MCID: OVR062
MIFTS: 24

Ovary Serous Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Ovary Serous Adenocarcinoma

MalaCards integrated aliases for Ovary Serous Adenocarcinoma:

Name: Ovary Serous Adenocarcinoma 12 15
Malignant Ovarian Serous Tumor 12 73
Serous Carcinoma of Ovary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5744
NCIt 50 C40025 C7550

Summaries for Ovary Serous Adenocarcinoma

Disease Ontology : 12 An ovary adenocarcinoma that derives from the lining of a cavity that produces a serum-like fluid (a serous cavity).

MalaCards based summary : Ovary Serous Adenocarcinoma, also known as malignant ovarian serous tumor, is related to ovarian serous cystadenocarcinoma and endometrial stromal nodule. An important gene associated with Ovary Serous Adenocarcinoma is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways is Tyrosine Kinases / Adaptors. Affiliated tissues include ovary and lymph node, and related phenotype is Decreased substrate adherent cell growth.

Related Diseases for Ovary Serous Adenocarcinoma

Diseases related to Ovary Serous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ovarian serous cystadenocarcinoma 11.3
2 endometrial stromal nodule 9.9
3 choriocarcinoma 9.9
4 carcinosarcoma 9.9

Symptoms & Phenotypes for Ovary Serous Adenocarcinoma

GenomeRNAi Phenotypes related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-2 8.62 EPHA1 EPHB1

Drugs & Therapeutics for Ovary Serous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Ovary Serous Adenocarcinoma

Genetic Tests for Ovary Serous Adenocarcinoma

Anatomical Context for Ovary Serous Adenocarcinoma

MalaCards organs/tissues related to Ovary Serous Adenocarcinoma:

41
Ovary, Lymph Node

Publications for Ovary Serous Adenocarcinoma

Articles related to Ovary Serous Adenocarcinoma:

# Title Authors Year
1
Coexistence of BRAF V600E and TERT Promoter Mutations in Low-grade Serous Carcinoma of Ovary Recurring as Carcinosarcoma in a Lymph Node: Report of a Case. ( 29620581 )
2018
2
Invasion patterns of metastatic high-grade serous carcinoma of ovary or fallopian tube associated with BRCA deficiency. ( 24577588 )
2014
3
Synchronous occurrence of endometrial stromal nodule with papillary serous carcinoma of ovary: report of a case and brief review of literature. ( 25404842 )
2014
4
Loss of expression of EphB1 protein in serous carcinoma of ovary associated with metastasis and poor survival. ( 24427352 )
2014
5
Choriocarcinoma arising in a serous carcinoma of ovary: an example of histopathology driving treatment. ( 20707961 )
2010

Variations for Ovary Serous Adenocarcinoma

Cosmic variations for Ovary Serous Adenocarcinoma:

