MCID: OVR082
MIFTS: 50

Overgrowth Syndrome

Categories: Cardiovascular diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Overgrowth Syndrome

MalaCards integrated aliases for Overgrowth Syndrome:

Name: Overgrowth Syndrome 58 29
Overgrowth 29 6

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q87.3
Orphanet 58 ORPHA93460

Summaries for Overgrowth Syndrome

MalaCards based summary : Overgrowth Syndrome, also known as overgrowth, is related to facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome and proteus syndrome. An important gene associated with Overgrowth Syndrome is NSD1 (Nuclear Receptor Binding SET Domain Protein 1), and among its related pathways/superpathways are MicroRNAs in cancer and Nectin adhesion pathway. The drugs Clindamycin and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Overgrowth Syndrome

Diseases in the Overgrowth Syndrome family:

Eed-Related Overgrowth Ezh2-Related Overgrowth
Pik3ca-Related Overgrowth Spectrum Pik3ca-Related Overgrowth Syndrome

Diseases related to Overgrowth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 839, show less)
# Related Disease Score Top Affiliating Genes
1 facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome 34.1 KCNK4-TEX40 KCNK4
2 proteus syndrome 32.3 PIK3CA NSD1 GPC3
3 perlman syndrome 32.1 GPC3 DIS3L2
4 epiphyseal chondrodysplasia, miura type 32.1 NPR2 NPPC
5 weaver syndrome 31.7 SETD2 NSD1 GPC3 DNMT3A DIS3L2
6 silver-russell syndrome 31.3 NSD1 IGF2 H19-ICR
7 beckwith-wiedemann syndrome 31.2 NSD1 IGF2 H19-ICR GPC3 DNMT3A
8 sotos syndrome 1 30.9 SETD2 NSD1 NFIX GPC3 DNMT3A APC2
9 macrodactyly 30.2 PIK3CA NPR2
10 marshall-smith syndrome 29.9 NSD1 NFIX
11 wilms tumor 5 29.5 IGF2 GPC3
12 acromesomelic dysplasia 29.4 NPR2 NPPC
13 wilms tumor predisposition 28.7 NSD1 IGF2 H19-ICR GPC3 DIS3L2
14 kosaki overgrowth syndrome 12.6
15 capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth 12.6
16 global developmental delay, lung cysts, overgrowth, and wilms tumor 12.5
17 gingival overgrowth 12.4
18 dnmt3a overgrowth syndrome 12.4
19 acromegaloid features, overgrowth, cleft palate, and hernia 12.3
20 overgrowth-macrocephaly-facial dysmorphism syndrome 12.3
21 metaphyseal undermodeling, spondylar dysplasia, and overgrowth 12.3
22 vertebral body fusion overgrowth 12.3
23 pik3ca-related overgrowth syndrome 12.2
24 eed-related overgrowth 12.2
25 segmental progressive overgrowth syndrome with fibroadipose hyperplasia 12.1
26 overgrowth syndrome with 2q37 translocation 12.1
27 genetic overgrowth/obesity syndrome 12.1
28 overgrowth/obesity syndrome 12.1
29 obsolete: congenital vascular bone syndrome with limb overgrowth 12.1
30 non syndromic limb overgrowth 12.1
31 overgrowth or tall stature syndrome with skeletal involvement 12.1
32 chromosomal disease with overgrowth 12.1
33 tatton-brown-rahman syndrome 12.0
34 simpson-golabi-behmel syndrome 11.9
35 sotos syndrome 2 11.7
36 macrocephaly, dysmorphic facies, and psychomotor retardation 11.7
37 rahman syndrome 11.6
38 fibromatosis, gingival, 1 11.6
39 blind loop syndrome 11.5
40 sclerosteosis 11.5
41 nevus, epidermal 11.4
42 capillary malformation-arteriovenous malformation 1 11.4
43 loeys-dietz syndrome 5 11.4
44 developmental delay with variable intellectual impairment and behavioral abnormalities 11.4
45 simpson-golabi-behmel syndrome, type 1 11.4
46 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 11.4
47 hemihyperplasia, isolated 11.3
48 megalencephaly-capillary malformation-polymicrogyria syndrome 11.3
49 momo syndrome 11.3
50 tenorio syndrome 11.3
51 fibromatosis 11.3
52 pyogenic granuloma 11.3
53 gingival fibromatosis 11.3
54 tuberous sclerosis 1 11.3
55 costello syndrome 11.3
56 keloid disorder 11.3
57 ossifying fibroma 11.3
58 breast malignant phyllodes tumor 11.3
59 corneal dystrophy, posterior polymorphous, 1 11.3
60 mucolipidosis ii alpha/beta 11.3
61 chromosome xq26.3 duplication syndrome 11.3
62 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 11.3
63 sclerosteosis 2 11.3
64 clostridium difficile colitis 11.3
65 familial isolated pituitary adenoma 11.3
66 inflammatory linear verrucous epidermal nevus 11.3
