MCID: OVR056
MIFTS: 24

Ovarian Primitive Germ Cell Tumor

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5351
NCIt 50 C39986
UMLS 73 C1518727

Summaries for Ovarian Primitive Germ Cell Tumor

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to endodermal sinus tumor and mucinous cystadenofibroma. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 30.1 AFP KRT7 SALL4 SERPINA1
2 mucinous cystadenofibroma 10.8 AFP SERPINA1
3 polyembryoma 10.8 AFP SERPINA1
4 intrahepatic bile duct adenoma 10.8 AFP KRT7
5 malignant teratoma 10.7 AFP SALL4
6 renal pelvis adenocarcinoma 10.7 AFP KRT7
7 bile duct cystadenocarcinoma 10.7 AFP KRT7
8 intratubular embryonal carcinoma 10.7 AFP KRT7
9 testicular malignant germ cell cancer 10.7 AFP GPC3
10 ovarian embryonal carcinoma 10.6 AFP GPC3
11 epithelioid trophoblastic tumor 10.6 KRT7 SALL4
12 choriocarcinoma of the testis 10.6 AFP KRT7
13 adenomatoid tumor 10.6 AFP KRT7
14 pancreatoblastoma 10.6 AFP SERPINA1
15 hepatic adenomas, familial 10.6 AFP GPC3
16 sertoli-leydig cell tumor 10.6 AFP KRT7
17 malignant biphasic mesothelioma 10.6 AFP KRT7
18 placental site trophoblastic tumor 10.5 GPC3 SALL4
19 non-gestational ovarian choriocarcinoma 10.5 SRY TEK
20 pancreatic cystadenocarcinoma 10.5 AFP SERPINA1
21 extragonadal seminoma 10.5 AFP SALL4
22 choriocarcinoma of ovary 10.5 SRY TEK
23 acinar cell carcinoma 10.4 AFP KRT7 SERPINA1
24 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 GPC3 SERPINA1
25 seminal vesicle tumor 10.3 AFP GPC3 KRT7
26 bile duct adenocarcinoma 10.3 AFP GPC3 KRT7
27 gastrointestinal system cancer 10.3 AFP GPC3 KRT7
28 hepatoblastoma 10.3 AFP GPC3 KRT7
29 atypical choroid plexus papilloma 10.3 KRT7 SRY
30 inverted papilloma 10.3 KRT7 MSX2
31 adenosquamous pancreas carcinoma 10.2 KRT7 TEK
32 ovarian germ cell cancer 10.2 AFP HLX KRT7 SALL4
33 liver cirrhosis 10.2 AFP GPC3 SERPINA1
34 testicular yolk sac tumor 10.0 AFP GPC3 SALL4 SERPINA1
35 germ cells tumors 10.0
36 cystadenofibroma 10.0 AFP KRT7 SERPINA1 SRY
37 pancreatic mucinous cystadenoma 9.9 EZH2 KRT7
38 granulosa cell tumor of the ovary 9.8 KRT7 SERPINA1
39 cholangiocarcinoma 9.7 AFP EZH2 GPC3 KRT7
40 ovarian endodermal sinus tumor 5.0 AFP EZH2 GPC3 GSTA1 HLX HOXB7

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:



Diseases related to Ovarian Primitive Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.36 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.36 SRY
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.36 NKX2-5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.36 SRY
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.36 NKX2-5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.36 AFP NKX2-5 SRY
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 AFP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.36 AFP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 AFP

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
2 embryo MP:0005380 9.8 EZH2 GPC3 MSX2 NKX2-5 SALL4 SIRT1
3 endocrine/exocrine gland MP:0005379 9.76 AFP EZH2 HLX HOXB7 KPNA1 MSX2
4 hematopoietic system MP:0005397 9.61 SIRT1 TEK EZH2 GPC3 HLX HOXB7
5 homeostasis/metabolism MP:0005376 9.32 AFP EZH2 GPC3 HLX KPNA1 KRT7

Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

Genetic Tests for Ovarian Primitive Germ Cell Tumor

Anatomical Context for Ovarian Primitive Germ Cell Tumor

Publications for Ovarian Primitive Germ Cell Tumor

Articles related to Ovarian Primitive Germ Cell Tumor:

# Title Authors Year
1
SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. ( 19295406 )
2009

Variations for Ovarian Primitive Germ Cell Tumor

Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.97 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.83 EZH2 MSX2 NKX2-5 SALL4 SIRT1
3 viral process GO:0016032 9.78 KPNA1 KPNA2 KRT7 SIRT1
4 embryonic hindlimb morphogenesis GO:0035116 9.49 GPC3 MSX2
5 outflow tract septum morphogenesis GO:0003148 9.46 MSX2 NKX2-5
6 NLS-bearing protein import into nucleus GO:0006607 9.4 KPNA1 KPNA2
7 heart trabecula formation GO:0060347 9.32 NKX2-5 TEK
8 ovulation from ovarian follicle GO:0001542 9.26 AFP SIRT1
9 multicellular organism development GO:0007275 9.17 HLX HOXB7 MSX2 NKX2-5 SALL4 SIRT1
10 modulation by virus of host process GO:0019054 9.16 KPNA1 KPNA2
11 regulation of DNA recombination GO:0000018 8.96 KPNA1 KPNA2

Molecular functions related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.91 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2 sequence-specific DNA binding GO:0043565 9.63 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
3 transcription regulatory region DNA binding GO:0044212 9.56 EZH2 MSX2 NKX2-5 SALL4
4 protein binding GO:0005515 9.53 AFP EZH2 GPC3 GSTA1 HLX HOXB7
5 nuclear localization sequence binding GO:0008139 9.4 KPNA1 KPNA2
6 transcription factor binding GO:0008134 9.35 MSX2 NKX2-5 SALL4 SIRT1 SRY
7 nuclear import signal receptor activity GO:0061608 9.32 KPNA1 KPNA2

Sources for Ovarian Primitive Germ Cell Tumor

3 CDC
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11 DGIdb
17 ExPASy
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62 PubMed
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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