MCID: OVR056
MIFTS: 22

Ovarian Primitive Germ Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5351
NCIt 49 C39986
UMLS 71 C1518727

Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to testicular yolk sac tumor and endodermal sinus tumor. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cardiac Progenitor Differentiation. Affiliated tissues include testis, liver and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 testicular yolk sac tumor 30.5 GPC3 AFP
2 endodermal sinus tumor 29.5 SALL4 POU5F1 GPC3 AFP
3 teratoma 29.5 POU5F1 KRT7 GPC3 AFP
4 ovarian endodermal sinus tumor 28.6 SNORD126 SALL4 POU5F1 NKX2-5 KRT7 KAT7
5 ovarian mixed germ cell neoplasm 11.6
6 polyembryoma of the ovary 11.6
7 non-gestational ovarian choriocarcinoma 11.6
8 extragonadal seminoma 10.3 SALL4 AFP
9 extragonadal nonseminomatous germ cell tumor 10.3 SALL4 AFP
10 choriocarcinoma of the testis 10.3 SALL4 AFP
11 mixed germ cell cancer 10.3 SALL4 AFP
12 intrahepatic bile duct adenoma 10.3 KRT7 AFP
13 rete testis neoplasm 10.3 KRT7 AFP
14 sclerosing hepatic carcinoma 10.3 GPC3 AFP
15 rete testis adenocarcinoma 10.3 KRT7 AFP
16 renal pelvis adenocarcinoma 10.3 KRT7 AFP
17 spermatocytoma 10.3 SALL4 AFP
18 bile duct cystadenocarcinoma 10.3 KRT7 AFP
19 colonic lymphangioma 10.3 KRT7 AFP
20 epididymal neoplasm 10.3 KRT7 AFP
21 ovarian germ cell teratoma 10.3 KRT7 AFP
22 middle ear adenocarcinoma 10.3 KRT7 AFP
23 liver sarcoma 10.3 KRT7 AFP
24 benign mesothelioma 10.3 KRT7 AFP
25 hepatoid adenocarcinoma 10.3 GPC3 AFP
26 cystadenofibroma 10.3 KRT7 AFP
27 benign mesenchymoma 10.2 KRT7 AFP
28 epididymis adenocarcinoma 10.2 KRT7 AFP
29 simpson-golabi-behmel syndrome, type 1 10.2 GPC3 AFP
30 epididymis cancer 10.2 KRT7 AFP
31 epithelioid trophoblastic tumor 10.2 SALL4 KRT7
32 mediastinal cancer 10.2 KRT7 AFP
33 ovarian benign neoplasm 10.2 KRT7 AFP
34 liver benign neoplasm 10.2 GPC3 AFP
35 adenomatoid tumor 10.2 KRT7 AFP
36 placental site trophoblastic tumor 10.2 SALL4 GPC3
37 klatskin's tumor 10.2 KRT7 AFP
38 horner's syndrome 10.2 KRT7 GPC3
39 sertoli-leydig cell tumor 10.2 KRT7 AFP
40 acinar cell carcinoma 10.2 KRT7 AFP
41 sex cord-gonadal stromal tumor 10.2 KRT7 AFP
42 sertoli cell tumor 10.1 KRT7 AFP
43 cystic teratoma 10.1 KRT7 AFP
44 germinoma 10.1 POU5F1 AFP
45 tubular adenocarcinoma 10.1 KRT7 AFP
46 central nervous system germ cell tumor 10.1 POU5F1 AFP
47 hepatocellular adenoma 10.1 GPC3 AFP
48 struma ovarii 10.1
49 brain germinoma 10.1 POU5F1 AFP
50 epithelioid sarcoma 10.1 SALL4 KRT7

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:



Diseases related to Ovarian Primitive Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 KRT7 POU5F1
12 Decreased Aire reporter expression GR00304-A 9.13 NKX2-5 POU5F1 SALL4

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 GPC3 HLX NKX2-5 POU5F1 SALL4

Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

Genetic Tests for Ovarian Primitive Germ Cell Tumor

Anatomical Context for Ovarian Primitive Germ Cell Tumor

MalaCards organs/tissues related to Ovarian Primitive Germ Cell Tumor:

40
Testis, Liver, Brain, Colon, Ovary

Publications for Ovarian Primitive Germ Cell Tumor

Variations for Ovarian Primitive Germ Cell Tumor

Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

Pathways for Ovarian Primitive Germ Cell Tumor

GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 POU5F1 NKX2-5 KAT7 HLX

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.02 SALL4 POU5F1 NKX2-5 KAT7 HLX
2 somatic stem cell population maintenance GO:0035019 8.96 SALL4 POU5F1

Sources for Ovarian Primitive Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
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48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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