MCID: OVR054
MIFTS: 30

Ovarian Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mucinous Neoplasm

MalaCards integrated aliases for Ovarian Mucinous Neoplasm:

Name: Ovarian Mucinous Neoplasm 12 15
Ovarian Mucinous Tumor 12 72
Malignant Ovarian Mucinous Neoplasm 12
Malignant Ovarian Mucinous Tumor 72
Mucinous Tumor of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6067
NCIt 50 C40033 C5242
UMLS 72 C1335168 C1518233

Summaries for Ovarian Mucinous Neoplasm

Disease Ontology : 12 An ovary epithelial cancer that is characterized by the presence of mucin.

MalaCards based summary : Ovarian Mucinous Neoplasm, also known as ovarian mucinous tumor, is related to teratoma and mucinous adenofibroma. An important gene associated with Ovarian Mucinous Neoplasm is KRT7 (Keratin 7). The drugs Oxaliplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and lung, and related phenotype is limbs/digits/tail.

Related Diseases for Ovarian Mucinous Neoplasm

Diseases related to Ovarian Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.8 KRT7 CDX2
2 mucinous adenofibroma 30.6 KRT7 CDX2
3 small cell carcinoma 30.6 KRT7 KRT20
4 krukenberg carcinoma 30.3 KRT7 KRT20
5 mucinous cystadenocarcinoma 30.2 KRT7 KRT20
6 appendix adenocarcinoma 30.1 KRT7 KRT20 CDX2
7 cystadenoma 30.0 MUC6 KRT7 KRT20
8 polycystic liver disease 1 with or without kidney cysts 29.9 KRT7 KRT20
9 gastrointestinal system cancer 29.9 KRT7 KRAS CDX2
10 ovarian mucinous adenocarcinoma 29.9 KRT7 KRT20 CDX2
11 cervical adenocarcinoma 29.8 KRT7 KRT20 CDX2
12 carcinosarcoma 29.8 KRT7 KRAS
13 villous adenoma 29.5 KRT20 KRAS CDX2
14 cystic teratoma 29.4 MUC6 KRT7 KRT20 CDX2
15 mucinous adenocarcinoma 29.4 KRT7 KRT20 KRAS CDX2
16 colorectal adenocarcinoma 29.4 KRT7 KRT20 KRAS CDX2
17 ovarian brenner tumor 29.2 PAX8 KRT7 KRT20
18 gastric adenocarcinoma 29.1 KRT7 KRT20 KRAS CDX2
19 appendix cancer 29.1 MUC6 KRT7 KRT20 CDX2
20 lung cancer susceptibility 3 29.0 KRT7 KRT20 KRAS CDX2
21 pseudomyxoma peritonei 28.9 MUC6 KRT7 KRT20 KRAS CDX2
22 ovarian mucinous malignant adenofibroma 11.4
23 ovary neuroendocrine neoplasm 10.5 KRT7 CDX2
24 anus adenocarcinoma 10.5 KRT7 CDX2
25 epithelial predominant wilms' tumor 10.5 KRT7 CDX2
26 nasal cavity cancer 10.5 KRT7 CDX2
27 adenosquamous carcinoma 10.4 KRT7 KRAS
28 hidradenocarcinoma 10.4 KRT7 CDX2
29 anus cancer 10.4 KRT7 CDX2
30 solid adenocarcinoma with mucin production 10.4 MUC6 KRT7
31 mucinous intrahepatic cholangiocarcinoma 10.4 MUC6 CDX2
32 cervical polyp 10.3 MUC6 CDX2
33 adenomyoma 10.3 MUC6 KRT7
34 alveoli adenoma 10.3 KRT7 KRAS
35 mucinous tubular and spindle renal cell carcinoma 10.3 MUC6 KRT7
36 cystic basal cell carcinoma 10.3 KRT7 KRT20
37 malignant syringoma 10.3 KRT7 KRT20
38 transverse colon cancer 10.3 KRT7 KRT20
39 tubular adenocarcinoma 10.3 KRT20 CDX2
40 seminal vesicle adenocarcinoma 10.3 KRT7 KRT20
41 eyelid carcinoma 10.3 KRT7 KRT20
42 papillary transitional carcinoma 10.3 KRT7 KRT20
43 superior mesenteric artery syndrome 10.3 MUC6 CDX2
44 small cell carcinoma of the bladder 10.3 KRT7 KRT20
45 lung acinar adenocarcinoma 10.3 KRT7 KRT20
46 linitis plastica 10.3 KRT7 KRT20
47 vaginal tubulovillous adenoma 10.3 KRT20 CDX2
48 vaginal adenoma 10.3 KRT20 CDX2
49 large intestine adenocarcinoma 10.3 KRT7 KRT20
50 vaginal benign neoplasm 10.3 KRT20 CDX2

Graphical network of the top 20 diseases related to Ovarian Mucinous Neoplasm:



Diseases related to Ovarian Mucinous Neoplasm

Symptoms & Phenotypes for Ovarian Mucinous Neoplasm

MGI Mouse Phenotypes related to Ovarian Mucinous Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 CDX2 KRAS PAX8 SATB2

Drugs & Therapeutics for Ovarian Mucinous Neoplasm

Drugs for Ovarian Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Bevacizumab Approved, Investigational Phase 3 216974-75-3
4
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6 Immunoglobulin G Phase 3
7 Antineoplastic Agents, Phytogenic Phase 3
8 Mitogens Phase 3
9 Angiogenesis Inhibitors Phase 3
10 Angiogenesis Modulating Agents Phase 3
11 Tubulin Modulators Phase 3
12 Albumin-Bound Paclitaxel Phase 3
13 Antineoplastic Agents, Immunological Phase 3
14 Antibodies Phase 3
15 Immunoglobulins Phase 3
16 Antimitotic Agents Phase 3
17 Endothelial Growth Factors Phase 3
18 Antibodies, Monoclonal Phase 3
19 Antimetabolites Phase 3
20 Immunologic Factors Phase 3
21 Antimetabolites, Antineoplastic Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A GCIG Intergroup Multicenter Phase III Trial of Open Label Carboplatin and Paclitaxel +/- NCI-Supplied Agent: Bevacizumab (NSC #704865) Compared With Oxaliplatin and Capecitabine +/- Bevacizumab as First Line Chemotherapy in Patients With Mucinous Epithelial Ovarian or Fallopian Tube Cancer (MEOC) Active, not recruiting NCT01081262 Phase 3 Capecitabine;Carboplatin;Oxaliplatin;Paclitaxel

Search NIH Clinical Center for Ovarian Mucinous Neoplasm

Genetic Tests for Ovarian Mucinous Neoplasm

Anatomical Context for Ovarian Mucinous Neoplasm

MalaCards organs/tissues related to Ovarian Mucinous Neoplasm:

