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MCID: OVR063
MIFTS: 53

Overnutrition

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Overnutrition

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MalaCards integrated aliases for Overnutrition:

Name: Overnutrition 12 44 15 73

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:654
MeSH 44 D044343
SNOMED-CT 68 302872003
UMLS 73 C1257763
Sources

Summaries for Overnutrition

About this section
MalaCards based summary : Overnutrition is related to gestational diabetes and liver disease. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Zinc and Exenatide have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and brain, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : 76 Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

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Related Diseases for Overnutrition

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Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 gestational diabetes 31.4 ADIPOQ INS LEP RETN
2 liver disease 30.9 ADIPOQ INS LEP TNF
3 glucose intolerance 30.8 ADIPOQ GHRL INS LEP LEPR RETN
4 fatty liver disease 30.2 ADIPOQ IL6 INS LEP LEPR PPARG
5 diabetes mellitus, noninsulin-dependent 29.9 ADIPOQ CRP GHRL IL6 INS LEP
6 acquired generalized lipodystrophy 11.2 ADIPOQ LEP RETN
7 endocrine pancreas disease 11.2 ADIPOQ INS LEP
8 abdominal obesity-metabolic syndrome quantitative trait locus 2 11.2 CRP INS LEP
9 idiopathic recurrent pericarditis 11.2 ADIPOQ LEP RETN
10 malignant otitis externa 11.2 CRP INS
11 familial partial lipodystrophy 11.1 INS LEP PPARG
12 idiopathic edema 11.1 ADIPOQ INS PPARG
13 nontuberculous mycobacterial lung disease 11.1 ADIPOQ LEP TNF
14 coronary artery aneurysm 11.1 ADIPOQ LEP RETN
15 acute insulin response 11.1 CRP INS UCP1
16 abdominal obesity-metabolic syndrome 1 11.1 ADIPOQ INS LEP PPARG
17 acanthosis nigricans 11.1 ADIPOQ INS LEP PPARG
18 achromatopsia 3 11.1 AGRP MC4R TRPV1
19 scorpion envenomation 11.1 IL6 TNF
20 hyperglycemia 11.0 ADIPOQ INS LEP PPARG
21 inherited metabolic disorder 11.0 ADIPOQ CRP INS LEP
22 nonalcoholic steatohepatitis 11.0 ADIPOQ INS LEP TNF
23 nutritional deficiency disease 11.0 CRP GHRL LEP
24 severe pre-eclampsia 11.0 ADIPOQ LEP LEPR
25 cold agglutinin disease 11.0 CRP IL6
26 burning mouth syndrome 11.0 IL6 TNF TRPV1
27 anca-associated vasculitis 11.0 GHRL IL6 TNF
28 protein-energy malnutrition 11.0 IL6 LEP TNF
29 sleep disorder 11.0 CRP IL6 LEP
30 rosacea 11.0 IL6 TNF TRPV1
31 pulpitis 11.0 IL6 TNF TRPV1
32 lacrimal apparatus disease 11.0 IL6 TNF TRPV1
33 uremia 11.0 CRP INS LEP RETN
34 obesity-hypoventilation syndrome 11.0 ADIPOQ IL6 LEP RETN
35 intermittent explosive disorder 11.0 CRP IL6 NPY
36 bladder disease 11.0 CRP IL6 TRPV1
37 central nervous system vasculitis 11.0 CRP IL6 TNF
38 louse-borne relapsing fever 11.0 CRP IL6 TNF
39 coronary heart disease 1 11.0 ADIPOQ CRP INS RETN
40 bulimia nervosa 11.0 GHRL LEP NPY
41 extrinsic cardiomyopathy 11.0 IL6 TNF TNNI3K
42 systolic heart failure 11.0 CRP IL6 TNF
43 adult-onset still's disease 11.0 CRP IL6 TNF
44 perinatal necrotizing enterocolitis 11.0 CRP IL6 TNF
45 infective endocarditis 10.9 CRP IL6 TNF
46 hemorrhagic fever with renal syndrome 10.9 CRP IL6 TNF
47 lymph node disease 10.9 CRP IL6 TNF
48 exanthem 10.9 CRP IL6 TNF
49 female reproductive system disease 10.9 IL6 INS TNF TRPV1
50 uterine anomalies 10.9 CRP IL6 TNF

