MCID: OVR123
MIFTS: 30

Ovarian Seromucinous Carcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Seromucinous Carcinoma

MalaCards integrated aliases for Ovarian Seromucinous Carcinoma:

Name: Ovarian Seromucinous Carcinoma 12 15
Mixed Epithelial Carcinoma of Ovary 12
Ovary Mixed Epithelial Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6898
NCIt 50 C40090
UMLS 70 C0279392

Summaries for Ovarian Seromucinous Carcinoma

Disease Ontology : 12 An ovarian carcinoma that is biphasic and has material basis in epithelial and mesenchymal elements.

MalaCards based summary : Ovarian Seromucinous Carcinoma, also known as mixed epithelial carcinoma of ovary, is related to adenocarcinoma and anal paget's disease. An important gene associated with Ovarian Seromucinous Carcinoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. Affiliated tissues include ovary, and related phenotypes are cellular and cardiovascular system

Related Diseases for Ovarian Seromucinous Carcinoma

Diseases related to Ovarian Seromucinous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.5 TP53 KRT7 CDX2 CDKN2A
2 anal paget's disease 10.3 KRT7 CDX2
3 ovary neuroendocrine neoplasm 10.3 KRT7 CDX2
4 gastric signet ring cell adenocarcinoma 10.3 KRT7 CDX2
5 anal gland adenocarcinoma 10.3 KRT7 CDX2
6 ureter adenocarcinoma 10.3 KRT7 CDX2
7 anus adenocarcinoma 10.3 KRT7 CDX2
8 adenosquamous colon carcinoma 10.3 KRT7 CDX2
9 urinary bladder villous adenoma 10.3 KRT7 CDX2
10 vulva adenocarcinoma 10.3 KRT7 CDX2
11 female urethral cancer 10.3 KRT7 CDX2
12 cystitis cystica 10.3 KRT7 CDX2
13 mucinous intrahepatic cholangiocarcinoma 10.3 KRT7 CDX2
14 rectum neuroendocrine neoplasm 10.3 KRT7 CDX2
15 mucinous ovarian cystadenoma 10.3 KRT7 CDX2
16 sigmoid neoplasm 10.3 KRT7 CDX2
17 jejunal cancer 10.3 KRT7 CDX2
18 appendiceal neoplasm 10.3 KRT7 CDX2
19 anal canal adenocarcinoma 10.3 KRT7 CDX2
20 appendix adenocarcinoma 10.3 KRT7 CDX2
21 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 CDX2
22 jejunal adenocarcinoma 10.3 KRT7 CDX2
23 mucinous stomach adenocarcinoma 10.3 KRT7 CDX2
24 vaginal adenoma 10.3 KRT7 CDX2
25 bladder benign neoplasm 10.3 PAX8 KRT7
26 vaginal benign neoplasm 10.3 KRT7 CDX2
27 nephrogenic adenoma of urinary bladder 10.3 PAX8 KRT7
28 nephrogenic adenoma 10.3 PAX8 KRT7
29 rete testis neoplasm 10.3 PAX8 KRT7
30 wolffian duct adenoma 10.3 PAX8 KRT7
31 rete testis adenocarcinoma 10.3 PAX8 KRT7
32 meckel diverticulum 10.2 KRT7 CDX2
33 renal pelvis adenocarcinoma 10.2 PAX8 KRT7
34 duodenum adenocarcinoma 10.2 KRT7 CDX2
35 bladder adenocarcinoma 10.2 KRT7 CDX2
36 urethral diverticulum 10.2 PAX8 KRT7
37 ovarian mucinous adenocarcinoma 10.2 KRT7 CDX2
38 chronic cystitis 10.2 KRT7 CDX2
39 urethral villous adenoma 10.2 PGR KRT7
40 uterus perivascular epithelioid cell tumor 10.2 PAX8 KRT7
41 clear cell hidradenoma 10.2 PAX8 KRT7
42 nephrogenic adenoma of the urethra 10.2 PAX8 KRT7
43 external ear carcinoma 10.2 PGR KRT7
44 spiradenoma 10.2 TP53 KRT7
45 benign metastasizing leiomyoma 10.2 PGR KRT7
46 horseshoe kidney 10.2 KRT7 CDX2
47 breast mucinous carcinoma 10.2 PGR KRT7
48 pancreatic mucinous cystadenoma 10.2 PGR KRT7
49 eccrine papillary adenocarcinoma 10.2 PGR KRT7
50 syringoma 10.2 KRT7 ESR1

Graphical network of the top 20 diseases related to Ovarian Seromucinous Carcinoma:



Diseases related to Ovarian Seromucinous Carcinoma

Symptoms & Phenotypes for Ovarian Seromucinous Carcinoma

MGI Mouse Phenotypes related to Ovarian Seromucinous Carcinoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 CDKN2A CDX2 ESR1 KRT7 PAX8 PGR
2 cardiovascular system MP:0005385 10.07 CDKN2A CDX2 ESR1 PAX8 PGR TP53
3 homeostasis/metabolism MP:0005376 10.06 CDKN2A CDX2 ESR1 KRT7 PAX8 PGR
4 embryo MP:0005380 10.04 CDKN2A CDX2 ESR1 PAX8 PGR TP53
5 endocrine/exocrine gland MP:0005379 10.02 CDKN2A CDX2 ESR1 PAX8 PGR TP53
6 neoplasm MP:0002006 9.85 CDKN2A CDX2 ESR1 PGR TP53 WT1
7 limbs/digits/tail MP:0005371 9.83 CDX2 ESR1 PAX8 PGR TP53
8 muscle MP:0005369 9.8 CDKN2A ESR1 PGR TP53 WT1
9 no phenotypic analysis MP:0003012 9.8 CDKN2A ESR1 PAX8 PGR TP53 WT1
10 normal MP:0002873 9.73 CDX2 ESR1 PAX8 PGR TP53 WT1
11 renal/urinary system MP:0005367 9.55 ESR1 KRT7 PAX8 TP53 WT1
12 reproductive system MP:0005389 9.5 CDKN2A CDX2 ESR1 PAX8 PGR TP53
13 skeleton MP:0005390 9.1 CDKN2A CDX2 ESR1 PAX8 PGR TP53

Drugs & Therapeutics for Ovarian Seromucinous Carcinoma

Search Clinical Trials , NIH Clinical Center for Ovarian Seromucinous Carcinoma

Genetic Tests for Ovarian Seromucinous Carcinoma

Anatomical Context for Ovarian Seromucinous Carcinoma

MalaCards organs/tissues related to Ovarian Seromucinous Carcinoma:

40
Ovary

Publications for Ovarian Seromucinous Carcinoma

Articles related to Ovarian Seromucinous Carcinoma:

# Title Authors PMID Year
1
Three cases of seromucinous carcinoma of the ovary arising in endometriotic cysts. 61
33489701 2021
2
Ovarian Seromucinous Carcinoma With Extensive Bilateral Fallopian Tubes Metastases by the Low-grade Serous Carcinoma Component Mimicking Serous Tubal Intraepithelial Carcinoma: Case Presentation and Literature Review. 61
33323850 2020
3
Seromucinous component in endometrioid endometrial carcinoma as a histological predictor of prognosis. 61
29400013 2018
4
[Clinicopathologic study of seromucinous carcinoma of ovary]. 61
27821232 2016
5
Ovarian seromucinous carcinoma: report of a series of a newly categorized and uncommon neoplasm. 61
25723110 2015

Variations for Ovarian Seromucinous Carcinoma

Expression for Ovarian Seromucinous Carcinoma

Search GEO for disease gene expression data for Ovarian Seromucinous Carcinoma.

Pathways for Ovarian Seromucinous Carcinoma

Pathways related to Ovarian Seromucinous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.98 TP53 PAX8 ESR1 CDKN2A
2 11.83 WT1 TP53 PAX8
3
Show member pathways
11.69 TP53 PGR ESR1 CDX2 CDKN2A
4
Show member pathways
11.58 PGR ESR1 CDKN2A
5 11.02 TP53 ESR1
6 10.98 TP53 ESR1
7 10.91 TP53 CDKN2A
8
Show member pathways
10.66 TP53 CDKN2A
9 10.6 TP53 CDKN2A

GO Terms for Ovarian Seromucinous Carcinoma

Cellular components related to Ovarian Seromucinous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.76 WT1 TP53 PGR PAX8 KRT7 ESR1
2 protein-containing complex GO:0032991 9.56 TP53 ESR1 CDX2 CDKN2A
3 nucleoplasm GO:0005654 9.5 WT1 TP53 PGR PAX8 ESR1 CDX2
4 chromatin GO:0000785 9.1 WT1 TP53 PGR PAX8 ESR1 CDX2

Biological processes related to Ovarian Seromucinous Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.85 WT1 TP53 PGR PAX8 ESR1 CDX2
2 regulation of apoptotic process GO:0042981 9.72 TP53 PAX8 ESR1
3 negative regulation of cell growth GO:0030308 9.67 WT1 TP53 CDKN2A
4 regulation of transcription, DNA-templated GO:0006355 9.63 WT1 TP53 PGR PAX8 ESR1 CDX2
5 positive regulation of cell cycle arrest GO:0071158 9.54 TP53 CDKN2A
6 steroid hormone mediated signaling pathway GO:0043401 9.52 PGR ESR1
7 replicative senescence GO:0090399 9.51 TP53 CDKN2A
8 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.48 TP53 ESR1
9 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.46 TP53 ESR1
10 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 PGR ESR1
11 positive regulation of transcription by RNA polymerase II GO:0045944 9.43 WT1 TP53 PGR PAX8 ESR1 CDKN2A
12 cellular response to gonadotropin stimulus GO:0071371 9.4 WT1 PAX8
13 metanephric S-shaped body morphogenesis GO:0072284 9.32 WT1 PAX8
14 metanephric epithelium development GO:0072207 9.26 WT1 PAX8
15 positive regulation of transcription, DNA-templated GO:0045893 9.1 WT1 TP53 PAX8 ESR1 CDX2 CDKN2A

Molecular functions related to Ovarian Seromucinous Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.87 WT1 TP53 PGR PAX8 ESR1 CDX2
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.85 WT1 TP53 PGR PAX8 ESR1 CDX2
3 zinc ion binding GO:0008270 9.81 WT1 TP53 PGR ESR1
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.73 WT1 TP53 PGR PAX8 ESR1 CDX2
5 transcription regulatory region sequence-specific DNA binding GO:0000976 9.65 WT1 TP53 PAX8
6 sequence-specific DNA binding GO:0043565 9.55 WT1 PGR PAX8 ESR1 CDX2
7 disordered domain specific binding GO:0097718 9.49 TP53 CDKN2A
8 steroid binding GO:0005496 9.46 PGR ESR1
9 steroid hormone receptor activity GO:0003707 9.43 PGR ESR1
10 MDM2/MDM4 family protein binding GO:0097371 9.4 TP53 CDKN2A
11 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.35 WT1 TP53 PGR PAX8 ESR1
12 DNA-binding transcription factor activity GO:0003700 9.1 WT1 TP53 PGR PAX8 ESR1 CDX2

Sources for Ovarian Seromucinous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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