Overnutrition disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: OVR063 MIFTS: 53	Overnutrition Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Overnutrition

MalaCards integrated aliases for Overnutrition:

Name: Overnutrition ¹² ⁴⁵ ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:654

MeSH ⁴⁵ D044343

UMLS ⁷⁴ C1257763

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Summaries for Overnutrition

Disease Ontology : ¹² A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content.

MalaCards based summary : Overnutrition is related to nutritional deficiency disease and body mass index quantitative trait locus 11. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Aspirin and Moxonidine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : ⁷⁷ Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

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Related Diseases for Overnutrition

Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)

#	Related Disease	Score	Top Affiliating Genes
1	nutritional deficiency disease	32.3	CRP GHRL IL6 LEP
2	body mass index quantitative trait locus 11	31.4	ADIPOQ AGRP CRP FTO GCG GHRL
3	gestational diabetes	30.9	ADIPOQ INS LEP RETN
4	liver disease	30.6	ADIPOQ IL6 INS LEP LEPR
5	fatty liver disease, nonalcoholic 1	30.6	ADIPOQ INS LEP RETN SREBF1
6	fatty liver disease	30.4	ADIPOQ IL6 INS LEP LEPR SREBF1
7	diabetes mellitus, noninsulin-dependent	30.3	ADIPOQ CRP GCG GHRL IL6 INS
8	glucose intolerance	30.1	ADIPOQ CRP GCG GHRL INS LEP
9	hypervitaminosis a	11.4
10	hypervitaminosis d	11.1
11	lipodystrophy, familial partial, type 1	10.5	INS LEP PPARG
12	complete generalized lipodystrophy	10.5	INS LEP PPARG
13	lipodystrophy, congenital generalized, type 1	10.5	ADIPOQ INS LEP
14	nonalcoholic steatohepatitis	10.5	ADIPOQ INS LEP
15	idiopathic recurrent pericarditis	10.5	ADIPOQ LEP RETN
16	malignant otitis externa	10.5	CRP INS
17	endocrine pancreas disease	10.5	ADIPOQ INS LEP
18	idiopathic edema	10.5	ADIPOQ INS PPARG
19	abdominal obesity-metabolic syndrome quantitative trait locus 2	10.5	INS LEP
20	familial partial lipodystrophy	10.5	INS LEP PPARG
21	type 1 diabetes mellitus 15	10.5	GCG INS
22	abdominal obesity-metabolic syndrome 1	10.5	ADIPOQ INS LEP PPARG
23	hypercholesterolemia, autosomal recessive	10.5	AGRP LEP NPY
24	coronary artery aneurysm	10.5	ADIPOQ LEP RETN
25	anovulation	10.5	CRP INS LEP
26	acanthosis nigricans	10.5	ADIPOQ INS LEP PPARG
27	cold agglutinin disease	10.5	CRP IL6
28	severe pre-eclampsia	10.5	ADIPOQ LEP LEPR
29	autoimmune myocarditis	10.5	IL6 PPARG
30	dumping syndrome	10.5	GCG INS PYY
31	obesity-hypoventilation syndrome	10.5	ADIPOQ IL6 LEP RETN
32	hyperinsulinemic hypoglycemia, familial, 7	10.5	GCG INS
33	sleep disorder	10.5	CRP IL6 INS LEP
34	postgastrectomy syndrome	10.5	INS PYY
35	nonalcoholic fatty liver disease	10.5	ADIPOQ INS LEP SREBF1
36	uremia	10.5	CRP INS LEP RETN
37	hyperthyroidism	10.5	GHRL INS LEP
38	lipid storage disease	10.4	ADIPOQ INS SREBF1
39	intermittent explosive disorder	10.4	CRP IL6 NPY
40	acute insulin response	10.4	CRP GCG INS UCP1
41	acquired generalized lipodystrophy	10.4	ADIPOQ INS LEP PPARG RETN
42	end stage renal failure	10.4	CRP IL6 LEP
43	maturity-onset diabetes of the young, type 9	10.4	GCG INS
44	cryopyrin-associated periodic syndrome	10.4	CRP IL6
45	urinary system disease	10.4	CRP IL6 INS
46	cerebrovascular disease	10.4	ADIPOQ CRP IL6 INS
47	apnea, obstructive sleep	10.4	ADIPOQ CRP IL6 INS LEP
48	hypercholesterolemia, familial	10.4	AGRP CRP INS NPY
49	hyperglycemia	10.4	ADIPOQ GCG INS LEP PPARG
50	inherited metabolic disorder	10.4	ADIPOQ CRP INS LEP SREBF1

