MCID: OVR082
MIFTS: 50

Overgrowth Syndrome

Categories: Cardiovascular diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Overgrowth Syndrome

MalaCards integrated aliases for Overgrowth Syndrome:

Name: Overgrowth Syndrome 58 29
Overgrowth 29 6

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q87.3
Orphanet 58 ORPHA93460

Summaries for Overgrowth Syndrome

MalaCards based summary : Overgrowth Syndrome, also known as overgrowth, is related to facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome and epiphyseal chondrodysplasia, miura type. An important gene associated with Overgrowth Syndrome is NSD1 (Nuclear Receptor Binding SET Domain Protein 1), and among its related pathways/superpathways are MicroRNAs in cancer and Pathways Affected in Adenoid Cystic Carcinoma. The drugs Clindamycin and Lubiprostone have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Overgrowth Syndrome

Diseases in the Overgrowth Syndrome family:

Eed-Related Overgrowth Ezh2-Related Overgrowth
Pik3ca-Related Overgrowth Spectrum Pik3ca-Related Overgrowth Syndrome

Diseases related to Overgrowth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 854, show less)
# Related Disease Score Top Affiliating Genes
1 facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome 34.1 KCNK4-TEX40 KCNK4
2 epiphyseal chondrodysplasia, miura type 31.9 NPR2 NPPC
3 weaver syndrome 31.7 SETD2 NSD1 NFIX GPC3 DNMT3A DIS3L2
4 beckwith-wiedemann syndrome 31.3 NSD1 IGF2 H19-ICR GPC3 DNMT3A
5 sotos syndrome 1 31.1 SETD2 NSD1 NFIX GPC3 DNMT3A CHD8
6 macrodactyly 30.2 PIK3CA NPR2
7 marshall-smith syndrome 30.0 NSD1 NFIX
8 wilms tumor predisposition 28.7 NSD1 IGF2 H19-ICR GPC3 DIS3L2
9 leukemia, acute myeloid 28.6 SETD2 PIK3CA PDGFRB NSD1 DNMT3A
10 kosaki overgrowth syndrome 12.6
11 capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth 12.6
12 global developmental delay, lung cysts, overgrowth, and wilms tumor 12.5
13 gingival overgrowth 12.4
14 dnmt3a overgrowth syndrome 12.4
15 acromegaloid features, overgrowth, cleft palate, and hernia 12.3
16 overgrowth-macrocephaly-facial dysmorphism syndrome 12.3
17 metaphyseal undermodeling, spondylar dysplasia, and overgrowth 12.3
18 vertebral body fusion overgrowth 12.3
19 pik3ca-related overgrowth syndrome 12.2
20 eed-related overgrowth 12.2
21 segmental progressive overgrowth syndrome with fibroadipose hyperplasia 12.1
22 overgrowth syndrome with 2q37 translocation 12.1
23 genetic overgrowth/obesity syndrome 12.1
24 overgrowth/obesity syndrome 12.1
25 non syndromic limb overgrowth 12.1
26 overgrowth or tall stature syndrome with skeletal involvement 12.1
27 chromosomal disease with overgrowth 12.1
28 tatton-brown-rahman syndrome 12.0
29 simpson-golabi-behmel syndrome 11.9
30 sotos syndrome 2 11.7
31 macrocephaly, dysmorphic facies, and psychomotor retardation 11.7
32 rahman syndrome 11.6
33 fibromatosis, gingival, 1 11.6
34 blind loop syndrome 11.5
35 proteus syndrome 11.5
36 sclerosteosis 11.5
37 perlman syndrome 11.5
38 megalencephaly-capillary malformation-polymicrogyria syndrome 11.5
39 nevus, epidermal 11.4
40 capillary malformation-arteriovenous malformation 1 11.4
41 loeys-dietz syndrome 5 11.4
42 developmental delay with variable intellectual impairment and behavioral abnormalities 11.4
43 imagawa-matsumoto syndrome 11.4
44 facial infiltrating lipomatosis 11.4
45 simpson-golabi-behmel syndrome, type 1 11.4
46 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 11.4
47 hemihyperplasia, isolated 11.3
48 momo syndrome 11.3
49 tenorio syndrome 11.3
50 pyogenic granuloma 11.3
51 fibromatosis 11.3
52 gingival fibromatosis 11.3
53 tuberous sclerosis 1 11.3
54 ossifying fibroma 11.3
55 costello syndrome 11.3
56 keloid disorder 11.3
57 breast malignant phyllodes tumor 11.3
58 corneal dystrophy, posterior polymorphous, 1 11.3
59 mucolipidosis ii alpha/beta 11.3
60 chromosome xq26.3 duplication syndrome 11.3
61 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 11.3
62 sclerosteosis 2 11.3
63 clostridium difficile colitis 11.3
64 familial isolated pituitary adenoma 11.3
65 inflammatory linear verrucous epidermal nevus 11.3
66 post-transplant lymphoproliferative disease 11.3
67 proteus-like syndrome 11.3
68 craniometaphyseal dysplasia, autosomal dominant 11.2
69 laryngoonychocutaneous syndrome 11.2
70 ehlers-danlos syndrome, kyphoscoliotic type, 1 11.2
71 tetrasomy 15q26 11.1
72 barnicoat baraitser syndrome 11.1
73 hairy tongue 11.1
74 richieri-costa guion-almeida cohen syndrome 11.1
75 hyperostosis cranialis interna 11.1
76 amelogenesis imperfecta, type ig 11.1
77 van buchem disease 11.1
78 pleuropulmonary blastoma 11.1
79 histiocytosis-lymphadenopathy plus syndrome 11.1
80 rippling muscle disease 2 11.1
81 fibromatosis, gingival, 5 11.1
82 intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures 11.1
83 beck-fahrner syndrome 11.1
84 x-linked congenital generalized hypertrichosis 11.1
85 hypertrichosis, congenital generalized, with or without gingival hyperplasia 11.0
86 cowden syndrome 1 11.0
87 silver-russell syndrome 1 11.0
88 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 11.0
89 thauvin-robinet-faivre syndrome 11.0
90 sotos syndrome 3 11.0
91 hemi 3 syndrome 11.0
92 cherubism 10.9
93 beare-stevenson cutis gyrata syndrome 10.9
94 fibromatosis, gingival, with progressive deafness 10.9
95 gastritis, familial giant hypertrophic 10.9
96 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.9
97 beukes hip dysplasia 10.9
98 chromosome 8q22.1 duplication syndrome 10.9
99 schimmelpenning-feuerstein-mims syndrome 10.9
100 polycystic liver disease 1 with or without kidney cysts 10.9
101 uterine anomalies 10.9
102 white sponge nevus 1 10.9
103 craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome 10.9
104 craniometaphyseal dysplasia, autosomal recessive 10.9
105 acth-independent macronodular adrenal hyperplasia 10.9
106 hyaline fibromatosis syndrome 10.9
107 multicentric osteolysis, nodulosis, and arthropathy 10.9
108 sclerosteosis 1 10.9
109 winchester syndrome 10.9
110 simpson-golabi-behmel syndrome, type 2 10.9
111 brachydactyly, mononen type 10.9
112 trimethylaminuria 10.9
113 alpha-thalassemia 10.9
114 becker nevus syndrome 10.9
115 lymphangioleiomyomatosis 10.9
116 gastrointestinal stromal tumor 10.9
117 cinca syndrome 10.9
118 leukemia, chronic myeloid 10.9
119 fibromatosis, gingival, 4 10.9
120 acute promyelocytic leukemia 10.9
121 tuberous sclerosis 2 10.9
122 mitochondrial dna depletion syndrome 4b 10.9
123 polycystic liver disease 2 with or without kidney cysts 10.9
124 polycystic liver disease 3 with or without kidney cysts 10.9
125 polycystic liver disease 4 with or without kidney cysts 10.9
126 congenital generalized lipodystrophy 10.9
127 robinow syndrome 10.9
128 hennekam syndrome 10.9
129 baritosis 10.9
130 chronic mucocutaneous candidiasis 10.9
131 pigmented villonodular synovitis 10.9
132 tenosynovial giant cell tumor 10.9
133 glycoproteinosis 10.9
134 pelvic lipomatosis 10.9
135 diffuse idiopathic skeletal hyperostosis 10.9
136 limb-girdle muscular dystrophy 10.9
137 cutaneous-skeletal hypophosphatemia syndrome 10.9
138 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 10.9
139 intravascular papillary endothelial hyperplasia 10.9
140 juvenile ossifying fibroma 10.9
141 macrodactyly of fingers 10.9
142 ogilvie syndrome 10.9
143 osteochondroma 10.9
144 pseudoangiomatous stromal hyperplasia 10.9
145 rokitansky-aschoff sinuses of the gallbladder 10.9
146 cav3-related distal myopathy 10.9
147 recombinant 8 syndrome 10.9
148 irritable bowel syndrome 10.7
149 adenosarcoma 10.5
150 gingivitis 10.4
151 periodontitis 10.3
152 cornelia de lange syndrome 5 10.3 NSD1 NFIX
153 liver disease 10.3
154 gestational diabetes 10.2
155 fatty liver disease 10.2
156 alacrima, achalasia, and mental retardation syndrome 10.2
157 peritonitis 10.2
158 fibroma 10.2
159 non-alcoholic steatohepatitis 10.2
160 sarcomatous intrahepatic cholangiocarcinoma 10.2 PDGFRB GPC3
161 scoliosis 10.2
162 non-alcoholic fatty liver disease 10.2
163 short bowel syndrome 10.2
164 adenosarcoma of the uterus 10.2
165 pax6-related aniridia 10.2 IGF2 GPC3
166 cystic fibrosis 10.2
167 periodontitis, chronic 10.2
168 lactose intolerance 10.2
169 scleroderma, familial progressive 10.1
170 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
171 gastritis 10.1
172 pancreatitis 10.1
173 beckwith-wiedemann syndrome due to 11p15 microdeletion 10.1
174 beckwith-wiedemann syndrome due to 11p15 translocation/inversion 10.1
175 beckwith-wiedemann syndrome due to imprinting defect of 11p15 10.1
176 beckwith-wiedemann syndrome due to paternal uniparental disomy of chromosome 11 10.1
177 beckwith-wiedemann syndrome due to 11p15 microduplication 10.1
178 frontal convexity meningioma 10.1 PIK3CA PDGFRB
179 hepatic coma 10.1
180 hepatic encephalopathy 10.1
181 intestinal disease 10.1
182 klippel-trenaunay-weber syndrome 10.1
183 diarrhea 10.1
184 scoliosis, isolated 1 10.1
185 helicobacter pylori infection 10.1
186 idiopathic scoliosis 10.1
187 hypothyroidism 10.1
188 peptic ulcer disease 10.1
189 hydrocephalus 10.1
190 neuropathy, hereditary sensory, type ie 10.1 NSD1 DNMT3A
191 hair whorl 10.1
192 ankylosis 10.1
193 endometriosis 10.1
194 hyperglycemia 10.1
195 learning disability 10.1
196 gigantism 10.1
197 pectus excavatum 10.0
198 methane production 10.0
199 hyperinsulinism 10.0
200 dermatitis 10.0
201 rosacea 10.0
202 atrophic gastritis 10.0
203 encephalopathy 10.0
204 paraphimosis 10.0 NPR2 NPPC
205 achondroplasia 10.0
206 autoimmune disease 10.0
207 gastroesophageal reflux 10.0
208 cryptorchidism, unilateral or bilateral 10.0
209 insulin-like growth factor i 10.0
210 leptin deficiency or dysfunction 10.0
211 oral squamous cell carcinoma 10.0
212 immunoglobulin alpha deficiency 10.0
213 rhabdomyosarcoma 10.0
214 epulis 10.0
215 hemimegalencephaly 10.0
216 chromosome 2q35 duplication syndrome 10.0
217 macrocephaly/megalencephaly syndrome, autosomal recessive 10.0
218 wilms tumor 5 10.0
219 craniosynostosis 10.0
220 neurofibromatosis 10.0
221 hypoglycemia 10.0
222 ezh2-related overgrowth 10.0
223 weber syndrome 10.0
224 megalencephaly 10.0
225 camptodactyly-tall stature-scoliosis-hearing loss syndrome 10.0 NPR2 NPPC
226 colorectal cancer 9.9
227 strabismus 9.9
228 varicose veins 9.9
229 proteasome-associated autoinflammatory syndrome 1 9.9
230 gonadoblastoma 9.9
231 gallbladder disease 1 9.9
232 dermatitis, atopic 9.9
233 fatty liver disease, nonalcoholic 1 9.9
234 vitamin b12 deficiency 9.9
235 colitis 9.9
236 cervical polyp 9.9
237 bacterial infectious disease 9.9
238 amelogenesis imperfecta 9.9
239 gastroenteritis 9.9
240 macrocytic anemia 9.9
241 cervical adenosarcoma 9.9
242 vaginal adenosarcoma 9.9
243 hypertrichosis 9.9
244 duodenitis 9.9
245 mechanical strabismus 9.9
246 congenital amputation 9.9
247 dysphagia 9.9
248 autism 9.9
249 polydactyly 9.9
250 autism spectrum disorder 9.9
251 umbilical hernia 9.9
252 infantile myofibromatosis 9.9
253 lipomatosis 9.9
254 chromosomal triplication 9.9
255 arteries, anomalies of 9.9
256 enterocolitis 9.9
257 hypomelanosis of ito 9.9
258 ataxia and polyneuropathy, adult-onset 9.9
259 body mass index quantitative trait locus 1 9.9
260 gastric cancer 9.9
261 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
262 hyperlipoproteinemia, type iii 9.9
263 lipoprotein quantitative trait locus 9.9
264 thrombosis 9.9
265 bone disease 9.9
266 monocular esotropia 9.9
267 glucose intolerance 9.9
268 gastric ulcer 9.9
269 prostatic hypertrophy 9.9
270 plica syndrome 9.9
271 leiomyoma 9.9
272 obstructive hydrocephalus 9.9
273 dumping syndrome 9.9
274 gingival disease 9.9
275 keratosis 9.9
276 benign breast phyllodes tumor 9.9
277 duodenal ulcer 9.9
278 mitral valve stenosis 9.9
279 synovitis 9.9
280 prostatic adenoma 9.9
281 mammary paget's disease 9.9
282 polyhydramnios 9.9
283 diabetes mellitus 9.9
284 cholangitis 9.9
285 esotropia 9.9
286 cytokine deficiency 9.9
287 dwarfism 9.9
288 fetal macrosomia 9.9
289 lymphangiectasis 9.9
290 temporomandibular ankylosis 9.9
291 abdominal wall defect 9.9
292 renal dysplasia 9.9
293 rare tumor 9.9
294 macroglossia 9.8
295 dowling-degos disease 1 9.8
296 wolf-hirschhorn syndrome 9.8
297 hydrocephalus, congenital, 1 9.8
298 congenital short bowel syndrome 9.8
299 polymicrogyria with or without vascular-type ehlers-danlos syndrome 9.8
300 deficiency anemia 9.8
301 pulmonary hypertension 9.8
302 loeys-dietz syndrome 9.8
303 inflammatory bowel disease 9.8
304 basal ganglia calcification 9.8
305 hyperostosis 9.8
306 constipation 9.8
307 myofibroma 9.8
308 cowden syndrome 9.8
309 hepatoblastoma 9.8
310 neuroblastoma 9.8
