MCID: OVR063
MIFTS: 42

Overnutrition

Categories: Metabolic diseases

Aliases & Classifications for Overnutrition

MalaCards integrated aliases for Overnutrition:

Name: Overnutrition 12 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:654
MeSH 44 D044343
SNOMED-CT 67 302872003
UMLS 70 C1257763

Summaries for Overnutrition

Disease Ontology : 12 A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content.

MalaCards based summary : Overnutrition is related to nutritional deficiency disease and body mass index quantitative trait locus 11. An important gene associated with Overnutrition is INS (Insulin), and among its related pathways/superpathways are AMP-activated Protein Kinase (AMPK) Signaling and Circadian rythm related genes. The drugs Histamine and Betahistine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and skeletal muscle.

Wikipedia : 73 Overnutrition (also known as hyperalimentation) is a form of malnutrition in which the intake of... more...

Related Diseases for Overnutrition

Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 nutritional deficiency disease 32.3 SERPINA3 LEP H2AC18 CCR6 ADIPOQ
2 body mass index quantitative trait locus 11 32.3 SOCS3 SERPINA3 PPARG MIR29A MIR21 MIR199A1
3 fatty liver disease 31.4 PPARG MIR122 LEP INS ADIPOQ
4 non-alcoholic fatty liver disease 31.4 SOCS3 PPARG MIR21 MIR199A1 MIR155 MIR126
5 hyperinsulinism 31.3 PPARG LEP INS ADIPOQ
6 glucose intolerance 31.3 PPARG LEP INS ADIPOQ
7 hyperglycemia 31.2 PPARG LEP INS ADIPOQ
8 non-alcoholic steatohepatitis 31.1 PPARG MIR21 MIR122 INS ADIPOQ
9 lipid metabolism disorder 31.1 PPARG MIR126 MIR122 LEP INS ADIPOQ
10 gestational diabetes 31.1 PPARG LEP INS ADIPOQ
11 liver disease 31.0 SERPINA3 MIR122 LEP INS ADIPOQ
12 atherosclerosis susceptibility 30.9 PPARG LEP INS ADIPOQ
13 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 30.7 PPARG LEP INS ADIPOQ
14 acanthosis nigricans 30.6 PPARG LEP INS ADIPOQ
15 kidney cancer 30.6 MIR29A MIR21 MIR199A1 MIR126 MIR122
16 lymphoma, non-hodgkin, familial 30.6 SERPINA3 MIR21 MIR199A1 MIR155 MIR126 H2AC18
17 type 2 diabetes mellitus 30.5 SOCS3 PPARG MIR29A MIR126 MIR122 LEP
18 proteasome-associated autoinflammatory syndrome 1 30.5 PPARG INS ADIPOQ
19 hypervitaminosis a 10.9
20 hypervitaminosis d 10.9
21 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.6 PPARG LEP INS ADIPOQ
22 complete generalized lipodystrophy 10.6 PPARG LEP INS ADIPOQ
23 adult syndrome 10.6 PPARG LEP INS H2AC18 ADIPOQ
24 maturity-onset diabetes of the young, type 1 10.6 PPARG LEP INS ADIPOQ
25 skin tag 10.6 SERPINA3 LEP INS
26 eating disorder 10.6 LEP FTO AGRP ADIPOQ
27 maturity-onset diabetes of the young 10.6 PPARG LEP INS H2AC18 FTO
28 lipodystrophy, familial partial, type 2 10.6 PPARG LEP INS ADIPOQ
29 idiopathic edema 10.6 PPARG INS ADIPOQ
30 acute cystitis 10.6 SERPINA3 INS H2AC18 CCR6
31 familial partial lipodystrophy 10.6 PPARG LEP INS ADIPOQ
32 leptin deficiency or dysfunction 10.6 SOCS3 PPARG LEP INS FTO AGRP
33 retinal vascular disease 10.6 MIR21 MIR199A1 MIR126 INS H2AC18
34 autoimmune disease of gastrointestinal tract 10.6 SERPINA3 MIR199A1 INS H2AC18 CCR6
35 bacterial infectious disease 10.6 SERPINA3 MIR155 H2AC18 CCR6
36 extrinsic cardiomyopathy 10.6 SERPINA3 MIR21 MIR199A1 H2AC18 CCR6
37 gastrointestinal system benign neoplasm 10.6 SERPINA3 MIR21 MIR199A1 INS H2AC18 CCR6
38 mental depression 10.6 SERPINA3 INS H2AC18 CCR6
39 placenta disease 10.6 SERPINA3 MIR199A1 INS H2AC18 ADIPOQ
40 substance abuse 10.6 SERPINA3 MIR199A1 INS H2AC18 CCR6
41 parasitic helminthiasis infectious disease 10.6 SERPINA3 MIR21 H2AC18 CCR6
42 hair disease 10.6 SERPINA3 INS H2AC18 CCR6
43 intestinal benign neoplasm 10.6 SERPINA3 MIR21 MIR199A1 H2AC18 CCR6
44 abdominal obesity-metabolic syndrome 1 10.6 PPARG MIR122 LEP INS ADIPOQ
45 prediabetes syndrome 10.6 PPARG LEP INS ADIPOQ
46 bile duct adenocarcinoma 10.6 SERPINA3 MIR21 MIR199A1 H2AC18 CCR6
47 mature t-cell and nk-cell lymphoma 10.6 MIR199A1 MIR126 H2AC18 CCR6
48 bone remodeling disease 10.6 SERPINA3 MIR199A1 MIR122 LEP INS H2AC18
49 apnea, obstructive sleep 10.6 LEP INS ADIPOQ
50 microcystic adenoma 10.6 SERPINA3 MIR21 MIR126

