Ovarian Primitive Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

IMPROVED

Name: Ovarian Primitive Germ Cell Tumor ¹¹ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5351

NCIt ⁴⁹ C39986

UMLS ⁷¹ C1518727

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Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology: ¹¹ A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary: Ovarian Primitive Germ Cell Tumor is related to ovarian mixed germ cell neoplasm and ovarian endodermal sinus tumor. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)

#	Related Disease	Score	Top Affiliating Genes
1	ovarian mixed germ cell neoplasm	32.1	PAX8 AFP
2	ovarian endodermal sinus tumor	29.7	SALL4 POU5F1 PAX8 NKX2-5 NAPSA KRT7
3	polyembryoma of the ovary	11.4
4	non-gestational ovarian choriocarcinoma	11.4
5	extragonadal seminoma	10.3	SALL4 AFP
6	sarcomatous intrahepatic cholangiocarcinoma	10.3	GPC3 AFP
7	malignant pineal area germ cell neoplasm	10.3	SALL4 AFP
8	mixed hepatoblastoma	10.3	GPC3 AFP
9	dysgerminoma	10.3	KRT7 AFP
10	testicular malignant germ cell cancer	10.3	GPC3 AFP
11	gonadoblastoma	10.3	POU5F1 AFP
12	rectum neuroendocrine neoplasm	10.3	KRT7 AFP
13	epididymal neoplasm	10.3	KRT7 AFP
14	mucinous ovarian cystadenoma	10.3	KRT7 AFP
15	ovarian cystadenoma	10.3	KRT7 AFP
16	colonic lymphangioma	10.3	KRT7 AFP
17	childhood testicular germ cell tumor	10.3	POU5F1 AFP
18	bile duct cystadenocarcinoma	10.3	KRT7 AFP
19	middle ear adenocarcinoma	10.3	KRT7 AFP
20	liver leiomyosarcoma	10.2	GPC3 AFP
21	liver sarcoma	10.2	KRT7 AFP
22	sublingual gland adenoid cystic carcinoma	10.2	KRT7 GPC3
23	sublingual gland cancer	10.2	KRT7 GPC3
24	biliary tract benign neoplasm	10.2	KRT7 AFP
25	sclerosing hepatic carcinoma	10.2	GPC3 AFP
26	epithelioid trophoblastic tumor	10.2	SALL4 KRT7
27	anal fistula	10.2	KRT7 AFP
28	bile duct adenoma	10.2	KRT7 AFP
29	diencephalic astrocytoma	10.2	SALL4 POU5F1
30	intrahepatic bile duct adenoma	10.2	KRT7 AFP
31	bile duct cysts	10.2	KRT7 AFP
32	mediastinal cancer	10.2	KRT7 AFP
33	brain germinoma	10.2	POU5F1 AFP
34	liver benign neoplasm	10.2	GPC3 AFP
35	adenomatoid tumor	10.2	KRT7 AFP
36	klatskin's tumor	10.2	KRT7 AFP
37	mucinous cystadenocarcinoma	10.2	KRT7 AFP
38	cecal disease	10.2	KRT7 AFP
39	hydrocele	10.2	KRT7 AFP
40	testicular yolk sac tumor	10.2	SALL4 GPC3 AFP
41	benign mesothelioma	10.2	KRT7 GPC3
42	adult hepatocellular carcinoma	10.1	GPC3 AFP
43	acinar cell carcinoma	10.1	KRT7 AFP
44	choriocarcinoma of the testis	10.1	SALL4 KRT7 AFP
45	cholangiolocellular carcinoma	10.1	SALL4 KRT7 AFP
46	blastoma	10.1	SALL4 KRT7 AFP
47	ureter squamous cell carcinoma	10.1	NAPSA KRT7
48	cervical mucinous adenocarcinoma	10.1	NAPSA KRT7
49	cervical clear cell adenocarcinoma	10.1	NAPSA KRT7
50	sertoli-leydig cell tumor	10.1	KRT7 AFP

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:

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Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

²⁵ (show all 16)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-117	9.58	AFP
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.58	POU5F1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	9.58	POU5F1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.58	KRT7
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.58	POU5F1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-171	9.58	POU5F1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.58	AFP KRT7 POU5F1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-216	9.58	POU5F1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.58	POU5F1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-48	9.58	AFP
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	9.58	KRT7
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-72	9.58	KRT7
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.58	KRT7 POU5F1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-89	9.58	AFP
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.58	KRT7
16	Decreased Aire reporter expression	GR00304-A	9.13	NKX2-5 POU5F1 SALL4

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Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials, NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

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Genetic Tests for Ovarian Primitive Germ Cell Tumor

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Anatomical Context for Ovarian Primitive Germ Cell Tumor

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Publications for Ovarian Primitive Germ Cell Tumor

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Genes for Ovarian Primitive Germ Cell Tumor

Genes related to Ovarian Primitive Germ Cell Tumor (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AFP	Alpha Fetoprotein	Protein Coding	7.01	DISEASES inferred ¹⁴
2	SALL4	Spalt Like Transcription Factor 4	Protein Coding	6.42	DISEASES inferred ¹⁴
3	GPC3	Glypican 3	Protein Coding	6.33	DISEASES inferred ¹⁴
4	RTL3	Retrotransposon Gag Like 3	Protein Coding	5.86	DISEASES inferred ¹⁴
5	KRT7	Keratin 7	Protein Coding	5.41	DISEASES inferred ¹⁴
6	POU5F1	POU Class 5 Homeobox 1	Protein Coding	4.96	DISEASES inferred ¹⁴
7	NKX2-5	NK2 Homeobox 5	Protein Coding	4.71	DISEASES inferred ¹⁴
8	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	4.7	DISEASES inferred ¹⁴
9	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	4.7	DISEASES inferred ¹⁴
10	KIF17	Kinesin Family Member 17	Protein Coding	4.59	DISEASES inferred ¹⁴
11	PAX8	Paired Box 8	Protein Coding	4.56	DISEASES inferred ¹⁴
12	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	4.54	DISEASES inferred ¹⁴

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Variations for Ovarian Primitive Germ Cell Tumor

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Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

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Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ³	11.39	POU5F1 NKX2-5 AFP
2	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	10.92	POU5F1 NKX2-5 AFP
3	Transcriptional regulation of pluripotent stem cells ⁶⁶ Show member pathways "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation" ⁶⁶	10.72	SALL4 POU5F1

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GO Terms for Ovarian Primitive Germ Cell Tumor

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	epithelial cell differentiation	GO:0030855	9.02	PAX8 NKX2-5 GSTA1

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Sources for Ovarian Primitive Germ Cell Tumor

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

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¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: OVR056 MIFTS: 19	Ovarian Primitive Germ Cell Tumor Categories: Cancer diseases, Endocrine diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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