311 intestinal obstruction 9.8
312 ulcerative colitis 9.8
313 myeloid leukemia 9.8
314 crohn's disease 9.8
315 pik3ca-related segmental overgrowth 9.8
316 polymicrogyria 9.8
317 pik3ca-related overgrowth spectrum 9.8
318 slipped capital femoral epiphysis 9.8
319 9q22.3 microdeletion 9.8
320 hypotonia 9.8
321 premature aging 9.8
322 multiple congenital anomalies/dysmorphic syndrome-intellectual disability 9.8
323 acromesomelic dysplasia, maroteaux type 9.8 NPR2 NPPC DIS3L2
324 acanthosis nigricans 9.8
325 atherosclerosis susceptibility 9.8
326 breast cancer 9.8
327 hepatocellular carcinoma 9.8
328 coxa vara 9.8
329 multiple sclerosis 9.8
330 esophageal cancer 9.8
331 fibrosis of extraocular muscles, congenital, 1 9.8
332 hand skill, relative 9.8
333 developmental dysplasia of the hip 1 9.8
334 legg-calve-perthes disease 9.8
335 lipomatosis, multiple 9.8
336 melanoma, uveal 9.8
337 retinoblastoma 9.8
338 rheumatoid arthritis 9.8
339 triiodothyronine receptor auxiliary protein 9.8
340 gastroschisis 9.8
341 osteoid osteoma 9.8
342 pancreatic cancer 9.8
343 thymoma, familial 9.8
344 yemenite deaf-blind hypopigmentation syndrome 9.8
345 bone mineral density quantitative trait locus 3 9.8
346 melanoma, cutaneous malignant 10 9.8
347 restless legs syndrome 9.8
348 autosomal recessive disease 9.8
349 pervasive developmental disorder 9.8
350 ileitis 9.8
351 ileocolitis 9.8
352 inguinal hernia 9.8
353 sensorineural hearing loss 9.8
354 endocarditis 9.8
355 pre-eclampsia 9.8
356 tropical sprue 9.8
357 portal hypertension 9.8
358 alport syndrome 9.8
359 functional diarrhea 9.8
360 clubfoot 9.8
361 hypertrophic cardiomyopathy 9.8
362 allergic hypersensitivity disease 9.8
363 primary biliary cirrhosis 9.8
364 exocrine pancreatic insufficiency 9.8
365 ehlers-danlos syndrome 9.8
366 megaloblastic anemia 9.8
367 candidiasis 9.8
368 alcohol use disorder 9.8
369 melanoma 9.8
370 hypogonadism 9.8
371 exostosis 9.8
372 neonatal jaundice 9.8
373 ovarian brenner tumor 9.8
374 bilirubin metabolic disorder 9.8
375 glycogen storage disease 9.8
376 acute pancreatitis 9.8
377 adenocarcinoma 9.8
378 cutis laxa 9.8
379 neurilemmoma 9.8
380 lysosomal storage disease 9.8
381 thymoma 9.8
382 teratoma 9.8
383 mesenchymal cell neoplasm 9.8
384 breast adenocarcinoma 9.8
385 arthropathy 9.8
386 myopathy 9.8
387 carcinosarcoma 9.8
388 dysgerminoma 9.8
389 holoprosencephaly 9.8
390 familial retinoblastoma 9.8
391 leiomyomatosis 9.8
392 sleep disorder 9.8
393 mature teratoma 9.8
394 kidney disease 9.8
395 intravenous leiomyomatosis 9.8
396 peripheral nervous system disease 9.8
397 uterine carcinosarcoma 9.8
398 fibromyalgia 9.8
399 adenoma 9.8
400 diverticulitis 9.8
401 arthritis 9.8
402 perinatal necrotizing enterocolitis 9.8
403 pulmonary embolism 9.8
404 neurofibroma 9.8
405 hypereosinophilic syndrome 9.8
406 47,xyy 9.8
407 48,xyyy 9.8
408 chiari malformation 9.8
409 diencephalic syndrome 9.8
410 exencephaly 9.8
411 pectus carinatum 9.8
412 precocious puberty 9.8
413 uterine sarcoma 9.8
414 hypoxia 9.8
415 spinal cord injury 9.8
416 mosaic trisomy 12 9.8
417 acute liver failure 9.8
418 paternal uniparental disomy 9.8
419 basal cell nevus syndrome 9.7
420 carpal tunnel syndrome 9.7
421 cleft palate, isolated 9.7
422 coloboma of macula 9.7
423 diaphragmatic hernia, congenital 9.7
424 attention deficit-hyperactivity disorder 9.7
425 hypertelorism 9.7
426 marfan syndrome 9.7
427 meckel diverticulum 9.7
428 neurofibromatosis, type i 9.7
429 obsessive-compulsive disorder 9.7
430 sturge-weber syndrome 9.7
431 renal hypodysplasia/aplasia 1 9.7
432 arachnoid cysts, intracranial 9.7
433 celiac disease 1 9.7
434 cutis marmorata telangiectatica congenita 9.7
435 dandy-walker syndrome 9.7
436 fanconi anemia, complementation group c 9.7
437 peho syndrome 9.7
438 body mass index quantitative trait locus 11 9.7
439 fragile x syndrome 9.7
440 pallister-killian syndrome 9.7
441 body mass index quantitative trait locus 9 9.7
442 body mass index quantitative trait locus 8 9.7
443 macrocephaly/autism syndrome 9.7
444 body mass index quantitative trait locus 4 9.7
445 body mass index quantitative trait locus 10 9.7
446 body mass index quantitative trait locus 7 9.7
