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MCID: OVR063
MIFTS: 53

Overnutrition

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Overnutrition

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MalaCards integrated aliases for Overnutrition:

Name: Overnutrition 12 45 15 74

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:654
MeSH 45 D044343
UMLS 74 C1257763
Sources

Summaries for Overnutrition

About this section
Disease Ontology : 12 A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content.

MalaCards based summary : Overnutrition is related to nutritional deficiency disease and body mass index quantitative trait locus 11. An important gene associated with Overnutrition is LEP (Leptin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Aspirin and Moxonidine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and bone, and related phenotypes are homeostasis/metabolism and adipose tissue

Wikipedia : 77 Overnutrition or hyperalimentation is a form of malnutrition in which the intake of nutrients is... more...

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Related Diseases for Overnutrition

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Diseases related to Overnutrition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 nutritional deficiency disease 32.3 CRP GHRL IL6 LEP
2 body mass index quantitative trait locus 11 31.4 ADIPOQ AGRP CRP FTO GCG GHRL
3 gestational diabetes 30.9 ADIPOQ INS LEP RETN
4 liver disease 30.6 ADIPOQ IL6 INS LEP LEPR
5 fatty liver disease, nonalcoholic 1 30.6 ADIPOQ INS LEP RETN SREBF1
6 lipid metabolism disorder 30.5 ADIPOQ CRP INS LEP PPARG RETN
7 fatty liver disease 30.4 ADIPOQ IL6 INS LEP LEPR SREBF1
8 diabetes mellitus, noninsulin-dependent 30.3 ADIPOQ CRP GCG GHRL IL6 INS
9 glucose intolerance 30.1 ADIPOQ CRP GCG GHRL INS LEP
10 hypervitaminosis a 11.4
11 hypervitaminosis d 11.1
12 lipodystrophy, familial partial, type 1 10.5 INS LEP PPARG
13 complete generalized lipodystrophy 10.5 INS LEP PPARG
14 lipodystrophy, congenital generalized, type 1 10.5 ADIPOQ INS LEP
15 nonalcoholic steatohepatitis 10.5 ADIPOQ INS LEP
16 idiopathic recurrent pericarditis 10.5 ADIPOQ LEP RETN
17 malignant otitis externa 10.5 CRP INS
18 endocrine pancreas disease 10.5 ADIPOQ INS LEP
19 idiopathic edema 10.5 ADIPOQ INS PPARG
20 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.5 INS LEP
21 familial partial lipodystrophy 10.5 INS LEP PPARG
22 type 1 diabetes mellitus 15 10.5 GCG INS
23 abdominal obesity-metabolic syndrome 1 10.5 ADIPOQ INS LEP PPARG
24 hypercholesterolemia, autosomal recessive 10.5 AGRP LEP NPY
25 coronary artery aneurysm 10.5 ADIPOQ LEP RETN
26 anovulation 10.5 CRP INS LEP
27 acanthosis nigricans 10.5 ADIPOQ INS LEP PPARG
28 cold agglutinin disease 10.5 CRP IL6
29 severe pre-eclampsia 10.5 ADIPOQ LEP LEPR
30 autoimmune myocarditis 10.5 IL6 PPARG
31 dumping syndrome 10.5 GCG INS PYY
32 obesity-hypoventilation syndrome 10.5 ADIPOQ IL6 LEP RETN
33 hyperinsulinemic hypoglycemia, familial, 7 10.5 GCG INS
34 sleep disorder 10.5 CRP IL6 INS LEP
35 postgastrectomy syndrome 10.5 INS PYY
36 nonalcoholic fatty liver disease 10.5 ADIPOQ INS LEP SREBF1
37 uremia 10.5 CRP INS LEP RETN
38 hyperthyroidism 10.5 GHRL INS LEP
39 lipid storage disease 10.5 ADIPOQ INS SREBF1
40 intermittent explosive disorder 10.4 CRP IL6 NPY
41 acute insulin response 10.4 CRP GCG INS UCP1
42 acquired generalized lipodystrophy 10.4 ADIPOQ INS LEP PPARG RETN
43 end stage renal failure 10.4 CRP IL6 LEP
44 maturity-onset diabetes of the young, type 9 10.4 GCG INS
45 cryopyrin-associated periodic syndrome 10.4 CRP IL6
46 urinary system disease 10.4 CRP IL6 INS
47 cerebrovascular disease 10.4 ADIPOQ CRP IL6 INS
48 apnea, obstructive sleep 10.4 ADIPOQ CRP IL6 INS LEP
49 hypercholesterolemia, familial 10.4 AGRP CRP INS NPY
50 hyperglycemia 10.4 ADIPOQ GCG INS LEP PPARG

