Pain Agnosia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PNG002 MIFTS: 50	Pain Agnosia Categories: Mental diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia ¹¹ ¹⁴ ¹⁶

Analgesia ¹¹ ¹⁴

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060145

EFO ¹⁶ EFO_1001484

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Summaries for Pain Agnosia

Disease Ontology: ¹¹ An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary: Pain Agnosia, also known as analgesia, is related to episodic pain syndrome, familial, 1 and chronic pain. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Benzoic acid and Mineral oil have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and liver, and related phenotypes are nervous system and normal

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Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1174)

#	Related Disease	Score	Top Affiliating Genes
1	episodic pain syndrome, familial, 1	32.1	TRPV1 TRPA1 SCN9A
2	chronic pain	32.0	SCN9A OPRM1
3	ileus	31.6	OPRM1 IL6 CALCA
4	inguinal hernia	31.5	TCF21 POMC IL6
5	amnestic disorder	31.4	PDYN OXT OPRM1 FOS
6	postpartum depression	31.3	POMC PNOC OXT IL6
7	paine syndrome	31.0	TRPV1 TRPA1 TAC1 SCN9A POMC PNOC
8	opiate dependence	31.0	POMC PNOC PDYN OPRM1 OPRL1 OPRK1
9	withdrawal disorder	31.0	POMC PNOC PDYN OPRM1 OPRK1 NPFF
10	radiculopathy	30.9	TAC1 IL6 CALCA
11	fibromyalgia	30.9	SCN9A POMC PNOC OXT OPRM1 IL6
12	trigeminal neuralgia	30.8	TRPV1 TRPA1 TAC1 SCN9A CALCA
13	paralytic ileus	30.8	TCF21 TAC1 IL6 CALCA
14	complex regional pain syndrome	30.8	TRPV1 TRPA1 TAC1 SCN9A OPRM1 IL6
15	post-traumatic stress disorder	30.8	POMC OXT IL6 FOS FAAH
16	alcohol use disorder	30.8	POMC PDYN OPRM1 IL6
17	leptin deficiency or dysfunction	30.7	POMC OXT IL6 CCK
18	diabetic neuropathy	30.7	TRPV1 TRPA1 TAC1 SCN9A CALCA
19	reflex sympathetic dystrophy	30.7	TRPV1 TAC1 SCN9A CALCA
20	major depressive disorder	30.7	TAC1 POMC PDYN OXT OPRM1 IL6
21	arachnoiditis	30.6	TAC1 POMC
22	irritable bowel syndrome	30.6	TRPV1 TRPA1 TAC1 POMC IL6 FOS
23	motion sickness	30.6	TAC1 POMC OPRM1 FOS
24	morphine dependence	30.6	PDYN OXT OPRM1 OPRK1 FOS CCK
25	mononeuropathy	30.6	TRPV1 TAC1 IL6 CALCA
26	cystitis	30.5	TRPV1 TAC1 IL6
27	persistent fetal circulation syndrome	30.5	POMC OXT IL6
28	duodenal ulcer	30.5	IL6 CCK CALCA
29	acute stress disorder	30.5	POMC OXT
30	bowel dysfunction	30.4	TRPV1 TAC1 SAG POMC OPRM1 OPRK1
31	opioid abuse	30.4	TAC1 SAG POMC PNOC PDYN OPRM1
32	peripheral nervous system disease	30.4	TRPV1 TRPA1 TAC1 SCN9A POMC OPRM1
33	mood disorder	30.4	POMC PDYN OXT IL6
34	alcohol dependence	30.4	POMC PNOC PDYN OPRM1 OPRL1 OPRK1
35	substance abuse	30.4	POMC PDYN OXT OPRM1 OPRK1 IL6
36	panic disorder	30.4	TAC1 POMC IL6 CCK
37	anxiety	30.4	TRPV1 TAC1 POMC PNOC PDYN OXT
38	diabetes insipidus	30.3	SAG POMC OXT CALCA
39	diarrhea	30.3	TRPV1 TAC1 IL6 CCK CALCA
40	drug dependence	30.3	POMC PNOC PDYN OPRM1 OPRL1 OPRK1
41	bell's palsy	30.3	LIPN IL6
42	neurogenic bladder	30.2	TRPV1 TAC1 CALCA
43	frozen shoulder	30.2	TAC1 IL6 CALCA
44	epilepsy	30.2	SCN9A POMC PDYN OPRM1 IL6 CCK
45	spondylosis	30.2	TAC1 LIPN IL6
46	erythromelalgia	30.2	TRPV1 TRPA1 TAC1 SCN9A
47	aspiration pneumonitis	30.2	OXT IL6
48	mediastinitis	30.2	TCF21 IL6
49	psychotic disorder	30.2	PDYN OXT OPRM1 IL6 FOS CCK
50	bronchitis	30.2	TAC1 IL6 CALCA

