Categories: Metabolic diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Overnutrition

MalaCards integrated aliases for Overnutrition:

Name: Overnutrition 11 43 14 71 75


External Ids:

Disease Ontology 11 DOID:654
MeSH 43 D044343
SNOMED-CT 68 302872003
UMLS 71 C1257763

Summaries for Overnutrition

Disease Ontology: 11 A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content.

MalaCards based summary: Overnutrition is related to body mass index quantitative trait locus 11 and leptin deficiency or dysfunction. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Adipogenesis and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Betahistine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include breast, liver and skeletal muscle, and related phenotypes are hematopoietic system and integument

Wikipedia: 75 Overnutrition (also known as hyperalimentation) is a form of malnutrition in which the intake of... more...

Related Diseases for Overnutrition

Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 391)
# Related Disease Score Top Affiliating Genes
1 body mass index quantitative trait locus 11 32.4 SOCS3 SERPINA3 MIR34A MIR29A MIR21 MIR199A1
2 leptin deficiency or dysfunction 31.6 SOCS3 LEP INS FTO AGRP ADIPOQ
3 nutritional deficiency disease 31.6 SERPINA3 LEP H2AC18 CCR6 ADIPOQ
4 type 2 diabetes mellitus 31.5 SOCS3 SERPINA3 MIR34A MIR29A MIR21 MIR199A1
5 abdominal obesity-metabolic syndrome 1 31.5 MIR122 LEP INS ADIPOQ
6 non-alcoholic fatty liver disease 31.5 MIR34A MIR21 MIR17 MIR126 MIR122 LEP
7 glucose intolerance 31.3 LEP INS FTO ADIPOQ
8 bone disease 31.3 SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR155
9 fatty liver disease 31.2 MIR34A MIR29A MIR21 MIR155 MIR122 LEP
10 hyperglycemia 31.1 MIR126 LEP INS ADIPOQ
11 prediabetes syndrome 31.0 MIR29A MIR21 MIR126 LEP INS ADIPOQ
12 lipid metabolism disorder 31.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR126 LEP
13 non-alcoholic steatohepatitis 31.0 MIR34A MIR21 MIR199A1 MIR122 LEP INS
14 adult syndrome 31.0 LEP INS H2AC18 ADIPOQ
15 diabetes mellitus 30.9 SOCS3 SERPINA3 MIR34A MIR29A MIR21 MIR17
16 liver disease 30.8 SERPINA3 MIR34A MIR21 MIR155 MIR122 LEP
17 colonic benign neoplasm 30.6 SERPINA3 MIR21 MIR199A1 INS H2AC18 CCR6
18 cerebrovascular disease 30.6 SERPINA3 MIR29A MIR21 MIR199A1 MIR17 MIR155
19 toxic encephalopathy 30.6 SERPINA3 MIR29A MIR126 H2AC18 CCR6
20 respiratory failure 30.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR126
21 kidney cancer 30.6 MIR29A MIR21 MIR199A1 MIR17 MIR126 MIR122
22 lymphoma, non-hodgkin, familial 30.6 SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR155
23 acanthosis nigricans 30.5 LEP INS ADIPOQ
24 pancreatic cancer 30.5 SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR155
25 lymphoma, hodgkin, classic 30.5 MIR21 MIR155 H2AC18 CCR6
26 endometrial cancer 30.5 MIR21 MIR199A1 LEP INS H2AC18 FGF1
27 colorectal cancer 30.4 SOCS3 SERPINA3 MIR34A MIR29A MIR21 MIR199A1
28 familial hyperlipidemia 30.3 LEP INS ADIPOQ
29 hypervitaminosis a 11.0
30 hypervitaminosis d 11.0
31 vascular disease 10.6 MIR21 MIR199A1 MIR126 LEP INS ADIPOQ
32 eating disorder 10.6 LEP INS H2AC18 FTO AGRP
33 myopathy 10.6 SERPINA3 MIR21 MIR199A1 MIR126 INS H2AC18
34 autoimmune disease of endocrine system 10.6 MIR21 LEP INS H2AC18 CCR6
35 thyroid gland disease 10.6 MIR199A1 MIR17 LEP INS H2AC18 CCR6
36 muscle tissue disease 10.6 SERPINA3 MIR21 MIR199A1 MIR126 INS H2AC18
37 autoimmune disease of gastrointestinal tract 10.6 SERPINA3 MIR21 MIR199A1 MIR126 MIR122 INS
38 bacterial infectious disease 10.6 SERPINA3 MIR21 MIR155 H2AC18 CCR6
39 cervix carcinoma 10.6 SERPINA3 MIR21 MIR199A1 H2AC18 FTO CCR6
40 gastrointestinal system benign neoplasm 10.6 SERPINA3 MIR21 MIR199A1 MIR17 INS H2AC18
41 placenta disease 10.6 SERPINA3 MIR199A1 INS H2AC18 CCR6 ADIPOQ
42 alcohol use disorder 10.6 SERPINA3 MIR29A MIR199A1 INS H2AC18 CCR6
43 peripheral artery disease 10.6 MIR21 MIR199A1 MIR17 MIR126 INS
44 retinal vascular disease 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR126 INS
45 chronic fatigue syndrome 10.6 SERPINA3 MIR126 INS H2AC18 CCR6
46 substance abuse 10.6 SERPINA3 MIR199A1 INS H2AC18 CCR6
47 bone resorption disease 10.6 MIR199A1 MIR17 MIR126 MIR122 INS H2AC18
48 extrinsic cardiomyopathy 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR126 H2AC18
49 muscular disease 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR126 INS
50 bone remodeling disease 10.6 SERPINA3 MIR199A1 MIR17 MIR126 MIR122 INS