Graphical network of the top 20 diseases related to Overnutrition:



Diseases related to Overnutrition
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Symptoms & Phenotypes for Overnutrition

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MGI Mouse Phenotypes related to Overnutrition:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 ADIPOQ AGRP CRAT CRP FGF1 FTO
2 adipose tissue MP:0005375 10.42 ADIPOQ AGRP FTO GHRL IL6 INS
3 behavior/neurological MP:0005386 10.35 ADIPOQ AGRP FTO GHRL IL6 INS
4 growth/size/body region MP:0005378 10.34 ADIPOQ AGRP CRAT FTO IL6 INS
5 cardiovascular system MP:0005385 10.22 ADIPOQ CRAT CRP IL6 INS LEP
6 liver/biliary system MP:0005370 10.22 ADIPOQ AGRP FTO IL6 INS LEP
7 immune system MP:0005387 10.2 ADIPOQ CRP FTO IL6 INS LEP
8 digestive/alimentary MP:0005381 10.05 GHRL IL6 INS LEP LEPR NPY
9 integument MP:0010771 10.03 ADIPOQ FTO IL6 INS LEP LEPR
10 nervous system MP:0003631 10 ADIPOQ AGRP FGF1 IL6 INS LEP
11 muscle MP:0005369 9.91 ADIPOQ CRAT IL6 INS LEP LEPR
12 normal MP:0002873 9.85 AGRP FGF1 GHRL INS LEPR MC4R
13 neoplasm MP:0002006 9.8 ADIPOQ IL6 LEP LEPR MC4R PPARG
14 renal/urinary system MP:0005367 9.56 ADIPOQ FTO IL6 INS LEP LEPR
15 skeleton MP:0005390 9.36 ADIPOQ FTO IL6 INS LEP LEPR
Sources

Drugs & Therapeutics for Overnutrition

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Drugs for Overnutrition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 665)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Early Phase 1 50-78-2 2244
2
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
4
Dalteparin Approved Phase 4,Phase 1 9005-49-6
5
Enoxaparin Approved Phase 4,Phase 1,Phase 2 9005-49-6 772
6
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
7
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 83150-76-9 6400441 383414
8
Rocuronium Approved Phase 4,Phase 2,Not Applicable 119302-91-9, 143558-00-3 441290
9
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
10
tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1401-55-4
11
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
12
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
13
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 15589840 11953898
14
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 2 13422-55-4
15
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
16
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
17
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198
18
Irbesartan Approved, Investigational Phase 4,Not Applicable 138402-11-6 3749
19
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
20
Coal tar Approved Phase 4,Phase 1,Phase 2 8007-45-2
21
Saxagliptin Approved Phase 4 361442-04-8 11243969
22
Nadroparin Approved, Investigational Phase 4
23
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 46507594 772
24
Anastrozole Approved, Investigational Phase 4,Not Applicable 120511-73-1 2187
25
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 141758-74-9 15991534
26
Acetaminophen Approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
27
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
28
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
29
Orlistat Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 96829-58-2 3034010
30
leucovorin Approved Phase 4,Not Applicable 58-05-9 143 6006
31
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable,Early Phase 1 7440-66-6 32051
32
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 437-38-7 3345
33
Remifentanil Approved Phase 4,Phase 2,Phase 3,Not Applicable 132875-61-7 60815
34
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Phase 3 28523-86-6 5206
35
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
36
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 64-17-5 702
37
Methylene blue Approved, Investigational Phase 4,Phase 1,Phase 2 61-73-4
38
Glycerol Approved, Investigational Phase 4,Not Applicable 56-81-5 753
39
Empagliflozin Approved Phase 4 864070-44-0
40
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
41
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
42
Topiramate Approved Phase 4,Phase 3,Phase 2,Not Applicable 97240-79-4 5284627
43
Phentermine Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 122-09-8 4771
44
Cefazolin Approved Phase 4,Not Applicable,Early Phase 1 25953-19-9 33255 656510
45
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
46
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
47
Tocopherol Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 1406-66-2 14986
48
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
49
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
50
Ursodeoxycholic acid Approved, Investigational Phase 4,Not Applicable 128-13-2 31401

Interventional clinical trials:

(show top 50) (show all 2540)
# Name Status NCT ID Phase Drugs
1 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
2 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
3 The Effect of Obesity in Dexmedetomidine Metabolic Clearance Unknown status NCT02557867 Phase 4 Dexmedetomidine
4 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
5 The Therapeutic Effect of Catgut Embedding in Obesity Unknown status NCT02276235 Phase 4
6 Prevention and Control of Obesity in Primary School Children in Tehran Unknown status NCT02082080 Phase 4
7 Anti Xa Levels Under Two Different Regimens of Enoxaparin VTE Prophylaxis After Sleeve Gastrectomy for Morbid Obesity Unknown status NCT01970202 Phase 4 40mg Enoxaparin;60mg Enoxaparin
8 Pharmacokinetics of Dexmedetomidine in Morbid Obesity Unknown status NCT01864187 Phase 4 Dexmedetomidine
9 Evaluation of the Effects of Laying Early a Gastric Band on the Prevention of Morbid Obesity Randomized Checked Against Standard Management of Obesity in This Population. Unknown status NCT01700738 Phase 4
10 Impact of the Preservation of the Gastric Antrum in the Technique of Sleeve Gastrectomy for the Treatment of the Morbid Obesity Unknown status NCT01550601 Phase 4
11 The Effect of Vitamin A Supplementation on Cytokine Profile in Obesity Unknown status NCT01405352 Phase 4
12 Effect of Bile Acids and Bile Acid Sequstrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass Unknown status NCT02952963 Phase 4 Chenodeoxycholic Acid;Colesevelam
13 Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass Unknown status NCT02876484 Phase 4 Colesevelam;Chenodeoxycholic Acid
14 Gut Hormones as Mediators of Different Weight Loss Responses After Roux-en-Y Gastric Bypass Unknown status NCT02374632 Phase 4
15 Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions Unknown status NCT02118844 Phase 4 rocuronium
16 VAS Correlation With BMI Unknown status NCT02017314 Phase 4 Morphine
17 Banded Versus Conventional Laparoscopic Roux-en-Y (GABY) Unknown status NCT01015469 Phase 4
18 Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy Unknown status NCT00667706 Phase 4
19 Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Unknown status NCT02438020 Phase 4 Metformin
20 Vitamin Deficiencies and Suppletion in Morbid Obesity Unknown status NCT02270749 Phase 4 Hydroxocobalamin;FitForMe vitamin B12
21 Effect of Laparoscopic Sleeve Gastrectomy in the Morbidly Obese, Kidney Transplant Candidate Unknown status NCT01913392 Phase 4
22 Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity Unknown status NCT00134303 Phase 4 Metformin
23 Effect of Acarbose and Vildagliptin on Visceral Fat Distribution in Newly Diagnosed Type 2 Diabetes Patients Unknown status NCT02999841 Phase 4 Acarbose;Vildagliptin
24 The Effect of Moxonidine on Blood Pressure and Regression of Early Target Organ Damage in Young Subjects With Abdominal Obesity and Hypertension Unknown status NCT01360710 Phase 4 Moxonidine;Irbesartan
25 Treatment of Periodontitis in Obese Individuals Unknown status NCT03103204 Phase 4
26 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
27 Prophylaxis of Venous Thromboembolism After Bariatric Surgery Unknown status NCT02295150 Phase 4 Nadroparin
28 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Unknown status NCT02959853 Phase 4 Anastrazole
29 Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging Completed NCT02833415 Phase 4 [U-13C3] glycerol;Empagliflozin;Placebo (for Empagliflozin)
30 Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers Completed NCT01090141 Phase 4 Micafungin;Micafungin
31 Bread in Overweight/Obesity Treatment Completed NCT01223989 Phase 4
32 BIFI-OBESE: Clinical Trial in Paediatric Obesity Completed NCT03261466 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
33 A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents Completed NCT02714062 Phase 4 Placebo;VI-0521 Mid Dose;VI-0521 Top Dose
34 Use of Metformin in Treatment of Childhood Obesity Completed NCT02274948 Phase 4 Metformin;Placebo
35 Auricular Acupuncture in the Treatment of Obesity Completed NCT02269371 Phase 4
36 GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men Completed NCT02170324 Phase 4 Exenatide;Placebo
37 Increased Cefazolin During Cesarean Delivery in Obese Population Completed NCT02049944 Phase 4 Cefazolin
38 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
39 Enoxaparin Dosing in Obesity Completed NCT01798550 Phase 4 Enoxaparin
40 Evaluation of a Commercial Gaming Impact in a Childhood Obesity Intervention Completed NCT01757925 Phase 4
41 Clinical Trial Between Laparoscopic Gastric Bypass and Laparoscopic Vertical Banded Gastroplasty for Morbid Obesity Completed NCT01639677 Phase 4
42 Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations Completed NCT01307930 Phase 4 Anidulafungin
43 A Randomized Clinical Trial of Home-based Exercise Combined With a Slight Caloric Restriction on Obesity Prevention Among Women Completed NCT01206413 Phase 4
44 Effect of Weight and/or Obesity on Caspofungin Drug Concentrations Completed NCT01062165 Phase 4 Caspofungin
45 Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs) Completed NCT00694811 Phase 4
46 Post Implantation/Post Market Evaluation of the Swedish Adjustable Gastric Band Completed NCT00543140 Phase 4
47 A Study of Octreotide Depot vs Saline Control in Pediatric Hypothalamic Obesity Patients Completed NCT00171613 Phase 4 Octreotide
48 Pediatric Hypothalamic Obesity Completed NCT00076362 Phase 4 Sandostatin LAR
49 Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia Completed NCT03358524 Phase 4 Vitamin E 400 UNT;Placebo oral capsule
50 Dosing Obese With Noxafil® Under a Trial (DONUT) Completed NCT03246386 Phase 4 Posaconazole Injection [Noxafil] 300mg;Posaconazole Injection [Noxafil] 400mg

