Ovarian Stromal Hyperthecosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovarian Stromal Hyperthecosis

MalaCards integrated aliases for Ovarian Stromal Hyperthecosis:

Name: Ovarian Stromal Hyperthecosis ¹¹ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7347

NCIt ⁴⁹ C40446

UMLS ⁷¹ C1518743

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Summaries for Ovarian Stromal Hyperthecosis

Disease Ontology: ¹¹ An ovarian disease that is characterized by the presence of nests of luteinized theca cells scattered throughout the ovary, which results in severe hyperandrogenism and insulin resistance. Clinical symptoms involve slowly progressive acne, hirsutism, virilization.

MalaCards based summary: Ovarian Stromal Hyperthecosis is related to endometrial cancer and type 2 diabetes mellitus. An important gene associated with Ovarian Stromal Hyperthecosis is BCL2 (BCL2 Apoptosis Regulator), and among its related pathways/superpathways are TGF-Beta Pathway and Hepatocyte growth factor receptor signaling. Affiliated tissues include ovary and uterus, and related phenotype is digestive/alimentary.

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Related Diseases for Ovarian Stromal Hyperthecosis

Diseases related to Ovarian Stromal Hyperthecosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Related Disease	Score	Top Affiliating Genes
1	endometrial cancer	29.4	INS CDH1 BCL2
2	type 2 diabetes mellitus	10.3
3	polycystic ovary syndrome	10.3
4	hyperandrogenism	10.3
5	acanthosis nigricans	10.1
6	polycystic ovary syndrome 1	10.1
7	fibroma	10.1
8	ovarian disease	10.1
9	endometrial adenocarcinoma	10.1
10	fibromatosis	10.1
11	ovarian fibrothecoma	10.1
12	diabetic encephalopathy	10.0	INS BCL2
13	uterine benign neoplasm	10.0	INS BCL2
14	reproductive organ benign neoplasm	10.0	INS BCL2
15	transient cerebral ischemia	10.0	INS BCL2
16	amelogenesis imperfecta, type ig	9.9	INS BCL2
17	amelogenesis imperfecta	9.9	INS BCL2
18	prolactinoma	9.8	INS CDH1
19	hypopharynx cancer	9.8	CDH1 BCL2
20	estrogen-receptor negative breast cancer	9.8	CDH1 BCL2
21	respiratory system benign neoplasm	9.8	CDH1 BCL2
22	oropharynx cancer	9.8	CDH1 BCL2
23	pre-malignant neoplasm	9.8	CDH1 BCL2
24	colorectal adenocarcinoma	9.8	CDH1 BCL2
25	intestinal benign neoplasm	9.8	CDH1 BCL2
26	keratoacanthoma	9.8	CDH1 BCL2
27	lymphangioma	9.8	CDH1 BCL2
28	malignant ovarian surface epithelial-stromal neoplasm	9.8	CDH1 BCL2
29	sarcoma, synovial	9.8	CDH1 BCL2
30	malignant pleural mesothelioma	9.8	CDH1 BCL2
31	cervix carcinoma	9.8	CDH1 BCL2
32	tongue disease	9.8	CDH1 BCL2
33	li-fraumeni syndrome	9.8	CDH1 BCL2
34	tongue carcinoma	9.8	CDH1 BCL2
35	thyroid gland anaplastic carcinoma	9.8	CDH1 BCL2
36	breast ductal carcinoma	9.7	CDH1 BCL2
37	papilloma	9.7	CDH1 BCL2
38	transitional cell carcinoma	9.7	CDH1 BCL2
39	common variable immunodeficiency	9.7	INS BCL2
40	gastric adenocarcinoma	9.7	CDH1 BCL2
41	hemangioma	9.7	CDH1 BCL2
42	adenoid cystic carcinoma	9.7	CDH1 BCL2
43	laryngeal squamous cell carcinoma	9.7	CDH1 BCL2
44	melanoma, uveal	9.7	CDH1 BCL2
45	hepatoblastoma	9.7	CDH1 BCL2
46	skin carcinoma	9.7	CDH1 BCL2
47	bile duct cancer	9.7	CDH1 BCL2
48	thyroid gland cancer	9.7	CDH1 BCL2
49	adenoma	9.6	CDH1 BCL2
50	wilms tumor 1	9.6	CDH1 BCL2

Graphical network of the top 20 diseases related to Ovarian Stromal Hyperthecosis:

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Symptoms & Phenotypes for Ovarian Stromal Hyperthecosis

MGI Mouse Phenotypes related to Ovarian Stromal Hyperthecosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.8	BCL2 CDH1 INS

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Drugs & Therapeutics for Ovarian Stromal Hyperthecosis

Search Clinical Trials, NIH Clinical Center for Ovarian Stromal Hyperthecosis

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Genetic Tests for Ovarian Stromal Hyperthecosis

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Anatomical Context for Ovarian Stromal Hyperthecosis

Organs/tissues related to Ovarian Stromal Hyperthecosis:

MalaCards : Ovary, Uterus

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Publications for Ovarian Stromal Hyperthecosis

Articles related to Ovarian Stromal Hyperthecosis:

(show all 16)

#	Title	Authors	PMID	Year
1	Value of selective venous catheterization in the diagnosis of hyperandrogenism. ⁶²	Hickman LC...Falcone T	29100622	2017
2	Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies. ⁶²	Yance VRV...Domenice S	28432270	2017
3	Magnetic resonance imaging findings of ovarian stromal hyperthecosis. ⁶²	Fujii S...Ogawa T	19863423	2009
4	Ovarian stromal hyperthecosis: sonographic features and histologic associations. ⁶²	Brown DL...Vella A	19389897	2009
5	[Clinical, hormonal and histological features in ovarian stromal hyperthecosis]. ⁶²	Abuladze MV...Sharabidze NG	17077467	2006
6	Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis. ⁶²	Sharabidze N...Sabakhtarashvili M	16575127	2006
7	Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis. ⁶²	Sharabidze N...Burkadze G	16444023	2005
8	Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries. ⁶²	Piaditis G...Kovacs K	15687346	2005
9	[Ovarian stromal hyperthecosis and concurrent endometrial carcinoma of the uterus]. ⁶²	Kuntscherova J...Jahnova H	10953479	2000
10	Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. ⁶²	Mantzoros CS...Levy J	7650669	1995
11	Pathological case of the month. Ovarian stromal hyperthecosis. ⁶²	Schwartz ID...Gilbert-Barness E	8488812	1993
12	Virilization in a postmenopausal woman due to ovarian stromal hyperthecosis. ⁶²	Goldman JM...Kapadia LJ	2062784	1991
13	Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. ⁶²	Tuffnell DJ	2306435	1990
14	Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. Case report. ⁶²	Leedman PJ...Martin FI	2553097	1989
15	Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. ⁶²	Dunaif A...Crowley WF	3900841	1985
16	Postmenopausal virilization due to ovarian stromal hyperthecosis. ⁶²	Braithwaite SS...Avila TD	220276	1978

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Genes for Ovarian Stromal Hyperthecosis

Genes related to Ovarian Stromal Hyperthecosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BCL2	BCL2 Apoptosis Regulator	Protein Coding	4.58	DISEASES inferred ¹⁴
2	CDH1	Cadherin 1	Protein Coding	4.07	DISEASES inferred ¹⁴
3	INS	Insulin	Protein Coding	3.25	DISEASES inferred ¹⁴

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Variations for Ovarian Stromal Hyperthecosis

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Expression for Ovarian Stromal Hyperthecosis

Search GEO for disease gene expression data for Ovarian Stromal Hyperthecosis.

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Pathways for Ovarian Stromal Hyperthecosis

Pathways related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	12.87	INS CDH1 BCL2
2	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	11.91	CDH1 BCL2
3	Autophagy pathway ⁶⁷ Show member pathways AKT Signaling Pathway ⁶⁷	11.91	INS BCL2
4	Integrated breast cancer pathway ⁷⁴	11.58	CDH1 BCL2
5	Presenilin-Mediated Signaling ⁶⁴	11.52	CDH1 BCL2
6	Autophagy ⁷⁴ Show member pathways Autophagy during CoV infection ⁷⁴ Host-pathogen interaction of human coronaviruses - autophagy ⁷⁴ Nanoparticle triggered autophagic cell death ⁷⁴ Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway ⁷⁴	11.43	INS BCL2
7	Malignant pleural mesothelioma ⁷⁴	11.41	INS CDH1 BCL2
8	Senescence and autophagy in cancer ⁷⁴	11.28	INS BCL2
9	ATF-2 transcription factor network ⁶¹	10.91	INS BCL2
10	Arf6 trafficking events ⁶¹	10.63	INS CDH1

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GO Terms for Ovarian Stromal Hyperthecosis

Biological processes related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell growth	GO:0030307	9.56	INS BCL2
2	regulation of protein localization	GO:0032880	9.46	INS BCL2
3	response to toxic substance	GO:0009636	9.26	CDH1 BCL2
4	regulation of transmembrane transporter activity	GO:0022898	8.92	INS BCL2

Molecular functions related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:0002020	8.92	INS BCL2

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Sources for Ovarian Stromal Hyperthecosis

¹ BitterDB

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²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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³⁰ HPO

³¹ ICD10

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³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

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⁴⁰ MedGen

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⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

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⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: OVR001 MIFTS: 23	Ovarian Stromal Hyperthecosis Categories: Endocrine diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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