MCID: OVR057
MIFTS: 29

Ovarian Serous Adenofibroma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Serous Adenofibroma

MalaCards integrated aliases for Ovarian Serous Adenofibroma:

Name: Ovarian Serous Adenofibroma 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5474
NCIt 50 C40031
UMLS 70 C1518729

Summaries for Ovarian Serous Adenofibroma

Disease Ontology : 12 An ovarian benign neoplasm that has material basis in glandular and fibrous tissues, with a relatively large proportion of glands and is characterized by the presence of serous fluid.

MalaCards based summary : Ovarian Serous Adenofibroma is related to ovarian serous cystadenofibroma and rete testis adenoma, and has symptoms including abdominal pain An important gene associated with Ovarian Serous Adenofibroma is CALB2 (Calbindin 2), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and DNA Damage Induced 14-3-3Sigma Signaling. Affiliated tissues include thyroid, breast and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovarian Serous Adenofibroma

Diseases related to Ovarian Serous Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 ovarian serous cystadenofibroma 28.8 WNT4 TP53 TG SLC5A5 NCAM1 KRT7
2 rete testis adenoma 10.4 NCAM1 CALB2
3 adult type testicular granulosa cell tumor 10.4 NCAM1 CALB2
4 infected hydrocele 10.4 NCAM1 CALB2
5 alzheimer disease 16 10.3 POMC NR3C1
6 ectopic cushing syndrome 10.3 POMC NR3C1
7 fallopian tube adenocarcinoma 10.3 CALB2 BRCA1
8 ovarian gonadoblastoma 10.3 WNT4 CALB2
9 scleredema adultorum 10.3 POMC NCAM1
10 pituitary-dependent cushing's disease 10.3 POMC NR3C1
11 atypical depressive disorder 10.3 POMC NR3C1
12 corticosteroid-binding globulin deficiency 10.3 POMC NR3C1
13 nelson syndrome 10.3 POMC NR3C1
14 olfactory nerve neoplasm 10.3 POMC NCAM1
15 cranial nerve malignant neoplasm 10.3 POMC NCAM1
16 rete testis neoplasm 10.2 KRT7 CALB2
17 rete testis adenocarcinoma 10.2 KRT7 CALB2
18 bartholin's gland disease 10.2 KRT7 CALB2
19 dermoid cyst of ovary 10.2 CALB2 AMH
20 epididymal neoplasm 10.2 KRT7 CALB2
21 wolffian duct adenocarcinoma 10.2 KRT7 CALB2
22 pericardium cancer 10.2 KRT7 CALB2
23 uterus perivascular epithelioid cell tumor 10.2 KRT7 CALB2
24 cranial nerve neoplasm 10.2 POMC NCAM1
25 nephrogenic adenoma of the urethra 10.2 KRT7 CALB2
26 pancreatic mucinous cystadenoma 10.2 KRT7 CALB2
27 mucinous stomach adenocarcinoma 10.2 KRT7 CALB2
28 pancreatic serous cystadenocarcinoma 10.2 NCAM1 KRT7
29 gallbladder small cell carcinoma 10.2 NCAM1 KRT7
30 thymus clear cell carcinoma 10.2 KRT7 CALB2
31 ureter small cell carcinoma 10.2 NCAM1 KRT7
32 liver leiomyosarcoma 10.2 KRT7 CALB2
33 lung leiomyosarcoma 10.2 KRT7 CALB2
34 urinary bladder small cell neuroendocrine carcinoma 10.2 NCAM1 KRT7
35 sensory organ benign neoplasm 10.2 NCAM1 KRT7
36 ovarian sex-cord stromal tumor 10.2 KRT7 CALB2
37 orbital cellulitis 10.2 NCAM1 KRT7
38 acute orbital inflammation 10.2 NCAM1 KRT7
39 epididymis adenocarcinoma 10.2 KRT7 CALB2
40 epididymis cancer 10.2 KRT7 CALB2
41 dacryocystocele 10.2 NCAM1 KRT7
42 chronic inflammation of lacrimal passage 10.2 NCAM1 KRT7
43 solid adenocarcinoma with mucin production 10.2 NCAM1 KRT7
44 acute stress disorder 10.2 POMC NR3C1
45 prostate neuroendocrine neoplasm 10.2 NCAM1 KRT7
46 primary pigmented nodular adrenocortical disease 10.2 POMC NR3C1 NCAM1
47 epithelioid cell synovial sarcoma 10.2 KRT7 CALB2
48 isthmus cancer 10.2 TG NCAM1
49 urethra clear cell adenocarcinoma 10.2 KRT7 CALB2
50 breast neuroendocrine neoplasm 10.2 NCAM1 KRT7

