MCID: OVR001
MIFTS: 23

Ovarian Stromal Hyperthecosis

Categories: Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Ovarian Stromal Hyperthecosis

MalaCards integrated aliases for Ovarian Stromal Hyperthecosis:

Name: Ovarian Stromal Hyperthecosis 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:7347
NCIt 49 C40446
UMLS 71 C1518743

Summaries for Ovarian Stromal Hyperthecosis

Disease Ontology: 11 An ovarian disease that is characterized by the presence of nests of luteinized theca cells scattered throughout the ovary, which results in severe hyperandrogenism and insulin resistance. Clinical symptoms involve slowly progressive acne, hirsutism, virilization.

MalaCards based summary: Ovarian Stromal Hyperthecosis is related to endometrial cancer and type 2 diabetes mellitus. An important gene associated with Ovarian Stromal Hyperthecosis is BCL2 (BCL2 Apoptosis Regulator), and among its related pathways/superpathways are TGF-Beta Pathway and Hepatocyte growth factor receptor signaling. Affiliated tissues include ovary and uterus, and related phenotype is digestive/alimentary.

Related Diseases for Ovarian Stromal Hyperthecosis

Diseases related to Ovarian Stromal Hyperthecosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 endometrial cancer 29.4 INS CDH1 BCL2
2 type 2 diabetes mellitus 10.3
3 polycystic ovary syndrome 10.3
4 hyperandrogenism 10.3
5 acanthosis nigricans 10.1
6 polycystic ovary syndrome 1 10.1
7 fibroma 10.1
8 ovarian disease 10.1
9 endometrial adenocarcinoma 10.1
10 fibromatosis 10.1
11 ovarian fibrothecoma 10.1
12 diabetic encephalopathy 10.0 INS BCL2
13 uterine benign neoplasm 10.0 INS BCL2
14 reproductive organ benign neoplasm 10.0 INS BCL2
15 transient cerebral ischemia 10.0 INS BCL2
16 amelogenesis imperfecta, type ig 9.9 INS BCL2
17 amelogenesis imperfecta 9.9 INS BCL2
18 prolactinoma 9.8 INS CDH1
19 hypopharynx cancer 9.8 CDH1 BCL2
20 estrogen-receptor negative breast cancer 9.8 CDH1 BCL2
21 respiratory system benign neoplasm 9.8 CDH1 BCL2
22 oropharynx cancer 9.8 CDH1 BCL2
23 pre-malignant neoplasm 9.8 CDH1 BCL2
24 colorectal adenocarcinoma 9.8 CDH1 BCL2
25 intestinal benign neoplasm 9.8 CDH1 BCL2
26 keratoacanthoma 9.8 CDH1 BCL2
27 lymphangioma 9.8 CDH1 BCL2
28 malignant ovarian surface epithelial-stromal neoplasm 9.8 CDH1 BCL2
29 sarcoma, synovial 9.8 CDH1 BCL2
30 malignant pleural mesothelioma 9.8 CDH1 BCL2
31 cervix carcinoma 9.8 CDH1 BCL2
32 tongue disease 9.8 CDH1 BCL2
33 li-fraumeni syndrome 9.8 CDH1 BCL2
34 tongue carcinoma 9.8 CDH1 BCL2
35 thyroid gland anaplastic carcinoma 9.8 CDH1 BCL2
36 breast ductal carcinoma 9.7 CDH1 BCL2
37 papilloma 9.7 CDH1 BCL2
38 transitional cell carcinoma 9.7 CDH1 BCL2
39 common variable immunodeficiency 9.7 INS BCL2
40 gastric adenocarcinoma 9.7 CDH1 BCL2
41 hemangioma 9.7 CDH1 BCL2
42 adenoid cystic carcinoma 9.7 CDH1 BCL2
43 laryngeal squamous cell carcinoma 9.7 CDH1 BCL2
44 melanoma, uveal 9.7 CDH1 BCL2
45 hepatoblastoma 9.7 CDH1 BCL2
46 skin carcinoma 9.7 CDH1 BCL2
47 bile duct cancer 9.7 CDH1 BCL2
48 thyroid gland cancer 9.7 CDH1 BCL2
49 adenoma 9.6 CDH1 BCL2
50 wilms tumor 1 9.6 CDH1 BCL2

