Ovary Serous Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OVR062 MIFTS: 29	Ovary Serous Adenocarcinoma Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Ovary Serous Adenocarcinoma

MalaCards integrated aliases for Ovary Serous Adenocarcinoma:

Name: Ovary Serous Adenocarcinoma ¹² ¹⁵

Malignant Ovarian Serous Tumor ¹² ⁷⁴

Serous Carcinoma of Ovary ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5744

NCIt ⁵¹ C40025 C7550

UMLS ⁷⁴ C1335177 C1518234

Sources

Summaries for Ovary Serous Adenocarcinoma

Disease Ontology : ¹² An ovary adenocarcinoma that derives from the lining of a cavity that produces a serum-like fluid (a serous cavity).

MalaCards based summary : Ovary Serous Adenocarcinoma, also known as malignant ovarian serous tumor, is related to ovarian serous cystadenocarcinoma and endometrial stromal nodule. An important gene associated with Ovary Serous Adenocarcinoma is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways is Tyrosine Kinases / Adaptors. The drugs Paclitaxel and Iodine have been mentioned in the context of this disorder. Affiliated tissues include ovary, t cells and lymph node, and related phenotype is Decreased substrate adherent cell growth.

Sources

Related Diseases for Ovary Serous Adenocarcinoma

Diseases related to Ovary Serous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	ovarian serous cystadenocarcinoma	11.3
2	endometrial stromal nodule	9.9
3	choriocarcinoma	9.9
4	carcinosarcoma	9.9

Sources

Symptoms & Phenotypes for Ovary Serous Adenocarcinoma

GenomeRNAi Phenotypes related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased substrate adherent cell growth	GR00193-A-2	8.62	EPHA1 EPHB1

Sources

Drugs & Therapeutics for Ovary Serous Adenocarcinoma

Drugs for Ovary Serous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Paclitaxel

Approved, Vet_approved

Phase 2

33069-62-4

36314

Synonyms:

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

157069-30-2

33069-62-4

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

7 Epi taxol

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.

7-epi-Paclitaxel

7-Epipaclitaxel

7-Epi-paclitaxel

7-epi-Taxol

7-Epitaxol

7-Epi-taxol

AB00513812

ABI 007

abi-007

ABI007

ABI-007

Abraxane

Abraxane (TN)

Abraxane I.V. Suspension

Abraxis BioScience brand of albumin-bound paclitaxel

AC1L1IOG

AC1L1VJI

AC1L9AVF

AC-675

ACon1_002231

albumin-bound paclitaxel

Ambotz33069-62-4

ANX-513

Anzatax

Asotax

BIDD:PXR0046

Bio-0076

Bio1_000362

Bio1_000851

Bio1_001340

Bio2_000416

Bio2_000896

BMS 181339-01

BMS-181339

BMS-181339-01

BPBio1_000320

BRD-A23723433-001-01-2

BRD-A28746609-001-04-0

BRD-K62008436-001-03-1

Bris taxol

Bristaxol

BSPBio_000290

BSPBio_001152

BSPBio_002614

C07394

C466458

C47H51NO14

Capxol

CCRIS 8143

CHEBI:103439

CHEBI:45863

CHEMBL100910

CHEMBL418410

CHEMBL48

CID36314

CID441276

CID4666

CID6713921

CID6915727

cMAP_000068

CPD-8718

D00491

DB01229

DHP-107

DHP-208

DivK1c_000441

DRG-0190

DTS-301

Ebetaxel

EmPAC

Epitaxol

EU-0101201

Genaxol

Genetaxyl

Genexol

Genexol-PM

HMS1362J13

HMS1568O12

HMS1792J13

HMS1922K08

HMS1990J13

HMS2090D07

HMS2093K15

HMS501G03

HSDB 6839

I06-0014

IDI1_000441

IDI1_002171

Intaxel

KBio1_000441

KBio2_000492

KBio2_002016

KBio2_002509

KBio2_003060

KBio2_004584

KBio2_005077

KBio2_005628

KBio2_007152

KBio2_007645

KBio3_000903

KBio3_000904

KBio3_001834

KBio3_002987

KBioGR_000492

KBioGR_001893

KBioGR_002509

KBioSS_000492

KBioSS_002016

KBioSS_002517

LipoPac

LMPR0104390001

Lopac0_001201

LS-31070

MBT 0206

MEGxp0_001940

Micellar Paclitaxel

Mitotax

MLS000863266

MLS001077297

MLS002154218

MLS002172439

MLS002695976

MolPort-001-742-627

MolPort-003-665-783

MolPort-003-932-365

MPI-5018

nab-paclitaxel

Nanotaxel

NCGC00024995-02

NCGC00024995-03

NCGC00024995-04

NCGC00024995-05

NCGC00024995-06

NCGC00024995-07

NCGC00164367-01

NCGC00164367-02

NCGC00164367-03

nchembio.188-comp1

nchembio.2007.34-comp9

nchembio.215-comp9

nchembio853-comp6

NCI60_000601

Neuro_000060

NINDS_000441

NK 105

Nova-12005

NP-010981

NSC 125973

NSC125973

NSC-125973

NSC358882

OAS-PAC-100

OncoGel

Onxal

Onxol

Onxol, Taxol, Nov-Onxol, Paclitaxel

P1632

Paclical

Pacligel

paclitaxel

Paclitaxel

Paclitaxel (JAN/USP)

Paclitaxel (JAN/USP/INN)

Paclitaxel (Taxol)

Paclitaxel [USAN:INN:BAN]

Paclitaxel, (4 alpha)-isomer

Paxceed

Paxene

Paxoral

Plaxicel

Praxel

Prestwick0_000155

Prestwick1_000155

Prestwick2_000155

Prestwick3_000155

Probes2_000350

QW 8184

S1150_Selleck

S-8184 Paclitaxel Injectable Emulsion

SDCCGMLS-0066823.P001

SDP-013

SMP1_000228

SMR000394086

SMR000857385

SPBio_000943

SPBio_002229

Spectrum_001536

SPECTRUM1503908

Spectrum2_000872

Spectrum3_001057

Spectrum4_001197

Spectrum5_001491

ST50306996

T 7402

T1912_SIGMA

T7191_SIGMA

T7402_SIGMA

TA1

TaxAlbin

Taxol

TAXOL

TAXOL (TN)

Taxol a

Taxol A

Taxol Konzentrat

TAXOL, 10-EPI,

Taxol, bris

Taxol.RTM. (Registered Trademark)

TXL

UNII-P88XT4IS4D

UPCMLD-DP108:001

UPCMLD-DP108:002

Vascular Wrap

weekly paclitaxel

Xorane

Yewtaxan

Iodine

Approved, Investigational

Phase 2

7553-56-2

807

Synonyms:

diiodine

Iode

Iodine-molecule

Iodio

iodo

Iodum

Jod

Jood

molecular iodine

Molecular iodine

Tincture iodine

Doxorubicin

Approved, Investigational

Phase 2

23214-92-8

31703

Synonyms:

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-a-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

111266-55-8

14-hydroxydaunomycin

14-Hydroxydaunomycin

14-hydroxydaunorubicine

14-Hydroxydaunorubicine

23214-92-8

23257-17-2

24385-08-8

25311-50-6

25316-40-9

25316-40-9 (hydrochloride)

29042-30-6

AC1L1M5T

AC1Q29OJ

adiblastine (hydrochloride salt)

ADM

ADR

adr iablatina (hydrochloride salt)

Adriablastin

Adriablastine

adriablastine (hydrochloride salt)

adriablatina (hydrochloride salt)

Adriacin (hydrochloride salt)

Adriamycin

Adriamycin PFS

Adriamycin PFS (hydrochloride salt)

Adriamycin RDF

Adriamycin RDF (hydrochloride salt)

Adriamycin semiquinone

Adriamycin Semiquinone

Adriblas tina

Adriblastin

Adriblastina

Adriblastina (hydrochloride salt)

Adriblastina (TN)

Adriblastine

adriblatina (hydrochloride salt)

Adrimedac

Aerosolized Doxorubicin

Baxter brand OF doxorubicin hydrochloride

Bedford brand OF doxorubicin hydrochloride

BPBio1_000502

BRD-K92093830-003-04-3

Bristol-myers squibb brand OF doxorubicin hydrochloride

BSPBio_000456

BSPBio_001031

C01661

C27H29NO11

Caelyx

CCRIS 739

Cell pharm brand OF doxorubicin hydrochloride

CHEBI:28748

CHEMBL179

CID31703

Columbia brand OF doxorubicin hydrochloride

Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74

Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120

D03899

DB00997

DM2

Doxil

Doxo

doxo Cell

doxo-Cell

Doxolem

doxorubicin

Doxorubicin

Doxorubicin (USAN/INN)

Doxorubicin [USAN:INN:BAN]

Doxorubicin citrate

Doxorubicin HCl

Doxorubicin hexal

Doxorubicin hydrochloride

Doxorubicin Hydrochloride

Doxorubicin hydrochloride (hydrochloride salt)

Doxorubicin NC

Doxorubicina

Doxorubicina [INN-Spanish]

Doxorubicina ferrer farm

Doxorubicina funk

Doxorubicina tedec

Doxorubicine

Doxorubicine [INN-French]

Doxorubicine baxter

Doxorubicin-hLL1

Doxorubicin-hLL1 conjugate

Doxorubicin-P4/D10

Doxorubicin-P4/D10 conjugate

Doxorubicinum

Doxorubicinum [INN-Latin]

Doxotec

DOX-SL

EINECS 245-495-6

Elan brand OF doxorubicin hydrochloride

Farmablastina (hydrochloride salt)

Farmiblastina

Ferrer brand OF doxorubicin hydrochloride

FI 106

Hexal brand OF doxorubicin hydrochloride

HMS2089H06

HSDB 3070

Hydrochloride, doxorubicin

Hydroxydaunomycin hydrochlor ide (hydrochloride salt)

Hydroxydaunomycin hydrochloride (hydrochloride salt)

Hydroxydaunorubicin

Hydroxydaunorubicin hydrochloride (hydrochloride salt)

JT9100000

Kenfarma brand OF doxorubicin hydrochloride

Lemery brand OF doxorubicin hydrochloride

LMPK13050001

LS-1029

LS-165655

Medac brand OF doxorubicin hydrochloride

MLS000759533

Myocet

NChemBio.2007.10-comp13

nchembio809-comp5

NCI-C01514

NDC 38242-874

Neocorp brand OF doxorubicin hydrochloride

NIOSH/JT9100000

NSC 123127

Onkodox

Onkoworks brand OF doxorubicin hydrochloride

Pfizer brand OF doxorubicin hydrochloride

Prasfarma brand OF doxorubicin hydrochloride

Prestwick0_000438

Prestwick1_000438

Prestwick2_000438

Prestwick3_000438

Probes1_000151

Probes2_000129

RDF Rubex

Resmycin

Ribodoxo

Ribosepharm brand OF doxorubicin hydrochloride

Rubex

Rubex (hydrochloride salt)

SMP1_000106

SPBio_002395

Tedec meiji brand OF doxorubicin hydrochloride

ThermoDox

TLC D-99

Triferric doxorubicin

UNII-80168379AG

Urokit doxo cell

Urokit doxo-cell

Gemcitabine

Approved

Phase 2

95058-81-4

60750

Synonyms:

103882-84-4

122111-03-9

2',2'-DFDC

2',2'-DiF-dC

2',2'-difluoro-2'-Deoxycytidine

2',2'-Difluoro-2'-deoxycytidine

2',2'-Difluorodeoxycytidine

2'-Deoxy-.beta.-D-2',2'-difluorocytidine

2'-Deoxy-2',2'-difluorocytidine

2'-Deoxy-2',2''-difluorocytidine-5'-O-monophosphate

2'-Deoxy-2'-difluorocytidine

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-Hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one

95058-81-4

AB1004842

AC1L1TUQ

C07650

CCRIS 8984

CHEBI:175901

CHEMBL888

CID60750

Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine

D02368

DB00441

DDFC

DFdC

DFDC

DFdCyd

Folfugem

Gamcitabine

Gemcel

Gemcin

Gemcitabin

Gemcitabina

Gemcitabina [INN-Spanish]

gemcitabine

Gemcitabine

Gemcitabine (USAN/INN)

Gemcitabine HCl

Gemcitabine hydrochloride

Gemcitabine stereoisomer

Gemcitabine, (alpha-D-threo-pentofuranosyl)-isomer

Gemcitabine, (beta-D-threo-pentafuranosyl)-isomer

Gemcitabine, (D-threo-pentafuranosyl)-isomer

Gemcitabinum

Gemcitabinum [INN-Latin]

GemLip

Gemtro

Gemzar

Gemzar (hydrochloride)

GEO

HMS2089P10

HSDB 7567

Inno-D07001

LS-59139

LY 188011

LY188011

LY-188011

NCGC00168784-01

NChemBio.2007.10-comp25

nchembio.573-comp7

nchembio.90-comp2

NSC 613327

NSC613327

TL8005979

UNII-B76N6SBZ8R

Zefei

ZINC18279854

Topotecan

Approved, Investigational

Phase 2

123948-87-8, 119413-54-6

60700

Synonyms:

(4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione

(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE

123948-87-8

9 Dimethylaminomethyl 10 hydroxycamptothecin

9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin

9-[(dimethylamino)Methyl]-10-hydroxy-(4S)-camptothecin

9-Dimethylaminomethyl-10-hydroxycamptothecin

AC-11592

AC1L1TQZ

AC1Q6APZ

BSPBio_002348

C11158

C23H23N3O5

CCRIS 8163

CHEBI:107501

CHEBI:46035

CHEMBL84

CID60700

D08618

DB01030

HMS2090B20

HSCI1_000228

Hycamptamine

Hycamptin

Hycamtamine

Hycamtin

Hycamtin (TN)

Hydrochloride, nogitecan

Hydrochloride, topotecan

LS-127395

MLS000759456

NCGC00178695-01

NChemBio.2007.10-comp24

NCI60_004771

NCIStruc1_001659

NCIStruc2_001796

Nogitecan hydrochloride

NSC609699

SK And F 104864 a

SK And F104864a

SK And F-104864-a

SK&F-104864-A

SKF 104864

SKF-104864-A

SKF-S 104864

SmithKline beecham brand OF topotecan hydrochloride

SMP2_000312

SMP2_000327

SMR000466344

TOPO

topotecan

Topotecan

Topotecan (BAN)

Topotecan [INN:BAN]

Topotecan Hcl

Topotecan hydrochloride

Topotecan Hydrochloride

Topotecan lactone

Topotecan Lactone

Topotecan monohydrochloride, (S)-isomer

Topotecan Monohydrochloride, (S)-Isomer

TOPOTECAN, HYCAMTIN

Topotecane

Topotecane [INN-French]

Topotecanum

Topotecanum [INN-Latin]

TPT

TTC

UNII-7M7YKX2N15

Acetylcysteine

Approved, Investigational

Phase 2

616-91-1

12035

Synonyms:

(2R)-2-acetylamino-3-Sulfanylpropanoate

(2R)-2-acetylamino-3-sulfanylpropanoic acid

(2R)-2-acetylamino-3-Sulfanylpropanoic acid

(2R)-2-acetylamino-3-Sulphanylpropanoate

(2R)-2-acetylamino-3-Sulphanylpropanoic acid

(R)-2-acetylamino-3-Mercaptopropanoate

(R)-2-acetylamino-3-mercaptopropanoic acid

(R)-2-acetylamino-3-Mercaptopropanoic acid

(R)-Mercaptate

(R)-Mercaptic acid

(R)-mercapturic acid

(R)-Mercapturic acid

2-acetylamino-3-mercapto-Propionate

2-acetylamino-3-mercapto-Propionic acid

Ac pharma brand OF acetylcysteine

ACC

Acebraus

Acemuc

Acetabs

Acetadote

Acetilcisteina

Acetylcystein al

Acetylcystein atid

Acetylcystein heumann

Acetylcystein trom

Acetylcystein, mentopin

Acetylcysteine

Acetylcysteine ac-pharma brand

Acetylcysteine alcon brand

Acetylcysteine aluid brand

Acetylcysteine atid brand

Acetylcysteine azupharma brand

Acetylcysteine betapharm brand

Acetylcysteine bioiberica brand

Acetylcysteine bouchara brand

Acetylcysteine centrafarm brand

Acetylcysteine disphar brand

Acetylcysteine farmasan brand

Acetylcysteine fresenius brand

Acetylcysteine génévrier brand

Acétylcystéine GNR

Acetylcysteine GNR-pharma brand

Acetylcysteine guerbet brand

Acetylcysteine hermes brand

Acetylcysteine heumann brand

Acetylcysteine hydrochloride

Acetylcysteine inpharzam brand

Acetylcysteine intra brand

Acetylcysteine klinge brand

Acetylcysteine krewel brand

Acetylcysteine lichtenstein brand

Acetylcysteine lindopharm brand

Acetylcysteine merck brand

Acetylcysteine oberlin brand

Acetylcysteine pfleger brand

Acetylcysteine pharbita brand

Acetylcysteine roberts brand

Acetylcysteine sodium

Acetylcysteine temmler brand

Acetylcysteine teva brand

Acetylcysteine thiemann brand

Acetylcysteine trommsdorff brand

Acetylcysteine upsa brand

Acetylcysteine whitehall brand

Acetylcysteine zambon brand

Acetylcysteine zinc

Acetylcysteine zyma brand

Acetylcysteine, (D)-isomer

Acetylcysteine, (DL)-isomer

Acetylcysteine, monoammonium salt

Acetylcysteine, monosodium salt

Acetylcysteinum

Acetylin

Acetyst

Acid, mercapturic

Ac-pharma brand OF acetylcysteine

Airbron

Alcon brand OF acetylcysteine

Allen and hanburys brand OF acetylcysteine

Aluid brand OF acetylcysteine

Alveolex

Atid brand OF acetylcysteine

Azubronchin

Azupharma brand OF acetylcysteine

Betapharm brand OF acetylcysteine

Bioiberica brand OF acetylcysteine

Bisolvon nac

Boehringer ingelheim brand OF acetylcysteine

Bouchara brand OF acetylcysteine

Bristol myers squibb brand OF acetylcysteine

Bristol myers squibb brand OF acetylcysteine sodium salt

Bristol-myers squibb brand OF acetylcysteine

Bristol-myers squibb brand OF acetylcysteine sodium salt

Bromuc

broncho Fips

broncho-Fips

BronchoFips

Broncholysin

Broncoclar

Centrafarm brand OF acetylcysteine

Codotussyl

Cystamucil

dampo Mucopect

Dey brand OF acetylcysteine sodium salt

Disphar brand OF acetylcysteine

Durabronchal

Eurespiran

Exomuc

Fabrol

Farmasan brand OF acetylcysteine

Fluimicil infantil

Fluimucetin

Fluimucil

Flumucetin

Fluprowit

Frekatuss

Fresenius brand OF acetylcysteine

Genac

Génévrier brand OF acetylcysteine

GNR Pharma brand OF acetylcysteine

GNR-Pharma brand OF acetylcysteine

Guerbet brand OF acetylcysteine

Hermes brand OF acetylcysteine

Heumann brand OF acetylcysteine

Hoestil

Hustengetränk, optipect

Hydrochloride, acetylcysteine

Ilube

Inpharzam brand OF acetylcysteine

Intra brand OF acetylcysteine

Jenacystein

Jenapharm

Klinge brand OF acetylcysteine

Krewel brand OF acetylcysteine

L-a-acetamido-b-Mercaptopropionate

L-a-acetamido-b-Mercaptopropionic acid

L-acetylcysteine

L-Acetylcysteine

L-alpha-acetamido-beta-Mercaptopropionate

L-alpha-acetamido-beta-Mercaptopropionic acid

Lantamed

Larylin nac

Lichtenstein brand OF acetylcysteine

Lindocetyl

Lindopharm brand OF acetylcysteine

Lysox

L-α-acetamido-β-mercaptopropionate

L-α-acetamido-β-mercaptopropionic acid

m Pectil

Mentopin acetylcystein

Mercaptate

Mercaptic acid

Mercapturic acid

Merck brand OF acetylcysteine

Monoammonium salt acetylcysteine

Monosodium salt acetylcysteine

m-Pectil

MPectil

Muciteran

muco Sanigen

Mucolysin

Mucomyst

Mucopect, dampo

Mucosil

Mucosol

Mucosolvin

N Acetyl L cysteine

N Acetylcysteine

NAC

NAC al

NAC zambon

NAC, bisolvon

N-Acetyl-3-mercaptoalanine

N-acetylcysteine

N-Acetylcysteine

N-Acety-L-cysteine

N-acetyl-L-(+)-cysteine

N-Acetyl-L-(+)-cysteine

N-acetyl-L-cysteine

Oberlin brand OF acetylcysteine

Optipect hustengetränk

Parvolex

Pfleger brand OF acetylcysteine

Pharbita brand OF acetylcysteine

Produpharm lappe brand OF acetylcysteine

Roberts brand OF acetylcysteine

Roche nicholas brand OF acetylcysteine

Sanigen, muco

Siccoral

Siran

Sodium 2-acetamido-3-mercaptopropionate

Sodium, acetylcysteine

Solmucol

Temmler brand OF acetylcysteine

Teva brand OF acetylcysteine

Thiemann brand OF acetylcysteine

Trommsdorff brand OF acetylcysteine

UPSA brand OF acetylcysteine

Whitehall brand OF acetylcysteine

Zambon brand OF acetylcysteine

Zambon, nac

Zinc, acetylcysteine

Zyma brand OF acetylcysteine

Doxil

Approved June 1999

Phase 2

31703

Anti-Bacterial Agents

Phase 2

Antiviral Agents

Phase 2,Phase 1

Antimetabolites

Phase 2

Anti-Infective Agents

Phase 2,Phase 1

Immunosuppressive Agents

Phase 2,Phase 1

Antimetabolites, Antineoplastic

Phase 2

Immunologic Factors

Phase 2,Phase 1

Topoisomerase Inhibitors

Phase 2

Albumin-Bound Paclitaxel

Phase 2

Antibiotics, Antitubercular

Phase 2

Antimitotic Agents

Phase 2

topoisomerase I inhibitors

Phase 2

Antineoplastic Agents, Phytogenic

Phase 2

Protective Agents

Phase 2

Respiratory System Agents

Phase 2

cysteine

Phase 2

Free Radical Scavengers

Phase 2

Antidotes

Phase 2

Expectorants

Phase 2

N-monoacetylcystine

Phase 2

Antioxidants

Phase 2

CHI3L1 protein, human

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer	Recruiting	NCT02364713	Phase 2	Gemcitabine Hydrochloride;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride;Topotecan Hydrochloride
2	Effect of Acetylcysteine With Topotecan Hydrochloride on the Tumor Microenvironment in Patients With Persistent or Recurrent High Grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer	Terminated	NCT02569957	Phase 2	Topotecan Hydrochloride;Topotecan Hydrochloride;Acetylcysteine
3	Activated T-cell Therapy, Low-Dose Aldesleukin, and Sargramostim in Treating Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer That is Stage III-IV, Refractory, or Recurrent	Withdrawn	NCT02470559	Phase 1
4	YKL-40 in Serum Samples From Patients With Newly Diagnosed Stage III-IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer Receiving Chemotherapy	Terminated	NCT00899093

Search NIH Clinical Center for Ovary Serous Adenocarcinoma

Sources

Genetic Tests for Ovary Serous Adenocarcinoma

Sources

Anatomical Context for Ovary Serous Adenocarcinoma

MalaCards organs/tissues related to Ovary Serous Adenocarcinoma:

⁴²

Ovary, T Cells, Lymph Node

Sources

Publications for Ovary Serous Adenocarcinoma

Articles related to Ovary Serous Adenocarcinoma:

#	Title	Authors	Year
1	Coexistence of BRAF V600E and TERT Promoter Mutations in Low-grade Serous Carcinoma of Ovary Recurring as Carcinosarcoma in a Lymph Node: Report of a Case. ( 29620581 )	Tavallaee M...Karam AK	2018
2	Invasion patterns of metastatic high-grade serous carcinoma of ovary or fallopian tube associated with BRCA deficiency. ( 24577588 )	Reyes M.C....Soslow R.A.	2014
3	Synchronous occurrence of endometrial stromal nodule with papillary serous carcinoma of ovary: report of a case and brief review of literature. ( 25404842 )	Mitra S....Mukhopadhyay S.	2014
4	Loss of expression of EphB1 protein in serous carcinoma of ovary associated with metastasis and poor survival. ( 24427352 )	Wang H....Wang J.	2014
5	Choriocarcinoma arising in a serous carcinoma of ovary: an example of histopathology driving treatment. ( 20707961 )	Hafezi-Bakhtiari S....Colgan T.J.	2010

Sources

Genes for Ovary Serous Adenocarcinoma

Genes related to Ovary Serous Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KCNMA1	Potassium Calcium-Activated Channel Subfamily M Alpha 1	Protein Coding	15.64	DISEASES inferred ¹⁵
2	TERT	Telomerase Reverse Transcriptase	Protein Coding	14.46	DISEASES inferred ¹⁵
3	EPHA1	EPH Receptor A1	Protein Coding	13.81	DISEASES inferred ¹⁵
4	NBEAL1	Neurobeachin Like 1	Protein Coding	7.43	GeneCards inferred via : Expressions (show sections)
5	EPHB1	EPH Receptor B1	Protein Coding	6.51	DISEASES inferred ¹⁵
6	GKN2	Gastrokine 2	Protein Coding	4.09	DISEASES inferred ¹⁵

Sources

Variations for Ovary Serous Adenocarcinoma

Cosmic variations for Ovary Serous Adenocarcinoma:

⁹ (show top 50) (show all 1230)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location
1	COSM6906506	ZFHX3	ovary,NS,carcinoma,serous carcinoma	c.794A>C	p.D265A	16:72959352-72959352
2	COSM6914646	YES1	ovary,NS,carcinoma,serous carcinoma	c.194C>T	p.S65F	18:756634-756634
3	COSM6969549	XRCC2	ovary,NS,carcinoma,serous carcinoma	c.121G>C	p.G41R	7:152660701-152660701
4	COSM6910241	XPO1	ovary,NS,carcinoma,serous carcinoma	c.1072T>C	p.S358P	2:61494067-61494067
5	COSM3446768	WT1	ovary,NS,carcinoma,serous carcinoma	c.1285G>A	p.D429N	11:32389123-32389123
6	COSM20660	WNK2	ovary,NS,carcinoma,serous carcinoma	c.1486G>T	p.V496L	9:93239962-93239962
7	COSM20717	WNK1	ovary,NS,carcinoma,serous carcinoma	c.2829C>T	p.Y943Y	12:880028-880028
8	COSM1035874	VHL	ovary,NS,carcinoma,serous carcinoma	c.430G>A	p.G144R	3:10146603-10146603
9	COSM6923147	TSC2	ovary,NS,carcinoma,serous carcinoma	c.4998C>A	p.F1666L	16:2087871-2087871
10	COSM6975218	TSC2	ovary,NS,carcinoma,serous carcinoma	c.1361+1G>A	p.?	16:2062601-2062601
11	COSM6908724	TSC2	ovary,NS,carcinoma,serous carcinoma	c.1217G>A	p.R406K	16:2061968-2061968
12	COSM6923138	TSC2	ovary,NS,carcinoma,serous carcinoma	c.272C>T	p.P91L	16:2053388-2053388
13	COSM20664	TRRAP	ovary,NS,carcinoma,serous carcinoma	c.2677C>T	p.R893C	7:98921807-98921807
14	COSM20653	TRPM7	ovary,NS,carcinoma,serous carcinoma	c.1217C>G	p.S406C	15:50628237-50628237
15	COSM20649	TRIM24	ovary,NS,carcinoma,serous carcinoma	c.959T>C	p.I320T	7:138529193-138529193
16	COSM10794	TP53	ovary,NS,carcinoma,serous carcinoma	c.796G>A	p.G266R	17:7673824-7673824
17	COSM10660	TP53	ovary,NS,carcinoma,serous carcinoma	c.818G>A	p.R273H	17:7673802-7673802
18	COSM10662	TP53	ovary,NS,carcinoma,serous carcinoma	c.743G>A	p.R248Q	17:7674220-7674220
19	COSM43555	TP53	ovary,NS,carcinoma,serous carcinoma	c.736A>G	p.M246V	17:7674227-7674227
20	COSM10704	TP53	ovary,NS,carcinoma,serous carcinoma	c.844C>T	p.R282W	17:7673776-7673776
21	COSM44769	TP53	ovary,NS,carcinoma,serous carcinoma	c.755T>C	p.L252P	17:7674208-7674208
22	COSM10656	TP53	ovary,NS,carcinoma,serous carcinoma	c.742C>T	p.R248W	17:7674221-7674221
23	COSM10654	TP53	ovary,NS,carcinoma,serous carcinoma	c.637C>T	p.R213*	17:7674894-7674894
24	COSM44063	TP53	ovary,NS,carcinoma,serous carcinoma	c.389T>G	p.L130R	17:7675223-7675223
25	COSM10731	TP53	ovary,NS,carcinoma,serous carcinoma	c.707A>G	p.Y236C	17:7674256-7674256
26	COSM10646	TP53	ovary,NS,carcinoma,serous carcinoma	c.725G>A	p.C242Y	17:7674238-7674238
27	COSM10648	TP53	ovary,NS,carcinoma,serous carcinoma	c.524G>A	p.R175H	17:7675088-7675088
28	COSM44901	TP53	ovary,NS,carcinoma,serous carcinoma	c.532C>G	p.H178D	17:7675080-7675080
29	COSM10786	TP53	ovary,NS,carcinoma,serous carcinoma	c.949C>T	p.Q317*	17:7673579-7673579
30	COSM10758	TP53	ovary,NS,carcinoma,serous carcinoma	c.659A>G	p.Y220C	17:7674872-7674872
31	COSM10889	TP53	ovary,NS,carcinoma,serous carcinoma	c.536A>G	p.H179R	17:7675076-7675076
32	COSM10663	TP53	ovary,NS,carcinoma,adenocarcinoma	c.916C>T	p.R306*	17:7673704-7673704
33	COSM10870	TP53	ovary,NS,carcinoma,serous carcinoma	c.523C>G	p.R175G	17:7675089-7675089
34	COSM10705	TP53	ovary,NS,carcinoma,serous carcinoma	c.586C>T	p.R196*	17:7674945-7674945
35	COSM11524	TP53	ovary,NS,carcinoma,serous carcinoma	c.730G>T	p.G244C	17:7674233-7674233
36	COSM43912	TP53	ovary,NS,carcinoma,serous carcinoma	c.395A>C	p.K132T	17:7675217-7675217
37	COSM10733	TP53	ovary,NS,carcinoma,serous carcinoma	c.574C>T	p.Q192*	17:7674957-7674957
38	COSM10891	TP53	ovary,NS,carcinoma,serous carcinoma	c.814G>A	p.V272M	17:7673806-7673806
39	COSM10808	TP53	ovary,NS,carcinoma,serous carcinoma	c.488A>G	p.Y163C	17:7675124-7675124
40	COSM44512	TP53	ovary,NS,carcinoma,serous carcinoma	c.740A>G	p.N247S	17:7674223-7674223
41	COSM11089	TP53	ovary,NS,carcinoma,serous carcinoma	c.584T>C	p.I195T	17:7674947-7674947
42	COSM6901	TP53	ovary,NS,carcinoma,serous carcinoma	c.559+1G>A	p.?	17:7675052-7675052
43	COSM44205	TP53	ovary,NS,carcinoma,serous carcinoma	c.431A>C	p.Q144P	17:7675181-7675181
44	COSM11501	TP53	ovary,NS,carcinoma,serous carcinoma	c.823T>G	p.C275G	17:7673797-7673797
45	COSM10863	TP53	ovary,NS,carcinoma,serous carcinoma	c.833C>T	p.P278L	17:7673787-7673787
46	COSM43963	TP53	ovary,NS,carcinoma,serous carcinoma	c.396G>C	p.K132N	17:7675216-7675216
47	COSM11582	TP53	ovary,NS,carcinoma,serous carcinoma	c.395A>G	p.K132R	17:7675217-7675217
48	COSM10659	TP53	ovary,NS,carcinoma,serous carcinoma	c.817C>T	p.R273C	17:7673803-7673803
49	COSM10958	TP53	ovary,NS,carcinoma,serous carcinoma	c.797G>T	p.G266V	17:7673823-7673823
50	COSM43700	TP53	ovary,NS,carcinoma,serous carcinoma	c.712T>A	p.C238S	17:7674251-7674251

Sources

Expression for Ovary Serous Adenocarcinoma

Search GEO for disease gene expression data for Ovary Serous Adenocarcinoma.

Sources

Pathways for Ovary Serous Adenocarcinoma

Pathways related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Tyrosine Kinases / Adaptors ⁴	10.79	EPHA1 EPHB1

Sources

GO Terms for Ovary Serous Adenocarcinoma

Biological processes related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein autophosphorylation	GO:0046777	9.32	EPHA1 EPHB1
2	positive regulation of angiogenesis	GO:0045766	9.26	EPHA1 TERT
3	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.16	EPHA1 EPHB1
4	negative regulation of apoptotic process	GO:0043066	8.65	TERT
5	ephrin receptor signaling pathway	GO:0048013	8.62	EPHA1 EPHB1

Molecular functions related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	9.26	EPHA1 EPHB1
2	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.16	EPHA1 EPHB1
3	transmembrane-ephrin receptor activity	GO:0005005	8.96	EPHA1 EPHB1
4	ephrin receptor activity	GO:0005003	8.62	EPHA1 EPHB1

Sources

Sources for Ovary Serous Adenocarcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia