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MCID: PNS012
MIFTS: 62

Paine Syndrome

Categories: Rare diseases, Mental diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Paine Syndrome

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MalaCards integrated aliases for Paine Syndrome:

Name: Paine Syndrome 57 53 73
Pain Disorder 12 55 15 73
Pain 29 6 43
Microcephaly with Spastic Diplegia 57 53

Characteristics:

OMIM:

57
Inheritance:
x-linked


HPO:

32
paine syndrome:
Inheritance x-linked inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 311400
Disease Ontology 12 DOID:0060164
MedGen 42 C1412041
ICD10 33 R52 R52.9
Sources

Summaries for Paine Syndrome

About this section
MedlinePlus : 43 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen, chest, pelvis, or you may feel pain all over Pain can be helpful in diagnosing a problem. If you never felt pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. There are two types of pain: acute and chronic. Acute pain usually comes on suddenly, because of a disease, injury, or inflammation. It can often be diagnosed and treated. It usually goes away, though sometimes it can turn into chronic pain. Chronic pain lasts for a long time, and can cause severe problems. Pain is not always curable, but there are many ways to treat it. Treatment depends on the cause and type of pain. Pain relievers and other medicines, acupuncture, physical therapy, and sometimes surgery may be helpful. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Paine Syndrome, also known as pain disorder, is related to familial episodic pain syndrome and complex regional pain syndrome. An important gene associated with Paine Syndrome is PTPRQ (Protein Tyrosine Phosphatase, Receptor Type Q), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Acetaminophen and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and brain, and related phenotypes are microcephaly and spastic diplegia

Disease Ontology : 12 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

Description from OMIM: 311400
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Related Diseases for Paine Syndrome

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Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Paine Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 familial episodic pain syndrome 34.0 SCN11A TRPA1
2 complex regional pain syndrome 33.8 IL1B SCN9A TAC1
3 interstitial cystitis 32.5 NGF TAC1 TRPV1 UPK3A
4 peripheral nervous system disease 32.0 NGF SCN9A TRPV1
5 autonomic nervous system disease 31.1 NGF TAC1
6 paroxysmal extreme pain disorder 30.8 SCN10A SCN11A SCN9A TRPV1
7 cystitis 30.5 NGF TAC1 TRPV1 UPK3A
8 mononeuropathy 29.8 TAC1 TRPV1
9 chronic cystitis 29.8 NGF UPK3A
10 trigeminal neuralgia 29.6 SCN10A SCN9A TRPV1
11 erythermalgia, primary 29.3 SCN10A SCN11A SCN9A
12 erythromelalgia 29.2 SCN10A SCN9A
13 neuroma 29.2 NGF SCN10A TRPV1
14 laryngitis 28.8 ATP12A ATP4A IL1B
15 somatoform disorder 27.7 CABIN1 IL1B NGF SCN9A TAC1 TRPA1
16 central pain syndrome 12.2
17 patellofemoral pain syndrome 12.2
18 myofascial pain syndrome 12.2
19 episodic pain syndrome, familial, 3 12.1
20 episodic pain syndrome, familial, 1 12.1
21 episodic pain syndrome, familial, 2 12.1
22 reflex sympathetic dystrophy 11.7
23 causalgia 11.6
24 fibromyalgia 11.4
25 prostatitis 11.1
26 algoneurodystrophy 10.9
27 thoracic outlet syndrome 10.8
28 glossopharyngeal neuralgia 10.8
29 cough variant asthma 10.8 NGF TRPV1
30 neuroschistosomiasis 10.8 NGF TAC1
31 corneal neuropathic disease 10.8
32 prurigo nodularis 10.7 NGF TAC1
33 diabetic neuropathy 10.5 NGF SCN9A TRPV1
34 fungal esophagitis 10.5 ATP12A ATP4A
35 bladder calculus 10.5 ATP12A ATP4A
36 gastrointestinal neuroendocrine benign tumor 10.5 ATP12A ATP4A
37 neonatal candidiasis 10.5 ATP12A ATP4A
38 photoallergic dermatitis 10.4 ATP12A ATP4A
39 squamous papillomatosis 10.4 ATP12A ATP4A
40 calciphylaxis 10.4
41 trochleitis 10.4
42 acute laryngitis 10.4 ATP12A ATP4A
43 gastroduodenal crohn's disease 10.4 ATP12A ATP4A
44 gastric neuroendocrine neoplasm 10.4 ATP12A ATP4A
45 toxic megacolon 10.4 ATP12A ATP4A
46 aspiration pneumonitis 10.4 ATP12A ATP4A
47 mononeuritis of lower limb 10.4 SCN10A TRPV1
48 postsurgical hypothyroidism 10.4 ATP12A ATP4A
49 gastric antral vascular ectasia 10.4 ATP12A ATP4A
50 esophageal candidiasis 10.4 ATP12A ATP4A

Graphical network of the top 20 diseases related to Paine Syndrome:



Diseases related to Paine Syndrome
Sources

Symptoms & Phenotypes for Paine Syndrome

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Symptoms via clinical synopsis from OMIM:

57
Head:
microcephaly
hypoplasia of cerebellum, inferior olives and pons

Lab:
variable elevated spinal fluid amino acids

Neuro:
spastic diplegia
myoclonic seizures
absent abdominal reflexes


Clinical features from OMIM:

311400

Human phenotypes related to Paine Syndrome:

32
# Description HPO Frequency HPO Source Accession
1 microcephaly 32 HP:0000252
2 spastic diplegia 32 HP:0001264
3 generalized myoclonic seizures 32 HP:0002123
4 olivopontocerebellar hypoplasia 32 HP:0006955

MGI Mouse Phenotypes related to Paine Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 INPP5D NGF PTPRQ SCN10A SCN11A SCN9A
2 integument MP:0010771 9.61 IL1B INPP5D NGF SCN10A SCN11A SCN9A
3 taste/olfaction MP:0005394 8.8 SCN9A TRPA1 TRPV1
Sources

Drugs & Therapeutics for Paine Syndrome

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Drugs for Paine Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 495)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 103-90-2 1983
2
Dinoprostone Approved Phase 4 363-24-6 5280360
3
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
4
Gabapentin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 60142-96-3 3446
5
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 75614-87-8, 51-45-6 774
6
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
7
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
8
Milnacipran Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 92623-85-3 65833
9
Etoricoxib Approved, Investigational Phase 4,Phase 2 202409-33-4 123619
10
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-48-6 2160
11
Cyclobenzaprine Approved Phase 4,Phase 3,Phase 2,Not Applicable 303-53-7 2895
12
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
13
Ropivacaine Approved Phase 4,Phase 3,Not Applicable 84057-95-4 71273 175805
14
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 51-84-3 187
15
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
16
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 124-94-7 31307
17
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
18
Norepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-41-2 439260
19
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2216-51-5 16666
20
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
21
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-39-9 4748
22
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9004-61-9 53477741
23
Cycloserine Approved Phase 4 68-41-7 401 6234
24
Colchicine Approved Phase 4 64-86-8 6167 2833
25
Cortisone acetate Approved, Investigational Phase 4,Phase 3,Not Applicable 1950-04-4, 50-04-4 5745
26
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
27
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
28
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
29
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-12-2 119
30
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
32
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
33
Remifentanil Approved Phase 4 132875-61-7 60815
34
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
35
Armodafinil Approved, Investigational Phase 4 112111-43-0
36
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
37
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2 54910-89-3 3386
38
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
39
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
40
Paroxetine Approved, Investigational Phase 4,Phase 1,Phase 2 61869-08-7 43815
41
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
42
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 378-44-9 9782
43
Naltrexone Approved, Investigational, Vet_approved Phase 4,Not Applicable 16590-41-3 5360515
44
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 76-42-6 5284603
45
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
46
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 52485-79-7 40400 644073
47
Naloxone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 465-65-6 5284596
48
Methyltestosterone Approved Phase 4,Phase 2 58-18-4 6010
49
Testosterone Approved, Investigational Phase 4,Phase 2 58-22-0 6013
50
Testosterone enanthate Approved Phase 4,Phase 2 315-37-7 9416

Interventional clinical trials:

