MCID: OVR011
MIFTS: 34

Ovarian Mucinous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mucinous Adenocarcinoma

MalaCards integrated aliases for Ovarian Mucinous Adenocarcinoma:

Name: Ovarian Mucinous Adenocarcinoma 12 15 17 72
Mucinous Carcinoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3606
NCIt 50 C5243
UMLS 72 C1335167

Summaries for Ovarian Mucinous Adenocarcinoma

Disease Ontology : 12 An ovary adenocarcinoma that is characterized by the presence of mucin.

MalaCards based summary : Ovarian Mucinous Adenocarcinoma, also known as mucinous carcinoma of ovary, is related to appendix adenocarcinoma and teratoma. An important gene associated with Ovarian Mucinous Adenocarcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Gastric cancer and Statin Pathway - Generalized, Pharmacokinetics. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include ovary, colon and lung.

Related Diseases for Ovarian Mucinous Adenocarcinoma

Diseases related to Ovarian Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.9 KRT7 KRT20 CDX2
2 teratoma 30.7 KRT7 CDX2
3 dermoid cyst 30.4 KRT7 KRT20
4 spindle cell carcinoma 30.1 KRT7 AMACR
5 mucinous adenocarcinoma 29.7 MUC2 KRT7 KRT20 CDX2
6 cystadenoma 29.4 MUC2 KRT7 KRT20
7 ovarian mucinous neoplasm 29.1 MUC2 KRT7 KRT20 CDX2
8 cystic teratoma 28.9 MUC2 KRT7 KRT20 CDX2
9 pseudomyxoma peritonei 28.9 MUC2 KRT7 KRT20 CDX2
10 colorectal adenocarcinoma 28.9 MUC2 KRT7 KRT20 CDX2
11 colorectal cancer 27.6 MUC2 KRT7 KRT20 CDX2 ABCB1
12 mucinous adenocarcinoma of ovary 11.9
13 ovary neuroendocrine neoplasm 10.5 KRT7 CDX2
14 anus adenocarcinoma 10.5 KRT7 CDX2
15 mucinous adenofibroma 10.5 KRT7 CDX2
16 adenocarcinoma 10.5
17 nasal cavity cancer 10.4 KRT7 CDX2
18 vaginal tubulovillous adenoma 10.4 KRT20 CDX2
19 nasal cavity adenocarcinoma 10.4 KRT7 CDX2
20 villous adenoma 10.4 KRT20 CDX2
21 vaginal adenoma 10.4 KRT20 CDX2
22 vaginal benign neoplasm 10.4 KRT20 CDX2
23 anal canal adenocarcinoma 10.4 KRT7 CDX2
24 mucinous ovarian cystadenoma 10.4 KRT7 CDX2
25 cystic basal cell carcinoma 10.4 KRT7 KRT20
26 malignant syringoma 10.4 KRT7 KRT20
27 transverse colon cancer 10.4 KRT7 KRT20
28 seminal vesicle adenocarcinoma 10.4 KRT7 KRT20
29 krukenberg carcinoma 10.4 KRT7 KRT20
30 papillary transitional carcinoma 10.4 KRT7 KRT20
31 small cell carcinoma 10.4 KRT7 KRT20
32 small cell carcinoma of the bladder 10.4 KRT7 KRT20
33 lung acinar adenocarcinoma 10.4 KRT7 KRT20
34 linitis plastica 10.4 KRT7 KRT20
35 large intestine adenocarcinoma 10.4 KRT7 KRT20
36 intratubular embryonal carcinoma 10.4 KRT7 KRT20
37 adenoid squamous cell carcinoma 10.4 KRT7 KRT20
38 bile duct adenoma 10.4 KRT7 KRT20
39 vulval paget's disease 10.4 KRT7 KRT20
40 meibomian cyst 10.4 KRT7 KRT20
41 papillary serous adenocarcinoma 10.3 KRT7 KRT20
42 bladder lymphoma 10.3 KRT7 KRT20
43 glycogen-rich clear cell breast carcinoma 10.3 KRT7 KRT20
44 anus cancer 10.3 KRT7 CDX2
45 medulloepithelioma 10.3 KRT7 KRT20
46 renal pelvis carcinoma 10.3 KRT7 KRT20
47 paget disease, extramammary 10.3 KRT7 KRT20
48 lymphoepithelioma-like carcinoma 10.3 KRT7 KRT20
49 renal adenoma 10.3 KRT7 AMACR
50 cystadenofibroma 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Ovarian Mucinous Adenocarcinoma:



Diseases related to Ovarian Mucinous Adenocarcinoma

Symptoms & Phenotypes for Ovarian Mucinous Adenocarcinoma

Drugs & Therapeutics for Ovarian Mucinous Adenocarcinoma

Drugs for Ovarian Mucinous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1
2 Immunoglobulins Phase 1
3 Antibodies, Monoclonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 With Expansion Cohorts in a Study of NEO-201 in Adults With Chemo-Resistant Solid Tumors Recruiting NCT03476681 Phase 1 NEO-201

Search NIH Clinical Center for Ovarian Mucinous Adenocarcinoma

Genetic Tests for Ovarian Mucinous Adenocarcinoma

Anatomical Context for Ovarian Mucinous Adenocarcinoma

MalaCards organs/tissues related to Ovarian Mucinous Adenocarcinoma:

41
Ovary, Colon, Lung, Appendix, Eye, Thyroid

Publications for Ovarian Mucinous Adenocarcinoma

Articles related to Ovarian Mucinous Adenocarcinoma:

(show all 40)
# Title Authors PMID Year
1
Significance of SATB2 expression in colon cancer and its differential diagnosis in digestive tract adenocarcinoma and ovarian primary and metastatic carcinoma. 38
31101576 2019
2
Response to "Novel" nomogram and algorithm do not aid in the distinction of primary vs. metastatic mucinous carcinoma of ovary: letter to the Editor. 38
31016434 2019
3
Anaplastic Carcinoma Arising From Ovarian Mucinous Adenocarcinoma With Massive Cardiopulmonary Metastasis: An Autopsy Case Report. 38
30393058 2019
4
Possible role of thymidine phosphorylase in gynecological tumors as an individualized treatment strategy. 38
27899985 2016
5
Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma. 38
27060927 2016
6
Ovarian mucinous adenocarcinoma with functioning stroma in postmenopausal women: aromatase and SF-1 expressions. 38
26576867 2015
7
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision? 38
25473748 2015
8
Primary ovarian mucinous adenocarcinoma of intestinal type: a clinicopathologic study of 46 cases. 38
24487473 2014
9
Dual inhibition of phosphatidylinositol 3'-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach for mucinous adenocarcinoma of the ovary. 38
24552895 2014
10
Association of pancreatic adenocarcinoma up-regulated factor expression in ovarian mucinous adenocarcinoma with poor prognosis. 38
25197383 2014
11
Slow progression of calcified cerebellar metastasis from ovarian cancer: a case report and review of the literature. 38
24077275 2013
12
Pre-invasive ovarian mucinous tumors are characterized by CDKN2A and RAS pathway aberrations. 38
22891197 2012
13
A case of ovarian mucinous adenocarcinoma in a premenarcheal girl. 38
22016113 2012
14
Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications. 38
22592533 2012
15
Differentiating rectal carcinoma by an immunohistological analysis of carcinomas of pelvic organs based on the NCBI Literature Survey and the Human Protein Atlas database. 38
22441574 2012
16
Prognostic significance of stromal microinvasion in the intestinal type of ovarian mucinous adenocarcinoma. 38
21556953 2011
17
Late presentation of a mucinous ovarian adenocarcinoma which was initially diagnosed as a primary pancreatic carcinoma: a case report and review of the literature. 38
20298585 2010
18
CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. 38
19926591 2010
19
High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary. 38
19787216 2009
20
Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: a potential treatment strategy. 38
19154404 2009
21
Gingival metastasis from ovarian mucinous cystadenocarcinoma as an initial manifestation (a rare case report). 38
19246966 2008
22
Ovarian mature teratomas with mucinous epithelial neoplasms: morphologic heterogeneity and association with pseudomyxoma peritonei. 38
18344868 2008
23
Advanced epithelial ovarian carcinoma during pregnancy. 38
17929120 2007
24
Mucinous carcinoma of thyroid gland. Report of a primary and a metastatic mucinous tumour from ovarian adenocarcinoma with immunohistochemical study and review of literature. 38
17704943 2007
25
Immunohistochemical expression of SMAD4, CK19, and CA19-9 in fine needle aspiration samples of pancreatic adenocarcinoma: Utility and potential role. 38
17587453 2007
26
Triple simultaneous primary gynecological malignancies in a 56-year-old patient. 38
17009998 2006
27
[Role of CDX2 immunostaining in diagnosis of gastrointestinal adenocarcinoma]. 38
16776981 2006
28
Combined positron emission tomography and computed tomography for the detection of recurrent ovarian mucinous adenocarcinoma. 38
15721446 2005
29
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. 38
15722802 2005
30
An ovarian mucinous adenocarcinoma arising from mature cystic teratoma associated with respiratory type tissue: a case report. 38
15656343 2004
31
Abdominal wall metastasis from ovarian cancer after laparotomy. A case report. 38
12556106 2002
32
Mucinous adenocarcinoma of the ovary metastatic to the eye: report of a case with diagnosis by fine needle aspiration biopsy. 38
11575663 2001
33
[Ovarian mucinous adenocarcinoma, mucocele of the appendix and pseudomyxoma peritonei: case report with immunohistochemical analysis]. 38
10756603 2000
34
Carcinoma of the ovary with primary presentation in the choroid. 38
10634571 1999
35
Identical, unique p53 mutations in a primary ovarian mucinous adenocarcinoma and a synchronous contralateral ovarian mucinous tumor of low malignant potential suggest a common clonal origin. 38
9158713 1997
36
Clinical evaluation of radioimmunoimaging with 131I-C0C183B2 monoclonal antibody against ovarian carcinoma by intraperitoneal injection. 38
1468700 1992
37
[In vitro studies on the expression of c-myc oncogene product in gynecological cultured cancer cells]. 38
1940543 1991
38
A preliminary study of radioimmunoimaging by 131I-COC183B2 monoclonal antibody in patients with epithelial ovarian cancer. 38
1874008 1991
39
[Characterization of immunoreactive hCG beta-subunit in cultured fluids of the cell lines derived from gynecologic malignant tumors]. 38
1703201 1990
40
[Reorganization of human ovarian adenocarcinoma cells and endometrial adenocarcinoma cells cultured in double-layered floating collagen gels]. 38
3027213 1986

