Ovary Leiomyosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ovary Leiomyosarcoma

MalaCards integrated aliases for Ovary Leiomyosarcoma:

Name: Ovary Leiomyosarcoma ¹² ¹⁵

Leiomyosarcoma of Ovary ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5263

NCIt ⁴⁹ C5234

UMLS ⁷¹ C1335163

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Summaries for Ovary Leiomyosarcoma

Disease Ontology : ¹² An ovary sarcoma that arises from smooth muscle progenitors.

MalaCards based summary : Ovary Leiomyosarcoma, also known as leiomyosarcoma of ovary, is related to leiomyosarcoma and leiomyoma. An important gene associated with Ovary Leiomyosarcoma is SUFU (SUFU Negative Regulator Of Hedgehog Signaling), and among its related pathways/superpathways are Signaling by Hedgehog and Translation Non-genomic (rapid) action of Androgen Receptor. The drugs Gemcitabine and Trabectedin have been mentioned in the context of this disorder. Affiliated tissues include ovary and smooth muscle.

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Related Diseases for Ovary Leiomyosarcoma

Diseases related to Ovary Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyosarcoma	10.2
2	leiomyoma	9.9
3	cystadenocarcinoma	9.9
4	myxoid leiomyosarcoma	9.9
5	melanotic medulloblastoma	9.9	SUFU PTCH1
6	nodular medulloblastoma	9.9	SUFU PTCH1
7	adult medulloblastoma	9.8	SUFU PTCH1
8	keratocystic odontogenic tumor	9.8	SUFU PTCH1
9	microform holoprosencephaly	9.8	SUFU PTCH1
10	holoprosencephaly	9.8	SUFU PTCH1
11	focal dermal hypoplasia	9.8	SUFU PTCH1
12	greig cephalopolysyndactyly syndrome	9.8	SUFU PTCH1
13	childhood medulloblastoma	9.8	SUFU PTCH1
14	basal cell nevus syndrome	9.8	SUFU PTCH1
15	infratentorial cancer	9.8	SUFU PTCH1
16	craniopharyngioma	9.7	SUFU PTCH1
17	ellis-van creveld syndrome	9.7	SUFU PTCH1
18	li-fraumeni syndrome	9.7	SUFU PTCH1
19	central nervous system cancer	9.7	SUFU PTCH1
20	skin carcinoma	9.6	SUFU PTCH1
21	meningioma, familial	9.5	SUFU PTCH1
22	basal cell carcinoma	9.4	SUFU PTCH1

Graphical network of the top 20 diseases related to Ovary Leiomyosarcoma:

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Symptoms & Phenotypes for Ovary Leiomyosarcoma

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Drugs & Therapeutics for Ovary Leiomyosarcoma

Drugs for Ovary Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Gemcitabine

Approved

Phase 2

95058-81-4

60750

Synonyms:

103882-84-4

122111-03-9

2',2'-DFDC

2',2'-DiF-dC

2',2'-difluoro-2'-Deoxycytidine

2',2'-Difluoro-2'-deoxycytidine

2',2'-Difluorodeoxycytidine

2'-Deoxy-.beta.-D-2',2'-difluorocytidine

2'-Deoxy-2',2'-difluorocytidine

2'-Deoxy-2',2''-difluorocytidine-5'-O-monophosphate

2'-Deoxy-2'-difluorocytidine

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-Hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one

95058-81-4

AB1004842

AC1L1TUQ

C07650

CCRIS 8984

CHEBI:175901

CHEMBL888

CID60750

Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine

D02368

DB00441

DDFC

DFdC

DFDC

DFdCyd

Folfugem

Gamcitabine

Gemcel

Gemcin

Gemcitabin

Gemcitabina

Gemcitabina [INN-Spanish]

gemcitabine

Gemcitabine

Gemcitabine (USAN/INN)

Gemcitabine HCl

Gemcitabine hydrochloride

Gemcitabine stereoisomer

Gemcitabine, (alpha-D-threo-pentofuranosyl)-isomer

Gemcitabine, (beta-D-threo-pentafuranosyl)-isomer

Gemcitabine, (D-threo-pentafuranosyl)-isomer

Gemcitabinum

Gemcitabinum [INN-Latin]

