PAIN
MCID: PNS012
MIFTS: 61

Paine Syndrome (PAIN)

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Paine Syndrome

MalaCards integrated aliases for Paine Syndrome:

Name: Paine Syndrome 56 52 71
Pain Disorder 12 54 15 71
Pain 6 42 17
Microcephaly with Spastic Diplegia 56 52
Pain Syndrome 15

Characteristics:

OMIM:

56
Inheritance:
x-linked


HPO:

31
paine syndrome:
Inheritance x-linked inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0060164
OMIM 56 311400
ICD10 32 R52 R52.9
MedGen 41 C1412041
UMLS 71 C0391976 C1412041

Summaries for Paine Syndrome

MedlinePlus : 42 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen, chest, pelvis, or you may feel pain all over. Pain can be helpful in diagnosing a problem. If you never felt pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. There are two types of pain: acute and chronic. Acute pain usually comes on suddenly, because of a disease, injury, or inflammation. It can often be diagnosed and treated. It usually goes away, though sometimes it can turn into chronic pain. Chronic pain lasts for a long time, and can cause severe problems. Pain is not always curable, but there are many ways to treat it. Treatment depends on the cause and type of pain. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Paine Syndrome, also known as pain disorder, is related to complex regional pain syndrome and familial episodic pain syndrome. An important gene associated with Paine Syndrome is PTPRQ (Protein Tyrosine Phosphatase Receptor Type Q), and among its related pathways/superpathways are Peptide ligand-binding receptors and G-Beta Gamma Signaling. The drugs Nalbuphine and Imipramine have been mentioned in the context of this disorder. Affiliated tissues include breast, spinal cord and testes, and related phenotypes are microcephaly and olivopontocerebellar hypoplasia

Disease Ontology : 12 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

More information from OMIM: 311400

Related Diseases for Paine Syndrome

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Paine Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3694)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 34.6 TAC1 SCN9A CALCA
2 familial episodic pain syndrome 34.6 TRPA1 SCN11A
3 myofascial pain syndrome 34.3 TRPV1 TAC1 NPS CALCA
4 interstitial cystitis 33.6 TRPV1 TAC1 SCN9A P2RX3 NGF
5 reflex sympathetic dystrophy 33.6 TAC1 NPS CALCA
6 neuropathy, hereditary sensory and autonomic, type vii 33.5 SCN3A SCN1A SCN11A SCN10A
7 causalgia 33.5 TAC1 NPS CALCA
8 fibromyalgia 32.8 SCN9A PNOC OPRM1 NGF CALCA
9 algoneurodystrophy 32.6 NGF CALCA
10 paroxysmal extreme pain disorder 32.3 TRPV1 SCN9A SCN11A SCN10A
11 photokeratitis 32.2 TRPV1 TRPM8 TRPA1
12 prurigo nodularis 32.1 TAC1 NGF
13 familial hemiplegic migraine 32.0 SCN1A OPRM1 CALCA
14 nerve compression syndrome 31.9 TAC1 NGF CALCA
15 cystitis 31.8 TRPV1 TAC1 P2RX3 NGF
16 polyradiculopathy 31.7 TRPV1 TAC1 SCN9A NPS NGF CALCA
17 epileptic encephalopathy, early infantile, 13 31.4 SCN8A SCN1A
18 low compliance bladder 31.1 P2RX3 NGF
19 autonomic nervous system disease 31.0 TRPV1 TAC1 SCN9A OPRM1 NPS NGF
20 irritable bowel syndrome 30.9 TRPV1 TRPA1 TAC1 OPRM1 NGF
21 headache 30.9 TAC1 SCN1A CALCA
22 erythermalgia, primary 30.8 SCN9A SCN11A SCN10A
23 cluster headache 30.7 PNOC CALCA
24 peripheral nervous system disease 30.6 TRPV1 TRPM8 TRPA1 TAC1 SCN9A SCN11A
25 hemiplegia 30.6 TAC1 SCN1A CALCA
26 disease of mental health 30.6 TAC1 OPRM1 NPS NGF H2AC18
27 neuroma 30.5 TRPV1 SCN10A NGF CALCA
28 progressive familial heart block, type ib 30.5 TRPV1 TRPM8 TRPA1
29 diabetic neuropathy 30.5 TRPV1 TRPM8 SCN9A NGF CALCA
30 constipation 30.4 TAC1 OPRM1 GAL CALCA
31 neurogenic arthropathy 30.3 SCN9A NGF CALCA
32 migraine with aura 30.3 TRPM8 SCN1A OPRM1 CALCA
33 dentin sensitivity 30.3 TRPV1 TRPM8 TRPA1
34 alcohol use disorder 30.3 OPRM1 H2AC18 GAL
35 epicondylitis 30.2 TAC1 NPS CALCA
36 anxiety 30.2 TAC1 PNOC OPRM1 NPS NGF GAL
37 sensory peripheral neuropathy 30.2 TRPV1 TAC1 NGF
38 mononeuropathy 30.2 TRPV1 TAC1 NGF GAL
39 urethral syndrome 30.2 TAC1 P2RX3 NGF
40 erythromelalgia 30.1 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
41 indifference to pain, congenital, autosomal recessive 30.1 SCN9A SCN11A SCN10A
42 hemiplegic migraine 30.1 SCN1A OPRM1 CALCA
43 pulpitis 30.1 TRPV1 TAC1 SCN8A
44 autonomic neuropathy 30.1 SCN9A SCN11A NGF
45 opioid addiction 30.0 PNOC OPRM1
46 sodium channelopathy-related small fiber neuropathy 30.0 SCN9A SCN11A SCN10A
47 chronic cystitis 30.0 TRPV1 TAC1 P2RX3 NGF
48 subungual glomus tumor 30.0 TRPV1 TAC1
49 vasomotor rhinitis 29.9 TRPV1 TAC1 NPS CALCA
50 brugada syndrome 29.9 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A

