MCID: PNG002
MIFTS: 51

Pain Agnosia

Categories: Mental diseases

Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 15 17
Analgesia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to amnestic disorder and postpartum depression. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Nalbuphine and Tenoxicam have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 881)
# Related Disease Score Top Affiliating Genes
1 amnestic disorder 31.4 PDYN OPRM1 OPRK1 OPRD1 HTR3A CNR1
2 postpartum depression 31.3 POMC PNOC OXT
3 opioid addiction 31.1 PNOC OPRM1 OPRK1 OPRD1
4 constipation 31.0 TRPV1 TAC1 PDYN OPRM1 OPRL1 OPRK1
5 fibromyalgia 31.0 POMC PNOC OPRM1 OPRK1 OPRD1 HTR3A
6 diabetic neuropathy 31.0 TRPV1 OPRD1 CNR1
7 opiate dependence 30.9 POMC PDYN OPRM1 OPRL1 OPRK1 OPRD1
8 trigeminal neuralgia 30.9 TRPV1 TAC1 OPRM1 OPRL1 OPRK1 OPRD1
9 paralytic ileus 30.9 TCF21 TAC1 OPRM1 HTR3A
10 arachnoiditis 30.9 TAC1 RPL34 POMC
11 mononeuropathy 30.8 TRPV1 TAC1 RPL34
12 morphine dependence 30.8 PDYN OXT OPRM1 OPRL1 OPRK1 OPRD1
13 irritable bowel syndrome 30.8 TRPV1 TAC1 POMC OPRM1 HTR3A CNR1
14 reflex sympathetic dystrophy 30.8 TAC1 NPS ADRA2C ADRA2B
15 algoneurodystrophy 30.7 TAC1 NPS
16 prostatic adenoma 30.7 ADRA2C ADRA2B ADRA2A
17 peripheral nervous system disease 30.7 TRPV1 TAC1 RPL34 POMC OPRM1 NPS
18 post-traumatic stress disorder 30.7 POMC FAAH CNR1
19 withdrawal disorder 30.7 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
20 opioid abuse 30.6 PNOC PDYN OPRM1 OPRL1 OPRK1 OPRD1
21 substance abuse 30.6 POMC PDYN OPRM1 OPRL1 OPRK1 OPRD1
22 motion sickness 30.6 TAC1 POMC OPRM1 HTR3A CNR1 ADRA2A
23 cannabis abuse 30.5 OPRM1 FAAH CNR1
24 diarrhea 30.4 TRPV1 TAC1 POMC OPRM1 OPRK1 OPRD1
25 prostatic hypertrophy 30.4 ADRA2C ADRA2B ADRA2A
26 anxiety 30.4 TAC1 POMC PNOC PDYN OXT OPRM1
27 uremic pruritus 30.3 OPRK1 CNR1
28 drug dependence 30.3 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
29 orthostatic intolerance 30.3 POMC ADRA2C ADRA2B ADRA2A
30 tobacco addiction 30.3 PDYN OPRM1 CNR1
31 hypochondriasis 30.3 POMC HTR3A
32 burning mouth syndrome 30.3 TRPV1 TAC1 CNR1
33 migraine with or without aura 1 30.3 TRPV1 TAC1 POMC PNOC PDYN OXT
34 myofascial pain syndrome 30.2 TRPV1 TAC1 POMC NPS
35 retrograde amnesia 30.2 POMC PDYN
36 polyradiculopathy 30.2 TRPV1 TAC1 RPL34 NPS
37 endogenous depression 30.2 POMC OXT HTR3A
38 body mass index quantitative trait locus 11 30.2 TRPV1 POMC OXT NPS FAAH CNR1
39 alcohol dependence 30.2 POMC PNOC PDYN OXT OPRM1 OPRL1
40 mental depression 30.2 POMC OXT NPS HTR3A
41 neonatal abstinence syndrome 30.1 PNOC PDYN OPRM1 OPRL1 OPRK1 OPRD1
42 obsessive-compulsive disorder 30.1 POMC PDYN OXT HTR3A
43 causalgia 30.1 TRPV1 TAC1 NPS ADRA2C ADRA2B
44 supine hypotensive syndrome 30.1 RPL34 OXT
45 acute stress disorder 30.0 POMC OXT
46 hypertension, essential 30.0 TAC1 POMC OXT NPS ADRA2C ADRA2B
47 paine syndrome 29.9 TRPV1 TAC1 PNOC OPRM1 OPRL1 NPS
48 attention deficit-hyperactivity disorder 29.9 OXT OPRM1 ADRA2C ADRA2B ADRA2A
49 schizophrenia 29.7 POMC PDYN OXT OPRM1 HTR3A FAAH
50 agnosia 29.2 TRPV1 TCF21 TAC1 RPL34 POMC PNOC

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ADRA2A ADRA2B ADRA2C CNR1 FAAH HTR3A
2 homeostasis/metabolism MP:0005376 10.13 ADRA2A ADRA2B ADRA2C CNR1 FAAH HTR3A
3 integument MP:0010771 10 CNR1 FAAH HTR3A OPRD1 OPRK1 OPRL1
4 nervous system MP:0003631 9.77 ADRA2A ADRA2C CNR1 FAAH HTR3A OPRD1
5 renal/urinary system MP:0005367 9.17 ADRA2B HTR3A OXT POMC TAC1 TCF21

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 629)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nalbuphine Approved Phase 4 20594-83-6 5311304 5360630
2
Tenoxicam Approved Phase 4 59804-37-4 5312154
3
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
4 Orange Approved Phase 4
5
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
6
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
7
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
8
Ramipril Approved Phase 4 87333-19-5 5362129
9
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
10
Eprosartan Approved Phase 4 133040-01-4 5281037
11
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
12
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
13
Trandolapril Approved Phase 4 87679-37-6 5484727
14
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
15
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
16
Lisinopril Approved, Investigational Phase 4 76547-98-3, 83915-83-7 5362119
17
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
18
Fosinopril Approved Phase 4 98048-97-6 55891
19
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
20
Enalaprilat Approved Phase 4 76420-72-9 6917719
21
Azilsartan medoxomil Approved, Investigational Phase 4 863031-21-4
22
Losartan Approved Phase 4 114798-26-4 3961
23
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
24
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
25
Zofenopril Approved Phase 4 81872-10-8
26
Fluoxymesterone Approved, Illicit Phase 4 76-43-7 6446
27
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
28
Desflurane Approved Phase 4 57041-67-5 42113
29
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
30
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
31
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
32
Pseudoephedrine Approved Phase 4 90-82-4 7028
33
Ephedrine Approved Phase 4 299-42-3 9294
34
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
35
Prilocaine Approved Phase 4 721-50-6 4906
36
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
37
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
38
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
39
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
40
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
41
Ticagrelor Approved Phase 4 274693-27-5 9871419
42
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
43
Lactulose Approved Phase 4 4618-18-2 11333
44
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
45
Nicotine Approved Phase 4 54-11-5 942 89594
46
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
47
Tapentadol Approved Phase 4 175591-23-8 9838022
48
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
49
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
50
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119

Interventional clinical trials:

(show top 50) (show all 5741)
# Name Status NCT ID Phase Drugs
1 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
2 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
3 Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy Unknown status NCT03288428 Phase 4 Nalbuphine;Morphine
4 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
5 A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
6 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
7 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
8 Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial. Unknown status NCT03018171 Phase 4 Clonidine;Sufentanil
9 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
10 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
11 Continuous Preperitoneal Versus Epidural Infusion of Local Anesthetic for Enhanced Postoperative Recovery Following Open Colorectal Surgery Unknown status NCT00915265 Phase 4
12 Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. Unknown status NCT00532662 Phase 4 S(+)-ketamine
13 Comparison of Three Different Rates of Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Coblation Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
14 Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy: a Prospective, Randomized, Double-blind Study. Unknown status NCT03394001 Phase 4 Lidocaine Hydrochloride;Ketorolac tromethamine
15 The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks Following Oromaxillofacial Reconstruction Unknown status NCT03118076 Phase 4 0.3% ropivacaine and 50 μg dexmedetomidine;Ropivacaine
16 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
17 A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section Unknown status NCT02741219 Phase 4 Normal saline;Dexmedetomidine;Sufentanil;Sufentanil and dexmedetomidine
18 Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study Unknown status NCT02733835 Phase 4 Remifentanil
19 Postoperative Analgesia After Thoracotomy Without Thoracic Epidural Analgesia: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine Patient-Controlled-Analgesia (PCA) Unknown status NCT01698203 Phase 4 ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun);Placebo;ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
20 Transversus Abdominis Plane Blocks in Patients Scheduled for an Abdominoplasty. A Prospective, Randomized, Double Blind, Comparison Between the Posterior Approach and Placebo. Unknown status NCT01278264 Phase 4 Ropivacaine 0.25%, 0.5 ml/kg;Ropivacaine 0.25%, 0.5 ml/kg
21 Comparison of the ED95 Dose of 0.075% and 0.1% Bupivacaine for Labour Analgesia in Primigravida. Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
22 Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery Unknown status NCT03014713 Phase 4 Dezocine;Flubiprofen;Dexmedetomidine
23 Analgesic and Hemodynamic Effects of Continuous Epidural Analgesia Compared to Paravertebral Block in Liver Resection Patients Unknown status NCT02909322 Phase 4
24 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
25 Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy Unknown status NCT02523846 Phase 4 morphine
26 Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial Unknown status NCT02680626 Phase 4 Magnesium Sulfate;Ropivacaine
27 Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery. Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
28 The Efficacy and the Safety of Dexmedetomidine Sedation on the PICU Patients-A Randomized, Controlled Study. Unknown status NCT02296073 Phase 4 Midazolam;Dexmedetomidine;Dexmedetomidine;Dexmedetomidine;Fentanyl
29 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
30 The Comparison of 0.15 Milligram Spinal Morphine vs.no Treatment for Morphine Requirement After Video-assisted Thoracoscopic Surgery. A Pilot Randomized Control Study Unknown status NCT01979354 Phase 4 Spinal morphine
31 Comparison of the Analgesic Efficacy of Continuous Femoral Nerve Block and Adductor Canal Block With Steroid Adjuvant in Patients Undergoing Total Knee Arthroplasty Unknown status NCT01973530 Phase 4
32 Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
33 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
34 Study Protocol "OFA: Opioid-Free Anesthesia". Unknown status NCT03124082 Phase 4 Remifentanil;Ketamine;Lidocaine;Clonidine
35 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
36 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
37 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
38 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
39 Use of Home Pumps for Analgesia After Ambulatory Foot Surgery - Comparison of Two Infusion Rates - a Randomized, Double-Blind Study Unknown status NCT00600899 Phase 4
40 Postoperative Analgesia in Total Hip Replacement: a Comparison of the Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic With Intrathecal Morphine. Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
41 Tablet vs. Liquid Suspension Ibuprofen in the Relief of Pain Unknown status NCT01681667 Phase 4 Ibuprofen
42 Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study Unknown status NCT02570230 Phase 4 Ketamine
43 Does Preemptive Epidural Morphine Prevent Remifentanil Induced Hyperalgesia Unknown status NCT03225690 Phase 4 Morphine;Serum physiologic
44 Efficacy of Lidocaine as Local Anesthetics in Children Under Procedural Sedation and Analgesia Using Ketamine Unknown status NCT02205502 Phase 4 Lidocaine;Normal saline
45 Randomised Controlled Trail of Warmed Humidified Insufflation Versus Cold Non-Humidified Insufflation in Elective Laparoscopic Cholecystectomies: Does This Reduce Post-Operative Pain? Unknown status NCT00792389 Phase 4
46 Postoperative Pain Management After Minimally Invasive Esophagectomy Unknown status NCT02042313 Phase 4
47 Intraoperative Use of Dexketoprofen Trometamol, Tramadol Hcl, Pethidine Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication Unknown status NCT01558622 Phase 4 dexketoprofen trometamol;tramadol hydrochloride;pethidine hydrochloride;dexketoprofen trometamol + tramadol hydrochloride;dexketoprofen trometamol + pethidine hydrochloride;vitamin c
48 Phase IV Recruiting Unknown status NCT01542697 Phase 4 intraperitoneal nebulisation of magnesium sulphate
49 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
50 Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on the Patients That is Undergoing Abdominal Hysterectomy Unknown status NCT02092012 Phase 4 dexketoprofen trometamol;Dexmedetomidine

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

40
Breast, Brain, Testes, Liver, Lung, Heart, Colon

Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30002)
# Title Authors PMID Year
1
Pectoralis (PecS) nerve block 1 for port-a-cath removal and central venous catheter (CVC) replacement. 61
32253905 2020
2
Commentary: Implementation of a Standardized Multimodal Postoperative Analgesia Protocol Improves Pain Control, Reduces Opioid Consumption, and Shortens Length of Hospital Stay After Posterior Lumbar Spinal Fusion. 61
31555813 2020
3
Implementation of a Standardized Multimodal Postoperative Analgesia Protocol Improves Pain Control, Reduces Opioid Consumption, and Shortens Length of Hospital Stay After Posterior Lumbar Spinal Fusion. 61
31414128 2020
4
Randomized Prospective Study Evaluating Single-Injection Paravertebral Block, Paravertebral Catheter, and Thoracic Epidural Catheter for Postoperative Regional Analgesia After Video-Assisted Thoracoscopic Surgery. 61
32144059 2020
5
Flurbiprofen axetil for postoperative analgesia in upper abdominal surgery: a randomized, parallel controlled, double-blind, multicenter clinical study. 61
31925579 2020
6
Prescription analgesia and adjuvant use by pain severity at admission among nursing home residents with non-malignant pain. 61
32363421 2020
7
The impact of epidural analgesia on the mode of delivery in nulliparous women that attain the second stage of labor. 61
30608007 2020
8
Effect of obesity on labor duration among nulliparous women with epidural analgesia. 61
30394154 2020
9
Choosing the Best Method for Postoperative Regional Analgesia After Video-Assisted Thoracoscopic Surgery. 61
32253088 2020
10
Analgesia: What Makes Cats Different/Challenging and What Is Critical for Cats? 61
32354487 2020
11
Effects of Adding Oxycodone to Ropivacaine on Labor Analgesia: A Randomized Controlled Trial: Erratum. 61
32487916 2020
12
The Impact of Epidural Analgesia on Perioperative Morbidity or Mortality after Open Abdominal Aortic Aneurysm Repair. 61
31672606 2020
13
Paravertebral block for radiologically inserted gastrostomy tube placement in amyotrophic lateral sclerosis. 61
32297335 2020
14
Intercostal Nerve Block with Liposomal Bupivacaine vs Epidural Analgesia for the Treatment of Traumatic Rib Fracture. 61
32081750 2020
15
A Comparison of Intrathecal and Intravenous Morphine for Analgesia After Hepatectomy: A Randomized Controlled Trial. 61
32112166 2020
16
Opioid sparing multimodal analgesia treats pain after head and neck microvascular reconstruction. 61
31765034 2020
17
Fascial Plane Blocks for Cardiac Surgery: New Frontiers in Analgesia and Nomenclature. 61
32541586 2020
18
Epidural Analgesia for Adult Undergoing Cardiac Surgery With or Without Cardiopulmonary Bypass. 61
32541599 2020
19
Combination of sufentanil, dexmedetomidine and ropivacaine to improve epidural labor analgesia effect: A randomized controlled trial. 61
32537010 2020
20
Adverse effect of delayed pushing on postpartum blood loss in nulliparous women with epidural analgesia. 61
32364638 2020
21
Correspondence: Adverse effect of delayed pushing on postpartum blood loss in nulliparous women with epidural analgesia. 61
32365224 2020
22
Regional Anesthesia in Cardiac Surgery: An Overview of Fascial Plane Chest Wall Blocks. 61
32032103 2020
23
Gerard W. Ostheimer Lecture: What's New in Obstetric Anesthesia 2018. 61
32149754 2020
24
A20 enhances mu-opioid receptor function by inhibiting beta-arrestin2 recruitment. 61
32471718 2020
25
Hypnosis as Sole Anesthesia for Dental Removal in a Patient with Multiple Chemical Sensitivity. 61
32543265 2020
26
Novel use of a continuous PECS II block for mastitis pain treatment. 61
32371498 2020
27
Safety guideline: neurological monitoring associated with obstetric neuraxial block 2020: A joint guideline by the Association of Anaesthetists and the Obstetric Anaesthetists' Association. 61
32115697 2020
28
Dopamine D1 or D3 receptor modulators prevent morphine tolerance and reduce opioid withdrawal symptoms. 61
32335101 2020
29
The Response of the Anesthesia & Analgesia Community to COVID-19. 61
32541582 2020
30
Peripheral nerve blocks for analgesia after elective total hip arthroplasty. 61
32078152 2020
31
Complex Disease Management: Managing a Cat with Comorbidities. 61
32389353 2020
32
Opioid-free postoperative analgesia: Is it feasible? 61
32546291 2020
33
Opioid-free postoperative analgesia: is it feasible? 61
32546293 2020
34
Patient-controlled subcutaneous analgesia using sufentainil or morphine in home care treatment in patients with stage III-IV cancer: A multi-center randomized controlled clinical trial. 61
32500675 2020
35
Comparison of intrathecal morphine with continuous patient-controlled epidural anesthesia versus intrathecal morphine alone for post-cesarean section analgesia: a randomized controlled trial. 61
32493372 2020
36
Impaired hemodynamic activity in the right dorsolateral prefrontal cortex is associated with impairment of placebo analgesia and clinical symptoms in postherpetic neuralgia. 61
32095656 2020
37
How Safe Is it to Use Nonsteroid Anti-inflammatory Drugs for Post-tonsillectomy Analgesia in Children? Implications for Clinical ENT Practice. 61
32351773 2020
38
Successful utilisation of epidural analgesia for perioperative pain management in a child with sodium voltage-gated channel alpha subunit (SCN1A) gene mutation. 61
32532910 2020
39
Comparison of the ultrasound-guided single-injection femoral triangle block versus adductor canal block for analgesia following total knee arthroplasty: a randomized, double-blind trial. 61
32533332 2020
40
Comparison of analgesic efficacy of continuous transversus abdominis plane block with continuous epidural analgesia in patients undergoing abdominal surgery: a systematic review and meta-analysis. 61
32485123 2020
41
Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study). 61
32565458 2020
42
Effects of Oxycodone Combined With Flurbiprofen Axetil on Postoperative Analgesia and Immune Function in Patients Undergoing Radical Resection of Colorectal Cancer. 61
32567233 2020
43
The efficacy of transversus abdominis plane block with or without dexmedetomidine for postoperative analgesia in renal transplantation. A randomized controlled trial. 61
32502705 2020
44
Effects of perioperative magnesium sulfate infusion on intraoperative blood loss and postoperative analgesia in patients undergoing posterior lumbar spinal fusion surgery: A randomized controlled trial. 61
32521394 2020
45
Factors associated with complete outward migration of postoperative epidural analgesia catheters placed for oncologic surgery: A 10-year single-center retrospective study. 61
32521432 2020
46
Chronic adverse effects after an axillary lymphadenectomy in breast cancer patients after administering weaker and stronger postoperative analgesia: results of a prospective double-blind randomized study. 61
32557338 2020
47
Oral Ondansetron to Reduce Vomiting in Children Receiving Intranasal Fentanyl and Inhaled Nitrous Oxide for Procedural Sedation and Analgesia: A Randomized Controlled Trial. 61
31983494 2020
48
Comparison of ultrasound guided Erector Spinae Plane Block and quadratus lumborum block for postoperative analgesia in laparoscopic cholecystectomy patients; a prospective randomized study. 61
31862217 2020
49
Implementation of an Enhanced Recovery Protocol (ERP) is associated with an increase in the perioperative use of non-opioid multimodal analgesia for non-ERP patients. 61
31866015 2020
50
The Canturk combination: Erector spinae plane block and femoral nerve block for postoperative analgesia after coronary artery by-pass grafting surgery. 61
31927235 2020

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

Pathways related to Pain Agnosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 TAC1 POMC PNOC PDYN OXT OPRM1
2
Show member pathways
12.81 TRPV1 TAC1 POMC PNOC PDYN OXT
3
Show member pathways
12.2 OPRD1 ADRA2C ADRA2B ADRA2A
4
Show member pathways
12.13 POMC PDYN OPRM1 ADRA2C ADRA2B ADRA2A
5 11.67 POMC OPRM1 OPRD1
6
Show member pathways
11.59 ADRA2C ADRA2B ADRA2A
7
Show member pathways
11.49 ADRA2C ADRA2B ADRA2A
8 10.79 ADRA2C ADRA2B ADRA2A

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.29 TRPV1 TAC1 PNOC PDYN OPRM1 OPRL1
2 synapse GO:0045202 9.97 TRPV1 TAC1 PNOC OPRK1 HTR3A CNR1
3 integral component of plasma membrane GO:0005887 9.96 TRPV1 OPRM1 OPRL1 OPRK1 OPRD1 HTR3A
4 dendrite GO:0030425 9.88 TRPV1 PNOC PDYN OPRM1 OPRK1 NPFF
5 axon GO:0030424 9.85 TAC1 OPRM1 HTR3A CNR1 ADRA2C
6 neuron projection GO:0043005 9.85 TRPV1 OPRM1 OPRL1 OPRK1 OPRD1 HTR3A
7 neuronal cell body GO:0043025 9.7 TRPV1 TAC1 PNOC PDYN OPRK1 HTR3A
8 integral component of postsynaptic membrane GO:0099055 9.62 OPRM1 OPRK1 HTR3A ADRA2C
9 spine apparatus GO:0097444 9.43 OPRM1 OPRD1
10 integral component of presynaptic membrane GO:0099056 9.35 OPRM1 OPRK1 OPRD1 HTR3A CNR1
11 axon terminus GO:0043679 9.1 PNOC PDYN OPRK1 OPRD1 NPFF ADRA2C

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 POMC PNOC OXT OPRM1 OPRL1 OPRK1
2 cell-cell signaling GO:0007267 10.03 TAC1 POMC ADRA2C ADRA2B ADRA2A
3 chemical synaptic transmission GO:0007268 10.02 TAC1 PNOC PDYN OPRK1 NPFF HTR3A
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.96 TRPV1 TAC1 OXT NPFF
5 response to ethanol GO:0045471 9.95 OPRM1 OPRK1 HTR3A CNR1
6 female pregnancy GO:0007565 9.92 PNOC OXT ADRA2C ADRA2B
7 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.89 CNR1 ADRA2C ADRA2B ADRA2A
8 positive regulation of MAPK cascade GO:0043410 9.88 ADRA2C ADRA2B ADRA2A
9 glucose homeostasis GO:0042593 9.88 POMC CNR1 ADRA2A
10 platelet activation GO:0030168 9.88 ADRA2C ADRA2B ADRA2A
11 excitatory postsynaptic potential GO:0060079 9.88 TRPV1 OPRM1 NPFF HTR3A
12 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.88 OPRM1 OPRL1 OPRK1 OPRD1 ADRA2A
13 cellular response to growth factor stimulus GO:0071363 9.86 TRPV1 OPRD1 HTR3A
14 regulation of insulin secretion GO:0050796 9.86 CNR1 ADRA2C ADRA2A
15 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.85 OPRM1 OPRD1 CNR1
16 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.85 OPRM1 OPRK1 OPRD1
17 response to cocaine GO:0042220 9.85 OXT OPRM1 OPRK1 HTR3A CNR1
18 activation of protein kinase B activity GO:0032148 9.83 ADRA2C ADRA2B ADRA2A
19 G protein-coupled receptor signaling pathway GO:0007186 9.83 TAC1 POMC PNOC PDYN OXT OPRM1
20 negative regulation of blood pressure GO:0045776 9.82 OXT OPRL1 CNR1
21 positive regulation of blood pressure GO:0045777 9.8 OXT NPFF CNR1 ADRA2B
22 response to morphine GO:0043278 9.8 TAC1 OPRM1 OPRK1 NPFF CNR1
23 sensory perception of pain GO:0019233 9.8 TRPV1 TAC1 OPRM1 OPRL1 OPRK1 CNR1
24 regulation of vasoconstriction GO:0019229 9.79 ADRA2C ADRA2B ADRA2A
25 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.79 ADRA2C ADRA2B ADRA2A
26 regulation of smooth muscle contraction GO:0006940 9.78 ADRA2C ADRA2B ADRA2A
27 estrous cycle GO:0044849 9.77 OPRM1 OPRL1 OPRK1
28 eating behavior GO:0042755 9.77 OXT OPRM1 OPRL1 OPRK1 OPRD1
29 adrenergic receptor signaling pathway GO:0071875 9.75 ADRA2C ADRA2B ADRA2A
30 negative regulation of heart rate GO:0010459 9.74 TRPV1 TAC1 NPFF
31 negative regulation of norepinephrine secretion GO:0010700 9.73 ADRA2C ADRA2B ADRA2A
32 opioid receptor signaling pathway GO:0038003 9.73 OPRM1 OPRL1 OPRK1 OPRD1
33 response to food GO:0032094 9.71 OXT OPRM1
34 response to pain GO:0048265 9.71 TRPV1 TAC1
35 receptor transactivation GO:0035624 9.71 ADRA2C ADRA2B ADRA2A
36 positive regulation of ossification GO:0045778 9.7 TAC1 OXT
37 behavior GO:0007610 9.7 OPRL1 OPRK1
38 negative regulation of epinephrine secretion GO:0032811 9.7 ADRA2C ADRA2B ADRA2A
39 regulation of sensory perception of pain GO:0051930 9.7 OXT OPRM1 OPRL1 OPRK1 OPRD1 NPFF
40 positive regulation of renal sodium excretion GO:0035815 9.69 TAC1 OXT
41 maternal behavior GO:0042711 9.69 OXT OPRK1
42 positive regulation of synaptic transmission, GABAergic GO:0032230 9.69 TAC1 NPS
43 acute inflammatory response to antigenic stimulus GO:0002438 9.68 OPRM1 NPFF
44 positive regulation of uterine smooth muscle contraction GO:0070474 9.67 OXT ADRA2B
45 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.67 OPRM1 OPRL1
46 positive regulation of action potential GO:0045760 9.66 TAC1 NPS
47 sensory perception GO:0007600 9.65 PNOC PDYN OPRM1 OPRL1 OPRK1
48 conditioned place preference GO:1990708 9.64 OPRL1 OPRK1
49 positive regulation of gastric acid secretion GO:0060454 9.64 TRPV1 OPRL1
50 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.63 OPRM1 OPRK1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.92 OPRM1 OPRL1 OPRK1 OPRD1 CNR1 ADRA2C
2 peptide binding GO:0042277 9.67 OPRM1 OPRL1 OPRK1 OPRD1
3 neuropeptide hormone activity GO:0005184 9.61 PNOC OXT NPFF
4 adrenergic receptor activity GO:0004935 9.58 ADRA2C ADRA2B ADRA2A
5 receptor serine/threonine kinase binding GO:0033612 9.49 OPRK1 OPRD1
6 opioid receptor binding GO:0031628 9.48 PNOC PDYN
7 opioid peptide activity GO:0001515 9.46 PNOC PDYN
8 neuropeptide binding GO:0042923 9.46 OPRM1 OPRL1 OPRK1 OPRD1
9 epinephrine binding GO:0051379 9.43 ADRA2C ADRA2B ADRA2A
10 alpha2-adrenergic receptor activity GO:0004938 9.13 ADRA2C ADRA2B ADRA2A
11 opioid receptor activity GO:0004985 8.92 OPRM1 OPRL1 OPRK1 OPRD1

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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