MCID: OVR060
MIFTS: 45

Ovary Epithelial Cancer

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovary Epithelial Cancer

MalaCards integrated aliases for Ovary Epithelial Cancer:

Name: Ovary Epithelial Cancer 12 15
Epithelial Tumor of Ovary 12 73
Ovarian Surface Epithelial-Stromal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2152
NCIt 50 C4381
UMLS 73 C0341823

Summaries for Ovary Epithelial Cancer

Disease Ontology : 12 An ovarian cancer that is derives from ovarian surface epithelium.

MalaCards based summary : Ovary Epithelial Cancer, also known as epithelial tumor of ovary, is related to krukenberg carcinoma and ovarian mucinous neoplasm. An important gene associated with Ovary Epithelial Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. Affiliated tissues include ovary, liver and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Ovary Epithelial Cancer

Diseases related to Ovary Epithelial Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 krukenberg carcinoma 32.2 HNF1B KRT7
2 ovarian mucinous neoplasm 31.9 CEACAM5 KRT7 WT1
3 malignant ovarian surface epithelial-stromal neoplasm 30.0 ACSBG1 AKT1 AREG ARID1A BRCA1 BRCA2
4 mixed epithelial tumor of ovary 12.4
5 borderline epithelial tumor of ovary 12.3
6 endometrioid ovary carcinoma 11.1
7 ovarian papillary neoplasm 11.1
8 malignant ovarian mixed epithelial neoplasm 11.1
9 breast reconstruction 10.4 BRCA1 BRCA2
10 nosophobia 10.4 BRCA1 BRCA2
11 gastric papillary adenocarcinoma 10.4 ERBB2 TP53
12 cancerophobia 10.4 BRCA1 BRCA2
13 breast medullary carcinoma 10.4 BRCA1 ERBB2
14 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
15 adult hepatocellular carcinoma 10.4 PIK3CA TP53
16 cerebral convexity meningioma 10.4 CDH1 TP53
17 cerebellar angioblastoma 10.4 TP53 WT1
18 breast cystic hypersecretory carcinoma 10.4 CDH1 ERBB2
19 large intestine adenocarcinoma 10.4 CDH1 KRT7
20 linitis plastica 10.4 CDH1 KRT7
21 benign mesothelioma 10.4 KRT7 WT1
22 hyperplastic polyposis syndrome 10.4 KRAS TP53
23 bladder benign neoplasm 10.4 KRT7 PAX8
24 nephrogenic adenoma of urinary bladder 10.3 KRT7 PAX8
25 li-fraumeni syndrome 10.3 BRCA1 BRCA2 TP53
26 intracranial chondrosarcoma 10.3 CEACAM5 TP53
27 hereditary breast ovarian cancer syndrome 10.3 BRCA1 BRCA2 TP53
28 intracystic papillary adenoma 10.3 CEACAM5 ERBB2
29 gallbladder squamous cell carcinoma 10.3 CEACAM5 ERBB2
30 mucinous adenofibroma 10.3 CEACAM5 KRT7
31 anus adenocarcinoma 10.3 CEACAM5 KRT7
32 cutaneous mucoepidermoid carcinoma 10.3 CEACAM5 KRT7
33 anal gland adenocarcinoma 10.3 CEACAM5 KRT7
34 sweat gland cancer 10.3 ERBB2 KRT7 TP53
35 esophageal adenosquamous carcinoma 10.3 CDH1 CEACAM5
36 pancreatic ductal carcinoma 10.3 KRT7 TP53 VEGFA
37 hereditary site-specific ovarian cancer syndrome 10.3 BRCA1 BRCA2
38 dysgerminoma of ovary 10.3 BRCA1 BRCA2 WT1
39 laryngeal squamous cell carcinoma 10.3 CDH1 TP53 VEGFA
40 sigmoid neoplasm 10.3 CEACAM5 KRAS
41 oropharynx cancer 10.3 CDH1 KRT7 TP53
42 dysgerminoma 10.3 BRCA1 KRT7 WT1
43 tuberculous salpingitis 10.3 BRCA1 BRCA2 ERBB2
44 thymus cancer 10.3 KRT7 PAX8 TP53
45 urachal adenocarcinoma 10.3 CEACAM5 KRAS
46 grade iii astrocytoma 10.3 MMP2 TP53 VEGFA
47 barrett's adenocarcinoma 10.3 ERBB2 KRAS TP53
48 lung benign neoplasm 10.3 KRAS KRT7 TP53
49 nervous system cancer 10.3 AKT1 TP53 VEGFA
50 central nervous system cancer 10.3 AKT1 TP53 VEGFA