Graphical network of the top 20 diseases related to Ovarian Serous Adenofibroma:



Diseases related to Ovarian Serous Adenofibroma

Symptoms & Phenotypes for Ovarian Serous Adenofibroma

UMLS symptoms related to Ovarian Serous Adenofibroma:


abdominal pain

GenomeRNAi Phenotypes related to Ovarian Serous Adenofibroma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.58 NR3C1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.58 KRT7
3 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.58 BRCA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.58 BRCA1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.58 NR3C1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.58 NR3C1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.58 BRCA1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.58 NR3C1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.58 KRT7
10 Increased shRNA abundance (Z-score > 2) GR00366-A-204 9.58 BRCA1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 NR3C1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.58 BRCA1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 NR3C1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.58 KRT7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.58 KRT7
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 KRT7
17 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.58 NR3C1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.58 KRT7

MGI Mouse Phenotypes related to Ovarian Serous Adenofibroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.11 AMH BRCA1 HOXA7 HOXA9 HOXD9 NR3C1
2 cellular MP:0005384 10.06 BRCA1 HOXD9 KRT7 NCAM1 NR3C1 POMC
3 nervous system MP:0003631 9.91 BRCA1 CALB2 HOXD9 NCAM1 NR3C1 POMC
4 limbs/digits/tail MP:0005371 9.8 BRCA1 HOXA9 HOXD9 TG TP53 WNT4
5 renal/urinary system MP:0005367 9.7 BRCA1 HOXD9 KRT7 NR3C1 POMC TP53
6 reproductive system MP:0005389 9.56 AMH BRCA1 HOXA9 HOXD9 NR3C1 TG
7 skeleton MP:0005390 9.28 BRCA1 HOXA7 HOXA9 HOXD9 NR3C1 SLC5A5

Drugs & Therapeutics for Ovarian Serous Adenofibroma

Search Clinical Trials , NIH Clinical Center for Ovarian Serous Adenofibroma

Genetic Tests for Ovarian Serous Adenofibroma

Anatomical Context for Ovarian Serous Adenofibroma

MalaCards organs/tissues related to Ovarian Serous Adenofibroma:

40
Thyroid, Breast, Ovary, Lung, Testis, Uterus, Appendix

Publications for Ovarian Serous Adenofibroma

Articles related to Ovarian Serous Adenofibroma:

# Title Authors PMID Year
1
Glucocorticoid resistance syndrome caused by a novel NR3C1 point mutation. 61
30158362 2018
2
Serous adenofibroma of ovary: An eccentric presentation. 61
26881611 2015
3
Calcifications in ovary and endometrium and their neoplasms. 61
12640101 2003

Variations for Ovarian Serous Adenofibroma

Expression for Ovarian Serous Adenofibroma

Search GEO for disease gene expression data for Ovarian Serous Adenofibroma.

Pathways for Ovarian Serous Adenofibroma

Pathways related to Ovarian Serous Adenofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 TP53 POMC NR3C1
2 10.43 TP53 BRCA1
3 9.4 TG SLC5A5

GO Terms for Ovarian Serous Adenofibroma

Biological processes related to Ovarian Serous Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.65 WNT4 TP53 NR3C1 HOXA7 BRCA1
2 anterior/posterior pattern specification GO:0009952 9.5 HOXD9 HOXA9 HOXA7
3 negative regulation of reactive oxygen species metabolic process GO:2000378 9.43 TP53 BRCA1
4 thyroid hormone generation GO:0006590 9.4 TG SLC5A5
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 TP53 BRCA1
6 embryonic skeletal system morphogenesis GO:0048704 9.33 HOXD9 HOXA9 HOXA7
7 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 TP53 POMC NR3C1 HOXD9 HOXA9 HOXA7
8 iodide transport GO:0015705 8.96 TG SLC5A5

Molecular functions related to Ovarian Serous Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 core promoter sequence-specific DNA binding GO:0001046 9.16 TP53 NR3C1
2 hormone activity GO:0005179 9.13 TG POMC AMH
3 DNA-binding transcription factor activity GO:0003700 9.02 TP53 NR3C1 HOXD9 HOXA9 HOXA7

Sources for Ovarian Serous Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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