Graphical network of the top 20 diseases related to Overnutrition:

Diseases related to Overnutrition

Symptoms & Phenotypes for Overnutrition

MGI Mouse Phenotypes related to Overnutrition:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 ADIPOQ BCL10 CCR6 FGF1 INS LEP
2 integument MP:0010771 9.28 ADIPOQ FTO INS LEP MIR126 MIR29A

Drugs & Therapeutics for Overnutrition

Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Betahistine Approved, Investigational Phase 1 5638-76-6 2366
Histamine Approved, Investigational Phase 1 51-45-6 774
3 Neurotransmitter Agents Phase 1
4 Vasodilator Agents Phase 1
Histamine phosphate Phase 1 51-74-1 134614
Iron Approved 7439-89-6 29936
Zinc cation Approved, Experimental, Investigational 7440-66-6, 23713-49-7 32051
Ethanol Approved Early Phase 1 64-17-5 702
9 Coconut Approved Early Phase 1
10 Strawberry Approved Early Phase 1
Silicon Approved, Investigational Early Phase 1 7440-21-3 4082203
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
Tannic acid Approved 1401-55-4 16129878 16129778
Diamorphine Approved, Illicit, Investigational 561-27-3 5462328
Rosemary Experimental Early Phase 1
16 Vitamins
17 Omega 3 Fatty Acid
18 Soy Bean Early Phase 1
19 Trace Elements
20 Micronutrients

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Pilot Study of the Metabolic Effects of Betahistine Hydrochloride in Overweight Women Completed NCT00459992 Phase 1 Betahistine Hydrochloride
2 Association of Early Life Nutritional Related Exposures and Long-term Health and Cognitive Development Outcomes in Adolescents in Northeast, Thailand Unknown status NCT01979770
3 Energy Expenditure and Sleep in Response to Protein/Carbohydrate and Fat Ratio Unknown status NCT01551238
4 Attenuating the Micronutrient Malnutrition of Overnutrition (AMMO) Completed NCT02239198
5 Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness Completed NCT01224561
6 Clinical Investigation on the Safety of Avocado Pulp Lipids Completed NCT03898505 Early Phase 1
7 A Psychoeducational Intervention Model in Nutrition to Improve Nutritional Status in a Pilot Low Resource Population in the City of Saltillo, Coahuila Mexico. Completed NCT02258802
8 ChildObesity180 - Social Marketing Campaign to Encourage Healthful Eating in Restaurants for Children Completed NCT03422926
9 Community Translation of a Lifestyle Intervention to Improve Health in Diabetes Completed NCT01435603
10 A Psychoeducational Intervention Model in Nutrition to Improve Nutritional Status in 15 Low Resource Populations Through a Network of Food Banks in Mexico. Completed NCT02914002
11 Healthy Babies Through Infant Centered Feeding Completed NCT01816516
12 The Effect of in Utero Hyperglycaemia, Maternal Overnutrition and Interaction With Postnatal Lifestyle on Cardiometabolic Risk at Young Adulthood - Extension of HAPO Follow-up Study Recruiting NCT05477511
13 Korean OBEsity Surgical Treatment Study(KOBESS-II) : Protocol of a Prospective Multicenter Cohort Study on Morbid Obesity Patients Undergoing Sleeve Gastrectomy Versus Roux-en Y Gastric Bypass Recruiting NCT04554758
14 Measurement of Energy Metabolism in Infants: BabyEE Pilot Recruiting NCT02683473
15 A Pragmatic Family-Centered Approach to Childhood Obesity Treatment Recruiting NCT03843424
16 The Food Intake Phenotype: Assessing Eating Behavior and Food Preferences as Risk Factors for Obesity Recruiting NCT00342732
17 IMplementation and Evaluation of the School-based Family Support PRogramme A Healthy School Start to Promote Child Health and Prevent OVErweight and Obesity (IMPROVE) - Study Protocol for a Cluster-randomized Trial Recruiting NCT04984421
18 Maternal Obesity, Breast Milk Composition, and Infant Growth Active, not recruiting NCT03301753
19 Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care Active, not recruiting NCT03003403
20 The FEASST Study: Food Intake and Epigenetic Alteration in the Spermatozoa of Singletons and Twins Active, not recruiting NCT05368194
21 Intervening in Food Insecurity to Reduce and Mitigate (InFoRM) Childhood Obesity Not yet recruiting NCT05586269
22 Effect of Double Duty Interventions on Double Burden of Malnutrition, Dietary Diversity Score, and Frequency of Morbidity Among Secondary School Adolescents in Central Ethiopia: Cluster Randomized Controlled Trial Not yet recruiting NCT05574842
23 Measuring the Effectiveness of Eatable Alphabet Cards as a Nutrition Education Tool in a Pediatric Weight Management Program Not yet recruiting NCT05166629

