MCID: OVR108
MIFTS: 21

Ovarian Sex Cord Tumor with Annular Tubules

Categories: Rare diseases

Aliases & Classifications for Ovarian Sex Cord Tumor with Annular Tubules

MalaCards integrated aliases for Ovarian Sex Cord Tumor with Annular Tubules:

Name: Ovarian Sex Cord Tumor with Annular Tubules 54 17
Ovarian Sex Cord-Stromal Tumor 54
Stromal Tumor of Ovary 74

Classifications:



External Ids:

UMLS 74 C0600113

Summaries for Ovarian Sex Cord Tumor with Annular Tubules

NIH Rare Diseases : 54 An ovarian sex cord tumor with annular tubules (SCTAT) is a tumor that grows from cells in the ovaries known as sex cord cells.  As these cells grow, they form tube-like shapes in the tumor.  SCTATs can develop in one or both ovaries, and may cause symptoms such as puberty at an exceptionally young age (precocious puberty), irregular menstrual cycles, or post-menopausal bleeding.  Most ovarian SCTATs are benign. However, because there is a chance that an SCTAT may be malignant, treatment may include surgery to remove the tumor.

MalaCards based summary : Ovarian Sex Cord Tumor with Annular Tubules, also known as ovarian sex cord-stromal tumor, is related to ovarian sex-cord stromal tumor and peutz-jeghers syndrome. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and colon.

Related Diseases for Ovarian Sex Cord Tumor with Annular Tubules

Diseases related to Ovarian Sex Cord Tumor with Annular Tubules via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 ovarian sex-cord stromal tumor 12.8
2 peutz-jeghers syndrome 10.8
3 sex cord-gonadal stromal tumor 10.6
4 adenoma 10.5
5 cervical adenoma malignum 10.5
6 premature ovarian failure 1 10.2
7 endometrial cancer 10.2
8 adenocarcinoma 10.2
9 turner syndrome 10.2
10 precocious puberty 10.2
11 ovarian cancer 10.1
12 pleuropulmonary blastoma 10.1
13 liposarcoma 10.1
14 embryoma 10.1

Graphical network of the top 20 diseases related to Ovarian Sex Cord Tumor with Annular Tubules:



Diseases related to Ovarian Sex Cord Tumor with Annular Tubules

Symptoms & Phenotypes for Ovarian Sex Cord Tumor with Annular Tubules

Drugs & Therapeutics for Ovarian Sex Cord Tumor with Annular Tubules

Drugs for Ovarian Sex Cord Tumor with Annular Tubules (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
3
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
4
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
5
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
6 Antimitotic Agents Phase 3,Phase 2
7 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
8 Albumin-Bound Paclitaxel Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Topoisomerase Inhibitors Phase 3,Phase 2
11 Etoposide phosphate Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 3,Phase 2
13
Bevacizumab Approved, Investigational Phase 2 216974-75-3
14 Angiogenesis Inhibitors Phase 2
15 Immunoglobulin G Phase 2
16 Antibodies Phase 2
17 Immunologic Factors Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Antibodies, Monoclonal Phase 2
20 Angiogenesis Modulating Agents Phase 2
21 Immunoglobulins Phase 2
22 Endothelial Growth Factors Phase 2
23 Mitogens Phase 2
24 Protein Kinase Inhibitors Phase 2
25 Imatinib Mesylate Phase 2 220127-57-1 123596

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 TC or BEP in Treating Patients With Ovarian Malignant Sex Cord-Stromal Tumors Recruiting NCT02429700 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
2 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
4 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
5 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
6 Efficacy and Safety of Bevacizumab (Avastin®) Combined to Weekly Paclitaxel Followed by Bevacizumab (Avastin®) Alone in Patients With Relapsed Ovarian Sex-cord Stromal Tumours (ALIENOR) Active, not recruiting NCT01770301 Phase 2 Paclitaxel;Bevacizumab
7 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Ovarian Sex Cord Tumor with Annular Tubules

