MCID: OVR001
MIFTS: 17

Ovarian Stromal Hyperthecosis

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovarian Stromal Hyperthecosis

MalaCards integrated aliases for Ovarian Stromal Hyperthecosis:

Name: Ovarian Stromal Hyperthecosis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7347
NCIt 50 C40446
UMLS 70 C1518743

Summaries for Ovarian Stromal Hyperthecosis

Disease Ontology : 12 An ovarian disease that is characterized by the presence of nests of luteinized theca cells scattered throughout the ovary, which results in severe hyperandrogenism and insulin resistance. Clinical symptoms involve slowly progressive acne, hirsutism, virilization.

MalaCards based summary : Ovarian Stromal Hyperthecosis is related to hyperandrogenism and acanthosis nigricans. An important gene associated with Ovarian Stromal Hyperthecosis is CDH1 (Cadherin 1), and among its related pathways/superpathways are Endometrial cancer and Ras signaling pathway. Affiliated tissues include ovary and uterus.

Related Diseases for Ovarian Stromal Hyperthecosis

Diseases related to Ovarian Stromal Hyperthecosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 hyperandrogenism 10.2
2 acanthosis nigricans 10.1
3 type 2 diabetes mellitus 10.1
4 endometrial cancer 10.1
5 fibroma 10.1
6 ovarian disease 10.1
7 polycystic ovary syndrome 10.1
8 fibromatosis 10.1
9 hair-an syndrome 10.1
10 ovarian fibrothecoma 10.1
11 gastrointestinal system benign neoplasm 9.8 INS CDH1
12 colorectal adenoma 9.8 INS CDH1
13 gallbladder disease 9.7 INS CDH1
14 teratoma 9.7 INS CDH1
15 cell type benign neoplasm 9.7 INS CDH1
16 autosomal dominant polycystic kidney disease 9.7 INS CDH1
17 polycystic kidney disease 9.7 INS CDH1
18 colon adenocarcinoma 9.6 INS CDH1
19 eye disease 9.6 INS CDH1
20 skin carcinoma 9.5 INS CDH1

Graphical network of the top 20 diseases related to Ovarian Stromal Hyperthecosis:



Diseases related to Ovarian Stromal Hyperthecosis

Symptoms & Phenotypes for Ovarian Stromal Hyperthecosis

Drugs & Therapeutics for Ovarian Stromal Hyperthecosis

Search Clinical Trials , NIH Clinical Center for Ovarian Stromal Hyperthecosis

Genetic Tests for Ovarian Stromal Hyperthecosis

Anatomical Context for Ovarian Stromal Hyperthecosis

MalaCards organs/tissues related to Ovarian Stromal Hyperthecosis:

40
Ovary, Uterus

Publications for Ovarian Stromal Hyperthecosis

Articles related to Ovarian Stromal Hyperthecosis:

(show all 16)
# Title Authors PMID Year
1
Value of selective venous catheterization in the diagnosis of hyperandrogenism. 61
29100622 2017
2
Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies. 61
28432270 2017
3
Magnetic resonance imaging findings of ovarian stromal hyperthecosis. 61
19863423 2009
4
Ovarian stromal hyperthecosis: sonographic features and histologic associations. 61
19389897 2009
5
[Clinical, hormonal and histological features in ovarian stromal hyperthecosis]. 61
17077467 2006
6
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis. 61
16575127 2006
7
Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis. 61
16444023 2005
8
Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries. 61
15687346 2005
9
[Ovarian stromal hyperthecosis and concurrent endometrial carcinoma of the uterus]. 61
10953479 2000
10
Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. 61
7650669 1995
11
Pathological case of the month. Ovarian stromal hyperthecosis. 61
8488812 1993
12
Virilization in a postmenopausal woman due to ovarian stromal hyperthecosis. 61
2062784 1991
13
Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. 61
2306435 1990
14
Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. Case report. 61
2553097 1989
15
Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. 61
3900841 1985
16
Postmenopausal virilization due to ovarian stromal hyperthecosis. 61
220276 1978

Variations for Ovarian Stromal Hyperthecosis

Expression for Ovarian Stromal Hyperthecosis

Search GEO for disease gene expression data for Ovarian Stromal Hyperthecosis.

Pathways for Ovarian Stromal Hyperthecosis

Pathways related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.9 INS CDH1
2
Show member pathways
11.6 INS CDH1
3 10.27 INS CDH1

GO Terms for Ovarian Stromal Hyperthecosis

Sources for Ovarian Stromal Hyperthecosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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