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

Genetic Tests for Overnutrition

Anatomical Context for Overnutrition

Organs/tissues related to Overnutrition:

MalaCards : Breast, Liver, Skeletal Muscle, Brain, Adipocyte, Thyroid, Pancreatic Islet

Publications for Overnutrition

Articles related to Overnutrition:

(show top 50) (show all 1814)
# Title Authors PMID Year
Sensitization of Hypertension: The Impact of Earlier Life Challenges: Excellence Award for Hypertension Research 2021. 62
36069195 2023
Secular trend for increasing birthweight in offspring of pregnant women with type 1 diabetes: is improved placentation the reason? 62
36287249 2023
Progression from prediabetes to type 2 diabetes mellitus induced by overnutrition. 62
36197636 2022
DNA hypermethylation of Kiss1r promoter and reduction of hepatic Kiss1r in female rats with type 2 diabetes. 62
36094166 2022
Comparison between obese and non-obese NAFLD. 62
36472052 2022
Maternal soybean diet on prevention of obesity-related breast cancer through early-life gut microbiome and epigenetic regulation. 62
35933021 2022
Protective effect of antioxidants on cardiac function in adult offspring exposed to prenatal overnutrition. 62
35272740 2022
Fetal programming in sheep: Effects on pre- and postnatal organs and glands development in lambs. 62
35878535 2022
Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles. 62
35880782 2022
Maternal programming by high-energy diets primes ghrelin sensitivity in the offspring of rats exposed to chronic immobilization stress. 62
36174387 2022
Impact of obesity and diet on brain structure and function: a gut-brain-body crosstalk. 62
36345149 2022
Nutrition in school-age children: a rationale for revisiting priorities. 62
36346900 2022
HGFAC is a ChREBP regulated hepatokine that enhances glucose and lipid homeostasis. 62
36413406 2022
Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated with Progressive Dysglycemia and Risk of Complications. 62
36446741 2022
Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women. 62
35286051 2022
Comparison of Weight-for-height and BMI-for-Age for Estimating Overnutrition Burden in Under-five Populations With High Stunting Prevalence. 62
36415115 2022
High fat diet-induced hyperlipidemia and tissue steatosis in rabbits through modulating ileal microbiota. 62
36173452 2022
School water, sanitation, and hygiene (WaSH) intervention to improve malnutrition, dehydration, health literacy, and handwashing: a cluster-randomised controlled trial in Metro Manila, Philippines. 62
36344973 2022
Prevalence of malnutrition among old people in Africa: systematic review and meta-analysis. 62
36450428 2022
Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease. 62
34510753 2022
Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition. 62
36122525 2022
PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition. 62
36055580 2022
The immediate effect of overnutrition and fluoxetine treatment during the critical period of development on the hippocampus. 62
36462683 2022
Hawthorn or semen cassiae-alleviated high-fat diet-induced hepatic steatosis in rats via the reduction of endoplasmic reticulum stress. 62
36326424 2022
[Cross-Sectional Study of Nutritional Status and Dietary Nutrient Intake in Children with Duchenne Muscular Dystrophy (DMD) in China]. 62
36443054 2022
Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions. 62
36098211 2022
Prenatal programming of developmental trajectories for obesity risk and early pubertal timing. 62
35727305 2022
Long-term changes in the diurnal temporal regulation and set points of metabolic parameters associated with chronic maternal overnutrition in rabbits. 62
36288336 2022
Physical growth and sexual maturation of perinatally HIV-infected adolescent males in a southeast Nigerian tertiary hospital: a comparative cross-sectional study. 62
36199047 2022
Trend of Ultraprocessed Product Intake Is Associated with the Double Burden of Malnutrition in Mexican Children and Adolescents. 62
36297032 2022
In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status. 62
36222100 2022
Double burden of malnutrition in ethnic minority school-aged children living in mountainous areas of Vietnam and its association with nutritional behavior. 62
36238380 2022
Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex. 62
36261001 2022
Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation. 62
35917736 2022
Prepartum dietary energy intake alters hepatic expression of genes related to peroxisome proliferator-activated receptor and inflammation in peripartal dairy cows. 62
36028348 2022
Silencing of hypothalamic FGF11 prevents diet-induced obesity. 62
36064426 2022
Lysosome Inhibition Reduces Basal and Nutrient-Induced Fat Accumulation in Caenorhabditis elegans. 62
36058890 2022
Nutritional assessment and dietetic resource for children and young people with cancer in the United Kingdom. 62
35484958 2022
Adipose Tissue Dysfunction: Impact on Metabolic Changes? 62
35952684 2022
Effect of pre-conceptional nutrition and season on fetal growth during early pregnancy in sheep. 62
35914348 2022
Lipidomics in nutrition research. 62
35788540 2022
Diarrhoea, malnutrition, and dehydration associated with school water, sanitation, and hygiene in Metro Manila, Philippines: A cross-sectional study. 62
35568174 2022
TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis. 62
36171419 2022
Lactation overnutrition-induced obesity impairs effects of exogenous corticosterone on energy homeostasis and hypothalamic-pituitary-adrenal axis in male rats. 62
35716735 2022
Quantity and Source of Protein during Complementary Feeding and Infant Growth: Evidence from a Population Facing Double Burden of Malnutrition. 62
36235599 2022
Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis. 62
35358616 2022
Positive or U-Shaped Association of Elevated Hemoglobin Concentration Levels with Metabolic Syndrome and Metabolic Components: Findings from Taiwan Biobank and UK Biobank. 62
36235661 2022
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. 62
35777200 2022
The Related Metabolic Diseases and Treatments of Obesity. 62
36141228 2022
Adverse perinatal conditions and the developmental origins of thyroid dysfunction-Lessons from Animal Models. 62
36036880 2022