Graphical network of the top 20 diseases related to Ovarian Stromal Hyperthecosis:



Diseases related to Ovarian Stromal Hyperthecosis

Symptoms & Phenotypes for Ovarian Stromal Hyperthecosis

MGI Mouse Phenotypes related to Ovarian Stromal Hyperthecosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 BCL2 CDH1 INS

Drugs & Therapeutics for Ovarian Stromal Hyperthecosis

Search Clinical Trials, NIH Clinical Center for Ovarian Stromal Hyperthecosis

Genetic Tests for Ovarian Stromal Hyperthecosis

Anatomical Context for Ovarian Stromal Hyperthecosis

Organs/tissues related to Ovarian Stromal Hyperthecosis:

MalaCards : Ovary, Uterus

Publications for Ovarian Stromal Hyperthecosis

Articles related to Ovarian Stromal Hyperthecosis:

(show all 16)
# Title Authors PMID Year
1
Value of selective venous catheterization in the diagnosis of hyperandrogenism. 62
29100622 2017
2
Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies. 62
28432270 2017
3
Magnetic resonance imaging findings of ovarian stromal hyperthecosis. 62
19863423 2009
4
Ovarian stromal hyperthecosis: sonographic features and histologic associations. 62
19389897 2009
5
[Clinical, hormonal and histological features in ovarian stromal hyperthecosis]. 62
17077467 2006
6
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis. 62
16575127 2006
7
Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis. 62
16444023 2005
8
Ectopic bioactive luteinizing hormone secretion by a pancreatic endocrine tumor, manifested as luteinized granulosa-thecal cell tumor of the ovaries. 62
15687346 2005
9
[Ovarian stromal hyperthecosis and concurrent endometrial carcinoma of the uterus]. 62
10953479 2000
10
Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. 62
7650669 1995
11
Pathological case of the month. Ovarian stromal hyperthecosis. 62
8488812 1993
12
Virilization in a postmenopausal woman due to ovarian stromal hyperthecosis. 62
2062784 1991
13
Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. 62
2306435 1990
14
Virilizing nodular ovarian stromal hyperthecosis, diabetes mellitus and insulin resistance in a postmenopausal woman. Case report. 62
2553097 1989
15
Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. 62
3900841 1985
16
Postmenopausal virilization due to ovarian stromal hyperthecosis. 62
220276 1978

Variations for Ovarian Stromal Hyperthecosis

Expression for Ovarian Stromal Hyperthecosis

Search GEO for disease gene expression data for Ovarian Stromal Hyperthecosis.

Pathways for Ovarian Stromal Hyperthecosis

Pathways related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 INS CDH1 BCL2
2
Show member pathways
11.91 CDH1 BCL2
3
Show member pathways
11.91 INS BCL2
4 11.58 CDH1 BCL2
5 11.52 CDH1 BCL2
6
Show member pathways
11.43 INS BCL2
7 11.41 INS CDH1 BCL2
8 11.28 INS BCL2
9 10.91 INS BCL2
10 10.63 INS CDH1

GO Terms for Ovarian Stromal Hyperthecosis

Biological processes related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell growth GO:0030307 9.56 INS BCL2
2 regulation of protein localization GO:0032880 9.46 INS BCL2
3 response to toxic substance GO:0009636 9.26 CDH1 BCL2
4 regulation of transmembrane transporter activity GO:0022898 8.92 INS BCL2

Molecular functions related to Ovarian Stromal Hyperthecosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.92 INS BCL2

Sources for Ovarian Stromal Hyperthecosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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