Ovarian Stromal Hyperthecosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovarian Stromal Hyperthecosis

MalaCards integrated aliases for Ovarian Stromal Hyperthecosis:

Name: Ovarian Stromal Hyperthecosis ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7347

NCIt ⁵⁰ C40446

UMLS ⁷⁰ C1518743

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Summaries for Ovarian Stromal Hyperthecosis

Disease Ontology : ¹² An ovarian disease that is characterized by the presence of nests of luteinized theca cells scattered throughout the ovary, which results in severe hyperandrogenism and insulin resistance. Clinical symptoms involve slowly progressive acne, hirsutism, virilization.

MalaCards based summary : Ovarian Stromal Hyperthecosis is related to hyperandrogenism and acanthosis nigricans. An important gene associated with Ovarian Stromal Hyperthecosis is CDH1 (Cadherin 1), and among its related pathways/superpathways are Endometrial cancer and Ras signaling pathway. Affiliated tissues include ovary and uterus.

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Related Diseases for Ovarian Stromal Hyperthecosis

Diseases related to Ovarian Stromal Hyperthecosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)

#	Related Disease	Score	Top Affiliating Genes
1	hyperandrogenism	10.2
2	acanthosis nigricans	10.1
3	type 2 diabetes mellitus	10.1
4	endometrial cancer	10.1
5	fibroma	10.1
6	ovarian disease	10.1
7	polycystic ovary syndrome	10.1
8	fibromatosis	10.1
9	hair-an syndrome	10.1
10	ovarian fibrothecoma	10.1
11	gastrointestinal system benign neoplasm	9.8	INS CDH1
12	colorectal adenoma	9.8	INS CDH1
13	gallbladder disease	9.7	INS CDH1
14	teratoma	9.7	INS CDH1
15	cell type benign neoplasm	9.7	INS CDH1
16	autosomal dominant polycystic kidney disease	9.7	INS CDH1
17	polycystic kidney disease	9.7	INS CDH1
18	colon adenocarcinoma	9.6	INS CDH1
19	eye disease	9.6	INS CDH1
20	skin carcinoma	9.5	INS CDH1

Graphical network of the top 20 diseases related to Ovarian Stromal Hyperthecosis:

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Symptoms & Phenotypes for Ovarian Stromal Hyperthecosis

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Drugs & Therapeutics for Ovarian Stromal Hyperthecosis

Search Clinical Trials , NIH Clinical Center for Ovarian Stromal Hyperthecosis

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Genetic Tests for Ovarian Stromal Hyperthecosis

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Anatomical Context for Ovarian Stromal Hyperthecosis

MalaCards organs/tissues related to Ovarian Stromal Hyperthecosis:

⁴⁰

Ovary, Uterus

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Publications for Ovarian Stromal Hyperthecosis

Articles related to Ovarian Stromal Hyperthecosis:

(show all 16)

#	Title	Authors	PMID	Year
1	Value of selective venous catheterization in the diagnosis of hyperandrogenism. ⁶¹	Hickman LC...Falcone T	29100622	2017
2	Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies. ⁶¹	Yance VRV...Domenice S	28432270	2017
3	Magnetic resonance imaging findings of ovarian stromal hyperthecosis. ⁶¹	Fujii S...Ogawa T	19863423	2009
4	Ovarian stromal hyperthecosis: sonographic features and histologic associations. ⁶¹	Brown DL...Vella A	19389897	2009
5	[Clinical, hormonal and histological features in ovarian stromal hyperthecosis]. ⁶¹	Abuladze MV...Sharabidze NG	17077467	2006
6	Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis. ⁶¹	Sharabidze N...Sabakhtarashvili M	16575127	2006
7	Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis. ⁶¹	Sharabidze N...Burkadze G	16444023	2005
8	Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries. ⁶¹	Piaditis G...Kovacs K	15687346	2005
9	[Ovarian stromal hyperthecosis and concurrent endometrial carcinoma of the uterus]. ⁶¹	Kuntscherova J...Jahnova H	10953479	2000
10	Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. ⁶¹	Mantzoros CS...Levy J	7650669	1995
11	Pathological case of the month. Ovarian stromal hyperthecosis. ⁶¹	Schwartz ID...Gilbert-Barness E	8488812	1993
12	Virilization in a postmenopausal woman due to ovarian stromal hyperthecosis. ⁶¹	Goldman JM...Kapadia LJ	2062784	1991
13	Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. ⁶¹	Tuffnell DJ	2306435	1990
14	Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. Case report. ⁶¹	Leedman PJ...Martin FI	2553097	1989
15	Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. ⁶¹	Dunaif A...Crowley WF	3900841	1985
16	Postmenopausal virilization due to ovarian stromal hyperthecosis. ⁶¹	Braithwaite SS...Avila TD	220276	1978

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Genes for Ovarian Stromal Hyperthecosis

Genes related to Ovarian Stromal Hyperthecosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CDH1	Cadherin 1	Protein Coding	4.84	DISEASES inferred ¹⁵
2	INS	Insulin	Protein Coding	3.98	DISEASES inferred ¹⁵

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Variations for Ovarian Stromal Hyperthecosis

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Expression for Ovarian Stromal Hyperthecosis

Search GEO for disease gene expression data for Ovarian Stromal Hyperthecosis.

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Pathways for Ovarian Stromal Hyperthecosis

Pathways related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	11.9	INS CDH1
2	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	11.6	INS CDH1
3	Arf6 trafficking events ¹	10.27	INS CDH1

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GO Terms for Ovarian Stromal Hyperthecosis

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Sources for Ovarian Stromal Hyperthecosis

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