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to Overnutrition

Symptoms & Phenotypes for Overnutrition

Drugs & Therapeutics for Overnutrition

Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 1 51-45-6, 75614-87-8 774
2
Betahistine Approved, Investigational Phase 1 5638-76-6 2366
3 Vasodilator Agents Phase 1
4 Neurotransmitter Agents Phase 1
5
Histamine Phosphate Phase 1 51-74-1 65513
6
Iron Approved 7439-89-6 23925 29936
7
Zinc Approved, Investigational 7440-66-6 32051
8
Ethanol Approved Early Phase 1 64-17-5 702
9 Strawberry Approved Early Phase 1
10 Coconut Approved Early Phase 1
11
Silicon Approved, Investigational Early Phase 1 7440-21-3 4082203
12
tannic acid Approved 1401-55-4
13
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
14
gastric inhibitory polypeptide Investigational 100040-31-1
15
Rosemary Experimental Early Phase 1
16 Gastrointestinal Agents
17 Hormones
18 Hormone Antagonists
19 Incretins
20 Trace Elements
21 Micronutrients
22 Omega 3 Fatty Acid
23 Vitamins
24 Soy Bean Early Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Pilot Study of the Metabolic Effects of Betahistine Hydrochloride in Overweight Women Completed NCT00459992 Phase 1 Betahistine Hydrochloride
2 Baby-STOPP: Targeted Obesity Prevention Directed to Overweight Parents With Young Children Unknown status NCT02409875
3 Association of Early Life Nutritional Related Exposures and Long-term Health and Cognitive Development Outcomes in Adolescents in Northeast, Thailand Unknown status NCT01979770
4 Energy Expenditure and Sleep in Response to Protein/Carbohydrate and Fat Ratio Unknown status NCT01551238
5 Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue Completed NCT00774488
6 Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness Completed NCT01224561
7 Attenuating the Micronutrient Malnutrition of Overnutrition (AMMO) Completed NCT02239198
8 ChildObesity180 - Social Marketing Campaign to Encourage Healthful Eating in Restaurants for Children Completed NCT03422926
9 Community Translation of a Lifestyle Intervention to Improve Health in Diabetes Completed NCT01435603
10 A Psychoeducational Intervention Model in Nutrition to Improve Nutritional Status in a Pilot Low Resource Population in the City of Saltillo, Coahuila Mexico. Completed NCT02258802
11 A Psychoeducational Intervention Model in Nutrition to Improve Nutritional Status in 15 Low Resource Populations Through a Network of Food Banks in Mexico. Completed NCT02914002
12 Healthy Babies Through Infant Centered Feeding Completed NCT01816516
13 Clinical Investigation on the Safety of Avocado Pulp Lipids Completed NCT03898505 Early Phase 1
14 A Pragmatic Family-Centered Approach to Childhood Obesity Treatment Recruiting NCT03843424
15 The Food Intake Phenotype: Assessing Eating Behavior and Food Preferences as Risk Factors for Obesity Recruiting NCT00342732
16 Korean OBEsity Surgical Treatment Study(KOBESS-II) : Protocol of a Prospective Multicenter Cohort Study on Morbid Obesity Patients Undergoing Sleeve Gastrectomy Versus Roux-en Y Gastric Bypass Recruiting NCT04554758
17 Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care Active, not recruiting NCT03003403
18 Maternal Obesity, Breast Milk Composition, and Infant Growth Active, not recruiting NCT03301753
19 Measurement of Energy Metabolism in Infants: BabyEE Pilot Suspended NCT02683473