(show top 50) (show all 1237)
# Name Status NCT ID Phase Drugs
1 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
2 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
3 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
4 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran
5 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4 etoricoxib
6 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
7 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
8 Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy. Completed NCT01250184 Phase 4 Lidocaine injection
9 EMINEM: Efficacy of Muscoril In NEck Myofascial Syndromes Completed NCT00272532 Phase 4 Thiocolchicoside
10 Cortisone Injection vs Trigger Point Dry Needling Fin the Treatment of Greater Trochanter Pain Syndrome: A Pilot Study Completed NCT02639039 Phase 4 Cortisone Injection
11 Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks Completed NCT02619513 Phase 4 Dexmedetomidine;Ropivacaine
12 Lansoprazole Versus Mosapride for Functional Dyspepsia Completed NCT00663897 Phase 4 lansoprazole;mosapride
13 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
14 Pregabalin and Post-thoracotomy Pain Completed NCT00663962 Phase 4 Pregabalin;Placebo
15 Comprehensive Cardiothoracic Dual Source CT for the Early Triage of Patients With Acute Chest Pain Completed NCT01067456 Phase 4
16 Restore Claims Characterization Study Completed NCT00200122 Phase 4
17 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
18 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
19 Glucomannan for the Treatment of Abdominal Pain-related Functional Gastrointestinal Disorders in Childhood Completed NCT01495806 Phase 4 Glucomannan;placebo
20 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
21 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
22 Efficacy of Gabapentin in the Treatment of Chest Pain and Paresthesia in Patients With Sternotomy Completed NCT00800527 Phase 4 Gabapentin;Diclofenac
23 The Efficacy and Safety of Qizhiweitong Granule on Patients With Functional Dyspepsia in a Multi-center Clinical Study Completed NCT02460601 Phase 4 Qizhiweitong granule
24 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
25 Intranasal Oxytocin for the Treatment of Pain Associated With Interstitial Cystitis Completed NCT00919802 Phase 4 Oxytocin
26 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
27 Imaging Pain Relief in Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
28 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed NCT01195116 Phase 4 Dexmedetomidine;Normal Saline
29 Treatment of Chronic Bacterial Prostatitis Completed NCT02130713 Phase 4 Third generation fluoroquinolone
30 Discomfort and Psychosocial Difficulties in Fibromyalgia Completed NCT02078791 Phase 4 Botox infiltration
31 Strengthening Exercises for Fibromyalgia Completed NCT02063750 Phase 4
32 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
33 Quetiapine Compared With Placebo in the Management of Fibromyalgia Completed NCT01458964 Phase 4 Quetiapine
34 Effect of Milnacipran on Pain in Fibromyalgia Completed NCT01288807 Phase 4 Milnacipram
35 Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia Completed NCT01226667 Phase 4 Pregabalin
36 A Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional MRI in Patients With Fibromyalgia Completed NCT01173055 Phase 4 milnacipran;Placebo
37 Study of Milnacipran in Patients With Inadequate Response to Duloxetine for the Treatment of Fibromyalgia Completed NCT01077375 Phase 4 Placebo;Milnacipran
38 Drug and Talk Therapy for Fibromyalgia Completed NCT01038323 Phase 4 Educational with milnacipran
39 Pregabalin In Adolescent Patients With Fibromyalgia Completed NCT01020526 Phase 4 pregabalin
40 Adolescent Fibromyalgia Study Completed NCT01020474 Phase 4 placebo;pregabalin (Lyrica)
41 Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia Completed NCT01014585 Phase 4 Placebo;Milnacipran
42 Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study Completed NCT00983320 Phase 4 quetiapine;placebo
43 A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia Completed NCT00965601 Phase 4
44 A Study for Adult Patients With Fibromyalgia Completed NCT00965081 Phase 4 Duloxetine;Placebo
45 Trazodone and Its Augmentation With Pregabalin in the Treatment of Fibromyalgia Completed NCT00791739 Phase 4 trazodone, pregabalin
46 An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain Completed NCT00766675 Phase 4 Tramadol hydrochloride;Acetaminophen
47 Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia Completed NCT00766350 Phase 4 amitriptyline;quetiapine
48 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
49 A Study Comparing Duloxetine and Placebo in the Treatment of Fibromyalgia Completed NCT00673452 Phase 4 duloxetine hydrochloride;placebo
50 Ai Chi Versus Stretching in Fibromyalgia Management Completed NCT00600574 Phase 4

Search NIH Clinical Center for Paine Syndrome

Sources

Genetic Tests for Paine Syndrome

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Genetic tests related to Paine Syndrome:

# Genetic test Affiliating Genes
1 Pain 29
Sources

Anatomical Context for Paine Syndrome

About this section

MalaCards organs/tissues related to Paine Syndrome:

41
Prostate, Spinal Cord, Brain, Testes, Cortex, Bone, Heart
Sources

Publications for Paine Syndrome

About this section

Articles related to Paine Syndrome:

(show top 50) (show all 2086)
# Title Authors Year
1
Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome. ( 29980635 )
2018
2
Effect of Essential Oil on Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Pilot Randomized Controlled Trial. ( 29948596 )
2018
3
Signs and Symptoms in 1043 Patients with Complex Regional Pain Syndrome (CRPS). ( 29409933 )
2018
4
Management of chronic prostatitis/chronic pelvic pain syndrome. ( 29875042 )
2018
5
Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire. A useful tool for the diagnosis of bladder pain syndrome. ( 29650471 )
2018
6
Safety and Feasibility of Intravesical Instillation of Botulinum Toxin-A in Hydrogel-based Slow-release Delivery System in Patients With Interstitial Cystitis-Bladder Pain Syndrome: A Pilot Study. ( 29307733 )
2018
7
Topical Ketamine in the Treatment of Complex Regional Pain Syndrome. ( 29877864 )
2018
8
Urinary and psychological outcomes in women with interstitial cystitis/bladder pain syndrome following hyaluronic acid treatment. ( 29880165 )
2018
9
Crosstalk between the immune system and neural pathways in interstitial cystitis/bladder pain syndrome. ( 29906407 )
2018
10
Pathophysiology and Management of Abdominal Myofascial Pain Syndrome (AMPS): A Three-Year Prospective Audit of a Management Pathway in 120 Patients. ( 29444277 )
2018
11
The efficacy of botulinum toxin A and sacral neuromodulation in the management of interstitial cystitis (IC)/bladder pain syndrome (BPS), what do we know? ICI-RS 2017 think thank, Bristol. ( 29363792 )
2018
12
Nonspecific Chronic Anteromedial Knee Pain Neuroma as a Cause of Infrapatellar Pain Syndrome: Case Study and Literature Review. ( 29404377 )
2018
13
The Distinction of Hot Herbal Compress, Hot Compress, and Topical Diclofenac as Myofascial Pain Syndrome Treatment. ( 29405762 )
2018
14
Animal Model of Interstitial Cystitis/Bladder Pain Syndrome. ( 29385782 )
2018
15
Differences in Urodynamic Parameters According to the Presence of a Hunner Lesion in Women With Interstitial Cystitis/Bladder Pain Syndrome. ( 29385787 )
2018
16
Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome. ( 29385788 )
2018
17
Fear of movement modulates the feedforward motor control of the affected limb in complex regional pain syndrome (CRPS): A single-case study. ( 29317053 )
2018
18
Downregulation of WNT11 is associated with bladder tissue fibrosis in patients with interstitial cystitis/bladder pain syndrome without Hunner lesion. ( 29955137 )
2018
19
Involvement of prostatic interstitial cells of Cajal in inflammatory cytokines-elicited catecholamines production: Implications for the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). ( 29649477 )
2018
20
Concurrent validation of a pressure pain threshold scale for individuals with myofascial pain syndrome and fibromyalgia. ( 29456445 )
2018
21
Treatment of refractory category III nonbacterial chronic prostatitis/chronic pelvic pain syndrome with intraprostatic injection of onabotulinumtoxinA: a prospective controlled study. ( 29680006 )
2018
22
Challenging the Cinderella Hypothesis: A New Model for the Role of the Motor Unit Recruitment Pattern in the Pathogenesis of Myofascial Pain Syndrome in Postural Muscles. ( 29944114 )
2018
23
Correlates and importance of neglect-like symptoms in Complex Regional Pain Syndrome. ( 29419655 )
2018
24
Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC). ( 29341502 )
2018
25
Mycophenolate for persistent complex regional pain syndrome, a parallel, open, randomised, proof of concept trial. ( 29794285 )
2018
26
Greater trochanteric pain syndrome and gluteus medius and minimus tendinosis: nonsurgical treatment. ( 29182042 )
2018
27
The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis. ( 29404715 )
2018
28
Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology. ( 29794269 )
2018
29
Complex Regional Pain Syndrome Type 1: Diagnosis and Management. ( 29409405 )
2018
30
Endometriosis increased the risk of bladder pain syndrome/interstitial cystitis: A population-based study. ( 29318645 )
2018
31
Epstein-Barr Virus Presence as a Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis/Bladder Pain Syndrome. ( 29653163 )
2018
32
Effects of vision and cognitive load on static postural control in subjects with and without patellofemoral pain syndrome. ( 29120261 )
2018
33
The effect of patellar taping on lower extremity running kinematics in individuals with patellofemoral pain syndrome. ( 29601217 )
2018
34
The Effectiveness of Dry Needling and Exercise Therapy in Patients with Dizziness Caused By Cervical Myofascial Pain Syndrome; Prospective Randomized Clinical Study. ( 29718418 )
2018
35
Combination of exercise and acupuncture vs acupuncture alone for treatment of myofascial pain syndrome: A randomized clinical trial. ( 29746993 )
2018
36
Prevalence of myofascial pain syndrome in patients with incurable cancer. ( 29861227 )
2018
37
Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia. ( 29419627 )
2018
38
FDA Brudac 2018 Criteria for Interstitial Cystitis/Bladder Pain Syndrome Clinical Trials: Future Direction for IC/BPS Research. ( 29452126 )
2018
39
Long-term Outcomes Using Intrathecal Drug Delivery Systems in Complex Regional Pain Syndrome. ( 29889241 )
2018
40
Management of interstitial cystitis/bladder pain syndrome. ( 29875041 )
2018
41
The Legal Doctrine on the Liability of Physicians in Medical Malpractice Lawsuits Involving Complex Regional Pain Syndrome. ( 29441736 )
2018
42
Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study. ( 29336203 )
2018
43
Acupuncture for chronic prostatitis/chronic pelvic pain syndrome: a randomized, sham acupuncture-controlled trial. ( 29733836 )
2018
44
Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome/interstitial cystitis. ( 29797500 )
2018
45
Spinal cord stimulation in the treatment of complex regional pain syndrome type 1: Is trial truly required? ( 29913360 )
2018
46
Complex Regional Pain Syndrome, Current Concepts and Treatment Options. ( 29404787 )
2018
47
Spinal Cord Stimulation with Percutaneous Type Lead in a Deaf Patient with Complex Regional Pain Syndrome Type II. ( 29316194 )
2018
48
Evaluation of Pain Syndromes, Headache, and Temporomandibular Joint Disorders in Children. ( 29153234 )
2018
49
Bladder pain syndrome/interstitial cystitis is associated with asthma: A case-control study. ( 29441652 )
2018
50
Methodological Issues on the Accuracy and Precision of Clinical Examination in the Diagnosis of Myofascial Pain Syndrome. ( 29788387 )
2018
Sources

