MCID: OVR056
MIFTS: 22

Ovarian Primitive Germ Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Ovarian Primitive Germ Cell Tumor

MalaCards integrated aliases for Ovarian Primitive Germ Cell Tumor:

Name: Ovarian Primitive Germ Cell Tumor 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5351
NCIt 49 C39986
UMLS 71 C1518727

Summaries for Ovarian Primitive Germ Cell Tumor

Disease Ontology : 12 A malignant ovarian germ cell neoplasm that has material basis in primitive germ cells.

MalaCards based summary : Ovarian Primitive Germ Cell Tumor is related to endodermal sinus tumor and teratoma. An important gene associated with Ovarian Primitive Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Ovarian Primitive Germ Cell Tumor

Diseases related to Ovarian Primitive Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 29.5 SALL4 POU5F1 KRT7 GPC3 AFP
2 teratoma 29.3 POU5F1 KRT7 GPC3 CDX2 AFP
3 ovarian endodermal sinus tumor 29.0 SALL4 POU5F1 NKX2-5 NAPSA KRT7 KAT7
4 ovarian mixed germ cell neoplasm 11.6
5 polyembryoma of the ovary 11.6
6 non-gestational ovarian choriocarcinoma 11.6
7 extragonadal seminoma 10.4 SALL4 AFP
8 choriocarcinoma of the testis 10.4 SALL4 AFP
9 childhood endodermal sinus tumor 10.4 SALL4 AFP
10 mixed germ cell cancer 10.4 SALL4 AFP
11 intrahepatic bile duct adenoma 10.4 KRT7 AFP
12 rete testis neoplasm 10.4 KRT7 AFP
13 germinoma 10.4 POU5F1 AFP
14 rete testis adenocarcinoma 10.4 KRT7 AFP
15 sclerosing hepatic carcinoma 10.4 GPC3 AFP
16 renal pelvis adenocarcinoma 10.4 KRT7 AFP
17 epididymal neoplasm 10.3 KRT7 AFP
18 bile duct cystadenocarcinoma 10.3 KRT7 AFP
19 spermatocytoma 10.3 SALL4 AFP
20 colonic lymphangioma 10.3 KRT7 AFP
21 pediatric testicular germ cell tumor 10.3 POU5F1 AFP
22 middle ear adenocarcinoma 10.3 KRT7 AFP
23 liver sarcoma 10.3 KRT7 AFP
24 benign mesothelioma 10.3 KRT7 AFP
25 biliary tract benign neoplasm 10.3 KRT7 AFP
26 ovarian germ cell teratoma 10.3 KRT7 AFP
27 cystadenofibroma 10.3 KRT7 AFP
28 middle ear carcinoma 10.3 KRT7 AFP
29 bile duct cysts 10.3 KRT7 AFP
30 dysgerminoma of ovary 10.3 POU5F1 AFP
31 epithelioid trophoblastic tumor 10.3 SALL4 KRT7
32 cervical clear cell adenocarcinoma 10.3 NAPSA AFP
33 mediastinal cancer 10.3 KRT7 AFP
34 brain germinoma 10.3 POU5F1 AFP
35 liver benign neoplasm 10.3 GPC3 AFP
36 ovarian benign neoplasm 10.3 KRT7 AFP
37 adenomatoid tumor 10.3 KRT7 AFP
38 klatskin's tumor 10.3 KRT7 AFP
39 clear cell adenocarcinoma 10.3 NAPSA KRT7
40 placental site trophoblastic tumor 10.3 SALL4 GPC3
41 adenofibroma 10.2 NAPSA KRT7
42 horner's syndrome 10.2 KRT7 GPC3
43 ovary neuroendocrine neoplasm 10.2 KRT7 CDX2
44 anal canal paget's disease 10.2 KRT7 CDX2
45 anal paget's disease 10.2 KRT7 CDX2
46 solid adenocarcinoma with mucin production 10.2 NAPSA KRT7
47 anal gland adenocarcinoma 10.2 KRT7 CDX2
48 sertoli-leydig cell tumor 10.2 KRT7 AFP
49 ureter adenocarcinoma 10.2 KRT7 CDX2
50 gastric signet ring cell adenocarcinoma 10.2 KRT7 CDX2

Graphical network of the top 20 diseases related to Ovarian Primitive Germ Cell Tumor:



Diseases related to Ovarian Primitive Germ Cell Tumor

Symptoms & Phenotypes for Ovarian Primitive Germ Cell Tumor

GenomeRNAi Phenotypes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.17 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.17 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.17 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.17 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.17 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.17 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 AFP
8 Decreased Aire reporter expression GR00304-A 9.13 NKX2-5 POU5F1 SALL4

MGI Mouse Phenotypes related to Ovarian Primitive Germ Cell Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CDX2 GPC3 KAT7 KRT7 NKX2-5 POU5F1
2 digestive/alimentary MP:0005381 9.63 CDX2 GPC3 HLX NKX2-5 POU5F1 SALL4
3 embryo MP:0005380 9.43 CDX2 GPC3 KAT7 NKX2-5 POU5F1 SALL4
4 mortality/aging MP:0010768 9.23 AFP CDX2 GPC3 HLX KAT7 NKX2-5

Drugs & Therapeutics for Ovarian Primitive Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Ovarian Primitive Germ Cell Tumor

Genetic Tests for Ovarian Primitive Germ Cell Tumor

Anatomical Context for Ovarian Primitive Germ Cell Tumor

Publications for Ovarian Primitive Germ Cell Tumor

Variations for Ovarian Primitive Germ Cell Tumor

Expression for Ovarian Primitive Germ Cell Tumor

Search GEO for disease gene expression data for Ovarian Primitive Germ Cell Tumor.

Pathways for Ovarian Primitive Germ Cell Tumor

Pathways related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.52 POU5F1 NKX2-5 CDX2 AFP
2 11.05 POU5F1 NKX2-5 CDX2 AFP
3
Show member pathways
10.95 SALL4 POU5F1
4 10.39 POU5F1 CDX2

GO Terms for Ovarian Primitive Germ Cell Tumor

Cellular components related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.02 POU5F1 NKX2-5 KAT7 HLX CDX2

Biological processes related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.5 NAPSA GPC3 AFP
2 regulation of transcription, DNA-templated GO:0006355 9.43 SALL4 POU5F1 NKX2-5 KAT7 HLX CDX2
3 blastocyst development GO:0001824 9.26 POU5F1 CDX2
4 anterior/posterior axis specification GO:0009948 9.16 GPC3 CDX2
5 somatic stem cell population maintenance GO:0035019 8.8 SALL4 POU5F1 CDX2

Molecular functions related to Ovarian Primitive Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.26 POU5F1 NKX2-5 HLX CDX2
2 DNA-binding transcription factor activity GO:0003700 9.02 SALL4 POU5F1 NKX2-5 KAT7 CDX2

Sources for Ovarian Primitive Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
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48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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