Graphical network of the top 20 diseases related to Paine Syndrome:



Diseases related to Paine Syndrome

Symptoms & Phenotypes for Paine Syndrome

Human phenotypes related to Paine Syndrome:

31
# Description HPO Frequency HPO Source Accession
1 microcephaly 31 HP:0000252
2 olivopontocerebellar hypoplasia 31 HP:0006955
3 generalized myoclonic seizures 31 HP:0002123
4 spastic diplegia 31 HP:0001264

Symptoms via clinical synopsis from OMIM:

56
Head:
microcephaly
hypoplasia of cerebellum, inferior olives and pons

Lab:
variable elevated spinal fluid amino acids

Neuro:
spastic diplegia
myoclonic seizures
absent abdominal reflexes

Clinical features from OMIM:

311400

MGI Mouse Phenotypes related to Paine Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 GAL NGF OPRM1 P2RX3 PNOC PTPRQ
2 integument MP:0010771 9.73 GAL NGF OPRM1 P2RX3 PNOC SCN10A
3 nervous system MP:0003631 9.44 GAL NGF OPRM1 P2RX3 PTPRQ SCN10A

Drugs & Therapeutics for Paine Syndrome

Drugs for Paine Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 818)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
2
Imipramine Approved Phase 4 50-49-7 3696
3
Flunarizine Approved Phase 4 52468-60-7 941361
4 Pinaverium Approved Phase 4 59995-65-2
5
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
6
Zoledronic Acid Approved Phase 4 118072-93-8 68740
7
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
8
Levetiracetam Approved Phase 4 102767-28-2 441341
9
Cyclobenzaprine Approved Phase 4 303-53-7 2895
10
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
11
Histamine Approved, Investigational Phase 4 51-45-6 774
12
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
13
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
14
Cetirizine Approved Phase 4 83881-51-0 2678
15
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
16
Tropisetron Approved, Investigational Phase 4 105826-92-4, 89565-68-4 5595
17
Loperamide Approved Phase 4 53179-11-6 3955
18
Desflurane Approved Phase 4 57041-67-5 42113
19
Hydroxyzine Approved Phase 4 68-88-2 3658
20 Ginger Approved Phase 4
21
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
22
Apomorphine Approved, Investigational Phase 4 58-00-4, 41372-20-7 6005
23
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
24
Promethazine Approved, Investigational Phase 4 60-87-7 4927
25
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
26
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
27
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
28
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
29
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
30
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
31
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
32
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
33
Dipivefrin Approved Phase 4 52365-63-6 3105
34
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
35
Opium Approved, Illicit Phase 4 8008-60-4
36
Belladonna Approved, Experimental Phase 4
37
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
38
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
39
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
40
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
41
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
42
Butorphanol Approved, Illicit, Vet_approved Phase 4 42408-82-2, 58786-99-5 5361092
43
Chlorzoxazone Approved Phase 4 95-25-0 2733
44
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
45
Mefenamic acid Approved Phase 4 61-68-7 4044
46
Eletriptan Approved, Investigational Phase 4 143322-58-1 77993
47
Caffeine Approved Phase 4 58-08-2 2519
48
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
49
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
50
Sertraline Approved Phase 4 79617-96-2 68617

