Ovarian Primitive Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5351

NCIt ⁵⁰ C39986

UMLS ⁷³ C1518727

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Summaries for Ovarian Primitive Germ Cell Tumor

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to endodermal sinus tumor and mucinous cystadenofibroma. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)

#	Related Disease	Score	Top Affiliating Genes
1	endodermal sinus tumor	30.1	AFP KRT7 SALL4 SERPINA1
2	mucinous cystadenofibroma	10.8	AFP SERPINA1
3	polyembryoma	10.8	AFP SERPINA1
4	intrahepatic bile duct adenoma	10.8	AFP KRT7
5	malignant teratoma	10.7	AFP SALL4
6	renal pelvis adenocarcinoma	10.7	AFP KRT7
7	bile duct cystadenocarcinoma	10.7	AFP KRT7
8	intratubular embryonal carcinoma	10.7	AFP KRT7
9	testicular malignant germ cell cancer	10.7	AFP GPC3
10	ovarian embryonal carcinoma	10.6	AFP GPC3
11	epithelioid trophoblastic tumor	10.6	KRT7 SALL4
12	choriocarcinoma of the testis	10.6	AFP KRT7
13	adenomatoid tumor	10.6	AFP KRT7
14	pancreatoblastoma	10.6	AFP SERPINA1
15	hepatic adenomas, familial	10.6	AFP GPC3
16	sertoli-leydig cell tumor	10.6	AFP KRT7
17	malignant biphasic mesothelioma	10.6	AFP KRT7
18	placental site trophoblastic tumor	10.5	GPC3 SALL4
19	non-gestational ovarian choriocarcinoma	10.5	SRY TEK
20	pancreatic cystadenocarcinoma	10.5	AFP SERPINA1
21	extragonadal seminoma	10.5	AFP SALL4
22	choriocarcinoma of ovary	10.5	SRY TEK
23	acinar cell carcinoma	10.4	AFP KRT7 SERPINA1
24	polyposis, skin pigmentation, alopecia, and fingernail changes	10.4	GPC3 SERPINA1
25	seminal vesicle tumor	10.3	AFP GPC3 KRT7
26	bile duct adenocarcinoma	10.3	AFP GPC3 KRT7
27	gastrointestinal system cancer	10.3	AFP GPC3 KRT7
28	hepatoblastoma	10.3	AFP GPC3 KRT7
29	atypical choroid plexus papilloma	10.3	KRT7 SRY
30	inverted papilloma	10.3	KRT7 MSX2
31	adenosquamous pancreas carcinoma	10.2	KRT7 TEK
32	ovarian germ cell cancer	10.2	AFP HLX KRT7 SALL4
33	liver cirrhosis	10.2	AFP GPC3 SERPINA1
34	testicular yolk sac tumor	10.0	AFP GPC3 SALL4 SERPINA1
35	germ cells tumors	10.0
36	cystadenofibroma	10.0	AFP KRT7 SERPINA1 SRY
37	pancreatic mucinous cystadenoma	9.9	EZH2 KRT7
38	granulosa cell tumor of the ovary	9.8	KRT7 SERPINA1
39	cholangiocarcinoma	9.7	AFP EZH2 GPC3 KRT7
40	ovarian endodermal sinus tumor	5.0	AFP EZH2 GPC3 GSTA1 HLX HOXB7

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:

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Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	9.36	AFP
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-150	9.36	SRY
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-160	9.36	NKX2-5
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-17	9.36	SRY
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-204	9.36	NKX2-5
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-48	9.36	AFP NKX2-5 SRY
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-65	9.36	AFP
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-75	9.36	AFP
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-89	9.36	AFP

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.8	GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
2	embryo	MP:0005380	9.8	EZH2 GPC3 MSX2 NKX2-5 SALL4 SIRT1
3	endocrine/exocrine gland	MP:0005379	9.76	AFP EZH2 HLX HOXB7 KPNA1 MSX2
4	hematopoietic system	MP:0005397	9.61	SIRT1 TEK EZH2 GPC3 HLX HOXB7
5	homeostasis/metabolism	MP:0005376	9.32	AFP EZH2 GPC3 HLX KPNA1 KRT7

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Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

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Genetic Tests for Ovarian Primitive Germ Cell Tumor

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Anatomical Context for Ovarian Primitive Germ Cell Tumor

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Publications for Ovarian Primitive Germ Cell Tumor

Articles related to Ovarian Primitive Germ Cell Tumor:

#	Title	Authors	Year
1	SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. ( 19295406 )	Cao D....Peng Y.	2009

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Genes for Ovarian Primitive Germ Cell Tumor

Genes related to Ovarian Primitive Germ Cell Tumor (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AFP	Alpha Fetoprotein	Protein Coding	16.52	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	HLX	H2.0 Like Homeobox	Protein Coding	15.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	14.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	MSX2	Msh Homeobox 2	Protein Coding	14.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SALL4	Spalt Like Transcription Factor 4	Protein Coding	14.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	NKX2-5	NK2 Homeobox 5	Protein Coding	14.39	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	SERPINA1	Serpin Family A Member 1	Protein Coding	14.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	KRT7	Keratin 7	Protein Coding	14.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	13.94	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	GPC3	Glypican 3	Protein Coding	13.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	SRY	Sex Determining Region Y	Protein Coding	13.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	13.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	SIRT1	Sirtuin 1	Protein Coding	13.21	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	5.36	DISEASES inferred ¹⁵
15	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	5.3	DISEASES inferred ¹⁵
16	HOXB7	Homeobox B7	Protein Coding	5.18	DISEASES inferred ¹⁵

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Variations for Ovarian Primitive Germ Cell Tumor

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Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

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Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.26	AFP NKX2-5 SERPINA1
2	Ran Pathway ⁶⁴	9.8	KPNA1 KPNA2

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GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ESC/E(Z) complex	GO:0035098	8.62	EZH2 SIRT1

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.97	EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2	negative regulation of transcription by RNA polymerase II	GO:0000122	9.83	EZH2 MSX2 NKX2-5 SALL4 SIRT1
3	viral process	GO:0016032	9.78	KPNA1 KPNA2 KRT7 SIRT1
4	embryonic hindlimb morphogenesis	GO:0035116	9.49	GPC3 MSX2
5	outflow tract septum morphogenesis	GO:0003148	9.46	MSX2 NKX2-5
6	NLS-bearing protein import into nucleus	GO:0006607	9.4	KPNA1 KPNA2
7	heart trabecula formation	GO:0060347	9.32	NKX2-5 TEK
8	ovulation from ovarian follicle	GO:0001542	9.26	AFP SIRT1
9	multicellular organism development	GO:0007275	9.17	HLX HOXB7 MSX2 NKX2-5 SALL4 SIRT1
10	modulation by virus of host process	GO:0019054	9.16	KPNA1 KPNA2
11	regulation of DNA recombination	GO:0000018	8.96	KPNA1 KPNA2

Molecular functions related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	9.91	EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2	sequence-specific DNA binding	GO:0043565	9.63	EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
3	transcription regulatory region DNA binding	GO:0044212	9.56	EZH2 MSX2 NKX2-5 SALL4
4	protein binding	GO:0005515	9.53	AFP EZH2 GPC3 GSTA1 HLX HOXB7
5	nuclear localization sequence binding	GO:0008139	9.4	KPNA1 KPNA2
6	transcription factor binding	GO:0008134	9.35	MSX2 NKX2-5 SALL4 SIRT1 SRY
7	nuclear import signal receptor activity	GO:0061608	9.32	KPNA1 KPNA2

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