Graphical network of the top 20 diseases related to Pain Agnosia:

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Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.24	CALCA CCK FAAH FOS IL6 OPRK1
2	normal	MP:0002873	10.06	CALCA FAAH FOS OPRL1 OPRM1 SCN9A
3	homeostasis/metabolism	MP:0005376	10.06	CALCA CCK FAAH FOS IL6 LIPN
4	renal/urinary system	MP:0005367	9.97	CALCA CCK IL6 OXT POMC SCN9A
5	adipose tissue	MP:0005375	9.91	FOS IL6 OPRM1 OXT PDYN POMC
6	behavior/neurological	MP:0005386	9.86	CALCA FAAH FOS IL6 NPFF OPRK1
7	integument	MP:0010771	9.53	CALCA FAAH FOS IL6 OPRK1 OPRL1

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Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 355)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Benzoic acid

Approved, Investigational

Phase 4

65-85-0

243

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Ethyl chloride

Approved, Experimental, Investigational

Phase 4

75-00-3

6337

Metamizole

Approved, Investigational, Withdrawn

Phase 4

50567-35-6

3111 522325

Remifentanil

Approved

Phase 4

132875-61-7

60815

Dimenhydrinate

Approved

Phase 4

523-87-5

10660

Orphenadrine

Approved

Phase 4

83-98-7

4601

Ondansetron

Approved, Withdrawn

Phase 4

99614-02-5

4595

Racephedrine

Approved, Experimental

Phase 4

299-42-3, 90-82-4, 90-81-3

5032 9294 7028

Glycopyrronium

Approved, Investigational, Vet_approved

Phase 4

596-51-0, 740028-90-4

3494

Flurbiprofen

Approved, Investigational

Phase 4

5104-49-4

3394

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Nalbuphine

Approved

Phase 4

20594-83-6

5311304

Meperidine

Approved

Phase 4

57-42-1

4058

Esmolol

Approved, Withdrawn

Phase 4

103598-03-4, 81147-92-4

59768

Prilocaine

Approved

Phase 4

721-50-6

4906

Salmon calcitonin

Approved, Investigational

Phase 4

47931-85-1

155817456

Hydrocodone

Approved, Illicit, Investigational

Phase 4

125-29-1

5284569

Parecoxib

Approved

Phase 4

198470-84-7

119828

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Nitroglycerin

Approved, Investigational

Phase 4

55-63-0

4510

Pentazocine

Approved, Vet_approved

Phase 4

359-83-1

4736 441278

Palonosetron

Approved, Investigational

Phase 4

119904-90-4, 135729-56-5

148211 6337614

Dronabinol

Approved, Illicit

Phase 4

1972-08-3

16078

Nitric Oxide

Approved

Phase 4

10102-43-9

145068

Vecuronium

Approved, Investigational

Phase 4

50700-72-6, 86029-43-8

39765 39764

Famotidine

Approved

Phase 4

76824-35-6

3325 5702160

Esomeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6, 119141-88-7

9568614 4594

Methoxyflurane

Approved, Investigational, Vet_approved, Withdrawn

Phase 4

76-38-0

4116

Desflurane

Approved

Phase 4

57041-67-5

42113

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Rocuronium

Approved

Phase 4

119302-91-9, 143558-00-3

441290

Oxytocin

Approved, Vet_approved

Phase 4

50-56-6

439302 53477758

Acetylsalicylic acid

Approved, Vet_approved

Phase 4

50-78-2

2244

Methocarbamol

Approved, Vet_approved

Phase 4

532-03-6

4107

Granisetron

Approved, Investigational

Phase 4

109889-09-0

3510 5284566

Scopolamine

Approved, Investigational

Phase 4

51-34-3

153311 3000322

Aripiprazole

Approved, Investigational

Phase 4

129722-12-9

60795

Cyclobenzaprine

Approved

Phase 4

303-53-7

2895

Isoflurane

Approved, Vet_approved

Phase 4

26675-46-7

3763

Pancrelipase

Approved, Investigational

Phase 4

53608-75-6

8519

Cisatracurium

Approved, Investigational

Phase 4

96946-41-7

62887

Atracurium

Approved, Experimental, Investigational

Phase 4

64228-79-1

47319

Butorphanol

Approved, Illicit, Vet_approved

Phase 4

58786-99-5, 42408-82-2

5361092

Dezocine

Approved, Investigational

Phase 4

53648-55-8

3033053

Interventional clinical trials:

(show top 50) (show all 2501)