67 post-transplant lymphoproliferative disease 11.3
68 proteus-like syndrome 11.3
69 craniometaphyseal dysplasia, autosomal dominant 11.2
70 laryngoonychocutaneous syndrome 11.2
71 ehlers-danlos syndrome, kyphoscoliotic type, 1 11.2
72 tetrasomy 15q26 11.1
73 barnicoat baraitser syndrome 11.1
74 hairy tongue 11.1
75 richieri-costa guion-almeida cohen syndrome 11.1
76 hyperostosis cranialis interna 11.1
77 amelogenesis imperfecta, type ig 11.1
78 van buchem disease 11.1
79 pleuropulmonary blastoma 11.1
80 histiocytosis-lymphadenopathy plus syndrome 11.1
81 rippling muscle disease 2 11.1
82 fibromatosis, gingival, 5 11.1
83 x-linked congenital generalized hypertrichosis 11.1
84 hypertrichosis, congenital generalized, with or without gingival hyperplasia 11.0
85 cowden syndrome 1 11.0
86 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 11.0
87 thauvin-robinet-faivre syndrome 11.0
88 sotos syndrome 3 11.0
89 hemi 3 syndrome 11.0
90 cherubism 10.9
91 beare-stevenson cutis gyrata syndrome 10.9
92 fibromatosis, gingival, with progressive deafness 10.9
93 gastritis, familial giant hypertrophic 10.9
94 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.9
95 beukes hip dysplasia 10.9
96 chromosome 8q22.1 duplication syndrome 10.9
97 schimmelpenning-feuerstein-mims syndrome 10.9
98 polycystic liver disease 1 with or without kidney cysts 10.9
99 uterine anomalies 10.9
100 white sponge nevus 1 10.9
101 craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome 10.9
102 craniometaphyseal dysplasia, autosomal recessive 10.9
103 acth-independent macronodular adrenal hyperplasia 10.9
104 hyaline fibromatosis syndrome 10.9
105 multicentric osteolysis, nodulosis, and arthropathy 10.9
106 sclerosteosis 1 10.9
107 winchester syndrome 10.9
108 simpson-golabi-behmel syndrome, type 2 10.9
109 brachydactyly, mononen type 10.9
110 trimethylaminuria 10.9
111 alpha-thalassemia 10.9
112 becker nevus syndrome 10.9
113 lymphangioleiomyomatosis 10.9
114 gastrointestinal stromal tumor 10.9
115 cinca syndrome 10.9
116 leukemia, chronic myeloid 10.9
117 fibromatosis, gingival, 4 10.9
118 acute promyelocytic leukemia 10.9
119 tuberous sclerosis 2 10.9
120 mitochondrial dna depletion syndrome 4b 10.9
121 polycystic liver disease 2 with or without kidney cysts 10.9
122 polycystic liver disease 3 with or without kidney cysts 10.9
123 polycystic liver disease 4 with or without kidney cysts 10.9
124 congenital generalized lipodystrophy 10.9
125 robinow syndrome 10.9
126 hennekam syndrome 10.9
127 baritosis 10.9
128 chronic mucocutaneous candidiasis 10.9
129 pigmented villonodular synovitis 10.9
130 tenosynovial giant cell tumor 10.9
131 glycoproteinosis 10.9
132 pelvic lipomatosis 10.9
133 diffuse idiopathic skeletal hyperostosis 10.9
134 limb-girdle muscular dystrophy 10.9
135 cutaneous-skeletal hypophosphatemia syndrome 10.9
136 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 10.9
137 intravascular papillary endothelial hyperplasia 10.9
138 juvenile ossifying fibroma 10.9
139 macrodactyly of fingers 10.9
140 ogilvie syndrome 10.9
141 osteochondroma 10.9
142 pseudoangiomatous stromal hyperplasia 10.9
143 rokitansky-aschoff sinuses of the gallbladder 10.9
144 cav3-related distal myopathy 10.9
145 recombinant 8 syndrome 10.9
146 irritable bowel syndrome 10.7
147 adenosarcoma 10.4
148 gingivitis 10.4
149 periodontitis 10.3
150 liver disease 10.3
151 cebpa-associated familial acute myeloid leukemia 10.3 NSD1 DNMT3A
152 sarcomatous intrahepatic cholangiocarcinoma 10.3 PDGFRB GPC3
153 gestational diabetes 10.2
154 peritonitis 10.2
155 fatty liver disease 10.2
156 alacrima, achalasia, and mental retardation syndrome 10.2
157 non-alcoholic steatohepatitis 10.2
158 scoliosis 10.2
159 fibroma 10.2
160 non-alcoholic fatty liver disease 10.2
161 short bowel syndrome 10.2
162 adenosarcoma of the uterus 10.2
163 cystic fibrosis 10.2
164 frontal convexity meningioma 10.2 PIK3CA PDGFRB
165 scleroderma, familial progressive 10.1
166 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
167 periodontitis, chronic 10.1
168 lactose intolerance 10.1
169 gastritis 10.1
170 pancreatitis 10.1
171 pax6-related aniridia 10.1 IGF2 GPC3
172 beckwith-wiedemann syndrome due to 11p15 microdeletion 10.1
173 beckwith-wiedemann syndrome due to 11p15 translocation/inversion 10.1
174 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.1
175 beckwith-wiedemann syndrome due to paternal uniparental disomy of chromosome 11 10.1
176 beckwith-wiedemann syndrome due to 11p15 microduplication 10.1
177 klippel-trenaunay-weber syndrome 10.1
178 diarrhea 10.1
179 paraphimosis 10.1 NPR2 NPPC
180 camptodactyly-tall stature-scoliosis-hearing loss syndrome 10.1 NPR2 NPPC
181 scoliosis, isolated 1 10.1
182 helicobacter pylori infection 10.1
183 idiopathic scoliosis 10.1
184 intestinal disease 10.1
185 peptic ulcer disease 10.1
186 hepatic coma 10.1
187 hepatic encephalopathy 10.1
188 hypothyroidism 10.1
189 ankylosis 10.1
190 endometriosis 10.1
191 hyperglycemia 10.1
192 learning disability 10.1
193 gigantism 10.1
194 hydrocephalus 10.0
195 hair whorl 10.0
196 pectus excavatum 10.0
197 methane production 10.0
198 hyperinsulinism 10.0
199 dermatitis 10.0
200 rosacea 10.0
201 atrophic gastritis 10.0
202 encephalopathy 10.0
203 achondroplasia 10.0
204 autoimmune disease 10.0
205 gastroesophageal reflux 10.0
206 cryptorchidism, unilateral or bilateral 10.0
207 insulin-like growth factor i 10.0
208 leptin deficiency or dysfunction 10.0
209 oral squamous cell carcinoma 10.0
210 immunoglobulin alpha deficiency 10.0
211 rhabdomyosarcoma 10.0
212 epulis 10.0
213 hemimegalencephaly 10.0
214 neurofibromatosis, type iv, of riccardi 10.0
215 chromosome 2q35 duplication syndrome 10.0
216 autism 10.0
217 macrocephaly/megalencephaly syndrome, autosomal recessive 10.0
218 ezh2-related overgrowth 10.0
219 weber syndrome 10.0
220 megalencephaly 10.0
221 acromesomelic dysplasia, maroteaux type 10.0 NPR2 NPPC
222 colorectal cancer 9.9
223 strabismus 9.9
224 varicose veins 9.9
225 proteasome-associated autoinflammatory syndrome 1 9.9
226 gonadoblastoma 9.9
227 gallbladder disease 1 9.9
228 dermatitis, atopic 9.9
229 fatty liver disease, nonalcoholic 1 9.9
230 vitamin b12 deficiency 9.9
231 cervical polyp 9.9
232 bacterial infectious disease 9.9
233 amelogenesis imperfecta 9.9
234 gastroenteritis 9.9
235 macrocytic anemia 9.9
236 vaginal adenosarcoma 9.9
237 hypertrichosis 9.9
238 duodenitis 9.9
239 mechanical strabismus 9.9
240 congenital amputation 9.9
241 dysphagia 9.9
242 polydactyly 9.9
243 autism spectrum disorder 9.9
244 umbilical hernia 9.9
245 lipomatosis 9.9
246 hypoglycemia 9.9
247 chromosomal triplication 9.9
248 arteries, anomalies of 9.9
249 fibrosis of extraocular muscles, congenital, 1 9.9
250 enterocolitis 9.9
251 ataxia and polyneuropathy, adult-onset 9.9
252 body mass index quantitative trait locus 1 9.9
253 gastric cancer 9.9
254 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
255 hyperlipoproteinemia, type iii 9.9
256 colitis 9.9
257 thrombosis 9.9
258 bone disease 9.9
259 glucose intolerance 9.9
260 gastric ulcer 9.9
261 prostatic hypertrophy 9.9
262 sarcoma 9.9
263 coronary artery anomaly 9.9
264 leiomyoma 9.9
265 obstructive hydrocephalus 9.9
266 dumping syndrome 9.9
267 gingival disease 9.9
268 keratosis 9.9
269 benign breast phyllodes tumor 9.9
270 duodenal ulcer 9.9
271 mitral valve stenosis 9.9
272 synovitis 9.9
273 prostatic adenoma 9.9
274 mammary paget's disease 9.9
275 cervical adenosarcoma 9.9
276 spindle cell sarcoma 9.9
277 polyhydramnios 9.9
278 diabetes mellitus 9.9
279 cholangitis 9.9
280 47,xyy 9.9
281 cytokine deficiency 9.9
282 dwarfism 9.9
283 fetal macrosomia 9.9
284 lymphangiectasis 9.9
285 temporomandibular ankylosis 9.9
286 renal dysplasia 9.9
287 macroglossia 9.8
288 polydactyly, postaxial, type a1 9.8
289 dowling-degos disease 1 9.8
290 wolf-hirschhorn syndrome 9.8
291 hydrocephalus, congenital, 1 9.8
292 leukemia, acute myeloid 9.8
293 congenital short bowel syndrome 9.8
294 polymicrogyria with or without vascular-type ehlers-danlos syndrome 9.8
295 deficiency anemia 9.8
296 pulmonary hypertension 9.8
297 loeys-dietz syndrome 9.8
298 inflammatory bowel disease 9.8
299 basal ganglia calcification 9.8
300 infantile myofibromatosis 9.8
301 hyperostosis 9.8
302 constipation 9.8
303 craniosynostosis 9.8
304 myofibroma 9.8
305 cowden syndrome 9.8
306 hepatoblastoma 9.8
307 neuroblastoma 9.8
308 intestinal obstruction 9.8
309 ulcerative colitis 9.8
310 myeloid leukemia 9.8
311 crohn's disease 9.8
312 pik3ca-related segmental overgrowth 9.8
313 polymicrogyria 9.8
314 pik3ca-related overgrowth spectrum 9.8
315 slipped capital femoral epiphysis 9.8
316 hypotonia 9.8
317 premature aging 9.8
318 multiple congenital anomalies/dysmorphic syndrome-intellectual disability 9.8
319 acanthosis nigricans 9.8
320 atherosclerosis susceptibility 9.8
321 breast cancer 9.8
322 hepatocellular carcinoma 9.8
323 coxa vara 9.8
324 multiple sclerosis 9.8
325 esophageal cancer 9.8
326 hand skill, relative 9.8
327 legg-calve-perthes disease 9.8
328 lipomatosis, multiple 9.8
329 melanoma, uveal 9.8
330 retinoblastoma 9.8
331 rheumatoid arthritis 9.8
332 triiodothyronine receptor auxiliary protein 9.8
333 osteoid osteoma 9.8
334 pancreatic cancer 9.8
335 thymoma, familial 9.8
336 hypomelanosis of ito 9.8
337 yemenite deaf-blind hypopigmentation syndrome 9.8
338 bone mineral density quantitative trait locus 3 9.8
339 hydrops, lactic acidosis, and sideroblastic anemia 9.8
340 restless legs syndrome 9.8
341 autosomal recessive disease 9.8
342 pervasive developmental disorder 9.8
343 ileitis 9.8
344 ileocolitis 9.8
345 inguinal hernia 9.8
346 sensorineural hearing loss 9.8
347 monocular esotropia 9.8
348 endocarditis 9.8
349 pre-eclampsia 9.8
350 tropical sprue 9.8
351 portal hypertension 9.8
352 alport syndrome 9.8
353 clubfoot 9.8
354 allergic hypersensitivity disease 9.8
355 primary biliary cirrhosis 9.8
356 exocrine pancreatic insufficiency 9.8
357 ehlers-danlos syndrome 9.8
358 megaloblastic anemia 9.8
359 candidiasis 9.8
360 alcohol use disorder 9.8
361 thrombocytopenia 9.8
362 melanoma 9.8
363 hypogonadism 9.8
364 exostosis 9.8
365 neonatal jaundice 9.8
366 ovarian brenner tumor 9.8
367 bilirubin metabolic disorder 9.8
368 acute pancreatitis 9.8
369 adenocarcinoma 9.8
370 cutis laxa 9.8
371 neurilemmoma 9.8
372 lysosomal storage disease 9.8
373 thymoma 9.8
374 teratoma 9.8
375 mesenchymal cell neoplasm 9.8
376 breast adenocarcinoma 9.8
377 arthropathy 9.8
378 myopathy 9.8
379 carcinosarcoma 9.8
380 dysgerminoma 9.8
381 familial retinoblastoma 9.8
382 leiomyomatosis 9.8
383 mature teratoma 9.8
384 kidney disease 9.8
385 intravenous leiomyomatosis 9.8
386 peripheral nervous system disease 9.8
387 uterine carcinosarcoma 9.8
388 fibromyalgia 9.8
389 adenoma 9.8
390 hypogonadotropism 9.8
391 diverticulitis 9.8
392 arthritis 9.8
393 perinatal necrotizing enterocolitis 9.8
394 pulmonary embolism 9.8
395 neurofibroma 9.8
396 esotropia 9.8
397 hypereosinophilic syndrome 9.8
398 hypertrophic cardiomyopathy 9.8
399 48,xyyy 9.8
400 chiari malformation 9.8
401 diencephalic syndrome 9.8
402 exencephaly 9.8
403 pectus carinatum 9.8
404 precocious puberty 9.8
405 uterine sarcoma 9.8
406 abdominal wall defect 9.8
407 hypoxia 9.8
408 spinal cord injury 9.8
409 mosaic trisomy 12 9.8
410 obsolete: ito hypomelanosis 9.8
411 acute liver failure 9.8
412 paternal uniparental disomy 9.8
413 rare tumor 9.8
414 cleft palate, isolated 9.7
415 coloboma of macula 9.7
416 diaphragmatic hernia, congenital 9.7
417 attention deficit-hyperactivity disorder 9.7
418 hypertelorism 9.7
419 marfan syndrome 9.7
420 meckel diverticulum 9.7
421 neurofibromatosis, type i 9.7
422 obsessive-compulsive disorder 9.7
423 sturge-weber syndrome 9.7
424 renal hypodysplasia/aplasia 1 9.7
425 arachnoid cysts, intracranial 9.7
426 c syndrome 9.7
427 celiac disease 1 9.7
428 cutis marmorata telangiectatica congenita 9.7
429 dandy-walker syndrome 9.7
430 peho syndrome 9.7
431 body mass index quantitative trait locus 11 9.7
432 fragile x syndrome 9.7
433 pallister-killian syndrome 9.7
434 body mass index quantitative trait locus 9 9.7
435 body mass index quantitative trait locus 8 9.7
436 macrocephaly/autism syndrome 9.7
437 body mass index quantitative trait locus 4 9.7
438 body mass index quantitative trait locus 10 9.7
439 body mass index quantitative trait locus 7 9.7
440 body mass index quantitative trait locus 12 9.7
441 body mass index quantitative trait locus 14 9.7
442 chromosome 17q11.2 deletion syndrome, 1.4-mb 9.7
443 body mass index quantitative trait locus 18 9.7
444 acid-labile subunit deficiency 9.7
445 luscan-lumish syndrome 9.7
446 cohen-gibson syndrome 9.7
447 alkuraya-kucinskas syndrome 9.7
448 body mass index quantitative trait locus 19 9.7
449 body mass index quantitative trait locus 20 9.7
450 distal arthrogryposis 9.7
451 sleep apnea 9.7
452 apraxia 9.7
453 crohn's colitis 9.7
454 omphalocele 9.7
455 fibrous dysplasia 9.7
456 polycystic kidney disease 9.7
457 protein-losing enteropathy 9.7
458 hydronephrosis 9.7
459 arteriovenous malformation 9.7
460 megacolon 9.7
461 autonomic neuropathy 9.7
462 dysgammaglobulinemia 9.7
463 visual epilepsy 9.7
464 gastroparesis 9.7
465 chagas disease 9.7
466 leukemia 9.7
467 acute leukemia 9.7
468 tuberous sclerosis 9.7
469 lymphangioma 9.7
470 ectropion 9.7
471 ventricular septal defect 9.7
472 heart septal defect 9.7
473 vascular disease 9.7
474 epilepsy 9.7
475 leiomyosarcoma 9.7
476 hemangioma 9.7
477 benign mesothelioma 9.7
478 skin disease 9.7
479 intestinal pseudo-obstruction 9.7
480 systemic scleroderma 9.7
481 pyoderma 9.7
482 spongiotic dermatitis 9.7
483 pleomorphic adenoma 9.7
484 liver cirrhosis 9.7
485 congestive heart failure 9.7
486 skin tag 9.7
487 gastrointestinal system disease 9.7
488 neuropathy 9.7
489 pathologic nystagmus 9.7
490 postcholecystectomy syndrome 9.7
491 alopecia 9.7
492 muscular dystrophy 9.7
493 microcephaly 9.7
494 bap1 tumor predisposition syndrome 9.7
495 hypermobile ehlers-danlos syndrome 9.7
496 acute leukemia of ambiguous lineage 9.7
497 antisynthetase syndrome 9.7
498 chromosome 15q duplication 9.7
499 chromosome 4p deletion 9.7
500 glioma 9.7
501 horseshoe kidney 9.7
502 parkes weber syndrome 9.7
503 retinochoroidal coloboma 9.7
504 9q22.3 microdeletion 9.7
505 seizure disorder 9.7
506 angioosteohypertrophic syndrome 9.7
507 glial tumor 9.7
508 hemihyperplasia-multiple lipomatosis syndrome 9.7
509 lower limb hypertrophy 9.7
510 congenital amyoplasia 9.7
511 rare vascular disease 9.7
512 acroosteolysis 9.6
513 alcohol dependence 9.6
514 spondyloarthropathy 1 9.6
515 episodic ataxia, type 2 9.6
516 aortic valve disease 1 9.6
517 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.6
518 carpal tunnel syndrome 9.6
519 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 9.6
520 colchicine resistance 9.6
521 cone-rod dystrophy 2 9.6
522 dysplasia epiphysealis hemimelica 9.6
523 ehlers-danlos syndrome, classic type, 1 9.6
524 hashimoto thyroiditis 9.6
525 hirschsprung disease 1 9.6
526 hypercholesterolemia, familial, 1 9.6
527 renal cell carcinoma, nonpapillary 9.6
528 hypochondroplasia 9.6
529 keloid formation 9.6
530 kleine-levin hibernation syndrome 9.6
531 leiomyoma, uterine 9.6
532 systemic lupus erythematosus 9.6
533 treacher collins syndrome 1 9.6
534 mesothelioma, malignant 9.6
535 migraine with or without aura 1 9.6
536 myositis 9.6
537 nipples, supernumerary 9.6
538 otitis media 9.6
539 ovarian cancer 9.6
540 parkinson disease, late-onset 9.6
541 pheochromocytoma 9.6
542 polyposis, skin pigmentation, alopecia, and fingernail changes 9.6
543 prader-willi syndrome 9.6
544 keratosis, seborrheic 9.6
545 neural tube defects 9.6
546 temporal arteritis 9.6
547 thrombophilia due to thrombin defect 9.6
548 thyroid cancer, nonmedullary, 1 9.6
549 wilms tumor 1 9.6
550 acrocephalopolydactylous dysplasia 9.6
551 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 9.6
552 aspartylglucosaminuria 9.6
553 lung cancer 9.6
554 cerebellar hypoplasia 9.6
555 jalili syndrome 9.6
556 cystathioninuria 9.6
557 fanconi anemia, complementation group c 9.6
558 fryns syndrome 9.6
559 gastroschisis 9.6
560 glycogen storage disease ii 9.6
561 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.6
562 hypoascorbemia 9.6
563 immune deficiency disease 9.6
564 familial mediterranean fever 9.6
565 myxedema 9.6
566 ocular motor apraxia 9.6
567 osteogenic sarcoma 9.6
568 intrinsic factor deficiency 9.6
569 polycythemia vera 9.6
570 sjogren syndrome 9.6
571 xeroderma pigmentosum, variant type 9.6
