MCID: OVR054
MIFTS: 34

Ovarian Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Mucinous Neoplasm

MalaCards integrated aliases for Ovarian Mucinous Neoplasm:

Name: Ovarian Mucinous Neoplasm 12 15
Ovarian Mucinous Tumor 12 71
Malignant Ovarian Mucinous Neoplasm 12
Malignant Ovarian Mucinous Tumor 71
Mucinous Tumor of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6067
NCIt 49 C40033 C5242
UMLS 71 C1335168 C1518233

Summaries for Ovarian Mucinous Neoplasm

Disease Ontology : 12 An ovary epithelial cancer that is characterized by the presence of mucin.

MalaCards based summary : Ovarian Mucinous Neoplasm, also known as ovarian mucinous tumor, is related to ovarian brenner tumor and adenoma. An important gene associated with Ovarian Mucinous Neoplasm is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are MNAR-PELP1 and Estrogen Receptor Interaction and CD209 (DC-SIGN) signaling. The drugs Oxaliplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary, colon and lung, and related phenotype is Reduced mammosphere formation.

Related Diseases for Ovarian Mucinous Neoplasm

Diseases related to Ovarian Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
# Related Disease Score Top Affiliating Genes
1 ovarian brenner tumor 30.6 KRT7 KRT20
2 adenoma 30.0 MUC5AC KRT7 KRAS CDX2
3 small cell carcinoma 30.0 KRT7 KRT20 KRAS CDX2
4 ovarian mucinous adenocarcinoma 30.0 MUC5AC KRT7 KRT20 CDX2
5 endometrioid ovary carcinoma 29.8 KRAS HRAS
6 cystadenoma 29.7 MUC5AC KRT7 KRT20 CEACAM5
7 mucinous cystadenocarcinoma 29.7 KRT7 KRT20 CEACAM5
8 polycystic liver disease 1 with or without kidney cysts 29.7 KRT7 KRT20 CEACAM5
9 mucinous adenofibroma 29.7 KRT7 CEACAM5 CDX2
10 neuroendocrine carcinoma 29.7 KRT7 KRT20 CEACAM5
11 gastrointestinal carcinoma 29.6 KRT20 CEACAM5 CDX2
12 papillary adenocarcinoma 29.5 KRT7 KRAS CEACAM5
13 mature teratoma 29.4 KRT7 KRAS CEACAM5
14 cervical adenocarcinoma 29.4 KRT7 KRT20 CEACAM5 CDX2
15 cystadenocarcinoma 29.1 MUC5AC KRT7 HRAS CEACAM5
16 carcinosarcoma 29.1 U2AF1 PAX8 KRT7 KRAS HRAS
17 pseudomyxoma peritonei 29.0 MUC5AC KRT7 KRT20 KRAS CEACAM5 CDX2
18 krukenberg carcinoma 28.9 SATB2 KRT7 KRT20 CEACAM5 CDX2
19 teratoma 28.9 KRT7 KRT20 KRAS CEACAM5 CDX2
20 cystic teratoma 28.8 MUC5AC KRT7 KRT20 KRAS CEACAM5 CDX2
21 mucinous adenocarcinoma 28.7 MUC5AC KRT7 KRT20 KRAS CEACAM5 CDX2
22 pancreatic adenocarcinoma 28.7 U2AF1 PSCA MUC5AC KRAS HRAS CDX2
23 ovarian cystadenocarcinoma 28.7 PAX8 KRAS HRAS CEACAM5
24 adenocarcinoma 28.7 KRT7 KRT20 KRAS HRAS CEACAM5 CDX2
25 villous adenoma 28.2 MUC5AC KRT20 KRAS HRAS CEACAM5 CDX2
26 appendix adenocarcinoma 28.1 SATB2 KRT7 KRT20 KRAS HRAS CEACAM5
27 colorectal adenocarcinoma 28.1 SATB2 KRT7 KRT20 KRAS HRAS CEACAM5
28 endometrial cancer 28.1 PAX8 KRT7 KRT20 KRAS HRAS CEACAM5
29 gastric adenocarcinoma 27.7 PSCA KRT7 KRT20 KRAS HRAS CEACAM5
30 pancreatic cancer 27.5 PSCA MUC5AC KRT7 KRT20 KRAS HRAS
31 lung cancer susceptibility 3 27.5 U2AF1 MUC5AC KRT7 KRT20 KRAS HRAS
32 appendix cancer 27.4 SATB2 MUC5AC KRT7 KRT20 KRAS HRAS
33 ovarian cancer 26.7 PAX8 OCIAD2 OCIAD1 MUC5AC KRT7 KRT20
34 ovarian mucinous malignant adenofibroma 11.4
35 bladder signet ring cell adenocarcinoma 10.5 KRT7 CDX2
36 ovary neuroendocrine neoplasm 10.5 KRT7 CDX2
37 anal canal paget's disease 10.5 KRT7 CDX2
38 adenosquamous colon carcinoma 10.5 KRT7 CDX2
39 anus adenocarcinoma 10.5 KRT7 CDX2
40 pancreatic serous cystadenocarcinoma 10.5 KRT7 KRT20
41 rectum neuroendocrine neoplasm 10.5 KRT7 CDX2
42 intrahepatic bile duct adenoma 10.5 KRT7 KRT20
43 bile duct adenoma 10.5 KRT7 KRT20
44 ovarian large-cell neuroendocrine carcinoma 10.4 KRT7 KRT20
45 atrophic vulva 10.4 KRT7 KRT20
46 small cell carcinoma of the bladder 10.4 KRT7 KRT20
47 urinary bladder small cell neuroendocrine carcinoma 10.4 KRT7 KRT20
48 eyelid carcinoma 10.4 KRT7 KRT20
49 intratubular embryonal carcinoma 10.4 KRT7 KRT20
50 jejunal neoplasm 10.4 KRT7 KRT20