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
2 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
3 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
4 Pain Scale in the Use of Topical Anesthesia in Small Gauge Vitrectomy Unknown status NCT01022879 Phase 4
5 A Randomized, Placebo-Controlled, Double-Blind, Two-Part, Cross-over Study to Compare the Reduction in Pain Intensity After Single-Dose Administration of IV or Oral Acetaminophen and IV Morphine by Using UVB or IDC Pain Models Unknown status NCT02678416 Phase 4 IV Acetaminophen;IV Morphine;Acetaminophen tablets
6 Assessment of Pregabalin Efficacy for the Treatment and Prevention of At-level Non-evoked and Evoked Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
7 Ketoprofen Gel vs Placebo in Patients Presented With Low-back Pain to Emergency Department: A Ranodmized Controlled Trial Unknown status NCT02491879 Phase 4 Ketoprofen
8 Efficacy and Safety of Intranasal Ketorolac Tromethamine (SPRIX) as a Short Term Pain Management Tool for Adult Male Patients With Post-Vasectomy Pain Unknown status NCT02000388 Phase 4 Ketorolac Tromethamine
9 Comparison of Two Different Circumcision Surgical Technique on Postoperative Pain Unknown status NCT01909765 Phase 4
10 Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
11 Intranasal Fentanyl in Treatment of Labour Pain - Efficacy and Safety Unknown status NCT02571179 Phase 4 intranasal fentanyl 50 microg dose up to 250 microg
12 An Enriched Enrollment, Double-Blind, Placebo-Controlled, Parallel Group, Randomized Withdrawal Trial to Evaluate the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Moderate to Severe Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
13 The Safety and Efficacy of 5% Lidocaine Patch and Flurbiprofen Patch for Relieving Acute Low Back Pain Unknown status NCT03171987 Phase 4 Lidocaine patch local application;Flurbiprofen patch local application
14 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy: A Randomized Double-blind Controlled Trial Unknown status NCT01099605 Phase 4
15 Naproxen for Acute Pain After Surgery: A Randomized, Placebo-Controlled Trial Unknown status NCT00615875 Phase 4 naproxen;placebo
16 Lidocaine for Pain Control During Intrauterine Device Insertion: A Randomized Clinical Trial Unknown status NCT03362905 Phase 4 Lidocaine topical
17 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain:Randomized-Controlled Clinical Trail Unknown status NCT02125968 Phase 4
18 The Effect of Naproxen Sodium + Codeine, and Paracetamol+ Codeine on Postoperative Laminectomy Pain Unknown status NCT02255955 Phase 4 550 mg naproxen sodium and 30mg codeine;300 mg paracetamol and 30 mg codeine;placebo tablet
19 Efficacy of Intravenous Naproksen Sodium+Codein and Paracetamol+Codein on Postoperative Pain and Contramal Consumption After a Lumbar Disk Surgery Unknown status NCT02252614 Phase 4 naproxen sodium codein;paracetamol codein;Placebo
20 Phase 4 Study of Topical NSAID for Ophthalmologic Use: Pain Measurement After First Drop. Unknown status NCT00869219 Phase 4 Nevanac;Acular LS
21 Port Site Infiltration With Bupivacaine for Reduction of Postoperative Pain in Woman Undergoing Gynecologic Laparoscopy: A Randomized, Factorial, Double-Blind, Controlled Trial Unknown status NCT03259243 Phase 4 Bupivacaine Hydrochloride
22 Is There Any Relation Between Pain and Stone Location in Retrograde Intrarenal Surgery? Unknown status NCT02430883 Phase 4
23 Effectiveness of Intraoperative Exparel, a Bupivacaine Liposome Injectable Suspension, for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study Unknown status NCT02808728 Phase 4 Pain Cocktail with Exparel;Pain Cocktail with Ropivacaine
24 Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial Unknown status NCT02619695 Phase 4 Fastjel