Graphical network of the top 20 diseases related to Overnutrition:

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Symptoms & Phenotypes for Overnutrition

MGI Mouse Phenotypes related to Overnutrition:

⁴⁷ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.45	ADIPOQ AGRP CRAT CRP FGF1 FTO
2	adipose tissue	MP:0005375	10.42	ADIPOQ AGRP FTO GHRL IL6 INS
3	behavior/neurological	MP:0005386	10.35	ADIPOQ AGRP FTO GHRL IL6 INS
4	growth/size/body region	MP:0005378	10.34	ADIPOQ AGRP CRAT FTO IL6 INS
5	cardiovascular system	MP:0005385	10.22	ADIPOQ CRAT CRP IL6 INS LEP
6	liver/biliary system	MP:0005370	10.22	ADIPOQ AGRP FTO IL6 INS LEP
7	immune system	MP:0005387	10.2	ADIPOQ CRP FTO IL6 INS LEP
8	digestive/alimentary	MP:0005381	10.05	GHRL IL6 INS LEP LEPR NPY
9	integument	MP:0010771	10.03	ADIPOQ FTO IL6 INS LEP LEPR
10	nervous system	MP:0003631	10	ADIPOQ AGRP FGF1 IL6 INS LEP
11	muscle	MP:0005369	9.91	ADIPOQ CRAT IL6 INS LEP LEPR
12	normal	MP:0002873	9.85	AGRP FGF1 GHRL INS LEPR MC4R
13	neoplasm	MP:0002006	9.8	ADIPOQ IL6 LEP LEPR MC4R PPARG
14	renal/urinary system	MP:0005367	9.56	ADIPOQ FTO IL6 INS LEP LEPR
15	skeleton	MP:0005390	9.36	ADIPOQ FTO IL6 INS LEP LEPR

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Drugs & Therapeutics for Overnutrition

Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 658)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Aspirin

Approved, Vet_approved

Phase 4,Early Phase 1

50-78-2

2244

Moxonidine

Approved, Investigational

Phase 4

75438-57-2

4810

Dexmedetomidine

Approved, Vet_approved

Phase 4,Not Applicable

113775-47-6

68602 5311068

Dalteparin

Approved

Phase 4,Phase 1

9005-49-6

Enoxaparin

Approved

Phase 4,Phase 1,Phase 2

9005-49-6

772

chenodeoxycholic acid

Approved

Phase 4

474-25-9

10133

Octreotide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

83150-76-9

6400441 383414

Rocuronium

Approved

Phase 4,Phase 2,Not Applicable

119302-91-9, 143558-00-3

441290

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

94-09-7, 1994-09-7

2337

tannic acid

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

1401-55-4

Morphine

Approved, Investigational

Phase 4,Phase 2,Phase 3,Not Applicable

57-27-2

5288826

Acetaminophen

Approved

Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1

103-90-2

1983

Metformin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

657-24-9

14219 4091

Hydroxocobalamin

Approved

Phase 4,Phase 2

13422-51-0

11953898 15589840

Methylcobalamin

Approved, Experimental, Investigational

Phase 4,Phase 2

13422-55-4

Vildagliptin

Approved, Investigational

Phase 4

274901-16-5

6918537

Acarbose

Approved, Investigational

Phase 4

56180-94-0

441184

Angiotensin II

Approved, Investigational

Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable

68521-88-0, 11128-99-7, 4474-91-3

172198 65143

Irbesartan

Approved, Investigational

Phase 4,Not Applicable

138402-11-6

3749

Chlorhexidine

Approved, Vet_approved

Phase 4,Not Applicable

55-56-1

2713 9552079

Coal tar

Approved

Phase 4,Phase 1,Phase 2

8007-45-2

Saxagliptin

Approved

Phase 4

361442-04-8

11243969

Nadroparin

Approved, Investigational

Phase 4

Heparin

Approved, Investigational

Phase 4,Not Applicable

9005-49-6

772 46507594

Anastrozole

Approved, Investigational

Phase 4,Not Applicable

120511-73-1

2187

Exenatide

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

141758-74-9

15991534

Liraglutide

Approved

Phase 4,Phase 3,Phase 2,Phase 1

204656-20-2

44147092

Propofol

Approved, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

2078-54-8

4943

Orlistat

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

96829-58-2

3034010

leucovorin

Approved

Phase 4,Not Applicable

58-05-9

6006 143

Dopamine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

62-31-7, 51-61-6

681

Ethanol

Approved

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

64-17-5

702

Zinc

Approved, Investigational

Phase 4,Phase 2,Not Applicable,Early Phase 1

7440-66-6

32051

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4,Phase 3,Phase 1,Not Applicable

