MCID: PNG002
MIFTS: 50

Pain Agnosia

Categories: Mental diseases
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Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 11 14 16
Analgesia 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology: 11 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary: Pain Agnosia, also known as analgesia, is related to episodic pain syndrome, familial, 1 and chronic pain. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Benzoic acid and Mineral oil have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and liver, and related phenotypes are nervous system and normal

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1174)
# Related Disease Score Top Affiliating Genes
1 episodic pain syndrome, familial, 1 32.1 TRPV1 TRPA1 SCN9A
2 chronic pain 32.0 SCN9A OPRM1
3 ileus 31.6 OPRM1 IL6 CALCA
4 inguinal hernia 31.5 TCF21 POMC IL6
5 amnestic disorder 31.4 PDYN OXT OPRM1 FOS
6 postpartum depression 31.3 POMC PNOC OXT IL6
7 paine syndrome 31.0 TRPV1 TRPA1 TAC1 SCN9A POMC PNOC
8 opiate dependence 31.0 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
9 withdrawal disorder 31.0 POMC PNOC PDYN OPRM1 OPRK1 NPFF
10 radiculopathy 30.9 TAC1 IL6 CALCA
11 fibromyalgia 30.9 SCN9A POMC PNOC OXT OPRM1 IL6
12 trigeminal neuralgia 30.8 TRPV1 TRPA1 TAC1 SCN9A CALCA
13 paralytic ileus 30.8 TCF21 TAC1 IL6 CALCA
14 complex regional pain syndrome 30.8 TRPV1 TRPA1 TAC1 SCN9A OPRM1 IL6
15 post-traumatic stress disorder 30.8 POMC OXT IL6 FOS FAAH
16 alcohol use disorder 30.8 POMC PDYN OPRM1 IL6
17 leptin deficiency or dysfunction 30.7 POMC OXT IL6 CCK
18 diabetic neuropathy 30.7 TRPV1 TRPA1 TAC1 SCN9A CALCA
19 reflex sympathetic dystrophy 30.7 TRPV1 TAC1 SCN9A CALCA
20 major depressive disorder 30.7 TAC1 POMC PDYN OXT OPRM1 IL6
21 arachnoiditis 30.6 TAC1 POMC
22 irritable bowel syndrome 30.6 TRPV1 TRPA1 TAC1 POMC IL6 FOS
23 motion sickness 30.6 TAC1 POMC OPRM1 FOS
24 morphine dependence 30.6 PDYN OXT OPRM1 OPRK1 FOS CCK
25 mononeuropathy 30.6 TRPV1 TAC1 IL6 CALCA
26 cystitis 30.5 TRPV1 TAC1 IL6
27 persistent fetal circulation syndrome 30.5 POMC OXT IL6
28 duodenal ulcer 30.5 IL6 CCK CALCA
29 acute stress disorder 30.5 POMC OXT
30 bowel dysfunction 30.4 TRPV1 TAC1 SAG POMC OPRM1 OPRK1
31 opioid abuse 30.4 TAC1 SAG POMC PNOC PDYN OPRM1
32 peripheral nervous system disease 30.4 TRPV1 TRPA1 TAC1 SCN9A POMC OPRM1
33 mood disorder 30.4 POMC PDYN OXT IL6
34 alcohol dependence 30.4 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
35 substance abuse 30.4 POMC PDYN OXT OPRM1 OPRK1 IL6
36 panic disorder 30.4 TAC1 POMC IL6 CCK
37 anxiety 30.4 TRPV1 TAC1 POMC PNOC PDYN OXT
38 diabetes insipidus 30.3 SAG POMC OXT CALCA
39 diarrhea 30.3 TRPV1 TAC1 IL6 CCK CALCA
40 drug dependence 30.3 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
41 bell's palsy 30.3 LIPN IL6
42 neurogenic bladder 30.2 TRPV1 TAC1 CALCA
43 frozen shoulder 30.2 TAC1 IL6 CALCA
44 epilepsy 30.2 SCN9A POMC PDYN OPRM1 IL6 CCK
45 spondylosis 30.2 TAC1 LIPN IL6
46 erythromelalgia 30.2 TRPV1 TRPA1 TAC1 SCN9A
47 aspiration pneumonitis 30.2 OXT IL6
48 mediastinitis 30.2 TCF21 IL6
49 psychotic disorder 30.2 PDYN OXT OPRM1 IL6 FOS CCK
50 bronchitis 30.2 TAC1 IL6 CALCA

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.24 CALCA CCK FAAH FOS IL6 OPRK1
2 normal MP:0002873 10.06 CALCA FAAH FOS OPRL1 OPRM1 SCN9A
3 homeostasis/metabolism MP:0005376 10.06 CALCA CCK FAAH FOS IL6 LIPN
4 renal/urinary system MP:0005367 9.97 CALCA CCK IL6 OXT POMC SCN9A
5 adipose tissue MP:0005375 9.91 FOS IL6 OPRM1 OXT PDYN POMC
6 behavior/neurological MP:0005386 9.86 CALCA FAAH FOS IL6 NPFF OPRK1
7 integument MP:0010771 9.53 CALCA FAAH FOS IL6 OPRK1 OPRL1

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 355)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
2
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
3
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3 6337
4
Metamizole Approved, Investigational, Withdrawn Phase 4 50567-35-6 3111 522325
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Dimenhydrinate Approved Phase 4 523-87-5 10660
7
Orphenadrine Approved Phase 4 83-98-7 4601
8
Ondansetron Approved, Withdrawn Phase 4 99614-02-5 4595
9
Racephedrine Approved, Experimental Phase 4 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
10
Glycopyrronium Approved, Investigational, Vet_approved Phase 4 596-51-0, 740028-90-4 3494
11
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
14
Nalbuphine Approved Phase 4 20594-83-6 5311304
15
Meperidine Approved Phase 4 57-42-1 4058
16
Esmolol Approved, Withdrawn Phase 4 103598-03-4, 81147-92-4 59768
17
Prilocaine Approved Phase 4 721-50-6 4906
18
Salmon calcitonin Approved, Investigational Phase 4 47931-85-1 155817456
19
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
20
Parecoxib Approved Phase 4 198470-84-7 119828
21
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
22
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
23
Pentazocine Approved, Vet_approved Phase 4 359-83-1 4736 441278
24
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-56-5 148211 6337614
25
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
26
Nitric Oxide Approved Phase 4 10102-43-9 145068
27
Vecuronium Approved, Investigational Phase 4 50700-72-6, 86029-43-8 39765 39764
28
Famotidine Approved Phase 4 76824-35-6 3325 5702160
29
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
30
Methoxyflurane Approved, Investigational, Vet_approved, Withdrawn Phase 4 76-38-0 4116
31
Desflurane Approved Phase 4 57041-67-5 42113
32
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
33
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
34
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
35
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
36
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
37
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
38
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
39
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
40
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
41
Granisetron Approved, Investigational Phase 4 109889-09-0 3510 5284566
42
Scopolamine Approved, Investigational Phase 4 51-34-3 153311 3000322
43
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
44
Cyclobenzaprine Approved Phase 4 303-53-7 2895
45
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
46
Pancrelipase Approved, Investigational Phase 4 53608-75-6 8519
47
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
48
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
49
Butorphanol Approved, Illicit, Vet_approved Phase 4 58786-99-5, 42408-82-2 5361092
50
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053

Interventional clinical trials:

(show top 50) (show all 2501)
# Name Status NCT ID Phase Drugs
1 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
2 Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy Unknown status NCT02523846 Phase 4 morphine
3 Opioid-sparing Effect of Intravenous Ibuprofen Unknown status NCT03016650 Phase 4 Acetaminophen;Ibuprofen
4 Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults Unknown status NCT03901612 Phase 4 Ropivacaine 0.2%;saline 09%
5 Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation: a Prospective, Randomized, Multicenter Clinical Study Unknown status NCT04315935 Phase 4 Butorphanol and Propofol;Fentanyl and Propofol
6 Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery Unknown status NCT03014713 Phase 4 Dezocine;Flubiprofen;Dexmedetomidine
7 Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. Unknown status NCT00532662 Phase 4 S(+)-ketamine
8 Analgesia After Total Knee Arthroplasty: Randomized Controlled Trial Comparing (a) Periarticular Multimodal Technique With (B) Continuous Femoral Nerve Block + Posterior Capsular Injection Unknown status NCT00869037 Phase 4 Periarticular Injection;CFNB + Posterior Capsular Injection
9 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
10 The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery Unknown status NCT02503826 Phase 4 Sufentanil;Midazolam;propofol;cisatracurium
11 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
12 Efficacy of Lidocaine as Local Anesthetics in Children Under Procedural Sedation and Analgesia Using Ketamine Unknown status NCT02205502 Phase 4 Lidocaine;Normal saline
13 The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy Unknown status NCT03831321 Phase 4 Diclofenac Sodium;Lubricant Gel
14 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
15 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
16 A Randomized Controlled Trial to Compare the Efficacy and Safety of NALDEBAIN With Intravenous Patient-Controlled Analgesia With Fentanyl for the Treatment of Post-Laparotomy Surgery Unknown status NCT03296488 Phase 4 Nalbuphine Sebacate;Fentanyl Citrate
17 Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy Unknown status NCT03288428 Phase 4 Nalbuphine;Morphine
18 Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia After Spontaneous Vaginal Birth in Obese Women: A Randomised Controlled Trial Unknown status NCT03694873 Phase 4 Tramadol Hydrochloride;Celecoxib 200mg
19 Intravenous Lidocaine for Perioperative and Postoperative Analgesia Unknown status NCT03921567 Phase 4 Lidocaine Hydrochloride;Lidocaine Hydrochloride and Ketamine;Placebo
20 Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study Unknown status NCT02733835 Phase 4 Remifentanil
21 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
22 Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial. Unknown status NCT03018171 Phase 4 Clonidine;Sufentanil
23 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
24 Opioid-Sparing Protocol Using for Postoperative Pain Management Comparing With Opioid-based Patient Control Analgesia After Simultaneous Bilateral Total Knee Arthroplasty: a Randomized Controlled Trial Unknown status NCT04314505 Phase 4 Opioid-Sparing Protocol;Opioid-Based Patient Controlled Analgesia
25 A Placebo-controlled, Double-blinded, Randomized Pilot Study of Bupivacaine Liposome Injectable Suspension (EXPAREL) for Minimally Invasive Supracervical Hysterectomies Postsurgical Analgesia Unknown status NCT03769714 Phase 4 Saline Solution for Injection;Exparel
26 Oral Phenazopyridine Versus Intravesical Lidocaine for Office OnabotulinumtoxinA Analgesia: A Randomized Controlled Trial Unknown status NCT03755089 Phase 4 Phenazopyridine;Lidocaine 2% Injectable Solution
27 the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation Unknown status NCT02635802 Phase 4 Remifentanil;Lidocaine;Remifentanil+Lidocaine;Midazolam
28 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;opioid
29 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
30 The Effect of Intrathecal Versus Intravenous Dexmeditomedine on Postoperative Analgesia in Transurethral Resection of the Prostate Unknown status NCT04618965 Phase 4 control group;Intrathecal dexmedetomidine;Intravenous dexmedetomidine
31 Comparison of the Postoperative Analgesia Effectiveness of Preemptive Intravenous Ibuprofen and Paracetamol in Patients Undergoing Laparoscopic Cholecystectomy Unknown status NCT03063658 Phase 4 Paracetamol;Ibuprofen 800 mg
32 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
33 Comparing the Delivery of Local Anesthetic by Programmed Intermittent Bolus Versus Continuous Infusion Through a Popliteal Sciatic Nerve Catheter for Analgesia Following Major Ankle Surgery Unknown status NCT02707874 Phase 4 CI 0.2% ropivacaine;PIB 0.2% ropivacaine
34 Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery - a Randomized, Blinded, Placebo Controlled Study Unknown status NCT02576223 Phase 4 Ropivacaine hydrochloride;Isotonic Saline
35 Comparison of the ED95 Dose of 0.075% and 0.1% Bupivacaine for Labour Analgesia in Primigravida. Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
36 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
37 Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery: A Randomized Single Blinded Control Trial Unknown status NCT02672813 Phase 4
38 Correlation Between Acute Analgesia and Long-Term Function Following Ankle Unknown status NCT02667730 Phase 4 Acetaminophen;Naproxen;Celecoxib
39 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
40 Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
41 Randomised Controlled Trial Comparing the Effect of Intravenous Dexamethasone vs. Placebo on the Duration of Analgesia of Spinal Anaesthesia for Caesarean Sections at the Victoria Jubilee Hospital in Jamaica Unknown status NCT04624360 Phase 4 Dexamethasone
42 Effects of Intranasal Injection of Dexmedetomidine Plus Bupivacaine on Anesthesia & Analgesia in Septoplasty Surgeries Unknown status NCT03926663 Phase 4 Dexmedetomidine;Bupivacaine
43 Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
44 Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection Unknown status NCT00822133 Phase 4 lidocaine;ketamine;non-active drug cream
45 Post-operative Analgesia Efficacy Using Ultrasound-guided Transmuscular Quadratus Lumborum Block Versus Ultrasound-guided Quadratus Lumborum Type II Block. Unknown status NCT03100994 Phase 4 Bupivacaine
46 The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia:A Randomized, Double Blind Controlled Trial Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
47 Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy: a Prospective, Randomized, Double-blind Study. Unknown status NCT03394001 Phase 4 Lidocaine Hydrochloride;Ketorolac tromethamine
48 A Pilot Study for a Prospective, Randomized Controlled Trial of Techniques for Perioperative Analgesia for Live Liver Donors Unknown status NCT03393988 Phase 4 Fentanyl infusion;Dexmedetomidine
49 Effect of Preoperative Administration of Oral Pregabalin on the Postoperative Analgesia in Patients Scheduled for Radiofrequency Ablationof Focal Lesions in the Liver Unknown status NCT03151213 Phase 4 Pregabalin 150mg
50 The Study of Perioperative Intravenous Infusion of Lidocaine on Postoperative Analgesia in Patients Undergoing Single-port Thoracoscopic Unknown status NCT04043624 Phase 4 Lidocaine;Saline

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

Organs/tissues related to Pain Agnosia:

MalaCards : Breast, Brain, Liver, Skin, Colon, Lung, Heart

Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30003)
# Title Authors PMID Year
1
Evaluating the role for regional analgesia in children with spina bifida: a retrospective observational study comparing the efficacy of regional versus systemic analgesia protocols following major urological surgery. 62
36167478 2023
2
Blockade of the orexin receptors in the ventral tegmental area could attenuate the stress-induced analgesia: A behavioral and molecular study. 62
36116673 2023
3
A novel anti-NGF PEGylated Fab' provides analgesia with lower risk of adverse effects. 62
36458900 2023
4
Hystricomorph Rodent Analgesia. 62
36402480 2023
5
PENG block: a possible ally of the multimodal analgesia. 62
36261262 2023
6
Ultrasound-guided selective peripheral nerve block compared with the sub-dissociative dose of ketamine for analgesia in patients with extremity injuries. 62
36332503 2023
7
Association of anesthesia and analgesia with long-term mortality after hip fracture surgery: an analysis of the Australian and New Zealand hip fracture registry. 62
36137734 2023
8
Dexamethasone Does Not Provide Additional Clinical Analgesia Effect to Local Wound Infiltration: A Comprehensive Systematic Review and Meta-Analysis. 62
35081741 2023
9
Comparison of Ketamine, Dexmedetomidine and Lidocaine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial. 62
35382963 2022
10
Efficacy of Electroacupuncture Combined with Intravenous Patient-controlled Analgesia after Cesarean Section: A Randomized Clinical Trial. 62
36464237 2022
11
Efficacy of postoperative analgesia with duloxetine in posthemorrhoidectomy pain: a prospective, randomized, double-blind and placebo-controlled trial. 62
36457090 2022
12
Pain analgesia or desensitization? A longitudinal lab-based study on the link between pain and nonsuicidal self-injury. 62
36384068 2022
13
Effects of Systemic Lidocaine Versus Dexmedetomidine on the Recovery Quality and Analgesia After Thyroid Cancer Surgery: A Randomized Controlled Trial. 62
36203077 2022
14
Implementation of a perioperative pain management algorithm reduces the use of opioid analgesia following pelvic exenteration surgery. 62
36461690 2022
15
CYP2D in the brain impacts oral hydrocodone analgesia in vivo. 62
36241086 2022
16
Comparison of Femoral Nerve Catheter, Adductor Canal Catheter, and Periarticular Liposomal Bupivacaine Infiltration for Postoperative Analgesia after Primary Total Knee Arthroplasty. 62
36470364 2022
17
Hepatic Hilar Nerve Block for Adjunctive Analgesia during Percutaneous Thermal Ablation of Hepatic Tumors: a Retrospective Analysis. 62
36473614 2022
18
Differential Effects of Cannabidiol and a Novel Cannabidiol Analog on Oxycodone Place Preference and Analgesia in Mice: an Opioid Abuse Deterrent with Analgesic Properties. 62
34962133 2022
19
Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis. 62
36404458 2022
20
How painful are cats after neutering - a field study using multimodal analgesia with intraperitoneal ropivacaine in a -neuter-return program in feral cats. 62
36454013 2022
21
Does local infiltration analgesia in total joint arthroplasty offer any protection from prosthetic joint infections? An invitro experimental study. 62
36453651 2022
22
Wearable, Noninvasive, Pulsed Shortwave (Radiofrequency) Therapy for Analgesia and Opioid Sparing following Outpatient Surgery: A Proof-of-Concept Case Series. 62
36463434 2022
23
A retrospective review of post-intubation sedation and analgesia practices in a South African private ambulance service. 62
36415448 2022
24
Hot Off the Press! Commentary on "Maternal Fever Associated With Continuous Spinal Versus Epidural Labor Analgesia: A Single-Center Retrospective Study". 62
36384011 2022
25
Analgesia as part of the orotracheal intubation induction sequence. 62
36194259 2022
26
Local infiltration of HYR-PB21, a sustained-release formulation of bupivacaine, provides analgesia and reduces opioid requirement after haemorrhoidectomy: a randomised controlled trial. 62
36243580 2022
27
Inter-semispinal plane (ISP) block for postoperative analgesia following cervical spine surgery: A prospective randomized controlled trial. 62
36228453 2022
28
Opioid-free analgesia: is it achievable in open colorectal surgery without neuraxial block? 62
36193955 2022
29
Periarticular multimodal analgesia in decreasing perioperative pain in tibial plateau fractures: A double blind randomized controlled pilot study. 62
36207154 2022
30
Prolonged duration of epidural labour analgesia decreases the success rate of epidural anaesthesia for caesarean section. 62
35443838 2022
31
A standardized post-cesarean analgesia regimen reduces postpartum opioid use. 62
34445918 2022
32
Ultrasound-guided quadratus lumborum block provided more effective analgesia for children undergoing lower abdominal laparoscopic surgery: a randomized clinical trial. 62
35764836 2022
33
ASO Author Reflections: Non-Steroidal Anti-Inflammatory Drugs are Safe in the Post-Discharge Setting After Lumpectomy and Sentinel Lymph Node Biopsy with Multimodal Analgesia. 62
34387771 2022
34
Methylene Blue Combined with Ropivacaine for Intercostal Nerve Block After Autologous Costal Cartilage Removal in Juvenile Patients. 62
36109354 2022
35
Future liver remnant volume is associated with postoperative fentanyl consumption following open donor hepatectomy: a retrospective multivariate analysis. 62
36190573 2022
36
Efficacy of ultrasound-guided single-injection erector spinae plane block for thoracoscopic wedge resection: a prospective randomized control trial. 62
36150741 2022
37
Association of pain, analgesic, psychological, and socioeconomic factors with sub-acute pain after childbirth: A prospective cohort study. 62
36208586 2022
38
Methadone rotation for cancer pain: an observational study. 62
32321728 2022
39
An Enhanced Recovery After Surgery protocol for robotic-assisted laparoscopic nephrectomies utilizing a quadratus lumborum block. 62
35142979 2022
40
Feasibility and efficacy of erector spinae plane block versus transversus abdominis plane block in laparoscopic bariatric surgery: a randomized comparative trial. 62
35581710 2022
41
Plasmatic catecholamines after neuraxial labour analgesia: A randomised controlled trial comparing epidural versus combined spinal-epidural. 62
36067925 2022
42
Prevention and treatment of pediatric pain and anxiety caused by botulinum neurotoxin A injections: Inadmissible without nitrous oxide analgesia and sedation? 62
36089662 2022
43
Changes in sensory block level during a programmed intermittent epidural bolus regimen for labour analgesia: a prospective observational cohort study. 62
36076123 2022
44
Comparison Between Periarticular Analgesia Versus Intraarticular Injection for Effectiveness and Safety After Total Knee Arthroplasty. 62
36123240 2022
45
A Randomized Controlled Pilot Study Using Ultrasound-Guided Percutaneous Cryoneurolysis of the Infrapatellar Branch of the Saphenous Nerve for Analgesia Following Total Knee Arthroplasty. 62
36018541 2022
46
Effect of analgesia with pethidine during labour on false positivity of newborn hearing screening test. 62
33882796 2022
47
Advantages of Transmuscular Quadratus Lumborum Block via Subfascial Approach Versus Extrafascial Approach for Postoperative Analgesia After Laparoscopic Cholecystectomy: A Randomized Controlled Study. 62
36221155 2022
48
Antagonism of the orexin receptors in the ventral tegmental area diminished the stress-induced analgesia in persistent inflammatory pain. 62
36155089 2022
49
Ultrasound-Guided Anterior Quadratus Lumborum Block at Lateral Supra-Arcuate Ligament vs Thoracic Epidural Analgesia after Open Liver Surgery: A Randomized, Controlled, Noninferiority Trial. 62
36102582 2022
50
Paravertebral block versus erector spinae plane block for analgesia in modified radical mastectomy: a randomized, prospective, double-blind study. 62
36282220 2022

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 10 TRPV1 PNOC PDYN OPRM1 OPRK1 NPFF
2 neuronal cell body GO:0043025 9.9 CALCA OPRK1 PDYN PNOC TAC1 TRPV1
3 axon terminus GO:0043679 9.56 PNOC PDYN OPRK1 NPFF
4 neuron projection GO:0043005 9.36 TRPV1 SCN9A OPRM1 OPRL1 OPRK1 FOS

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.45 SAG POMC PNOC OXT OPRM1 OPRL1
2 inflammatory response GO:0006954 10.31 CALCA FOS IL6 SCN9A TAC1 TRPV1
3 chemical synaptic transmission GO:0007268 10.3 NPFF OPRK1 PDYN PNOC TAC1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 10.11 TRPV1 TAC1 OXT OPRM1 CALCA
5 response to activity GO:0014823 10.1 OXT IL6 FOS
6 response to cold GO:0009409 10.09 FOS SCN9A TRPA1
7 cellular response to nerve growth factor stimulus GO:1990090 10.05 TRPV1 TAC1 CALCA
8 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 10.04 OPRM1 OPRL1 OPRK1
9 response to heat GO:0009408 10.03 TRPV1 SCN9A CALCA
10 response to cocaine GO:0042220 9.96 OXT OPRM1 OPRK1
11 eating behavior GO:0042755 9.96 CCK OPRK1 OPRL1 OPRM1 OXT
12 negative regulation of blood pressure GO:0045776 9.95 OXT OPRL1 CALCA
13 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.92 OPRM1 OPRL1
14 estrous cycle GO:0044849 9.91 OPRM1 OPRL1 OPRK1
15 regulation of sensory perception of pain GO:0051930 9.91 OXT OPRM1 OPRL1 OPRK1
16 conditioned place preference GO:1990708 9.89 OPRL1 OPRK1
17 thermoception GO:0050955 9.88 TRPV1 TRPA1
18 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.88 TRPV1 SCN9A CALCA
19 G protein-coupled opioid receptor signaling pathway GO:0038003 9.88 OPRK1 OPRL1 OPRM1
20 response to pain GO:0048265 9.87 TRPV1 TRPA1 TAC1 CALCA
21 sensory perception GO:0007600 9.85 PNOC PDYN OPRM1 OPRL1 OPRK1
22 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.84 TRPV1 TRPA1
23 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.83 OPRK1 OPRM1
24 positive regulation of gastric acid secretion GO:0060454 9.81 OPRL1 TRPV1
25 sensory perception of pain GO:0019233 9.77 OPRK1 OPRL1 OPRM1 SCN9A TAC1 TRPA1
26 behavior GO:0007610 9.63 OPRL1 OPRK1
27 neuropeptide signaling pathway GO:0007218 9.58 TAC1 POMC PNOC PDYN OPRM1 OPRL1
28 postsynaptic signal transduction GO:0098926 9.49 OPRK1 OPRM1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.8 POMC OXT CCK CALCA
2 opioid receptor binding GO:0031628 9.67 PNOC PDYN
3 neuropeptide binding GO:0042923 9.63 OPRM1 OPRL1 OPRK1
4 opioid peptide activity GO:0001515 9.62 PNOC PDYN
5 G protein-coupled opioid receptor activity GO:0004985 9.26 OPRM1 OPRL1 OPRK1
6 neuropeptide hormone activity GO:0005184 9.23 PNOC OXT NPFF CCK

Sources for Pain Agnosia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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