447 body mass index quantitative trait locus 12 9.7
448 body mass index quantitative trait locus 14 9.7
449 chromosome 17q11.2 deletion syndrome, 1.4-mb 9.7
450 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.7
451 body mass index quantitative trait locus 18 9.7
452 acid-labile subunit deficiency 9.7
453 luscan-lumish syndrome 9.7
454 cohen-gibson syndrome 9.7
455 alkuraya-kucinskas syndrome 9.7
456 body mass index quantitative trait locus 19 9.7
457 body mass index quantitative trait locus 20 9.7
458 angiosarcoma 9.7
459 distal arthrogryposis 9.7
460 sleep apnea 9.7
461 apraxia 9.7
462 crohn's colitis 9.7
463 omphalocele 9.7
464 fibrous dysplasia 9.7
465 acromesomelic dysplasia 9.7
466 intestinal pseudo-obstruction 9.7
467 polycystic kidney disease 9.7
468 protein-losing enteropathy 9.7
469 microcephaly 9.7
470 hydronephrosis 9.7
471 arteriovenous malformation 9.7
472 megacolon 9.7
473 autonomic neuropathy 9.7
474 dysgammaglobulinemia 9.7
475 visual epilepsy 9.7
476 gastroparesis 9.7
477 chagas disease 9.7
478 leukemia 9.7
479 acute leukemia 9.7
480 tuberous sclerosis 9.7
481 lymphangioma 9.7
482 ectropion 9.7
483 ventricular septal defect 9.7
484 heart septal defect 9.7
485 vascular disease 9.7
486 epilepsy 9.7
487 leiomyosarcoma 9.7
488 basal cell carcinoma 9.7
489 hemangioma 9.7
490 benign mesothelioma 9.7
491 cellulitis 9.7
492 skin disease 9.7
493 systemic scleroderma 9.7
494 pyoderma 9.7
495 spongiotic dermatitis 9.7
496 pleomorphic adenoma 9.7
497 liver cirrhosis 9.7
498 congestive heart failure 9.7
499 skin tag 9.7
500 gastrointestinal system disease 9.7
501 neuropathy 9.7
502 pathologic nystagmus 9.7
503 postcholecystectomy syndrome 9.7
504 alopecia 9.7
505 muscular dystrophy 9.7
506 mixed phenotype acute leukemia 9.7
507 bap1 tumor predisposition syndrome 9.7
508 hypermobile ehlers-danlos syndrome 9.7
509 antisynthetase syndrome 9.7
510 chromosome 15q duplication 9.7
511 chromosome 4p deletion 9.7
512 glioma 9.7
513 horseshoe kidney 9.7
514 parkes weber syndrome 9.7
515 retinochoroidal coloboma 9.7
516 splenomegaly 9.7
517 seizure disorder 9.7
518 angioosteohypertrophic syndrome 9.7
519 glial tumor 9.7
520 hemihyperplasia-multiple lipomatosis syndrome 9.7
521 lower limb hypertrophy 9.7
522 congenital amyoplasia 9.7
523 rare vascular disease 9.7
524 acroosteolysis 9.6
525 alcohol dependence 9.6
526 spondyloarthropathy 1 9.6
527 episodic ataxia, type 2 9.6
528 aortic valve disease 1 9.6
529 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.6
530 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 9.6
531 colchicine resistance 9.6
532 cone-rod dystrophy 2 9.6
533 dysplasia epiphysealis hemimelica 9.6
534 ehlers-danlos syndrome, classic type, 1 9.6
535 hemifacial hyperplasia 9.6
536 hashimoto thyroiditis 9.6
537 hirschsprung disease 1 9.6
538 hypercholesterolemia, familial, 1 9.6
539 renal cell carcinoma, nonpapillary 9.6
540 hypochondroplasia 9.6
541 keloid formation 9.6
542 kleine-levin hibernation syndrome 9.6
543 leiomyoma, uterine 9.6
544 systemic lupus erythematosus 9.6
545 treacher collins syndrome 1 9.6
546 medulloblastoma 9.6
547 mesothelioma, malignant 9.6
548 migraine with or without aura 1 9.6
549 myositis 9.6
550 nipples, supernumerary 9.6
551 otitis media 9.6
552 ovarian cancer 9.6
553 parkinson disease, late-onset 9.6
554 pheochromocytoma 9.6
555 polyposis, skin pigmentation, alopecia, and fingernail changes 9.6
556 prader-willi syndrome 9.6
557 keratosis, seborrheic 9.6
558 neural tube defects 9.6
559 telecanthus 9.6
560 temporal arteritis 9.6
561 thanatophoric dysplasia, type i 9.6
562 thrombophilia due to thrombin defect 9.6
563 thyroid cancer, nonmedullary, 1 9.6
564 wilms tumor 1 9.6
565 acrocephalopolydactylous dysplasia 9.6
566 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 9.6
567 aspartylglucosaminuria 9.6
568 lung cancer 9.6
569 jalili syndrome 9.6
570 cystathioninuria 9.6
571 fryns syndrome 9.6
572 glycogen storage disease ii 9.6
573 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.6
574 hypoascorbemia 9.6
575 immune deficiency disease 9.6
576 familial mediterranean fever 9.6
577 myxedema 9.6
578 ocular motor apraxia 9.6
579 osteogenic sarcoma 9.6
580 intrinsic factor deficiency 9.6
581 polycythemia vera 9.6