437-38-7

3345

Methylene blue

Approved, Investigational

Phase 4,Phase 1,Phase 2

61-73-4

Glycerol

Approved, Investigational

Phase 4,Not Applicable

56-81-5

753

Empagliflozin

Approved

Phase 4

864070-44-0

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Micafungin

Approved, Investigational

Phase 4

235114-32-6

477468 3081921

Topiramate

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

97240-79-4

5284627

Phentermine

Approved, Illicit

Phase 4,Phase 3,Phase 2,Not Applicable

122-09-8

4771

Cefazolin

Approved

Phase 4,Not Applicable,Early Phase 1

25953-19-9

656510 33255

Anidulafungin

Approved, Investigational

Phase 4

166663-25-8

166548

Caspofungin

Approved

Phase 4

179463-17-3, 162808-62-0

2826718 468682

Tocopherol

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1

1406-66-2

14986

Posaconazole

Approved, Investigational, Vet_approved

Phase 4

171228-49-2

147912

Ibuprofen

Approved

Phase 4,Not Applicable

15687-27-1

3672

Ursodeoxycholic acid

Approved, Investigational

Phase 4,Not Applicable

128-13-2

31401

Amphotericin B

Approved, Investigational

Phase 4

1397-89-3

14956 5280965

Atorvastatin

Approved

Phase 4,Phase 3

134523-00-5

60823

Interventional clinical trials:

(show top 50) (show all 2495)

#	Name	Status	NCT ID	Phase	Drugs
1	Type 2 Diabetes Mellitus and Atherosclerosis	Unknown status	NCT01250340	Phase 4	Aspirin;Placebo
2	Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity	Unknown status	NCT01180231	Phase 4	Moxonidine (Physiotens)
3	The Effect of Obesity in Dexmedetomidine Metabolic Clearance	Unknown status	NCT02557867	Phase 4	Dexmedetomidine
4	Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery	Unknown status	NCT02310178	Phase 4
5	The Therapeutic Effect of Catgut Embedding in Obesity	Unknown status	NCT02276235	Phase 4
6	Prevention and Control of Obesity in Primary School Children in Tehran	Unknown status	NCT02082080	Phase 4
7	Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity	Unknown status	NCT01970202	Phase 4	40mg Enoxaparin;60mg Enoxaparin
8	Pharmacokinetics of Dexmedetomidine in Morbid Obesity	Unknown status	NCT01864187	Phase 4	Dexmedetomidine
9	Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population.	Unknown status	NCT01700738	Phase 4
10	Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity	Unknown status	NCT01550601	Phase 4
11	The Effect of Vitamin A Supplementation on Cytokine Profile in Obesity	Unknown status	NCT01405352	Phase 4
12	Effect of Bile Acids and Bile Acid Sequstrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass	Unknown status	NCT02952963	Phase 4	Chenodeoxycholic Acid;Colesevelam
13	Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass	Unknown status	NCT02876484	Phase 4	Colesevelam;Chenodeoxycholic Acid
14	Gut Hormones as Mediators of Different Weight Loss Responses After Roux-en-Y Gastric Bypass	Unknown status	NCT02374632	Phase 4
15	Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions	Unknown status	NCT02118844	Phase 4	rocuronium
16	VAS Correlation With BMI	Unknown status	NCT02017314	Phase 4	Morphine
17	Pharmacokinetics of Acetaminophen in Morbidly Obese Patients	Unknown status	NCT01764555	Phase 4	acetaminophen 2 g
18	Banded Versus Conventional Laparoscopic Roux-en-Y (GABY)	Unknown status	NCT01015469	Phase 4
19	Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy	Unknown status	NCT00667706	Phase 4
20	Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity	Unknown status	NCT02438020	Phase 4	Metformin
21	Vitamin Deficiencies and Suppletion in Morbid Obesity	Unknown status	NCT02270749	Phase 4	Hydroxocobalamin;FitForMe vitamin B12
22	Effect of Laparoscopic Sleeve Gastrectomy in the Morbidly Obese, Kidney Transplant Candidate	Unknown status	NCT01913392	Phase 4
23	Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity	Unknown status	NCT00134303	Phase 4	Metformin
24	Effect of Acarbose and Vildagliptin on Visceral Fat Distribution in Newly Diagnosed Type 2 Diabetes Patients	Unknown status	NCT02999841	Phase 4	Acarbose;Vildagliptin
25	The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension	Unknown status	NCT01360710	Phase 4	Moxonidine;Irbesartan
26	Treatment of Periodontitis in Obese Individuals	Unknown status	NCT03103204	Phase 4
27	Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity	Unknown status	NCT01960205	Phase 4	Saxagliptin;saxagliptin;metformin
28	Prophylaxis of Venous Thromboembolism After Bariatric Surgery	Unknown status	NCT02295150	Phase 4	Nadroparin
29	Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot)	Unknown status	NCT02959853	Phase 4	Anastrazole
30	Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging	Completed	NCT02833415	Phase 4	[U-13C3] glycerol;Empagliflozin;Placebo (for Empagliflozin)
31	Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers	Completed	NCT01090141	Phase 4	Micafungin;Micafungin
32	Bread in Overweight/Obesity Treatment	Completed	NCT01223989	Phase 4
33	BIFI-OBESE: Clinical Trial in Paediatric Obesity	Completed	NCT03261466	Phase 4	Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
34	A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents	Completed	NCT02714062	Phase 4	Placebo;VI-0521 Mid Dose;VI-0521 Top Dose
35	Use of Metformin in Treatment of Childhood Obesity	Completed	NCT02274948	Phase 4	Metformin;Placebo
36	Auricular Acupuncture in the Treatment of Obesity	Completed	NCT02269371	Phase 4
37	GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men	Completed	NCT02170324	Phase 4	Exenatide;Placebo
38	Increased Cefazolin During Cesarean Delivery in Obese Population	Completed	NCT02049944	Phase 4	Cefazolin
39	A Toolbox Approach to Obesity Treatment in Primary Care	Completed	NCT01922934	Phase 4	Obesity pharmacotherapy
40	Enoxaparin Dosing in Obesity	Completed	NCT01798550	Phase 4	Enoxaparin
41	Evaluation of a Commercial Gaming Impact in a Childhood Obesity Intervention	Completed	NCT01757925	Phase 4
42	Clinical Trial Between Laparoscopic Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty for Morbid Obesity	Completed	NCT01639677	Phase 4
43	Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations	Completed	NCT01307930	Phase 4	Anidulafungin
44	A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women	Completed	NCT01206413	Phase 4
45	Effect of Weight and/or Obesity on Caspofungin Drug Concentrations	Completed	NCT01062165	Phase 4	Caspofungin
46	Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs)	Completed	NCT00694811	Phase 4
47	Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band	Completed	NCT00543140	Phase 4
48	A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients	Completed	NCT00171613	Phase 4	Octreotide
49	Pediatric Hypothalamic Obesity	Completed	NCT00076362	Phase 4	Sandostatin LAR
50	Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia	Completed	NCT03358524	Phase 4	Vitamin E 400 UNT;Placebo oral capsule