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to Overnutrition
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Symptoms & Phenotypes for Overnutrition

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MGI Mouse Phenotypes related to Overnutrition:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.51 AGRP GHRL IL6 CRAT CRP ADIPOQ
2 adipose tissue MP:0005375 10.49 IL6 ADIPOQ FTO AGRP GHRL LEPR
3 behavior/neurological MP:0005386 10.42 GHRL AGRP IL6 ADIPOQ FTO LEPR
4 growth/size/body region MP:0005378 10.4 AGRP CRAT IL6 ADIPOQ FTO LEPR
5 cardiovascular system MP:0005385 10.38 CRAT IL6 CRP ADIPOQ LEPR LEP
6 cellular MP:0005384 10.34 CRAT ADIPOQ INS IL6 LEP LEPR
7 immune system MP:0005387 10.31 CRP ADIPOQ FTO INS LEPR IL6
8 liver/biliary system MP:0005370 10.3 AGRP IL6 ADIPOQ FTO LEPR LEP
9 endocrine/exocrine gland MP:0005379 10.19 GHRL ADIPOQ FTO INS IL6 LEP
10 integument MP:0010771 10.18 ADIPOQ FTO INS LEPR IL6 LEP
11 digestive/alimentary MP:0005381 10.15 GHRL INS IL6 LEP NPY LEPR
12 nervous system MP:0003631 10.11 AGRP FGF1 INS IL6 LEP MC4R
13 muscle MP:0005369 10.09 CRAT ADIPOQ INS IL6 LEP LEPR
14 neoplasm MP:0002006 10.01 ADIPOQ LEPR IL6 LEP PPARG MC4R
15 normal MP:0002873 9.91 GHRL AGRP FGF1 INS MC4R NPY
16 no phenotypic analysis MP:0003012 9.87 AGRP INS PPARG MC4R LEPR TNF
17 renal/urinary system MP:0005367 9.81 ADIPOQ FTO INS LEPR IL6 LEP
18 respiratory system MP:0005388 9.5 ADIPOQ IL6 LEP MC4R LEPR TNF
19 skeleton MP:0005390 9.36 ADIPOQ FTO INS LEPR IL6 LEP
Sources

Drugs & Therapeutics for Overnutrition

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Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 595)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 7440-66-6 23994
2
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 141758-74-9 15991534
3
Orlistat Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 96829-58-2 3034010
4
Menthol Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 2216-51-5 16666
5
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
6
Methylene blue Approved, Investigational Phase 4,Phase 1,Phase 2 61-73-4
7
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
8
Glycerol Approved, Investigational Phase 4,Not Applicable 56-81-5 753
9
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 11953898 44475014
10
Clozapine Approved Phase 4 5786-21-0 2818
11
Aspirin Approved, Vet_approved Phase 4,Early Phase 1 50-78-2 2244
12
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
13
Rocuronium Approved Phase 4,Phase 2,Not Applicable 119302-91-9, 143558-00-3 441290
14
Midazolam Approved, Illicit Phase 4,Phase 1,Not Applicable 59467-70-8 4192
15
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
16
Acetaminophen Approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
17
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
18
Saxagliptin Approved Phase 4 361442-04-8 11243969
19 Nadroparin Approved, Investigational Phase 4 9041-08-1
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
21
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
22
Irbesartan Approved, Investigational Phase 4,Not Applicable 138402-11-6 3749
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 437-38-7 3345
24
Angiotensin II Approved, Investigational Phase 4,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
25
Dalteparin Approved Phase 4,Phase 1 9005-49-6
26
Enoxaparin Approved Phase 4,Phase 1,Phase 2 9005-49-6 772
27
Spironolactone Approved Phase 4,Not Applicable 1952-01-7, 52-01-7 5833
28
Sulfamethoxazole Approved Phase 4 723-46-6 5329
29
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 111025-46-8 4829
30
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
31
Infliximab Approved Phase 4 170277-31-3
32
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
33
Ursodeoxycholic acid Approved, Investigational Phase 4,Not Applicable 128-13-2 31401
34
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
35
Ethambutol Approved Phase 4 74-55-5 3279 14052
36
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 73590-58-6 4594
37
Topiramate Approved Phase 4,Phase 3,Phase 2,Not Applicable 97240-79-4 5284627
38
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2 58-93-5 3639
39
Cefazolin Approved Phase 4,Not Applicable 25953-19-9 656510 33255
40
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
41
Galantamine Approved Phase 4 357-70-0 9651
42
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
43
Phentermine Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 122-09-8 4771
44
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
45
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
46
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
47
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
48
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 9552079 2713
49
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 83150-76-9 383414 6400441
50
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 5949-44-0