25 Pharmacological Anxiolysis With Promethazine as an Adjunctive Therapy for Acute Low Back Pain in the Adult Emergency Department Unknown status NCT01129934 Phase 4 Morphine-Promethazine;morphine
26 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
27 Phase IV Pilot Study of Ulipristal Acetate for Treatment of Endometriosis-related Pelvic Pain Unknown status NCT02213081 Phase 4 Ulipristal
28 Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study Unknown status NCT02570230 Phase 4 Ketamine
29 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
30 Effect of Three Therapeutic Strategies on the Restriction of the Participation of Patients With a Chronic Back Pain : Multidisciplinary is it the Key Component ? Unknown status NCT02030171 Phase 4
31 The Effect of Oxycodone to the Placental Circulation at Early Labour Unknown status NCT02573831 Phase 4 Oxycodone;Placebo
32 Intravenous Terbutaline to Facilitate Epidural Catheter Placement for Parturients With Labor Pain Unknown status NCT01651962 Phase 4 Terbutaline;Fentanyl;0.9% NaCl
33 a Randomized Controlled Trial of Dexmedetomidine on Chronic Postoperative Pain After Breast and Thoracic Surgery Unknown status NCT03275207 Phase 4 saline;dexmedetomidine
34 Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy Unknown status NCT02997215 Phase 4 Lidocaine;Saline Placebo
35 A Double-Blind, Randomized, Placebo-Controlled Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain (Lbp) Unknown status NCT00444990 Phase 4
36 Comparison of TAP Block With Two Different Doses of Levobupivacaine for Postoperative Pain Management in Pediatric Patients Unknown status NCT02567487 Phase 4 Levobupivacaine
37 Effect of the Administration of Etoricoxib on Postoperative Pain and Quality of Recovery in Patients Undergoing Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
38 Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy Unknown status NCT03051503 Phase 4 The Transdermal Therapeutic System-Fentanyl (TTS-F)
39 The Comparison of 0.15 Milligram Spinal Morphine vs.no Treatment for Morphine Requirement After Video-assisted Thoracoscopic Surgery. A Pilot Randomized Control Study Unknown status NCT01979354 Phase 4 Spinal morphine
40 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
41 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
42 Lidocaine Patch for Postoperative Analgesia After Laparoscopic Cholecystectomy Unknown status NCT01485939 Phase 4
43 A Double-Blind, Placebo-Controlled, Crossover Pilot Study of the Efficacy of Celecoxib 200 Mg Qd in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee Unknown status NCT00194090 Phase 4 celecoxib
44 Preemptive Paracetamol for Postoperative Pain: a Randomised, Double-blind, Two Way Crossover Trial Unknown status NCT02425254 Phase 4 Intravenous paracetamol;Intravenous saline 0.9%
45 Role of Peritubal Infiltration of 0.25% Bupivacaine in Percutaneous Nephrolithotomy (PCNL) in Postoperative Pain Control Unknown status NCT02198027 Phase 4 Bupivacaine
46 A Comparison Between Lidocaine-Prilocaine Cream (EMLA) Application And Wound Infiltration With Lidocaine For Post Caesarean Section Pain Relief : A Randomized Controlled Trial Unknown status NCT02549105 Phase 4 EMLA CREAM 5 mg;LIDOCAINE 1 %
47 Comparison of the Two Different Doses of Dexamethasone on Persistent Mastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
48 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
49 Evaluation of Analgesic Efficacy of Etoricoxib Compared With Ibuprofen in Third Molar Extraction Pain. Unknown status NCT00855777 Phase 4 etoricoxib;ibuprofen
50 The Analgesic Effects of Morphine Versus Ketorolac in Low Back Pain Unknown status NCT02782286 Phase 4 Ketorolac;Morphine

Search NIH Clinical Center for Paine Syndrome

Genetic Tests for Paine Syndrome

Anatomical Context for Paine Syndrome

MalaCards organs/tissues related to Paine Syndrome:

40
Breast, Spinal Cord, Testes, Bone, Brain, Prostate, Skin

Publications for Paine Syndrome

Articles related to Paine Syndrome:

(show top 50) (show all 958)
# Title Authors PMID Year
1
X-chromosomal recessive microcephaly with epilepsy, spastic tetraplegia and absent abdominal reflexes. New variety of "Paine syndrome"? 61 56
4274173 1973
2
Conference report: International Workshop on the fragile X and X-linked mental retardation. 56
6369987 1984
3
Evaluation of familial biochemically determined mental retardation in children, with special reference to aminoaciduria. 56
14429829 1960
4
The Emergent Evaluation and Treatment of Neck and Back Pain. 42
31757249 2020
5
Pain Management for Orthopedic Injuries. 42
31757252 2020
6
Identifying pain susceptibility phenotypes in knee osteoarthritis. 42
31621573 2019
7
Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder. 61
32029791 2020
8
Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy. 61
32011655 2020
9
Efficacy of Pulsed Low-Frequency Magnetic Field Therapy on Patients with Chronic Low Back Pain: A Randomized Double-Blind Placebo-Controlled Trial. 61
31575112 2020
10
The Science of Addiction Through the Lens of Opioid Treatment for Chronic Noncancer Pain. 61
31606310 2020
11
Pain and the immune system: emerging concepts of IgG-mediated autoimmune pain and immunotherapies. 61
30224548 2020
12
Effectiveness of intradiscal injection of radiopaque gelified ethanol (DiscoGel®) versus percutaneous laser disc decompression in patients with chronic radicular low back pain. 61
31888320 2020
13
Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis? 61
31990749 2020
14
Sleep and Pain in Subjects with Fibromyalgia and Comorbid Insomnia: Double-blind, Crossover, Study of Suvorexant 20 mg versus Placebo. 61
31992394 2020
15
"I did not know it was a medical condition": Predictors, severity and help seeking behaviors of women with female sexual dysfunction in the Volta region of Ghana. 61
31929541 2020
16
The outcome of a temporomandibular joint compression test for the diagnosis of arthralgia is confounded by concurrent myalgia. 61
31025193 2020
17
[Discussion on clinical application of "touching-bone" acupuncture technique]. 61
31930900 2020
18
CRPS is not associated with altered sensorimotor cortex GABA or glutamate. 61
31980452 2020
19
Variations in psychiatric morbidity between traumatized Norwegian, refugees and other immigrant patients in Oslo. 61
31961250 2020
20
Functional symptoms in dermatology: Part 2. 61
31468592 2020
21
Ilioinguinal Neuropathy. 61
31960176 2020
22
Subtle changes of gray matter volume in fibromyalgia reflect chronic musculoskeletal pain rather than disease-specific effects. 61
31448468 2019
23
Persistent dentoalveolar pain disorder: A putative intraoral chronic overlapping pain condition. 61
31797486 2019
24
Economic Impact and Prognostic factors of Functional Dyspepsia in Children. 61
31860540 2019
25
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
26
Approach as a key for success: Reduced avoidance behaviour mediates the effect of exposure therapy for fibromyalgia. 61
31585343 2019
27
Association between low back pain and various everyday performances : Activities of daily living, ability to work and sexual function. 61
31493101 2019
28
Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits. 61
31471472 2019
29
Female sexual dysfunction among married women in the Gaza Strip: an internet-based survey. 61
31580717 2019
30
The Effect of Electric Stimulation Techniques on Pain and Tenderness at the Myofascial Trigger Point: A Systematic Review. 61
30690516 2019
31
Prescription Opioid Use in Patients With and Without Systemic Lupus Erythematosus - Michigan Lupus Epidemiology and Surveillance Program, 2014-2015. 61
31557148 2019
32
Linking Nonrestorative Sleep and Activity Interference Through Pain Catastrophizing and Pain Severity: An Intraday Process Model Among Individuals With Fibromyalgia. 61
31526852 2019
33
Role of coping with negative emotions in cognitive behavioral therapy for persistent somatoform pain disorder: Is it more important than pain catastrophizing? 61
31102312 2019
34
Reflex Sympathetic Dystrophy of the Right Hand following an Acute Traumatic Injury. 61
31608198 2019
35
Burning mouth syndrome-a diagnostic dilemma. 61
30603879 2019
36
[Epidemiological survey of mental disorders in the rural left behind elderly aged 60 years and older in Gansu]. 61
31434422 2019
37
Use of PROMIS-29® in US Veterans: Diagnostic Concordance and Domain Comparisons with the General Population. 61
31144276 2019
38
Altered gray matter volume in sensorimotor and thalamic regions associated with pain in localized provoked vulvodynia: a voxel-based morphometry study. 61
30817440 2019
39
Validity and Reliability of the Fibromyalgia Rapid Screening Tool Among Individuals with Chronic Daily Headache: A Clinic-Based Study. 61
30566656 2019
40
AAPT Diagnostic Criteria for Fibromyalgia. 61
30453109 2019
41
An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives. 61
30892737 2019
42
Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms. 61
31182576 2019
43
Reduced empathic pain processing in patients with somatoform pain disorder: Evidence from behavioral and neurophysiological measures. 61
30878486 2019
44
AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders. 61
30527971 2019
45
Standards for the diagnosis and management of complex regional pain syndrome: Results of a European Pain Federation task force. 61
30620109 2019
46
Microsurgical Resection of Thoracic Meningioma: 2-Dimensional Operative Video. 61
30032268 2019
47
Effectiveness of hot herbal compress versus topical diclofenac in treating patients with myofascial pain syndrome. 61
30963051 2019
48
Female Sexual Dysfunction: A Systematic Review of Outcomes Across Various Treatment Modalities. 61
29402732 2019
49
Effect of Local Anesthetic Versus Botulinum Toxin-A Injections for Myofascial Pain Disorders: A Systematic Review and Meta-Analysis. 61
30589660 2019
50
Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange. 61
30871575 2019