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

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Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

MalaCards organs/tissues related to Overnutrition:

⁴²

Liver, Brain, Heart, Bone, Testes, Endothelial, Breast

Sources

Publications for Overnutrition

Articles related to Overnutrition:

(show top 50) (show all 249)

#	Title	Authors	Year
1	Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice. ( 30842440 )	Glavas MM...Kieffer TJ	2019
2	Investigating Gene-Gene and Gene-Environment Interactions in the Association Between Overnutrition and Obesity-Related Phenotypes. ( 30886629 )	Tessier F...Roy-Gagnon MH	2019
3	Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats. ( 29777232 )	Gali Ramamoorthy T....White A.	2018
4	Fetal Overnutrition and Adolescent Hepatic Fat Fraction: the Exploring Perinatal Outcomes in Children Study. ( 29046229 )	Bellatorre A....Dabelea D.	2018
5	Sociodemographic and geographical inequalities in under- and overnutrition among children and mothers in Bangladesh: a spatial modelling approach to a nationally representative survey. ( 29717690 )	Mia M.N....Roy P.K.	2018
6	Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice. ( 29390923 )	Wolfrum C....Peleg-Raibstein D.	2018
7	Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. ( 29956204 )	Farrell G.C....Chitturi S.	2018
8	Prevalence and sociodemographic determinants of adult obesity: a large representative household survey in a resource-constrained African setting with double burden of undernutrition and overnutrition. ( 29599385 )	Chigbu C.O....Berger U.	2018
9	Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or I^ Cell Metabolism in the Absence of Overnutrition. ( 29972782 )	Peterson B.S....Newgard C.B.	2018
10	Metformin influences on respiratory system in obese mice induced by postnatal overnutrition. ( 28963087 )	Dias M.D....Soncini R.	2018
11	The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent. ( 29077836 )	Argente-ArizA^n P....Chowen J.A.	2018
12	Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance. ( 29812971 )	Ramon-Krauel M....Jimenez-Chillaron J.C.	2018
13	Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin. ( 29632515 )	FruhwA1rth S....Williams K.J.	2018
14	Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone I^-Subunit in Peripubertal Male Rats. ( 29706935 )	Argente-ArizA^n P....Chowen J.A.	2018
15	Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring. ( 29991958 )	Cardenas-Perez RE...Camacho A	2018
16	Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring. ( 30027100 )	Montalvo-Mart?nez L...Camacho A	2018
17	Both Maternal Low-Protein and Neonatal Overnutrition Result in Similar Changes to Glomerular Morphology and Renal Cortical Oxidative Stress Measures in Male Wistar Rats. ( 30058348 )	Pedroza A...Lagranha CJ	2018
18	The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition. ( 30135952 )	Peterson CS...Fry WM	2018
19	Reuniting overnutrition and undernutrition, macronutrients, and micronutrients. ( 30171821 )	Kim M...Roth J	2018
20	Postnatal overnutrition alters the orexigenic effects of melanin-concentrating hormone (MCH) and reduces MCHR1 hypothalamic expression on spontaneous feeding and fasting. ( 30196088 )	P?rez-Morales M...Vel?zquez-Moctezuma J	2018
21	Overnutrition: Does Complementary Feeding Play a Role? ( 30196296 )	Laving AR...Atieno DO	2018
22	Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. ( 30226474 )	Huang H...Kim YB	2018
23	UBE3A suppresses overnutrition-induced expression of the steatosis target genes of MLL4 by degrading MLL4. ( 30230575 )	Kim J...Lee JW	2018
24	Effect of maternal antioxidant supplementation and/or exercise practice during pregnancy on postnatal overnutrition induced by litter size reduction: Brain redox homeostasis at weaning. ( 30232036 )	August PM...Matt? C	2018
25	Overnutrition and Scholastic Achievement: Is There a Relationship? An 8-Year Follow-Up Study. ( 30308520 )	Flores OC...Ivanovic D	2018
26	Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition. ( 30315171 )	Sarker G...Peleg-Raibstein D	2018
27	Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations. ( 30577472 )	Sarker G...Peleg-Raibstein D	2018
28	Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters. ( 28527530 )	Pankey C.L....Ford S.P.	2017
29	Placental Lipid and Fatty Acid Transfer in Maternal Overnutrition. ( 28301855 )	Lewis R.M....Desoye G.	2017
30	Exacerbation of liver steatosis following exposure to famine and overnutrition. ( 28499082 )	Ning Z....Lu Y.	2017
31	From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. ( 28677122 )	Caputo T....Desvergne B.	2017
32	Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. ( 28081146 )	Robles M....Chavatte-Palmer P.	2017
33	Fetal overnutrition and offspring insulin resistance and I^-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study. ( 28636758 )	Sauder K.A....Dabelea D.	2017
34	Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. ( 28940822 )	Min J....Wang Y.	2017
35	Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition. ( 28794439 )	Ribeiro T.A....de Freitas Mathias P.C.	2017
36	Effects of early overnutrition on the renal response to Ang II and expression of RAAS components in rat renal tissue. ( 28958692 )	Granado M....GarcA-a-VillalA^n A.L.	2017
37	Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. ( 28594364 )	Mastorci F....Pingitore A.	2017
38	An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. ( 28697444 )	Zhao J....Zhuo Y.	2017
39	Postnatal overnutrition affects metabolic and vascular function reflected by physiological and histological changes in the aorta of adult Wistar rats. ( 29115861 )	SA!nchez-GarcA-a G....Hong E.	2017
40	Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. ( 28759122 )	Lock M.C....Morrison J.L.	2017
41	Preparing for the first breath: in the developing lung, maternal overnutrition takes center stage. ( 28925540 )	Rozance P.J....Wright C.J.	2017
42	Developmental programming of the pancreatic islet by in utero overnutrition. ( 29657386 )	Elsakr JM...Gannon M	2017
43	Overnutrition, ectopic lipid and the metabolic syndrome. ( 27194746 )	Grundy S.M.	2016
44	Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats. ( 27469432 )	Carvalho A.L....Giusti-Paiva A.	2016
45	Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. ( 26608021 )	Bernardo A.F....Garcia-Souza A.8.P.	2016
46	Food Insecurity Is Associated with Undernutrition but Not Overnutrition in Ecuadorian Women from Low-Income Urban Neighborhoods. ( 27110253 )	Weigel M.M....Cevallos W.	2016
47	Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. ( 27195103 )	Argente-ArizA^n P....Chowen J.A.	2016
48	Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. ( 27701408 )	Peleg-Raibstein D....Wolfrum C.	2016
49	From Undernutrition to Overnutrition: The Evolution of Overweight and Obesity among Young Men in Switzerland since the 19th Century. ( 27544200 )	Staub K....RA1hli F.J.	2016
50	FGF1 Mediates Overnutrition-Induced Compensatory I^-Cell Differentiation. ( 26420862 )	Li M....Chen W.	2015