Interventional clinical trials:

(show top 50) (show all 2256)
# Name Status NCT ID Phase Drugs
1 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
2 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
3 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
4 The Therapeutic Effect of Catgut Embedding in Obesity Unknown status NCT02276235 Phase 4
5 Prevention and Control of Obesity in Primary School Children in Tehran Unknown status NCT02082080 Phase 4
6 Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity Unknown status NCT01970202 Phase 4 40mg Enoxaparin;60mg Enoxaparin
7 Pharmacokinetics of Dexmedetomidine in Morbid Obesity Unknown status NCT01864187 Phase 4 Dexmedetomidine
8 Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population. Unknown status NCT01700738 Phase 4
9 Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity Unknown status NCT01550601 Phase 4
10 The Effect of Vitamin A Supplementation on Cytokine Profile in Obesity Unknown status NCT01405352 Phase 4
11 Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function Unknown status NCT02206256 Phase 4 Omega-3 fatty acid capsules
12 Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions Unknown status NCT02118844 Phase 4 rocuronium
13 VAS Correlation With BMI Unknown status NCT02017314 Phase 4 Morphine
14 Pharmacokinetics of Acetaminophen in Morbidly Obese Patients Unknown status NCT01764555 Phase 4 acetaminophen 2 g
15 Banded Versus Conventional Laparoscopic Roux-en-Y (GABY) Unknown status NCT01015469 Phase 4
16 Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy Unknown status NCT00667706 Phase 4
17 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
18 The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine Unknown status NCT01654640 Phase 4 Metformin;Placebo (for metformin)
19 Vitamin Deficiencies and Suppletion in Morbid Obesity Unknown status NCT02270749 Phase 4 Hydroxocobalamin;FitForMe vitamin B12
20 Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity Unknown status NCT00288873 Phase 4 Ergocalciferol;Cholecalciferol
21 Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity Unknown status NCT00134303 Phase 4 Metformin
22 The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension Unknown status NCT01360710 Phase 4 Moxonidine;Irbesartan
23 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
24 Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients Unknown status NCT00871845 Phase 4 Orlistat
25 Prophylaxis of Venous Thromboembolism After Bariatric Surgery Unknown status NCT02295150 Phase 4 Nadroparin
26 CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug Unknown status NCT01519726 Phase 4 Midazolam
27 Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers Completed NCT01090141 Phase 4 Micafungin;Micafungin
28 Bread in Overweight/Obesity Treatment Completed NCT01223989 Phase 4
29 BIFI-OBESE: Clinical Trial in Paediatric Obesity Completed NCT03261466 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
30 A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents Completed NCT02714062 Phase 4 Placebo;VI-0521 Mid Dose;VI-0521 Top Dose
31 Use of Metformin in Treatment of Childhood Obesity Completed NCT02274948 Phase 4 Metformin;Placebo
32 Auricular Acupuncture in the Treatment of Obesity Completed NCT02269371 Phase 4
33 GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men Completed NCT02170324 Phase 4 Exenatide;Placebo
34 Increased Cefazolin During Cesarean Delivery in Obese Population Completed NCT02049944 Phase 4 Cefazolin
35 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
36 Enoxaparin Dosing in Obesity Completed NCT01798550 Phase 4 Enoxaparin
37 Evaluation of a Commercial Gaming Impact in a Childhood Obesity Intervention Completed NCT01757925 Phase 4
38 Clinical Trial Between Laparoscopic Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty for Morbid Obesity Completed NCT01639677 Phase 4
39 Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations Completed NCT01307930 Phase 4 Anidulafungin
40 A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women Completed NCT01206413 Phase 4
41 Effect of Weight and/or Obesity on Caspofungin Drug Concentrations Completed NCT01062165 Phase 4 Caspofungin
42 Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs) Completed NCT00694811 Phase 4
43 Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band Completed NCT00543140 Phase 4
44 A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients Completed NCT00171613 Phase 4 Octreotide
45 Pediatric Hypothalamic Obesity Completed NCT00076362 Phase 4 Sandostatin LAR
46 Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia Completed NCT03358524 Phase 4 Vitamin E 400 UNT;Placebo oral capsule
47 Micafungin Pharmacokinetics in Obese Patients Completed NCT03102658 Phase 4 Micafungin
48 Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery Completed NCT02778958 Phase 4 paracetamol;ibuprofen
49 Surgical Conditions During Laparoscopic Bariatric Surgery Completed NCT02703909 Phase 4 Rocuronium
50 Preoperative Condition in Giant Obese Patients Completed NCT02616003 Phase 4 Liraglutide

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

Sources

Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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MalaCards organs/tissues related to Overnutrition:

41
Liver, Heart, Brain, Bone, Testes, Endothelial, Kidney
Sources

Publications for Overnutrition

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Articles related to Overnutrition:

(show top 50) (show all 226)
# Title Authors Year
1
Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats. ( 29777232 )
2018
2
Fetal Overnutrition and Adolescent Hepatic Fat Fraction: the Exploring Perinatal Outcomes in Children Study. ( 29046229 )
2018
3
Sociodemographic and geographical inequalities in under- and overnutrition among children and mothers in Bangladesh: a spatial modelling approach to a nationally representative survey. ( 29717690 )
2018
4
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice. ( 29390923 )
2018
5
Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. ( 29956204 )
2018
6
Prevalence and sociodemographic determinants of adult obesity: a large representative household survey in a resource-constrained African setting with double burden of undernutrition and overnutrition. ( 29599385 )
2018
7
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or I^ Cell Metabolism in the Absence of Overnutrition. ( 29972782 )
2018
8
The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent. ( 29077836 )
2018
9
Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance. ( 29812971 )
2018
10
Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin. ( 29632515 )
2018
11
Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone I^-Subunit in Peripubertal Male Rats. ( 29706935 )
2018
12
Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters. ( 28527530 )
2017
13
Placental Lipid and Fatty Acid Transfer in Maternal Overnutrition. ( 28301855 )
2017
14
Exacerbation of liver steatosis following exposure to famine and overnutrition. ( 28499082 )
2017
15
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. ( 28677122 )
2017
16
Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. ( 28081146 )
2017
17
Fetal overnutrition and offspring insulin resistance and I^-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study. ( 28636758 )
2017
18
Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. ( 28940822 )
2017
19
Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition. ( 28794439 )
2017
20
Effects of early overnutrition on the renal response to Ang II and expression of RAAS components in rat renal tissue. ( 28958692 )
2017
21
Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. ( 28594364 )
2017
22
An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. ( 28697444 )
2017
23
Postnatal overnutrition affects metabolic and vascular function reflected by physiological and histological changes in the aorta of adult Wistar rats. ( 29115861 )
2017
24
Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. ( 28759122 )
2017
25
Preparing for the first breath: in the developing lung, maternal overnutrition takes center stage. ( 28925540 )
2017
26
Overnutrition, ectopic lipid and the metabolic syndrome. ( 27194746 )
2016
27
Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats. ( 27469432 )
2016
28
Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. ( 26608021 )
2016
29
Food Insecurity Is Associated with Undernutrition but Not Overnutrition in Ecuadorian Women from Low-Income Urban Neighborhoods. ( 27110253 )
2016
30
Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. ( 27195103 )
2016
31
Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. ( 27701408 )
2016
32
From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century. ( 27544200 )
2016
33
FGF1 Mediates Overnutrition-Induced Compensatory I^-Cell Differentiation. ( 26420862 )
2015
34
Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. ( 26203167 )
2015
35
Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats. ( 26407845 )
2015
36
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. ( 25685686 )
2015
37
IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-I^ coactivator-1I+ in rats. ( 25675425 )
2015
38
Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. ( 25504042 )
2015
39
Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol. ( 26497334 )
2015
40
The Double Burden of Undernutrition and Overnutrition in Developing Countries: an Update. ( 26627492 )
2015
41
Long-term effect of early postnatal overnutrition on insulin resistance and serum fatty acid profiles in male rats. ( 26302954 )
2015
42
Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. ( 25835281 )
2015
43
The changing context of overnutrition and undernutrition in Pakistan. ( 25794668 )
2015
44
Impact of maternal overnutrition on the periconceptional period. ( 25733194 )
2015
45
Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. ( 26690419 )
2015
46
Association of Vitamin A Status with Overnutrition in Children and Adolescents. ( 26690192 )
2015
47
The double burden of under- and overnutrition and nutrient adequacy among Chinese preschool and school-aged children in 2009-2011. ( 26130296 )
2015
48
Overnutrition induces I^-cell differentiation through prolonged activation of I^-cells in zebrafish larvae. ( 24473439 )
2014
49
Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life. ( 25082159 )
2014
50
Overnutrition, mTOR signaling, and cardiovascular diseases. ( 25253086 )
2014
Sources

