MCID: PNC128
MIFTS: 46

Pain - Chronic

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pain - Chronic

MalaCards integrated aliases for Pain - Chronic:

Name: Pain - Chronic 55
Chronic Pain 55 30 6 44

Classifications:



Summaries for Pain - Chronic

NINDS : 55 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Pain - Chronic, also known as chronic pain, is related to chronic pain requiring intraspinal analgesia and complex regional pain syndrome. An important gene associated with Pain - Chronic is CPT2 (Carnitine Palmitoyltransferase 2), and among its related pathways/superpathways is AMPK Enzyme Complex Pathway. The drugs Ketamine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, breast and brain.

MedlinePlus : 44 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Related Diseases for Pain - Chronic

Diseases in the Paine Syndrome family:

Central Pain Syndrome Pain - Chronic

Diseases related to Pain - Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 chronic pain requiring intraspinal analgesia 12.2
2 complex regional pain syndrome 11.3
3 trigeminal neuralgia 11.3
4 interstitial cystitis 11.2
5 hidradenitis suppurativa 11.2
6 sickle cell disease 11.2
7 arthritis 11.1
8 ehlers-danlos syndrome 11.1
9 headache 11.1
10 reflex sympathetic dystrophy 11.1
11 myofascial pain syndrome 11.1
12 causalgia 11.1
13 pancreatitis 11.0
14 corticosteroid-binding globulin deficiency 10.9
15 melorheostosis 10.9
16 occipital neuralgia 10.9
17 adiposis dolorosa 10.8
18 brachyolmia type 3 10.8
19 amyotrophy, hereditary neuralgic 10.8
20 polycystic kidney disease 1 with or without polycystic liver disease 10.8
21 stiff-person syndrome 10.8
22 cauda equina syndrome 10.8
23 exostosis 10.8
24 pudendal neuralgia 10.8
25 anterior cutaneous nerve entrapment syndrome 10.8
26 malonyl-coa decarboxylase deficiency 10.6
27 paine syndrome 10.6
28 cervical dystonia 10.6
29 dientamoebiasis 10.6
30 inguinal hernia 10.5
31 spinal cord injury 10.3
32 whiplash 10.3
33 pain agnosia 10.2
34 osteoarthritis 10.2
35 alexithymia 10.2
36 post-traumatic stress disorder 10.2
37 substance abuse 10.2
38 diabetic neuropathy 10.1
39 opiate dependence 10.1
40 breast cancer 10.1
41 rheumatoid arthritis 10.1
42 opioid abuse 10.1
43 multiple sclerosis 10.0
44 herpes zoster 10.0
45 personality disorder 10.0
46 peripheral nervous system disease 10.0
47 rheumatic disease 9.9
48 constipation 9.9
49 migraine with or without aura 1 9.9
50 major depressive disorder 9.9

Graphical network of the top 20 diseases related to Pain - Chronic:



Diseases related to Pain - Chronic

Symptoms & Phenotypes for Pain - Chronic

Drugs & Therapeutics for Pain - Chronic

Drugs for Pain - Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 564)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6740-88-1 3821
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
3
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Not Applicable 15687-27-1 3672
4
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22204-53-1 156391 1302
5
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
6
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
7
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27262-47-1 92253
8
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27203-92-5 33741
9
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
10
Dinoprostone Approved Phase 4 363-24-6 5280360
11
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 84057-95-4 71273 175805
12
Flurbiprofen Approved, Investigational Phase 4,Not Applicable 5104-49-4 3394
13
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
14
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
15
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
16
Levonorgestrel Approved, Investigational Phase 4,Not Applicable 17489-40-6, 797-63-7 13109
17
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-28-2 5757
18
Tibolone Approved, Investigational Phase 4 5630-53-5
19
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Not Applicable 28014-46-2
20
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
21
Palonosetron Approved, Investigational Phase 4 135729-61-2, 119904-90-4, 135729-56-5 148211
22
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
23
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-56-6 439302 53477758
24
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
25
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
26
Capsaicin Approved Phase 4,Phase 3,Phase 2,Not Applicable 404-86-4 1548943
27
Perphenazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-39-9 4748
28
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Not Applicable 50-48-6 2160
29
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56030-54-7 41693
30
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-41-2 439260
31
Levomilnacipran Approved, Investigational Phase 4,Not Applicable 96847-54-0
32
Milnacipran Approved, Investigational Phase 4,Not Applicable 92623-85-3 65833
33
Tocopherol Approved, Investigational Phase 4,Phase 2 1406-66-2 14986
34
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
35
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
36
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
37
Racepinephrine Approved Phase 4,Phase 3,Not Applicable 329-65-7 838
38
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
39
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 51-43-4 5816
40
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
41
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 93-14-1 3516
42
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 466-99-9 5284570
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 437-38-7 3345
44
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 465-65-6 5284596
45
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 76-42-6 5284603
46
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 50-02-2 5743
47
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 1177-87-3
48
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52485-79-7 40400 644073
49
Methadone Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 76-99-3 4095
50
Amphetamine Approved, Illicit, Investigational Phase 4,Not Applicable 300-62-9 3007 5826