Sources

Genes for Overnutrition

Genes related to Overnutrition (0 elite genes):

(show all 44)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	LEP	Leptin	Protein Coding	27.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	INS	Insulin	Protein Coding	27.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	FTO	FTO Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	25.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	AGRP	Agouti Related Neuropeptide	Protein Coding	24.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	23.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	FGF1	Fibroblast Growth Factor 1	Protein Coding	20.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CRAT	Carnitine O-Acetyltransferase	Protein Coding	20.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	19.89	DISEASES inferred ¹⁵
9	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	19.06	DISEASES inferred ¹⁵
10	UCP1	Uncoupling Protein 1	Protein Coding	19	DISEASES inferred ¹⁵
11	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	18.94	DISEASES inferred ¹⁵
12	MC4R	Melanocortin 4 Receptor	Protein Coding	18.84	DISEASES inferred ¹⁵
13	RETN	Resistin	Protein Coding	18.75	DISEASES inferred ¹⁵
14	LEPR	Leptin Receptor	Protein Coding	18.71	DISEASES inferred ¹⁵
15	CRP	C-Reactive Protein	Protein Coding	18.64	DISEASES inferred ¹⁵
16	NPY	Neuropeptide Y	Protein Coding	18.48	DISEASES inferred ¹⁵
17	IL6	Interleukin 6	Protein Coding	18.41	DISEASES inferred ¹⁵
18	PYY	Peptide YY	Protein Coding	18.06	DISEASES inferred ¹⁵
19	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	18.02	DISEASES inferred ¹⁵
20	GCG	Glucagon	Protein Coding	8.07	DISEASES inferred ¹⁵
21	TNF	Tumor Necrosis Factor	Protein Coding	8	DISEASES inferred ¹⁵
22	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	7.95	DISEASES inferred ¹⁵
23	UCP2	Uncoupling Protein 2	Protein Coding	7.87	DISEASES inferred ¹⁵
24	IRS1	Insulin Receptor Substrate 1	Protein Coding	7.85	DISEASES inferred ¹⁵
25	POMC	Proopiomelanocortin	Protein Coding	7.82	DISEASES inferred ¹⁵
26	FABP4	Fatty Acid Binding Protein 4	Protein Coding	7.81	DISEASES inferred ¹⁵
27	FGF21	Fibroblast Growth Factor 21	Protein Coding	7.79	DISEASES inferred ¹⁵
28	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	7.76	DISEASES inferred ¹⁵
29	UCP3	Uncoupling Protein 3	Protein Coding	7.75	DISEASES inferred ¹⁵
30	IGF1	Insulin Like Growth Factor 1	Protein Coding	7.75	DISEASES inferred ¹⁵
31	APOB	Apolipoprotein B	Protein Coding	7.68	DISEASES inferred ¹⁵
32	CNR1	Cannabinoid Receptor 1	Protein Coding	7.67	DISEASES inferred ¹⁵
33	SHBG	Sex Hormone Binding Globulin	Protein Coding	7.66	DISEASES inferred ¹⁵
34	SERPINE1	Serpin Family E Member 1	Protein Coding	7.65	DISEASES inferred ¹⁵
35	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	7.61	DISEASES inferred ¹⁵
36	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	7.57	DISEASES inferred ¹⁵
37	COG2	Component Of Oligomeric Golgi Complex 2	Protein Coding	7.56	DISEASES inferred ¹⁵
38	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	7.56	DISEASES inferred ¹⁵
39	ADRB3	Adrenoceptor Beta 3	Protein Coding	7.53	DISEASES inferred ¹⁵
40	HSD11B1	Hydroxysteroid 11-Beta Dehydrogenase 1	Protein Coding	7.49	DISEASES inferred ¹⁵
41	PLIN1	Perilipin 1	Protein Coding	7.46	DISEASES inferred ¹⁵
42	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	7.44	DISEASES inferred ¹⁵
43	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	7.44	DISEASES inferred ¹⁵
44	PNPLA2	Patatin Like Phospholipase Domain Containing 2	Protein Coding	7.4	DISEASES inferred ¹⁵