582 sjogren syndrome 9.6
583 xeroderma pigmentosum, variant type 9.6
584 opitz gbbb syndrome, type i 9.6
585 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 9.6
586 opitz-kaveggia syndrome 9.6
587 leiomyomatosis, diffuse, with alport syndrome 9.6
588 rett syndrome 9.6
589 prostatic hyperplasia, benign 9.6
590 adenomyosis 9.6
591 premature aging syndrome, penttinen type 9.6
592 ossification of the posterior longitudinal ligament of spine 9.6
593 branchiootic syndrome 1 9.6
594 ovarian germ cell cancer 9.6
595 bohring-opitz syndrome 9.6
596 atrioventricular septal defect 9.6
597 allergic rhinitis 9.6
598 coronary heart disease 1 9.6
599 lissencephaly 1 9.6
600 psoriatic arthritis 9.6
601 hypertensive nephropathy 9.6
602 endometrial cancer 9.6
603 camptodactyly, tall stature, and hearing loss syndrome 9.6
604 stature quantitative trait locus 9 9.6
605 microvascular complications of diabetes 5 9.6
606 encephalocraniocutaneous lipomatosis 9.6
607 ectodermal dysplasia-syndactyly syndrome 2 9.6
608 chromosome 19p13.13 deletion syndrome 9.6
609 cholangitis, primary sclerosing 9.6
610 microcephaly-capillary malformation syndrome 9.6
611 barrett esophagus 9.6
612 graft-versus-host disease 9.6
613 cutis laxa, autosomal recessive, type ib 9.6
614 diarrhea 6 9.6
615 chromosome 3q13.31 deletion syndrome 9.6
616 cholangiocarcinoma 9.6
617 carbonic anhydrase va deficiency, hyperammonemia due to 9.6
618 megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 9.6
619 mental retardation, autosomal dominant 35 9.6
620 corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia 9.6
621 joint laxity, short stature, and myopia 9.6
622 helix syndrome 9.6
623 warburg-cinotti syndrome 9.6
624 cortical dysplasia, complex, with other brain malformations 10 9.6
625 juvenile arthritis 9.6
626 angina pectoris 9.6
627 chronic diarrhea due to guanylate cyclase 2c overactivity 9.6
628 chlamydia pneumonia 9.6
629 bacterial sepsis 9.6
630 secretory diarrhea 9.6
631 congenital hypothyroidism 9.6
632 severe congenital neutropenia 9.6
633 congenital intrinsic factor deficiency 9.6
634 adrenal gland pheochromocytoma 9.6
635 ameloblastoma 9.6
636 lymphoma 9.6
637 familial hemiplegic migraine 9.6
638 microscopic colitis 9.6
639 ptosis 9.6
640 gallbladder disease 9.6
641 porencephaly 9.6
642 myelomeningocele 9.6
643 chromosome 17q11.2 deletion syndrome 9.6
644 lymphoproliferative syndrome 9.6
645 christianson syndrome 9.6
646 isolated growth hormone deficiency 9.6
647 autosomal recessive cutis laxa type i 9.6
648 progressive familial intrahepatic cholestasis 9.6
649 childhood acute myeloid leukemia 9.6
650 cerebellar hypoplasia 9.6
651 digenic disease 9.6
652 benign teratoma 9.6
653 rasopathy 9.6
654 large congenital melanocytic nevus 9.6
655 optic papillitis 9.6
656 pleomorphic lipoma 9.6
657 diaphragmatic eventration 9.6
658 microinvasive gastric cancer 9.6
659 osteomalacia 9.6
660 primary polycythemia 9.6
661 hypospadias 9.6
662 strongyloidiasis 9.6
663 brucellosis 9.6
664 sarcoma 9.6
665 respiratory failure 9.6
666 esophageal varix 9.6
667 t cell deficiency 9.6
668 spondyloarthropathy 9.6
669 vitamin k deficiency bleeding 9.6
670 chlamydia 9.6
671 keratomalacia 9.6
672 tetanus 9.6
673 heart disease 9.6
674 mitral valve insufficiency 9.6
675 suppurative otitis media 9.6
676 onchocerciasis 9.6
677 myopia 9.6
678 nephrotic syndrome 9.6
679 esophagitis 9.6
680 synostosis 9.6
681 inflammatory spondylopathy 9.6
682 common variable immunodeficiency 9.6
683 oligohydramnios 9.6
684 neutropenia 9.6
685 marasmus 9.6
686 alcoholic hepatitis 9.6
687 dysentery 9.6
688 tinea pedis 9.6
689 acoustic neuroma 9.6
690 dilated cardiomyopathy 9.6
691 hyperinsulinemic hypoglycemia 9.6
692 color blindness 9.6
693 neurogenic bowel 9.6
694 kwashiorkor 9.6
695 cholestasis 9.6
696 biliary atresia 9.6
697 beriberi 9.6
698 polyneuropathy 9.6
699 squamous cell papilloma 9.6
700 amenorrhea 9.6
701 interstitial cystitis 9.6
702 small intestine lymphoma 9.6
703 alcoholic liver cirrhosis 9.6
704 chronic purulent otitis media 9.6
705 sclerosing cholangitis 9.6
706 ascending cholangitis 9.6
707 estrogen excess 9.6
708 gonadal dysgenesis 9.6
709 root resorption 9.6
710 prostatitis 9.6
