PAIN
MCID: PNS012
MIFTS: 62

Paine Syndrome (PAIN)

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Paine Syndrome

MalaCards integrated aliases for Paine Syndrome:

Name: Paine Syndrome 57 53 73
Pain Disorder 12 55 15 73
Pain 29 6 43
Microcephaly with Spastic Diplegia 57 53
Pain Syndrome 15

Characteristics:

OMIM:

57
Inheritance:
x-linked


HPO:

32
paine syndrome:
Inheritance x-linked inheritance


Classifications:



External Ids:

OMIM 57 311400
Disease Ontology 12 DOID:0060164
MedGen 42 C1412041
ICD10 33 R52 R52.9

Summaries for Paine Syndrome

MedlinePlus : 43 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen, chest, pelvis, or you may feel pain all over. Pain can be helpful in diagnosing a problem. If you never felt pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. There are two types of pain: acute and chronic. Acute pain usually comes on suddenly, because of a disease, injury, or inflammation. It can often be diagnosed and treated. It usually goes away, though sometimes it can turn into chronic pain. Chronic pain lasts for a long time, and can cause severe problems. Pain is not always curable, but there are many ways to treat it. Treatment depends on the cause and type of pain. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Paine Syndrome, also known as pain disorder, is related to complex regional pain syndrome and familial episodic pain syndrome. An important gene associated with Paine Syndrome is PTPRQ (Protein Tyrosine Phosphatase, Receptor Type Q), and among its related pathways/superpathways are Cardiac conduction and Development Endothelin-1/EDNRA signaling. The drugs Abstral and Actiq have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and brain, and related phenotypes are microcephaly and generalized myoclonic seizures

Disease Ontology : 12 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Description from OMIM: 311400

Related Diseases for Paine Syndrome

Diseases in the Paine Syndrome family:

Central Pain Syndrome Pain - Chronic

Diseases related to Paine Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2636)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 33.9 IL1B SCN9A TAC1
2 familial episodic pain syndrome 33.8 SCN11A TRPA1
3 indifference to pain, congenital, autosomal recessive 33.6 SCN10A SCN11A SCN9A
4 interstitial cystitis 32.8 BDNF NGF TAC1 TRPV1
5 causalgia 32.5 NGF SCN10A SCN11A TAC1
6 diabetic neuropathy 32.1 NGF SCN9A TRPV1
7 peripheral nervous system disease 31.5 NGF SCN9A TAC1 TRPV1
8 hernia, hiatus 31.5 ATP12A ATP4A
9 neuroschistosomiasis 31.4 NGF TAC1
10 prurigo nodularis 31.4 NGF TAC1
11 paroxysmal extreme pain disorder 31.4 SCN10A SCN11A SCN9A TRPV1
12 cystitis 31.3 NGF TAC1 TRPV1
13 lymphocytic colitis 31.3 ATP12A ATP4A
14 superior mesenteric artery syndrome 31.2 ATP12A ATP4A
15 laryngitis 31.1 ATP12A ATP4A IL1B
16 clostridium difficile colitis 31.1 ATP12A ATP4A IL1B
17 esophageal candidiasis 31.0 ATP12A ATP4A
18 toxic megacolon 30.8 ATP12A ATP4A
19 rumination disorder 30.8 ATP12A ATP4A
20 lesion of sciatic nerve 30.7 NGF SCN10A TRPV1
21 polyposis, skin pigmentation, alopecia, and fingernail changes 30.7 ATP12A ATP4A CABIN1
22 jejunoileitis 30.4 ATP12A ATP4A IL1B NGF
23 stomach disease 30.2 ATP12A ATP4A IL1B SCN10A TRPV1
24 neuropathy, hereditary sensory and autonomic, type v 29.8 BDNF NGF
25 esophageal disease 29.8 ATP12A ATP4A TRPV1
26 dyskinesia of esophagus 29.7 ATP12A ATP4A
27 trigeminal neuralgia 29.7 SCN10A SCN9A TRPV1
28 sciatic neuropathy 29.6 NGF SCN10A TRPV1
29 chronic intestinal vascular insufficiency 29.6 ATP12A ATP4A
30 duodenitis 29.6 ATP12A ATP4A
31 bile reflux 29.6 ATP12A ATP4A
32 active peptic ulcer disease 29.5 ATP12A ATP4A
33 erythermalgia, primary 29.5 SCN10A SCN11A SCN9A
34 erythromelalgia 29.4 SCN10A SCN9A
35 burning mouth syndrome 29.4 NGF SCN9A TAC1 TRPV1
36 mononeuropathy 29.4 TAC1 TRPV1
37 migraine with or without aura 1 29.3 TAC1 TRPA1 TRPV1
38 corneal ulcer 29.3 IL1B NGF
39 neuroma 29.3 NGF SCN10A TRPV1
40 gastrointestinal system disease 29.2 ATP12A ATP4A IL1B TRPV1
41 peptic esophagitis 29.2 ATP12A ATP4A IL1B
42 laryngeal tuberculosis 29.1 ATP12A ATP4A
43 cannabis abuse 29.1 BDNF NGF
44 eosinophilic gastritis 29.1 ATP12A ATP4A
45 asthma 29.0 BDNF IL1B NGF TAC1 TRPV1
46 ischemic neuropathy 28.9 ATP12A ATP4A CABIN1 NGF
47 somatoform disorder 28.7 CABIN1 IL1B NGF SCN9A TAC1 TRPA1
48 insensitivity to pain, congenital, with anhidrosis 12.5
49 central pain syndrome 12.4
50 patellofemoral pain syndrome 12.4

Graphical network of the top 20 diseases related to Paine Syndrome:



Diseases related to Paine Syndrome

Symptoms & Phenotypes for Paine Syndrome

Symptoms via clinical synopsis from OMIM:

57
Head:
microcephaly
hypoplasia of cerebellum, inferior olives and pons

Lab:
variable elevated spinal fluid amino acids

Neuro:
spastic diplegia
myoclonic seizures
absent abdominal reflexes


Clinical features from OMIM:

311400

Human phenotypes related to Paine Syndrome:

32
# Description HPO Frequency HPO Source Accession
1 microcephaly 32 HP:0000252
2 generalized myoclonic seizures 32 HP:0002123
3 spastic diplegia 32 HP:0001264
4 olivopontocerebellar hypoplasia 32 HP:0006955

MGI Mouse Phenotypes related to Paine Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 BDNF INPP5D NGF PTPRQ SCN10A SCN11A
2 homeostasis/metabolism MP:0005376 9.96 ATP12A ATP4A BDNF IL1B INPP5D NGF
3 integument MP:0010771 9.85 BDNF IL1B INPP5D NGF SCN10A SCN11A
4 nervous system MP:0003631 9.65 BDNF IL1B NGF P2RX4 PTPRQ SCN10A
5 taste/olfaction MP:0005394 8.92 BDNF SCN9A TRPA1 TRPV1

Drugs & Therapeutics for Paine Syndrome

FDA approved drugs:

(show top 50) (show all 86)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Abstral 18 FENTANYL (citrate) ProStrakan January 2011
2
Actiq 18 FENTANYL (citrate) Anesta Corporation November 1998
3
Anexsia 18 ACETAMINOPHEN; HYDROCODONE BITARTRATE Mallinckrodt Group August 1996
4
Aredia 18 49 PAMIDRONATE DISODIUM Chiron August 1996
5
Arimidex 18 49 ANASTROZOLE AstraZeneca January 1996
6
Bosulif 18 49 BOSUTINIB MONOHYDRATE Pfizer September 2012
7
Bromfenac 18 BROMFENAC SODIUM Duract, Wyeth-Ayerst Laboratories July 1997
8
Campath 18 49 ALEMTUZUMAB Berlex Laboratories May 2001
9
Cometriq 18 49 CABOZANTINIB S-MALATE Exelixis November 2012
10
Degarelix 18 49 degarelix Ferring Pharmaceuticals December of 2008
11
Elitek 18 49 RASBURICASE sanofi-aventis October 2009
12
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
13
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
14
Femara 18 49 LETROZOLE Novartis January 2001
15
Gleevec 18 49 IMATINIB MESYLATE Novartis May 2001
16
Gliadel Wafer 18 49 CARMUSTINE Rhone-Poulenc Rorer, Guilford Pharmaceuticals February 1997
17
Iclusig 18 49 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
18
Imbruvica 18 49 IBRUTINIB Pharmacyclics November of 2013/February 2014
19
Ixempra 18 49 IXABEPILONE Bristol-Myers Squibb October 2007
20
Jevtana 18 49 CABAZITAXEL sanofi aventis June 2010
21
Kadcyla 18 49 ADO-TRASTUZUMAB EMTANSINE Genentech February 2013
22
Kadian 18 MORPHINE SULFATE Purepac Pharmaceutical July 1996
23
Kytril 18 GRANISETRON HYDROCHLORIDE Roche/SmithKline Beecham June 2001/ November 1997
24
Lazanda 18 FENTANYL CITRATE Archimedes June 2011
25
Lenvima 18 49 LENVATINIB MESYLATE Eisai February 2015
26
Lupron Depot 18 49 LEUPROLIDE ACETATE TAP Pharmaceuticals/ Abbott Laboratories July 1997/ January 1996
27
Lynparza 18 49 OLAPARIB AstraZeneca December 2014
28
Neulasta 18 PEGFILGRASTIM Amgen January 2002
29
Neutroval 18 tbo-filgrastim Teva Pharmaceutical August 2012
30
Nolvadex 18 49 TAMOXIFEN CITRATE AstraZeneca October 1998
31
Odomzo 18 49 SONIDEGIB PHOSPHATE Novartis Jul-15
32
Onsolis 18 FENTANYL CITRATE BioDelivery Sciences July 2009
33
Picato gel 18 INGENOL MEBUTATE LEO Pharma January 2012
34
Plenaxis 18 ABARELIX Praecis Pharmaceuticals December 2003
35
Pomalyst 18 49 POMALIDOMIDE Celgene February 2013
36
Premarin 18 ESTROGENS CONJUGATED Wyeth July of 2003
37
Provenge 18 49 sipuleucel-T Dendreon May 2010
38
Quadramet 18 SAMARIUM SM-153 LEXIDRONAM PENTASODIUM DuPont Merck Pharmaceutical Company March 1997
39
Sancuso 18 GRANISETRON ProStrakan September 2008
40
Sclerosol Intrapleural Aerosol 18 49 TALC Bryan Corporation January 1998
41
Stivarga 18 49 REGORAFENIB Bayer/ Bayer HealthCare Pharmaceuticals February 2013/ September 2012
42
Subsys 18 FENTANYL Insys Therapeutics January of 2012
43
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006
44
Synercid I.V. 18 DALFOPRISTIN; QUINUPRISTIN QUINUPRISTIN; DALFOPRISTIN Rhone Poulenc Rorer September 1999
45
Taxol 18 49 PACLITAXEL Bristol-Myers Squibb August 1997
46
Trelstar Depot/ Trelstar LA 18 TRIPTORELIN PAMOATE Debio Rechereche Pharmaceutique, Target Research Associates/ Debiopharm June 2000/ June 2001
47
Trisenox 18 49 ARSENIC TRIOXIDE Cell Therapeutics September 2000
48
UltraJect 18 MORPHINE SULFATE Mallinckrodt Group August 1996
49
Unituxin 18 49 DINUTUXIMAB United Therapeutics March 2015
50
Vandetanib 18 49 vandetanib AstraZeneca April 2011

Search Clinical Trials , NIH Clinical Center for Paine Syndrome

Genetic Tests for Paine Syndrome

Genetic tests related to Paine Syndrome:

# Genetic test Affiliating Genes
1 Pain 29

Anatomical Context for Paine Syndrome

MalaCards organs/tissues related to Paine Syndrome:

41
Prostate, Spinal Cord, Brain, Testes, Bone, Cortex, Skeletal Muscle

Publications for Paine Syndrome

Articles related to Paine Syndrome:

(show top 50) (show all 149)
# Title Authors Year
1
Persistent Dentoalveolar Pain Disorder: A Comprehensive Review. ( 29174443 )
2018
2
Comparison of pain, disorder, back performance, and psychological factors in patients with low back pain and radicular pain. ( 29410582 )
2018
3
Bee Stings and Chronic Pain Disorder. ( 29545983 )
2018
4
Processing of Emotional Faces in Patients with Chronic Pain Disorder: An Eye-Tracking Study. ( 29556205 )
2018
5
Cortical Thickness Alterations in Chronic Pain Disorder: An Exploratory MRI Study. ( 29787468 )
2018
6
The Effectiveness of High-frequency Repetitive Transcranial Magnetic Stimulation in Persistent Somatoform Pain Disorder: A Case Series. ( 30083490 )
2018
7
Development and preliminary evaluation of a new screening instrument for atypical odontalgia and persistent dentoalveolar pain disorder. ( 30229950 )
2018
8
Granulocyte-macrophage colony-stimulating factor receptor expression in clinical pain disorder tissues and role in neuronal sensitization. ( 30534627 )
2018
9
Clinical study of duloxetine hydrochloride combined with doxazosin for the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome: An observational study. ( 28272220 )
2017
10
Altered resting-state intra- and inter- network functional connectivity in patients with persistent somatoform pain disorder. ( 28453543 )
2017
11
The Fear-avoidance Components Scale (FACS): Responsiveness to Functional Restoration Treatment in a Chronic Musculoskeletal Pain Disorder (CMPD) Population. ( 28328697 )
2017
12
Decreased prefrontal brain activation during verbal fluency task in patients with somatoform pain disorder: An exploratory multi-channel near-infrared spectroscopy study. ( 28499896 )
2017
13
Somatoform Pain Disorder Presenting as "Atypical Facial Pain:" A Rare Presentation in a 13-year-old. ( 28852247 )
2017
14
Use of the Central Sensitization Inventory (CSI) as a treatment outcome measure for patients with chronic spinal pain disorder in a functional restoration program. ( 28619687 )
2017
15
Insecure attachment style and cumulative traumatic life events in patients with somatoform pain disorder: A cross-sectional study. ( 29167050 )
2017
16
Parental Protectiveness Mediates the Association between Parent-Perceived Child Self-Efficacy and Health Outcomes in Pediatric Functional Abdominal Pain Disorder. ( 27657151 )
2016
17
Low Level Laser Therapy Versus Pharmacotherapy in Improving Myofascial Pain Disorder Syndrome. ( 27330698 )
2016
18
Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder. ( 27525141 )
2016
19
Psychophysiological decoupling in alexithymic pain disorder patients. ( 26804974 )
2016
20
Altered Spontaneous Activity in Patients with Persistent Somatoform Pain Disorder Revealed by Regional Homogeneity. ( 26977802 )
2016
21
Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study. ( 27641732 )
2016
22
What are the treatment options for paroxysmal extreme pain disorder? ( 26059255 )
2015
23
Amplified Brain Processing of Dentoalveolar Pressure Stimulus in Persistent Dentoalveolar Pain Disorder Patients. ( 26485382 )
2015
24
Effects of Kamishoyosan, a Traditional Japanese Kampo Medicine, on Pain Conditions in Patients with Intractable Persistent Dentoalveolar Pain Disorder. ( 26495024 )
2015
25
Psychogenic Pain Disorder--Differential Diagnosis and Treatment. ( 26529858 )
2015
26
Hypnotherapy of a pain disorder: a clinical case study. ( 25719524 )
2015
27
Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder. ( 25903274 )
2015
28
Prevalence of restless legs syndrome in somatoform pain disorder and its effect on quality of life. ( 25883472 )
2015
29
Bilateral congenital corneal anesthesia in a patient with SCN9A mutation, confirmed primary erythromelalgia, and paroxysmal extreme pain disorder. ( 26486037 )
2015
30
Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study. ( 26129835 )
2015
31
Painful micturition in a small child: an unusual clinical picture of paroxysmal extreme pain disorder. ( 24817410 )
2014
32
p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder. ( 25285947 )
2014
33
Healthcare pathway and biopsychosocial impact of persistent dentoalveolar pain disorder: a qualitative study. ( 24697333 )
2014
34
Pain as a late emotional reaction. Clinical research evaluating the psychosocial expression of pain disorder in preoperative and postoperative period. ( 25341289 )
2014
35
Self-management is key to fibromyalgia treatment. Treating this common chronic pain disorder has baffled patients and physicians for years. ( 25029737 )
2014
36
An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder. ( 23893323 )
2014
37
A comparison of schemas, schema modes and childhood traumas in obsessive-compulsive disorder, chronic pain disorder and eating disorders. ( 23689753 )
2014
38
Factors influencing quality of life in Chinese patients with persistent somatoform pain disorder. ( 24428222 )
2014
39
Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: a preliminary resting-state fMRI study. ( 24439113 )
2014
40
Facial affect perception and mentalizing abilities in female patients with persistent somatoform pain disorder. ( 24395204 )
2014
41
The trade-off between costs and quality of care in the treatment of psychosomatic patients with somatoform pain disorder. ( 23852985 )
2013
42
Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study. ( 22894821 )
2013
43
Effectiveness of a Multimodal Treatment Program for Somatoform Pain Disorder. ( 24305036 )
2013
44
Frequency shifts in the anterior default mode network and the salience network in chronic pain disorder. ( 23497482 )
2013
45
Neural correlates of deficits in pain-related affective meaning construction in patients with chronic pain disorder. ( 23362496 )
2013
46
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. ( 23909967 )
2013
47
Paroxysmal extreme pain disorder. ( 23599527 )
2013
48
Distinctive neural responses to pain stimuli during induced sadness in patients with somatoform pain disorder: An fMRI study. ( 24179828 )
2013
49
Alexithymic and somatisation scores in patients with temporomandibular pain disorder correlate with deficits in facial emotion recognition. ( 23137311 )
2013
50
Predicting return to work following treatment of chronic pain disorder. ( 23503298 )
2013

Variations for Paine Syndrome

ClinVar genetic disease variations for Paine Syndrome:

6 (show all 16)
# Gene Variation Type Significance SNP ID Assembly Location
1 KIF1B NM_015074.3(KIF1B): c.2473G> A (p.Glu825Lys) single nucleotide variant Uncertain significance rs763122049 GRCh37 Chromosome 1, 10384889: 10384889
2 KIF1B NM_015074.3(KIF1B): c.2473G> A (p.Glu825Lys) single nucleotide variant Uncertain significance rs763122049 GRCh38 Chromosome 1, 10324831: 10324831
3 SELENON NM_020451.2(SELENON): c.482G> A (p.Arg161Gln) single nucleotide variant Uncertain significance rs765749301 GRCh38 Chromosome 1, 25805220: 25805220
4 SELENON NM_020451.2(SELENON): c.482G> A (p.Arg161Gln) single nucleotide variant Uncertain significance rs765749301 GRCh37 Chromosome 1, 26131711: 26131711
5 OAT NM_000274.3(OAT): c.875A> G (p.Lys292Arg) single nucleotide variant Likely pathogenic rs1057518927 GRCh38 Chromosome 10, 124402952: 124402952
6 OAT NM_000274.3(OAT): c.875A> G (p.Lys292Arg) single nucleotide variant Likely pathogenic rs1057518927 GRCh37 Chromosome 10, 126091521: 126091521
7 SCN4A NM_000334.4(SCN4A): c.1333G> T (p.Val445Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs121908552 GRCh37 Chromosome 17, 62041947: 62041947
8 SCN4A NM_000334.4(SCN4A): c.1333G> T (p.Val445Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs121908552 GRCh38 Chromosome 17, 63964587: 63964587
9 GJB1 NM_001097642.2(GJB1): c.109G> T (p.Val37Leu) single nucleotide variant Likely pathogenic rs1057518946 GRCh37 Chromosome X, 70443666: 70443666
10 GJB1 NM_001097642.2(GJB1): c.109G> T (p.Val37Leu) single nucleotide variant Likely pathogenic rs1057518946 GRCh38 Chromosome X, 71223816: 71223816
11 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic GRCh37 Chromosome 9, 137593133: 137593133
12 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic GRCh38 Chromosome 9, 134701287: 134701287
13 PTPRQ NM_001145026.1(PTPRQ): c.6475C> T (p.Arg2159Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 12, 81064144: 81064144
14 PTPRQ NM_001145026.1(PTPRQ): c.6475C> T (p.Arg2159Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 12, 80670365: 80670365
15 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 4102388: 4102388
16 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 4102390: 4102390

Expression for Paine Syndrome

Search GEO for disease gene expression data for Paine Syndrome.

Pathways for Paine Syndrome

Pathways related to Paine Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 ATP12A ATP4A SCN10A SCN11A SCN9A
2
Show member pathways
12.35 IL1B NGF TRPA1 TRPV1
3
Show member pathways
12.25 BDNF SCN10A SCN11A SCN9A TAC1
4
Show member pathways
12.2 ATP12A ATP4A TRPA1 TRPV1
5 11.89 NGF P2RX4 SCN10A SCN11A SCN9A
6
Show member pathways
11.71 SCN10A SCN11A SCN9A
7 11.67 BDNF IL1B NGF TAC1
8
Show member pathways
11.37 SCN10A SCN11A SCN9A
9 10.88 TRPA1 TRPV1
10 10.28 SCN10A SCN11A SCN9A

GO Terms for Paine Syndrome

Cellular components related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.17 BDNF NGF P2RX4 SCN10A SCN11A SCN9A
2 stereocilium bundle GO:0032421 9.16 PTPRQ TRPA1
3 voltage-gated sodium channel complex GO:0001518 9.13 SCN10A SCN11A SCN9A

Biological processes related to Paine Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.97 SCN10A SCN11A SCN9A TRPA1 TRPV1
2 inflammatory response GO:0006954 9.94 IL1B SCN9A TAC1 TRPV1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 IL1B TAC1 TRPV1
4 ion transmembrane transport GO:0034220 9.83 P2RX4 SCN10A SCN9A TRPA1 TRPV1
5 regulation of ion transmembrane transport GO:0034765 9.82 SCN10A SCN11A SCN9A
6 calcium ion transmembrane transport GO:0070588 9.8 P2RX4 TRPA1 TRPV1
7 memory GO:0007613 9.73 BDNF IL1B NGF
8 sodium ion transmembrane transport GO:0035725 9.72 SCN10A SCN11A SCN9A
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 IL1B P2RX4 TRPV1
10 peripheral nervous system development GO:0007422 9.66 BDNF NGF
11 regulation of neuron differentiation GO:0045664 9.65 BDNF NGF
12 sodium ion transport GO:0006814 9.65 ATP12A ATP4A SCN10A SCN11A SCN9A
13 regulation of cardiac muscle contraction GO:0055117 9.64 P2RX4 SCN10A
14 neurotrophin TRK receptor signaling pathway GO:0048011 9.63 BDNF NGF
15 response to ATP GO:0033198 9.62 IL1B P2RX4
16 cellular response to ATP GO:0071318 9.62 P2RX4 TRPV1
17 cellular sodium ion homeostasis GO:0006883 9.61 ATP12A ATP4A
18 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.61 ATP12A ATP4A
19 nerve development GO:0021675 9.6 BDNF NGF
20 cellular potassium ion homeostasis GO:0030007 9.59 ATP12A ATP4A
21 sodium ion export across plasma membrane GO:0036376 9.58 ATP12A ATP4A
22 nerve growth factor signaling pathway GO:0038180 9.58 BDNF NGF
23 response to pain GO:0048265 9.58 TAC1 TRPA1 TRPV1
24 ion transport GO:0006811 9.56 ATP12A ATP4A P2RX4 SCN10A SCN11A SCN9A
25 positive regulation of collateral sprouting GO:0048672 9.54 BDNF NGF
26 membrane depolarization during action potential GO:0086010 9.54 SCN10A SCN11A SCN9A
27 positive regulation of prostaglandin secretion GO:0032308 9.52 IL1B P2RX4
28 behavioral response to pain GO:0048266 9.5 P2RX4 SCN9A TRPV1
29 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.49 TRPA1 TRPV1
30 fever generation GO:0001660 9.48 IL1B TRPV1
31 thermoception GO:0050955 9.46 TRPA1 TRPV1
32 neuronal action potential GO:0019228 9.46 P2RX4 SCN10A SCN11A SCN9A
33 sensory perception of pain GO:0019233 9.1 P2RX4 SCN10A SCN9A TAC1 TRPA1 TRPV1

Molecular functions related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.58 SCN10A SCN11A SCN9A
2 calcium-release channel activity GO:0015278 9.37 TRPA1 TRPV1
3 sodium channel activity GO:0005272 9.33 SCN10A SCN11A SCN9A
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP12A ATP4A
5 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP12A ATP4A
6 voltage-gated sodium channel activity GO:0005248 9.13 SCN10A SCN11A SCN9A
7 ion channel activity GO:0005216 9.02 P2RX4 SCN10A SCN11A SCN9A TRPV1

Sources for Paine Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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