Pain Agnosia

Categories: Mental diseases

Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 15 17
Analgesia 12 15


External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to chronic pain and ileus. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Tenoxicam and Orange have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 868)
# Related Disease Score Top Affiliating Genes
1 chronic pain 32.2 OPRM1 CNR1
2 ileus 31.8 POMC OPRM1 CCK
3 amnestic disorder 31.4 PDYN OPRM1 OPRK1 OPRD1 HTR3A CNR1
4 constipation 31.0 TAC1 PDYN OPRM1 OPRL1 OPRK1 OPRD1
5 opioid addiction 31.0 PNOC OPRM1 OPRK1 OPRD1 CCK
6 fibromyalgia 31.0 POMC PNOC OPRM1 OPRK1 OPRD1 HTR3A
7 diabetic neuropathy 31.0 TRPV1 OPRD1 CNR1
8 opiate dependence 31.0 POMC PDYN OPRM1 OPRL1 OPRK1 OPRD1
9 arachnoiditis 30.9 TAC1 RPL34 POMC
10 trigeminal neuralgia 30.8 TRPV1 TAC1 OPRM1 OPRL1 OPRK1 OPRD1
11 leptin deficiency or dysfunction 30.8 POMC NPS CCK
12 mononeuropathy 30.8 TRPV1 TAC1 RPL34
13 reflex sympathetic dystrophy 30.7 TAC1 NPS
14 withdrawal disorder 30.7 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
15 irritable bowel syndrome 30.7 TRPV1 TAC1 POMC OPRM1 HTR3A CNR1
16 motion sickness 30.7 TAC1 POMC OPRM1 HTR3A CNR1
17 morphine dependence 30.7 PDYN OXT OPRM1 OPRL1 OPRK1 OPRD1
18 substance abuse 30.7 PDYN OPRM1 OPRL1 OPRK1 OPRD1 CNR1
19 paralytic ileus 30.7 TCF21 OPRM1 OPRL1 OPRK1 OPRD1 HTR3A
20 post-traumatic stress disorder 30.7 POMC FAAH CNR1
21 peripheral nervous system disease 30.6 TRPV1 TAC1 RPL34 POMC OPRM1 NPS
22 bone cancer 30.6 TRPV1 PDYN CNR1
23 cannabis abuse 30.5 OPRM1 FAAH CNR1
24 opioid abuse 30.5 PNOC PDYN OPRM1 OPRL1 OPRK1 OPRD1
25 diarrhea 30.4 TAC1 POMC OPRM1 OPRK1 HTR3A CCK
26 tobacco addiction 30.4 PDYN OPRM1 CNR1
27 uremic pruritus 30.3 OPRK1 CNR1
28 drug dependence 30.3 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
29 burning mouth syndrome 30.3 TRPV1 TAC1 CNR1
30 causalgia 30.2 TAC1 NPS
31 retrograde amnesia 30.2 POMC PDYN
32 endogenous depression 30.2 POMC OXT HTR3A
33 myofascial pain syndrome 30.2 TRPV1 TAC1 POMC NPS
34 neonatal abstinence syndrome 30.2 PNOC OPRM1 OPRL1 OPRK1 OPRD1
35 polyradiculopathy 30.2 TRPV1 TAC1 RPL34 NPS
36 supine hypotensive syndrome 30.2 RPL34 OXT
37 migraine with or without aura 1 30.1 TRPV1 TAC1 POMC PNOC OXT OPRM1
38 mental depression 30.1 POMC OXT NPS HTR3A
39 body mass index quantitative trait locus 11 30.1 TRPV1 POMC OXT NPS FAAH CNR1
40 anxiety 30.1 TAC1 POMC PNOC PDYN OXT OPRM1
41 hypochondriasis 30.1 POMC HTR3A
42 panic disorder 30.0 TAC1 POMC OPRL1 HTR3A CCK
43 obsessive-compulsive disorder 30.0 POMC PDYN OXT HTR3A CCK
44 alcohol dependence 30.0 POMC PNOC PDYN OXT OPRM1 OPRL1
45 paine syndrome 29.9 TRPV1 TAC1 PNOC OPRM1 OPRL1 OPRD1
46 schizophrenia 29.7 POMC PDYN OXT OPRM1 HTR3A FAAH
47 agnosia 29.1 TRPV1 TRAPPC9 TCF21 TAC1 RPL34 POMC
48 increased analgesia from kappa-opioid receptor agonist, female-specific 12.5
49 obsolete: chronic pain requiring intraspinal analgesia 12.2
50 indifference to pain, congenital, autosomal recessive 11.6

Graphical network of the top 20 diseases related to Pain Agnosia:

Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CNR1 FAAH HTR3A NPFF OPRD1 OPRK1
2 homeostasis/metabolism MP:0005376 10.17 CCK CNR1 FAAH HTR3A LIPN OPRD1
3 integument MP:0010771 10.1 CNR1 FAAH HTR3A OPRD1 OPRK1 OPRL1
4 nervous system MP:0003631 9.97 CCK CNR1 FAAH HTR3A OPRD1 OPRK1
5 no phenotypic analysis MP:0003012 9.5 CCK CNR1 OPRD1 OPRM1 PDYN POMC
6 renal/urinary system MP:0005367 9.23 CCK HTR3A OXT POMC TAC1 TCF21

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 634)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Tenoxicam Approved Phase 4 59804-37-4 5312154
2 Orange Approved Phase 4
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Fosaprepitant Approved Phase 4 172673-20-0 219090
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
Butorphanol Approved, Illicit, Vet_approved Phase 4 42408-82-2, 58786-99-5 5361092
Lactulose Approved Phase 4 4618-18-2 11333
Nicotine Approved Phase 4 54-11-5 942 89594
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
Tapentadol Approved Phase 4 175591-23-8 9838022
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
Ziconotide Approved Phase 4 107452-89-1 447451
Dimenhydrinate Approved Phase 4 523-87-5 441281
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
Methylnaltrexone Approved Phase 4 916055-93-1, 83387-25-1 6603824
Etomidate Approved Phase 4 33125-97-2 36339 667484
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
Dolasetron Approved, Investigational Phase 4 115956-12-2 60654
Loperamide Approved Phase 4 53179-11-6 3955
Dalteparin Approved Phase 4 9005-49-6
Belladonna Approved, Experimental Phase 4
Glycerol Approved, Investigational Phase 4 56-81-5 753
Flavoxate Approved Phase 4 15301-69-6 3354
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035

Interventional clinical trials:

(show top 50) (show all 5338)
# Name Status NCT ID Phase Drugs
1 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
2 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
3 Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy Unknown status NCT03288428 Phase 4 Nalbuphine;Morphine
4 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
5 A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
6 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
7 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
8 Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial. Unknown status NCT03018171 Phase 4 Clonidine;Sufentanil
9 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
10 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
11 Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. Unknown status NCT00532662 Phase 4 S(+)-ketamine
12 Comparison of Three Different Rates of Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Coblation Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
13 The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks Following Oromaxillofacial Reconstruction Unknown status NCT03118076 Phase 4 0.3% ropivacaine and 50 μg dexmedetomidine;Ropivacaine
14 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
15 A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section Unknown status NCT02741219 Phase 4 Normal saline;Dexmedetomidine;Sufentanil;Sufentanil and dexmedetomidine
16 Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study Unknown status NCT02733835 Phase 4 Remifentanil
17 Postoperative Analgesia After Thoracotomy Without Thoracic Epidural Analgesia: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine Patient-Controlled-Analgesia (PCA) Unknown status NCT01698203 Phase 4 ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun);Placebo;ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
18 Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery Unknown status NCT03014713 Phase 4 Dezocine;Flubiprofen;Dexmedetomidine
19 Comparison of the ED95 Dose of 0.075% and 0.1% Bupivacaine for Labour Analgesia in Primigravida. Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
20 Transversus Abdominis Plane Blocks in Patients Scheduled for an Abdominoplasty. A Prospective, Randomized, Double Blind, Comparison Between the Posterior Approach and Placebo. Unknown status NCT01278264 Phase 4 Ropivacaine 0.25%, 0.5 ml/kg;Ropivacaine 0.25%, 0.5 ml/kg
21 Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients Unknown status NCT02909322 Phase 4
22 Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy Unknown status NCT02523846 Phase 4 morphine
23 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
24 Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery. Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
25 The Efficacy and the Safety of Dexmedetomidine Sedation on the PICU Patients-A Randomized, Controlled Study. Unknown status NCT02296073 Phase 4 Midazolam;Dexmedetomidine;Dexmedetomidine;Dexmedetomidine;Fentanyl
26 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
27 Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial Unknown status NCT02680626 Phase 4 Magnesium Sulfate;Ropivacaine
28 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
29 Comparison of the Analgesic Efficacy of Continuous Femoral Nerve Block and Adductor Canal Block With Steroid Adjuvant in Patients Undergoing Total Knee Arthroplasty Unknown status NCT01973530 Phase 4
30 The Comparison of 0.15 Milligram Spinal Morphine Treatment for Morphine Requirement After Video-assisted Thoracoscopic Surgery. A Pilot Randomized Control Study Unknown status NCT01979354 Phase 4 Spinal morphine
31 Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
32 Study Protocol "OFA: Opioid-Free Anesthesia". Unknown status NCT03124082 Phase 4 Remifentanil;Ketamine;Lidocaine;Clonidine
33 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
34 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
35 A Randomized Controlled Trial Comparing Combined Spinal- Epidural Dosing Strategies for External Cephalic Version Unknown status NCT01991743 Phase 4 Group 2.5;Group 5;Group 7.5;Group 10
36 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
37 Use of Home Pumps for Analgesia After Ambulatory Foot Surgery - Comparison of Two Infusion Rates - a Randomized, Double-Blind Study Unknown status NCT00600899 Phase 4
38 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
39 Tablet vs. Liquid Suspension Ibuprofen in the Relief of Pain Unknown status NCT01681667 Phase 4 Ibuprofen
40 Postoperative Analgesia in Total Hip Replacement: a Comparison of the Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic With Intrathecal Morphine. Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
41 Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction Unknown status NCT02923128 Phase 4 Dexmedetomidine;Sufentanyl;Saline
42 Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on the Patients That is Undergoing Abdominal Hysterectomy Unknown status NCT02092012 Phase 4 dexketoprofen trometamol;Dexmedetomidine
43 Efficacy of Regional Analgesia Techniques (Quadratus Lumborum Block and Transversus Abdominis Plane Block) in Acute and Chronic Pain Treatment in Patients After Cesarean Delivery Unknown status NCT03244540 Phase 4 Ropivacaine;Paracetamol;Metamizol;Ketoprofen;Bupivacaine
44 Does Preemptive Epidural Morphine Prevent Remifentanil Induced Hyperalgesia Unknown status NCT03225690 Phase 4 Morphine;Serum physiologic
45 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
46 Intraoperative Use of Dexketoprofen Trometamol, Tramadol Hcl, Pethidine Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication Unknown status NCT01558622 Phase 4 dexketoprofen trometamol;tramadol hydrochloride;pethidine hydrochloride;dexketoprofen trometamol + tramadol hydrochloride;dexketoprofen trometamol + pethidine hydrochloride;vitamin c
47 Phase IV Recruiting Unknown status NCT01542697 Phase 4 intraperitoneal nebulisation of magnesium sulphate
48 Randomised Controlled Trail of Warmed Humidified Insufflation Versus Cold Non-Humidified Insufflation in Elective Laparoscopic Cholecystectomies: Does This Reduce Post-Operative Pain? Unknown status NCT00792389 Phase 4
49 Postoperative Pain Management After Minimally Invasive Esophagectomy Unknown status NCT02042313 Phase 4

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

Breast, Brain, Testes, Heart, Liver, Lung, Colon

Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30002)
# Title Authors PMID Year
Pericapsular nerve group (PENG) block for postoperative analgesia after open reduction of pediatric congenital dysplasia of the hip. 61
31796372 2020
Cost-effective multimodal analgesia in the perioperative period: Use of intravenous vs. oral acetaminophen. 61
31676119 2020
Labor epidural analgesia and the risk of postpartum depression: A meta-analysis of observational studies. 61
31784304 2020
Sacral erector spinae plane block provides effective postoperative analgesia for pelvic and sacral fracture surgery. 61
31812367 2020
Erector spinae plane block for postoperative analgesia in kidney transplantation: A report of 3 cases. 61
31822436 2020
Oral multimodal preemptive analgesia improves postoperative pain control and decreases opioid utilization in spinal fusion patients. 61
31822438 2020
Suprascapular nerve block versus interscalene block for analgesia after arthroscopic rotator cuff repair. 61
32021031 2020
Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial. 61
31761417 2020
Ultrasound-guided bilateral superficial cervical plexus blocks enhance the quality of recovery in patients undergoing thyroid cancer surgery: A randomized controlled trial. 61
31761416 2020
Utilization of prescription opioid analgesia after oculoplastic surgery. 61
31169424 2020
Enhanced Recovery After Surgery (ERAS): A Perspective Review of Postoperative Pain Management Under ERAS Pathways and Its Role on Opioid Crisis in the United States. 61
31868759 2020
Reply to: Ultrasound-guided erector spinae plane block versus oblique subcostal transversus abdominis plane block for postoperative analgesia of adult patients undergoing laparoscopic cholecystectomy: Randomized controlled trial. 61
31437596 2020
Current Trends in Anesthesia Management in Hallux Valgus. 61
31997746 2020
Functional recovery after knee arthroplasty with regional analgesia. 61
32028293 2020
Reply to: functional recovery after knee arthroplasty with regional analgesia. 61
32028294 2020
Ultrasound-guided inferior alveolar nerve block for postoperative analgesia after mandibular sequestrectomy: A single-center retrospective study. 61
31442855 2020
Pectoralis-Intercostal-Rectus Sheath (PIRS) Plane Block With Catheters. A New Technique to Provide Analgesia in Cardiac Surgery. 61
31590939 2020
Citral-induced analgesia is associated with increased spinal serotonin, reduced spinal nociceptive signaling, and reduced systemic oxidative stress in arthritis. 61
31846747 2020
Adherence to non-opioid multimodal analgesia (NOMA) protocol is associated with a shorter length of stay after thoracic surgery. 61
31634765 2020
The safety and efficacy of hydromorphone via patient controlled analgesia or patient controlled analgesia by proxy for pediatric postoperative pain control. 61
31466034 2020
Should erector spinae plane block be routinely used for postoperative analgesia? 61
31437591 2020
Ultrasound guided sacral erector spinae block for postoperative analgesia in pediatric anoplasty surgeries. 61
31491727 2020
Intraoperative Ketamine for Analgesia Post-Coronary Artery Bypass Surgery: A Randomized, Controlled, Double-Blind Clinical Trial. 61
31708422 2020
Single level bilateral ESPB provides effective analgesia for both lower and upper laparoscopic abdominal surgeries. 61
31454635 2020
Kidney stones and the opioid epidemic: recent developments and review of the literature. 61
31834080 2020
Medical Expulsive Therapy (Alpha Blockers) for Urological Stone Disease. 61
32034826 2020
Regional Anesthesia in Cardiac Surgery: An Overview of Fascial Plane Chest Wall Blocks. 61
32032103 2020
Preemptive Analgesic Efficacy of the Ultrasound-Guided Bilateral Superficial Serratus Plane Block on Postoperative Pain in Breast Reduction Surgery: A Prospective Randomized Controlled Study. 61
31741068 2020
Brachial Plexus Block with Liposomal Bupivacaine for Shoulder Surgery Improves Analgesia and Reduces Opioid Consumption: Results from a Multicenter, Randomized, Double-Blind, Controlled Trial. 61
31150095 2020
Efficacy of an Ultrasound-Guided Erector Spinae Plane Block for Postoperative Analgesia Management After Video-Assisted Thoracic Surgery: A Prospective Randomized Study. 61
31122843 2020
Prolonged-Release (PR) Oxycodone/Naloxone Improves Bowel Function Compared with Oxycodone PR and Provides Effective Analgesia in Chinese Patients with Non-malignant Pain: A Randomized, Double-Blind Trial. 61
32020565 2020
Comparison of Programmed Intermittent Epidural Boluses With Continuous Epidural Infusion for the Maintenance of Labor Analgesia: A Randomized, Controlled, Double-Blind Study. 61
30882524 2020
Ultrasound-guided superficial cervical plexus block for analgesia in patients undergoing craniotomy via suboccipital retrosigmoid approach: study protocol of a randomised controlled trial. 61
32029493 2020
An investigation of the effect of patient-controlled analgesia on long-term quality of life after major surgery: A prospective cohort study. 61
31868859 2020
Comparative evaluation of epidural bupivacaine alone and bupivacaine combined with magnesium sulfate in providing postoperative analgesia: a meta-analysis of randomized controlled trials. 61
32024465 2020
Infrared thermography to assess dermatomal levels of labor epidural analgesia with 1 mg/mL ropivacaine plus 0.5 µg/mL sufentanil: a prospective cohort study. 61
31522934 2020
Adverse side effects and route of administration of opioids in combined spinal-epidural analgesia for labour: a meta-analysis of randomised trials. 61
31704251 2020
A Pilot Randomized Controlled Trial of Outcomes Associated with Parent-Nurse Controlled Analgesia vs. Continuous Opioid Infusion in the Neonatal Intensive Care Unit. 61
31494028 2020
The effect of preemptive use of pregabalin on postoperative morphine consumption and analgesia levels after laparoscopic colorectal surgery: a controlled randomized trial. 61
31863206 2020
Opioid prescribing practices in a pediatric burn tertiary care facility: Is it time to change? 61
31862279 2020
Opioid free postoperatively using Pecto-Intercostal Fascial Block (PIFB) with multimodal Analgesia (MMA) in a patient with myasthenia gravis underwent thymectomy via sternotomy. 61
31200189 2020
Fascial plane blocks in thoracic surgery: a new era or plain painful? 61
31688087 2020
Interventional anesthesia and palliative care collaboration to manage cancer pain: a narrative review. 61
31571119 2020
The Ever-Changing Paradigm of Postoperative Analgesia: Commentary on an article by Tetsu Ohnuma, MD, MPH, et al.: "Dose-Dependent Association of Gabapentinoids with Pulmonary Complications After Total Hip and Knee Arthroplasties". 61
32022761 2020
The effect of ultrasound-guided intercostal nerve block, single-injection erector spinae plane block and multiple-injection paravertebral block on postoperative analgesia in thoracoscopic surgery: A randomized, double-blinded, clinical trial. 61
31330457 2020
Music therapy to optimise postoperative pain management: how much more evidence is needed? 61
32034970 2020
Concerned topics of epidural labor analgesia: labor elongation and maternal pyrexia: a systematic review. 61
32032081 2020
Bitter Gold Analgesia: Grover Cleveland's Remedy. 61
31939840 2020
[Analgesia for trauma patients in emergency medicine]. 61
32002561 2020
Failure of Placebo Analgesia Model in Rats with Inflammatory Pain. 61
31435837 2020

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.06 TAC1 POMC PNOC PDYN OXT NPS
2 integral component of plasma membrane GO:0005887 9.98 TRPV1 OPRM1 OPRL1 OPRK1 OPRD1 HTR3A
3 axon GO:0030424 9.77 TAC1 OPRM1 HTR3A CNR1 CCK
4 dendrite GO:0030425 9.73 TRPV1 PNOC PDYN OPRM1 NPFF CCK
5 neuronal cell body GO:0043025 9.63 TRPV1 TAC1 PNOC PDYN HTR3A CCK
6 spine apparatus GO:0097444 9.32 OPRM1 OPRD1
7 integral component of presynaptic membrane GO:0099056 9.26 OPRM1 OPRD1 HTR3A CNR1
8 axon terminus GO:0043679 8.92 PNOC PDYN OPRD1 NPFF

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.24 POMC PNOC OXT OPRM1 OPRL1 OPRK1
2 G protein-coupled receptor signaling pathway GO:0007186 9.97 TAC1 POMC PNOC PDYN OXT OPRM1
3 chemical synaptic transmission GO:0007268 9.93 TAC1 PNOC PDYN OPRK1 NPFF HTR3A
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 TRPV1 TAC1 OXT NPFF
5 response to ethanol GO:0045471 9.84 OPRM1 HTR3A CNR1
6 excitatory postsynaptic potential GO:0060079 9.83 TRPV1 OPRM1 NPFF HTR3A
7 memory GO:0007613 9.82 OXT CNR1 CCK
8 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.81 OPRM1 OPRL1 OPRK1 OPRD1
9 cellular response to growth factor stimulus GO:0071363 9.8 TRPV1 OPRD1 HTR3A
10 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.79 OPRM1 OPRD1 CNR1
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.79 OPRM1 OPRK1 OPRD1
12 response to cocaine GO:0042220 9.78 OXT OPRM1 HTR3A CNR1
13 negative regulation of blood pressure GO:0045776 9.75 OXT OPRL1 CNR1
14 response to morphine GO:0043278 9.73 TAC1 OPRM1 NPFF CNR1
15 sensory perception of pain GO:0019233 9.73 TRPV1 TAC1 OPRM1 OPRL1 OPRK1 CNR1
16 positive regulation of blood pressure GO:0045777 9.72 OXT NPFF CNR1
17 eating behavior GO:0042755 9.72 OXT OPRM1 OPRL1 OPRD1 CCK
18 opioid receptor signaling pathway GO:0038003 9.71 OPRM1 OPRL1 OPRK1 OPRD1
19 response to food GO:0032094 9.67 OXT OPRM1
20 response to pain GO:0048265 9.67 TRPV1 TAC1
21 negative regulation of heart rate GO:0010459 9.67 TRPV1 TAC1 NPFF
22 sensory perception GO:0007600 9.67 PNOC OPRM1 OPRL1 OPRK1
23 estrous cycle GO:0044849 9.66 OPRM1 OPRL1
24 positive regulation of ossification GO:0045778 9.65 TAC1 OXT
25 positive regulation of renal sodium excretion GO:0035815 9.65 TAC1 OXT
26 positive regulation of synaptic transmission, GABAergic GO:0032230 9.64 TAC1 NPS
27 behavior GO:0007610 9.64 OPRL1 OPRK1
28 negative regulation of appetite GO:0032099 9.63 NPFF CCK
29 acute inflammatory response to antigenic stimulus GO:0002438 9.62 OPRM1 NPFF
30 positive regulation of sensory perception of pain GO:1904058 9.61 OPRL1 CCK
31 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.6 OPRM1 OPRL1
32 positive regulation of action potential GO:0045760 9.59 TAC1 NPS
33 positive regulation of gastric acid secretion GO:0060454 9.57 TRPV1 OPRL1
34 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.56 OPRM1 OPRK1
35 regulation of sensory perception of pain GO:0051930 9.43 OXT OPRM1 OPRL1 OPRD1 NPFF CCK
36 neuropeptide signaling pathway GO:0007218 9.32 TAC1 POMC PNOC PDYN OPRM1 OPRL1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.58 POMC OXT CCK
2 peptide binding GO:0042277 9.56 OPRM1 OPRL1 OPRK1 OPRD1
3 neuropeptide hormone activity GO:0005184 9.46 PNOC OXT NPFF CCK
4 opioid receptor binding GO:0031628 9.37 PNOC PDYN
5 opioid peptide activity GO:0001515 9.32 PNOC PDYN
6 neuropeptide binding GO:0042923 9.26 OPRM1 OPRL1 OPRK1 OPRD1
7 opioid receptor activity GO:0004985 8.92 OPRM1 OPRL1 OPRK1 OPRD1

Sources for Pain Agnosia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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