Variations for Overnutrition

Expression for Overnutrition

Search GEO for disease gene expression data for Overnutrition.

Pathways for Overnutrition

GO Terms for Overnutrition

Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 10 MIR29A MIR21 MIR199A1 MIR17 MIR155 MIR126
2 extracellular space GO:0005615 9.91 SERPINA3 MIR29A MIR21 MIR199A1 MIR17 MIR126
3 extracellular vesicle GO:1903561 9.1 MIR34A MIR29A MIR21 MIR17 MIR126 MIR122

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.19 MIR34A MIR29A MIR21 MIR17 INS FGF1
2 negative regulation of inflammatory response GO:0050728 10.03 ADIPOQ MIR126 MIR199A1 SOCS3
3 miRNA-mediated gene silencing GO:0035195 10 MIR122 MIR126 MIR155 MIR17 MIR199A1 MIR21
4 fatty acid beta-oxidation GO:0006635 9.98 LEP CRAT ADIPOQ
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.97 MIR21 MIR126 LEP INS
6 activation of protein kinase B activity GO:0032148 9.92 MIR21 INS FGF1
7 negative regulation of cell migration GO:0030336 9.91 MIR34A MIR29A MIR21 MIR126 ADIPOQ
8 positive regulation of cytokine production GO:0001819 9.85 BCL10 INS LEP MIR21
9 positive regulation of angiogenesis GO:0045766 9.85 MIR29A MIR21 MIR199A1 MIR126 FGF1
10 regulation of brown fat cell differentiation GO:0090335 9.84 LEP FTO
11 positive regulation of endothelial cell migration GO:0010595 9.8 MIR29A MIR21 MIR199A1 FGF1
12 negative regulation of cartilage development GO:0061037 9.78 MIR21 LEP
13 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.78 MIR34A MIR21 ADIPOQ
14 positive regulation of vascular endothelial cell proliferation GO:1905564 9.69 MIR29A MIR21 MIR126
15 positive regulation of connective tissue replacement GO:1905205 9.6 MIR34A MIR199A1
16 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.58 MIR199A1 MIR17
17 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.57 MIR21 MIR17
18 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.56 MIR29A MIR21 MIR17 MIR126
19 negative regulation of gene expression GO:0010629 9.56 MIR34A MIR29A MIR21 MIR199A1 MIR17 MIR155
20 positive regulation of metalloendopeptidase activity GO:1904685 9.55 MIR17 MIR21
21 negative regulation of vascular endothelial growth factor production GO:1904046 9.5 MIR34A MIR199A1 MIR17
22 positive regulation of protein kinase B signaling GO:0051897 9.23 MIR29A MIR21 MIR199A1 MIR126 LEP INS

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.5 MIR34A MIR29A MIR21 MIR199A1 MIR17 MIR155
2 mRNA base-pairing translational repressor activity GO:1903231 9.17 MIR34A MIR29A MIR21 MIR199A1 MIR17 MIR155

Sources for Overnutrition

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
Loading form....