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

Genetic Tests for Overnutrition

Anatomical Context for Overnutrition

MalaCards organs/tissues related to Overnutrition:

40
Liver, Bone, Skeletal Muscle, Skin, Thyroid, Heart, Kidney

Publications for Overnutrition

Articles related to Overnutrition:

(show top 50) (show all 1555)
# Title Authors PMID Year
1
Adipose tissue and insulin resistance in obese. 61
33561645 2021
2
Coronavirus disease 2019 pandemic and alterations of body composition. 61
33587365 2021
3
Modulation of adipocyte size and fat pad weight via resveratrol releasing scaffolds implanted into the epididymal adipose tissue. 61
32681806 2021
4
IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. 61
33571167 2021
5
Effect of maternal overnutrition on predisposition to insulin resistance in the foal: Maternal parameters and foal pancreas histoarchitecture. 61
33636430 2021
6
Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19. 61
33569904 2021
7
Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes. 61
33352310 2021
8
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition. 61
33608323 2021
9
O-1602 Promotes Hepatic Steatosis through GPR55 and PI3 Kinase/Akt/SREBP-1c Signaling in Mice. 61
33803038 2021
10
Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk. 61
33741533 2021
11
Reduced Liver Autophagy in High-Fat Diet Induced Liver Steatosis in New Zealand Obese Mice. 61
33804819 2021
12
Coconut oil supplementation during development reduces brain excitability in adult rats nourished and overnourished in lactation. 61
33720258 2021
13
The Drosophila model to interrogate triacylglycerol biology. 61
33716135 2021
14
The framing of malnutrition by parliamentarians in Uganda. 61
33709155 2021
15
Islet isograft transplantation improves insulin sensitivity in a murine model of type 2 diabetes. 61
33713015 2021
16
Comparative study on the early growth of preterm infants with the World Health Organization growth standards and the China growth charts. 61
33713385 2021
17
n-3 PUFAs protect against adiposity and fatty liver by promoting browning in postnatally overfed male rats: a role for NRG4. 61
33705952 2021
18
Brain JNK and metabolic disease. 61
33200240 2021
19
Nutrition transition and related health challenges over decades in China. 61
32620907 2021
20
Integrating nutrition into the education sector in low- and middle-income countries: A framework for a win-win collaboration. 61
33590645 2021
21
Patterns and determinants of the double burden of malnutrition at the household level in South and Southeast Asia. 61
32879448 2021
22
Diversity and dynamism of IgA-microbiota interactions. 61
33568782 2021
23
[Role of endoplasmic reticulum stress response in regulation of adipose tissue metabolism]. 61
33665666 2021
24
Global e-Learning in Early Nutrition and Lifestyle for International Healthcare Professionals: Design and Evaluation of the Early Nutrition Specialist Programme (ENS). 61
33673535 2021
25
[Clinical application of the modified pediatric nutritional risk screening tool]. 61
33627216 2021
26
An initiative to improve nutritional education among medical students. 61
33612952 2021
27
Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53. 61
33400924 2021
28
Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation. 61
32297339 2021
29
Long-Term Glucose Starvation Induces Inflammatory Responses and Phenotype Switch in Primary Cortical Rat Astrocytes. 61
33580474 2021
30
Changing trends in nutritional status of adolescent females: a cross-sectional study from urban and rural Bangladesh. 61
33597144 2021
31
Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling. 61
33672754 2021
32
The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin. 61
33551450 2021
33
Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation. 61
33411692 2021
34
Potential role of primed microglia during obesity on the mesocorticolimbic circuit in autism spectrum disorder. 61
32902852 2021
35
Breast milk apelin level increases with maternal obesity and high-fat feeding during lactation. 61
33594258 2021
36
Mechanisms Underlying the Cognitive and Behavioural Effects of Maternal Obesity. 61
33467657 2021
37
Novel approaches to sarcopenic obesity and weight management before and after kidney transplantation. 61
33186218 2021
38
Reframing the early childhood obesity prevention narrative through an equitable nurturing approach. 61
33067918 2021
39
Concurrence of stunting and overweight/obesity among children: Evidence from Ethiopia. 61
33449970 2021
40
Hypothalamic Ceramides and the Ovarian Sympathetic System: At the Crossroads of Obesity and Puberty. 61
33264644 2021
41
Understanding the Link Between Maternal Overnutrition, Cardio-Metabolic Dysfunction and Cognitive Aging. 61
33716660 2021
42
Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes. 61
33539017 2021
43
When a pandemic and an epidemic collide: COVID-19, gut microbiota, and the double burden of malnutrition. 61
33504332 2021
44
Nutrition risk screening methods for adults living with severe mental illness: A scoping review. 61
33416212 2021
45
Protein-Energy Malnutrition Increases Mortality in Patients Hospitalized With Bacterial Pneumonia: A Retrospective Nationwide Database Analysis. 61
33585131 2021
46
Nutrition, Immune Function, and Infectious Disease. 61
33666926 2021
47
A hidden side of the COVID-19 pandemic in children: the double burden of undernutrition and overnutrition. 61
33482829 2021
48
Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep. 61
33160155 2021
49
The double burden of malnutrition in India: Trends and inequalities (2006-2016). 61
33630964 2021
50
Elicited soybean extract attenuates proinflammatory cytokines expression by modulating TLR3/TLR4 activation in high-fat, high-fructose diet mice. 61
33531194 2021

