MCID: OVR015
MIFTS: 25

Ovarian Mixed Germ Cell Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mixed Germ Cell Neoplasm

MalaCards integrated aliases for Ovarian Mixed Germ Cell Neoplasm:

Name: Ovarian Mixed Germ Cell Neoplasm 12
Mixed Germ Cell Tumor of Ovary 12
Ovarian Mixed Germ Cell Tumor 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5936
NCIt 50 C8114
UMLS 73 C0280135

Summaries for Ovarian Mixed Germ Cell Neoplasm

Disease Ontology : 12 An ovarian primitive germ cell tumor that is characterized by the presence of two or more types of malignant, primitive, germ cell components.

MalaCards based summary : Ovarian Mixed Germ Cell Neoplasm, also known as mixed germ cell tumor of ovary, is related to mixed germ cell tumor and germ cells tumors, and has symptoms including abdominal pain An important gene associated with Ovarian Mixed Germ Cell Neoplasm is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. The drugs Cyclophosphamide and Captopril have been mentioned in the context of this disorder. Affiliated tissues include ovary, bone and bone marrow.

Related Diseases for Ovarian Mixed Germ Cell Neoplasm

Diseases related to Ovarian Mixed Germ Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.1 AFP CGA
2 germ cells tumors 10.2
3 polyembryoma 9.9 AFP CGA
4 sacrococcygeal teratoma 9.9 AFP CGA
5 teratoma 9.9 AFP CGA
6 triploidy 9.9 AFP CGA
7 testicular seminoma 9.9 AFP CGA
8 seminoma 9.9 AFP CGA
9 chromosomal triplication 9.9 AFP CGA
10 orofaciodigital syndrome viii 9.8 AFP CGA
11 hydrocele 9.8 AFP CGA
12 placenta disease 9.8 AFP CGA
13 oligohydramnios 9.8 AFP CGA
14 germ cell cancer 9.8 AFP CGA
15 testicular cancer 9.7 AFP CGA

Graphical network of the top 20 diseases related to Ovarian Mixed Germ Cell Neoplasm:



Diseases related to Ovarian Mixed Germ Cell Neoplasm

Symptoms & Phenotypes for Ovarian Mixed Germ Cell Neoplasm

UMLS symptoms related to Ovarian Mixed Germ Cell Neoplasm:


abdominal pain

Drugs & Therapeutics for Ovarian Mixed Germ Cell Neoplasm

Drugs for Ovarian Mixed Germ Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
2
Captopril Approved Phase 3 62571-86-2 44093
3
Ribavirin Approved Phase 3 36791-04-5 37542
4
Palivizumab Approved, Investigational Phase 3 188039-54-5
5
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
6
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
7
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
8
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
9
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
10 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
11 Alkylating Agents Phase 3,Phase 1,Phase 2
12 Immunologic Factors Phase 3,Phase 1,Phase 2
13 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
14 Antimetabolites Phase 3,Phase 1,Phase 2
15 Anti-Infective Agents Phase 3,Phase 1,Phase 2
16 Antiviral Agents Phase 3,Phase 1,Phase 2
17 Antihypertensive Agents Phase 3
18
protease inhibitors Phase 3
19 Antirheumatic Agents Phase 3
20 HIV Protease Inhibitors Phase 3
21 Angiotensin-Converting Enzyme Inhibitors Phase 3
22 Immunoglobulins Phase 3,Phase 1
23 Antibodies Phase 3,Phase 1
24 Antibodies, Monoclonal Phase 3,Phase 1
25 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
26 Cytochrome P-450 CYP3A Inhibitors Phase 3
27 Steroid Synthesis Inhibitors Phase 3
28 Cytochrome P-450 Enzyme Inhibitors Phase 3
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
30
Hydroxyitraconazole Phase 3
31 Hormones Phase 3,Phase 1,Phase 2
32 Antifungal Agents Phase 3
33 Hormone Antagonists Phase 3,Phase 1,Phase 2
34 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
35 Liposomal amphotericin B Phase 3
36 Anti-Bacterial Agents Phase 3
37 Antiparasitic Agents Phase 3
38 Antiprotozoal Agents Phase 3
39 Echinocandins Phase 3
40
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
41
Mechlorethamine Approved, Investigational Phase 1, Phase 2,Phase 2 51-75-2 4033
42
Paclitaxel Approved, Vet_approved Phase 1, Phase 2,Phase 2 33069-62-4 36314
43
Lenograstim Approved, Investigational Phase 1, Phase 2,Phase 2 135968-09-1
44
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
45
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
46
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
47
Mesna Approved, Investigational Phase 1, Phase 2 3375-50-6 598
48
Ifosfamide Approved Phase 1, Phase 2,Phase 2 3778-73-2 3690
49
Cisplatin Approved Phase 1, Phase 2,Phase 2 15663-27-1 2767 441203 84093
50
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
3 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
4 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
5 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
6 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
7 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
8 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
9 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
10 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
11 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
12 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
13 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
14 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
15 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
16 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride
17 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
18 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
19 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
20 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable

Search NIH Clinical Center for Ovarian Mixed Germ Cell Neoplasm

Genetic Tests for Ovarian Mixed Germ Cell Neoplasm

Anatomical Context for Ovarian Mixed Germ Cell Neoplasm

MalaCards organs/tissues related to Ovarian Mixed Germ Cell Neoplasm:

41
Ovary, Bone, Bone Marrow, Placenta

Publications for Ovarian Mixed Germ Cell Neoplasm

Articles related to Ovarian Mixed Germ Cell Neoplasm:

# Title Authors Year
1
Malignant mixed germ cell tumor of ovary presenting as advanced disease in an adolescent girl. ( 29787027 )
2016
2
Mixed germ cell tumor of ovary and clitoromegaly in Swyer's syndrome: a case report. ( 22773216 )
2012

Variations for Ovarian Mixed Germ Cell Neoplasm

Expression for Ovarian Mixed Germ Cell Neoplasm

Search GEO for disease gene expression data for Ovarian Mixed Germ Cell Neoplasm.

Pathways for Ovarian Mixed Germ Cell Neoplasm

Pathways related to Ovarian Mixed Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 AFP CGA

GO Terms for Ovarian Mixed Germ Cell Neoplasm

Sources for Ovarian Mixed Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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