MCID: PNG002
MIFTS: 52

Pain Agnosia

Categories: Mental diseases

Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 15 17
Analgesia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to constipation and withdrawal disorder. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Tenoxicam and Naproxen have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 857)
# Related Disease Score Top Affiliating Genes
1 constipation 31.5 TAC1 OPRM1 CCK
2 withdrawal disorder 31.0 POMC PDYN OPRM1 CNR1
3 irritable bowel syndrome 30.8 TRPV1 TAC1 CCK
4 migraine with or without aura 1 30.8 TRPV1 TAC1 CNR1
5 anxiety 30.7 OXT OPRL1 CNR1
6 bone cancer 30.6 TRPV1 PDYN CNR1
7 opioid abuse 30.6 PDYN OPRM1 OPRL1 CCK
8 retrograde amnesia 30.5 POMC PDYN
9 opiate dependence 30.5 TRPV1 POMC PDYN OPRM1 OPRK1 OPRD1
10 morphine dependence 30.4 TRPV1 OPRM1 OPRK1 OPRD1 CCK
11 myofascial pain syndrome 30.3 TAC1 POMC
12 opioid addiction 30.3 PNOC OPRM1 OPRK1 OPRD1 CCK
13 neonatal abstinence syndrome 30.3 OPRM1 OPRK1 OPRD1
14 drug dependence 29.7 POMC PDYN OPRM1 OPRL1 OPRK1 OPRD1
15 burning mouth syndrome 29.7 TRPV1 TAC1
16 alcohol dependence 29.0 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
17 agnosia 25.3 TRPV1 TRIM13 TAC1 SLC22A18 RPL34 PSENEN
18 increased analgesia from kappa-opioid receptor agonist, female-specific 12.5
19 chronic pain requiring intraspinal analgesia 12.2
20 indifference to pain, congenital, autosomal recessive 11.6
21 neuropathy, hereditary sensory and autonomic, type v 11.4
22 marsili syndrome 11.3
23 congenital insensitivity to pain with hyperhidrosis 11.2
24 congenital insensitivity to pain with severe intellectual disability 11.2
25 chronic pain 10.9
26 cyclic vomiting syndrome 10.7 OPRM1 CNR1
27 leiomyoma cutis 10.7 TRPV1 TAC1
28 48,xyyy 10.7
29 heroin dependence 10.6 PDYN OPRM1 OPRD1
30 autoimmune encephalitis 10.6 TRPV1 CNR1
31 stereotypic movement disorder 10.6 TAC1 CCK
32 postmenopausal atrophic vaginitis 10.6 POMC OXT
33 subacute delirium 10.6
34 epicondylitis 10.6 TAC1 LIPN
35 ileus 10.6
36 somatoform disorder 10.6 TRPV1 TAC1 OPRM1
37 uremic pruritus 10.5 OPRK1 CNR1
38 back pain 10.5
39 sick building syndrome 10.5 TRPV1 POMC
40 rare disease in surgical orthopedic 10.5
41 nasal cavity adenocarcinoma 10.5 PDYN CCK
42 inguinal hernia 10.5
43 headache 10.5
44 amnestic disorder 10.5
45 pancreas disease 10.5 TRPV1 POMC CCK
46 trigeminal nerve disease 10.5 TRPV1 TAC1 LIPN
47 overnutrition 10.5 TRPV1 POMC CNR1
48 shipyard eye 10.4 PSENEN PDYN
49 scoliosis 10.4
50 eating disorder 10.4 POMC CNR1 CCK

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ADRA2C CNR1 OPRD1 OPRK1 OPRL1 OPRM1
2 homeostasis/metabolism MP:0005376 10.07 ADRA2C CCK CNR1 LIPN OPRD1 OPRK1
3 integument MP:0010771 9.93 CNR1 OPRD1 OPRK1 OPRL1 OPRM1 OXT
4 adipose tissue MP:0005375 9.85 CNR1 OPRM1 OXT PDYN POMC TRPV1
5 nervous system MP:0003631 9.7 ADRA2C CCK CNR1 OPRD1 OPRK1 OPRL1
6 no phenotypic analysis MP:0003012 9.17 CCK CNR1 OPRD1 OPRM1 PDYN POMC

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 664)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenoxicam Approved Phase 4 59804-37-4 5312154
2
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
3 Orange Approved Phase 4
4
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3
5
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
8
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
9
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
10
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
11
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
12
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
13
Promethazine Approved, Investigational Phase 4 60-87-7 4927
14
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
15
Histamine Approved, Investigational Phase 4 51-45-6 774
16
Fosaprepitant Approved Phase 4 172673-20-0 219090
17
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
18
Hydroxyzine Approved Phase 4 68-88-2 3658
19
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
20
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
21
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
22
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
23
Nicotine Approved Phase 4 54-11-5 942 89594
24
Lactulose Approved Phase 4 4618-18-2 11333
25
Butorphanol Approved, Illicit, Vet_approved Phase 4 58786-99-5, 42408-82-2 5361092
26
Tapentadol Approved Phase 4 175591-23-8 9838022
27
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
28
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
29
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
30
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
31
Esomeprazole Approved, Investigational Phase 4 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
32
Ziconotide Approved Phase 4 107452-89-1 447451
33
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
34
Dimenhydrinate Approved Phase 4 523-87-5 441281
35
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
36
Etomidate Approved Phase 4 33125-97-2 36339 667484
37
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
38
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
39
Loperamide Approved Phase 4 53179-11-6 3955
40
Glycerol Approved, Investigational Phase 4 56-81-5 753
41
Belladonna Approved, Experimental Phase 4
42
Dalteparin Approved Phase 4 9005-49-6
43
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
44
Flavoxate Approved Phase 4 15301-69-6 3354
45
Methylnaltrexone Approved Phase 4 916055-93-1, 83387-25-1 6603824
46
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
47
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
48
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
49
Pamidronate Approved Phase 4 40391-99-9 4674
50
Bisacodyl Approved Phase 4 603-50-9

Interventional clinical trials:

(show top 50) (show all 5112)
# Name Status NCT ID Phase Drugs
1 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
2 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
3 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
4 A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
5 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
6 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
7 Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial. Unknown status NCT03018171 Phase 4 Clonidine;Sufentanil
8 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
9 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
10 Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. Unknown status NCT00532662 Phase 4 S(+)-ketamine
11 Comparison of Three Different Rates of Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Coblation Tonsillectomy or Adeno-tonsillectomy in Children Unknown status NCT02205580 Phase 4 continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion;continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion
12 The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks Following Oromaxillofacial Reconstruction Unknown status NCT03118076 Phase 4 0.3% ropivacaine and 50 μg dexmedetomidine;Ropivacaine
13 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
14 A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section Unknown status NCT02741219 Phase 4 Normal saline;Dexmedetomidine;Sufentanil;Sufentanil and dexmedetomidine
15 Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study Unknown status NCT02733835 Phase 4 Remifentanil
16 Postoperative Analgesia After Thoracotomy Without Thoracic Epidural Analgesia: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine Patient-Controlled-Analgesia (PCA) Unknown status NCT01698203 Phase 4 ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun);Placebo;ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
17 Comparison of the ED95 Dose of 0.075% and 0.1% Bupivacaine for Labour Analgesia in Primigravida. Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
18 Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery Unknown status NCT03014713 Phase 4 Dezocine;Flubiprofen;Dexmedetomidine
19 Transversus Abdominis Plane Blocks in Patients Scheduled for an Abdominoplasty. A Prospective, Randomized, Double Blind, Comparison Between the Posterior Approach and Placebo. Unknown status NCT01278264 Phase 4 Ropivacaine 0.25%, 0.5 ml/kg;Ropivacaine 0.25%, 0.5 ml/kg
20 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
21 Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy Unknown status NCT02523846 Phase 4 morphine
22 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy : Prospective Double Blind, Randomized, Placebo-Controlled Study Unknown status NCT00480142 Phase 4 Oxycodone 10 mg
23 Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery. Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
24 The Efficacy and the Safety of Dexmedetomidine Sedation on the PICU Patients-A Randomized, Controlled Study. Unknown status NCT02296073 Phase 4 Midazolam;Dexmedetomidine;Dexmedetomidine;Dexmedetomidine;Fentanyl
25 Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial Unknown status NCT02680626 Phase 4 Magnesium Sulfate;Ropivacaine
26 The Comparison of 0.15 Milligram Spinal Morphine vs.no Treatment for Morphine Requirement After Video-assisted Thoracoscopic Surgery. A Pilot Randomized Control Study Unknown status NCT01979354 Phase 4 Spinal morphine
27 Comparison of the Analgesic Efficacy of Continuous Femoral Nerve Block and Adductor Canal Block With Steroid Adjuvant in Patients Undergoing Total Knee Arthroplasty Unknown status NCT01973530 Phase 4
28 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
29 Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
30 Study Protocol "OFA: Opioid-Free Anesthesia". Unknown status NCT03124082 Phase 4 Remifentanil;Ketamine;Lidocaine;Clonidine
31 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
32 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
33 A Randomized Controlled Trial Comparing Combined Spinal- Epidural Dosing Strategies for External Cephalic Version Unknown status NCT01991743 Phase 4 Group 2.5;Group 5;Group 7.5;Group 10
34 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
35 Use of Home Pumps for Analgesia After Ambulatory Foot Surgery - Comparison of Two Infusion Rates - a Randomized, Double-Blind Study Unknown status NCT00600899 Phase 4
36 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
37 Tablet vs. Liquid Suspension Ibuprofen in the Relief of Pain Unknown status NCT01681667 Phase 4 Ibuprofen
38 Postoperative Analgesia in Total Hip Replacement: a Comparison of the Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic With Intrathecal Morphine. Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
39 Efficacy of Regional Analgesia Techniques (Quadratus Lumborum Block and Transversus Abdominis Plane Block) in Acute and Chronic Pain Treatment in Patients After Cesarean Delivery Unknown status NCT03244540 Phase 4 Ropivacaine;Paracetamol;Metamizol;Ketoprofen;Bupivacaine
40 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
41 Comparison of Preemptive Analgesic Effects of Dexketoprofen Versus Dexmedetomidine on the Patients That is Undergoing Abdominal Hysterectomy Unknown status NCT02092012 Phase 4 dexketoprofen trometamol;Dexmedetomidine
42 Postoperative Pain Management After Minimally Invasive Esophagectomy Unknown status NCT02042313 Phase 4
43 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
44 Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction Unknown status NCT02923128 Phase 4 Dexmedetomidine;Sufentanyl;Saline
45 Randomised Controlled Trail of Warmed Humidified Insufflation Versus Cold Non-Humidified Insufflation in Elective Laparoscopic Cholecystectomies: Does This Reduce Post-Operative Pain? Unknown status NCT00792389 Phase 4
46 Intraoperative Use of Dexketoprofen Trometamol, Tramadol Hcl, Pethidine Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication Unknown status NCT01558622 Phase 4 dexketoprofen trometamol;tramadol hydrochloride;pethidine hydrochloride;dexketoprofen trometamol + tramadol hydrochloride;dexketoprofen trometamol + pethidine hydrochloride;vitamin c
47 Phase IV Recruiting Unknown status NCT01542697 Phase 4 intraperitoneal nebulisation of magnesium sulphate
48 Post-operative Analgesia Efficacy Using Ultrasound-guided Transmuscular Quadratus Lumborum Block Versus Ultrasound-guided Quadratus Lumborum Type II Block. Unknown status NCT03100994 Phase 4 Bupivacaine
49 Evaluation of the Postoperative Analgesic Efficacy of Bilateral Superficial Cervical Block for Thyroidectomy and Mini Incision Under General Balanced Anesthesia: a Randomized, Triple Masked, Placebo Controlled Trial. Unknown status NCT01171885 Phase 4 0.9% saline;Ropivacaine;Ropivacaine
50 Oxycodone vs. Fentanyl in the Treatment of Early Postoperative Pain After Total Hip Replacement Unknown status NCT03019562 Phase 4 Oxycodone;Fentanyl

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

41
Breast, Brain, Testes, Liver, Lung, Colon, Heart

Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30002)
# Title Authors PMID Year
1
Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review. 38
30873885 2019
2
Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision. 38
30672394 2019
3
A modified approach of rhomboid intercostal block for postoperative analgesia in modified radical mastectomy: Ultrasound guided bi-level high thoracic injection. 38
30851500 2019
4
Ultrasound-guided erector spinae plane block versus oblique subcostal transversus abdominis plane block for postoperative analgesia of adult patients undergoing laparoscopic cholecystectomy: Randomized, controlled trial. 38
30851501 2019
5
The successful usage of modified thoracoabdominal nerves block through perichondrial approach (M-TAPA) for analgesia of laparoscopic ventral hernia repair. 38
30831469 2019
6
Ultrasound-guided bilateral lumbar erector spinae plane block for postoperative analgesia after spondylolisthesis correction surgery. 38
30903940 2019
7
Effects of combined spinal-epidural analgesia on first stage of labor: a cohort study. 38
29768964 2019
8
A combination of inhaled nitrous oxide and low-dose ketamine infusion for labor analgesia. 38
30875519 2019
9
Lumbar thoracolumbar interfascial plane block provides effective analgesia for spondylosis. 38
30851502 2019
10
Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials. 38
31202161 2019
11
Intercostal nerve cryoablation for control of traumatic rib fracture pain: A case report. 38
31388539 2019
12
Analgesia-first sedation in critically ill adults: A U.S. pilot, randomized controlled trial. 38
31228760 2019
13
Subcutaneous brompheniramine for cutaneous analgesia in rats. 38
31319069 2019
14
Comparative Evaluation of Intranasal Butorphanol and Oral Diclofenac Sodium for Analgesia After Surgical Removal of Impacted Mandibular Third Molars: Split-Mouth Prospective Controlled Clinical Study. 38
31371881 2019
15
Virtual Reality interventions for acute and chronic pain management. 38
31306747 2019
16
Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy. 38
31410119 2019
17
4% Articaine and 2% Lignocaine for Surgical Removal of Third Molar by Mandibular Nerve Block: A Randomized Clinical Trial for Efficacy and Safety. 38
31371883 2019
18
A survey of antenatal and peripartum provision of information on analgesia and anaesthesia. 38
31256437 2019
19
Hypnotic communication for periprocedural analgesia during transcatheter ablation of atrial fibrillation. 38
31388561 2019
20
Ropivacaine vs. levobupivacaine: Analgesic effect of combined spinal-epidural anesthesia during childbirth and effects on neonatal Apgar scores, as well as maternal vital signs. 38
31410181 2019
21
Determinants of women's dissatisfaction with anaesthesia care in labour and delivery. 38
31264207 2019
22
A biased coin up-and-down sequential allocation trial to determine the optimum programmed intermittent epidural bolus time interval between 5 mL boluses of bupivacaine 0.125% with fentanyl 2 µg·mL-1. 38
31152372 2019
23
Opioid-sparing effects of cannabinoids on morphine analgesia: participation of CB1 and CB2 receptors. 38
31218677 2019
24
Device-Related Error in Patient-Controlled Analgesia: Analysis of 82,698 Patients in a Tertiary Hospital. 38
31425211 2019
25
Parasympathetic Tone Activity Evaluation to Discriminate Ketorolac and Ketorolac/Tramadol Analgesia Level in Swine. 38
31425233 2019
26
The Effect of Labor Epidural Analgesia on Breastfeeding Outcomes: A Prospective Observational Cohort Study in a Mixed-Parity Cohort. 38
31425221 2019
27
Bilateral Thoracic Paravertebral Blocks Compared to Thoracic Epidural Analgesia After Midline Laparotomy: A Pragmatic Noninferiority Clinical Trial. 38
31425230 2019
28
Benefits of a multimodal analgesia compared to local anesthesia alone to alleviate pain following castration in sheep: a multiparametric approach. 38
30808432 2019
29
Adductor canal versus femoral triangle anatomical locations for continuous catheter analgesia after total knee arthroplasty: a multicentre randomised controlled study. 38
31056239 2019
30
The usage of single-shot ultrasound guided rhomboid intercostal block for analgesia after thoracotomy: Clinical experience in two patients. 38
30708149 2019
31
Comparison of ultrasound-guided thoracolumbar interfascial plane block versus wound infiltration for postoperative analgesia after single-level discectomy. 38
30743153 2019
32
Pectoralis-II Myofascial Block and Analgesia in Breast Cancer Surgery: A Systematic Review and Meta-analysis. 38
31408448 2019
33
Rhomboid intercostal and sub-serratus (RISS) plane block for analgesia after lung transplant. 38
30703673 2019
34
Pain Control in the Cardiothoracic Surgery Patient. 38
31351557 2019
35
Technological Advances in Exotic Pet Anesthesia and Analgesia. 38
31395323 2019
36
Brain mechanisms of social touch-induced analgesia in females. 38
31241496 2019
37
Post-nail procedure analgesia: A randomized control pilot study. 38
31085268 2019
38
Clinical insights: Equine anaesthesia and analgesia. 38
31373059 2019
39
Enhanced preoperative education about continuous femoral nerve block with patient-controlled analgesia improves the analgesic effect for patients undergoing total knee arthroplasty and reduces the workload for ward nurses. 38
31409300 2019
40
The impact of ultrasound-guided continuous serratus anterior plane block versus intravenous patient-controlled analgesia on the incidence and severity of post-thoracotomy pain syndrome: A randomized, controlled study. 38
31433893 2019
41
Comparison of analgesic interventions for traumatic rib fractures: a systematic review and meta-analysis. 38
29411048 2019
42
Expanding role of multimodal analgesia in facilitating recovery after surgery: From fast-tracking to enhanced recovery. 38
30622044 2019
43
Prehospital Analgesia With Intranasal Ketamine (PAIN-K): A Randomized Double-Blind Trial in Adults. 38
30926189 2019
44
Single-shot interscalene block with periarticular local infiltration analgesia for shoulder arthroplasty. 38
31339026 2019
45
Nociceptive-like behavior and analgesia in silver catfish (Rhamdia quelen). 38
31408639 2019
46
Comparative analgesia between acupuncture and dipyrone in odontalgia. 38
31404683 2019
47
Dextromethorphan Analgesia in a Human Experimental Model of Hyperalgesia. 38
31094746 2019
48
[Evaluation of pain in children of 2, 4 and 6 months after the application of non-pharmacological analgesia methods during vaccination]. 38
30448108 2019
49
Local anaesthetic infiltration via wound catheter versus epidural analgesia in open hepatectomy: a systematic review and meta-analysis of randomised controlled trials. 38
30879991 2019
50
Adductor canal block versus local infiltration analgesia for postoperative pain after anterior cruciate ligament reconstruction: a single centre randomised controlled triple-blinded trial. 38
31130273 2019

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.85 TAC1 OPRM1 CNR1 CCK ADRA2C
2 neuronal cell body GO:0043025 9.73 TRPV1 TAC1 PNOC PDYN OPRK1 CCK
3 perikaryon GO:0043204 9.67 OPRM1 OPRK1 NPFF CCK
4 integral component of postsynaptic membrane GO:0099055 9.61 OPRM1 OPRK1 ADRA2C
5 dendrite GO:0030425 9.5 TRPV1 PNOC PDYN OPRM1 OPRK1 NPFF
6 integral component of presynaptic membrane GO:0099056 9.46 OPRM1 OPRK1 OPRD1 CNR1
7 spine apparatus GO:0097444 9.32 OPRM1 OPRD1
8 axon terminus GO:0043679 9.1 PNOC PDYN OPRK1 OPRD1 NPFF ADRA2C
9 plasma membrane GO:0005886 10.26 TRPV1 TAC1 SLC22A18 PSENEN PNOC PDYN
10 integral component of plasma membrane GO:0005887 10.01 TRPV1 PSENEN OPRM1 OPRL1 OPRK1 OPRD1

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.96 TAC1 PNOC PDYN OPRK1 NPFF
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 TRPV1 TAC1 OXT NPFF
3 response to ethanol GO:0045471 9.83 OPRM1 OPRK1 CNR1
4 female pregnancy GO:0007565 9.83 PNOC OXT ADRA2C
5 memory GO:0007613 9.81 OXT CNR1 CCK
6 sensory perception of pain GO:0019233 9.8 TRPV1 TAC1 OPRM1 OPRL1 OPRK1 CNR1
7 excitatory postsynaptic potential GO:0060079 9.79 TRPV1 OPRM1 NPFF
8 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.78 OPRM1 OPRD1 CNR1
9 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.78 OPRM1 OPRL1 OPRK1 OPRD1
10 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.77 OPRM1 OPRK1 OPRD1
11 response to morphine GO:0043278 9.77 TAC1 OPRM1 OPRK1 NPFF CNR1
12 response to cocaine GO:0042220 9.76 OXT OPRM1 OPRK1 CNR1
13 negative regulation of blood pressure GO:0045776 9.74 OXT OPRL1 CNR1
14 sensory perception GO:0007600 9.73 PNOC OPRM1 OPRL1 OPRK1
15 opioid receptor signaling pathway GO:0038003 9.71 OPRM1 OPRL1 OPRK1 OPRD1
16 positive regulation of blood pressure GO:0045777 9.7 OXT NPFF CNR1
17 maternal process involved in female pregnancy GO:0060135 9.67 NPFF CNR1
18 response to food GO:0032094 9.67 OXT OPRM1
19 estrous cycle GO:0044849 9.67 OPRM1 OPRL1 OPRK1
20 response to pain GO:0048265 9.66 TRPV1 TAC1
21 positive regulation of renal sodium excretion GO:0035815 9.65 TAC1 OXT
22 positive regulation of ossification GO:0045778 9.65 TAC1 OXT
23 maternal behavior GO:0042711 9.64 OXT OPRK1
24 negative regulation of heart rate GO:0010459 9.64 TAC1 NPFF
25 negative regulation of appetite GO:0032099 9.63 NPFF CCK
26 eating behavior GO:0042755 9.63 OXT OPRM1 OPRL1 OPRK1 OPRD1 CCK
27 behavior GO:0007610 9.62 OPRL1 OPRK1
28 acute inflammatory response to antigenic stimulus GO:0002438 9.61 OPRM1 NPFF
29 positive regulation of sensory perception of pain GO:1904058 9.6 OPRL1 CCK
30 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.58 OPRM1 OPRL1
31 regulation of sensory perception of pain GO:0051930 9.56 OXT OPRM1 OPRL1 OPRK1 OPRD1 NPFF
32 positive regulation of gastric acid secretion GO:0060454 9.55 TRPV1 OPRL1
33 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.54 OPRM1 OPRK1
34 neuropeptide signaling pathway GO:0007218 9.28 TAC1 POMC PNOC PDYN OPRM1 OPRL1
35 signal transduction GO:0007165 10.21 POMC PNOC OXT OPRM1 OPRL1 OPRK1
36 G protein-coupled receptor signaling pathway GO:0007186 10.07 TAC1 POMC PNOC PDYN OXT OPRM1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 POMC OXT CCK
2 neuropeptide hormone activity GO:0005184 9.46 PNOC OXT NPFF CCK
3 receptor serine/threonine kinase binding GO:0033612 9.32 OPRK1 OPRD1
4 opioid peptide activity GO:0001515 9.26 PNOC PDYN
5 neuropeptide binding GO:0042923 9.26 OPRM1 OPRL1 OPRK1 OPRD1
6 opioid receptor activity GO:0004985 8.92 OPRM1 OPRL1 OPRK1 OPRD1

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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