MCID: OVR035
MIFTS: 23

Ovary Leiomyosarcoma

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Ovary Leiomyosarcoma

MalaCards integrated aliases for Ovary Leiomyosarcoma:

Name: Ovary Leiomyosarcoma 12 15
Leiomyosarcoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5263
NCIt 49 C5234
UMLS 71 C1335163

Summaries for Ovary Leiomyosarcoma

Disease Ontology : 12 An ovary sarcoma that arises from smooth muscle progenitors.

MalaCards based summary : Ovary Leiomyosarcoma, also known as leiomyosarcoma of ovary, is related to leiomyosarcoma and leiomyoma. An important gene associated with Ovary Leiomyosarcoma is SUFU (SUFU Negative Regulator Of Hedgehog Signaling), and among its related pathways/superpathways are Signaling by Hedgehog and Translation Non-genomic (rapid) action of Androgen Receptor. The drugs Gemcitabine and Trabectedin have been mentioned in the context of this disorder. Affiliated tissues include ovary and smooth muscle.

Related Diseases for Ovary Leiomyosarcoma

Graphical network of the top 20 diseases related to Ovary Leiomyosarcoma:



Diseases related to Ovary Leiomyosarcoma

Symptoms & Phenotypes for Ovary Leiomyosarcoma

Drugs & Therapeutics for Ovary Leiomyosarcoma

Drugs for Ovary Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2 95058-81-4 60750
2
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
3 Anti-Infective Agents Phase 2
4 Immunologic Factors Phase 2
5 Antiviral Agents Phase 2
6 Alkylating Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Trial Comparing the Activity of trabectedIn vs Gemcitabine in Patients With Metastatic or Locally Advanced Leiomyosarcoma Pretreated With Conventional Chemotherapy Not yet recruiting NCT04383119 Phase 2 Trabectedin;Gemcitabine

Search NIH Clinical Center for Ovary Leiomyosarcoma

Genetic Tests for Ovary Leiomyosarcoma

Anatomical Context for Ovary Leiomyosarcoma

MalaCards organs/tissues related to Ovary Leiomyosarcoma:

40
Ovary, Smooth Muscle

Publications for Ovary Leiomyosarcoma

Articles related to Ovary Leiomyosarcoma:

# Title Authors PMID Year
1
Prolonged Survival of a Young Female with High Grade Pleomorphic Leiomyosarcoma of Ovary Without Recurrence. 61
27803531 2016
2
A rare presentation of primary leiomyosarcoma of ovary in a young woman. 61
25932048 2015
3
Myxoid leiomyosarcoma of ovary-a rare case report. 61
25120990 2014
4
Leiomyosarcoma of ovary--a case report. 61
16758777 2005
5
Leiomyosarcoma of the ovary. 61
8051647 1993

Variations for Ovary Leiomyosarcoma

Expression for Ovary Leiomyosarcoma

Search GEO for disease gene expression data for Ovary Leiomyosarcoma.

Pathways for Ovary Leiomyosarcoma

Pathways related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 SUFU PTCH1
2
Show member pathways
11.64 SUFU PTCH1
3 11.52 SUFU PTCH1
4 10.85 SUFU PTCH1
5 10.6 SUFU PTCH1
6
Show member pathways
9.9 SUFU PTCH1

GO Terms for Ovary Leiomyosarcoma

Cellular components related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 8.62 SUFU PTCH1

Biological processes related to Ovary Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neural tube closure GO:0001843 9.32 SUFU PTCH1
2 negative regulation of DNA-binding transcription factor activity GO:0043433 9.26 SUFU PTCH1
3 smoothened signaling pathway GO:0007224 9.16 SUFU PTCH1
4 negative regulation of osteoblast differentiation GO:0045668 8.96 SUFU PTCH1
5 negative regulation of smoothened signaling pathway GO:0045879 8.62 SUFU PTCH1

Sources for Ovary Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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