Variations for Paine Syndrome

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ClinVar genetic disease variations for Paine Syndrome:

6
(show all 16)
# Gene Variation Type Significance SNP ID Assembly Location
1 KIF1B NM_015074.3(KIF1B): c.2473G> A (p.Glu825Lys) single nucleotide variant Uncertain significance rs763122049 GRCh37 Chromosome 1, 10384889: 10384889
2 KIF1B NM_015074.3(KIF1B): c.2473G> A (p.Glu825Lys) single nucleotide variant Uncertain significance rs763122049 GRCh38 Chromosome 1, 10324831: 10324831
3 SELENON NM_020451.2(SELENON): c.482G> A (p.Arg161Gln) single nucleotide variant Uncertain significance rs765749301 GRCh38 Chromosome 1, 25805220: 25805220
4 SELENON NM_020451.2(SELENON): c.482G> A (p.Arg161Gln) single nucleotide variant Uncertain significance rs765749301 GRCh37 Chromosome 1, 26131711: 26131711
5 OAT NM_000274.3(OAT): c.875A> G (p.Lys292Arg) single nucleotide variant Likely pathogenic rs1057518927 GRCh38 Chromosome 10, 124402952: 124402952
6 OAT NM_000274.3(OAT): c.875A> G (p.Lys292Arg) single nucleotide variant Likely pathogenic rs1057518927 GRCh37 Chromosome 10, 126091521: 126091521
7 SCN4A NM_000334.4(SCN4A): c.1333G> T (p.Val445Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs121908552 GRCh37 Chromosome 17, 62041947: 62041947
8 SCN4A NM_000334.4(SCN4A): c.1333G> T (p.Val445Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs121908552 GRCh38 Chromosome 17, 63964587: 63964587
9 GJB1 NM_001097642.2(GJB1): c.109G> T (p.Val37Leu) single nucleotide variant Likely pathogenic rs1057518946 GRCh37 Chromosome X, 70443666: 70443666
10 GJB1 NM_001097642.2(GJB1): c.109G> T (p.Val37Leu) single nucleotide variant Likely pathogenic rs1057518946 GRCh38 Chromosome X, 71223816: 71223816
11 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic GRCh37 Chromosome 9, 137593133: 137593133
12 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic GRCh38 Chromosome 9, 134701287: 134701287
13 PTPRQ NM_001145026.1(PTPRQ): c.6475C> T (p.Arg2159Ter) single nucleotide variant Pathogenic GRCh37 Chromosome 12, 81064144: 81064144
14 PTPRQ NM_001145026.1(PTPRQ): c.6475C> T (p.Arg2159Ter) single nucleotide variant Pathogenic GRCh38 Chromosome 12, 80670365: 80670365
15 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 4102388: 4102388
16 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 4102390: 4102390
Sources