711 aggressive periodontitis 9.6
712 methylmalonic acidemia 9.6
713 cholera 9.6
714 urticaria 9.6
715 thrombocytopenia 9.6
716 cystitis 9.6
717 squamous cell carcinoma 9.6
718 pericarditis 9.6
719 viral hepatitis 9.6
720 bardet-biedl syndrome 9.6
721 cerebral palsy 9.6
722 encephalomalacia 9.6
723 dental caries 9.6
724 vulvovaginitis 9.6
725 iron metabolism disease 9.6
726 gangliocytoma 9.6
727 glomus tumor 9.6
728 acromegaly 9.6
729 retinal vascular disease 9.6
730 corneal dystrophy 9.6
731 adenomyoma 9.6
732 papilloma 9.6
733 cystic teratoma 9.6
734 leydig cell tumor 9.6
735 contact dermatitis 9.6
736 cockayne syndrome 9.6
737 germ cell cancer 9.6
738 sertoli-leydig cell tumor 9.6
739 cystic lymphangioma 9.6
740 interstitial lung disease 9.6
741 multiple endocrine neoplasia 9.6
742 lipid metabolism disorder 9.6
743 complex regional pain syndrome 9.6
744 embryonal rhabdomyosarcoma 9.6
745 bipolar disorder 9.6
746 fibrosarcoma 9.6
747 turner syndrome 9.6
748 ovarian gonadoblastoma 9.6
749 extramedullary plasmacytoma 9.6
750 plasmacytoma 9.6
751 vaginal discharge 9.6
752 pituitary adenoma 9.6
753 colonic pseudo-obstruction 9.6
754 ganglioneuroblastoma 9.6
755 spindle cell sarcoma 9.6
756 smooth muscle tumor 9.6
757 pustulosis of palm and sole 9.6
758 rhinitis 9.6
759 intrahepatic cholangiocarcinoma 9.6
760 poliomyelitis 9.6
761 thyroid gland disease 9.6
762 ganglioglioma 9.6
763 ovarian cyst 9.6
764 plexiform neurofibroma 9.6
765 endometrial stromal tumor 9.6
766 aortitis 9.6
767 gingival hypertrophy 9.6
768 pneumonia 9.6
769 adenosquamous breast carcinoma 9.6
770 oral submucous fibrosis 9.6
771 hemolytic anemia 9.6
772 juvenile type testicular granulosa cell tumor 9.6
773 connective tissue disease 9.6
774 overnutrition 9.6
775 spondylitis 9.6
776 juvenile rheumatoid arthritis 9.6
777 infiltrating lipoma 9.6
778 t-cell lymphoblastic leukemia/lymphoma 9.6
779 thyroiditis 9.6
780 end stage renal disease 9.6
781 hyperthyroidism 9.6
782 cataract 9.6
783 osteoarthritis 9.6
784 polycythemia 9.6
785 postgastrectomy syndrome 9.6
786 ileus 9.6
787 lung disease 9.6
788 chronic fatigue syndrome 9.6
789 seborrheic dermatitis 9.6
790 lupus erythematosus 9.6
791 neuromyelitis optica 9.6
792 psoriasis 9.6
793 dermatophytosis 9.6
794 skin melanoma 9.6
795 homocystinuria 9.6
796 episodic ataxia 9.6
797 stomatitis 9.6
798 biliary tract disease 9.6
799 refractive error 9.6
800 hemophilia 9.6
801 cantú syndrome and related disorders 9.6
802 congenital disorders of n-linked glycosylation and multiple pathway 9.6
803 efemp2-related cutis laxa 9.6
804 heritable thoracic aortic disease 9.6
805 isolated methylmalonic acidemia 9.6
806 med12-related disorders 9.6
807 ppp2r5d-related neurodevelopmental disorder 9.6
808 candida glabrata 9.6
809 cavernous lymphangioma 9.6
810 congenital femoral deficiency 9.6
811 encephalocele 9.6
812 exfoliative dermatitis 9.6
813 extracranial arteriovenous malformation 9.6
814 fibro-adipose vascular anomaly 9.6
815 germ cells tumors 9.6
816 leukemia, t-cell, chronic 9.6
817 leukoplakia 9.6
818 lymphangiomatosis 9.6
819 lymphosarcoma 9.6
820 oral cancer 9.6
821 ring chromosome 4 9.6
822 sacrococcygeal teratoma 9.6
823 trichothiodystrophy 9.6
824 windblown hand 9.6
825 19p13.13 deletion syndrome 9.6
826 central precocious puberty 9.6
827 color vision deficiency 9.6
828 autonomic dysfunction 9.6
829 brain injury 9.6
830 hypertonia 9.6
831 spasticity 9.6
832 traumatic brain injury 9.6
833 tremor 9.6
834 progeroid syndrome 9.6
835 segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome 9.6
836 rapidly involuting congenital hemangioma 9.6
837 hemimelia 9.6
838 uniparental disomy of chromosome 7 9.6
839 isolated megalencephaly 9.6
840 zimmermann-laband syndrome 9.6
841 rare lymphatic malformation 9.6
842 adenosarcoma of the cervix uteri 9.6
843 pouchitis 9.6
844 semilobar holoprosencephaly 9.6
845 inverse klippel-trenaunay syndrome 9.6
846 ring chromosome 9.6
847 congenital pseudoarthrosis of the tibia 9.6
848 familial intrahepatic cholestasis 9.6
849 growing teratoma syndrome 9.6
850 ovarian fibroma 9.6
851 refractory celiac disease 9.6
852 avascular necrosis 9.6
853 intestinal polyposis syndrome 9.6
854 thyroid carcinoma 9.6