Interventional clinical trials:

(show top 50) (show all 2455)
# Name Status NCT ID Phase Drugs
1 Intraoperative Ketamine on Chronic Pain After Mastectomy Unknown status NCT02729805 Phase 4 Saline;Ketamine 0.5mg/kg;Ketamine 0.75mg/kg
2 Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Unknown status NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
3 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
4 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
5 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
6 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
7 Placebo In Chronic Back Pain (Phase 2) Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
8 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
9 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
10 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
11 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
12 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
13 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
14 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
15 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold Unknown status NCT02550093 Phase 4 Normal Saline;Oxytocin
16 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
17 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
18 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
19 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
20 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
21 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
22 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
23 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
24 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
25 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
26 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
27 Prolotherapy for the Treatment of Plantar Fasciitis Unknown status NCT01326351 Phase 4
28 Postoperative Pain and Angiotensin II Receptor Antagonists Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
29 Acetaminophen for Chronic Pain in Hysterectomy Completed NCT02086747 Phase 4 Acetaminophen;Isotonic
30 Pharmacokinetic Study of Hydrocodone/APAP in Chronic Pain Patients Completed NCT01517295 Phase 4 Hydrocodone
31 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
32 Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
33 An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY) Completed NCT01811186 Phase 4 Oxycodone/naloxone
34 Dexamethasone and Pain Following Total Knee Arthroplasty Completed NCT02271698 Phase 4 Dexamethasone
35 Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy Completed NCT02653651 Phase 4 Ketamine;Lidocaine;Placebo
36 Chronic Pain After Amputation Completed NCT00006427 Phase 4 Amitriptyline
37 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
38 Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS) Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
39 Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza Completed NCT00640042 Phase 4 morphine sulfate extended release capsules
40 Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients Completed NCT00879996 Phase 4 Methadone;Buprenorphine/naloxone
41 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
42 Milnacipran for Chronic Pain in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
43 A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
44 Imaging Pain Relief in Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
45 Effect of Extended-release Oxymorphone Taking With or Without Food on Cognitive Functioning Completed NCT00930943 Phase 4 Oxymorphone ER (Opana ER)
46 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
47 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine
48 Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain Completed NCT01096147 Phase 4
49 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
50 Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery? Completed NCT02775474 Phase 4 Use of Intraoperative Intravenous Methadone;Use of Intraoperative Intravenous Fentanyl

Search NIH Clinical Center for Pain - Chronic

Genetic Tests for Pain - Chronic

Genetic tests related to Pain - Chronic:

# Genetic test Affiliating Genes
1 Chronic Pain 30

Anatomical Context for Pain - Chronic

MalaCards organs/tissues related to Pain - Chronic:

42
Spinal Cord, Breast, Brain, Testes, Cortex, Lung, Eye

Publications for Pain - Chronic

Articles related to Pain - Chronic:

(show top 50) (show all 3949)
# Title Authors Year
1
Anxiety sensitivity and opioid misuse among opioid-using adults with chronic pain. ( 30896985 )
2019
2
Gender differences in associations between pain-related anxiety and alcohol use among adults with chronic pain. ( 30864852 )
2019
3
Exploring anxiety sensitivity in the relationship between pain intensity and opioid misuse among opioid-using adults with chronic pain. ( 30771621 )
2019
4
Do neuronal microvascular activation and resultant dysfunction in rheumatoid arthritis contribute to chronic pain? ( 30531079 )
2019
5
Opioid-induced constipation in chronic pain: Experience with 180 patients. ( 30855724 )
2019
6
The molecular neurobiology of chronic pain-induced depression. ( 30778732 )
2019
7
The IASP classification of chronic pain for ICD-11: chronic secondary headache or orofacial pain. ( 30586072 )
2019
8
Post-surgical chronic pain and quality of life in children operated for congenital heart disease. ( 30869169 )
2019
9
Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain. ( 30564910 )
2019
10
The effect of transversus abdominis plane block on acute and chronic pain after inguinal hernia repair. A randomised controlled trial. ( 30769214 )
2019
11
Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis. ( 30862648 )
2019
12
Pneumatosis cystoides intestinalis: A rare benign cause of chronic pain and bloating with pneumoperitoneum. ( 30638604 )
2019
13
Acceptance and Commitment Therapy for Chronic Pain: Does Post-traumatic Stress Disorder Influence Treatment Outcomes? ( 30602034 )
2019
14
Beta2-Adrenergic Receptor Polymorphisms and Haplotypes Associate With Chronic Pain in Sickle Cell Disease. ( 30837870 )
2019
15
Pediatric pain screening identifies youth at risk of chronic pain in sickle cell disease. ( 30393948 )
2019
16
Psychological Manifestations and Chronic Pain in Whiplash-Associated Disorder Mechanisms: The Whole Pie, Please. ( 30819055 )
2019
17
Variables affecting the potential efficacy of PRP in providing chronic pain relief. ( 30613159 )
2019
18
Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. ( 30657865 )
2019
19
Subarachnoid block with continuous TAP catheter analgesia produces less chronic pain and better functional outcome after inguinal hernioplasty: a randomized controlled observer-blinded study. ( 30700617 )
2019
20
Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain. ( 30714733 )
2019
21
The impact of emergency department patient-controlled analgesia (PCA) on the incidence of chronic pain following trauma and non-traumatic abdominal pain. ( 30367688 )
2019
22
Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain. ( 30690169 )
2019
23
Safety Analysis of Dorsal Root Ganglion Stimulation in the Treatment of Chronic Pain. ( 30861617 )
2019
24
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain. ( 30862664 )
2019
25
Could epigenetics help explain racial disparities in chronic pain? ( 30863142 )
2019
26
Chronic pain syndromes: overlapping phenotypes with common mechanisms. ( 30863535 )
2019
27
Physical Therapy Outcome Measures for Assessment of Lower Extremity Chronic Pain-Related Function in Pediatrics. ( 30865142 )
2019
28
Marijuana Use is Not Associated with Changes in Opioid Prescriptions or Pain Severity Among People Living with HIV and Chronic Pain. ( 30865181 )
2019
29
Pain is a Family Matter: Quality of Life in Mothers and Fathers of Youth with Chronic Pain. ( 30866054 )
2019
30
Ultrasound-guided Erector Spinae Plane Block: Indications, Complications, and Effects on Acute and Chronic Pain Based on a Single-center Experience. ( 30868029 )
2019
31
Chronic pain following laparoscopic living-donor nephrectomy: prevalence and impact on quality of life. ( 30868731 )
2019
32
A Replicable and Sustainable Whole Person Care Model for Chronic Pain. ( 30870025 )
2019
33
Review on biomarkers in the resting-state networks of chronic pain patients. ( 30879493 )
2019
34
Corrigendum to Pinning to Cope: Using Pinterest for Chronic Pain Management. ( 30880497 )
2019
35
Qualitative evaluation of an interdisciplinary chronic pain intervention: outcomes and barriers and facilitators to ongoing pain management. ( 30881097 )
2019
36
Who benefits from multimodal rehabilitation - an exploration of pain, psychological distress, and life impacts in over 35,000 chronic pain patients identified in the Swedish Quality Registry for Pain Rehabilitation. ( 30881099 )
2019
37
Can physical activity and exercise alleviate chronic pain in adults? - A Cochrane Review summary with commentary. ( 30882394 )
2019
38
Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back. ( 30883419 )
2019
39
Exploring the Prevalence and Construct Validity of High-Impact Chronic Pain Across Chronic Low-Back Pain Study Samples. ( 30885677 )
2019
40
The Lighten Your Life Program: An Educational Support Group Intervention That Used a Mobile App for Managing Depressive Symptoms and Chronic Pain. ( 30888427 )
2019
41
Opioid cessation and chronic pain: perspectives of former opioid users. ( 30889052 )
2019
42
The behavioural inhibition system, behavioural activation system and experiential avoidance as explanatory variables of comorbid chronic pain and posttraumatic stress symptoms. ( 30891160 )
2019
43
A cross-cultural validation of the Multidimensional Pain Readiness to Change Questionnaire 2 for Japanese individuals with chronic pain. ( 30891879 )
2019
44
Detection of systemic inflammation in severely impaired chronic pain patients and effects of a multimodal pain rehabilitation program. ( 30893060 )
2019
45
The societal costs of chronic pain and its determinants: The case of Austria. ( 30893370 )
2019
46
The Effects of Early Neuropathic Pain Control with Gabapentin on Long-Term Chronic Pain and Itch in Burn Patients. ( 30893433 )
2019
47
Gender Differences in the Prevalence of Chronic Pain and Leisure Time Physical Activity Among US Adults: A NHANES Study. ( 30893869 )
2019
48
Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo. ( 30894274 )
2019
49
Subdissociative Dose Ketamine Is Effective for Treating Acute Exacerbations of Chronic Pain. ( 30901130 )
2019
50
A proposed definition of remission from chronic pain, based on retrospective evaluation of 24-month outcomes with spinal cord stimulation. ( 30901266 )
2019