Sources

Variations for Overnutrition

Sources

Expression for Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Sources

Pathways for Overnutrition

Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁷ Show member pathways Alzheimer disease ³⁸ Alzheimers Disease ¹ Complex I biogenesis ⁶⁷ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁷ Huntington disease ³⁸ Non-alcoholic fatty liver disease (NAFLD) ³⁸ Oxidative phosphorylation ³⁸ Oxidative phosphorylation ¹ Parkinson disease ³⁸ Respiratory electron transport ⁶⁷ The citric acid (TCA) cycle and respiratory electron transport ⁶⁷ Thermogenesis ³⁸	13.41	ADIPOQ GCG IL6 INS LEP LEPR
2	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁶ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁶ Development Thrombopoietin-regulated cell processes ²³ IL-15 Signaling Pathways ⁶⁶ IL-2 Signaling Pathways ⁶⁶ IL-21 Signaling Pathways ⁶⁶ IL-4 Signaling Pathways ⁶⁶ IL-7 Signaling Pathways ⁶⁶ IL-9 Pathway ⁶⁵ IL-9 Signaling Pathways ⁶⁶ Immune response IL-9 signaling pathway ²³	12.65	ADIPOQ IL6 INS LEP RETN SOCS3
3	Prolactin Signaling Pathway ¹ ³⁸ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.34	INS LEP LEPR SOCS3
4	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁸ AMPK Signaling Pathway ⁶⁸	12.3	ADIPOQ INS LEP LEPR PPARG SREBF1
5	Glucose / Energy Metabolism ⁴	12.29	ADIPOQ FTO GCG INS PPARG SREBF1
6	JAK-STAT signaling pathway (KEGG) ⁶⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁷ JAK-STAT signaling pathway ³⁸	12.26	IL6 LEP LEPR SOCS3
7	Peptide hormone metabolism ⁶⁷ Show member pathways Glycoprotein hormones ⁶⁷ Insulin processing ⁶⁷ Metabolism of Angiotensinogen to Angiotensins ⁶⁷ Peptide hormone biosynthesis ⁶⁷ Synthesis, secretion, and deacylation of Ghrelin ⁶⁷	12.11	GCG GHRL INS LEP
8	Circadian rythm related genes ¹	12.02	ADIPOQ AGRP GHRL IL6 LEP PPARG
9	Insulin resistance ³⁸ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.85	IL6 INS SOCS3 SREBF1
10	Type II diabetes mellitus ³⁸ ¹ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶²	11.74	ADIPOQ INS SOCS3
11	PPAR signaling pathway ³⁸	11.62	ADIPOQ PPARG UCP1
12	Sterol Regulatory Element-Binding Proteins (SREBP) signalling ¹	11.61	INS PPARG SREBF1
13	ATF-2 transcription factor network ¹	11.45	IL6 INS SOCS3
14	Signaling events mediated by PTP1B ¹	11.43	INS LEP LEPR SOCS3
15	Adipogenesis ¹	11.4	ADIPOQ IL6 INS LEP PPARG RETN
16	Differentiation Pathway ¹	11.38	FGF1 IL6 INS
17	Adipocytokine signaling pathway ³⁸	11.27	ADIPOQ AGRP LEP LEPR NPY SOCS3
18	Development_Leptin signaling via JAK/STAT and MAPK cascades ²³ Show member pathways phospho-PLA2 pathway ⁶⁷	11.15	CRP LEP LEPR SOCS3
19	Differentiation of white and brown adipocyte ¹	11.05	ADIPOQ LEP PPARG
20	Transcription factor regulation in adipogenesis ¹	10.97	ADIPOQ IL6 LEP PPARG
21	Syndecan-3-mediated signaling events ¹	10.84	AGRP MC4R
22	FTO Obesity Variant Mechanism ¹	10.46	FTO UCP1

Sources

GO Terms for Overnutrition

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.77	ADIPOQ AGRP CRP FGF1 GCG GHRL
2	endoplasmic reticulum lumen	GO:0005788	9.46	GCG GHRL IL6 INS
3	extracellular space	GO:0005615	9.4	ADIPOQ AGRP CRP FGF1 GCG GHRL