572 opitz gbbb syndrome, type i 9.6
573 opitz-kaveggia syndrome 9.6
574 leiomyomatosis, diffuse, with alport syndrome 9.6
575 prostatic hyperplasia, benign 9.6
576 adenomyosis 9.6
577 trichothiodystrophy 1, photosensitive 9.6
578 premature aging syndrome, penttinen type 9.6
579 ossification of the posterior longitudinal ligament of spine 9.6
580 branchiootic syndrome 1 9.6
581 ovarian germ cell cancer 9.6
582 bohring-opitz syndrome 9.6
583 atrioventricular septal defect 9.6
584 allergic rhinitis 9.6
585 lissencephaly 1 9.6
586 psoriatic arthritis 9.6
587 hypertensive nephropathy 9.6
588 endometrial cancer 9.6
589 cortical dysplasia, complex, with other brain malformations 7 9.6
590 camptodactyly, tall stature, and hearing loss syndrome 9.6
591 stature quantitative trait locus 9 9.6
592 microvascular complications of diabetes 5 9.6
593 encephalocraniocutaneous lipomatosis 9.6
594 ectodermal dysplasia-syndactyly syndrome 2 9.6
595 chromosome 19p13.13 deletion syndrome 9.6
596 cholangitis, primary sclerosing 9.6
597 microcephaly-capillary malformation syndrome 9.6
598 barrett esophagus 9.6
599 graft-versus-host disease 9.6
600 cutis laxa, autosomal recessive, type ib 9.6
601 diarrhea 6 9.6
602 chromosome 3q13.31 deletion syndrome 9.6
603 cholangiocarcinoma 9.6
604 carbonic anhydrase va deficiency, hyperammonemia due to 9.6
605 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 9.6
606 mental retardation, autosomal dominant 35 9.6
607 corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia 9.6
608 helix syndrome 9.6
609 warburg-cinotti syndrome 9.6
610 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.6
611 angina pectoris 9.6
612 chronic diarrhea due to guanylate cyclase 2c overactivity 9.6
613 chlamydia pneumonia 9.6
614 bacterial sepsis 9.6
615 secretory diarrhea 9.6
616 congenital hypothyroidism 9.6
617 severe congenital neutropenia 9.6
618 congenital intrinsic factor deficiency 9.6
619 adrenal gland pheochromocytoma 9.6
620 ameloblastoma 9.6
621 lymphoma 9.6
622 familial hemiplegic migraine 9.6
623 microscopic colitis 9.6
624 ptosis 9.6
625 gallbladder disease 9.6
626 porencephaly 9.6
627 myelomeningocele 9.6
628 lymphoproliferative syndrome 9.6
629 christianson syndrome 9.6
630 isolated growth hormone deficiency 9.6
631 autosomal recessive cutis laxa type i 9.6
632 progressive familial intrahepatic cholestasis 9.6
633 digenic disease 9.6
634 large congenital melanocytic nevus 9.6
635 optic papillitis 9.6
636 pleomorphic lipoma 9.6
637 diaphragmatic eventration 9.6
638 microinvasive gastric cancer 9.6
639 osteomalacia 9.6
640 primary polycythemia 9.6
641 hypospadias 9.6
642 strongyloidiasis 9.6
643 respiratory failure 9.6
644 esophageal varix 9.6
645 t cell deficiency 9.6
646 spondyloarthropathy 9.6
647 vitamin k deficiency bleeding 9.6
648 chlamydia 9.6
649 keratomalacia 9.6
650 tetanus 9.6
651 functional diarrhea 9.6
652 heart disease 9.6
653 mitral valve insufficiency 9.6
654 suppurative otitis media 9.6
655 onchocerciasis 9.6
656 myopia 9.6
657 nephrotic syndrome 9.6
658 esophagitis 9.6
659 synostosis 9.6
660 inflammatory spondylopathy 9.6
661 oligohydramnios 9.6
662 neutropenia 9.6
663 marasmus 9.6
664 alcoholic hepatitis 9.6
665 dysentery 9.6
666 tinea pedis 9.6
667 acoustic neuroma 9.6
668 dilated cardiomyopathy 9.6
669 hyperinsulinemic hypoglycemia 9.6
670 color blindness 9.6
671 neurogenic bowel 9.6
672 kwashiorkor 9.6
673 cholestasis 9.6
674 biliary atresia 9.6
675 beriberi 9.6
676 polyneuropathy 9.6
677 squamous cell papilloma 9.6
678 amenorrhea 9.6
679 interstitial cystitis 9.6
680 small intestine lymphoma 9.6
681 chronic purulent otitis media 9.6
682 sclerosing cholangitis 9.6
683 ascending cholangitis 9.6
684 estrogen excess 9.6
685 gonadal dysgenesis 9.6
686 root resorption 9.6
687 prostatitis 9.6
688 aggressive periodontitis 9.6
689 methylmalonic acidemia 9.6
690 cholera 9.6
691 urticaria 9.6
692 cystitis 9.6
693 squamous cell carcinoma 9.6
694 pericarditis 9.6
695 viral hepatitis 9.6
696 bardet-biedl syndrome 9.6
697 cerebral palsy 9.6
698 encephalomalacia 9.6
699 dental caries 9.6
700 vulvovaginitis 9.6
701 iron metabolism disease 9.6
