MCID: OVR054
MIFTS: 34

Ovarian Mucinous Neoplasm

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Ovarian Mucinous Neoplasm

MalaCards integrated aliases for Ovarian Mucinous Neoplasm:

Name: Ovarian Mucinous Neoplasm 12 15
Ovarian Mucinous Tumor 12 73
Malignant Ovarian Mucinous Neoplasm 12
Malignant Ovarian Mucinous Tumor 73
Mucinous Tumor of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6067
NCIt 50 C40033 C5242
SNOMED-CT 68 189683008

Summaries for Ovarian Mucinous Neoplasm

MalaCards based summary : Ovarian Mucinous Neoplasm, also known as ovarian mucinous tumor, is related to krukenberg carcinoma and small cell carcinoma. An important gene associated with Ovarian Mucinous Neoplasm is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways is Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). The drugs Capecitabine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary and lung, and related phenotype is digestive/alimentary.

Related Diseases for Ovarian Mucinous Neoplasm

Diseases related to Ovarian Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 krukenberg carcinoma 31.1 KRT20 KRT7
2 small cell carcinoma 30.5 ENO2 KRT20 KRT7 SYP
3 teratoma 30.4 CDX2 ENO2 KRT7 SYP
4 mucinous adenocarcinoma 30.4 CDX2 KRT20 KRT7 MUC2
5 pseudomyxoma peritonei 29.4 CDX2 KRT20 KRT7 MUC2 MUC5AC MUC6
6 cystic teratoma 29.1 CDX2 ENO2 KRT20 KRT7 MUC2 MUC6
7 cystic basal cell carcinoma 11.0 KRT20 KRT7
8 seminal vesicle adenocarcinoma 11.0 KRT20 KRT7
9 transverse colon cancer 11.0 KRT20 KRT7
10 clear cell basal cell carcinoma 11.0 KRT17 KRT7
11 eyelid neoplasm 11.0 KRT20 KRT7
12 large intestine adenocarcinoma 11.0 KRT20 KRT7
13 linitis plastica 11.0 KRT20 KRT7
14 lung acinar adenocarcinoma 11.0 KRT20 KRT7
15 adenoid squamous cell carcinoma 11.0 KRT20 KRT7
16 eccrine sweat gland neoplasm 11.0 KRT20 KRT7
17 basal cell carcinoma, infundibulocystic 10.9 KRT17 KRT20
18 adenoma of the pancreas 10.9 KRT20 SYP
19 large cell acanthoma 10.9 KRT17 KRT7
20 endocervical carcinoma 10.9 KRT7 MUC6
21 endosalpingiosis 10.9 KRT7 WT1
22 pancreatic intraductal papillary-mucinous neoplasm 10.9 MUC2 MUC6
23 renal adenoma 10.9 KRT7 WT1
24 female reproductive endometrioid cancer 10.9 KRT7 WT1
25 vaginal benign neoplasm 10.9 CDX2 KRT20 KRT7
26 appendix adenocarcinoma 10.9 CDX2 KRT20 KRT7
27 vaginal adenoma 10.9 CDX2 KRT20 KRT7
28 intratubular embryonal carcinoma 10.9 KRT20 KRT7
29 vaginal tubulovillous adenoma 10.9 CDX2 KRT20 KRT7
30 glandular cystitis 10.9 CDX2 KRT20 KRT7
31 tumor of exocrine pancreas 10.9 MUC2 MUC6
32 mucinous bronchioloalveolar adenocarcinoma 10.9 CDX2 KRT20 KRT7
33 morpheaform basal cell carcinoma 10.9 KRT17 KRT20
34 gastric diffuse adenocarcinoma 10.8 CDX2 KRT20 KRT7
35 bronchiolo-alveolar adenocarcinoma 10.8 CDX2 KRT7
36 bladder adenocarcinoma 10.8 CDX2 KRT20 KRT7
37 jejunal adenocarcinoma 10.8 CDX2 KRT20 KRT7
38 chronic cystitis 10.8 CDX2 KRT20 KRT7
39 mature teratoma of the ovary 10.8 ENO2 KRT20
40 adenocarcinoma in situ 10.8 CDX2 KRT20 KRT7
41 cecum adenocarcinoma 10.8 CDX2 KRT20 KRT7
42 peritoneal serous adenocarcinoma 10.8 SYP WT1
43 malignant syringoma 10.8 KRT17 KRT20 KRT7
44 ureter small cell carcinoma 10.8 ENO2 SYP
45 malignant sertoli cell tumor 10.8 ENO2 SYP
46 cervical adenocarcinoma 10.8 CDX2 KRT20 KRT7
47 urinary bladder small cell neuroendocrine carcinoma 10.8 ENO2 SYP
48 ovary neuroendocrine neoplasm 10.8 CDX2 KRT7 SYP
49 small cell osteogenic sarcoma 10.8 ENO2 SATB2
50 auditory system cancer 10.8 ENO2 SYP