Variations for Paine Syndrome

ClinVar genetic disease variations for Paine Syndrome:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PTPRQ NM_001145026.2(PTPRQ):c.6475C>T (p.Arg2159Ter)SNV Pathogenic 523416 rs1445287184 12:81064144-81064144 12:80670365-80670365
2 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val)SNV Likely pathogenic 523328 rs1554781700 9:137593133-137593133 9:134701287-134701287
3 OAT NM_000274.3(OAT):c.875A>G (p.Lys292Arg)SNV Likely pathogenic 374146 rs1057518927 10:126091521-126091521 10:124402952-124402952
4 SCN4A NM_000334.4(SCN4A):c.1333G>T (p.Val445Leu)SNV Conflicting interpretations of pathogenicity 373945 rs121908552 17:62041947-62041947 17:63964587-63964587
5 GJB1 NM_000166.6(GJB1):c.109G>T (p.Val37Leu)SNV Conflicting interpretations of pathogenicity 374173 rs1057518946 X:70443666-70443666 X:71223816-71223816
6 KIF1B NM_015074.3(KIF1B):c.2473G>A (p.Glu825Lys)SNV Uncertain significance 373920 rs763122049 1:10384889-10384889 1:10324831-10324831
7 SELENON NM_020451.3(SELENON):c.482G>A (p.Arg161Gln)SNV Uncertain significance 373919 rs765749301 1:26131711-26131711 1:25805220-25805220
8 MAP2K2 NM_030662.3(MAP2K2):c.514A>G (p.Lys172Glu)SNV Uncertain significance 523536 rs1413580671 19:4102388-4102388 19:4102390-4102390

Expression for Paine Syndrome

Search GEO for disease gene expression data for Paine Syndrome.