9 (show top 50) (show all 1230)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10663 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 8
2 COSM11066 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 8
3 COSM10738 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 8
4 COSM11148 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 8
5 COSM6904336 TNFAIP3 ovary,NS,carcinoma,adenocarcinoma c.940G>A p.V314I 6:137877210-137877210 8
6 COSM14135 SMAD4 ovary,NS,carcinoma,adenocarcinoma c.1051G>C p.D351H 18:51065518-51065518 8
7 COSM6904335 SMAD2 ovary,NS,carcinoma,adenocarcinoma c.785-1G>C p.? 18:47848688-47848688 8
8 COSM6904334 RET ovary,NS,carcinoma,adenocarcinoma c.3253A>G p.T1085A 10:43128177-43128177 8
9 COSM6904339 PTCH1 ovary,NS,carcinoma,adenocarcinoma c.3074G>A p.R1025H 9:95458107-95458107 8
10 COSM770 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.2725T>C p.F909L 3:179230062-179230062 8
11 COSM21446 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.3012G>T p.M1004I 3:179234169-179234169 8
12 COSM746 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 8
13 COSM94978 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1034A>T p.N345I 3:179203764-179203764 8
14 COSM766 PIK3CA ovary,NS,carcinoma,adenocarcinoma c.1636C>A p.Q546K 3:179218306-179218306 8
15 COSM564 NRAS ovary,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 1:114716126-114716126 8
16 COSM14065 ERBB2 ovary,NS,carcinoma,adenocarcinoma c.2524G>A p.V842I 17:39725079-39725079 8
17 COSM22992 EGFR ovary,NS,carcinoma,adenocarcinoma c.2161G>A p.G721S 7:55174020-55174020 8
18 COSM53264 EGFR ovary,NS,carcinoma,adenocarcinoma c.2174C>T p.T725M 7:55174033-55174033 8
19 COSM6224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2573T>G p.L858R 7:55191822-55191822 8
20 COSM53230 EGFR ovary,NS,carcinoma,adenocarcinoma c.2597A>G p.E866G 7:55191846-55191846 8
21 COSM28511 EGFR ovary,NS,carcinoma,adenocarcinoma c.2108T>C p.L703P 7:55173967-55173967 8
22 COSM53225 EGFR ovary,NS,carcinoma,adenocarcinoma c.2112G>A p.L704L 7:55173971-55173971 8
23 COSM53232 EGFR ovary,NS,carcinoma,adenocarcinoma c.2122A>G p.K708E 7:55173981-55173981 8
24 COSM53226 EGFR ovary,NS,carcinoma,adenocarcinoma c.2099A>G p.N700S 7:55173958-55173958 8
25 COSM53266 EGFR ovary,NS,carcinoma,adenocarcinoma c.2165C>T p.A722V 7:55174024-55174024 8
26 COSM53224 EGFR ovary,NS,carcinoma,adenocarcinoma c.2173A>G p.T725A 7:55174032-55174032 8
27 COSM53213 EGFR ovary,NS,carcinoma,adenocarcinoma c.2604A>T p.E868D 7:55191853-55191853 8
28 COSM53229 EGFR ovary,NS,carcinoma,adenocarcinoma c.2232C>A p.I744I 7:55174769-55174769 8
29 COSM53231 EGFR ovary,NS,carcinoma,adenocarcinoma c.2559C>T p.I853I 7:55191808-55191808 8
30 COSM12373 EGFR ovary,NS,carcinoma,adenocarcinoma c.2159C>T p.S720F 7:55174018-55174018 8
31 COSM53265 EGFR ovary,NS,carcinoma,adenocarcinoma c.2556G>T p.K852N 7:55191805-55191805 8
32 COSM53235 EGFR ovary,NS,carcinoma,adenocarcinoma c.2481C>T p.Y827Y 7:55191730-55191730 8
33 COSM28286 EGFR ovary,NS,carcinoma,adenocarcinoma c.2494C>T p.R832C 7:55191743-55191743 8
34 COSM53228 EGFR ovary,NS,carcinoma,adenocarcinoma c.2123A>G p.K708R 7:55173982-55173982 8
35 COSM53227 EGFR ovary,NS,carcinoma,adenocarcinoma c.2506C>A p.R836S 7:55191755-55191755 8
36 COSM22499 ATM ovary,NS,carcinoma,adenocarcinoma c.1810C>T p.P604S 11:108252824-108252824 8
37 COSM6904304 AR ovary,NS,carcinoma,adenocarcinoma c.2179C>T p.R727C 23:67717483-67717483 8
38 COSM159008 AKT1 ovary,NS,carcinoma,adenocarcinoma c.235C>A p.Q79K 14:104776711-104776711 8
39 COSM6906506 ZFHX3 ovary,NS,carcinoma,serous carcinoma c.794A>C p.D265A 16:72959352-72959352 6
40 COSM6914646 YES1 ovary,NS,carcinoma,serous carcinoma c.194C>T p.S65F 18:756634-756634 6
41 COSM6969549 XRCC2 ovary,NS,carcinoma,serous carcinoma c.121G>C p.G41R 7:152660701-152660701 6
42 COSM6910241 XPO1 ovary,NS,carcinoma,serous carcinoma c.1072T>C p.S358P 2:61494067-61494067 6
43 COSM3446768 WT1 ovary,NS,carcinoma,serous carcinoma c.1285G>A p.D429N 11:32389123-32389123 6
44 COSM20660 WNK2 ovary,NS,carcinoma,serous carcinoma c.1486G>T p.V496L 9:93239962-93239962 6
45 COSM20717 WNK1 ovary,NS,carcinoma,serous carcinoma c.2829C>T p.Y943Y 12:880028-880028 6
46 COSM1035874 VHL ovary,NS,carcinoma,serous carcinoma c.430G>A p.G144R 3:10146603-10146603 6
47 COSM6923147 TSC2 ovary,NS,carcinoma,serous carcinoma c.4998C>A p.F1666L 16:2087871-2087871 6
48 COSM6975218 TSC2 ovary,NS,carcinoma,serous carcinoma c.1361+1G>A p.? 16:2062601-2062601 6
49 COSM6908724 TSC2 ovary,NS,carcinoma,serous carcinoma c.1217G>A p.R406K 16:2061968-2061968 6
50 COSM6923138 TSC2 ovary,NS,carcinoma,serous carcinoma c.272C>T p.P91L 16:2053388-2053388 6

Expression for Ovary Serous Adenocarcinoma

Search GEO for disease gene expression data for Ovary Serous Adenocarcinoma.

Pathways for Ovary Serous Adenocarcinoma

Pathways related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 EPHA1 EPHB1

GO Terms for Ovary Serous Adenocarcinoma

Biological processes related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.4 EPHA1 EPHB1
2 positive regulation of angiogenesis GO:0045766 9.37 EPHA1 TERT
3 positive regulation of MAPK cascade GO:0043410 9.32 EPHA1 EPHB1
4 negative regulation of signal transduction GO:0009968 9.26 EPHA1 EPHB1
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.16 EPHA1 EPHB1
6 negative regulation of apoptotic process GO:0043066 9.13 EPHA1 EPHB1 TERT
7 ephrin receptor signaling pathway GO:0048013 8.62 EPHA1 EPHB1

Molecular functions related to Ovary Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.26 EPHA1 EPHB1
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 EPHA1 EPHB1
3 transmembrane-ephrin receptor activity GO:0005005 8.96 EPHA1 EPHB1
4 ephrin receptor activity GO:0005003 8.62 EPHA1 EPHB1

Sources for Ovary Serous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....