Graphical network of the top 20 diseases related to Ovary Epithelial Cancer:



Diseases related to Ovary Epithelial Cancer

Symptoms & Phenotypes for Ovary Epithelial Cancer

GenomeRNAi Phenotypes related to Ovary Epithelial Cancer according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.92 WT1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.92 ARID1A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.92 WT1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.92 BRCA1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.92 BRCA1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.92 WT1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.92 HNF1B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.92 PAX8
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.92 ARID1A BRCA1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.92 ARID1A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.92 HNF1B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.92 BRCA1 HNF1B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.92 ARID1A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.92 ARID1A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 HNF1B WT1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.92 WT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.92 PAX8
18 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.92 PAX8
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.92 WT1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.92 WT1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.92 PAX8
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.92 ARID1A BRCA1 HNF1B PAX8 WT1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.92 WT1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.92 HNF1B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.92 HNF1B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.92 BRCA1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.92 BRCA1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.92 ARID1A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.92 HNF1B
30 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.92 HNF1B
31 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.92 PAX8
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.92 WT1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.92 PAX8
34 Decreased viability in esophageal squamous lineage GR00235-A 9.77 ARID1A BRCA1 BRCA2 CDH1 ERBB2 HNF1B

MGI Mouse Phenotypes related to Ovary Epithelial Cancer:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.48 ACSBG1 AKT1 AREG ARID1A BRCA1 BRCA2
2 endocrine/exocrine gland MP:0005379 10.44 ACSBG1 AKT1 AREG ARID1A BRCA1 BRCA2
3 growth/size/body region MP:0005378 10.43 AKT1 AREG ARID1A BRCA1 BRCA2 CDH1
4 cardiovascular system MP:0005385 10.42 AKT1 AREG ARID1A BRCA1 CDH1 ERBB2
5 cellular MP:0005384 10.41 AKT1 ARID1A BRCA1 BRCA2 CDH1 ERBB2
6 embryo MP:0005380 10.39 AKT1 ARID1A BRCA1 BRCA2 CDH1 ERBB2
7 mortality/aging MP:0010768 10.37 AKT1 AREG ARID1A BRCA1 BRCA2 CDH1
8 immune system MP:0005387 10.35 AKT1 AREG ARID1A BRCA1 BRCA2 CDH1
9 neoplasm MP:0002006 10.23 AKT1 ARID1A BRCA1 BRCA2 CDH1 ERBB2
10 integument MP:0010771 10.22 AKT1 AREG BRCA1 BRCA2 CDH1 ERBB2
11 muscle MP:0005369 10.22 AKT1 ARID1A BRCA1 ERBB2 HNF1B KRAS
12 digestive/alimentary MP:0005381 10.19 AREG BRCA1 BRCA2 CDH1 ERBB2 KRAS
13 nervous system MP:0003631 10.17 AKT1 ARID1A BRCA1 BRCA2 ERBB2 KRAS
14 normal MP:0002873 10.15 AKT1 ARID1A BRCA1 BRCA2 CDH1 ERBB2
15 craniofacial MP:0005382 10.14 ARID1A ERBB2 KRAS MMP2 PAX8 TP53
16 reproductive system MP:0005389 10.1 ACSBG1 AKT1 AREG ARID1A BRCA1 BRCA2
17 no phenotypic analysis MP:0003012 10.06 ARID1A CDH1 ESS2 KRAS PAX8 PIK3CA
18 limbs/digits/tail MP:0005371 10.05 BRCA1 BRCA2 ERBB2 KRAS PAX8 TP53
19 renal/urinary system MP:0005367 9.92 BRCA1 HNF1B KRAS KRT7 PAX8 TP53
20 respiratory system MP:0005388 9.76 AKT1 BRCA1 ERBB2 KRAS MMP2 TP53
21 skeleton MP:0005390 9.7 AKT1 ARID1A BRCA1 BRCA2 ERBB2 KRAS
22 vision/eye MP:0005391 9.23 AREG ARID1A KRAS MMP2 PAX8 PIK3CA