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children	Unknown status	NCT02773602	Phase 4	Dexamethasone;Clonidine;Normal Saline
2	Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy	Unknown status	NCT02523846	Phase 4	morphine
3	Opioid-sparing Effect of Intravenous Ibuprofen	Unknown status	NCT03016650	Phase 4	Acetaminophen;Ibuprofen
4	Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults	Unknown status	NCT03901612	Phase 4	Ropivacaine 0.2%;saline 09%
5	Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation: a Prospective, Randomized, Multicenter Clinical Study	Unknown status	NCT04315935	Phase 4	Butorphanol and Propofol;Fentanyl and Propofol
6	Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery	Unknown status	NCT03014713	Phase 4	Dezocine;Flubiprofen;Dexmedetomidine
7	Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial.	Unknown status	NCT00532662	Phase 4	S(+)-ketamine
8	Analgesia After Total Knee Arthroplasty: Randomized Controlled Trial Comparing (a) Periarticular Multimodal Technique With (B) Continuous Femoral Nerve Block + Posterior Capsular Injection	Unknown status	NCT00869037	Phase 4	Periarticular Injection;CFNB + Posterior Capsular Injection
9	Ketamine and Postoperative Analgesia in Children	Unknown status	NCT00200564	Phase 4	ketamine
10	The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery	Unknown status	NCT02503826	Phase 4	Sufentanil;Midazolam;propofol;cisatracurium
11	Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine	Unknown status	NCT01158586	Phase 4	Levobupivacaine
12	Efficacy of Lidocaine as Local Anesthetics in Children Under Procedural Sedation and Analgesia Using Ketamine	Unknown status	NCT02205502	Phase 4	Lidocaine;Normal saline
13	The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy	Unknown status	NCT03831321	Phase 4	Diclofenac Sodium;Lubricant Gel
14	Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair	Unknown status	NCT02292095	Phase 4
15	Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study.	Unknown status	NCT02279628	Phase 4	Ropivacaine;Morphine
16	A Randomized Controlled Trial to Compare the Efficacy and Safety of NALDEBAIN With Intravenous Patient-Controlled Analgesia With Fentanyl for the Treatment of Post-Laparotomy Surgery	Unknown status	NCT03296488	Phase 4	Nalbuphine Sebacate;Fentanyl Citrate
17	Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy	Unknown status	NCT03288428	Phase 4	Nalbuphine;Morphine
18	Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia After Spontaneous Vaginal Birth in Obese Women: A Randomised Controlled Trial	Unknown status	NCT03694873	Phase 4	Tramadol Hydrochloride;Celecoxib 200mg
19	Intravenous Lidocaine for Perioperative and Postoperative Analgesia	Unknown status	NCT03921567	Phase 4	Lidocaine Hydrochloride;Lidocaine Hydrochloride and Ketamine;Placebo
20	Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study	Unknown status	NCT02733835	Phase 4	Remifentanil
21	Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty	Unknown status	NCT00864409	Phase 4	ropivacaine 0,2%;saline.9%
22	Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial.	Unknown status	NCT03018171	Phase 4	Clonidine;Sufentanil
23	Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study	Unknown status	NCT00480142	Phase 4	Oxycodone 10 mg
24	Opioid-Sparing Protocol Using for Postoperative Pain Management Comparing With Opioid-based Patient Control Analgesia After Simultaneous Bilateral Total Knee Arthroplasty: a Randomized Controlled Trial	Unknown status	NCT04314505	Phase 4	Opioid-Sparing Protocol;Opioid-Based Patient Controlled Analgesia
25	A Placebo-controlled, Double-blinded, Randomized Pilot Study of Bupivacaine Liposome Injectable Suspension (EXPAREL) for Minimally Invasive Supracervical Hysterectomies Postsurgical Analgesia	Unknown status	NCT03769714	Phase 4	Saline Solution for Injection;Exparel
26	Oral Phenazopyridine Versus Intravesical Lidocaine for Office OnabotulinumtoxinA Analgesia: A Randomized Controlled Trial	Unknown status	NCT03755089	Phase 4	Phenazopyridine;Lidocaine 2% Injectable Solution
27	the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation	Unknown status	NCT02635802	Phase 4	Remifentanil;Lidocaine;Remifentanil+Lidocaine;Midazolam
28	Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial	Unknown status	NCT02094339	Phase 4	ropivacaine;opioid
29	Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial	Unknown status	NCT02300480	Phase 4
30	The Effect of Intrathecal Versus Intravenous Dexmeditomedine on Postoperative Analgesia in Transurethral Resection of the Prostate	Unknown status	NCT04618965	Phase 4	control group;Intrathecal dexmedetomidine;Intravenous dexmedetomidine
31	Comparison of the Postoperative Analgesia Effectiveness of Preemptive Intravenous Ibuprofen and Paracetamol in Patients Undergoing Laparoscopic Cholecystectomy	Unknown status	NCT03063658	Phase 4	Paracetamol;Ibuprofen 800 mg
32	Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial	Unknown status	NCT02284620	Phase 4
33	Comparing the Delivery of Local Anesthetic by Programmed Intermittent Bolus Versus Continuous Infusion Through a Popliteal Sciatic Nerve Catheter for Analgesia Following Major Ankle Surgery	Unknown status	NCT02707874	Phase 4	CI 0.2% ropivacaine;PIB 0.2% ropivacaine
34	Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery - a Randomized, Blinded, Placebo Controlled Study	Unknown status	NCT02576223	Phase 4	Ropivacaine hydrochloride;Isotonic Saline
35	Comparison of the ED95 Dose of 0.075% and 0.1% Bupivacaine for Labour Analgesia in Primigravida.	Unknown status	NCT02116842	Phase 4	0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
36	The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients	Unknown status	NCT02078583	Phase 4	Fentanyl;Remifentanil;Normal saline
37	Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery: A Randomized Single Blinded Control Trial	Unknown status	NCT02672813	Phase 4
38	Correlation Between Acute Analgesia and Long-Term Function Following Ankle	Unknown status	NCT02667730	Phase 4	Acetaminophen;Naproxen;Celecoxib
39	Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study	Unknown status	NCT02552459	Phase 4	Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
40	Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial	Unknown status	NCT02114463	Phase 4	ropivacaine;flurbiprofen
41	Randomised Controlled Trial Comparing the Effect of Intravenous Dexamethasone vs. Placebo on the Duration of Analgesia of Spinal Anaesthesia for Caesarean Sections at the Victoria Jubilee Hospital in Jamaica	Unknown status	NCT04624360	Phase 4	Dexamethasone
42	Effects of Intranasal Injection of Dexmedetomidine Plus Bupivacaine on Anesthesia & Analgesia in Septoplasty Surgeries	Unknown status	NCT03926663	Phase 4	Dexmedetomidine;Bupivacaine
43	Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial	Unknown status	NCT02691403	Phase 4	levo-bupivacaine;normal saline
44	Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection	Unknown status	NCT00822133	Phase 4	lidocaine;ketamine;non-active drug cream
45	Post-operative Analgesia Efficacy Using Ultrasound-guided Transmuscular Quadratus Lumborum Block Versus Ultrasound-guided Quadratus Lumborum Type II Block.	Unknown status	NCT03100994	Phase 4	Bupivacaine
46	The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia：A Randomized, Double Blind Controlled Trial	Unknown status	NCT02535273	Phase 4	Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
47	Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy: a Prospective, Randomized, Double-blind Study.	Unknown status	NCT03394001	Phase 4	Lidocaine Hydrochloride;Ketorolac tromethamine
48	A Pilot Study for a Prospective, Randomized Controlled Trial of Techniques for Perioperative Analgesia for Live Liver Donors	Unknown status	NCT03393988	Phase 4	Fentanyl infusion;Dexmedetomidine
49	Effect of Preoperative Administration of Oral Pregabalin on the Postoperative Analgesia in Patients Scheduled for Radiofrequency Ablationof Focal Lesions in the Liver	Unknown status	NCT03151213	Phase 4	Pregabalin 150mg
50	The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic	Unknown status	NCT04043624	Phase 4	Lidocaine;Saline

Search NIH Clinical Center for Pain Agnosia

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Genetic Tests for Pain Agnosia

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Anatomical Context for Pain Agnosia

Organs/tissues related to Pain Agnosia:

MalaCards : Breast, Brain, Liver, Skin, Colon, Lung, Heart

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Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30003)

#	Title	Authors	PMID	Year
1	Evaluating the role for regional analgesia in children with spina bifida: a retrospective observational study comparing the efficacy of regional versus systemic analgesia protocols following major urological surgery. ⁶²	Moore RP...PURSUE Study Group	36167478	2023
2	Blockade of the orexin receptors in the ventral tegmental area could attenuate the stress-induced analgesia: A behavioral and molecular study. ⁶²	Askari K...Haghparast A	36116673	2023
3	A novel anti-NGF PEGylated Fab' provides analgesia with lower risk of adverse effects. ⁶²	Koya Y...Kamohara M	36458900	2023
4	Hystricomorph Rodent Analgesia. ⁶²	Sadar MJ...Mans C	36402480	2023
5	PENG block: a possible ally of the multimodal analgesia. ⁶²	Carella M...Lecoq JP	36261262	2023
6	Ultrasound-guided selective peripheral nerve block compared with the sub-dissociative dose of ketamine for analgesia in patients with extremity injuries. ⁶²	Mohanty CR...Behera SHP	36332503	2023
7	Association of anesthesia and analgesia with long-term mortality after hip fracture surgery: an analysis of the Australian and New Zealand hip fracture registry. ⁶²	Lin DY...Jaarsma R	36137734	2023
8	Dexamethasone Does Not Provide Additional Clinical Analgesia Effect to Local Wound Infiltration: A Comprehensive Systematic Review and Meta-Analysis. ⁶²	Ye X...Wang YT	35081741	2023
9	Comparison of Ketamine, Dexmedetomidine and Lidocaine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial. ⁶²	Ustun YB...Kaya C	35382963	2022
10	Efficacy of Electroacupuncture Combined with Intravenous Patient-controlled Analgesia after Cesarean Section: A Randomized Clinical Trial. ⁶²	Jin Y...Wang L	36464237	2022
11	Efficacy of postoperative analgesia with duloxetine in posthemorrhoidectomy pain: a prospective, randomized, double-blind and placebo-controlled trial. ⁶²	Gerber MT...de Oliveira Filho GR	36457090	2022
12	Pain analgesia or desensitization? A longitudinal lab-based study on the link between pain and nonsuicidal self-injury. ⁶²	Boyne H...Hamza CA	36384068	2022
13	Effects of Systemic Lidocaine Versus Dexmedetomidine on the Recovery Quality and Analgesia After Thyroid Cancer Surgery: A Randomized Controlled Trial. ⁶²	Shu T...Ma L	36203077	2022
14	Implementation of a perioperative pain management algorithm reduces the use of opioid analgesia following pelvic exenteration surgery. ⁶²	Johnstone CS...McLachlan AJ	36461690	2022
15	CYP2D in the brain impacts oral hydrocodone analgesia in vivo. ⁶²	Richards J...Tyndale RF	36241086	2022
16	Comparison of Femoral Nerve Catheter, Adductor Canal Catheter, and Periarticular Liposomal Bupivacaine Infiltration for Postoperative Analgesia after Primary Total Knee Arthroplasty. ⁶²	Dobson SW...Henshaw DS	36470364	2022
17	Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: a Retrospective Analysis. ⁶²	Parhar D...Liu DM	36473614	2022
18	Differential Effects of Cannabidiol and a Novel Cannabidiol Analog on Oxycodone Place Preference and Analgesia in Mice: an Opioid Abuse Deterrent with Analgesic Properties. ⁶²	Harris HM...Sufka KJ	34962133	2022
19	Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis. ⁶²	Xuan C...Wang J	36404458	2022
20	How painful are cats after neutering - a field study using multimodal analgesia with intraperitoneal ropivacaine in a -neuter-return program in feral cats. ⁶²	Heitzmann V...Steblaj B	36454013	2022
21	Does local infiltration analgesia in total joint arthroplasty offer any protection from prosthetic joint infections? An invitro experimental study. ⁶²	Tandra V...Khan O	36453651	2022
22	Wearable, Noninvasive, Pulsed Shortwave (Radiofrequency) Therapy for Analgesia and Opioid Sparing following Outpatient Surgery: A Proof-of-Concept Case Series. ⁶²	Ilfeld BM...Finneran JJ	36463434	2022
23	A retrospective review of post-intubation sedation and analgesia practices in a South African private ambulance service. ⁶²	de Kock JM...Stassen W	36415448	2022
24	Hot Off the Press! Commentary on "Maternal Fever Associated With Continuous Spinal Versus Epidural Labor Analgesia: A Single-Center Retrospective Study". ⁶²	Baron EL...Katz D	36384011	2022
25	Analgesia as part of the orotracheal intubation induction sequence. ⁶²	Tejado S...Alcantara S	36194259	2022
26	Local infiltration of HYR-PB21, a sustained-release formulation of bupivacaine, provides analgesia and reduces opioid requirement after haemorrhoidectomy: a randomised controlled trial. ⁶²	Cui J...Zhang S	36243580	2022
27	Inter-semispinal plane (ISP) block for postoperative analgesia following cervical spine surgery: A prospective randomized controlled trial. ⁶²	Mostafa SF...Belal AM	36228453	2022
28	Opioid-free analgesia: is it achievable in open colorectal surgery without neuraxial block? ⁶²	Lohsiriwat V	36193955	2022
29	Periarticular multimodal analgesia in decreasing perioperative pain in tibial plateau fractures: A double blind randomized controlled pilot study. ⁶²	Kellam PJ...Haller JM	36207154	2022
30	Prolonged duration of epidural labour analgesia decreases the success rate of epidural anaesthesia for caesarean section. ⁶²	Jian Z...Yan G	35443838	2022
31	A standardized post-cesarean analgesia regimen reduces postpartum opioid use. ⁶²	Meyer MF...Antony KM	34445918	2022
32	Ultrasound-guided quadratus lumborum block provided more effective analgesia for children undergoing lower abdominal laparoscopic surgery: a randomized clinical trial. ⁶²	Zhang Y...Yang JJ	35764836	2022
33	ASO Author Reflections: Non-Steroidal Anti-Inflammatory Drugs are Safe in the Post-Discharge Setting After Lumpectomy and Sentinel Lymph Node Biopsy with Multimodal Analgesia. ⁶²	Pawloski KR...Moo TA	34387771	2022
34	Methylene Blue Combined with Ropivacaine for Intercostal Nerve Block After Autologous Costal Cartilage Removal in Juvenile Patients. ⁶²	Liu Y...Chen Z	36109354	2022
35	Future liver remnant volume is associated with postoperative fentanyl consumption following open donor hepatectomy: a retrospective multivariate analysis. ⁶²	Tsukano Y...Yamamoto T	36190573	2022
36	Efficacy of ultrasound-guided single-injection erector spinae plane block for thoracoscopic wedge resection: a prospective randomized control trial. ⁶²	Klaibert B...Wilson J	36150741	2022
37	Association of pain, analgesic, psychological, and socioeconomic factors with sub-acute pain after childbirth: A prospective cohort study. ⁶²	Tan CW...Sng BL	36208586	2022
38	Methadone rotation for cancer pain: an observational study. ⁶²	Tan C...Hum A	32321728	2022
39	An Enhanced Recovery After Surgery protocol for robotic-assisted laparoscopic nephrectomies utilizing a quadratus lumborum block. ⁶²	Yip W...Kim MP	35142979	2022
40	Feasibility and efficacy of erector spinae plane block versus transversus abdominis plane block in laparoscopic bariatric surgery: a randomized comparative trial. ⁶²	Elshazly M...Mohamed TMK	35581710	2022
41	Plasmatic catecholamines after neuraxial labour analgesia: A randomised controlled trial comparing epidural versus combined spinal-epidural. ⁶²	Andrade Santos S...Edson Vieira J	36067925	2022
42	Prevention and treatment of pediatric pain and anxiety caused by botulinum neurotoxin A injections: Inadmissible without nitrous oxide analgesia and sedation? ⁶²	Friedrichsdorf SJ	36089662	2022
43	Changes in sensory block level during a programmed intermittent epidural bolus regimen for labour analgesia: a prospective observational cohort study. ⁶²	Casellato JF...Carvalho JCA	36076123	2022
44	Comparison Between Periarticular Analgesia Versus Intraarticular Injection for Effectiveness and Safety After Total Knee Arthroplasty. ⁶²	Su C...Chen L	36123240	2022
45	A Randomized Controlled Pilot Study Using Ultrasound-Guided Percutaneous Cryoneurolysis of the Infrapatellar Branch of the Saphenous Nerve for Analgesia Following Total Knee Arthroplasty. ⁶²	Swisher MW...Ilfeld BM	36018541	2022
46	Effect of analgesia with pethidine during labour on false positivity of newborn hearing screening test. ⁶²	Kadirogullari P...Seckin KD	33882796	2022
47	Advantages of Transmuscular Quadratus Lumborum Block via Subfascial Approach Versus Extrafascial Approach for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Randomized Controlled Study. ⁶²	He WQ...Yi B	36221155	2022
48	Antagonism of the orexin receptors in the ventral tegmental area diminished the stress-induced analgesia in persistent inflammatory pain. ⁶²	Shakerinava P...Haghparast A	36155089	2022
49	Ultrasound-Guided Anterior Quadratus Lumborum Block at Lateral Supra-Arcuate Ligament vs Thoracic Epidural Analgesia after Open Liver Surgery: A Randomized, Controlled, Noninferiority Trial. ⁶²	Gu B...Jiang H	36102582	2022
50	Paravertebral block versus erector spinae plane block for analgesia in modified radical mastectomy: a randomized, prospective, double-blind study. ⁶²	Sivrikoz N...Sungur Z	36282220	2022

Sources

Genes for Pain Agnosia

Genes related to Pain Agnosia (0 elite genes):

(show top 50) (show all 51)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OPRM1	Opioid Receptor Mu 1	Protein Coding	9.5	DISEASES inferred ¹⁴
2	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	8.9	DISEASES inferred ¹⁴
3	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	8.8	DISEASES inferred ¹⁴
4	TAC1	Tachykinin Precursor 1	Protein Coding	8.68	DISEASES inferred ¹⁴
5	PDYN	Prodynorphin	Protein Coding	8.67	DISEASES inferred ¹⁴
6	POMC	Proopiomelanocortin	Protein Coding	8.32	DISEASES inferred ¹⁴
7	PNOC	Prepronociceptin	Protein Coding	8.32	DISEASES inferred ¹⁴
8	TCF21	Transcription Factor 21	Protein Coding	8.23	DISEASES inferred ¹⁴
9	OPRK1	Opioid Receptor Kappa 1	Protein Coding	8.09	DISEASES inferred ¹⁴
10	OPRL1	Opioid Related Nociceptin Receptor 1	Protein Coding	7.87	DISEASES inferred ¹⁴
11	TRPA1	Transient Receptor Potential Cation Channel Subfamily A Member 1	Protein Coding	7.78	DISEASES inferred ¹⁴
12	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	7.71	DISEASES inferred ¹⁴
13	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	7.71	DISEASES inferred ¹⁴
14	FAAH	Fatty Acid Amide Hydrolase	Protein Coding	7.64	DISEASES inferred ¹⁴
15	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	7.62	DISEASES inferred ¹⁴
16	LIPN	Lipase Family Member N	Protein Coding	7.62	DISEASES inferred ¹⁴
17	IL6	Interleukin 6	Protein Coding	7.6	DISEASES inferred ¹⁴
18	SAG	S-Antigen Visual Arrestin	Protein Coding	7.6	DISEASES inferred ¹⁴
19	NPFF	Neuropeptide FF-Amide Peptide Precursor	Protein Coding	7.58	DISEASES inferred ¹⁴
20	CCK	Cholecystokinin	Protein Coding	7.57	DISEASES inferred ¹⁴
21	ARRB2	Arrestin Beta 2	Protein Coding	7.56	DISEASES inferred ¹⁴
22	TRPM8	Transient Receptor Potential Cation Channel Subfamily M Member 8	Protein Coding	7.54	DISEASES inferred ¹⁴
23	IL1B	Interleukin 1 Beta	Protein Coding	7.54	DISEASES inferred ¹⁴
24	PENK	Proenkephalin	Protein Coding	7.54	DISEASES inferred ¹⁴
25	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	7.54	DISEASES inferred ¹⁴
26	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	7.51	DISEASES inferred ¹⁴
27	CNR1	Cannabinoid Receptor 1	Protein Coding	7.48	DISEASES inferred ¹⁴
28	NGF	Nerve Growth Factor	Protein Coding	7.45	DISEASES inferred ¹⁴
29	KNG1	Kininogen 1	Protein Coding	7.42	DISEASES inferred ¹⁴
30	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6	Protein Coding	7.42	DISEASES inferred ¹⁴
31	ALB	Albumin	Protein Coding	7.41	DISEASES inferred ¹⁴
32	TACR1	Tachykinin Receptor 1	Protein Coding	7.33	DISEASES inferred ¹⁴
33	TRIM13	Tripartite Motif Containing 13	Protein Coding	7.29	DISEASES inferred ¹⁴
34	TNF	Tumor Necrosis Factor	Protein Coding	7.27	DISEASES inferred ¹⁴
35	RIC8B	RIC8 Guanine Nucleotide Exchange Factor B	Protein Coding	7.26	DISEASES inferred ¹⁴
36	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	7.23	DISEASES inferred ¹⁴
37	NTS	Neurotensin	Protein Coding	7.16	DISEASES inferred ¹⁴
38	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	7.16	DISEASES inferred ¹⁴
39	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	7.13	DISEASES inferred ¹⁴
40	P2RX3	Purinergic Receptor P2X 3	Protein Coding	7.11	DISEASES inferred ¹⁴
41	CRH	Corticotropin Releasing Hormone	Protein Coding	7.07	DISEASES inferred ¹⁴
42	OPRD1	Opioid Receptor Delta 1	Protein Coding	7.07	DISEASES inferred ¹⁴
43	CRP	C-Reactive Protein	Protein Coding	7.04	DISEASES inferred ¹⁴
44	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	7	DISEASES inferred ¹⁴
45	AIF1	Allograft Inflammatory Factor 1	Protein Coding	6.96	DISEASES inferred ¹⁴
46	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	6.96	DISEASES inferred ¹⁴
47	INS	Insulin	Protein Coding	6.93	DISEASES inferred ¹⁴
48	IL10	Interleukin 10	Protein Coding	6.93	DISEASES inferred ¹⁴
49	MGLL	Monoglyceride Lipase	Protein Coding	6.89	DISEASES inferred ¹⁴
50	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	6.86	DISEASES inferred ¹⁴

Sources

Variations for Pain Agnosia

Sources

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Sources

Pathways for Pain Agnosia

Pathways related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.18	TAC1 POMC PNOC PDYN OXT OPRM1
2	GPCR downstream signalling ⁶⁶ Show member pathways G alpha (i) signalling events ⁶⁶ G alpha (q) signalling events ⁶⁶ Signaling by GPCR ⁶⁶	13.17	CALCA CCK NPFF OPRK1 OPRL1 OPRM1
3	Class A/1 (Rhodopsin-like receptors) ⁶⁶ Show member pathways GPCR ligand binding ⁶⁶ GPCRs, class A rhodopsin-like ⁷⁴ Peptide GPCRs ⁷⁴ Peptide ligand-binding receptors ⁶⁶	12.49	TAC1 POMC PNOC PDYN OXT OPRM1
4	Neuroscience ³	12.33	SCN9A SAG POMC OPRM1 CALCA
5	Myometrial relaxation and contraction pathways ⁷⁴ Show member pathways Calcium regulation in cardiac cells ⁷⁴	12.26	OXT IL6 FOS CALCA
6	Spinal cord injury ⁷⁴	11.73	PDYN IL6 FOS
7	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.59	POMC OPRM1 IL6 FOS
8	Glucocorticoid receptor regulatory network ⁶¹	11.52	POMC IL6 FOS
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.26	IL6 FOS CALCA
10	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	10.96	TRPV1 POMC FOS
11	Chronic hyperglycemia impairment of neuron function ⁷⁴	9.85	TRPV1 TRPA1

Sources

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	dendrite	GO:0030425	10	TRPV1 PNOC PDYN OPRM1 OPRK1 NPFF
2	neuronal cell body	GO:0043025	9.9	CALCA OPRK1 PDYN PNOC TAC1 TRPV1
3	axon terminus	GO:0043679	9.56	PNOC PDYN OPRK1 NPFF
4	neuron projection	GO:0043005	9.36	TRPV1 SCN9A OPRM1 OPRL1 OPRK1 FOS

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.45	SAG POMC PNOC OXT OPRM1 OPRL1
2	inflammatory response	GO:0006954	10.31	CALCA FOS IL6 SCN9A TAC1 TRPV1
3	chemical synaptic transmission	GO:0007268	10.3	NPFF OPRK1 PDYN PNOC TAC1
4	positive regulation of cytosolic calcium ion concentration	GO:0007204	10.11	TRPV1 TAC1 OXT OPRM1 CALCA
5	response to activity	GO:0014823	10.1	OXT IL6 FOS
6	response to cold	GO:0009409	10.09	FOS SCN9A TRPA1
7	cellular response to nerve growth factor stimulus	GO:1990090	10.05	TRPV1 TAC1 CALCA
8	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GO:0007193	10.04	OPRM1 OPRL1 OPRK1
9	response to heat	GO:0009408	10.03	TRPV1 SCN9A CALCA
10	response to cocaine	GO:0042220	9.96	OXT OPRM1 OPRK1
11	eating behavior	GO:0042755	9.96	CCK OPRK1 OPRL1 OPRM1 OXT
12	negative regulation of blood pressure	GO:0045776	9.95	OXT OPRL1 CALCA
13	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0106072	9.92	OPRM1 OPRL1
14	estrous cycle	GO:0044849	9.91	OPRM1 OPRL1 OPRK1
15	regulation of sensory perception of pain	GO:0051930	9.91	OXT OPRM1 OPRL1 OPRK1
16	conditioned place preference	GO:1990708	9.89	OPRL1 OPRK1
17	thermoception	GO:0050955	9.88	TRPV1 TRPA1
18	detection of temperature stimulus involved in sensory perception of pain	GO:0050965	9.88	TRPV1 SCN9A CALCA
19	G protein-coupled opioid receptor signaling pathway	GO:0038003	9.88	OPRK1 OPRL1 OPRM1
20	response to pain	GO:0048265	9.87	TRPV1 TRPA1 TAC1 CALCA
21	sensory perception	GO:0007600	9.85	PNOC PDYN OPRM1 OPRL1 OPRK1
22	detection of chemical stimulus involved in sensory perception of pain	GO:0050968	9.84	TRPV1 TRPA1
23	adenylate cyclase-inhibiting opioid receptor signaling pathway	GO:0031635	9.83	OPRK1 OPRM1
24	positive regulation of gastric acid secretion	GO:0060454	9.81	OPRL1 TRPV1
25	sensory perception of pain	GO:0019233	9.77	OPRK1 OPRL1 OPRM1 SCN9A TAC1 TRPA1
26	behavior	GO:0007610	9.63	OPRL1 OPRK1
27	neuropeptide signaling pathway	GO:0007218	9.58	TAC1 POMC PNOC PDYN OPRM1 OPRL1
28	postsynaptic signal transduction	GO:0098926	9.49	OPRK1 OPRM1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.8	POMC OXT CCK CALCA
2	opioid receptor binding	GO:0031628	9.67	PNOC PDYN
3	neuropeptide binding	GO:0042923	9.63	OPRM1 OPRL1 OPRK1
4	opioid peptide activity	GO:0001515	9.62	PNOC PDYN
5	G protein-coupled opioid receptor activity	GO:0004985	9.26	OPRM1 OPRL1 OPRK1
6	neuropeptide hormone activity	GO:0005184	9.23	PNOC OXT NPFF CCK