MCID: PNC128
MIFTS: 49

Pain - Chronic

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pain - Chronic

MalaCards integrated aliases for Pain - Chronic:

Name: Pain - Chronic 55
Chronic Pain 55 30 6 44

Classifications:



Summaries for Pain - Chronic

NINDS : 55 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Pain - Chronic, also known as chronic pain, is related to trigeminal neuralgia and diabetic neuropathy. An important gene associated with Pain - Chronic is USH2A (Usherin), and among its related pathways/superpathways are Serotonergic synapse and Synaptic vesicle cycle. The drugs Bupivacaine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related phenotype is cardiovascular system.

MedlinePlus : 44 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Related Diseases for Pain - Chronic

Diseases in the Paine Syndrome family:

Central Pain Syndrome Pain - Chronic

Diseases related to Pain - Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 trigeminal neuralgia 31.8 SCN9A SLC6A4
2 diabetic neuropathy 30.0 LEP SCN9A
3 eating disorder 29.4 LEP SLC6A4
4 bulimia nervosa 29.1 LEP SLC6A4
5 chronic pain requiring intraspinal analgesia 12.2
6 complex regional pain syndrome 11.3
7 hidradenitis suppurativa 11.2
8 sickle cell disease 11.2
9 arthritis 11.2
10 ehlers-danlos syndrome 11.1
11 headache 11.1
12 reflex sympathetic dystrophy 11.1
13 causalgia 11.1
14 myofascial pain syndrome 11.1
15 pancreatitis 11.0
16 corticosteroid-binding globulin deficiency 10.9
17 melorheostosis 10.9
18 occipital neuralgia 10.9
19 adiposis dolorosa 10.8
20 brachyolmia type 3 10.8
21 amyotrophy, hereditary neuralgic 10.8
22 polycystic kidney disease 1 with or without polycystic liver disease 10.8
23 stiff-person syndrome 10.8
24 cauda equina syndrome 10.8
25 exostosis 10.8
26 pudendal neuralgia 10.8
27 anterior cutaneous nerve entrapment syndrome 10.8
28 malonyl-coa decarboxylase deficiency 10.6
29 paine syndrome 10.6
30 cervical dystonia 10.6
31 dientamoebiasis 10.6
32 inguinal hernia 10.5
33 spinal cord injury 10.3
34 whiplash 10.3
35 neuropathy 10.3
36 osteoarthritis 10.3
37 pain agnosia 10.2
38 alexithymia 10.2
39 post-traumatic stress disorder 10.2
40 substance abuse 10.2
41 breast cancer 10.1
42 rheumatoid arthritis 10.1
43 opiate dependence 10.1
44 opioid abuse 10.1
45 multiple sclerosis 10.0
46 herpes zoster 10.0
47 acyl-coa dehydrogenase, very long-chain, deficiency of 10.0 CPT2 MLYCD
48 personality disorder 10.0
49 peripheral nervous system disease 10.0
50 premature ejaculation 10.0 LEP SLC6A4

Graphical network of the top 20 diseases related to Pain - Chronic:



Diseases related to Pain - Chronic

Symptoms & Phenotypes for Pain - Chronic

MGI Mouse Phenotypes related to Pain - Chronic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 CACNA1B CPT2 LEP MLYCD SLC6A4

Drugs & Therapeutics for Pain - Chronic

Drugs for Pain - Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 567)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 38396-39-3, 2180-92-9 2474
2
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6740-88-1 3821
3
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Not Applicable 15687-27-1 3672
4
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
5
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22204-53-1 156391 1302
6
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
7
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27262-47-1 92253
8
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
9
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27203-92-5 33741
10
Dinoprostone Approved Phase 4 363-24-6 5280360
11
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 84057-95-4 175805 71273
12
Flurbiprofen Approved, Investigational Phase 4,Not Applicable 5104-49-4 3394
13
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
14
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
15
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
16
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
17
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-56-6 53477758 439302
18
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
19
Capsaicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 404-86-4 1548943
20
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
21
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Not Applicable 50-48-6 2160
22
Perphenazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-39-9 4748
23
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56030-54-7 41693
24
Milnacipran Approved, Investigational Phase 4,Not Applicable 92623-85-3 65833
25
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-41-2 439260
26
Levomilnacipran Approved, Investigational Phase 4,Not Applicable 96847-54-0
27
Tocopherol Approved, Investigational Phase 4,Phase 2 1406-66-2 14986
28
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
29
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
30
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
31
Racepinephrine Approved Phase 4,Phase 3,Not Applicable 329-65-7 838
32
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
33
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 51-43-4 5816
34
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
35
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 466-99-9 5284570
36
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 93-14-1 3516
37
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 437-38-7 3345
38
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 76-42-6 5284603
39
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 465-65-6 5284596
40
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 50-02-2 5743
41
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 1177-87-3
42
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52485-79-7 644073 40400
43
Methadone Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 76-99-3 4095
44
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 64-17-5 702
45
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
46
Amphetamine Approved, Illicit, Investigational Phase 4,Not Applicable 300-62-9 3007 5826
47
Citalopram Approved Phase 4,Not Applicable 59729-33-8 2771
48
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-24-8 5755
49
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 302-25-0
50
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 2519)
# Name Status NCT ID Phase Drugs
1 Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Unknown status NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
2 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
3 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
4 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
5 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
6 Placebo In Chronic Back Pain (Phase 2) Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
7 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
8 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
9 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
10 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
11 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
12 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
13 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold Unknown status NCT02550093 Phase 4 Normal Saline;Oxytocin
14 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
15 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
16 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
17 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
18 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
19 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
20 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
21 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
22 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
23 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
24 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
25 Prolotherapy for the Treatment of Plantar Fasciitis Unknown status NCT01326351 Phase 4
26 Postoperative Pain and Angiotensin II Receptor Antagonists Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
27 Acetaminophen for Chronic Pain in Hysterectomy Completed NCT02086747 Phase 4 Acetaminophen;Isotonic
28 Pharmacokinetic Study of Hydrocodone/APAP in Chronic Pain Patients Completed NCT01517295 Phase 4 Hydrocodone
29 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
30 Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
31 An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY) Completed NCT01811186 Phase 4 Oxycodone/naloxone
32 Dexamethasone and Pain Following Total Knee Arthroplasty Completed NCT02271698 Phase 4 Dexamethasone
33 Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy Completed NCT02653651 Phase 4 Ketamine;Lidocaine;Placebo
34 Chronic Pain After Amputation Completed NCT00006427 Phase 4 Amitriptyline
35 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
36 Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS) Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
37 Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza Completed NCT00640042 Phase 4 morphine sulfate extended release capsules
38 Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients Completed NCT00879996 Phase 4 Methadone;Buprenorphine/naloxone
39 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
40 Milnacipran for Chronic Pain in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
41 A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
42 Imaging Pain Relief in Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
43 Effect of Extended-release Oxymorphone Taking With or Without Food on Cognitive Functioning Completed NCT00930943 Phase 4 Oxymorphone ER (Opana ER)
44 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
45 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine
46 Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain Completed NCT01096147 Phase 4
47 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
48 Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery? Completed NCT02775474 Phase 4 Use of Intraoperative Intravenous Methadone;Use of Intraoperative Intravenous Fentanyl
49 Benefit of Laparoscopic Adhesiolysis in Patients With Chronische Abdominal Pain Completed NCT02839564 Phase 4
50 Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use Completed NCT02977208 Phase 4 Gabapentin

Search NIH Clinical Center for Pain - Chronic

Genetic Tests for Pain - Chronic

Genetic tests related to Pain - Chronic:

# Genetic test Affiliating Genes
1 Chronic Pain 30

Anatomical Context for Pain - Chronic

MalaCards organs/tissues related to Pain - Chronic:

42
Spinal Cord, Brain, Testes, Cortex, Eye, Kidney, Bone

Publications for Pain - Chronic

Articles related to Pain - Chronic:

(show top 50) (show all 4074)
# Title Authors Year
1
Chronic pain is associated with a brain aging biomarker in community-dwelling older adults. ( 31009418 )
2019
2
Alexithymia in individuals with chronic pain and its relation to pain intensity, physical interference, depression, and anxiety: a systematic review and meta-analysis. ( 31009416 )
2019
3
Alexithymia moderates effects of psychotherapeutic treatment expectations on depression outcome in interdisciplinary chronic pain treatment. ( 31010581 )
2019
4
Characterizing Social and Academic Aspects of School Anxiety in Pediatric Chronic Pain. ( 31021887 )
2019
5
Pain Anxiety as a Mechanism Linking Pain Severity and Opioid Misuse and Disability Among Individuals With Chronic Pain. ( 31033671 )
2019
6
The efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial. ( 30985624 )
2019
7
Correlation of anxiety and chronic pain to grade of synovitis in patients with knee osteoarthritis. ( 30946731 )
2019
8
Anxiety sensitivity and opioid misuse among opioid-using adults with chronic pain. ( 30896985 )
2019
9
Gender differences in associations between pain-related anxiety and alcohol use among adults with chronic pain. ( 30864852 )
2019
10
Exploring anxiety sensitivity in the relationship between pain intensity and opioid misuse among opioid-using adults with chronic pain. ( 30771621 )
2019
11
Do neuronal microvascular activation and resultant dysfunction in rheumatoid arthritis contribute to chronic pain? ( 30531079 )
2019
12
Comment on a paper by Leysen et al. entitled "Chronic pain in breast cancer survivors: nociceptive, neuropathic, or central sensitization pain?" ( 31091002 )
2019
13
Opioid-induced constipation in chronic pain: Experience with 180 patients. ( 30855724 )
2019
14
The Co-occurrence of Pediatric Chronic Pain and Depression: A Narrative Review and Conceptualization of Mutual Maintenance. ( 31094934 )
2019
15
Understanding the Relationship Between Spiritual Well-Being and Depression in Chronic Pain Patients: The Mediating Role of Pain Catastrophizing. ( 31103504 )
2019
16
The molecular neurobiology of chronic pain-induced depression. ( 30778732 )
2019
17
Cognitive Biases Toward Pain: Implications for a Neurocognitive Processing Perspective in Chronic Pain and its Interaction With Depression. ( 30499835 )
2019
18
Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers-Danlos syndrome hypermobility-type: a narrative review. ( 29357706 )
2019
19
Repetitive Transcranial Magnetic Stimulation Therapy (rTMS) for Endometriosis Patients with Refractory Pelvic Chronic Pain: A Pilot Study. ( 31013910 )
2019
20
Gout and chronic pain in older adults: a Medicare claims study. ( 30927116 )
2019
21
The IASP classification of chronic pain for ICD-11: chronic secondary headache or orofacial pain. ( 30586072 )
2019
22
Post-surgical chronic pain and quality of life in children operated for congenital heart disease. ( 30869169 )
2019
23
Interdisciplinary Pain Management Improves Pain and Function in Pediatric Patients with Chronic Pain Associated with Joint Hypermobility Syndrome. ( 30010052 )
2019
24
The effect of transversus abdominis plane block on acute and chronic pain after inguinal hernia repair. A randomised controlled trial. ( 30769214 )
2019
25
Chronic pain after reoperation of an inguinal hernia with Lichtenstein or laparoscopic repair following a primary Lichtenstein repair: A nationwide questionnaire study. ( 31064656 )
2019
26
Case of chronic pain after laparoscopic percutaneous extraperitoneal closure in an adolescent girl with inguinal hernia in which open repair was effective. ( 29956498 )
2019
27
The sensory pain of Dante's Inferno - Semantics of chronic pain in patients with narcolepsy. ( 31105895 )
2019
28
Effects of intensity of electroacupuncture on chronic pain in patients with knee osteoarthritis: a randomized controlled trial. ( 31088511 )
2019
29
Clinical meaningfulness of duloxetine's effect in Chinese patients with chronic pain due to osteoarthritis: post hoc analyses of a phase 3 randomized trial. ( 30962729 )
2019
30
The short-term effect of PRP on chronic pain in knee osteoarthritis. ( 30995322 )
2019
31
Additional femoral nerve block analgesia does not reduce the chronic pain after total knee arthroplasty: A retrospective study in patients with knee osteoarthritis. ( 30921213 )
2019
32
Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis. ( 30862648 )
2019
33
Pneumatosis cystoides intestinalis: A rare benign cause of chronic pain and bloating with pneumoperitoneum. ( 30638604 )
2019
34
Acceptance and Commitment Therapy for Chronic Pain: Does Post-traumatic Stress Disorder Influence Treatment Outcomes? ( 30602034 )
2019
35
Spinal Cord Stimulation in Patients With Chronic Pain and Restless Legs Syndrome: A Case Report. ( 30933049 )
2019
36
Spinal and afferent PKC signaling mechanisms that mediate chronic pain in sickle cell disease. ( 31051220 )
2019
37
Chronic pain in adults with sickle cell disease is associated with alterations in functional connectivity of the brain. ( 31107926 )
2019
38
Beta2-Adrenergic Receptor Polymorphisms and Haplotypes Associate With Chronic Pain in Sickle Cell Disease. ( 30837870 )
2019
39
A Qualitative Study of Chronic Pain and Self-Management in Adults with Sickle Cell Disease. ( 30266214 )
2019
40
Pediatric pain screening identifies youth at risk of chronic pain in sickle cell disease. ( 30393948 )
2019
41
An Interdisciplinary Approach to Reducing Opioid Prescriptions to Patients with Chronic Pain in a Spinal Cord Injury Center. ( 30266347 )
2019
42
Comorbidities in the first 2 years after arthroscopic hip surgery: substantial increases in mental health disorders, chronic pain, substance abuse and cardiometabolic conditions. ( 30262452 )
2019
43
Psychological Manifestations and Chronic Pain in Whiplash-Associated Disorder Mechanisms: The Whole Pie, Please. ( 30819055 )
2019
44
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease. ( 29987897 )
2019
45
Associations between pain catastrophizing and clinical characteristics in adults with substance use disorders and co-occurring chronic pain. ( 31021654 )
2019
46
Variables affecting the potential efficacy of PRP in providing chronic pain relief. ( 30613159 )
2019
47
Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. ( 30657865 )
2019
48
Obesity increases the risk of chronic pain development after motor vehicle collision. ( 30507783 )
2019
49
Prevalence of TMD and level of chronic pain in a group of Brazilian adolescents. ( 30735506 )
2019
50
Chronic Pain Mitigation and Opioid Weaning at a Multidisciplinary AIDS Clinic: A Case Report. ( 31086750 )
2019

Variations for Pain - Chronic

ClinVar genetic disease variations for Pain - Chronic:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 USH2A NM_206933.2(USH2A): c.2299delG (p.Glu767Serfs) deletion Pathogenic/Likely pathogenic rs80338903 GRCh37 Chromosome 1, 216420437: 216420437
2 USH2A NM_206933.2(USH2A): c.2299delG (p.Glu767Serfs) deletion Pathogenic/Likely pathogenic rs80338903 GRCh38 Chromosome 1, 216247095: 216247095
3 CPT2 NM_000098.2(CPT2): c.149C> A (p.Pro50His) single nucleotide variant Pathogenic rs28936375 GRCh37 Chromosome 1, 53662764: 53662764
4 CPT2 NM_000098.2(CPT2): c.149C> A (p.Pro50His) single nucleotide variant Pathogenic rs28936375 GRCh38 Chromosome 1, 53197092: 53197092
5 USH2A NM_206933.3(USH2A): c.5003G> T (p.Gly1668Val) single nucleotide variant Uncertain significance GRCh37 Chromosome 1, 216258204: 216258204
6 USH2A NM_206933.3(USH2A): c.5003G> T (p.Gly1668Val) single nucleotide variant Uncertain significance GRCh38 Chromosome 1, 216084862: 216084862
7 MYH8 NM_002472.3(MYH8): c.5743A> G (p.Ile1915Val) single nucleotide variant Uncertain significance GRCh37 Chromosome 17, 10293842: 10293842
8 MYH8 NM_002472.3(MYH8): c.5743A> G (p.Ile1915Val) single nucleotide variant Uncertain significance GRCh38 Chromosome 17, 10390525: 10390525

Expression for Pain - Chronic

Search GEO for disease gene expression data for Pain - Chronic.

Pathways for Pain - Chronic

Pathways related to Pain - Chronic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 CACNA1B SLC6A4
2
Show member pathways
11.07 CACNA1B SLC6A4
3
Show member pathways
11.03 CPT2 LEP MLYCD

GO Terms for Pain - Chronic

Cellular components related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 presynapse GO:0098793 8.62 CACNA1B SLC6A4

Biological processes related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.65 CACNA1B SCN9A SLC6A4
2 lipid metabolic process GO:0006629 9.54 CPT2 LEP MLYCD
3 response to estradiol GO:0032355 9.46 LEP SLC6A4
4 response to toxic substance GO:0009636 9.43 SCN9A SLC6A4
5 positive regulation of cold-induced thermogenesis GO:0120162 9.4 CPT2 LEP
6 circadian rhythm GO:0007623 9.32 LEP SLC6A4
7 response to nutrient GO:0007584 9.26 LEP SLC6A4
8 cellular response to retinoic acid GO:0071300 9.16 LEP SLC6A4
9 regulation of blood pressure GO:0008217 8.96 CACNA1B LEP
10 fatty acid beta-oxidation GO:0006635 8.62 CPT2 LEP

Molecular functions related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 8.96 CACNA1B SCN9A
2 myosin binding GO:0017022 8.62 SLC6A4 USH2A

Sources for Pain - Chronic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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