MCID: PNC128
MIFTS: 46

Pain - Chronic

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pain - Chronic

MalaCards integrated aliases for Pain - Chronic:

Name: Pain - Chronic 54
Chronic Pain 54 29 43

Classifications:



Summaries for Pain - Chronic

NINDS : 54 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Pain - Chronic, also known as chronic pain, is related to chronic pain requiring intraspinal analgesia and complex regional pain syndrome. An important gene associated with Pain - Chronic is MLYCD (Malonyl-CoA Decarboxylase), and among its related pathways/superpathways are GABAergic synapse and ADP signalling through P2Y purinoceptor 12. The drugs Anexsia and Kadian have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes.

MedlinePlus : 43 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Related Diseases for Pain - Chronic

Diseases in the Paine Syndrome family:

Central Pain Syndrome Pain - Chronic

Diseases related to Pain - Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 chronic pain requiring intraspinal analgesia 12.1
2 complex regional pain syndrome 11.3
3 trigeminal neuralgia 11.3
4 interstitial cystitis 11.2
5 sickle cell disease 11.1
6 ehlers-danlos syndrome 11.1
7 arthritis 11.1
8 reflex sympathetic dystrophy 11.1
9 headache 11.1
10 myofascial pain syndrome 11.1
11 causalgia 11.1
12 pancreatitis 11.0
13 corticosteroid-binding globulin deficiency 10.9
14 melorheostosis 10.9
15 occipital neuralgia 10.9
16 adiposis dolorosa 10.7
17 brachyolmia type 3 10.7
18 amyotrophy, hereditary neuralgic 10.7
19 polycystic kidney disease 1 with or without polycystic liver disease 10.7
20 stiff-person syndrome 10.7
21 cauda equina syndrome 10.7
22 exostosis 10.7
23 pudendal neuralgia 10.7
24 anterior cutaneous nerve entrapment syndrome 10.7
25 malonyl-coa decarboxylase deficiency 10.6
26 paine syndrome 10.6
27 cervical dystonia 10.6
28 dientamoebiasis 10.6
29 inguinal hernia 10.3
30 spinal cord injury 10.2
31 whiplash 10.2
32 osteoarthritis 10.1
33 opiate dependence 10.1
34 alexithymia 10.0
35 opioid abuse 10.0
36 pain agnosia 10.0
37 neuropathy 10.0
38 post-traumatic stress disorder 10.0
39 multiple sclerosis 10.0
40 substance abuse 10.0
41 breast cancer 9.9
42 personality disorder 9.9
43 neuromuscular disease 9.9
44 rheumatoid arthritis 9.9
45 major depressive disorder 9.9
46 human immunodeficiency virus type 1 9.9
47 diabetic neuropathy 9.9
48 algoneurodystrophy 9.9
49 rheumatic disease 9.9
50 herpes zoster 9.9

Graphical network of the top 20 diseases related to Pain - Chronic:



Diseases related to Pain - Chronic

Symptoms & Phenotypes for Pain - Chronic

Drugs & Therapeutics for Pain - Chronic

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Anexsia 18 ACETAMINOPHEN; HYDROCODONE BITARTRATE Mallinckrodt Group August 1996
2
Kadian 18 MORPHINE SULFATE Purepac Pharmaceutical July 1996
3
Onsolis 18 FENTANYL CITRATE BioDelivery Sciences July 2009
4
Quadramet 18 SAMARIUM SM-153 LEXIDRONAM PENTASODIUM DuPont Merck Pharmaceutical Company March 1997
5
UltraJect 18 MORPHINE SULFATE Mallinckrodt Group August 1996

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chronic Neuropathy Following Chemotherapy Active, not recruiting NCT02654691

Search NIH Clinical Center for Pain - Chronic

Genetic Tests for Pain - Chronic

Genetic tests related to Pain - Chronic:

# Genetic test Affiliating Genes
1 Chronic Pain 29

Anatomical Context for Pain - Chronic

MalaCards organs/tissues related to Pain - Chronic:

41
Spinal Cord, Brain, Testes, Cortex, Bone, Skin, Heart

Publications for Pain - Chronic

Articles related to Pain - Chronic:

(show top 50) (show all 2003)
# Title Authors Year
1
Do neuronal microvascular activation and resultant dysfunction in rheumatoid arthritis contribute to chronic pain? ( 30531079 )
2019
2
The impact of emergency department patient-controlled analgesia (PCA) on the incidence of chronic pain following trauma and non-traumatic abdominal pain. ( 30367688 )
2019
3
Proteomics in chronic pain; investigating mechanistic markers of pain. ( 30384947 )
2019
4
Comment on: Should Rheumatology be a core discipline of a chronic pain multi-disciplinary team?: reply. ( 30398668 )
2019
5
Comment on: Should Rheumatology be a core discipline of a chronic pain multi-disciplinary team? ( 30398670 )
2019
6
Effect of an opioid management program for Colorado workers' compensation providers on adherence to treatment guidelines for chronic pain. ( 30499587 )
2019
7
Practicing Patience in the Midst of Chronic Pain. ( 30531499 )
2019
8
Clinician Response to Aberrant Urine Drug Test Results of Patients Prescribed Opioid Therapy for Chronic Pain. ( 30222612 )
2019
9
Proteome-based systems biology in chronic pain. ( 29653266 )
2019
10
Chronic pain and geriatric syndromes in community-dwelling patients aged a8Y65 years. ( 29950889 )
2018
11
Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. ( 29343280 )
2018
12
Physical and psychosocial factors in the prevention of chronic pain in older age. ( 29949780 )
2018
13
Chronic pain in medullary sponge kidney: a rare and never described clinical presentation. ( 29468561 )
2018
14
Longitudinal resting-state fMRI in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )
2018
15
Opiate Dependence or Addiction?: A Review of the Centers for Disease Control and Prevention Guidelines for Management of Chronic Pain. ( 29505462 )
2018
16
Transcranial Direct Current Stimulation as a Therapeutic Tool for Chronic Pain. ( 29952860 )
2018
17
Prioritizing pediatric chronic pain and comprehensive pain treatment in the context of the opioid epidemic. ( 29451426 )
2018
18
Transcutaneous electrical nerve stimulation and interferential current demonstrate similar effects in relieving acute and chronic pain: a systematic review with meta-analysis. ( 29426587 )
2018
19
Identification of FAM173B as a protein methyltransferase promoting chronic pain. ( 29444090 )
2018
20
Computerised training improves cognitive performance in chronic pain: a participant-blinded randomised active-controlled trial with remote supervision. ( 29447133 )
2018
21
Clinimetric properties of the Nepali version of the Pain Catastrophizing Scale in individuals with chronic pain. ( 29430196 )
2018
22
Effects of Higher Versus Lower Threat Contexts on Pain-Related Visual Attention Biases: an Eye-Tracking Study of Chronic Pain. ( 29452312 )
2018
23
Chronic pain, discomfort, quality of life and impact on sex life after open inguinal hernia mesh repair: an expertise-based randomized clinical trial comparing lightweight and heavyweight mesh. ( 29353339 )
2018
24
New Concepts of Chronic Pain and the Potential Role of Complementary Therapies. ( 29428928 )
2018
25
Youth with Chronic Pain and Postural Orthostatic Tachycardia Syndrome (POTS): Treatment Mediators of Improvement in Functional Disability. ( 29508112 )
2018
26
Expanding the role of clinical pharmacists on interdisciplinary primary care teams for chronic pain and opioid management. ( 29970008 )
2018
27
Ziconotide: Indications, Adverse Effects, and Limitations in Managing Refractory Chronic Pain. ( 29440821 )
2018
28
Anterior insular volume decrease is associated with dysfunction of the reward system in patients with chronic pain. ( 29436061 )
2018
29
Protocol for the Individual Placement and Support (IPS) in Pain Trial: A randomized controlled trial investigating the effectiveness of IPS for patients with chronic pain. ( 29433493 )
2018
30
Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome. ( 29416466 )
2018
31
Potentiation of cortical excitatory transmission in chronic pain. ( 29944613 )
2018
32
Depressive Disorder, Anxiety Disorder and Chronic Pain: Multiple Manifestations of a Common Clinical and Pathophysiological Core. ( 29428122 )
2018
33
Seeking virtual social support through blogging: A content analysis of published blog posts written by people with chronic pain. ( 29942635 )
2018
34
A population-based examination of the co-occurrence and functional correlates of chronic pain and generalized anxiety disorder. ( 29703452 )
2018
35
Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers-Danlos syndrome hypermobility-type: a narrative review. ( 29357706 )
2018
36
Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy. ( 29105244 )
2018
37
Case of chronic pain after laparoscopic percutaneous extraperitoneal closure in an adolescent girl with inguinal hernia in which open repair was effective. ( 29956498 )
2018
38
Perceived injustice in chronic pain: an examination through the lens of predictive processing. ( 29451429 )
2018
39
A retrospective study of transcutaneous electrical nerve stimulation for chronic pain following ankylosing spondylitis. ( 29979392 )
2018
40
The impact of a short educational movie on promoting chronic pain health literacy in school: a feasibility study. ( 29436071 )
2018
41
Level of readiness of chronic pain patients to practice active self-care. ( 29956872 )
2018
42
Avoiding Catch-22: validating the PainDETECT in a in a population of patients with chronic pain. ( 29958535 )
2018
43
Characterizing the demographics of chronic pain patients in the state of Maine using the Maine all payer claims database. ( 29954350 )
2018
44
Sleep Disturbances in Chronic Pain: Neurobiology, Assessment, and Treatment in Physical Therapist Practice. ( 29425327 )
2018
45
Attitudes of Irish patients with chronic pain towards medicinal cannabis. ( 29423824 )
2018
46
Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. ( 29191644 )
2018
47
Chronic pain in narcolepsy type 1 and type 2 - an underestimated reality. ( 29923259 )
2018
48
Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. ( 29955555 )
2018
49
Comment on "Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery". ( 29973953 )
2018
50
Barriers to the availability and accessibility of controlled medicines for chronic pain in Africa. ( 29447356 )
2018

Variations for Pain - Chronic

Expression for Pain - Chronic

Search GEO for disease gene expression data for Pain - Chronic.

Pathways for Pain - Chronic

GO Terms for Pain - Chronic

Cellular components related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.62 CACNA1B OPRM1

Biological processes related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion transmembrane transport GO:0070588 8.96 CACNA1B OPRM1
2 locomotory behavior GO:0007626 8.62 CACNA1B OPRM1

Molecular functions related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 8.96 CACNA1B OPRM1
2 voltage-gated calcium channel activity GO:0005245 8.62 CACNA1B OPRM1

Sources for Pain - Chronic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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