Graphical network of the top 20 diseases related to Ovarian Mucinous Neoplasm:



Diseases related to Ovarian Mucinous Neoplasm

Symptoms & Phenotypes for Ovarian Mucinous Neoplasm

GenomeRNAi Phenotypes related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 HRAS KRAS KRT7 MUC5AC OCIAD1 PAX8

Drugs & Therapeutics for Ovarian Mucinous Neoplasm

Drugs for Ovarian Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599 43805
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Bevacizumab Approved, Investigational Phase 3 216974-75-3
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
6 Antibodies, Monoclonal Phase 3
7 Antineoplastic Agents, Immunological Phase 3
8 Endothelial Growth Factors Phase 3
9 Angiogenesis Inhibitors Phase 3
10 Immunologic Factors Phase 3
11 Mitogens Phase 3
12 Antimitotic Agents Phase 3
13 Albumin-Bound Paclitaxel Phase 3
14 Immunoglobulin G Phase 3
15 Antimetabolites Phase 3
16 Immunoglobulins Phase 3
17 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A GCIG Intergroup Multicenter Phase III Trial of Open Label Carboplatin and Paclitaxel +/- NCI-Supplied Agent: Bevacizumab (NSC #704865) Compared With Oxaliplatin and Capecitabine +/- Bevacizumab as First Line Chemotherapy in Patients With Mucinous Epithelial Ovarian or Fallopian Tube Cancer (MEOC) Active, not recruiting NCT01081262 Phase 3 Capecitabine;Carboplatin;Oxaliplatin;Paclitaxel

Search NIH Clinical Center for Ovarian Mucinous Neoplasm

Genetic Tests for Ovarian Mucinous Neoplasm

Anatomical Context for Ovarian Mucinous Neoplasm

MalaCards organs/tissues related to Ovarian Mucinous Neoplasm:

40
Ovary, Colon, Lung, Thyroid, Appendix, Kidney, Uterus

Publications for Ovarian Mucinous Neoplasm

Articles related to Ovarian Mucinous Neoplasm:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Primary signet ring cell carcinoma with neuroendocrine differentiation arising in mucinous borderline tumor of the ovary. 61
31872017 2020
2
A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review. 61
31488447 2019
3
Preoperative Optimization and Choreographed Physiological Evaluation for Resection of Giant Abdominal Neoplasm: A Case Report. 61
31021824 2019
4
Ovarian mucinous cystic tumor associated with sarcomatous mural nodule and benign Brenner tumor: A case report and literature review. 61
30653119 2019
5
Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor. 61
30194204 2018
6
Improvement of hyperandrogenism, oligo-ovulation, and ovarian morphology in a patient with polycystic ovary syndrome: possible role of ovarian wedge resection. 61
29298536 2018
7
Mucinous Carcinomatosis: A Rare Association between an Ovarian Tumor and an E-GIST. 61
29593930 2018
8
A case report of an incidental Brenner tumor found after resection of a large ovarian mucinous neoplasm. 61
29960208 2018
9
Giant mucinous ovarian borderline tumor. A good lesson from an asymptomatic case. 61
30071377 2018
10
Dual Immunostain With SATB2 and CK20 Differentiates Appendiceal Mucinous Neoplasms From Ovarian Mucinous Neoplasms. 61
28340228 2017
11
A Pyloric Gland-Phenotype Ovarian Mucinous Tumor Resembling Lobular Endocervical Glandular Hyperplasia in a Patient with Peutz-Jeghers Syndrome. 61
27550049 2017
12
Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis. 61
27872782 2016
13
Osteosarcoma as Malignant Mural Nodule in Ovarian Mucinous Neoplasms of Intestinal Type: Report of 2 Cases. 61
25760909 2015
14
Coexistence of mature cystic teratoma and adenocarcinoma in situ within atypical proliferative mucinous tumour of ovary--a case report of 35-year-old woman. 61
26050362 2015
15
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision? 61
25473748 2015
16
Mucinous borderline ovarian tumor with ascites. 61
25518783 2014
17
Unique features and insights from mucinous tumors of ovary in childhood: clinicopathological study of 15 cases including four premenarchal cases. 61
24575832 2014
18
An evaluation of the morphologic features of low-grade mucinous neoplasms of the appendix metastatic in the ovary, and comparison with primary ovarian mucinous tumors. 61
24300528 2014
19
Association of pancreatic adenocarcinoma up-regulated factor expression in ovarian mucinous adenocarcinoma with poor prognosis. 61
25197383 2014
20
Follistatin is a novel biomarker for lung adenocarcinoma in humans. 61
25347573 2014
21
Multiple genital tract tumors and mucinous adenocarcinoma of colon in a woman with Peutz-Jeghers syndrome: a case report and review of literatures. 61
25120832 2014
22
Trigeminal neuralgia as the first clinical manifestation of anti-hu paraneoplastic syndrome induced by a borderline ovarian mucinous tumor. 61
24575026 2014
23
Is routine appendectomy at the time of primary surgery for mucinous ovarian neoplasms beneficial? 61
23835504 2013
24
Increased expression of OCIA domain containing 2 during stepwise progression of ovarian mucinous tumor. 61
22726067 2012
25
Low-grade appendiceal mucinous neoplasm with disseminated peritoneal adenomucinosis involving the uterus, mimicking primary mucinous endometrial adenocarcinoma: a case report. 61
21733040 2011
26
Borderline ovarian mucinous neoplasm recurring as small cell carcinoma of hypercalcemic type: evidence for an epithelial histogenesis and relationship with ovarian mucinous tumors for this enigmatic neoplasm. 61
21623206 2011
27
Serum CA19.9 levels are commonly elevated in primary ovarian mucinous tumours but cannot be used to predict the histological subtype. 61
20154039 2010
28
Intestinal type and endocervical-like ovarian mucinous neoplasms are immunophenotypically distinct entities. 61
18665037 2008
29
Primary ovarian mucinous tumors with signet ring cells: report of 3 cases with discussion of so-called primary Krukenberg tumor. 61
18670351 2008
30
Nuclear morphometry and AgNOR quantification: computerized image analysis on ovarian mucinous tumor imprints. 61
18630841 2008
31
A huge ovarian mucinous cystadenoma in a 14-year-old premenarchal girl: review on ovarian mucinous tumor in premenarchal girls. 61
18312801 2008
32
Ovarian mucinous tumor arising in mature cystic teratoma associated with pseudomyxoma peritonei: a case with possible respiratory epithelial differentiation. 61
18156973 2008
33
Malignant or borderline mucinous cystic neoplasms have a larger number of loculi than mucinous cystadenoma: a retrospective study with MR. 61
17659568 2007
34
Ovarian mucinous tumors associated with mature cystic teratomas: morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. 61
17527072 2007
35
Establishment and characterization of a human ovarian sarcomatoid carcinoma cell line BUPH:OVSC. 61
16174236 2005
36
Metastatic duodenal carcinoma simulating primary mucinous tumor of the ovary. 61
15300447 2005
37
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. 61
15722802 2005
38
Mucinous tumors of the ovary: a review. 61
15626914 2005
39
Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. 61
15297962 2004
40
[Pseudomyxoma peritonei: report of 11 cases with a literature review]. 61
12622904 2002
41
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection. 61
11727259 2001
42
WT1 is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms. 61
11488072 2001
43
A rare case of pseudomyxoma peritonei presenting an unusual inguinal hernia and splenic metastasis. 61
11446896 2001
44
Mucinous cystadenoma coexisting with stromal tumor with minor sex-cord elements of the ovary: a case report. 61
11306755 2001
45
[Peritoneal pseudomyxoma associated with an ovarian and appendicular mucinous tumor]. 61
10089686 1999
46
[Ovarian mucinous tumor of gastric and intestinal type associated with Peutz-Jeghers syndrome: in situ hybridization study of apomucin gene transcripts]. 61
10051919 1998
47
Anaplastic nodules in an ovarian mucinous tumor. Case report and literature review. 61
10215434 1998
48
Identical, unique p53 mutations in a primary ovarian mucinous adenocarcinoma and a synchronous contralateral ovarian mucinous tumor of low malignant potential suggest a common clonal origin. 61
9158713 1997
49
Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma. 61
8786207 1996
50
Fibrosarcoma arising in an ovarian mucinous tumor: a case report. 61
11578409 1994

Variations for Ovarian Mucinous Neoplasm

Expression for Ovarian Mucinous Neoplasm

Search GEO for disease gene expression data for Ovarian Mucinous Neoplasm.

Pathways for Ovarian Mucinous Neoplasm

Pathways related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 KRAS HRAS
2 10.5 KRAS HRAS
3 10.26 KRAS HRAS
4 9.74 KRAS HRAS

GO Terms for Ovarian Mucinous Neoplasm

Biological processes related to Ovarian Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 KRAS HRAS
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC5AC KRAS HRAS
3 response to isolation stress GO:0035900 8.62 KRAS HRAS

Sources for Ovarian Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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