Graphical network of the top 20 diseases related to Overgrowth Syndrome:



Diseases related to Overgrowth Syndrome

Symptoms & Phenotypes for Overgrowth Syndrome

MGI Mouse Phenotypes related to Overgrowth Syndrome:

45 (showing 8, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 APC2 CHD8 DIS3L2 DNMT3A EML1 IGF2
2 growth/size/body region MP:0005378 10.13 APC2 CHD8 DIS3L2 DNMT3A EML1 GPC3
3 craniofacial MP:0005382 10.01 EML1 GPC3 IGF2 NFIX NPPC NPR2
4 embryo MP:0005380 9.97 CHD8 DNMT3A GPC3 IGF2 NSD1 PDGFRB
5 mortality/aging MP:0010768 9.93 CHD8 DIS3L2 DNMT3A GPC3 IGF2 NFIX
6 limbs/digits/tail MP:0005371 9.73 GPC3 IGF2 NPPC NPR2 PDGFRB SETD2
7 nervous system MP:0003631 9.73 APC2 CHD8 DNMT3A EML1 IGF2 KCNK4
8 skeleton MP:0005390 9.36 DIS3L2 DNMT3A EML1 GPC3 IGF2 NFIX

Drugs & Therapeutics for Overgrowth Syndrome

Drugs for Overgrowth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 319, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Lubiprostone Approved, Investigational Phase 4 136790-76-6 656719
3
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
4
Lactulose Approved Phase 4 4618-18-2 11333
5
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
6
Olodaterol Approved Phase 4 868049-49-4
7
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
8 Fluoroquinolones Phase 4
9 Clindamycin phosphate Phase 4
10 Clindamycin palmitate Phase 4
11 Cola Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Cholinergic Agents Phase 4
14 Neurotransmitter Agents Phase 4
15 Bromides Phase 4
16 Amoxicillin-Potassium Clavulanate Combination Phase 4
17 beta-Lactamase Inhibitors Phase 4
18 Anti-Inflammatory Agents Phase 4
19 Cathartics Phase 4
20 Laxatives Phase 4
21 Polyethylene glycol 3350 Phase 4
22 Respiratory System Agents Phase 4
23 Parasympatholytics Phase 4
24 Anti-Allergic Agents Phase 4
25 Anti-Asthmatic Agents Phase 4
26 Bronchodilator Agents Phase 4
27 Tiotropium Bromide Phase 4 136310-93-5
28 Cholinergic Antagonists Phase 4
29
Propranolol Approved, Investigational Phase 3 525-66-6 4946
30
Sodium citrate Approved, Investigational Phase 3 68-04-2
31
Phenytoin Approved, Vet_approved Phase 3 57-41-0 1775
32
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
33
Norfloxacin Approved Phase 3 70458-96-7 4539
34
Tobramycin Approved, Investigational Phase 3 32986-56-4 36294 5496
35
Lactitol Approved, Investigational Phase 3 585-88-6, 585-86-4 493591
36
Stavudine Approved, Investigational Phase 3 3056-17-5 18283
37
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
38
Fosamprenavir Approved Phase 3 226700-79-4 131536
39
Glycerol Approved, Investigational Phase 3 56-81-5 753
40
Ceftriaxone Approved Phase 3 73384-59-5 5361919 5479530
41
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
42
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
43
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
44
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
45
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
46
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
47
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
48 Adrenergic beta-Antagonists Phase 3
49 Antihypertensive Agents Phase 3
50 Adrenergic Antagonists Phase 3
51 Adrenergic Agents Phase 3
52 Anti-Arrhythmia Agents Phase 3
53 Vasodilator Agents Phase 3
54 Citrate Phase 3
55 Hematinics Phase 3
56 Albumin-Bound Paclitaxel Phase 3
57 Contraceptive Agents Phase 2, Phase 3
58 Nonoxynol Phase 2, Phase 3
59 Spermatocidal Agents Phase 2, Phase 3
60 Ophthalmic Solutions Phase 3
61 Acidophilus Phase 3
62 Antiparasitic Agents Phase 3
63 Antiprotozoal Agents Phase 3
64 Tubulin Modulators Phase 3
65 Antimitotic Agents Phase 3
66
Liposomal doxorubicin Phase 3 31703
67 Cactinomycin Phase 3
68 Penicillin G Benzathine Phase 3
69 Cephalosporins Phase 3
70 Penicillin G Procaine Phase 3
71 penicillins Phase 3
72 Gentamicins Phase 3
73 Pharmaceutical Solutions Phase 2, Phase 3
74
Povidone-iodine Approved Phase 2 25655-41-8
75
Povidone Approved Phase 2 9003-39-8
76
Benzoyl peroxide Approved Phase 2 94-36-0 7187
77
Wormwood Approved, Experimental Phase 1, Phase 2
78
Milk thistle Approved, Experimental, Investigational Phase 1, Phase 2 65666-07-1
79
Clove Approved Phase 1, Phase 2 84961-50-2
80 Artichoke Approved Phase 1, Phase 2
81
Turmeric Approved, Experimental, Investigational Phase 1, Phase 2
82
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
83
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
84
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
85
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
86
Azithromycin Approved Phase 2 83905-01-5 447043 55185
87
lanreotide Approved Phase 2 108736-35-2
88
Gemcitabine Approved Phase 2 95058-81-4 60750
89
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
90
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
91
Rilonacept Approved, Investigational Phase 1, Phase 2 501081-76-1 104924
92
Ustekinumab Approved, Investigational Phase 1, Phase 2 815610-63-0
93
Trametinib Approved Phase 2 871700-17-3 11707110
94
Taurine Approved, Nutraceutical Phase 1, Phase 2 107-35-7 1123
95
Methionine Approved, Nutraceutical Phase 1, Phase 2 63-68-3 6137
96
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
97
Betaine Approved, Nutraceutical Phase 1, Phase 2 107-43-7 247
98 Cyclosporins Phase 2
99 Olive Phase 1, Phase 2
100 Alpha-lipoic Acid Phase 1, Phase 2
101 Detox adjuvant Phase 1, Phase 2
102 Thioctic Acid Phase 1, Phase 2
103 Sweet Wormwood Phase 1, Phase 2
104 Turmeric extract Phase 1, Phase 2
105 Mugwort Phase 1, Phase 2
106 Grapefruit Seed Extract Phase 1, Phase 2
107 abobotulinumtoxinA Phase 2
108 Botulinum Toxins Phase 2
109 Botulinum Toxins, Type A Phase 2
110 Calcineurin Inhibitors Phase 2
111 Anti-Bacterial Agents Phase 2
112 Antibiotics, Antitubercular Phase 2
113 Anti-Infective Agents Phase 2
114 Antifungal Agents Phase 2
115 Antiviral Agents Phase 2
116 Angiopeptin Phase 2
117 Estrogens Phase 2
118 Antimetabolites Phase 2
119 Ulipristal acetate Phase 2 126784-99-4
120 Dermatologic Agents Phase 1, Phase 2
121 Interleukin-12 Phase 1, Phase 2
122 Cholinesterase Inhibitors Phase 1, Phase 2
123 Pyridostigmine Bromide Phase 1, Phase 2 101-26-8
124 Protein Kinase Inhibitors Phase 2
125 Antirheumatic Agents Phase 1, Phase 2