41
Ovary, Endothelial, Lung, Colon, Uterus, Appendix

Publications for Ovarian Mucinous Neoplasm

Articles related to Ovarian Mucinous Neoplasm:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Preoperative Optimization and Choreographed Physiological Evaluation for Resection of Giant Abdominal Neoplasm: A Case Report. 38
31021824 2019
2
Ovarian mucinous cystic tumor associated with sarcomatous mural nodule and benign Brenner tumor: A case report and literature review. 38
30653119 2019
3
Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor. 38
30194204 2018
4
Improvement of hyperandrogenism, oligo-ovulation, and ovarian morphology in a patient with polycystic ovary syndrome: possible role of ovarian wedge resection. 38
29298536 2018
5
Mucinous Carcinomatosis: A Rare Association between an Ovarian Tumor and an E-GIST. 38
29593930 2018
6
A case report of an incidental Brenner tumor found after resection of a large ovarian mucinous neoplasm. 38
29960208 2018
7
Giant mucinous ovarian borderline tumor. A good lesson from an asymptomatic case. 38
30071377 2018
8
Dual Immunostain With SATB2 and CK20 Differentiates Appendiceal Mucinous Neoplasms From Ovarian Mucinous Neoplasms. 38
28340228 2017
9
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome. 38
27550049 2017
10
Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis. 38
27872782 2016
11
Osteosarcoma as Malignant Mural Nodule in Ovarian Mucinous Neoplasms of Intestinal Type: Report of 2 Cases. 38
25760909 2015
12
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision? 38
25473748 2015
13
Coexistence of mature cystic teratoma and adenocarcinoma in situ within atypical proliferative mucinous tumour of ovary--a case report of 35-year-old woman. 38
26050362 2015
14
Mucinous borderline ovarian tumor with ascites. 38
25518783 2014
15
Unique features and insights from mucinous tumors of ovary in childhood: clinicopathological study of 15 cases including four premenarchal cases. 38
24575832 2014
16
An evaluation of the morphologic features of low-grade mucinous neoplasms of the appendix metastatic in the ovary, and comparison with primary ovarian mucinous tumors. 38
24300528 2014
17
Association of pancreatic adenocarcinoma up-regulated factor expression in ovarian mucinous adenocarcinoma with poor prognosis. 38
25197383 2014
18
Follistatin is a novel biomarker for lung adenocarcinoma in humans. 38
25347573 2014
19
Multiple genital tract tumors and mucinous adenocarcinoma of colon in a woman with Peutz-Jeghers syndrome: a case report and review of literatures. 38
25120832 2014
20
Trigeminal neuralgia as the first clinical manifestation of anti-hu paraneoplastic syndrome induced by a borderline ovarian mucinous tumor. 38
24575026 2014
21
Is routine appendectomy at the time of primary surgery for mucinous ovarian neoplasms beneficial? 38
23835504 2013
22
Increased expression of OCIA domain containing 2 during stepwise progression of ovarian mucinous tumor. 38
22726067 2012
23
Low-grade appendiceal mucinous neoplasm with disseminated peritoneal adenomucinosis involving the uterus, mimicking primary mucinous endometrial adenocarcinoma: a case report. 38
21733040 2011
24
Borderline ovarian mucinous neoplasm recurring as small cell carcinoma of hypercalcemic type: evidence for an epithelial histogenesis and relationship with ovarian mucinous tumors for this enigmatic neoplasm. 38
21623206 2011
25
Serum CA19.9 levels are commonly elevated in primary ovarian mucinous tumours but cannot be used to predict the histological subtype. 38
20154039 2010
26
Intestinal type and endocervical-like ovarian mucinous neoplasms are immunophenotypically distinct entities. 38
18665037 2008
27
Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor. 38
18670351 2008
28
Nuclear morphometry and AgNOR quantification: computerized image analysis on ovarian mucinous tumor imprints. 38
18630841 2008
29
A huge ovarian mucinous cystadenoma in a 14-year-old premenarchal girl: review on ovarian mucinous tumor in premenarchal girls. 38
18312801 2008
30
Ovarian mucinous tumor arising in mature cystic teratoma associated with pseudomyxoma peritonei: a case with possible respiratory epithelial differentiation. 38
18156973 2008
31
Malignant or borderline mucinous cystic neoplasms have a larger number of loculi than mucinous cystadenoma: a retrospective study with MR. 38
17659568 2007
32
Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. 38
17527072 2007
33
Establishment and characterization of a human ovarian sarcomatoid carcinoma cell line BUPH:OVSC. 38
16174236 2005
34
Metastatic duodenal carcinoma simulating primary mucinous tumor of the ovary. 38
15300447 2005
35
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. 38
15722802 2005
36
Mucinous tumors of the ovary: a review. 38
15626914 2005
37
Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. 38
15297962 2004
38
[Pseudomyxoma peritonei: report of 11 cases with a literature review]. 38
12622904 2002
39
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection. 38
11727259 2001
40
WT1 is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms. 38
11488072 2001
41
A rare case of pseudomyxoma peritonei presenting an unusual inguinal hernia and splenic metastasis. 38
11446896 2001
42
Mucinous cystadenoma coexisting with stromal tumor with minor sex-cord elements of the ovary: a case report. 38
11306755 2001
43
[Peritoneal pseudomyxoma associated with an ovarian and appendicular mucinous tumor]. 38
10089686 1999
44
[Ovarian mucinous tumor of gastric and intestinal type associated with Peutz-Jeghers syndrome: in situ hybridization study of apomucin gene transcripts]. 38
10051919 1998
45
Anaplastic nodules in an ovarian mucinous tumor. Case report and literature review. 38
10215434 1998
46
Identical, unique p53 mutations in a primary ovarian mucinous adenocarcinoma and a synchronous contralateral ovarian mucinous tumor of low malignant potential suggest a common clonal origin. 38
9158713 1997
47
Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. 38
8786207 1996
48
Fibrosarcoma arising in an ovarian mucinous tumor: a case report. 38
11578409 1994
49
Rhabdomyosarcoma coexistent with ovarian mucinous cystadenocarcinoma: a case report. 38
1563909 1992
50
Ovarian mucinous tumor with mural nodules of anaplastic carcinoma. 38
2477315 1989

Variations for Ovarian Mucinous Neoplasm

Expression for Ovarian Mucinous Neoplasm

Search GEO for disease gene expression data for Ovarian Mucinous Neoplasm.

Pathways for Ovarian Mucinous Neoplasm

GO Terms for Ovarian Mucinous Neoplasm

Biological processes related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.62 MUC6 KRAS

Sources for Ovarian Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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