Pathways for Paine Syndrome

Pathways related to Paine Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 TRPV1 TAC1 PNOC P2RX3 OPRM1 NPS
2
Show member pathways
12.78 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
3
Show member pathways
12.61 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
4
Show member pathways
12.46 TAC1 SCN9A SCN8A SCN3A SCN1A SCN11A
5
Show member pathways
12.37 TRPV1 TRPM8 TRPA1 NGF
6 12.29 SCN9A SCN8A SCN1A SCN11A SCN10A OPRM1
7
Show member pathways
11.83 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
8
Show member pathways
11.76 SCN9A SCN3A P2RX3
9
Show member pathways
11.31 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
10 10.94 TRPV1 TRPM8 TRPA1
11 10.58 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A

GO Terms for Paine Syndrome

Cellular components related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 TRPV1 TRPM8 TRPA1 TAC1 SCN9A SCN8A
2 neuronal cell body GO:0043025 9.7 TRPV1 TAC1 SCN1A PNOC P2RX3 GAL
3 axon GO:0030424 9.61 TAC1 SCN9A SCN8A SCN3A SCN1A SCN11A
4 axon initial segment GO:0043194 9.43 SCN8A SCN1A
5 integral component of presynaptic membrane GO:0099056 9.43 SCN10A P2RX3 OPRM1
6 node of Ranvier GO:0033268 9.4 SCN8A SCN1A
7 stereocilium bundle GO:0032421 9.37 TRPA1 PTPRQ
8 voltage-gated sodium channel complex GO:0001518 9.1 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A

Biological processes related to Paine Syndrome according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.09 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN3A
2 ion transport GO:0006811 10.02 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN3A
3 inflammatory response GO:0006954 10 TRPV1 TAC1 SCN9A GAL CALCA
4 regulation of ion transmembrane transport GO:0034765 9.99 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
5 sodium ion transport GO:0006814 9.93 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
6 neuropeptide signaling pathway GO:0007218 9.88 TAC1 PNOC OPRM1 NPS GAL CALCA
7 calcium ion transmembrane transport GO:0070588 9.86 TRPV1 TRPM8 TRPA1 OPRM1
8 sodium ion transmembrane transport GO:0035725 9.85 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
9 ion transmembrane transport GO:0034220 9.81 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN3A
10 excitatory postsynaptic potential GO:0060079 9.79 TRPV1 P2RX3 OPRM1
11 response to pain GO:0048265 9.78 TRPV1 TRPA1 TAC1 CALCA
12 response to heat GO:0009408 9.76 TRPV1 P2RX3 CALCA
13 response to cold GO:0009409 9.75 TRPM8 TRPA1 P2RX3
14 cellular response to nerve growth factor stimulus GO:1990090 9.74 TRPV1 TAC1 CALCA
15 sensory perception of pain GO:0019233 9.73 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1
16 behavioral response to pain GO:0048266 9.71 TRPV1 SCN9A P2RX3
17 sensory perception GO:0007600 9.7 SCN10A PNOC OPRM1
18 thermoception GO:0050955 9.67 TRPV1 TRPM8 TRPA1
19 cellular response to ATP GO:0071318 9.64 TRPV1 P2RX3
20 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.64 TRPV1 CALCA
21 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.63 TRPA1 SCN1A
22 positive regulation of synaptic transmission, GABAergic GO:0032230 9.63 TAC1 NPS
23 negative regulation of heart rate GO:0010459 9.62 TRPV1 TAC1
24 response to temperature stimulus GO:0009266 9.62 TRPM8 P2RX3
25 urinary bladder smooth muscle contraction GO:0014832 9.6 TRPV1 P2RX3
26 positive regulation of action potential GO:0045760 9.59 TAC1 NPS
27 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.55 TRPV1 TRPA1
28 membrane depolarization during action potential GO:0086010 9.43 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
29 neuronal action potential GO:0019228 9.17 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A

Molecular functions related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.76 TRPV1 SCN9A SCN8A SCN3A SCN1A SCN11A
2 voltage-gated ion channel activity GO:0005244 9.73 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
3 calcium channel activity GO:0005262 9.5 TRPV1 TRPM8 TRPA1
4 sodium channel activity GO:0005272 9.43 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A
5 calcium-release channel activity GO:0015278 9.37 TRPV1 TRPA1
6 voltage-gated sodium channel activity GO:0005248 9.1 SCN9A SCN8A SCN3A SCN1A SCN11A SCN10A

Sources for Paine Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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