Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 15
Analgesia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to chronic pain and constipation. An important gene associated with Pain Agnosia is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 chronic pain 30.6 CNR1 OPRM1
2 constipation 30.5 CCK OPRM1 TAC1
3 anxiety 30.4 CCK CNR1 OPRL1 OXT
4 morphine dependence 30.4 CCK OPRK1 OPRM1 TRPV1
5 opioid abuse 30.3 CCK OPRM1 PDYN
6 opiate dependence 30.0 OPRK1 OPRM1 PDYN POMC
7 opioid addiction 29.7 CCK OPRK1 OPRM1 PNOC
8 agnosia 22.6 AP1M2 AP2M1 CCK CNR1 HTR7 LIPN
9 increased analgesia from kappa-opioid receptor agonist, female-specific 12.0
10 chronic pain requiring intraspinal analgesia 11.9
11 neuropathy, hereditary sensory and autonomic, type v 11.1
12 marsili syndrome 11.0
13 indifference to pain, congenital, autosomal recessive 11.0
14 myofascial pain syndrome 10.9 POMC TAC1
15 cyclic vomiting syndrome 10.9 CNR1 OPRM1
16 autoimmune encephalitis 10.9 CNR1 TRPV1
17 congenital insensitivity to pain with hyperhidrosis 10.9
18 congenital insensitivity to pain with severe intellectual disability 10.9
19 retrograde amnesia 10.9 PDYN POMC
20 stereotypic movement disorder 10.8 CCK TAC1
21 epicondylitis 10.8 LIPN TAC1
22 somatoform disorder 10.8 OPRM1 TAC1 TRPV1
23 neonatal abstinence syndrome 10.8 OPRK1 OPRM1
24 sick building syndrome 10.7 POMC TRPV1
25 pancreas disease 10.7 CCK POMC TRPV1
26 shipyard eye 10.7 PDYN PSENEN
27 overnutrition 10.7 CNR1 POMC TRPV1
28 functional gastric disease 10.7 CCK HTR7 TRPV1
29 amnestic disorder 10.7 CNR1 HTR7 PDYN
30 uremic pruritus 10.7 CNR1 OPRK1
31 female reproductive system disease 10.6 OXT POMC TRPV1
32 anismus 10.6 OXT TAC1
33 eating disorder 10.6 CCK CNR1 POMC
34 separation anxiety disorder 10.6 HTR7 OPRM1 OXT
35 nasal cavity adenocarcinoma 10.6 CCK PDYN
36 premenstrual tension 10.6 LIPN OXT POMC
37 endogenous depression 10.6 HTR7 OXT POMC
38 diverticulitis of colon 10.6 CNR1 TRPV1
39 mental depression 10.6 HTR7 OXT POMC
40 aspiration pneumonia 10.5 TAC1 TRPV1
41 cocaine dependence 10.5 OPRK1 OPRM1 PDYN POMC
42 irritable bowel syndrome 10.5 CCK HTR7 TAC1 TRPV1
43 substance dependence 10.5 CNR1 OPRK1 OPRM1 POMC
44 migraine with or without aura 1 10.5 CNR1 HTR7 TAC1 TRPV1
45 anorexia nervosa 10.4 CCK OXT POMC
46 cutaneous solitary mastocytoma 10.4 PDYN POMC
47 withdrawal disorder 10.3 CNR1 HTR7 OPRM1 PDYN POMC
48 trigeminal nerve disease 10.2 TAC1 TRPV1
49 epidural abscess 10.1
50 horner's syndrome 10.1

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1
2 homeostasis/metabolism MP:0005376 9.93 LIPN OPRK1 OPRL1 OPRM1 OXT PDYN
3 adipose tissue MP:0005375 9.8 CNR1 OPRM1 OXT PDYN POMC TRPV1
4 integument MP:0010771 9.7 CNR1 HTR7 OPRK1 OPRL1 OPRM1 OXT
5 nervous system MP:0003631 9.32 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 687)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 437-38-7 3345
3
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27262-47-1 92253
4
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 84057-95-4 71273 175805
5
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 6740-88-1 3821
6
Nalbuphine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 20594-83-6 5360630 5311304
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
8
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 27203-92-5 33741
9
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 74103-06-3, 66635-83-4 3826
10
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
11 Nefopam Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 13669-70-0
12
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
13
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 4205-90-7 2803
14
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 56030-54-7 41693
15
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
16
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
17
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
18
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
19
Dezocine Approved, Investigational Phase 4,Not Applicable 53648-55-8 40841 3033053
20
Flurbiprofen Approved, Investigational Phase 4,Not Applicable 5104-49-4 3394
21
Palonosetron Approved, Investigational Phase 4,Not Applicable 135729-61-2, 119904-90-4, 135729-56-5 148211
22
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
23
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
24
Cisatracurium Approved Phase 4,Not Applicable,Early Phase 1 96946-41-7
25
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
26
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 2078-54-8 4943
27
Remifentanil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 132875-61-7 60815
28
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
29
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
30
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 28523-86-6 5206
31
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7487-88-9 24083
32
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 60142-96-3 3446
33
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 113775-47-6 68602 5311068
34
Benzoic Acid Approved, Investigational Phase 4 65-85-0 243
35
Mineral oil Approved, Vet_approved Phase 4,Phase 3 8042-47-5
36
Prilocaine Approved Phase 4,Phase 2,Phase 3,Not Applicable 721-50-6 4906
37
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
38
Codeine Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 76-57-3 5284371
39
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
40
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 22204-53-1 1302 156391
41
Chloroprocaine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 133-16-4 8612
42
Procaine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 59-46-1 4914
43
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
44
Droperidol Approved, Vet_approved Phase 4,Phase 3,Not Applicable 548-73-2 3168
45
Meperidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 57-42-1 4058
46
Ethyl chloride Approved, Experimental, Investigational Phase 4,Early Phase 1 75-00-3
47
Tetracaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 94-24-6 5411
48
Terbutaline Approved Phase 4 23031-25-6 5403
49
Alfentanil Approved, Illicit Phase 4,Not Applicable 71195-58-9 51263
50
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Not Applicable 147-24-0, 58-73-1 3100

Interventional clinical trials:

(show top 50) (show all 3786)
# Name Status NCT ID Phase Drugs
1 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
2 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
3 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
4 Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
5 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
6 Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
7 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
8 Analgesia After Total Knee Arthroplasty Unknown status NCT00869037 Phase 4 Periarticular Injection;CFNB + Posterior Capsular Injection
9 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
10 The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery Unknown status NCT02503826 Phase 4 Sufentanil;Sufentanil;Sufentanil;Midazolam;propofol;cisatracurium
11 Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT01465191 Phase 4 Morphine
12 Dexamethasone or Clonidine as Adjuncts to Ropivacaine for Caudal Analgesia on Analgesia Duration in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
13 Postoperative Analgesia by Epidural vs IV Ketamine Concurrent With Caudal Anesthesia in Pediatric Orthopedic Surgery Unknown status NCT00532662 Phase 4 S(+)-ketamine
14 Patient Re-education vs. Background Morphine to IV-PCA in Patient With Unsatisfactory Analgesia Post Laparotomy Unknown status NCT02523846 Phase 4 morphine
15 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
16 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
17 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
18 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine
19 Home Infusors for Analgesia After Foot Surgery Unknown status NCT00600899 Phase 4
20 Continuous Wound Catheter Analgesia Associated With Intravenous Morphine PCA After Thoracotomy Unknown status NCT01698203 Phase 4 ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun);Placebo;ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
21 the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation Unknown status NCT02635802 Phase 4 Remifentanil;Lidocaine;Remifentanil+Lidocaine;Midazolam
22 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
23 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
24 The Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic for Total Hip Replacement Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
25 A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery Unknown status NCT00244283 Phase 4 Sevoflurane
26 Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy Unknown status NCT01542697 Phase 4 intraperitoneal nebulisation of magnesium sulphate
27 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
28 Minimum Effective Dose (MED) & Epidural Bupivacaine Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
29 Quadratus Lumborum Block for Postoperative Analgesia After Colostomy Closure Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
30 Fast-release Orodispersible Tramadol as Analgesia in Termination of Pregnancy by Vacuum Aspiration. Unknown status NCT02416141 Phase 4 fast release oro dispersible tramadol 50 mg
31 Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery Unknown status NCT02576223 Phase 4 Ropivacaine hydrochloride;Isotonic Saline
32 Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery Unknown status NCT02672813 Phase 4
33 Obturator and Femoral Nerve Block in Patients With Hip Fracture Unknown status NCT02540837 Phase 4 Bupivacaine;Saline
34 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
35 Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically Unknown status NCT02355093 Phase 4 ropivacaine
36 A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section Unknown status NCT02741219 Phase 4 Normal saline;Dexmedetomidine;Sufentanil;Sufentanil and dexmedetomidine
37 Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice Unknown status NCT01303614 Phase 4 Lidocaine-Prilocaine cream;placebo
38 Perioperative Analgesia After Knee Arthroplasty Unknown status NCT01225484 Phase 4
39 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
40 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
41 Dexamethasone and Block Duration in Upper Extremity Unknown status NCT01756573 Phase 4 Dexamthsone;Bupivacaine
42 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
43 Transversus Abdominis Plane Block (TAP) for Laparoscopic Cholecystectomy Surgery Unknown status NCT02185716 Phase 4 Levobupivacaine 0.25 %;Levobupivacaine 0.5%
44 Effect of Dexamethasone on Duration of Lower Extremity Blocks With Bupivacaine in Subjects Having ACL Repair Unknown status NCT01756560 Phase 4 dexamethsone;Bupivacaine
45 Analgesic Efficacy of Intravenous Hyoscine-N-Butylbromide (HNB) in Abdominal Colic Associated With Acute Gastroenteritis Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
46 Study of the Use of Humidified Warmed Gas and the Effect on Post-Operative Pain in Laparoscopic Cholecystectomies Unknown status NCT00792389 Phase 4
47 Postoperative Analgesia in Laminectomy Unknown status NCT02255955 Phase 4 550 mg naproxen sodium and 30mg codeine;300 mg paracetamol and 30 mg codeine;placebo tablet
48 Determination of the Minimum Local Analgesic Dose of Spinal Chloroprocaine in Labour Unknown status NCT01909089 Phase 4 Spinal administration of chloroprocaine.
49 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
50 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

41
Liver, Colon, Brain, Bone, Lung, Heart, Skin

Publications for Pain Agnosia

Articles related to Pain Agnosia:

# Title Authors Year
1
Pain agnosia and self-injury in the syndrome of reversible somatotropin deficiency (psychosocial dwarfism). ( 5068666 )
1972

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.98 CNR1 HTR7 OPRK1 OPRL1 OPRM1 PSENEN
2 axon GO:0030424 9.76 CCK CNR1 OPRM1 TAC1
3 neuronal cell body GO:0043025 9.63 CCK OPRK1 PDYN PNOC TAC1 TRPV1
4 perikaryon GO:0043204 9.56 CCK NPFF OPRK1 OPRM1
5 terminal bouton GO:0043195 9.5 AP2M1 CCK OXT
6 clathrin adaptor complex GO:0030131 9.37 AP1M2 AP2M1
7 axon terminus GO:0043679 9.26 NPFF OPRK1 PDYN PNOC
8 dendrite GO:0030425 9.23 CCK HTR7 NPFF OPRK1 OPRM1 PDYN
9 plasma membrane GO:0005886 10.18 AP2M1 CNR1 HTR7 OPRK1 OPRL1 OPRM1

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.96 CCK CNR1 PSENEN TRPV1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.91 NPFF OPRL1 OXT TAC1 TRPV1
3 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.85 CNR1 HTR7 OPRK1 OPRL1 OPRM1
4 response to morphine GO:0043278 9.83 CNR1 NPFF OPRK1 OPRM1 TAC1
5 response to ethanol GO:0045471 9.82 CNR1 OPRK1 OPRM1
6 excitatory postsynaptic potential GO:0060079 9.8 NPFF OPRM1 TRPV1
7 response to cocaine GO:0042220 9.78 CNR1 OPRK1 OPRM1 OXT
8 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.77 OPRK1 OPRL1 OPRM1
9 eating behavior GO:0042755 9.77 CCK OPRK1 OPRL1 OPRM1 OXT
10 negative regulation of blood pressure GO:0045776 9.76 CNR1 OPRL1 OXT
11 sensory perception of pain GO:0019233 9.73 CNR1 OPRK1 OPRL1 OPRM1 TAC1 TRPV1
12 positive regulation of blood pressure GO:0045777 9.71 CNR1 NPFF OXT
13 estrous cycle GO:0044849 9.7 OPRK1 OPRL1 OPRM1
14 opioid receptor signaling pathway GO:0038003 9.67 OPRK1 OPRL1 OPRM1
15 maternal process involved in female pregnancy GO:0060135 9.66 CNR1 NPFF
16 response to food GO:0032094 9.65 OPRM1 OXT
17 response to pain GO:0048265 9.65 TAC1 TRPV1
18 positive regulation of ossification GO:0045778 9.64 OXT TAC1
19 positive regulation of renal sodium excretion GO:0035815 9.64 OXT TAC1
20 maternal behavior GO:0042711 9.63 OPRK1 OXT
21 negative regulation of heart rate GO:0010459 9.63 NPFF TAC1
22 negative regulation of appetite GO:0032099 9.62 CCK NPFF
23 behavior GO:0007610 9.61 OPRK1 OPRL1
24 acute inflammatory response to antigenic stimulus GO:0002438 9.61 NPFF OPRM1
25 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0106072 9.59 OPRL1 OPRM1
26 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.57 OPRK1 OPRM1
27 positive regulation of gastric acid secretion GO:0060454 9.56 OPRL1 TRPV1
28 sensory perception GO:0007600 9.55 OPRK1 OPRL1 OPRM1 PDYN PNOC
29 regulation of sensory perception of pain GO:0051930 9.43 CCK NPFF OPRK1 OPRL1 OPRM1 OXT
30 neuropeptide signaling pathway GO:0007218 9.23 NPFF OPRK1 OPRL1 OPRM1 PDYN PNOC
31 signal transduction GO:0007165 10.27 CCK CNR1 HTR7 OPRK1 OPRL1 OPRM1
32 G-protein coupled receptor signaling pathway GO:0007186 10.1 CCK CNR1 HTR7 NPFF OPRK1 OPRL1
33 regulation of signaling receptor activity GO:0010469 10.02 CCK NPFF OXT PDYN PNOC POMC
34 chemical synaptic transmission GO:0007268 10.01 HTR7 NPFF OPRK1 OPRL1 OPRM1 PDYN

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.58 CCK OXT POMC
2 peptide binding GO:0042277 9.54 OPRK1 OPRL1 OPRM1
3 neuropeptide binding GO:0042923 9.33 OPRK1 OPRL1 OPRM1
4 opioid peptide activity GO:0001515 9.32 PDYN PNOC
5 opioid receptor binding GO:0031628 9.26 PDYN PNOC
6 opioid receptor activity GO:0004985 9.13 OPRK1 OPRL1 OPRM1
7 neuropeptide hormone activity GO:0005184 9.1 CCK NPFF OXT PDYN PNOC POMC

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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