MCID: OVR056
MIFTS: 27

Ovarian Primitive Germ Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5351
NCIt 50 C39986
UMLS 73 C1518727

Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to non-gestational ovarian choriocarcinoma and endodermal sinus tumor. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. Affiliated tissues include skin, liver and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 non-gestational ovarian choriocarcinoma 32.3 SRY TEK
2 endodermal sinus tumor 30.2 AFP GPC3 SALL4 SERPINA1
3 ovarian endodermal sinus tumor 29.7 AFP EZH2 GPC3 GSTA1 HLX HOXB7
4 ovarian mixed germ cell neoplasm 11.4
5 polyembryoma of the ovary 11.4
6 mucinous cystadenofibroma 10.2 AFP SERPINA1
7 polyembryoma 10.2 AFP SERPINA1
8 intrahepatic bile duct adenoma 10.2 AFP KRT7
9 renal pelvis adenocarcinoma 10.2 AFP KRT7
10 malignant teratoma 10.2 AFP SALL4
11 intratubular embryonal carcinoma 10.2 AFP KRT7
12 bile duct cystadenocarcinoma 10.2 AFP KRT7
13 testicular malignant germ cell cancer 10.2 AFP GPC3
14 ovarian embryonal carcinoma 10.2 AFP GPC3
15 epithelioid trophoblastic tumor 10.2 KRT7 SALL4
16 choriocarcinoma of the testis 10.2 AFP KRT7
17 pancreatoblastoma 10.2 AFP SERPINA1
18 adenomatoid tumor 10.2 AFP KRT7
19 hepatic adenomas, familial 10.2 AFP GPC3
20 sertoli-leydig cell tumor 10.2 AFP KRT7
21 extragonadal seminoma 10.2 AFP SALL4
22 bile duct adenoma 10.1 EZH2 KRT7
23 choriocarcinoma of ovary 10.1 SRY TEK
24 acinar cell carcinoma 10.1 AFP KRT7 SERPINA1
25 embryoma 10.1 AFP GPC3 SALL4
26 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 GPC3 SERPINA1
27 seminal vesicle tumor 10.1 AFP GPC3 KRT7
28 bile duct adenocarcinoma 10.1 AFP GPC3 KRT7
29 mixed cell type cancer 10.1 AFP KRT7
30 hepatoblastoma 10.1 AFP GPC3 KRT7
31 dysgerminoma 10.1 AFP KRT7 SRY
32 gastrointestinal system cancer 10.1 AFP GPC3 KRT7
33 atypical choroid plexus papilloma 10.1 KRT7 SRY
34 ovarian germ cell cancer 10.1 AFP HLX KRT7 SALL4
35 pancreatic mucinous cystadenoma 10.0 EZH2 KRT7
36 granulosa cell tumor of the ovary 10.0 KRT7 SERPINA1
37 testicular yolk sac tumor 10.0 AFP GPC3 SALL4 SERPINA1
38 cystadenofibroma 10.0 AFP KRT7 SERPINA1 SRY
39 liver cirrhosis 9.8 AFP GPC3 SERPINA1

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:



Diseases related to Ovarian Primitive Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.36 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.36 SRY
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.36 NKX2-5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.36 SRY
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.36 NKX2-5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.36 AFP NKX2-5 SRY
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 AFP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.36 AFP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.36 AFP

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.87 EZH2 GPC3 MSX2 NKX2-5 SALL4 SIRT1
2 endocrine/exocrine gland MP:0005379 9.86 AFP EZH2 HLX HOXB7 KPNA1 MSX2
3 digestive/alimentary MP:0005381 9.85 GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
4 hematopoietic system MP:0005397 9.81 EZH2 GPC3 HLX HOXB7 KPNA1 MSX2
5 homeostasis/metabolism MP:0005376 9.65 AFP EZH2 GPC3 HLX KPNA1 KRT7
6 mortality/aging MP:0010768 9.32 AFP EZH2 GPC3 HLX KPNA1 MSX2

Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

Genetic Tests for Ovarian Primitive Germ Cell Tumor

Anatomical Context for Ovarian Primitive Germ Cell Tumor

MalaCards organs/tissues related to Ovarian Primitive Germ Cell Tumor:

41
Skin, Liver, Ovary, Testis

Publications for Ovarian Primitive Germ Cell Tumor

Variations for Ovarian Primitive Germ Cell Tumor

Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP NKX2-5 SERPINA1
2 9.8 KPNA1 KPNA2

GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ESC/E(Z) complex GO:0035098 8.62 EZH2 SIRT1

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.91 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2 viral process GO:0016032 9.76 KPNA1 KPNA2 KRT7 SIRT1
3 positive regulation of BMP signaling pathway GO:0030513 9.51 GPC3 MSX2
4 embryonic hindlimb morphogenesis GO:0035116 9.49 GPC3 MSX2
5 outflow tract septum morphogenesis GO:0003148 9.48 MSX2 NKX2-5
6 NLS-bearing protein import into nucleus GO:0006607 9.43 KPNA1 KPNA2
7 heart trabecula formation GO:0060347 9.4 NKX2-5 TEK
8 postsynapse to nucleus signaling pathway GO:0099527 9.32 KPNA1 KPNA2
9 ovulation from ovarian follicle GO:0001542 9.26 AFP SIRT1
10 modulation by virus of host process GO:0019054 9.16 KPNA1 KPNA2
11 negative regulation of transcription by RNA polymerase II GO:0000122 9.1 EZH2 MSX2 NKX2-5 SALL4 SIRT1 SRY
12 regulation of DNA recombination GO:0000018 8.96 KPNA1 KPNA2

Molecular functions related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.8 EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2 sequence-specific DNA binding GO:0043565 9.77 EZH2 HLX HOXB7 MSX2 NKX2-5
3 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.62 HOXB7 NKX2-5 SIRT1 SRY
4 nuclear localization sequence binding GO:0008139 9.43 KPNA1 KPNA2
5 nuclear import signal receptor activity GO:0061608 9.16 KPNA1 KPNA2
6 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.13 HOXB7 NKX2-5 SRY
7 transcription factor binding GO:0008134 9.02 MSX2 NKX2-5 SALL4 SIRT1 SRY
8 protein binding GO:0005515 10.25 AFP EZH2 GPC3 HLX HOXB7 KPNA1

Sources for Ovarian Primitive Germ Cell Tumor

3 CDC
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11 DGIdb
17 ExPASy
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28 GO
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32 HPO
33 ICD10
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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