Drugs & Therapeutics for Ovary Epithelial Cancer

Search Clinical Trials , NIH Clinical Center for Ovary Epithelial Cancer

Genetic Tests for Ovary Epithelial Cancer

Anatomical Context for Ovary Epithelial Cancer

MalaCards organs/tissues related to Ovary Epithelial Cancer:

41
Ovary, Liver, Prostate, Lung, Kidney, Pancreas, Thymus

Publications for Ovary Epithelial Cancer

Variations for Ovary Epithelial Cancer

Expression for Ovary Epithelial Cancer

Search GEO for disease gene expression data for Ovary Epithelial Cancer.

Pathways for Ovary Epithelial Cancer

Pathways related to Ovary Epithelial Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 AKT1 AREG BRCA1 BRCA2 ERBB2 KRAS
2
Show member pathways
13.54 AKT1 AREG BRCA1 CDH1 ERBB2 HNF1B
3
Show member pathways
13.53 AKT1 ERBB2 HNF1B KRAS KRT7 MMP2
4
Show member pathways
13.41 AKT1 ERBB2 KRAS MMP2 PIK3CA PSMA2
5
Show member pathways
13.33 AKT1 AREG CDH1 ERBB2 KRAS PSMA2
6
Show member pathways
13.06 AKT1 CDH1 KRAS PSMA2 TP53 VEGFA
7
Show member pathways
13.01 AKT1 AREG BRCA1 ERBB2 KRAS PIK3CA
8 12.8 AKT1 AREG ERBB2 KRAS TP53 VEGFA
9
Show member pathways
12.78 AKT1 CDH1 KRAS PIK3CA VEGFA
10
Show member pathways
12.76 AKT1 ERBB2 KRAS PIK3CA PSMA2 TP53
11
Show member pathways
12.75 AKT1 CDH1 ERBB2 KRAS PIK3CA TP53
12
Show member pathways
12.72 AKT1 KRAS MMP2 PIK3CA VEGFA
13
Show member pathways
12.72 AKT1 ARID1A BRCA1 BRCA2 CDH1 ERBB2
14
Show member pathways
12.62 AKT1 ERBB2 KRAS MMP2 PIK3CA TP53
15
Show member pathways
12.6 AKT1 AREG BRCA2 CDH1 ERBB2 KRAS
16
Show member pathways
12.56 AKT1 ERBB2 KRAS PIK3CA TP53
17 12.56 BRCA1 ERBB2 KRAS PIK3CA TP53 VEGFA
18
Show member pathways
12.52 AKT1 AREG CDH1 ERBB2 KRAS MMP2
19
Show member pathways
12.49 AKT1 ERBB2 KRAS PIK3CA TP53
20 12.48 AKT1 CDH1 HNF1B PSMA2 TP53
21
Show member pathways
12.47 AKT1 AREG ERBB2 KRAS PIK3CA TP53
22 12.46 AKT1 KRAS PIK3CA TP53
23
Show member pathways
12.44 AREG CDH1 ERBB2 KRAS PIK3CA
24
Show member pathways
12.44 AKT1 BRCA1 KRAS PIK3CA VEGFA
25 12.38 AKT1 BRCA2 CDH1 ERBB2 KRAS MMP2
26
Show member pathways
12.36 AKT1 ERBB2 KRAS PIK3CA
27
Show member pathways
12.3 AKT1 KRAS TP53 VEGFA
28
Show member pathways
12.3 AKT1 BRCA1 PSMA2 TP53
29 12.3 AKT1 ERBB2 KRAS MMP2 PIK3CA TP53
30
Show member pathways
12.28 AKT1 AREG KRAS VEGFA
31
Show member pathways
12.26 AKT1 ERBB2 KRAS PIK3CA TP53
32 12.23 AKT1 KRAS PIK3CA TP53
33
Show member pathways
12.22 AKT1 KRAS PIK3CA TP53
34 12.2 AKT1 CDH1 KRAS MMP2 TP53 VEGFA
35
Show member pathways
12.19 AKT1 ERBB2 KRAS PIK3CA
36
Show member pathways
12.19 AKT1 KRAS PIK3CA TP53
37
Show member pathways
12.17 AKT1 ERBB2 MMP2 PIK3CA
38 12.17 AKT1 ERBB2 KRAS PIK3CA TP53
39 12.13 AKT1 MMP2 PIK3CA TP53 VEGFA
40 12.12 AKT1 KRAS PIK3CA TP53
41 12.11 MMP2 PSMA2 TP53 VEGFA
42
Show member pathways
12.11 AKT1 AREG BRCA1 CDH1 KRAS PIK3CA
43 12.1 AKT1 BRCA1 BRCA2 CDH1 KRAS TP53
44
Show member pathways
12.09 AKT1 ERBB2 PIK3CA TP53
45 12.07 AKT1 KRAS PIK3CA TP53
46 12.05 AKT1 KRAS PIK3CA TP53
47
Show member pathways
12.03 AKT1 CDH1 HNF1B PSMA2 TP53
48 12.03 AKT1 MMP2 TP53 VEGFA
49 12.03 AKT1 ERBB2 KRAS PIK3CA TP53
50
Show member pathways
11.99 AKT1 BRCA1 BRCA2 CDH1 ERBB2 KRAS