Graphical network of the top 20 diseases related to Ovarian Mucinous Neoplasm:



Diseases related to Ovarian Mucinous Neoplasm

Symptoms & Phenotypes for Ovarian Mucinous Neoplasm

MGI Mouse Phenotypes related to Ovarian Mucinous Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 CA9 CDX2 FST KRT17 MUC2 MUC5AC

Drugs & Therapeutics for Ovarian Mucinous Neoplasm

Drugs for Ovarian Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
2
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
3
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
4
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
5
Bevacizumab Approved, Investigational Phase 3 216974-75-3
6 Albumin-Bound Paclitaxel Phase 3
7 Angiogenesis Inhibitors Phase 3
8 Angiogenesis Modulating Agents Phase 3
9 Antimetabolites Phase 3
10 Antimetabolites, Antineoplastic Phase 3
11 Antimitotic Agents Phase 3
12 Antineoplastic Agents, Phytogenic Phase 3
13 CHI3L1 protein, human

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II-IV or Recurrent Stage I Epithelial Ovarian or Fallopian Tube Cancer Active, not recruiting NCT01081262 Phase 3 Capecitabine;Carboplatin;Oxaliplatin;Paclitaxel
2 YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy Terminated NCT00899093

Search NIH Clinical Center for Ovarian Mucinous Neoplasm

Genetic Tests for Ovarian Mucinous Neoplasm

Anatomical Context for Ovarian Mucinous Neoplasm

MalaCards organs/tissues related to Ovarian Mucinous Neoplasm:

41
Ovary, Lung

Publications for Ovarian Mucinous Neoplasm

Articles related to Ovarian Mucinous Neoplasm:

# Title Authors Year
1
A case report of an incidental Brenner tumor found after resection of a large ovarian mucinous neoplasm. ( 29960208 )
2018
2
FOXA1 is expressed in ovarian mucinous neoplasms. ( 28238418 )
2017
3
Borderline ovarian mucinous neoplasm recurring as small cell carcinoma of hypercalcemic type: evidence for an epithelial histogenesis and relationship with ovarian mucinous tumors for this enigmatic neoplasm. ( 21623206 )
2011
4
Emergence of CA125 immunoreactivity in recurrent or metastatic primary ovarian mucinous neoplasms of the intestinal type. ( 21836488 )
2011
5
Cytoplasmic and stromal expression of laminin I^ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. ( 21042753 )
2010
6
Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms. ( 19694825 )
2009
7
Intestinal type and endocervical-like ovarian mucinous neoplasms are immunophenotypically distinct entities. ( 18665037 )
2008
8
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. ( 15722802 )
2005
9
Expression of matrix metalloproteinases and related tissue inhibitors in the cyst fluids of ovarian mucinous neoplasms. ( 10926788 )
2000
10
An immunohistochemical study of p53 protein in ovarian mucinous neoplasms. ( 8912347 )
1996

Variations for Ovarian Mucinous Neoplasm

Expression for Ovarian Mucinous Neoplasm

Search GEO for disease gene expression data for Ovarian Mucinous Neoplasm.

Pathways for Ovarian Mucinous Neoplasm

Pathways related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.84 MUC2 MUC5AC MUC6

GO Terms for Ovarian Mucinous Neoplasm

Cellular components related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC2 MUC5AC MUC6

Biological processes related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.54 MUC2 MUC5AC MUC6
2 cornification GO:0070268 9.5 KRT17 KRT20 KRT7
3 intermediate filament organization GO:0045109 9.26 KRT17 KRT20
4 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC6
5 O-glycan processing GO:0016266 9.13 MUC2 MUC5AC MUC6
6 positive regulation of hair follicle development GO:0051798 8.62 FST KRT17

Sources for Ovarian Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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