702 gangliocytoma 9.6
703 glomus tumor 9.6
704 acromegaly 9.6
705 retinal vascular disease 9.6
706 corneal dystrophy 9.6
707 adenomyoma 9.6
708 papilloma 9.6
709 dermoid cyst 9.6
710 cystic teratoma 9.6
711 leydig cell tumor 9.6
712 glycogen storage disease 9.6
713 contact dermatitis 9.6
714 cockayne syndrome 9.6
715 germ cell cancer 9.6
716 sertoli-leydig cell tumor 9.6
717 cystic lymphangioma 9.6
718 interstitial lung disease 9.6
719 lipid metabolism disorder 9.6
720 complex regional pain syndrome 9.6
721 embryonal rhabdomyosarcoma 9.6
722 bipolar disorder 9.6
723 fibrosarcoma 9.6
724 turner syndrome 9.6
725 ovarian gonadoblastoma 9.6
726 extramedullary plasmacytoma 9.6
727 plasmacytoma 9.6
728 vaginal discharge 9.6
729 pituitary adenoma 9.6
730 colonic pseudo-obstruction 9.6
731 thyroid gland papillary carcinoma 9.6
732 ganglioneuroblastoma 9.6
733 smooth muscle tumor 9.6
734 pustulosis of palm and sole 9.6
735 rhinitis 9.6
736 holoprosencephaly 9.6
737 intrahepatic cholangiocarcinoma 9.6
738 poliomyelitis 9.6
739 thyroid gland disease 9.6
740 ganglioglioma 9.6
741 ovarian cyst 9.6
742 plexiform neurofibroma 9.6
743 endometrial stromal tumor 9.6
744 aortitis 9.6
745 gingival hypertrophy 9.6
746 sleep disorder 9.6
747 pneumonia 9.6
748 adenosquamous breast carcinoma 9.6
749 oral submucous fibrosis 9.6
750 hemolytic anemia 9.6
751 juvenile type testicular granulosa cell tumor 9.6
752 connective tissue disease 9.6
753 overnutrition 9.6
754 spondylitis 9.6
755 juvenile rheumatoid arthritis 9.6
756 infiltrating lipoma 9.6
757 t-cell leukemia 9.6
758 thyroiditis 9.6
759 end stage renal failure 9.6
760 hyperthyroidism 9.6
761 cataract 9.6
762 osteoarthritis 9.6
763 polycythemia 9.6
764 postgastrectomy syndrome 9.6
765 ileus 9.6
766 lung disease 9.6
767 chronic fatigue syndrome 9.6
768 seborrheic dermatitis 9.6
769 lupus erythematosus 9.6
770 neuromyelitis optica 9.6
771 psoriasis 9.6
772 dermatophytosis 9.6
773 skin melanoma 9.6
774 homocystinuria 9.6
775 episodic ataxia 9.6
776 stomatitis 9.6
777 biliary tract disease 9.6
778 refractive error 9.6
779 hemophilia 9.6
780 cantú syndrome and related disorders 9.6
781 congenital disorders of n-linked glycosylation and multiple pathway 9.6
782 efemp2-related cutis laxa 9.6
783 fgfr-related craniosynostosis syndromes 9.6
784 heritable thoracic aortic disease 9.6
785 isolated methylmalonic acidemia 9.6
786 med12-related disorders 9.6
787 ppp2r5d-related neurodevelopmental disorder 9.6
788 candida glabrata 9.6
789 cavernous lymphangioma 9.6
790 chromosome 17q11.2 deletion syndrome 9.6
791 congenital femoral deficiency 9.6
792 encephalocele 9.6
793 exfoliative dermatitis 9.6
794 facial infiltrating lipomatosis 9.6
795 fibro-adipose vascular anomaly 9.6
796 germ cells tumors 9.6
797 hemiplegic migraine 9.6
798 leukoplakia 9.6
799 lymphangiomatosis 9.6
800 lymphosarcoma 9.6
801 neuromyelitis optica spectrum disorder 9.6
802 oral cancer 9.6
803 ring chromosome 4 9.6
804 sacrococcygeal teratoma 9.6
805 windblown hand 9.6
806 19p13.13 deletion syndrome 9.6
807 central precocious puberty 9.6
808 color vision deficiency 9.6
809 multiple endocrine neoplasia 9.6
810 autonomic dysfunction 9.6
811 brain injury 9.6
812 hypertonia 9.6
813 spasticity 9.6
814 traumatic brain injury 9.6
815 tremor 9.6
816 progeroid syndrome 9.6
817 segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome 9.6
818 rapidly involuting congenital hemangioma 9.6
819 hemimelia 9.6
820 obsolete: atypical teratoid/rhabdoid tumor 9.6
821 uniparental disomy of chromosome 7 9.6
822 isolated megalencephaly 9.6
823 zimmermann-laband syndrome 9.6
824 rare lymphatic malformation 9.6
825 adenosarcoma of the cervix uteri 9.6
826 pouchitis 9.6
827 semilobar holoprosencephaly 9.6
828 inverse klippel-trenaunay syndrome 9.6
829 ring chromosome 9.6
830 congenital pseudoarthrosis of the tibia 9.6
831 familial intrahepatic cholestasis 9.6
832 growing teratoma syndrome 9.6
833 ovarian fibroma 9.6
834 refractory celiac disease 9.6
835 avascular necrosis 9.6
836 rasopathy 9.6
837 rare surgical neurologic disease 9.6
838 intestinal polyposis syndrome 9.6
839 thyroid carcinoma 9.6