Variations for Pain - Chronic

ClinVar genetic disease variations for Pain - Chronic:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 USH2A NM_206933.2(USH2A): c.2299delG (p.Glu767Serfs) deletion Pathogenic/Likely pathogenic rs80338903 GRCh37 Chromosome 1, 216420437: 216420437
2 USH2A NM_206933.2(USH2A): c.2299delG (p.Glu767Serfs) deletion Pathogenic/Likely pathogenic rs80338903 GRCh38 Chromosome 1, 216247095: 216247095
3 CPT2 NM_000098.2(CPT2): c.149C> A (p.Pro50His) single nucleotide variant Pathogenic rs28936375 GRCh37 Chromosome 1, 53662764: 53662764
4 CPT2 NM_000098.2(CPT2): c.149C> A (p.Pro50His) single nucleotide variant Pathogenic rs28936375 GRCh38 Chromosome 1, 53197092: 53197092
5 USH2A NM_206933.3(USH2A): c.5003G> T (p.Gly1668Val) single nucleotide variant Uncertain significance GRCh37 Chromosome 1, 216258204: 216258204
6 USH2A NM_206933.3(USH2A): c.5003G> T (p.Gly1668Val) single nucleotide variant Uncertain significance GRCh38 Chromosome 1, 216084862: 216084862
7 MYH8 NM_002472.3(MYH8): c.5743A> G (p.Ile1915Val) single nucleotide variant Uncertain significance GRCh37 Chromosome 17, 10293842: 10293842
8 MYH8 NM_002472.3(MYH8): c.5743A> G (p.Ile1915Val) single nucleotide variant Uncertain significance GRCh38 Chromosome 17, 10390525: 10390525

Expression for Pain - Chronic

Search GEO for disease gene expression data for Pain - Chronic.

Pathways for Pain - Chronic

Pathways related to Pain - Chronic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 CPT2 MLYCD

GO Terms for Pain - Chronic

Biological processes related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 8.96 CPT2 MLYCD
2 regulation of ion transmembrane transport GO:0034765 8.62 CACNA1B SCN9A

Molecular functions related to Pain - Chronic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 8.96 CACNA1B SCN9A
2 voltage-gated ion channel activity GO:0005244 8.62 CACNA1B SCN9A

Sources for Pain - Chronic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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