Search NIH Clinical Center for Overnutrition

Cochrane evidence based reviews: overnutrition

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Genetic Tests for Overnutrition

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Anatomical Context for Overnutrition

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MalaCards organs/tissues related to Overnutrition:

42
Brain, Heart, Bone, Testes, Endothelial, Kidney, Pituitary
Sources

Publications for Overnutrition

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Articles related to Overnutrition:

(show top 50) (show all 252)
# Title Authors Year
1
Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice. ( 30842440 )
2019
2
Investigating Gene-Gene and Gene-Environment Interactions in the Association Between Overnutrition and Obesity-Related Phenotypes. ( 30886629 )
2019
3
Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons. ( 30951750 )
2019
4
Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches. ( 30966886 )
2019
5
Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs. ( 31061112 )
2019
6
Reuniting overnutrition and undernutrition, macronutrients, and micronutrients. ( 30171821 )
2019
7
UBE3A Suppresses Overnutrition-Induced Expression of the Steatosis Target Genes of MLL4 by Degrading MLL4. ( 30230575 )
2019
8
Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. ( 29956204 )
2018
9
Overnutrition and Scholastic Achievement: Is There a Relationship? An 8-Year Follow-Up Study. ( 30308520 )
2018
10
Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition. ( 30315171 )
2018
11
Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations. ( 30577472 )
2018
12
Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. ( 28940822 )
2018
13
Metformin influences on respiratory system in obese mice induced by postnatal overnutrition. ( 28963087 )
2018
14
Fetal Overnutrition and Adolescent Hepatic Fat Fraction: the Exploring Perinatal Outcomes in Children Study. ( 29046229 )
2018
15
The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent. ( 29077836 )
2018
16
Postnatal overnutrition affects metabolic and vascular function reflected by physiological and histological changes in the aorta of adult Wistar rats. ( 29115861 )
2018
17
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice. ( 29390923 )
2018
18
Prevalence and sociodemographic determinants of adult obesity: a large representative household survey in a resource-constrained African setting with double burden of undernutrition and overnutrition. ( 29599385 )
2018
19
Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin. ( 29632515 )
2018
20
Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone β-Subunit in Peripubertal Male Rats. ( 29706935 )
2018
21
Sociodemographic and geographical inequalities in under- and overnutrition among children and mothers in Bangladesh: a spatial modelling approach to a nationally representative survey. ( 29717690 )
2018
22
Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats. ( 29777232 )
2018
23
Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance. ( 29812971 )
2018
24
Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. ( 29972782 )
2018
25
Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring. ( 29991958 )
2018
26
Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring. ( 30027100 )
2018
27
A maternal low-protein diet and neonatal overnutrition result in similar changes to glomerular morphology and renal cortical oxidative stress measures in male Wistar rats. ( 30058348 )
2018
28
The transcriptome of the rat subfornical organ is altered in response to early postnatal overnutrition. ( 30135952 )
2018
29
Postnatal overnutrition alters the orexigenic effects of melanin-concentrating hormone (MCH) and reduces MCHR1 hypothalamic expression on spontaneous feeding and fasting. ( 30196088 )
2018
30
Overnutrition: Does Complementary Feeding Play a Role? ( 30196296 )
2018
31
Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. ( 30226474 )
2018
32
Effect of maternal antioxidant supplementation and/or exercise practice during pregnancy on postnatal overnutrition induced by litter size reduction: Brain redox homeostasis at weaning. ( 30232036 )
2018
33
Maternal Nutrition during Pregnancy Affects Testicular and Bone Development, Glucose Metabolism and Response to Overnutrition in Weaned Horses Up to Two Years. ( 28081146 )
2017
34
Placental Lipid and Fatty Acid Transfer in Maternal Overnutrition. ( 28301855 )
2017
35
Exacerbation of liver steatosis following exposure to famine and overnutrition. ( 28499082 )
2017
36
Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters. ( 28527530 )
2017
37
Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. ( 28594364 )
2017
38
Fetal overnutrition and offspring insulin resistance and β-cell function: the Exploring Perinatal Outcomes among Children (EPOCH) study. ( 28636758 )
2017
39
From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. ( 28677122 )
2017
40
An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. ( 28697444 )
2017
41
Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life. ( 28759122 )
2017
42
Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition. ( 28794439 )
2017
43
Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. ( 28925540 )
2017
44
Effects of early overnutrition on the renal response to Ang II and expression of RAAS components in rat renal tissue. ( 28958692 )
2017
45
Developmental programming of the pancreatic islet by in utero overnutrition. ( 29657386 )
2017
46
Postnatal prebiotic fibre intake mitigates some detrimental metabolic outcomes of early overnutrition in rats. ( 26407845 )
2016
47
FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. ( 26420862 )
2016
48
Postnatal overnutrition in mice leads to impaired pulmonary mechanics in response to salbutamol. ( 26497334 )
2016
49
Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice. ( 26608021 )
2016
50
Food Insecurity Is Associated with Undernutrition but Not Overnutrition in Ecuadorian Women from Low-Income Urban Neighborhoods. ( 27110253 )
2016
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Variations for Overnutrition