Variations for Ovarian Mucinous Adenocarcinoma

Cosmic variations for Ovarian Mucinous Adenocarcinoma:

9 (show top 50) (show all 204)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM20640 WEE2 ovary,NS,carcinoma,mucinous carcinoma c.1193G>A p.R398H 7:141724247-141724247 6
2 COSM20669 ULK1 ovary,NS,carcinoma,mucinous carcinoma c.868G>A p.V290M 12:131910720-131910720 6
3 COSM6923559 TSC1 ovary,NS,carcinoma,mucinous carcinoma c.1997+1G>A p.? 9:132905580-132905580 6
4 COSM20712 TRRAP ovary,NS,carcinoma,mucinous carcinoma c.5786G>T p.R1929L 7:98955228-98955228 6
5 COSM10758 TP53 ovary,NS,carcinoma,mucinous carcinoma c.659A>G p.Y220C 17:7674872-7674872 6
6 COSM10662 TP53 ovary,NS,carcinoma,mucinous carcinoma c.743G>A p.R248Q 17:7674220-7674220 6
7 COSM10663 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 6
8 COSM11089 TP53 ovary,NS,carcinoma,mucinous carcinoma c.584T>C p.I195T 17:7674947-7674947 6
9 COSM10705 TP53 ovary,NS,carcinoma,mucinous carcinoma c.586C>T p.R196* 17:7674945-7674945 6
10 COSM10704 TP53 ovary,NS,carcinoma,mucinous carcinoma c.844C>T p.R282W 17:7673776-7673776 6
11 COSM10645 TP53 ovary,NS,carcinoma,mucinous carcinoma c.527G>T p.C176F 17:7675085-7675085 6
12 COSM44571 TP53 ovary,NS,carcinoma,mucinous carcinoma c.581T>G p.L194R 17:7674950-7674950 6
13 COSM10656 TP53 ovary,NS,carcinoma,mucinous carcinoma c.742C>T p.R248W 17:7674221-7674221 6
14 COSM10794 TP53 ovary,NS,carcinoma,mucinous carcinoma c.796G>A p.G266R 17:7673824-7673824 6
15 COSM6932 TP53 ovary,NS,carcinoma,mucinous carcinoma c.733G>A p.G245S 17:7674230-7674230 6
16 COSM46470 TP53 ovary,NS,carcinoma,mucinous carcinoma c.922C>G p.L308V 17:7673606-7673606 6
17 COSM10891 TP53 ovary,NS,carcinoma,mucinous carcinoma c.814G>A p.V272M 17:7673806-7673806 6
18 COSM43568 TP53 ovary,NS,carcinoma,mucinous carcinoma c.772G>T p.E258* 17:7674191-7674191 6
19 COSM10738 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 6
20 COSM10768 TP53 ovary,NS,carcinoma,mucinous carcinoma c.535C>T p.H179Y 17:7675077-7675077 6
21 COSM10893 TP53 ovary,NS,carcinoma,mucinous carcinoma c.824G>A p.C275Y 17:7673796-7673796 6
22 COSM11205 TP53 ovary,NS,carcinoma,mucinous carcinoma c.796G>C p.G266R 17:7673824-7673824 6
23 COSM44769 TP53 ovary,NS,carcinoma,mucinous carcinoma c.755T>C p.L252P 17:7674208-7674208 6
24 COSM11148 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 6
25 COSM10648 TP53 ovary,NS,carcinoma,mucinous carcinoma c.524G>A p.R175H 17:7675088-7675088 6
26 COSM44687 TP53 ovary,NS,carcinoma,mucinous carcinoma c.379T>C p.S127P 17:7675233-7675233 6
27 COSM46117 TP53 ovary,NS,carcinoma,mucinous carcinoma c.580C>G p.L194V 17:7674951-7674951 6
28 COSM44676 TP53 ovary,NS,carcinoma,mucinous carcinoma c.714T>G p.C238W 17:7674249-7674249 6
29 COSM44137 TP53 ovary,NS,carcinoma,mucinous carcinoma c.434T>A p.L145Q 17:7675178-7675178 6
30 COSM11059 TP53 ovary,NS,carcinoma,mucinous carcinoma c.713G>A p.C238Y 17:7674250-7674250 6
31 COSM10725 TP53 ovary,NS,carcinoma,mucinous carcinoma c.701A>G p.Y234C 17:7674262-7674262 6
32 COSM43899 TP53 ovary,NS,carcinoma,mucinous carcinoma c.434T>C p.L145P 17:7675178-7675178 6
33 COSM43690 TP53 ovary,NS,carcinoma,mucinous carcinoma c.592G>A p.E198K 17:7674939-7674939 6
34 COSM11307 TP53 ovary,NS,carcinoma,mucinous carcinoma c.643A>T p.S215C 17:7674888-7674888 6
35 COSM10659 TP53 ovary,NS,carcinoma,mucinous carcinoma c.817C>T p.R273C 17:7673803-7673803 6
36 COSM10660 TP53 ovary,NS,carcinoma,mucinous carcinoma c.818G>A p.R273H 17:7673802-7673802 6
37 COSM10801 TP53 ovary,NS,carcinoma,mucinous carcinoma c.404G>A p.C135Y 17:7675208-7675208 6
38 COSM6913 TP53 ovary,NS,carcinoma,mucinous carcinoma c.783-1G>T p.? 17:7673838-7673838 6
39 COSM43751 TP53 ovary,NS,carcinoma,mucinous carcinoma c.673-1G>A p.? 17:7674291-7674291 6
40 COSM43901 TP53 ovary,NS,carcinoma,mucinous carcinoma c.421T>C p.C141R 17:7675191-7675191 6
41 COSM10733 TP53 ovary,NS,carcinoma,mucinous carcinoma c.574C>T p.Q192* 17:7674957-7674957 6
42 COSM10731 TP53 ovary,NS,carcinoma,mucinous carcinoma c.707A>G p.Y236C 17:7674256-7674256 6
43 COSM11582 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 6
44 COSM44827 TP53 ovary,NS,carcinoma,mucinous carcinoma c.358A>G p.K120E 17:7676011-7676011 6
45 COSM11152 TP53 ovary,NS,carcinoma,mucinous carcinoma c.700T>C p.Y234H 17:7674263-7674263 6
46 COSM11066 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 6
47 COSM20645 TNK2 ovary,NS,carcinoma,mucinous carcinoma c.296G>A p.R99Q 3:195884972-195884972 6
48 COSM6904336 TNFAIP3 ovary,NS,carcinoma,adenocarcinoma c.940G>A p.V314I 6:137877210-137877210 6
49 COSM20667 TEX14 ovary,NS,carcinoma,mucinous carcinoma c.3363G>T p.K1121N 17:58574207-58574207 6
50 COSM20630 SRPK2 ovary,NS,carcinoma,mucinous carcinoma c.1438C>T p.Q480* 7:105142080-105142080 6

Expression for Ovarian Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Ovarian Mucinous Adenocarcinoma.

Pathways for Ovarian Mucinous Adenocarcinoma

GO Terms for Ovarian Mucinous Adenocarcinoma

Biological processes related to Ovarian Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 8.62 SERPINA3 MUC2

Sources for Ovarian Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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