Ovarian Primitive Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5351

NCIt ⁵⁰ C39986

UMLS ⁷³ C1518727

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Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology : ¹² A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to non-gestational ovarian choriocarcinoma and endodermal sinus tumor. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Ran Pathway. Affiliated tissues include skin, liver and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

#	Related Disease	Score	Top Affiliating Genes
1	non-gestational ovarian choriocarcinoma	32.3	SRY TEK
2	endodermal sinus tumor	30.2	AFP GPC3 SALL4 SERPINA1
3	ovarian endodermal sinus tumor	29.7	AFP EZH2 GPC3 GSTA1 HLX HOXB7
4	ovarian mixed germ cell neoplasm	11.4
5	polyembryoma of the ovary	11.4
6	mucinous cystadenofibroma	10.2	AFP SERPINA1
7	polyembryoma	10.2	AFP SERPINA1
8	intrahepatic bile duct adenoma	10.2	AFP KRT7
9	renal pelvis adenocarcinoma	10.2	AFP KRT7
10	malignant teratoma	10.2	AFP SALL4
11	intratubular embryonal carcinoma	10.2	AFP KRT7
12	bile duct cystadenocarcinoma	10.2	AFP KRT7
13	testicular malignant germ cell cancer	10.2	AFP GPC3
14	ovarian embryonal carcinoma	10.2	AFP GPC3
15	epithelioid trophoblastic tumor	10.2	KRT7 SALL4
16	choriocarcinoma of the testis	10.2	AFP KRT7
17	pancreatoblastoma	10.2	AFP SERPINA1
18	adenomatoid tumor	10.2	AFP KRT7
19	hepatic adenomas, familial	10.2	AFP GPC3
20	sertoli-leydig cell tumor	10.2	AFP KRT7
21	extragonadal seminoma	10.2	AFP SALL4
22	bile duct adenoma	10.1	EZH2 KRT7
23	choriocarcinoma of ovary	10.1	SRY TEK
24	acinar cell carcinoma	10.1	AFP KRT7 SERPINA1
25	embryoma	10.1	AFP GPC3 SALL4
26	polyposis, skin pigmentation, alopecia, and fingernail changes	10.1	GPC3 SERPINA1
27	seminal vesicle tumor	10.1	AFP GPC3 KRT7
28	bile duct adenocarcinoma	10.1	AFP GPC3 KRT7
29	mixed cell type cancer	10.1	AFP KRT7
30	hepatoblastoma	10.1	AFP GPC3 KRT7
31	dysgerminoma	10.1	AFP KRT7 SRY
32	gastrointestinal system cancer	10.1	AFP GPC3 KRT7
33	atypical choroid plexus papilloma	10.1	KRT7 SRY
34	ovarian germ cell cancer	10.1	AFP HLX KRT7 SALL4
35	pancreatic mucinous cystadenoma	10.0	EZH2 KRT7
36	granulosa cell tumor of the ovary	10.0	KRT7 SERPINA1
37	testicular yolk sac tumor	10.0	AFP GPC3 SALL4 SERPINA1
38	cystadenofibroma	10.0	AFP KRT7 SERPINA1 SRY
39	liver cirrhosis	9.8	AFP GPC3 SERPINA1

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:

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Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	9.36	AFP
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-150	9.36	SRY
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-160	9.36	NKX2-5
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-17	9.36	SRY
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-204	9.36	NKX2-5
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-48	9.36	AFP NKX2-5 SRY
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-65	9.36	AFP
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-75	9.36	AFP
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-89	9.36	AFP

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryo	MP:0005380	9.87	EZH2 GPC3 MSX2 NKX2-5 SALL4 SIRT1
2	endocrine/exocrine gland	MP:0005379	9.86	AFP EZH2 HLX HOXB7 KPNA1 MSX2
3	digestive/alimentary	MP:0005381	9.85	GPC3 HLX MSX2 NKX2-5 SALL4 SIRT1
4	hematopoietic system	MP:0005397	9.81	EZH2 GPC3 HLX HOXB7 KPNA1 MSX2
5	homeostasis/metabolism	MP:0005376	9.65	AFP EZH2 GPC3 HLX KPNA1 KRT7
6	mortality/aging	MP:0010768	9.32	AFP EZH2 GPC3 HLX KPNA1 MSX2

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Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

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Genetic Tests for Ovarian Primitive Germ Cell Tumor

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Anatomical Context for Ovarian Primitive Germ Cell Tumor

MalaCards organs/tissues related to Ovarian Primitive Germ Cell Tumor:

⁴¹

Skin, Liver, Ovary, Testis

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Publications for Ovarian Primitive Germ Cell Tumor

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Genes for Ovarian Primitive Germ Cell Tumor

Genes related to Ovarian Primitive Germ Cell Tumor (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AFP	Alpha Fetoprotein	Protein Coding	16.31	DISEASES inferred ¹⁵
2	HLX	H2.0 Like Homeobox	Protein Coding	15.59	DISEASES inferred ¹⁵
3	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	14.67	DISEASES inferred ¹⁵
4	MSX2	Msh Homeobox 2	Protein Coding	14.66	DISEASES inferred ¹⁵
5	SALL4	Spalt Like Transcription Factor 4	Protein Coding	14.36	DISEASES inferred ¹⁵
6	NKX2-5	NK2 Homeobox 5	Protein Coding	14.35	DISEASES inferred ¹⁵
7	SERPINA1	Serpin Family A Member 1	Protein Coding	14.15	DISEASES inferred ¹⁵
8	KRT7	Keratin 7	Protein Coding	14.05	DISEASES inferred ¹⁵
9	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	13.83	DISEASES inferred ¹⁵
10	GPC3	Glypican 3	Protein Coding	13.65	DISEASES inferred ¹⁵
11	SRY	Sex Determining Region Y	Protein Coding	13.6	DISEASES inferred ¹⁵
12	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	13.36	DISEASES inferred ¹⁵
13	SIRT1	Sirtuin 1	Protein Coding	13.11	DISEASES inferred ¹⁵
14	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	5.21	DISEASES inferred ¹⁵
15	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	5.11	DISEASES inferred ¹⁵
16	HOXB7	Homeobox B7	Protein Coding	5	DISEASES inferred ¹⁵

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Variations for Ovarian Primitive Germ Cell Tumor

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Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

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Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.26	AFP NKX2-5 SERPINA1
2	Ran Pathway ⁶⁴	9.8	KPNA1 KPNA2

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GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ESC/E(Z) complex	GO:0035098	8.62	EZH2 SIRT1

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.91	EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2	viral process	GO:0016032	9.76	KPNA1 KPNA2 KRT7 SIRT1
3	positive regulation of BMP signaling pathway	GO:0030513	9.51	GPC3 MSX2
4	embryonic hindlimb morphogenesis	GO:0035116	9.49	GPC3 MSX2
5	outflow tract septum morphogenesis	GO:0003148	9.48	MSX2 NKX2-5
6	NLS-bearing protein import into nucleus	GO:0006607	9.43	KPNA1 KPNA2
7	heart trabecula formation	GO:0060347	9.4	NKX2-5 TEK
8	postsynapse to nucleus signaling pathway	GO:0099527	9.32	KPNA1 KPNA2
9	ovulation from ovarian follicle	GO:0001542	9.26	AFP SIRT1
10	modulation by virus of host process	GO:0019054	9.16	KPNA1 KPNA2
11	negative regulation of transcription by RNA polymerase II	GO:0000122	9.1	EZH2 MSX2 NKX2-5 SALL4 SIRT1 SRY
12	regulation of DNA recombination	GO:0000018	8.96	KPNA1 KPNA2

Molecular functions related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.8	EZH2 HLX HOXB7 MSX2 NKX2-5 SALL4
2	sequence-specific DNA binding	GO:0043565	9.77	EZH2 HLX HOXB7 MSX2 NKX2-5
3	proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001077	9.62	HOXB7 NKX2-5 SIRT1 SRY
4	nuclear localization sequence binding	GO:0008139	9.43	KPNA1 KPNA2
5	nuclear import signal receptor activity	GO:0061608	9.16	KPNA1 KPNA2
6	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0003705	9.13	HOXB7 NKX2-5 SRY
7	transcription factor binding	GO:0008134	9.02	MSX2 NKX2-5 SALL4 SIRT1 SRY
8	protein binding	GO:0005515	10.25	AFP EZH2 GPC3 HLX HOXB7 KPNA1

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