MCID: OVR027
MIFTS: 28

Ovarian Squamous Cell Carcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Squamous Cell Carcinoma

MalaCards integrated aliases for Ovarian Squamous Cell Carcinoma:

Name: Ovarian Squamous Cell Carcinoma 12 15 17 71
Ovarian Squamous Cell Tumor 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5531
NCIt 49 C40093
UMLS 71 C1518739 C2019443

Summaries for Ovarian Squamous Cell Carcinoma

Disease Ontology : 12 An ovarian carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Ovarian Squamous Cell Carcinoma, also known as ovarian squamous cell tumor, is related to cystic teratoma and teratoma. An important gene associated with Ovarian Squamous Cell Carcinoma is CASC11 (Cancer Susceptibility 11), and among its related pathways/superpathways is Pathways in cancer. The drugs Hydroxyurea and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include ovary, colon and cervix.

Related Diseases for Ovarian Squamous Cell Carcinoma

Diseases related to Ovarian Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 cystic teratoma 30.3 KIT CEACAM5 CDKN2A
2 teratoma 30.2 KIT CEACAM5 CDKN2A
3 squamous cell carcinoma 10.5
4 cutaneous solitary mastocytoma 10.4 KIT CLEC11A
5 ceruminous adenocarcinoma 10.4 SLC2A1 KIT
6 vulval paget's disease 10.3 LINC01191 CEACAM5
7 vulva adenocarcinoma 10.3 LINC01191 CEACAM5
8 rectum squamous cell carcinoma 10.3 CASC11 APOLD1
9 renal pelvis adenocarcinoma 10.3 SLC2A1 CEACAM5
10 benign teratoma 10.3
11 endometriosis 10.3
12 mature teratoma 10.3
13 ovarian mixed germ cell neoplasm 10.3 KIT CEACAM5
14 liver leiomyoma 10.2 KIT CEACAM5
15 pancreatic foamy gland adenocarcinoma 10.2 CEACAM5 CCND1
16 malignant anus melanoma 10.2 KIT APOLD1
17 polymorphous low-grade adenocarcinoma 10.2 KIT CCND1
18 warthin tumor 10.2 KIT CEACAM5
19 cutaneous adenocystic carcinoma 10.2 KIT CEACAM5
20 mediastinal cancer 10.2 KIT CEACAM5
21 thyrotoxic exophthalmos 10.1 CCND1 APOLD1
22 ameloblastic carcinoma 10.1 SLC2A1 CDKN2A
23 anus basaloid carcinoma 10.1 KIT CDKN2A
24 cervical adenoid cystic carcinoma 10.1 KIT CDKN2A
25 rectum signet ring adenocarcinoma 10.1 CEACAM5 APOLD1
26 uterus leiomyosarcoma 10.1 KIT CEACAM5
27 heart leiomyosarcoma 10.1 KIT CDKN2A
28 rectosigmoid junction neoplasm 10.1 CEACAM5 APOLD1
29 sigmoid neoplasm 10.1 CEACAM5 APOLD1
30 infected hydrocele 10.1 CRP CCND1
31 external ear carcinoma 10.1 CRP CEACAM5
32 ovarian germ cell cancer 10.1 KIT CEACAM5
33 keratinizing squamous cell carcinoma 10.1 LINC01191 CDKN2A
34 lateral ventricle meningioma 10.1 CRP APOLD1
35 pericardial tuberculosis 10.1 CRP CEACAM5
36 tuberculous peritonitis 10.1 CRP CEACAM5
37 bowenoid papulosis 10.1 CDKN2A CCND1
38 anaerobic meningitis 10.1 CRP APOLD1
39 active peptic ulcer disease 10.1 KIT CRP
40 suppressor of tumorigenicity 3 10.1
41 ovarian brenner tumor 10.1
42 esophagus verrucous carcinoma 10.1 CDKN2A CCND1
43 linitis plastica 10.1 CEACAM5 APOLD1
44 vulva squamous cell carcinoma 10.1 LINC01191 CDKN2A
45 ascending colon cancer 10.1 CEACAM5 APOLD1
46 parotid gland adenoid cystic carcinoma 10.1 CEACAM5 CDKN2A
47 fibrosarcoma of bone 10.1 KIT CDKN2A
48 vagina leiomyoma 10.1 CEACAM5 CDKN2A
49 gastrointestinal tuberculosis 10.1 CRP CEACAM5
50 vulvar eccrine porocarcinoma 10.0 CEACAM5 CDKN2A

Graphical network of the top 20 diseases related to Ovarian Squamous Cell Carcinoma:



Diseases related to Ovarian Squamous Cell Carcinoma

Symptoms & Phenotypes for Ovarian Squamous Cell Carcinoma

Drugs & Therapeutics for Ovarian Squamous Cell Carcinoma

Drugs for Ovarian Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 1 127-07-1 3657
2
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
3
carbamide peroxide Approved Phase 1 124-43-6
4 Alkylating Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Multicenter Phase I Trial of Hydroxyurea in Combination With Dose-Intense Temozolomide in Recurrent Glioblastoma Recruiting NCT03463733 Phase 1 Hydroxyurea;Temozolomide

Search NIH Clinical Center for Ovarian Squamous Cell Carcinoma

Genetic Tests for Ovarian Squamous Cell Carcinoma

Anatomical Context for Ovarian Squamous Cell Carcinoma

MalaCards organs/tissues related to Ovarian Squamous Cell Carcinoma:

40
Ovary, Colon, Cervix, Bone, Heart, Tonsil, Liver

Publications for Ovarian Squamous Cell Carcinoma

Articles related to Ovarian Squamous Cell Carcinoma:

(show all 28)
# Title Authors PMID Year
1
Overexpression of CASC11 in ovarian squamous cell carcinoma mediates the development of cancer cell resistance to chemotherapy. 61
31181314 2019
2
MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake. 61
30304996 2018
3
A case of pure-type ovarian squamous cell carcinoma producing granulocyte-colony stimulating factor. 61
29159261 2017
4
Long-term recurrence-free survival of a patient with advanced pure primary ovarian squamous cell carcinoma treated with dose-dense paclitaxel combined with carboplatin. 61
29184868 2017
5
Pure Primary Ovarian Squamous Cell Carcinoma Perforating the Rectum. 61
28316851 2017
6
Case of pure ovarian squamous cell carcinoma resistant to combination chemotherapy with paclitaxel and carboplatin but responsive to monotherapy with weekly irinotecan. 61
25511544 2015
7
Pure primary ovarian squamous cell carcinoma: A case report and review of the literature. 61
25435984 2015
8
Clinical experience in ovarian squamous cell carcinoma arising from mature cystic teratoma: A rare entity. 61
25105100 2014
9
De novo Ovarian Squamous Cell Carcinoma. A Case Report and Review of Literature. 61
24426735 2013
10
Bilateral ovarian squamous cell carcinoma with an antecedent dermoid cyst in the left ovary. 61
21518128 2011
11
Ultrasonography for leukocytosis or elevated C-reactive protein. 61
21937369 2011
12
Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report. 61
21467082 2011
13
Ovarian squamous cell carcinoma arising from mature cystic teratoma. 61
21684828 2011
14
Unusual form of superficial spreading squamous cell carcinoma of cervix involving the endometrium, bilateral tubes and ovaries: a case report with literature review. 61
20852876 2011
15
A case of squamous cell carcinoma arising from endometriosis of the ovary. 61
22053674 2011
16
Metastatic ovarian squamous cell carcinoma. 61
18465040 2008
17
De novo primary squamous cell carcinoma of the ovary: a case of a rare malignancy with an aggressive clinical course. 61
18655408 2008
18
HPV induced ovarian squamous cell carcinoma: case report and review of the literature. 61
17333225 2007
19
[Primary squamous cell carcinoma of the ovary]. 61
16324442 2005
20
A case of pure-type ovarian squamous cell carcinoma for which combination chemotherapy consisting of paclitaxel and carboplatin was not effective. 61
15790463 2005
21
A case of rapidly growing ovarian squamous cell carcinoma successfully controlled by weekly paclitaxel-carboplatin administration. 61
11104632 2000
22
Diagnosis of squamous cell carcinoma arising from mature cystic teratoma of the ovary. 61
9610706 1998
23
Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. 61
8651358 1996
24
Pure primary ovarian squamous cell carcinoma. 61
3276582 1988
25
[A case report of ovarian squamous cell carcinoma developing into a dermoid cyst with malignant transformation--immunohistochemical study]. 61
2447309 1987
26
Squamous cell carcinoma of the ovary. 61
3632305 1987
27
Ovarian squamous cell carcinoma derived from a dermoid cyst presenting as vaginal metastasis and the implication of its steroid receptor levels--two case reports. 61
3943751 1986
28
Squamous cell carcinoma arising from an epidermoid cyst in the ovary of a rat treated with 7,12-dimethylbenz[a]anthracene. 61
6811356 1982

Variations for Ovarian Squamous Cell Carcinoma

Expression for Ovarian Squamous Cell Carcinoma

Search GEO for disease gene expression data for Ovarian Squamous Cell Carcinoma.

Pathways for Ovarian Squamous Cell Carcinoma

Pathways related to Ovarian Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.83 SLC2A1 MSH6 KIT FGFR4 CDKN2A CCND1

GO Terms for Ovarian Squamous Cell Carcinoma

Biological processes related to Ovarian Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell division GO:0048103 8.62 KIT CDKN2A

Sources for Ovarian Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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