MCID: OVR056
MIFTS: 19

Ovarian Primitive Germ Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5351
NCIt 49 C39986
UMLS 71 C1518727

Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology: 11 A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary: Ovarian Primitive Germ Cell Tumor is related to ovarian mixed germ cell neoplasm and ovarian endodermal sinus tumor. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 ovarian mixed germ cell neoplasm 32.1 PAX8 AFP
2 ovarian endodermal sinus tumor 29.7 SALL4 POU5F1 PAX8 NKX2-5 NAPSA KRT7
3 polyembryoma of the ovary 11.4
4 non-gestational ovarian choriocarcinoma 11.4
5 extragonadal seminoma 10.3 SALL4 AFP
6 sarcomatous intrahepatic cholangiocarcinoma 10.3 GPC3 AFP
7 malignant pineal area germ cell neoplasm 10.3 SALL4 AFP
8 mixed hepatoblastoma 10.3 GPC3 AFP
9 dysgerminoma 10.3 KRT7 AFP
10 testicular malignant germ cell cancer 10.3 GPC3 AFP
11 gonadoblastoma 10.3 POU5F1 AFP
12 rectum neuroendocrine neoplasm 10.3 KRT7 AFP
13 epididymal neoplasm 10.3 KRT7 AFP
14 mucinous ovarian cystadenoma 10.3 KRT7 AFP
15 ovarian cystadenoma 10.3 KRT7 AFP
16 colonic lymphangioma 10.3 KRT7 AFP
17 childhood testicular germ cell tumor 10.3 POU5F1 AFP
18 bile duct cystadenocarcinoma 10.3 KRT7 AFP
19 middle ear adenocarcinoma 10.3 KRT7 AFP
20 liver leiomyosarcoma 10.2 GPC3 AFP
21 liver sarcoma 10.2 KRT7 AFP
22 sublingual gland adenoid cystic carcinoma 10.2 KRT7 GPC3
23 sublingual gland cancer 10.2 KRT7 GPC3
24 biliary tract benign neoplasm 10.2 KRT7 AFP
25 sclerosing hepatic carcinoma 10.2 GPC3 AFP
26 epithelioid trophoblastic tumor 10.2 SALL4 KRT7
27 anal fistula 10.2 KRT7 AFP
28 bile duct adenoma 10.2 KRT7 AFP
29 diencephalic astrocytoma 10.2 SALL4 POU5F1
30 intrahepatic bile duct adenoma 10.2 KRT7 AFP
31 bile duct cysts 10.2 KRT7 AFP
32 mediastinal cancer 10.2 KRT7 AFP
33 brain germinoma 10.2 POU5F1 AFP
34 liver benign neoplasm 10.2 GPC3 AFP
35 adenomatoid tumor 10.2 KRT7 AFP
36 klatskin's tumor 10.2 KRT7 AFP
37 mucinous cystadenocarcinoma 10.2 KRT7 AFP
38 cecal disease 10.2 KRT7 AFP
39 hydrocele 10.2 KRT7 AFP
40 testicular yolk sac tumor 10.2 SALL4 GPC3 AFP
41 benign mesothelioma 10.2 KRT7 GPC3
42 adult hepatocellular carcinoma 10.1 GPC3 AFP
43 acinar cell carcinoma 10.1 KRT7 AFP
44 choriocarcinoma of the testis 10.1 SALL4 KRT7 AFP
45 cholangiolocellular carcinoma 10.1 SALL4 KRT7 AFP
46 blastoma 10.1 SALL4 KRT7 AFP
47 ureter squamous cell carcinoma 10.1 NAPSA KRT7
48 cervical mucinous adenocarcinoma 10.1 NAPSA KRT7
49 cervical clear cell adenocarcinoma 10.1 NAPSA KRT7
50 sertoli-leydig cell tumor 10.1 KRT7 AFP

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:



Diseases related to Ovarian Primitive Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.58 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.58 POU5F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.58 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 KRT7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.58 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.58 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.58 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-216 9.58 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.58 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.58 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.58 KRT7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.58 KRT7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 KRT7 POU5F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.58 AFP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.58 KRT7
16 Decreased Aire reporter expression GR00304-A 9.13 NKX2-5 POU5F1 SALL4

Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials, NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

Genetic Tests for Ovarian Primitive Germ Cell Tumor

Anatomical Context for Ovarian Primitive Germ Cell Tumor

Publications for Ovarian Primitive Germ Cell Tumor

Variations for Ovarian Primitive Germ Cell Tumor

Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 POU5F1 NKX2-5 AFP
2 10.92 POU5F1 NKX2-5 AFP
3
Show member pathways
10.72 SALL4 POU5F1

GO Terms for Ovarian Primitive Germ Cell Tumor

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epithelial cell differentiation GO:0030855 9.02 PAX8 NKX2-5 GSTA1

Sources for Ovarian Primitive Germ Cell Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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