GemLip

Gemtro

Gemzar

Gemzar (hydrochloride)

GEO

HMS2089P10

HSDB 7567

Inno-D07001

LS-59139

LY 188011

LY188011

LY-188011

NCGC00168784-01

NChemBio.2007.10-comp25

nchembio.573-comp7

nchembio.90-comp2

NSC 613327

NSC613327

TL8005979

UNII-B76N6SBZ8R

Zefei

ZINC18279854

2

Trabectedin

Approved, Investigational

Phase 2

114899-77-3

108150

3

Anti-Infective Agents

Phase 2

4

Immunologic Factors

Phase 2

5

Antiviral Agents

Phase 2

6

Alkylating Agents

Phase 2

7

Immunosuppressive Agents

Phase 2

8

Antimetabolites

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Phase II Trial Comparing the Activity of trabectedIn vs Gemcitabine in Patients With Metastatic or Locally Advanced Leiomyosarcoma Pretreated With Conventional Chemotherapy	Not yet recruiting	NCT04383119	Phase 2	Trabectedin;Gemcitabine

Search NIH Clinical Center for Ovary Leiomyosarcoma

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Genetic Tests for Ovary Leiomyosarcoma

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Anatomical Context for Ovary Leiomyosarcoma

MalaCards organs/tissues related to Ovary Leiomyosarcoma:

⁴⁰

Ovary, Smooth Muscle

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Publications for Ovary Leiomyosarcoma

Articles related to Ovary Leiomyosarcoma:

#	Title	Authors	PMID	Year
1	Prolonged Survival of a Young Female with High Grade Pleomorphic Leiomyosarcoma of Ovary Without Recurrence. ⁶¹	Nazneen S...Pankaj S	27803531	2016
2	A rare presentation of primary leiomyosarcoma of ovary in a young woman. ⁶¹	Vijaya Kumar J...Singh S	25932048	2015
3	Myxoid leiomyosarcoma of ovary-a rare case report. ⁶¹	Ns D...V S	25120990	2014
4	Leiomyosarcoma of ovary--a case report. ⁶¹	Kurian RR...Remadevi AV	16758777	2005
5	Leiomyosarcoma of the ovary. ⁶¹	Dixit S...Sooryanaraya U	8051647	1993

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Genes for Ovary Leiomyosarcoma

Genes related to Ovary Leiomyosarcoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	6.58	DISEASES inferred ¹⁵
2	PGK1	Phosphoglycerate Kinase 1	Protein Coding	4.95	DISEASES inferred ¹⁵
3	PTCH1	Patched 1	Protein Coding	4.48	DISEASES inferred ¹⁵

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Variations for Ovary Leiomyosarcoma

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Expression for Ovary Leiomyosarcoma

Search GEO for disease gene expression data for Ovary Leiomyosarcoma.

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Pathways for Ovary Leiomyosarcoma

Pathways related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by Hedgehog ⁶⁵ Show member pathways Activation of SMO ⁶⁵ Hedgehog off' state ⁶⁵ Hedgehog on' state ⁶⁵	11.91	SUFU PTCH1
2	Translation Non-genomic (rapid) action of Androgen Receptor ²² Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²²	11.64	SUFU PTCH1
3	Wnt / Hedgehog / Notch ⁴	11.52	SUFU PTCH1
4	Hedgehog signaling pathway (KEGG) ³⁶	10.85	SUFU PTCH1
5	Hedgehog signaling events mediated by Gli proteins ¹	10.6	SUFU PTCH1
6	Hedgehog Signaling Pathway (WikiPathways) ¹ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁵	9.9	SUFU PTCH1

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GO Terms for Ovary Leiomyosarcoma

Cellular components related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cilium	GO:0005929	8.62	SUFU PTCH1

Biological processes related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neural tube closure	GO:0001843	9.32	SUFU PTCH1
2	negative regulation of DNA-binding transcription factor activity	GO:0043433	9.26	SUFU PTCH1
3	smoothened signaling pathway	GO:0007224	9.16	SUFU PTCH1
4	negative regulation of osteoblast differentiation	GO:0045668	8.96	SUFU PTCH1
5	negative regulation of smoothened signaling pathway	GO:0045879	8.62	SUFU PTCH1

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Sources for Ovary Leiomyosarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia