MCID: PNG002
MIFTS: 51

Pain Agnosia

Categories: Mental diseases

Aliases & Classifications for Pain Agnosia

MalaCards integrated aliases for Pain Agnosia:

Name: Pain Agnosia 12 15 17
Analgesia 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060145

Summaries for Pain Agnosia

Disease Ontology : 12 An agnosia that is a loss of the ability to perceive and process pain.

MalaCards based summary : Pain Agnosia, also known as analgesia, is related to chronic pain and ileus. An important gene associated with Pain Agnosia is OPRM1 (Opioid Receptor Mu 1), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Dezocine and Pentazocine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and breast, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Pain Agnosia

Diseases related to Pain Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 895)
# Related Disease Score Top Affiliating Genes
1 chronic pain 31.9 PNOC OPRM1
2 ileus 31.5 POMC OPRM1 CCK CALCA
3 headache 31.4 TAC1 CCK CALCA
4 amnestic disorder 31.3 POMC PDYN OXT OPRM1 FOS
5 postpartum depression 31.1 PNOC OXT CALCA
6 constipation 31.1 TAC1 PDYN OPRM1 FAAH CCK CALCA
7 complex regional pain syndrome 30.9 TAC1 SCN9A POMC CALCA
8 fibromyalgia 30.9 SCN9A POMC PNOC OPRM1 CALCA
9 opioid addiction 30.8 PNOC OPRM1 OPRK1 CCK
10 opiate dependence 30.8 POMC PENK PDYN OPRM1 OPRK1 NPFF
11 irritable bowel syndrome 30.7 TRPV1 TRPA1 TAC1 POMC CCK
12 paralytic ileus 30.7 TCF21 TAC1
13 diabetic neuropathy 30.7 TRPV1 SCN9A POMC CALCA
14 reflex sympathetic dystrophy 30.7 TRPV1 TAC1 CALCA
15 withdrawal disorder 30.7 POMC PNOC PENK PDYN OPRM1 OPRK1
16 arachnoiditis 30.6 TAC1 POMC
17 algoneurodystrophy 30.6 TAC1 CALCA
18 motion sickness 30.6 TAC1 POMC OPRM1 FOS
19 bone cancer 30.6 TRPV1 PENK PDYN CALCA
20 substance abuse 30.5 POMC PDYN OPRM1
21 trigeminal neuralgia 30.5 TRPV1 TRPA1 TAC1 SCN9A LIPN FOS
22 anxiety 30.5 TAC1 POMC PNOC PDYN OXT OPRM1
23 morphine dependence 30.4 PENK PDYN OXT OPRM1 OPRK1 FOS
24 peripheral nervous system disease 30.3 TRPV1 TRPA1 TAC1 SCN9A POMC FOS
25 diarrhea 30.3 TAC1 POMC CCK CALCA
26 retrograde amnesia 30.3 POMC PDYN FOS
27 drug dependence 30.3 POMC PNOC PENK PDYN OPRM1 OPRL1
28 small cell cancer of the lung 30.2 POMC CCK CALCA
29 erythromelalgia 30.2 TRPV1 TRPA1 SCN9A
30 alcohol dependence 30.2 POMC PNOC PDYN OPRM1 OPRL1 OPRK1
31 hypochondriasis 30.2 POMC OXT
32 autism spectrum disorder 30.2 POMC PNOC OXT OPRM1 OPRL1 OPRK1
33 opioid abuse 30.1 POMC PNOC PENK PDYN OPRM1 OPRL1
34 body mass index quantitative trait locus 11 30.1 TRPV1 POMC OXT FOS FAAH CCK
35 interstitial cystitis 30.0 TRPV1 TAC1 SCN9A
36 paroxysmal extreme pain disorder 30.0 TRPV1 TRPA1 SCN9A
37 migraine with or without aura 1 30.0 TRPV1 TRPA1 TAC1 SCN9A POMC PNOC
38 cluster headache 30.0 PNOC CALCA
39 sleep disorder 30.0 TAC1 POMC PDYN FOS
40 causalgia 30.0 TRPV1 TAC1 SCN9A CALCA
41 burning mouth syndrome 29.9 TRPV1 TAC1 SCN9A CALCA
42 neonatal abstinence syndrome 29.9 PNOC PDYN OPRM1 OPRL1 OPRK1
43 obsessive-compulsive disorder 29.9 POMC PDYN OXT CCK
44 myofascial pain syndrome 29.9 TRPV1 TAC1 POMC LIPN CALCA
45 attention deficit-hyperactivity disorder 29.8 OXT OPRM1 FOS FAAH ARRB2
46 paine syndrome 29.6 TRPV1 TRPA1 TAC1 SCN9A PNOC OPRM1
47 schizophrenia 29.5 POMC PNOC PDYN OXT OPRM1 FOS
48 agnosia 29.0 TRPV1 TRPA1 TCF21 TAC1 SCN9A POMC
49 increased analgesia from kappa-opioid receptor agonist, female-specific 11.3
50 marsili syndrome 11.2

Graphical network of the top 20 diseases related to Pain Agnosia:



Diseases related to Pain Agnosia

Symptoms & Phenotypes for Pain Agnosia

MGI Mouse Phenotypes related to Pain Agnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 ARRB2 CCK FAAH FOS NPFF OPRK1
2 homeostasis/metabolism MP:0005376 10.22 ARRB2 CCK FAAH FOS LIPN NPFF
3 integument MP:0010771 10.16 ARRB2 FAAH FOS OPRK1 OPRL1 OPRM1
4 adipose tissue MP:0005375 10.01 ARRB2 FOS OPRM1 OXT PDYN PENK
5 nervous system MP:0003631 9.97 ARRB2 CCK FAAH FOS OPRK1 OPRL1
6 no phenotypic analysis MP:0003012 9.5 CCK OPRM1 PDYN PENK POMC TRPA1
7 normal MP:0002873 9.28 FAAH FOS OPRL1 OPRM1 PENK SCN9A

Drugs & Therapeutics for Pain Agnosia

Drugs for Pain Agnosia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 410)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
2
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
3
Eprosartan Approved Phase 4 133040-01-4 5281037
4
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
5
Fosinopril Approved Phase 4 98048-97-6 55891
6
Ramipril Approved Phase 4 87333-19-5 5362129
7
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
8
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
9
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
10
Trandolapril Approved Phase 4 87679-37-6 5484727
11
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
12
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
13
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
14
Azilsartan medoxomil Approved, Investigational Phase 4 863031-21-4
15
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
16
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
17
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
18
Zofenopril Approved Phase 4 81872-10-8
19
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
20
Losartan Approved Phase 4 114798-26-4 3961
21
Enalaprilat Approved Phase 4 76420-72-9 6917719
22
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
23
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
24
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3
25
Prilocaine Approved Phase 4 721-50-6 4906
26
Meperidine Approved Phase 4 57-42-1 4058
27
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
28
Etomidate Approved Phase 4 33125-97-2 36339 667484
29
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
30
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
31
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
32
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
33
Orphenadrine Approved Phase 4 83-98-7 4601
34
Butorphanol Approved, Illicit, Vet_approved Phase 4 42408-82-2, 58786-99-5 5361092
35
Nicotine Approved Phase 4 54-11-5 942 89594
36
Palonosetron Approved, Investigational Phase 4 135729-56-5, 119904-90-4 148211
37
Ondansetron Approved Phase 4 99614-02-5 4595
38
Ephedrine Approved Phase 4 299-42-3 9294
39
Pseudoephedrine Approved Phase 4 90-82-4 7028
40
Povidone-iodine Approved Phase 4 25655-41-8
41
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
42
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
43
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
44
Promethazine Approved, Investigational Phase 4 60-87-7 4927
45
Dolasetron Approved, Investigational Phase 4 115956-12-2 60654
46
Famotidine Approved Phase 4 76824-35-6 3325
47
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078
48
Nitric Oxide Approved Phase 4 10102-43-9 145068
49
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
50
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693

Interventional clinical trials:

(show top 50) (show all 2480)
# Name Status NCT ID Phase Drugs
1 Effect of Bispectral Index (BIS) Monitoring on Faster Recovery Time and Analgesic Consumption in Abdominal Surgery Patients Unknown status NCT01470898 Phase 4
2 the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation Unknown status NCT02635802 Phase 4 Remifentanil;Lidocaine;Remifentanil+Lidocaine;Midazolam
3 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
4 MethOxyflUraNe at moderaTe High AltItudes for PAIN Management: A Randomised, Double-blind, Cross-over Study Unknown status NCT03849027 Phase 4 Methoxyflurane;Placebo
5 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
6 The Pharmacokinetics of Fentanyl in Intensive Care Patients Unknown status NCT02587273 Phase 4 Fentanyl
7 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
8 Effects of Transverse Abdominis Plane Block Guided by Ultrasound on the Postoperative Analgesia and Quality of Lives Among the Patients Undergo Inguinal Hernia Repair Unknown status NCT02292095 Phase 4
9 Analgesia Comparison of Nalbuphine and Morphine for Laparoscopic Myomectomy Unknown status NCT03288428 Phase 4 Nalbuphine;Morphine
10 Oxycodone vs. Fentanyl in the Treatment of Early Postoperative Pain After Total Hip Replacement Unknown status NCT03019562 Phase 4 Oxycodone;Fentanyl
11 The Efficacy and the Safety of Dexmedetomidine Sedation on the PICU Patients-A Randomized, Controlled Study. Unknown status NCT02296073 Phase 4 Midazolam;Dexmedetomidine;Dexmedetomidine;Dexmedetomidine;Fentanyl
12 Comparing Effectiveness of Post-operative Analgesia Between Patient Re-education and the Additional of a Basal Morphine Infusion to IV-PCA Morphine in Patients With Unsatisfactory Analgesia After Laparotomy Unknown status NCT02523846 Phase 4 morphine
13 Effect of Dexamethasone or Clonidine When Given as Adjuncts to Ropivacaine for Caudal Analgesia on Duration of Analgesia Compared to Placebo in Children Unknown status NCT02773602 Phase 4 Dexamethasone;Clonidine;Normal Saline
14 A Prospective, Randomized, Control Trial of Ketorolac Versus Placebo on Opioid Analgesic Use and Complications Following Cesarean Delivery With Intra-Epidural Morphine Unknown status NCT02509312 Phase 4 Ketorolac;Epidural Morphine;Hydromorphone
15 Ketamine and Postoperative Analgesia in Children Unknown status NCT00200564 Phase 4 ketamine
16 The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery Unknown status NCT02503826 Phase 4 Sufentanil;Sufentanil;Sufentanil;Midazolam;propofol;cisatracurium
17 Analgesia After Total Knee Arthroplasty: Randomized Controlled Trial Comparing (a) Periarticular Multimodal Technique With (B) Continuous Femoral Nerve Block + Posterior Capsular Injection Unknown status NCT00869037 Phase 4 Periarticular Injection;CFNB + Posterior Capsular Injection
18 Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery Unknown status NCT03014713 Phase 4 Dezocine;Flubiprofen;Dexmedetomidine
19 Opioid-sparing Effect of Intravenous Ibuprofen Unknown status NCT03016650 Phase 4 Acetaminophen;Ibuprofen
20 Intravenous Versus Caudal Supplementation of Ketamine for Postoperative Pain Control in Children,A Double-blind Controlled Clinical Trial. Unknown status NCT00532662 Phase 4 S(+)-ketamine
21 A Randomized Controlled Trial to Compare the Efficacy and Safety of NALDEBAIN With Intravenous Patient-Controlled Analgesia With Fentanyl for the Treatment of Post-Laparotomy Surgery Unknown status NCT03296488 Phase 4 Nalbuphine Sebacate;Fentanyl Citrate
22 A Placebo-controlled, Double-blinded, Randomized Pilot Study of Bupivacaine Liposome Injectable Suspension (EXPAREL) for Minimally Invasive Supracervical Hysterectomies Postsurgical Analgesia Unknown status NCT03769714 Phase 4 Saline Solution for Injection;Exparel
23 Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
24 Novel Vital-sign Patient-assisted Intravenous Analgesia With Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration: a Prospective Cohort Study Unknown status NCT02733835 Phase 4 Remifentanil
25 Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery Unknown status NCT03534895 Phase 4 Midazolam Injectable Solution;Postoperative analgesia;Rescue analgesia;Wound infiltration;Analgesia at home
26 Postoperative Patient Controlled Epidural Analgesia After Total Knee Arthroplasty With 2ug/ml Fentanyl Combine With 0.2% Ropivacaine or 0.2% Levobupivcaine Unknown status NCT01158586 Phase 4 Levobupivacaine
27 The Effect of Early Goal Directed Sedation on Microcirculation in Septic Shock Patients With Mechanical Ventilation Unknown status NCT02612363 Phase 4 Dexmedetomidine for sedation
28 Addition of Magnesium Sulfate to Caudal for Prevention of Emergence Agitation in Children Unknown status NCT02164773 Phase 4 Magnesium Sulfate;0.9%normal saline
29 The Comparison of Efficacy and Safety of Target Controlled Infusion of Propofol or Etomidate at General Anesthesia in Geriatric Patients --A Randomized Controlled Trial. Unknown status NCT02111265 Phase 4 Remifentanil;Cisatracurium;Sufentanil
30 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty :a Randomized Clinical Trial Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
31 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
32 Assessment of Analgesic Efficacy and Safety of Intravenous Hyoscine-N-Butylbromide in Patients With Abdominal Colic Associated With Acute Gastroenteritis; a Randomized, Double-blind, Placebo Controlled Study Unknown status NCT02508142 Phase 4 Hyoscine-N-Butylbromide
33 A Single Center, Prospective Randomized Double-blind Trial: Efficacy of Nefopam and Morphine in Balanced Analgesia for Acute Ureteric Colic Unknown status NCT01543165 Phase 4 Ketorolac and nefopam balanced analgesia;Balanced analgesia using ketorolac and morphine;Pain control with single analgesics (ketorolac)
34 Effect of Programmed Intermittent Epidural Bolus Delivery Rate on the Quality of Labour Analgesia: A Randomized Clinical Trial Unknown status NCT03712735 Phase 4 Bupivacaine 0.08% - fentanyl 2mcg
35 Determination of the Minimum Local Analgesic Dose of Spinal Chloroprocaine in Labour. Unknown status NCT01909089 Phase 4 Spinal administration of chloroprocaine.
36 Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Unilateral Total Knee Arthroplasty --- A Randomized Controlled Trial Unknown status NCT02284620 Phase 4
37 Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics? - A Pilot Study. Optional Deoxyribo-Nucleic Acid Donation for the Study of Hypertension. Unknown status NCT01715584 Phase 4
38 The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients Unknown status NCT02078583 Phase 4 Fentanyl;Remifentanil;Normal saline
39 A Multicenter Study: Dexmedetomidine Combined With Sufentanil for Patient Controlled Intravenous Analgesia After Caesarean Section Unknown status NCT02741219 Phase 4 Normal saline;Dexmedetomidine;Sufentanil;Sufentanil and dexmedetomidine
40 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
41 Postoperative Analgesia in Total Hip Replacement: a Comparison of the Analgesic Efficacy of Periarticular Infiltration of Local Anaesthetic With Intrathecal Morphine. Unknown status NCT01312077 Phase 4 Levobupivacaine;Intrathecal morphine
42 Comparing the Delivery of Local Anesthetic by Programmed Intermittent Bolus Versus Continuous Infusion Through a Popliteal Sciatic Nerve Catheter for Analgesia Following Major Ankle Surgery Unknown status NCT02707874 Phase 4 CI 0.2% ropivacaine;PIB 0.2% ropivacaine
43 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
44 The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia:A Randomized, Double Blind Controlled Trial Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
45 Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice: a Prospective Randomized Double Blind, Placebo-controlled Clinical Trial Unknown status NCT01303614 Phase 4 Lidocaine-Prilocaine cream;placebo
46 Comparison of the ED95 Dose of 0.075% and 0.1% Bupivacaine for Labour Analgesia in Primigravida. Unknown status NCT02116842 Phase 4 0.1% bupivacaine;0.075% bupivacaine;40 µg fentanyl
47 Use of Home Pumps for Analgesia After Ambulatory Foot Surgery - Comparison of Two Infusion Rates - a Randomized, Double-Blind Study Unknown status NCT00600899 Phase 4
48 Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy Unknown status NCT00209885 Phase 4 Gabapentin;S-ketamine;Lidocaine;Droperidol
49 Optimal Multimodal Analgesia in Abdominal Hysterectomy Unknown status NCT00209872 Phase 4 Gabapentin;Lidocaine;S-ketamine
50 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine

Search NIH Clinical Center for Pain Agnosia

Genetic Tests for Pain Agnosia

Anatomical Context for Pain Agnosia

MalaCards organs/tissues related to Pain Agnosia:

40
Brain, Liver, Breast, Spinal Cord, Bone, Skin, Heart

Publications for Pain Agnosia

Articles related to Pain Agnosia:

(show top 50) (show all 30003)
# Title Authors PMID Year
1
A measure of expectancies for alcohol analgesia: Preliminary factor analysis, reliability, and validity. 61
33460990 2021
2
Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products. 61
33485984 2021
3
Effects of transcutaneous electrical acupoint stimulation on perioperative immune function and postoperative analgesia in patients undergoing radical mastectomy: A randomized controlled trial. 61
33488793 2021
4
Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system. 61
33115718 2021
5
Post-operative pain behaviour associated with surgical castration in donkeys (Equus asinus). 61
32525236 2021
6
Quadratus lumborum block vs. transversus abdominis plane block for caesarean delivery: a systematic review and network meta-analysis. 61
32621529 2021
7
Preoperative Pressure Pain Threshold Is Associated With Postoperative Pain in Short-Stay Anorectal Surgery: A Prospective Observational Study. 61
32675636 2021
8
European Society of Anaesthesiology and Intensive Care Guidelines on peri-operative use of ultrasound for regional anaesthesia (PERSEUS regional anesthesia): Peripheral nerves blocks and neuraxial anaesthesia. 61
33186303 2021
9
New composite scale for evaluating peripheral nerve block quality in upper limb orthopaedics surgery. 61
32063339 2021
10
A Survey-Based Study Into the Use of Peripheral Nerve Blocks for Pelvic Limb Surgery Among Veterinary Professionals With an Interest in Anesthesia. 61
33346162 2021
11
The relationship between resited epidural catheters after secondary epidural catheter failure and vaginal delivery: A retrospective case-control study. 61
33147366 2021
12
Exploring the medicalisation of childbirth through women's preferences for and use of pain relief. 61
32094035 2021
13
Epidural Versus Transabdominal Wall Catheters: A Comparative Study of Outcomes After Pancreatic Resection. 61
33070995 2021
14
Comparison of Chloroprocaine Versus Lidocaine With Epinephrine, Sodium Bicarbonate, and Fentanyl for Epidural Extension Anesthesia in Elective Cesarean Delivery: A Randomized, Triple-Blind, Noninferiority Study. 61
32852294 2021
15
Two prophylactic pain management regimens for medical abortion ≤63 days' gestation with mifepristone and misoprostol: A multicenter, randomized, placebo-controlled trial. 61
33451721 2021
16
Analgesic effect of music during wound care among patients with diaphyseal tibial fractures: Randomized controlled trial. 61
33135319 2021
17
Morphine-Conditioned Placebo Analgesia in Female and Male Rats with Chronic Neuropathic Pain: c-Fos Expression in the Rostral Ventromedial Medulla. 61
33285237 2021
18
Analgesia and side effects of codeine phosphate associated with paracetamol vs. paracetamol after the extraction of mandibular third molars: a randomized double-blind clinical trial using the split-mouth model. 61
32725573 2021
19
Efficacy of erector spinae plane block for analgesia in breast surgery: a systematic review and meta-analysis. 61
32609389 2021
20
Multimodal analgesia after thyroid or parathyroid surgery: A randomized controlled trial. 61
32977975 2021
21
Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry. 61
33400930 2021
22
Buprenorphine Analgesia Reduces Survival With ALM Resuscitation in a Rat Model of Uncontrolled Hemorrhage: Concerns for Trauma-Related Research. 61
32925604 2021
23
The Effect of the No Pain Labor & Delivery-Global Health Initiative on Cesarean Delivery and Neonatal Outcomes in China: An Interrupted Time-Series Analysis. 61
32332290 2021
24
Hydromorphone versus morphine: a historical cohort study to evaluate the quality of postoperative analgesia. 61
33170454 2021
25
Thoracic Epidural Analgesia for Postoperative Pain Management in Liver Transplantation: A 10-year Study on 685 Liver Transplant Recipients. 61
33437863 2021
26
Modified thoracoabdominal sensory nerves block through subcostal exterior semilunaris approach (SE-TAP) provide broader analgesia for abdominal surgery. 61
33120300 2021
27
Sedation, Analgesia, and Paralysis in COVID-19 Patients in the Setting of Drug Shortages. 61
32844730 2021
28
Dexamethasone Addition to Popliteal Nerve Blocks: Effects on Duration of Analgesia and Incidence of Postoperative Nerve Complication. 61
31904292 2021
29
Transversus Abdominis Plane Block Appears to Be Effective and Safe as a Part of Multimodal Analgesia in Bariatric Surgery: a Meta-analysis and Systematic Review of Randomized Controlled Trials. 61
33083978 2021
30
Clinical effect of normal saline injectate into interscalene nerve block catheters given within one hour of local anesthetic bolus on analgesia and hemidiaphragmatic paralysis. 61
33184166 2021
31
Addition of dexamethasone to local infiltration analgesia in elective total knee arthroplasty: double-blind, randomized control trial. 61
33199379 2021
32
Impact of Auricular Neurostimulation in Patients Undergoing Colorectal Surgery with an Enhanced Recovery Protocol: A Pilot Randomized, Controlled Trial. 61
33417346 2021
33
Remifentanil labor analgesia in a parturient with Brugada syndrome. 61
32536043 2021
34
Postoperative pain after intrathecal analgesia in laparoscopic liver resection: a retrospective chart review. 61
33594875 2021
35
Effects of an individualized analgesia protocol on the need for medical interventions after adenotonsillectomy in children: a randomized controlled trial. 61
33557762 2021
36
An Analgesic Regimen for Opioid Reduction in Elective Plastic Surgery: A Randomized Prospective Study. 61
33565839 2021
37
Dermatomal coverage of single-injection ultrasound-guided parasagittal approach to anterior quadratus lumborum block at the lateral supra-arcuate ligament. 61
33550463 2021
38
Efficacy of the erector spinae plane (ESP) block for quality of recovery in posterior thoraco-lumbar spinal decompression surgery: study protocol for a randomised controlled trial. 61
33596968 2021
39
Investigation of correlations between pain modulation paradigms. 61
33587117 2021
40
Pharmacokinetics of Morphine and Morphine-6-Glucuronide During Postoperative Pain Therapy in Cardiac Surgery Patients. 61
33547559 2021
41
Effect of preoperative intravenous vs oral acetaminophen on postoperative opioid consumption in an enhanced recovery after surgery (ERAS) program in patients undergoing open gynecologic oncology surgery. 61
33298309 2021
42
Motor-sparing nerve blocks for total knee replacement: A scoping review. 61
33035871 2021
43
Intracranial subdural haematoma following dural puncture accidental: clinical case. 61
32854941 2021
44
Parascapular Sub-Iliocostalis Plane Block: Comparative Description of a Novel Technique for Posterior Rib Fractures. 61
33586285 2021
45
Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations. 61
33603216 2021
46
Efficacy and Safety of Methylnaltrexone for the Treatment of Opioid-Induced Constipation: A Meta-analysis of Randomized Controlled Trials. 61
33575953 2021
47
Using a clinical judgement model to understand the impact of validated pain assessment tools for burn clinicians and adult patients in the ICU: A multi-methods study. 61
33277094 2021
48
Superficial cervical plexus block alone or combined with interscalene brachial plexus block in surgery for clavicle fractures: a randomized clinical trial. 61
33591139 2021
49
Analgesic Comparison of Flunixin Meglumine or Meloxicam for Soft-Tissue Surgery in Sheep: A Pilot Study. 61
33562143 2021
50
Short-term efficacy of epidural pain management in dogs undergoing cystoscopy. 61
33538030 2021

Variations for Pain Agnosia

Expression for Pain Agnosia

Search GEO for disease gene expression data for Pain Agnosia.

Pathways for Pain Agnosia

Pathways related to Pain Agnosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 TAC1 POMC PNOC PENK PDYN OXT
2
Show member pathways
12.72 TRPV1 TAC1 POMC PNOC PENK PDYN
3 12.27 SCN9A POMC OPRM1 CALCA
4
Show member pathways
12.17 POMC PDYN OPRM1 ARRB2
5
Show member pathways
12.11 OXT FOS CALCA ARRB2
6 11.64 POMC OPRM1 FOS
7 11.4 POMC FOS ARRB2
8 10 TAC1 ARRB2

GO Terms for Pain Agnosia

Cellular components related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 TAC1 POMC PNOC PENK PDYN OXT
2 axon GO:0030424 9.85 TAC1 SCN9A PENK OPRM1 CCK CALCA
3 neuron projection GO:0043005 9.8 TRPV1 SCN9A OPRM1 OPRL1 OPRK1 FOS
4 dendrite GO:0030425 9.76 TRPV1 PNOC PENK PDYN OPRM1 OPRK1
5 perikaryon GO:0043204 9.72 PENK OPRM1 OPRK1 NPFF CCK
6 terminal bouton GO:0043195 9.61 OXT CCK CALCA
7 axon terminus GO:0043679 9.35 PNOC PENK PDYN OPRK1 NPFF
8 neuronal cell body GO:0043025 9.23 TRPV1 TAC1 PNOC PENK PDYN OPRK1

Biological processes related to Pain Agnosia according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.28 POMC PNOC PENK OXT OPRM1 OPRL1
2 G protein-coupled receptor signaling pathway GO:0007186 10.13 TAC1 POMC PNOC PENK PDYN OXT
3 inflammatory response GO:0006954 10.04 TRPV1 TAC1 SCN9A FOS CALCA
4 chemical synaptic transmission GO:0007268 9.95 TAC1 PNOC PENK PDYN OPRK1 NPFF
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.93 TRPV1 TAC1 OXT OPRM1 NPFF CALCA
6 response to lipopolysaccharide GO:0032496 9.92 TAC1 PENK OPRM1 FOS
7 response to ethanol GO:0045471 9.87 PENK OPRM1 OPRK1
8 response to estradiol GO:0032355 9.87 PENK OXT OPRL1
9 female pregnancy GO:0007565 9.85 PNOC OXT FOS
10 response to toxic substance GO:0009636 9.85 SCN9A PENK FOS
11 regulation of blood pressure GO:0008217 9.83 TAC1 POMC CALCA
12 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.83 OPRM1 OPRL1 OPRK1
13 excitatory postsynaptic potential GO:0060079 9.83 TRPV1 OPRM1 NPFF ARRB2
14 response to morphine GO:0043278 9.8 TAC1 PENK OPRM1 OPRK1 NPFF
15 response to cocaine GO:0042220 9.79 OXT OPRM1 OPRK1
16 cellular response to nerve growth factor stimulus GO:1990090 9.79 TRPV1 TAC1 CALCA
17 eating behavior GO:0042755 9.77 OXT OPRM1 OPRL1 OPRK1 CCK
18 response to radiation GO:0009314 9.76 PENK OPRM1 OPRK1
19 negative regulation of blood pressure GO:0045776 9.75 OXT OPRL1 CALCA
20 response to pain GO:0048265 9.73 TRPV1 TRPA1 TAC1 CALCA
21 regulation of sensory perception of pain GO:0051930 9.73 OXT OPRM1 OPRL1 OPRK1 NPFF CCK
22 estrous cycle GO:0044849 9.72 OPRM1 OPRL1 OPRK1
23 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.71 TRPV1 CALCA ARRB2
24 negative regulation of cAMP-mediated signaling GO:0043951 9.7 OPRM1 OPRL1
25 positive regulation of ossification GO:0045778 9.69 TAC1 OXT
26 behavior GO:0007610 9.69 OPRL1 OPRK1
27 negative regulation of heart rate GO:0010459 9.69 TRPV1 TAC1 NPFF
28 positive regulation of renal sodium excretion GO:0035815 9.68 TAC1 OXT
29 G protein-coupled receptor internalization GO:0002031 9.68 CALCA ARRB2
30 behavioral response to pain GO:0048266 9.67 TRPV1 SCN9A
31 maternal behavior GO:0042711 9.67 OXT OPRK1
32 sleep GO:0030431 9.67 OXT FOS
33 opioid receptor signaling pathway GO:0038003 9.67 OPRM1 OPRL1 OPRK1
34 negative regulation of appetite GO:0032099 9.66 NPFF CCK
35 positive regulation of behavioral fear response GO:2000987 9.65 PENK CCK
36 positive regulation of sensory perception of pain GO:1904058 9.65 OPRL1 CCK
37 acute inflammatory response to antigenic stimulus GO:0002438 9.64 OPRM1 NPFF
38 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.63 OPRM1 OPRL1
39 sensory perception GO:0007600 9.63 PNOC PENK PDYN OPRM1 OPRL1 OPRK1
40 conditioned place preference GO:1990708 9.61 OPRL1 OPRK1
41 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.6 TRPV1 TRPA1
42 thermoception GO:0050955 9.59 TRPV1 TRPA1
43 positive regulation of gastric acid secretion GO:0060454 9.57 TRPV1 OPRL1
44 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.56 OPRM1 OPRK1
45 sensory perception of pain GO:0019233 9.56 TRPV1 TRPA1 TAC1 SCN9A PENK OPRM1
46 neuropeptide signaling pathway GO:0007218 9.32 TAC1 POMC PNOC PENK PDYN OPRM1

Molecular functions related to Pain Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.67 POMC OXT CCK CALCA
2 G protein-coupled receptor binding GO:0001664 9.61 POMC NPFF ARRB2
3 peptide binding GO:0042277 9.58 OPRM1 OPRL1 OPRK1
4 neuropeptide binding GO:0042923 9.5 OPRM1 OPRL1 OPRK1
5 calcium-release channel activity GO:0015278 9.46 TRPV1 TRPA1
6 opioid receptor activity GO:0004985 9.43 OPRM1 OPRL1 OPRK1
7 opioid receptor binding GO:0031628 9.33 PNOC PENK PDYN
8 opioid peptide activity GO:0001515 9.13 PNOC PENK PDYN
9 neuropeptide hormone activity GO:0005184 9.02 PNOC PENK OXT NPFF CCK

Sources for Pain Agnosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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