MCID: OVR054
MIFTS: 37

Ovarian Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mucinous Neoplasm

MalaCards integrated aliases for Ovarian Mucinous Neoplasm:

Name: Ovarian Mucinous Neoplasm 12 15
Ovarian Mucinous Tumor 12 73
Malignant Ovarian Mucinous Neoplasm 12
Malignant Ovarian Mucinous Tumor 73
Mucinous Tumor of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6067
NCIt 50 C40033 C5242

Summaries for Ovarian Mucinous Neoplasm

Disease Ontology : 12 An ovary epithelial cancer that is characterized by the presence of mucin.

MalaCards based summary : Ovarian Mucinous Neoplasm, also known as ovarian mucinous tumor, is related to small cell carcinoma and krukenberg carcinoma. An important gene associated with Ovarian Mucinous Neoplasm is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Diseases of glycosylation and Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC). The drugs Capecitabine and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and kidney, and related phenotype is digestive/alimentary.

Related Diseases for Ovarian Mucinous Neoplasm

Diseases related to Ovarian Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.4 KRT20 KRT7 SYP
2 krukenberg carcinoma 30.1 KRT20 KRT7
3 teratoma 30.1 CDX2 KRT7 SYP
4 ovarian mucinous adenocarcinoma 30.0 CDX2 KRT20 KRT7 MUC2
5 mucinous adenocarcinoma 30.0 CDX2 KRT20 KRT7 MUC2
6 pseudomyxoma peritonei 29.9 CDX2 KRT20 KRT7 MUC2 MUC5AC MUC6
7 cystadenoma 29.8 KRT20 KRT7 MUC2 MUC6 SYP
8 cystic teratoma 29.7 CDX2 KRT20 KRT7 MUC2 MUC6 SYP
9 ovarian mucinous malignant adenofibroma 11.3
10 nasal cavity cancer 10.3 CDX2 KRT7
11 nasal cavity adenocarcinoma 10.3 CDX2 KRT7
12 paget disease, extramammary 10.3 KRT20 KRT7
13 bladder lymphoma 10.3 KRT20 KRT7
14 papillary serous adenocarcinoma 10.3 KRT20 KRT7
15 bile duct adenoma 10.3 KRT20 KRT7
16 adenoid squamous cell carcinoma 10.3 KRT20 KRT7
17 adenomyoma 10.3 KRT7 MUC6
18 intratubular embryonal carcinoma 10.3 KRT20 KRT7
19 endocervical carcinoma 10.3 KRT7 MUC6
20 morpheaform basal cell carcinoma 10.3 KRT17 KRT20
21 bowen's disease 10.3 KRT17 KRT7
22 seminal vesicle tumor 10.3 KRT7 SYP
23 gastric squamous cell carcinoma 10.3 KRT7 SYP
24 pulmonary sclerosing hemangioma 10.3 KRT7 SYP
25 peritoneum cancer 10.3 KRT7 WT1
26 female reproductive endometrioid cancer 10.3 KRT7 WT1
27 kidney benign neoplasm 10.3 KRT7 WT1
28 adenomatoid tumor 10.3 KRT7 WT1
29 metanephric adenoma 10.3 KRT7 WT1
30 urethral diverticulum 10.3 KRT7 WT1
31 chronic cholangitis 10.3 CDX2 MUC2
32 vaginal benign neoplasm 10.3 CDX2 KRT20
33 vaginal adenoma 10.3 CDX2 KRT20
34 cystic basal cell carcinoma 10.3 KRT20 KRT7
35 vaginal tubulovillous adenoma 10.3 CDX2 KRT20
36 kidney clear cell sarcoma 10.3 SATB2 WT1
37 clear cell basal cell carcinoma 10.3 KRT17 KRT7
38 male reproductive organ benign neoplasm 10.3 SYP WT1
39 rhabdoid cancer 10.3 SYP WT1
40 venous hemangioma 10.3 SYP WT1
41 cauda equina neoplasm 10.3 SYP WT1
42 ovarian small cell carcinoma 10.3 SYP WT1
43 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
44 transverse colon cancer 10.3 KRT20 KRT7
45 desmoplastic small round cell tumor 10.3 SYP WT1
46 malignant syringoma 10.3 KRT20 KRT7
47 cervical polyp 10.3 CDX2 MUC6
48 ovarian large-cell neuroendocrine carcinoma 10.2 KRT20 SYP
49 cervical adenocarcinoma 10.2 CDX2 KRT20 KRT7
50 papillary transitional carcinoma 10.2 KRT20 KRT7

Graphical network of the top 20 diseases related to Ovarian Mucinous Neoplasm:



Diseases related to Ovarian Mucinous Neoplasm

Symptoms & Phenotypes for Ovarian Mucinous Neoplasm

MGI Mouse Phenotypes related to Ovarian Mucinous Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 CA9 CDX2 FST KRT17 MUC2 MUC5AC

Drugs & Therapeutics for Ovarian Mucinous Neoplasm

Drugs for Ovarian Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
4
Bevacizumab Approved, Investigational Phase 3 216974-75-3
5
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
6 Albumin-Bound Paclitaxel Phase 3
7 Antineoplastic Agents, Phytogenic Phase 3
8 Antimitotic Agents Phase 3
9 Antimetabolites Phase 3
10 Angiogenesis Modulating Agents Phase 3
11 Angiogenesis Inhibitors Phase 3
12 Antimetabolites, Antineoplastic Phase 3
13 CHI3L1 protein, human

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II-IV or Recurrent Stage I Epithelial Ovarian or Fallopian Tube Cancer Active, not recruiting NCT01081262 Phase 3 Capecitabine;Carboplatin;Oxaliplatin;Paclitaxel
2 Physical Activity Monitored by Fitbit Charge 2 in Improving Quality of Life in Participants With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Recruiting NCT03685695 Phase 2
3 YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy Terminated NCT00899093

Search NIH Clinical Center for Ovarian Mucinous Neoplasm

Genetic Tests for Ovarian Mucinous Neoplasm

Anatomical Context for Ovarian Mucinous Neoplasm

MalaCards organs/tissues related to Ovarian Mucinous Neoplasm:

41
Ovary, Lung, Kidney, Pancreas, Thymus, Small Intestine, Appendix

Publications for Ovarian Mucinous Neoplasm

Articles related to Ovarian Mucinous Neoplasm:

# Title Authors Year
1
A case report of an incidental Brenner tumor found after resection of a large ovarian mucinous neoplasm. ( 29960208 )
2018
2
Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor. ( 30194204 )
2018
3
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision? ( 25473748 )
2015
4
Borderline ovarian mucinous neoplasm recurring as small cell carcinoma of hypercalcemic type: evidence for an epithelial histogenesis and relationship with ovarian mucinous tumors for this enigmatic neoplasm. ( 21623206 )
2011
5
Nuclear morphometry and AgNOR quantification: computerized image analysis on ovarian mucinous tumor imprints. ( 18630841 )
2008
6
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. ( 15722802 )
2005
7
Anaplastic nodules in an ovarian mucinous tumor. Case report and literature review. ( 10215434 )
1998
8
Fibrosarcoma arising in an ovarian mucinous tumor: a case report. ( 11578409 )
1994
9
Ovarian mucinous tumor with mural nodules of anaplastic carcinoma. ( 2477315 )
1989

Variations for Ovarian Mucinous Neoplasm

Expression for Ovarian Mucinous Neoplasm

Search GEO for disease gene expression data for Ovarian Mucinous Neoplasm.

Pathways for Ovarian Mucinous Neoplasm

GO Terms for Ovarian Mucinous Neoplasm

Cellular components related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC2 MUC5AC MUC6

Biological processes related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT17 KRT20 KRT7
2 intermediate filament organization GO:0045109 9.37 KRT17 KRT20
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.33 MUC2 MUC5AC MUC6
4 maintenance of gastrointestinal epithelium GO:0030277 9.26 MUC2 MUC6
5 positive regulation of hair follicle development GO:0051798 8.96 FST KRT17
6 O-glycan processing GO:0016266 8.8 MUC2 MUC5AC MUC6

Sources for Ovarian Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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