GO Terms for Ovary Epithelial Cancer

Cellular components related to Ovary Epithelial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 AKT1 AREG ARID1A BRCA1 BRCA2 ERBB2
2 cytoplasm GO:0005737 9.5 ACSBG1 AKT1 AREG BRCA1 BRCA2 CDH1

Biological processes related to Ovary Epithelial Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.93 AKT1 AREG BRCA2 ERBB2 TP53
2 negative regulation of apoptotic process GO:0043066 9.87 AKT1 CEACAM5 ERBB2 HNF1B TP53 VEGFA
3 positive regulation of protein phosphorylation GO:0001934 9.86 AKT1 ERBB2 KRAS VEGFA
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 AREG TP53 VEGFA
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.8 AKT1 PIK3CA VEGFA
6 liver development GO:0001889 9.79 HNF1B KRAS PIK3CA
7 response to glucocorticoid GO:0051384 9.77 ACSBG1 AREG KRAS
8 positive regulation of MAP kinase activity GO:0043406 9.76 ERBB2 KRAS VEGFA
9 epidermal growth factor receptor signaling pathway GO:0007173 9.7 AKT1 AREG PIK3CA
10 kidney development GO:0001822 9.67 HNF1B PAX8 VEGFA WT1
11 cytokine-mediated signaling pathway GO:0019221 9.63 AKT1 KRAS MMP2 PIK3CA TP53 VEGFA
12 anoikis GO:0043276 9.61 AKT1 PIK3CA
13 cellular response to gonadotropin stimulus GO:0071371 9.59 PAX8 WT1
14 phosphatidylinositol 3-kinase signaling GO:0014065 9.58 AKT1 ERBB2 PIK3CA
15 mesonephric tubule development GO:0072164 9.57 HNF1B PAX8
16 positive regulation of gene expression GO:0010628 9.56 AKT1 BRCA1 ERBB2 HNF1B KRAS TP53
17 pronephros development GO:0048793 9.55 HNF1B PAX8
18 cellular response to indole-3-methanol GO:0071681 9.51 BRCA1 CDH1
19 metanephric epithelium development GO:0072207 9.49 PAX8 WT1
20 metanephric S-shaped body morphogenesis GO:0072284 9.48 PAX8 WT1
21 chordate embryonic development GO:0043009 9.46 BRCA1 BRCA2
22 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.43 HNF1B PAX8
23 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 BRCA1 BRCA2 TP53
24 positive regulation of transcription, DNA-templated GO:0045893 9.28 AKT1 ARID1A BRCA1 BRCA2 CDH1 HNF1B
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 AKT1 BRCA1 HNF1B PAX8 TP53 VEGFA
26 nervous system development GO:0007399 10.01 AKT1 ARID1A ERBB2 ESS2 VEGFA

Molecular functions related to Ovary Epithelial Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.35 BRCA1 HNF1B PAX8 TP53 WT1
2 identical protein binding GO:0042802 9.23 AKT1 BRCA1 BRCA2 CDH1 CEACAM5 ERBB2
3 protein binding GO:0005515 10.11 AKT1 AREG ARID1A BRCA1 BRCA2 CDH1

Sources for Ovary Epithelial Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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