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Expression for Overnutrition

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Search GEO for disease gene expression data for Overnutrition.
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Pathways for Overnutrition

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Pathways related to Overnutrition according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 67
Show member pathways
 13.41 ADIPOQ GCG IL6 INS LEP LEPR
2
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 66
Show member pathways
 12.65 ADIPOQ IL6 INS LEP RETN SOCS3
3
Prolactin Signaling Pathway 1 38
Show member pathways
 12.34 INS LEP LEPR SOCS3
4
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.3 ADIPOQ INS LEP LEPR PPARG SREBF1
5
Glucose / Energy Metabolism 4
12.29 ADIPOQ FTO GCG INS PPARG SREBF1
6
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.26 IL6 LEP LEPR SOCS3
7
Peptide hormone metabolism 67
Show member pathways
 12.11 GCG GHRL INS LEP
9
Insulin resistance 38
Show member pathways
 11.85 IL6 INS SOCS3 SREBF1
10
Type II diabetes mellitus 1 38
Show member pathways
 11.74 ADIPOQ INS SOCS3
11
PPAR signaling pathway 38
11.62 ADIPOQ PPARG UCP1
12
Sterol Regulatory Element-Binding Proteins (SREBP) signalling 1
11.61 INS PPARG SREBF1
13
ATF-2 transcription factor network 1
11.45 IL6 INS SOCS3
14
Signaling events mediated by PTP1B 1
11.43 INS LEP LEPR SOCS3
15
Adipogenesis 1
11.4 ADIPOQ IL6 INS LEP PPARG RETN
16
Differentiation Pathway 1
11.38 FGF1 IL6 INS
17
Adipocytokine signaling pathway 38
11.27 ADIPOQ AGRP LEP LEPR NPY SOCS3
18
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 11.15 CRP LEP LEPR SOCS3
19
Differentiation of white and brown adipocyte 1
11.05 ADIPOQ LEP PPARG
20
Transcription factor regulation in adipogenesis 1
10.97 ADIPOQ IL6 LEP PPARG
21
Syndecan-3-mediated signaling events 1
10.84 AGRP MC4R
22
FTO Obesity Variant Mechanism 1
10.46 FTO UCP1
Sources

GO Terms for Overnutrition

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Cellular components related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ADIPOQ AGRP CRP FGF1 GCG GHRL
2 endoplasmic reticulum lumen GO:0005788 9.46 GCG GHRL IL6 INS
3 extracellular space GO:0005615 9.4 ADIPOQ AGRP CRP FGF1 GCG GHRL

Biological processes related to Overnutrition according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.86 ADIPOQ GHRL SOCS3
2 neuropeptide signaling pathway GO:0007218 9.86 AGRP NPY PYY
3 cellular response to insulin stimulus GO:0032869 9.85 ADIPOQ PPARG SREBF1
4 circadian rhythm GO:0007623 9.85 ADIPOQ AGRP LEP SREBF1
5 cholesterol metabolic process GO:0008203 9.84 LEP LEPR SREBF1
6 response to nutrient GO:0007584 9.84 ADIPOQ LEP PPARG
7 response to insulin GO:0032868 9.84 AGRP LEP MC4R RETN
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 IL6 LEP SOCS3
9 regulation of insulin secretion GO:0050796 9.81 GCG LEP SREBF1
10 regulation of blood pressure GO:0008217 9.8 LEP NPY PPARG
11 glucose metabolic process GO:0006006 9.8 ADIPOQ GHRL INS LEP
12 hormone-mediated signaling pathway GO:0009755 9.77 AGRP GHRL PPARG
13 glucose homeostasis GO:0042593 9.77 ADIPOQ INS LEP LEPR PPARG
14 response to nutrient levels GO:0031667 9.76 ADIPOQ GHRL LEP UCP1
15 acute-phase response GO:0006953 9.74 CRP IL6 INS
16 negative regulation of collagen biosynthetic process GO:0032966 9.7 IL6 PPARG
17 positive regulation of cellular protein metabolic process GO:0032270 9.7 ADIPOQ INS
18 energy reserve metabolic process GO:0006112 9.7 LEP LEPR MC4R
19 positive regulation of insulin receptor signaling pathway GO:0046628 9.69 INS LEP
20 regulation of fat cell differentiation GO:0045598 9.69 LEP PPARG
21 fatty acid oxidation GO:0019395 9.69 ADIPOQ PPARG
22 negative regulation of gluconeogenesis GO:0045721 9.69 ADIPOQ INS LEPR
23 interleukin-6-mediated signaling pathway GO:0070102 9.68 IL6 SOCS3
24 central nervous system neuron development GO:0021954 9.67 LEP NPY
25 sexual reproduction GO:0019953 9.66 LEP LEPR
26 negative regulation of blood vessel diameter GO:0097756 9.65 CRP INS
27 leptin-mediated signaling pathway GO:0033210 9.65 LEP LEPR
28 positive regulation of cholesterol biosynthetic process GO:0045542 9.65 FGF1 SREBF1
29 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.65 ADIPOQ CRP PPARG
30 positive regulation of cold-induced thermogenesis GO:0120162 9.65 ADIPOQ GHRL LEP LEPR UCP1
31 diet induced thermogenesis GO:0002024 9.63 MC4R UCP1
32 negative regulation of acute inflammatory response GO:0002674 9.62 INS PPARG
33 positive regulation of feeding behavior GO:2000253 9.61 AGRP GHRL
34 regulation of bone remodeling GO:0046850 9.61 LEP LEPR
35 regulation of feeding behavior GO:0060259 9.61 AGRP LEPR MC4R
36 regulation of brown fat cell differentiation GO:0090335 9.59 FTO LEP
37 regulation of metabolic process GO:0019222 9.58 LEP MC4R
38 positive regulation of appetite GO:0032100 9.58 GHRL NPY
39 negative regulation of lipid storage GO:0010888 9.58 CRP IL6 LEP
40 bone growth GO:0098868 9.56 LEP LEPR
41 negative regulation of feeding behavior GO:2000252 9.5 INS MC4R RETN
42 adult feeding behavior GO:0008343 9.46 AGRP GHRL LEP NPY
43 regulation of signaling receptor activity GO:0010469 9.36 ADIPOQ AGRP FGF1 GCG GHRL IL6
44 feeding behavior GO:0007631 9.35 AGRP GCG MC4R NPY PYY
45 G protein-coupled receptor signaling pathway GO:0007186 10.18 GCG GHRL INS MC4R NPY PPARG
46 negative regulation of apoptotic process GO:0043066 10.08 GCG GHRL IL6 LEP SOCS3

Molecular functions related to Overnutrition according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.43 GHRL NPY PYY
2 signaling receptor binding GO:0005102 9.43 ADIPOQ AGRP CRAT GCG LEP NPY
3 neuropeptide hormone activity GO:0005184 9.33 AGRP NPY PYY
4 hormone activity GO:0005179 9.23 ADIPOQ GCG GHRL INS LEP NPY
Sources

Sources for Overnutrition

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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