Ovarian Primitive Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5351

NCIt ⁴⁹ C39986

UMLS ⁷¹ C1518727

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Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology : ¹² A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to testicular yolk sac tumor and endodermal sinus tumor. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Cardiac Progenitor Differentiation. Affiliated tissues include testis, liver and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)

#	Related Disease	Score	Top Affiliating Genes
1	testicular yolk sac tumor	30.5	GPC3 AFP
2	endodermal sinus tumor	29.5	SALL4 POU5F1 GPC3 AFP
3	teratoma	29.5	POU5F1 KRT7 GPC3 AFP
4	ovarian endodermal sinus tumor	28.6	SNORD126 SALL4 POU5F1 NKX2-5 KRT7 KAT7
5	ovarian mixed germ cell neoplasm	11.6
6	polyembryoma of the ovary	11.6
7	non-gestational ovarian choriocarcinoma	11.6
8	extragonadal seminoma	10.3	SALL4 AFP
9	extragonadal nonseminomatous germ cell tumor	10.3	SALL4 AFP
10	choriocarcinoma of the testis	10.3	SALL4 AFP
11	mixed germ cell cancer	10.3	SALL4 AFP
12	intrahepatic bile duct adenoma	10.3	KRT7 AFP
13	rete testis neoplasm	10.3	KRT7 AFP
14	sclerosing hepatic carcinoma	10.3	GPC3 AFP
15	rete testis adenocarcinoma	10.3	KRT7 AFP
16	renal pelvis adenocarcinoma	10.3	KRT7 AFP
17	spermatocytoma	10.3	SALL4 AFP
18	bile duct cystadenocarcinoma	10.3	KRT7 AFP
19	colonic lymphangioma	10.3	KRT7 AFP
20	epididymal neoplasm	10.3	KRT7 AFP
21	ovarian germ cell teratoma	10.3	KRT7 AFP
22	middle ear adenocarcinoma	10.3	KRT7 AFP
23	liver sarcoma	10.3	KRT7 AFP
24	benign mesothelioma	10.3	KRT7 AFP
25	hepatoid adenocarcinoma	10.3	GPC3 AFP
26	cystadenofibroma	10.3	KRT7 AFP
27	benign mesenchymoma	10.2	KRT7 AFP
28	epididymis adenocarcinoma	10.2	KRT7 AFP
29	simpson-golabi-behmel syndrome, type 1	10.2	GPC3 AFP
30	epididymis cancer	10.2	KRT7 AFP
31	epithelioid trophoblastic tumor	10.2	SALL4 KRT7
32	mediastinal cancer	10.2	KRT7 AFP
33	ovarian benign neoplasm	10.2	KRT7 AFP
34	liver benign neoplasm	10.2	GPC3 AFP
35	adenomatoid tumor	10.2	KRT7 AFP
36	placental site trophoblastic tumor	10.2	SALL4 GPC3
37	klatskin's tumor	10.2	KRT7 AFP
38	horner's syndrome	10.2	KRT7 GPC3
39	sertoli-leydig cell tumor	10.2	KRT7 AFP
40	acinar cell carcinoma	10.2	KRT7 AFP
41	sex cord-gonadal stromal tumor	10.2	KRT7 AFP
42	sertoli cell tumor	10.1	KRT7 AFP
43	cystic teratoma	10.1	KRT7 AFP
44	germinoma	10.1	POU5F1 AFP
45	tubular adenocarcinoma	10.1	KRT7 AFP
46	central nervous system germ cell tumor	10.1	POU5F1 AFP
47	hepatocellular adenoma	10.1	GPC3 AFP
48	struma ovarii	10.1
49	brain germinoma	10.1	POU5F1 AFP
50	epithelioid sarcoma	10.1	SALL4 KRT7

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:

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Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	9.47	AFP
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.47	AFP
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.47	POU5F1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	9.47	POU5F1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.47	KRT7
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.47	POU5F1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.47	AFP KRT7 POU5F1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.47	AFP
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.47	POU5F1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.47	AFP
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.47	KRT7 POU5F1
12	Decreased Aire reporter expression	GR00304-A	9.13	NKX2-5 POU5F1 SALL4

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.02	GPC3 HLX NKX2-5 POU5F1 SALL4

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Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

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Genetic Tests for Ovarian Primitive Germ Cell Tumor

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Anatomical Context for Ovarian Primitive Germ Cell Tumor

MalaCards organs/tissues related to Ovarian Primitive Germ Cell Tumor:

⁴⁰

Testis, Liver, Brain, Colon, Ovary

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Publications for Ovarian Primitive Germ Cell Tumor

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Genes for Ovarian Primitive Germ Cell Tumor

Genes related to Ovarian Primitive Germ Cell Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AFP	Alpha Fetoprotein	Protein Coding	7.28	DISEASES inferred ¹⁵
2	SALL4	Spalt Like Transcription Factor 4	Protein Coding	6.82	DISEASES inferred ¹⁵
3	GPC3	Glypican 3	Protein Coding	6.6	DISEASES inferred ¹⁵
4	KRT7	Keratin 7	Protein Coding	5.72	DISEASES inferred ¹⁵
5	HLX	H2.0 Like Homeobox	Protein Coding	5.3	DISEASES inferred ¹⁵
6	KAT7	Lysine Acetyltransferase 7	Protein Coding	5.21	DISEASES inferred ¹⁵
7	POU5F1	POU Class 5 Homeobox 1	Protein Coding	5.21	DISEASES inferred ¹⁵
8	SNORD126	Small Nucleolar RNA, C/D Box 126	RNA Gene	5.03	DISEASES inferred ¹⁵
9	NKX2-5	NK2 Homeobox 5	Protein Coding	5.01	DISEASES inferred ¹⁵

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Variations for Ovarian Primitive Germ Cell Tumor

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Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

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Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ⁴	11.39	POU5F1 NKX2-5 AFP
2	Cardiac Progenitor Differentiation ¹	10.98	POU5F1 NKX2-5
3	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.92	POU5F1 NKX2-5 AFP
4	Transcriptional regulation of pluripotent stem cells ⁶⁵ Show member pathways POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation ⁶⁵	10.85	SALL4 POU5F1

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GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear chromatin	GO:0000790	8.92	POU5F1 NKX2-5 KAT7 HLX

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.02	SALL4 POU5F1 NKX2-5 KAT7 HLX
2	somatic stem cell population maintenance	GO:0035019	8.96	SALL4 POU5F1

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Sources for Ovarian Primitive Germ Cell Tumor

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