Expression for Paine Syndrome

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Search GEO for disease gene expression data for Paine Syndrome.
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Pathways for Paine Syndrome

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Pathways related to Paine Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Development Endothelin-1/EDNRA signaling 22
Show member pathways
 12.32 IL1B NGF TRPA1 TRPV1
2
Neuropathic Pain-Signaling in Dorsal Horn Neurons 64
Show member pathways
 12.3 SCN10A SCN11A SCN9A TAC1
3
Neuroscience 4
12.16 NGF SCN10A SCN11A SCN9A
4
Cardiac conduction 66
Show member pathways
 12.08 ATP12A ATP4A SCN10A SCN11A SCN9A
5
Ion channel transport 66
Show member pathways
 12.05 ATP12A ATP4A TRPA1 TRPV1
6
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.87 IL1B NGF TAC1
7
L1CAM interactions 66
Show member pathways
 11.64 SCN10A SCN11A SCN9A
8
Phase 0 - rapid depolarisation 66
Show member pathways
 11.21 SCN10A SCN11A SCN9A
9
Trk receptor signaling mediated by PI3K and PLC-gamma 1
11 NGF TRPV1
10
TRP channels 66
10.85 TRPA1 TRPV1
11
Interaction between L1 and Ankyrins 66
10.28 SCN10A SCN11A SCN9A
Sources

GO Terms for Paine Syndrome

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Cellular components related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stereocilium bundle GO:0032421 8.96 PTPRQ TRPA1
2 voltage-gated sodium channel complex GO:0001518 8.8 SCN10A SCN11A SCN9A

Biological processes related to Paine Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.92 SCN10A SCN11A SCN9A TRPA1 TRPV1
2 inflammatory response GO:0006954 9.88 IL1B SCN9A TAC1 TRPV1
3 ion transport GO:0006811 9.8 ATP12A ATP4A SCN10A SCN11A SCN9A TRPA1
4 regulation of ion transmembrane transport GO:0034765 9.77 SCN10A SCN11A SCN9A
5 sodium ion transmembrane transport GO:0035725 9.67 SCN10A SCN11A SCN9A
6 ion transmembrane transport GO:0034220 9.63 ATP12A ATP4A SCN11A SCN9A TRPA1 TRPV1
7 ATP hydrolysis coupled proton transport GO:0015991 9.6 ATP12A ATP4A
8 cellular sodium ion homeostasis GO:0006883 9.58 ATP12A ATP4A
9 membrane depolarization during action potential GO:0086010 9.58 SCN10A SCN11A SCN9A
10 potassium ion homeostasis GO:0055075 9.57 ATP12A UPK3A
11 cellular potassium ion homeostasis GO:0030007 9.56 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.55 ATP12A ATP4A
13 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.54 ATP12A ATP4A
14 neuronal action potential GO:0019228 9.54 SCN10A SCN11A SCN9A
15 behavioral response to pain GO:0048266 9.51 SCN9A TRPV1
16 response to pain GO:0048265 9.5 TAC1 TRPA1 TRPV1
17 fever generation GO:0001660 9.48 IL1B TRPV1
18 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.46 TRPA1 TRPV1
19 thermoception GO:0050955 9.43 TRPA1 TRPV1
20 sodium ion transport GO:0006814 9.35 ATP12A ATP4A SCN10A SCN11A SCN9A
21 sensory perception of pain GO:0019233 9.02 SCN10A SCN9A TAC1 TRPA1 TRPV1

Molecular functions related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.61 SCN10A SCN11A SCN9A
2 ion channel activity GO:0005216 9.56 SCN10A SCN11A SCN9A TRPV1
3 calcium-release channel activity GO:0015278 9.4 TRPA1 TRPV1
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP12A ATP4A
5 sodium channel activity GO:0005272 9.33 SCN10A SCN11A SCN9A
6 potassium:proton exchanging ATPase activity GO:0008900 9.32 ATP12A ATP4A
7 voltage-gated sodium channel activity GO:0005248 9.13 SCN10A SCN11A SCN9A
8 cation channel activity GO:0005261 8.92 SCN10A SCN11A SCN9A TRPV1
Sources

Sources for Paine Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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