Variations for Overnutrition

Expression for Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for Overnutrition

GO Terms for Overnutrition

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.44 SERPINA3 MIR29A MIR21 MIR199A1 MIR155 MIR126
2 extracellular vesicle GO:1903561 9.35 MIR29A MIR21 MIR126 MIR122 MIR103A1

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 FGF1 INS MIR155 MIR21 MIR29A
2 positive regulation of cell migration GO:0030335 9.94 FGF1 INS MIR21 MIR29A
3 positive regulation of protein phosphorylation GO:0001934 9.88 ADIPOQ FGF1 LEP MIR21
4 negative regulation of cell migration GO:0030336 9.83 ADIPOQ MIR126 MIR21 MIR29A
5 positive regulation of inflammatory response GO:0050729 9.82 MIR126 MIR155 MIR21
6 circadian rhythm GO:0007623 9.81 ADIPOQ AGRP LEP
7 gene silencing by miRNA GO:0035195 9.8 MIR103A1 MIR122 MIR126 MIR155 MIR199A1 MIR21
8 response to nutrient GO:0007584 9.79 ADIPOQ LEP PPARG
9 glucose homeostasis GO:0042593 9.78 ADIPOQ INS LEP PPARG
10 cellular response to insulin stimulus GO:0032869 9.76 ADIPOQ LEP MIR103A1 PPARG
11 glucose metabolic process GO:0006006 9.75 ADIPOQ INS LEP
12 positive regulation of cytokine production GO:0001819 9.73 INS LEP MIR21
13 miRNA mediated inhibition of translation GO:0035278 9.73 MIR103A1 MIR155 MIR21 MIR29A
14 activation of protein kinase B activity GO:0032148 9.69 FGF1 INS MIR21
15 positive regulation of sprouting angiogenesis GO:1903672 9.67 FGF1 MIR126 MIR155
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 INS LEP MIR126 MIR21
17 negative regulation of glucose import GO:0046325 9.65 LEP MIR103A1
18 positive regulation of connective tissue replacement GO:1905205 9.65 MIR155 MIR199A1
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.64 ADIPOQ PPARG
20 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR155 MIR199A1
21 positive regulation of endothelial cell migration GO:0010595 9.62 FGF1 MIR199A1 MIR21 MIR29A
22 adult feeding behavior GO:0008343 9.61 AGRP LEP
23 negative regulation of cartilage development GO:0061037 9.61 LEP MIR21
24 negative regulation of acute inflammatory response GO:0002674 9.6 INS PPARG
25 negative regulation of regulatory T cell differentiation GO:0045590 9.59 MIR155 MIR21
26 positive regulation of vascular endothelial cell proliferation GO:1905564 9.58 MIR126 MIR21 MIR29A
27 positive regulation of necroptotic process GO:0060545 9.57 MIR103A1 MIR155
28 positive regulation of fatty acid metabolic process GO:0045923 9.55 ADIPOQ PPARG
29 positive regulation of angiogenesis GO:0045766 9.55 FGF1 MIR126 MIR199A1 MIR21 MIR29A
30 regulation of brown fat cell differentiation GO:0090335 9.54 FTO LEP
31 negative regulation of inflammatory response GO:0050728 9.35 ADIPOQ MIR126 MIR155 PPARG SOCS3
32 positive regulation of protein kinase B signaling GO:0051897 9.17 FGF1 INS LEP MIR126 MIR199A1 MIR21

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.26 MIR29A MIR21 MIR126 MIR103A1
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR29A MIR21 MIR199A1 MIR155 MIR126 MIR103A1

Sources for Overnutrition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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