Genetic Tests for Ovarian Sex Cord Tumor with Annular Tubules

Anatomical Context for Ovarian Sex Cord Tumor with Annular Tubules

MalaCards organs/tissues related to Ovarian Sex Cord Tumor with Annular Tubules:

42
Ovary, Endothelial, Colon, Cervix

Publications for Ovarian Sex Cord Tumor with Annular Tubules

Articles related to Ovarian Sex Cord Tumor with Annular Tubules:

(show all 25)
# Title Authors Year
1
Prognostic significance of lymphadenectomyin malignant ovarian sex cord stromal tumor: A retrospective cohort study and meta-analysis. ( 29107349 )
2018
2
Co-occurrence of a metastatic mammary liposarcoma and an ovarian sex-cord stromal tumor in a dog. ( 27892865 )
2016
3
Non-Peutz-Jeghers syndrome-associated ovarian sex cord tumor with annular tubules: Report of a malignant case. ( 26807963 )
2016
4
Clinicopathological significance of steroidogenic factor-1 expression in ovarian cancer versus ovarian sex cord stromal tumor. ( 25604140 )
2015
5
Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature. ( 24439718 )
2014
6
Metastatic ovarian sex-cord stromal tumor with annular tubules in a patient without Peutz-Jeghers syndrome. ( 24932834 )
2014
7
Alfa-fetoprotein secreting ovarian sex cord-stromal tumor. ( 23924561 )
2013
8
Endometrial carcinoma and ovarian sex cord tumor with annular tubules in a patient with history of Peutz-Jeghers syndrome and multiple malignancies. ( 21941977 )
2011
9
Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report. ( 19703688 )
2009
10
Ovarian sex cord-stromal tumor, unclassified: case report of endocrinologic findings and review of the literature. ( 16343200 )
2005
11
Conservative management of a uterine tumor resembling an ovarian sex cord-stromal tumor. ( 14751183 )
2004
12
Pathologic quiz case: incidental ovarian lesions in a 48-year-old woman with Peutz-Jeghers syndrome. Ovarian sex cord tumor with annular tubules. ( 14987145 )
2004
13
Colonic adenocarcinoma and bilateral malignant ovarian sex cord tumor with annular tubules in Peutz-Jeghers syndrome. ( 15524052 )
2004
14
Ovarian sex cord tumor with annular tubules in a woman with premature ovarian failure. ( 11730763 )
2001
15
Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report. ( 10786816 )
2000
16
Ovarian sex cord tumor with annular tubules associated with precocious puberty. ( 10918243 )
2000
17
Ovarian sex cord tumor with annular tubules in a patient with Turner syndrome. ( 9539327 )
1998
18
Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum. ( 1612512 )
1992
19
Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum. ( 1916514 )
1991
20
Ovarian sex cord tumor with annular tubules. Report of a case. ( 1776471 )
1991
21
Ovarian sex cord tumor with annular tubules and Peutz-Jeghers syndrome. ( 2379514 )
1990
22
Endocrine and morphological study of a case of ovarian sex-cord tumor with annular tubules in a woman with Peutz-Jeghers syndrome. ( 2900176 )
1988
23
Ovarian sex cord tumor with annular tubules. ( 2417688 )
1986
24
A distinctive ovarian sex cord-stromal tumor causing sexual precocity in the Peutz-Jeghers syndrome. ( 6837833 )
1983
25
Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix. ( 7104978 )
1982

Variations for Ovarian Sex Cord Tumor with Annular Tubules

Expression for Ovarian Sex Cord Tumor with Annular Tubules

Search GEO for disease gene expression data for Ovarian Sex Cord Tumor with Annular Tubules.

Pathways for Ovarian Sex Cord Tumor with Annular Tubules

GO Terms for Ovarian Sex Cord Tumor with Annular Tubules

Sources for Ovarian Sex Cord Tumor with Annular Tubules

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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33 HPO
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35 ICD10 via Orphanet
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47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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