Variations for Overnutrition

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Expression for Overnutrition

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Search GEO for disease gene expression data for Overnutrition.
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Pathways for Overnutrition

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Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 66
Show member pathways
 13.47 ADIPOQ IL6 INS LEP LEPR PPARG
2
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.72 ADIPOQ IL6 INS LEP RETN SOCS3
3
Regulation of IFNA signaling 66
Show member pathways
 12.53 IL6 LEP LEPR SOCS3 TNF
4
Glucose / Energy Metabolism 4
12.44 ADIPOQ FTO INS PPARG UCP1
5
Prolactin Signaling Pathway 1 37
Show member pathways
 12.37 INS LEP LEPR SOCS3
6
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.31 ADIPOQ INS LEP LEPR PPARG
7
Folate Metabolism 1
Show member pathways
 12.23 CRP IL6 INS TNF
9
Insulin resistance 37
Show member pathways
 11.85 IL6 INS SOCS3 TNF
10
Type II diabetes mellitus 37 1
Show member pathways
 11.74 ADIPOQ INS SOCS3 TNF
11
IL6-mediated signaling events 1
Show member pathways
 11.72 CRP IL6 SOCS3
12
PPAR signaling pathway 37
11.64 ADIPOQ PPARG UCP1
13
Lung fibrosis 1
11.56 FGF1 IL6 TNF
14
ATF-2 transcription factor network 1
11.49 IL6 INS SOCS3
15
Differentiation Pathway 1
11.42 FGF1 IL6 INS
16
Adipogenesis 1
11.4 ADIPOQ IL6 INS LEP PPARG RETN
17
Signaling events mediated by PTP1B 1
11.37 INS LEP LEPR SOCS3
18
Adipocytokine signaling pathway 37
11.34 ADIPOQ AGRP LEP LEPR NPY SOCS3
19
IL-10 Pathway 64
11.24 IL6 SOCS3 TNF
20
Differentiation of white and brown adipocyte 1
11.05 ADIPOQ LEP PPARG
21
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 11.03 CRP LEP LEPR SOCS3
22
Transcription factor regulation in adipogenesis 1
10.9 ADIPOQ IL6 LEP PPARG TNF
23
Overview of nanoparticle effects 1
10.89 CRP IL6 TNF
24
FTO Obesity Variant Mechanism 1
10.49 FTO UCP1
Sources

