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MCID: OVR035
MIFTS: 20

Ovary Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Ovary Leiomyosarcoma

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MalaCards integrated aliases for Ovary Leiomyosarcoma:

Name: Ovary Leiomyosarcoma 12 15
Leiomyosarcoma of Ovary 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5263
NCIt 49 C5234
UMLS 71 C1335163
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Summaries for Ovary Leiomyosarcoma

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Disease Ontology : 12 An ovary sarcoma that arises from smooth muscle progenitors.

MalaCards based summary : Ovary Leiomyosarcoma, also known as leiomyosarcoma of ovary, is related to leiomyosarcoma and cystadenocarcinoma. An important gene associated with Ovary Leiomyosarcoma is SUFU (SUFU Negative Regulator Of Hedgehog Signaling), and among its related pathways/superpathways are Signaling by Hedgehog and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Affiliated tissues include ovary, smooth muscle and skin.

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Related Diseases for Ovary Leiomyosarcoma

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Diseases related to Ovary Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.2
2 cystadenocarcinoma 9.9
3 myxoid leiomyosarcoma 9.9
4 melanotic medulloblastoma 9.9 SUFU PTCH1
5 nodular medulloblastoma 9.9 SUFU PTCH1
6 adult medulloblastoma 9.9 SUFU PTCH1
7 keratocystic odontogenic tumor 9.9 SUFU PTCH1
8 microform holoprosencephaly 9.8 SUFU PTCH1
9 holoprosencephaly 9.8 SUFU PTCH1
10 focal dermal hypoplasia 9.8 SUFU PTCH1
11 greig cephalopolysyndactyly syndrome 9.8 SUFU PTCH1
12 childhood medulloblastoma 9.8 SUFU PTCH1
13 basal cell nevus syndrome 9.8 SUFU PTCH1
14 infratentorial cancer 9.8 SUFU PTCH1
15 craniopharyngioma 9.8 SUFU PTCH1
16 ellis-van creveld syndrome 9.7 SUFU PTCH1
17 li-fraumeni syndrome 9.7 SUFU PTCH1
18 central nervous system cancer 9.7 SUFU PTCH1
19 meningioma, familial 9.6 SUFU PTCH1
20 skin carcinoma 9.5 SUFU PTCH1
21 basal cell carcinoma 9.4 SUFU PTCH1

Graphical network of the top 20 diseases related to Ovary Leiomyosarcoma:



Diseases related to Ovary Leiomyosarcoma
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Symptoms & Phenotypes for Ovary Leiomyosarcoma

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Drugs & Therapeutics for Ovary Leiomyosarcoma

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Search Clinical Trials , NIH Clinical Center for Ovary Leiomyosarcoma

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Genetic Tests for Ovary Leiomyosarcoma

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Anatomical Context for Ovary Leiomyosarcoma

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MalaCards organs/tissues related to Ovary Leiomyosarcoma:

40
Ovary, Smooth Muscle, Skin
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Publications for Ovary Leiomyosarcoma

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Articles related to Ovary Leiomyosarcoma:

# Title Authors PMID Year
1
Prolonged Survival of a Young Female with High Grade Pleomorphic Leiomyosarcoma of Ovary Without Recurrence. 61
27803531 2016
2
A rare presentation of primary leiomyosarcoma of ovary in a young woman. 61
25932048 2015
3
Myxoid leiomyosarcoma of ovary-a rare case report. 61
25120990 2014
4
Leiomyosarcoma of ovary--a case report. 61
16758777 2005
5
Leiomyosarcoma of the ovary. 61
8051647 1993
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Variations for Ovary Leiomyosarcoma

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Expression for Ovary Leiomyosarcoma

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Search GEO for disease gene expression data for Ovary Leiomyosarcoma.
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Pathways for Ovary Leiomyosarcoma

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Pathways related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by Hedgehog 65
Show member pathways
 11.91 SUFU PTCH1
2
Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling 64
Show member pathways
 11.81 SUFU PTCH1
3
Wnt / Hedgehog / Notch 4
11.52 SUFU PTCH1
4
Hedgehog signaling pathway (KEGG) 36
10.85 SUFU PTCH1
5
Hedgehog signaling events mediated by Gli proteins 1
10.6 SUFU PTCH1
6
Hedgehog Signaling Pathway (WikiPathways) 1
Show member pathways
 9.9 SUFU PTCH1
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GO Terms for Ovary Leiomyosarcoma

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Cellular components related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 8.62 SUFU PTCH1

Biological processes related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neural tube closure GO:0001843 9.26 SUFU PTCH1
2 negative regulation of DNA-binding transcription factor activity GO:0043433 9.16 SUFU PTCH1
3 negative regulation of osteoblast differentiation GO:0045668 8.96 SUFU PTCH1
4 negative regulation of smoothened signaling pathway GO:0045879 8.62 SUFU PTCH1
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Sources for Ovary Leiomyosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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