ Cell Neoplasm:

# Title Authors Year
1
Malignant mixed germ cell tumor of ovary presenting as advanced disease in an adolescent girl. ( 29787027 )
2016
2
Mixed germ cell tumor of ovary and clitoromegaly in Swyer's syndrome: a case report. ( 22773216 )
2012

Variations for Ovarian Mixed Germ Cell Neoplasm

Expression for Ovarian Mixed Germ Cell Neoplasm

Search GEO for disease gene expression data for Ovarian Mixed Germ Cell Neoplasm.

Pathways for Ovarian Mixed Germ Cell Neoplasm

Pathways related to Ovarian Mixed Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 AFP CGA

GO Terms for Ovarian Mixed Germ Cell Neoplasm

Sources for Ovarian Mixed Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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