Graphical network of the top 20 diseases related to Overgrowth Syndrome:



Diseases related to Overgrowth Syndrome

Symptoms & Phenotypes for Overgrowth Syndrome

MGI Mouse Phenotypes related to Overgrowth Syndrome:

45 (showing 6, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.06 APC2 DIS3L2 DNMT3A GPC3 IGF2 NFIX
2 craniofacial MP:0005382 9.91 GPC3 IGF2 NFIX NPPC NPR2 PDGFRB
3 nervous system MP:0003631 9.85 APC2 DNMT3A IGF2 KCNK4 NFIX NPPC
4 limbs/digits/tail MP:0005371 9.73 GPC3 IGF2 NPPC NPR2 PDGFRB SETD2
5 reproductive system MP:0005389 9.56 APC2 DNMT3A GPC3 IGF2 NPPC NPR2
6 skeleton MP:0005390 9.32 DIS3L2 DNMT3A GPC3 IGF2 NFIX NPPC

Drugs & Therapeutics for Overgrowth Syndrome

Drugs for Overgrowth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 304, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Ethanol Approved Phase 4 64-17-5 702
3
Lubiprostone Approved, Investigational Phase 4 136790-76-6 656719
4
Octreotide Approved, Investigational Phase 4 83150-76-9 6400441 383414
5
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
6
Olodaterol Approved Phase 4 868049-49-4
7
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
8
Lactulose Approved Phase 4 4618-18-2 11333
9 Fluoroquinolones Phase 4
10 Clindamycin palmitate Phase 4
11 Clindamycin phosphate Phase 4
12 Cola Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14 Neurotransmitter Agents Phase 4
15 Cholinergic Agents Phase 4
16 Bromides Phase 4
17 Amoxicillin-Potassium Clavulanate Combination Phase 4
18 beta-Lactamase Inhibitors Phase 4
19 Anti-Inflammatory Agents Phase 4
20 Respiratory System Agents Phase 4
21 Anti-Asthmatic Agents Phase 4
22 Autonomic Agents Phase 4
23 Bronchodilator Agents Phase 4
24 Tiotropium Bromide Phase 4 136310-93-5
25 Parasympatholytics Phase 4
26 Cholinergic Antagonists Phase 4
27 Anti-Allergic Agents Phase 4
28
Propranolol Approved, Investigational Phase 3 525-66-6 4946
29
Sodium citrate Approved, Investigational Phase 3 68-04-2
30
leucovorin Approved Phase 3 58-05-9 6006 143
31
Phenytoin Approved, Vet_approved Phase 3 57-41-0 1775
32
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
33
Norfloxacin Approved Phase 3 70458-96-7 4539
34
Tobramycin Approved, Investigational Phase 3 32986-56-4 36294 5496
35
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
36
Stavudine Approved, Investigational Phase 3 3056-17-5 18283
37
Glycerol Approved, Investigational Phase 3 56-81-5 753
38
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
39
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
40
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
41
Metronidazole Approved Phase 3 443-48-1 4173
42
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
43
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
44
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
45
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
46
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
47
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
48
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
49
Lactitol Investigational Phase 3 585-88-6, 585-86-4 493591
50 Gastrointestinal Agents Phase 3
51 Vasodilator Agents Phase 3
52 Anti-Arrhythmia Agents Phase 3
53 Antihypertensive Agents Phase 3
54 Adrenergic Antagonists Phase 3
55 Adrenergic beta-Antagonists Phase 3
56 Adrenergic Agents Phase 3
57 Citrate Phase 3
58 Vitamin B Complex Phase 3
59 Vitamin B9 Phase 3
60 Sodium Channel Blockers Phase 3
61 Anticonvulsants Phase 3
62 Folate Phase 3
63 Diuretics, Potassium Sparing Phase 3
64 Albumin-Bound Paclitaxel Phase 3
65 Nonoxynol Phase 2, Phase 3
66 Contraceptive Agents Phase 2, Phase 3
67 Spermatocidal Agents Phase 2, Phase 3
68 Ophthalmic Solutions Phase 3
69 Acidophilus Phase 3
70 Antimitotic Agents Phase 3
71
Liposomal doxorubicin Phase 3 31703
72 Antiprotozoal Agents Phase 3
73 Antiparasitic Agents Phase 3
74 Antitubercular Agents Phase 3
75 Gentamicins Phase 3
76 Cephalosporins Phase 3
77 penicillins Phase 3
78 Penicillin G Benzathine Phase 3
79 Penicillin G Procaine Phase 3
80 Pharmaceutical Solutions Phase 2, Phase 3
81
Povidone Approved Phase 2 9003-39-8
82
Povidone-iodine Approved Phase 2 25655-41-8
83
Iodine Approved, Investigational Phase 2 7553-56-2 807
84
Benzoyl peroxide Approved Phase 2 94-36-0 7187
85
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
86
Azithromycin Approved Phase 2 83905-01-5 447043 55185
87
lanreotide Approved Phase 2 108736-35-2
88
Gemcitabine Approved Phase 2 95058-81-4 60750
89
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
90
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
91
Rilonacept Approved, Investigational Phase 1, Phase 2 501081-76-1 104924
92
Milk thistle Approved, Experimental, Investigational Phase 1, Phase 2 65666-07-1
93 Clove Approved Phase 1, Phase 2
94
Wormwood Approved, Experimental Phase 1, Phase 2
95 Artichoke Approved Phase 1, Phase 2
96
Turmeric Approved, Experimental, Investigational Phase 1, Phase 2
97
Ustekinumab Approved, Investigational Phase 1, Phase 2 815610-63-0
98
Methionine Approved, Nutraceutical Phase 1, Phase 2 63-68-3 6137
99
Betaine Approved, Nutraceutical Phase 1, Phase 2 107-43-7 247
100
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750