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 46)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of inflammatory response	GO:0050728	9.86	ADIPOQ GHRL SOCS3
2	neuropeptide signaling pathway	GO:0007218	9.86	AGRP NPY PYY
3	cellular response to insulin stimulus	GO:0032869	9.85	ADIPOQ PPARG SREBF1
4	circadian rhythm	GO:0007623	9.85	ADIPOQ AGRP LEP SREBF1
5	cholesterol metabolic process	GO:0008203	9.84	LEP LEPR SREBF1
6	response to nutrient	GO:0007584	9.84	ADIPOQ LEP PPARG
7	response to insulin	GO:0032868	9.84	AGRP LEP MC4R RETN
8	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.82	IL6 LEP SOCS3
9	regulation of insulin secretion	GO:0050796	9.81	GCG LEP SREBF1
10	regulation of blood pressure	GO:0008217	9.8	LEP NPY PPARG
11	glucose metabolic process	GO:0006006	9.8	ADIPOQ GHRL INS LEP
12	hormone-mediated signaling pathway	GO:0009755	9.77	AGRP GHRL PPARG
13	glucose homeostasis	GO:0042593	9.77	ADIPOQ INS LEP LEPR PPARG
14	response to nutrient levels	GO:0031667	9.76	ADIPOQ GHRL LEP UCP1
15	acute-phase response	GO:0006953	9.74	CRP IL6 INS
16	negative regulation of collagen biosynthetic process	GO:0032966	9.7	IL6 PPARG
17	positive regulation of cellular protein metabolic process	GO:0032270	9.7	ADIPOQ INS
18	energy reserve metabolic process	GO:0006112	9.7	LEP LEPR MC4R
19	positive regulation of insulin receptor signaling pathway	GO:0046628	9.69	INS LEP
20	regulation of fat cell differentiation	GO:0045598	9.69	LEP PPARG
21	fatty acid oxidation	GO:0019395	9.69	ADIPOQ PPARG
22	negative regulation of gluconeogenesis	GO:0045721	9.69	ADIPOQ INS LEPR
23	interleukin-6-mediated signaling pathway	GO:0070102	9.68	IL6 SOCS3
24	central nervous system neuron development	GO:0021954	9.67	LEP NPY
25	sexual reproduction	GO:0019953	9.66	LEP LEPR
26	negative regulation of blood vessel diameter	GO:0097756	9.65	CRP INS
27	leptin-mediated signaling pathway	GO:0033210	9.65	LEP LEPR
28	positive regulation of cholesterol biosynthetic process	GO:0045542	9.65	FGF1 SREBF1
29	negative regulation of macrophage derived foam cell differentiation	GO:0010745	9.65	ADIPOQ CRP PPARG
30	positive regulation of cold-induced thermogenesis	GO:0120162	9.65	ADIPOQ GHRL LEP LEPR UCP1
31	diet induced thermogenesis	GO:0002024	9.63	MC4R UCP1
32	negative regulation of acute inflammatory response	GO:0002674	9.62	INS PPARG
33	positive regulation of feeding behavior	GO:2000253	9.61	AGRP GHRL
34	regulation of bone remodeling	GO:0046850	9.61	LEP LEPR
35	regulation of feeding behavior	GO:0060259	9.61	AGRP LEPR MC4R
36	regulation of brown fat cell differentiation	GO:0090335	9.59	FTO LEP
37	regulation of metabolic process	GO:0019222	9.58	LEP MC4R
38	positive regulation of appetite	GO:0032100	9.58	GHRL NPY
39	negative regulation of lipid storage	GO:0010888	9.58	CRP IL6 LEP
40	bone growth	GO:0098868	9.56	LEP LEPR
41	negative regulation of feeding behavior	GO:2000252	9.5	INS MC4R RETN
42	adult feeding behavior	GO:0008343	9.46	AGRP GHRL LEP NPY
43	regulation of signaling receptor activity	GO:0010469	9.36	ADIPOQ AGRP FGF1 GCG GHRL IL6
44	feeding behavior	GO:0007631	9.35	AGRP GCG MC4R NPY PYY
45	G protein-coupled receptor signaling pathway	GO:0007186	10.18	GCG GHRL INS MC4R NPY PPARG
46	negative regulation of apoptotic process	GO:0043066	10.08	GCG GHRL IL6 LEP SOCS3

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor binding	GO:0001664	9.43	GHRL NPY PYY
2	signaling receptor binding	GO:0005102	9.43	ADIPOQ AGRP CRAT GCG LEP NPY
3	neuropeptide hormone activity	GO:0005184	9.33	AGRP NPY PYY
4	hormone activity	GO:0005179	9.23	ADIPOQ GCG GHRL INS LEP NPY

Sources

Sources for Overnutrition

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia