MCID: PNG002
MIFTS: 51

Pain Agnosia

Categories: Mental diseases

Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 15 17
Analgesia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to chronic pain and ileus. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Dezocine and Pentazocine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 898)
# Related Disease Score Top Affiliating Genes
1 chronic pain 31.9 PNOC OPRM1
2 ileus 31.5 POMC OPRM1 CCK CALCA
3 amnestic disorder 31.4 PDYN OXT OPRM1 FOS
4 headache 31.4 TAC1 CCK CALCA
5 postpartum depression 31.2 POMC PNOC OXT
6 constipation 31.0 TRPV1 TAC1 PDYN OPRM1 OPRK1 FAAH
7 complex regional pain syndrome 30.9 TAC1 SCN9A POMC CALCA
8 fibromyalgia 30.9 SCN9A POMC PNOC OPRM1 CALCA
9 opioid addiction 30.8 PNOC OPRM1 OPRK1 CCK
10 irritable bowel syndrome 30.7 TRPV1 TRPA1 TAC1 POMC CCK
11 paralytic ileus 30.7 TCF21 TAC1
12 diabetic neuropathy 30.7 TRPV1 SCN9A CALCA
13 opiate dependence 30.7 POMC PENK PDYN OPRM1 OPRL1 OPRK1
14 reflex sympathetic dystrophy 30.7 TRPV1 TAC1 CALCA
15 withdrawal disorder 30.7 POMC PNOC PENK PDYN OPRM1 OPRK1
16 algoneurodystrophy 30.6 TAC1 CALCA
17 arachnoiditis 30.6 TAC1 POMC
18 motion sickness 30.6 TAC1 POMC OPRM1 FOS
19 bone cancer 30.6 TRPV1 PENK PDYN CALCA
20 substance abuse 30.5 POMC PDYN OPRM1
21 anxiety 30.5 TAC1 POMC PNOC PDYN OXT OPRM1
22 trigeminal neuralgia 30.5 TRPV1 TRPA1 TAC1 SCN9A LIPN FOS
23 morphine dependence 30.4 PENK PDYN OXT OPRM1 OPRK1 FOS
24 peripheral nervous system disease 30.3 TRPV1 TRPA1 TAC1 SCN9A POMC FOS
25 diarrhea 30.3 TAC1 POMC CCK CALCA
26 retrograde amnesia 30.3 POMC PDYN FOS
27 drug dependence 30.3 POMC PNOC PENK PDYN OPRM1 OPRL1
28 small cell cancer of the lung 30.3 POMC CCK CALCA
29 erythromelalgia 30.2 TRPV1 TRPA1 SCN9A
30 alcohol dependence 30.2 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
31 hypochondriasis 30.2 POMC OXT
32 opioid abuse 30.1 POMC PNOC PENK PDYN OPRM1 OPRL1
33 interstitial cystitis 30.0 TRPV1 TAC1 SCN9A
34 paroxysmal extreme pain disorder 30.0 TRPV1 TRPA1 SCN9A
35 migraine with or without aura 1 30.0 TRPV1 TRPA1 TAC1 SCN9A POMC PNOC
36 myofascial pain syndrome 30.0 TRPV1 TAC1 POMC CALCA
37 cluster headache 30.0 PNOC CALCA
38 sleep disorder 30.0 TAC1 POMC PDYN FOS
39 causalgia 30.0 TRPV1 TAC1 SCN9A CALCA
40 burning mouth syndrome 29.9 TRPV1 TAC1 SCN9A CALCA
41 neonatal abstinence syndrome 29.9 PNOC PDYN OPRM1 OPRL1 OPRK1
42 obsessive-compulsive disorder 29.9 POMC PDYN OXT CCK
43 attention deficit-hyperactivity disorder 29.8 OXT OPRM1 FOS FAAH ARRB2
44 paine syndrome 29.6 TRPV1 TRPA1 TAC1 SCN9A PNOC OPRM1
45 agnosia 29.0 TRPV1 TRPA1 TCF21 TAC1 SCN9A POMC
46 increased analgesia from kappa-opioid receptor agonist, female-specific 11.3
47 marsili syndrome 11.2
48 neuropathy, hereditary sensory and autonomic, type v 11.2
49 indifference to pain, congenital, autosomal recessive 11.1
50 restrictive dermopathy, lethal 11.0

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 ARRB2 CCK FAAH FOS NPFF OPRK1
2 homeostasis/metabolism MP:0005376 10.22 ARRB2 CCK FAAH FOS LIPN NPFF
3 integument MP:0010771 10.16 ARRB2 FAAH FOS OPRK1 OPRL1 OPRM1
4 adipose tissue MP:0005375 10.01 ARRB2 FOS OPRM1 OXT PDYN PENK
5 nervous system MP:0003631 9.97 ARRB2 CCK FAAH FOS OPRK1 OPRL1
6 no phenotypic analysis MP:0003012 9.5 CCK OPRM1 PDYN PENK POMC TRPA1
7 normal MP:0002873 9.28 FAAH FOS OPRL1 OPRM1 PENK SCN9A

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 413)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
2
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
3
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
4
Eprosartan Approved Phase 4 133040-01-4 5281037
5
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
6
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
7
Trandolapril Approved Phase 4 87679-37-6 5484727
8
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 130881 158781
9
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
10
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
11
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
12
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
13
Ramipril Approved Phase 4 87333-19-5 5362129
14
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
15
Zofenopril Approved Phase 4 81872-10-8
16
Enalaprilat Approved Phase 4 76420-72-9 6917719
17
Losartan Approved Phase 4 114798-26-4 3961
18
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
19
Fosinopril Approved Phase 4 98048-97-6 55891
20
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
21
Azilsartan medoxomil Approved, Investigational Phase 4 863031-21-4
22
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
23
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3
24
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
25
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
26
Meperidine Approved Phase 4 57-42-1 4058
27
Methadone Approved Phase 4 76-99-3 4095
28
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
29
Etomidate Approved Phase 4 33125-97-2 36339 667484
30
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
31
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
32
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
33
Prilocaine Approved Phase 4 721-50-6 4906
34
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
35
Orphenadrine Approved Phase 4 83-98-7 4601
36
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
37
Butorphanol Approved, Illicit, Vet_approved Phase 4 58786-99-5, 42408-82-2 5361092
38
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-56-5 148211
39
Nicotine Approved Phase 4 54-11-5 942 89594
40
Ephedrine Approved Phase 4 299-42-3 9294
41
Pseudoephedrine Approved Phase 4 90-82-4 7028
42
Povidone-iodine Approved Phase 4 25655-41-8
43
Dolasetron Approved, Investigational Phase 4 115956-12-2 60654
44
Promethazine Approved, Investigational Phase 4 60-87-7 4927
45
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
46
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
47
Famotidine Approved Phase 4 76824-35-6 3325
48
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
49
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
50
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510

Interventional clinical trials:

(show top 50) (show all 2523)
# Name Status NCT ID Phase Drugs
1 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
2 Effect of Bispectral Index (BIS) Monitoring on Faster Recovery Time and Analgesic Consumption in Abdominal Surgery Patients Unknown status NCT01470898 Phase 4
3 MethOxyflUraNe at moderaTe High AltItudes for PAIN Management: A Randomised, Double-blind, Cross-over Study Unknown status NCT03849027 Phase 4 Methoxyflurane;Placebo
4 the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation Unknown status NCT02635802 Phase 4 Remifentanil;Lidocaine;Remifentanil+Lidocaine;Midazolam
5 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
6 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
7 Oxycodone vs. Fentanyl in the Treatment of Early Postoperative Pain After Total Hip Replacement Unknown status NCT03019562 Phase 4 Oxycodone;Fentanyl
8 The Efficacy and the Safety of Dexmedetomidine Sedation on the PICU Patients-A Randomized, Controlled Study. Unknown status NCT02296073 Phase 4 Midazolam;Dexmedetomidine;Dexmedetomidine;Dexmedetomidine;Fentanyl
9 The Pharmacokinetics of Fentanyl in Intensive Care Patients Unknown status NCT02587273 Phase 4 Fentanyl
10 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
11 Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy Unknown status NCT03288428 Phase 4 Nalbuphine;Morphine
12 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
13 Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy Unknown status NCT02523846 Phase 4 morphine
14 Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery Unknown status NCT03014713 Phase 4 Dezocine;Flubiprofen;Dexmedetomidine
15 Opioid-sparing Effect of Intravenous Ibuprofen Unknown status NCT03016650 Phase 4 Acetaminophen;Ibuprofen
16 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
17 The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery Unknown status NCT02503826 Phase 4 Sufentanil;Sufentanil;Sufentanil;Midazolam;propofol;cisatracurium
18 A Prospective, Randomized, Control Trial of Ketorolac Versus Placebo on Opioid Analgesic Use and Complications Following Cesarean Delivery With Intra-Epidural Morphine Unknown status NCT02509312 Phase 4 Ketorolac;Epidural Morphine;Hydromorphone
19 Analgesia After Total Knee Arthroplasty: Randomized Controlled Trial Comparing (a) Periarticular Multimodal Technique With (B) Continuous Femoral Nerve Block + Posterior Capsular Injection Unknown status NCT00869037 Phase 4 Periarticular Injection;CFNB + Posterior Capsular Injection
20 Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. Unknown status NCT00532662 Phase 4 S(+)-ketamine
21 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
22 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
23 A Placebo-controlled, Double-blinded, Randomized Pilot Study of Bupivacaine Liposome Injectable Suspension (EXPAREL) for Minimally Invasive Supracervical Hysterectomies Postsurgical Analgesia Unknown status NCT03769714 Phase 4 Saline Solution for Injection;Exparel
24 Assessment of Analgesic Efficacy and Safety of Intravenous Hyoscine-N-Butylbromide in Patients With Abdominal Colic Associated With Acute Gastroenteritis; a Randomized, Double-blind, Placebo Controlled Study Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
25 Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study Unknown status NCT02733835 Phase 4 Remifentanil
26 Determination of the Minimum Local Analgesic Dose of Spinal Chloroprocaine in Labour. Unknown status NCT01909089 Phase 4 Spinal administration of chloroprocaine.
27 Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery Unknown status NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
28 Effect of Programmed Intermittent Epidural Bolus Delivery Rate on the Quality of Labour Analgesia: A Randomized Clinical Trial Unknown status NCT03712735 Phase 4 Bupivacaine 0.08% - fentanyl 2mcg
29 Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics? - A Pilot Study. Optional Deoxyribo-Nucleic Acid Donation for the Study of Hypertension. Unknown status NCT01715584 Phase 4
30 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
31 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
32 The Effect of Early Goal Directed Sedation on Microcirculation in Septic Shock Patients With Mechanical Ventilation Unknown status NCT02612363 Phase 4 Dexmedetomidine for sedation
33 A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
34 Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
35 The Comparison of Efficacy and Safety of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients --A Randomized Controlled Trial. Unknown status NCT02111265 Phase 4 Remifentanil;Cisatracurium;Sufentanil
36 A Randomized Controlled Trial to Compare the Efficacy and Safety of NALDEBAIN With Intravenous Patient-Controlled Analgesia With Fentanyl for the Treatment of Post-Laparotomy Surgery Unknown status NCT03296488 Phase 4 Nalbuphine Sebacate;Fentanyl Citrate
37 Addition of Magnesium Sulfate to Caudal for Prevention of Emergence Agitation in Children Unknown status NCT02164773 Phase 4 Magnesium Sulfate;0.9%normal saline
38 Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically Unknown status NCT02355093 Phase 4 ropivacaine
39 The Influence of Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by μ-opioid Receptor Agonists Unknown status NCT03135795 Phase 4 Sufentanil;dexmedetomidine;propofol;Rocuronium;sevoflurane;remifentanil;Parecoxib
40 Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial. Unknown status NCT03018171 Phase 4 Clonidine;Sufentanil
41 Post-operative Analgesia Efficacy Using Ultrasound-guided Transmuscular Quadratus Lumborum Block Versus Ultrasound-guided Quadratus Lumborum Type II Block. Unknown status NCT03100994 Phase 4 Bupivacaine
42 Prospective Evaluation of Topical Analgesia Using a Lidocaine/Prilocaine Cream for Laceration Repair in the Emergency Department Unknown status NCT03071601 Phase 4 Lidocaine-Prilocaine Cream 2.5-2.5%;Lidocaine 1% Epinephrine 0.005mg/mL solution
43 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
44 Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery. Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
45 The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy Unknown status NCT03831321 Phase 4 Diclofenac Sodium;Lubricant Gel
46 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
47 The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia:A Randomized, Double Blind Controlled Trial Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
48 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
49 Effect of Preoperative Administration of Oral Pregabalin on the Postoperative Analgesia in Patients Scheduled for Radiofrequency Ablationof Focal Lesions in the Liver Unknown status NCT03151213 Phase 4 Pregabalin 150mg
50 Impact of Nociceptive-Level (NOL) Intraoperative Guided Analgesia on Pain Scores, Opioid Consumption and Recovery in Postoperative Care Unit in Patients Undergoing Gynecological Laparoscopic Surgery Under General Anesthesia. The NOLGYN Pilot Study Unknown status NCT03776838 Phase 4 Intravenous Fentanyl guided by SoC+NOL;Intravenous Fentanyl guided by SoC

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

40
Brain, Breast, Spinal Cord, Skin, Liver, Colon, Prostate

Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30003)
# Title Authors PMID Year
1
Erector spinae plane block combined with local infiltration analgesia for total hip arthroplasty: A randomized, placebo controlled, clinical trial. 61
33296786 2021
2
Minimizing the need for high dependency unit support in adolescent idiopathic scoliosis surgery. Is enhanced recovery and the multidisciplinary team key? 61
32694433 2021
3
Epidural analgesia for postoperative pain: Improving outcomes or adding risks? 61
33742578 2021
4
Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia. 61
33607165 2021
5
"Dual Subsartorial Block (DSB)": An innovative procedure-specific, motor-sparing and opioid-sparing regional analgesia technique for Total knee replacement surgery - A pilot study. 61
33310374 2021
6
A measure of expectancies for alcohol analgesia: Preliminary factor analysis, reliability, and validity. 61
33460990 2021
7
A Survey of the Practice of Thoracic Anesthesia in India. 61
32919834 2021
8
Race and Insurance Status are Associated With Different Management Strategies After Thoracic Trauma. 61
33401122 2021
9
Intercostal Blocks with Liposomal Bupivacaine in Thoracic Surgery: A Retrospective Cohort Study. 61
33067088 2021
10
Liposomal Bupivacaine Versus Bupivacaine Hydrochloride for Intercostal Nerve Blockade in Minimally Invasive Thoracic Surgery. 61
33376072 2021
11
Dermatomal coverage of single-injection ultrasound-guided parasagittal approach to anterior quadratus lumborum block at the lateral supra-arcuate ligament. 61
33550463 2021
12
Sublingual Sufentanil Tablet System Versus Continuous Morphine Infusion for Postoperative Analgesia in Cardiac Surgery Patients. 61
32951999 2021
13
Bilateral mandibular block improves pain relief and morphine consumption in mandibular osteotomies: a prospective, randomized, double-blind, placebo-controlled clinical trial. 61
33563767 2021
14
Surgeon-Placed Continuous Wound Infusion Pain Catheters Markedly Decrease Narcotic Use and Improve Outcomes After Pancreatic Tumor Resection. 61
32880771 2021
15
Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. 61
33485984 2021
16
Update on medical management of acute hip fracture. 61
33795248 2021
17
Concerns for labor analgesia and autism spectrum disorders. 61
33236241 2021
18
The music video therapy in postoperative analgesia in preschool children after cardiothoracic surgery. 61
33811684 2021
19
Impact of anxiety levels on the perception of pain in patients undergoing office hysteroscopy. 61
33211175 2021
20
Hypnotic Enhancement of Virtual Reality Distraction Analgesia during Thermal Pain: A Randomized Trial. 61
33724890 2021
21
Ultrasound-guided transversalis fascia plane block versus transmuscular quadratus lumborum block for post-operative analgesia in inguinal hernia repair. 61
33785672 2021
22
Effect of Dural Puncture Epidural Technique Combined With Programmed Intermittent Epidural Bolus on Labor Analgesia Onset and Maintenance: A Randomized Controlled Trial. 61
32282386 2021
23
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain. 61
33181192 2021
24
Subcostal Anterior Quadratus Lumborum Block Versus Epidural Block for Analgesia in Open Nephrectomy: A Randomized Clinical Trial. 61
33617181 2021
25
Uncovering the use and misuse of opioid analgesia in a pregnant and non-pregnant female population. 61
31959725 2021
26
Perioperative Analgesia in Neurosurgery (PAIN): A national survey of pain assessment and management among neuroanesthesiologists of India. 61
32966673 2021
27
Ketamine-polymer based drug delivery system for prolonged analgesia: recent advances, challenges and future prospects. 61
33599572 2021
28
Perioperative pediatric tonsillectomy analgesia: A single-center review of practice and cost-effectiveness analysis. 61
33484060 2021
29
Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study. 61
32875383 2021
30
Intravenous patient-controlled analgesia hydromorphone combined with pregabalin for the treatment of postherpetic neuralgia: a multicenter, randomized controlled study. 61
33785673 2021
31
Intra-articular infiltration analgesia for arthroscopic shoulder surgery: a systematic review and meta-analysis. 61
32596840 2021
32
The association between labour epidural analgesia and postpartum depressive symptoms: a longitudinal cohort study. 61
33403538 2021
33
Is preemptive analgesia a good choice for postoperative pain relief in lumbar spine surgeries?: A meta-analysis of randomized controlled trials. 61
33787624 2021
34
Comment on the editorial relating to: Transversus abdominis plane block compared with wound infiltration for postoperative analgesia following Cesarean delivery: a systematic review and network meta-analysis. 61
33403553 2021
35
Intracranial hematoma and abscess after neuraxial analgesia and anesthesia: a review of the literature describing 297 cases. 61
33441431 2021
36
In reply: Comment on the editorial relating to: Transversus abdominis plane block compared with wound infiltration for postoperative analgesia following Cesarean delivery: a systematic review and network meta-analysis. 61
33403542 2021
37
Continuous erector spinae plane blocks with automated boluses for analgesia following percutaneous nephrolithotomy. 61
32773726 2021
38
Offset analgesia is reduced on the palm and increases with stimulus duration. 61
33290593 2021
39
Intrauterine contraction parameters at baseline and following epidural and combined spinal-epidural analgesia: A repeated measures comparison. 61
33596500 2021
40
Photoplethysmography-derived approximate entropy and sample entropy as measures of analgesia depth during propofol-remifentanil anesthesia. 61
32026257 2021
41
Efficiency and safety: comparison between preoperative analgesia and postoperative analgesia using non-steroidal anti-inflammatory drugs in patients receiving arthroscopic knee surgery in a multicenter, randomized, controlled study. 61
33797658 2021
42
Characterizing Pain in Children with Acute Gastroenteritis Who Present for Emergency Care. 61
33333114 2021
43
Combining high-intensity focused ultrasound (HIFU) ablation with percutaneous ethanol injection (PEI) in the treatment of benign thyroid nodules. 61
32974689 2021
44
The Implementation of an Acute Pain Service for Patients Undergoing Open Ventral Hernia Repair with Mesh and Abdominal Wall Reconstruction. 61
33454790 2021
45
Birth plan presentation to hospitals and its relation to obstetric outcomes and selected pain relief methods during childbirth. 61
33794803 2021
46
Postpartum urinary retention: Absolute risk prediction model. 61
33118328 2021
47
Patterns of dispensed opioids after tonsillectomy in children and adolescents in South Carolina, United States, 2010-2017. 61
33548590 2021
48
Translational value of non-human primates in opioid research. 61
33453211 2021
49
Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats. 61
33110031 2021
50
Can Acetaminophen Pretreatment Decrease the Pain Associated With Closed Nasal Bone Reduction? A Triple-Blind Randomized Clinical Trial. 61
33359106 2021

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

Pathways related to Pain Agnosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 TAC1 POMC PNOC PENK PDYN OXT
2
Show member pathways
12.72 TRPV1 TAC1 POMC PNOC PENK PDYN
3 12.27 SCN9A POMC OPRM1 CALCA
4
Show member pathways
12.17 POMC PDYN OPRM1 ARRB2
5
Show member pathways
12.11 OXT FOS CALCA ARRB2
6 11.64 POMC OPRM1 FOS
7 11.4 POMC FOS ARRB2
8 10 TAC1 ARRB2

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 TAC1 POMC PNOC PENK PDYN OXT
2 axon GO:0030424 9.85 TAC1 SCN9A PENK OPRM1 CCK CALCA
3 neuron projection GO:0043005 9.8 TRPV1 SCN9A OPRM1 OPRL1 OPRK1 FOS
4 dendrite GO:0030425 9.76 TRPV1 PNOC PENK PDYN OPRM1 OPRK1
5 perikaryon GO:0043204 9.72 PENK OPRM1 OPRK1 NPFF CCK
6 terminal bouton GO:0043195 9.61 OXT CCK CALCA
7 axon terminus GO:0043679 9.35 PNOC PENK PDYN OPRK1 NPFF
8 neuronal cell body GO:0043025 9.23 TRPV1 TAC1 PNOC PENK PDYN OPRK1

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.28 POMC PNOC PENK OXT OPRM1 OPRL1
2 G protein-coupled receptor signaling pathway GO:0007186 10.13 TAC1 POMC PNOC PENK PDYN OXT
3 inflammatory response GO:0006954 10.04 TRPV1 TAC1 SCN9A FOS CALCA
4 chemical synaptic transmission GO:0007268 9.95 TAC1 PNOC PENK PDYN OPRK1 NPFF
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.93 TRPV1 TAC1 OXT OPRM1 NPFF CALCA
6 response to lipopolysaccharide GO:0032496 9.92 TAC1 PENK OPRM1 FOS
7 response to ethanol GO:0045471 9.87 PENK OPRM1 OPRK1
8 response to estradiol GO:0032355 9.87 PENK OXT OPRL1
9 female pregnancy GO:0007565 9.85 PNOC OXT FOS
10 response to toxic substance GO:0009636 9.85 SCN9A PENK FOS
11 regulation of blood pressure GO:0008217 9.83 TAC1 POMC CALCA
12 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.83 OPRM1 OPRL1 OPRK1
13 excitatory postsynaptic potential GO:0060079 9.83 TRPV1 OPRM1 NPFF ARRB2
14 response to morphine GO:0043278 9.8 TAC1 PENK OPRM1 OPRK1 NPFF
15 response to cocaine GO:0042220 9.79 OXT OPRM1 OPRK1
16 cellular response to nerve growth factor stimulus GO:1990090 9.79 TRPV1 TAC1 CALCA
17 eating behavior GO:0042755 9.77 OXT OPRM1 OPRL1 OPRK1 CCK
18 response to radiation GO:0009314 9.76 PENK OPRM1 OPRK1
19 negative regulation of blood pressure GO:0045776 9.75 OXT OPRL1 CALCA
20 response to pain GO:0048265 9.73 TRPV1 TRPA1 TAC1 CALCA
21 regulation of sensory perception of pain GO:0051930 9.73 OXT OPRM1 OPRL1 OPRK1 NPFF CCK
22 estrous cycle GO:0044849 9.72 OPRM1 OPRL1 OPRK1
23 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.71 TRPV1 CALCA ARRB2
24 negative regulation of cAMP-mediated signaling GO:0043951 9.7 OPRM1 OPRL1
25 positive regulation of ossification GO:0045778 9.69 TAC1 OXT
26 behavior GO:0007610 9.69 OPRL1 OPRK1
27 negative regulation of heart rate GO:0010459 9.69 TRPV1 TAC1 NPFF
28 positive regulation of renal sodium excretion GO:0035815 9.68 TAC1 OXT
29 G protein-coupled receptor internalization GO:0002031 9.68 CALCA ARRB2
30 behavioral response to pain GO:0048266 9.67 TRPV1 SCN9A
31 maternal behavior GO:0042711 9.67 OXT OPRK1
32 sleep GO:0030431 9.67 OXT FOS
33 opioid receptor signaling pathway GO:0038003 9.67 OPRM1 OPRL1 OPRK1
34 negative regulation of appetite GO:0032099 9.66 NPFF CCK
35 positive regulation of behavioral fear response GO:2000987 9.65 PENK CCK
36 positive regulation of sensory perception of pain GO:1904058 9.65 OPRL1 CCK
37 acute inflammatory response to antigenic stimulus GO:0002438 9.64 OPRM1 NPFF
38 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.63 OPRM1 OPRL1
39 sensory perception GO:0007600 9.63 PNOC PENK PDYN OPRM1 OPRL1 OPRK1
40 conditioned place preference GO:1990708 9.61 OPRL1 OPRK1
41 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.6 TRPV1 TRPA1
42 thermoception GO:0050955 9.59 TRPV1 TRPA1
43 positive regulation of gastric acid secretion GO:0060454 9.57 TRPV1 OPRL1
44 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.56 OPRM1 OPRK1
45 sensory perception of pain GO:0019233 9.56 TRPV1 TRPA1 TAC1 SCN9A PENK OPRM1
46 neuropeptide signaling pathway GO:0007218 9.32 TAC1 POMC PNOC PENK PDYN OPRM1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.67 POMC OXT CCK CALCA
2 G protein-coupled receptor binding GO:0001664 9.61 POMC NPFF ARRB2
3 peptide binding GO:0042277 9.58 OPRM1 OPRL1 OPRK1
4 neuropeptide binding GO:0042923 9.5 OPRM1 OPRL1 OPRK1
5 calcium-release channel activity GO:0015278 9.46 TRPV1 TRPA1
6 opioid receptor activity GO:0004985 9.43 OPRM1 OPRL1 OPRK1
7 opioid receptor binding GO:0031628 9.33 PNOC PENK PDYN
8 opioid peptide activity GO:0001515 9.13 PNOC PENK PDYN
9 neuropeptide hormone activity GO:0005184 9.02 PNOC PENK OXT NPFF CCK

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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