GO Terms for Overnutrition

About this section

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ADIPOQ AGRP CRP FGF1 GHRL IL6
2 extracellular space GO:0005615 9.36 ADIPOQ AGRP CRP FGF1 GHRL IL6

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.91 FGF1 INS LEP TNF
2 activation of MAPK activity GO:0000187 9.86 FGF1 GHRL INS TNF
3 circadian rhythm GO:0007623 9.85 ADIPOQ AGRP LEP
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ADIPOQ IL6 INS
5 negative regulation of inflammatory response GO:0050728 9.85 ADIPOQ GHRL PPARG SOCS3
6 response to nutrient GO:0007584 9.84 ADIPOQ LEP PPARG
7 regulation of blood pressure GO:0008217 9.83 LEP NPY PPARG
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 IL6 LEP SOCS3
9 response to glucocorticoid GO:0051384 9.82 ADIPOQ IL6 TNF
10 regulation of protein phosphorylation GO:0001932 9.8 LEP SOCS3 TNF
11 glucose homeostasis GO:0042593 9.8 ADIPOQ INS LEP LEPR PPARG
12 negative regulation of fat cell differentiation GO:0045599 9.78 ADIPOQ IL6 TNF
13 feeding behavior GO:0007631 9.77 AGRP MC4R NPY
14 hormone-mediated signaling pathway GO:0009755 9.77 AGRP GHRL PPARG
15 response to insulin GO:0032868 9.77 AGRP INS LEP MC4R RETN
16 acute-phase response GO:0006953 9.74 CRP IL6 INS
17 glucose metabolic process GO:0006006 9.72 ADIPOQ GHRL INS LEP TNF
18 energy reserve metabolic process GO:0006112 9.7 LEP LEPR MC4R
19 central nervous system neuron development GO:0021954 9.69 LEP NPY
20 negative regulation of gluconeogenesis GO:0045721 9.69 ADIPOQ INS LEPR
21 interleukin-6-mediated signaling pathway GO:0070102 9.68 IL6 SOCS3
22 fatty acid oxidation GO:0019395 9.68 ADIPOQ PPARG
23 negative regulation of collagen biosynthetic process GO:0032966 9.68 IL6 PPARG
24 negative regulation of glucose import GO:0046325 9.67 LEP TNF
25 sexual reproduction GO:0019953 9.67 LEP LEPR
26 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ADIPOQ CRP PPARG
27 negative regulation of blood vessel diameter GO:0097756 9.66 CRP INS
28 leptin-mediated signaling pathway GO:0033210 9.65 LEP LEPR
29 regulation of feeding behavior GO:0060259 9.65 AGRP LEPR MC4R
30 response to nutrient levels GO:0031667 9.65 ADIPOQ GHRL INS LEP UCP1
31 regulation of bone remodeling GO:0046850 9.64 LEP LEPR
32 positive regulation of feeding behavior GO:2000253 9.63 AGRP GHRL
33 negative regulation of acute inflammatory response GO:0002674 9.63 INS PPARG
34 diet induced thermogenesis GO:0002024 9.63 MC4R TRPV1 UCP1
35 regulation of brown fat cell differentiation GO:0090335 9.62 FTO LEP
36 negative regulation of feeding behavior GO:2000252 9.61 INS MC4R RETN
37 positive regulation of appetite GO:0032100 9.58 GHRL NPY
38 regulation of metabolic process GO:0019222 9.58 LEP MC4R
39 bone growth GO:0098868 9.54 LEP LEPR
40 adult feeding behavior GO:0008343 9.46 AGRP GHRL LEP NPY
41 regulation of signaling receptor activity GO:0010469 9.32 ADIPOQ AGRP FGF1 GHRL IL6 INS
42 negative regulation of lipid storage GO:0010888 9.26 CRP IL6 LEP TNF

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 ADIPOQ AGRP CRAT LEP NPY
2 identical protein binding GO:0042802 9.5 ADIPOQ CRP INS LEPR PPARG TNF
3 hormone activity GO:0005179 9.1 ADIPOQ GHRL INS LEP NPY RETN
Sources

Sources for Overnutrition

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51