Paine Syndrome (PAIN)

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Paine Syndrome

MalaCards integrated aliases for Paine Syndrome:

Name: Paine Syndrome 56 52 71
Pain Disorder 12 54 15 71
Pain 6 42 17
Microcephaly with Spastic Diplegia 56 52
Pain Syndrome 15





paine syndrome:
Inheritance x-linked inheritance


External Ids:

Disease Ontology 12 DOID:0060164
OMIM 56 311400
ICD10 32 R52 R52.9
MedGen 41 C1412041
UMLS 71 C0391976 C1412041

Summaries for Paine Syndrome

MedlinePlus : 42 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen, chest, pelvis, or you may feel pain all over. Pain can be helpful in diagnosing a problem. If you never felt pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment. There are two types of pain: acute and chronic. Acute pain usually comes on suddenly, because of a disease, injury, or inflammation. It can often be diagnosed and treated. It usually goes away, though sometimes it can turn into chronic pain. Chronic pain lasts for a long time, and can cause severe problems. Pain is not always curable, but there are many ways to treat it. Treatment depends on the cause and type of pain. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Paine Syndrome, also known as pain disorder, is related to complex regional pain syndrome and episodic pain syndrome, familial, 3. An important gene associated with Paine Syndrome is PTPRQ (Protein Tyrosine Phosphatase Receptor Type Q), and among its related pathways/superpathways are Peptide ligand-binding receptors and G-Beta Gamma Signaling. The drugs Ketoprofen and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include breast, spinal cord and testes, and related phenotypes are microcephaly and spastic diplegia

Disease Ontology : 12 A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

More information from OMIM: 311400

Related Diseases for Paine Syndrome

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Paine Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3724)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 34.6 TAC1 SCN9A MIR548D1 CALCA
2 episodic pain syndrome, familial, 3 34.3 SCN9A SCN3A SCN11A SCN10A
3 familial episodic pain syndrome 34.3 TRPV1 TRPA1 SCN9A SCN11A SCN10A
4 episodic pain syndrome, familial, 2 34.2 SCN9A SCN3A SCN1A SCN10A
5 myofascial pain syndrome 34.1 TRPV1 TAC1 NPS CALCA BDNF
6 reflex sympathetic dystrophy 33.7 TAC1 NPS CALCA
7 neuropathy, hereditary sensory and autonomic, type vii 33.6 SCN3A SCN1A SCN11A
8 causalgia 33.4 TRPV1 TAC1 NPS CALCA
9 interstitial cystitis 33.4 TRPV1 TAC1 SCN9A P2RX3 NGF BDNF
10 fibromyalgia 32.5 SCN9A PNOC P2RX3 OPRM1 NGF CALCA
11 algoneurodystrophy 32.4 TAC1 NPS NGF CALCA
12 photokeratitis 32.4 TRPV1 TRPA1
13 prurigo nodularis 32.2 TAC1 NGF
14 nerve compression syndrome 32.1 TRPV1 TAC1 NGF
15 hyperhidrosis, gustatory 32.1 TRPV1 TRPA1 TAC1
16 familial hemiplegic migraine 31.9 SCN1A P2RX3 OPRM1 CALCA
17 polyradiculopathy 31.8 TRPV1 TAC1 SCN9A NPS NGF CALCA
18 central hypoventilation syndrome, congenital 31.6 TAC1 GAL BDNF
19 disease of mental health 31.6 TAC1 OPRM1 NPS NGF H2AC18 BDNF
20 lesion of sciatic nerve 31.6 TRPV1 NGF
21 cystitis 31.6 TRPV1 TAC1 P2RX3 NGF BDNF
22 paroxysmal extreme pain disorder 31.5 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN11A
23 low compliance bladder 31.0 P2RX3 NPS NGF
24 drug dependence 31.0 PNOC OPRM1 BDNF
25 headache 31.0 TAC1 SCN1A CALCA
26 adrenal gland pheochromocytoma 30.9 NGF BDNF
27 cluster headache 30.8 PNOC CALCA
28 irritable bowel syndrome 30.8 TRPV1 TRPA1 TAC1 OPRM1 NGF BDNF
29 erythermalgia, primary 30.8 SCN9A SCN11A SCN10A
30 diabetic neuropathy 30.7 TRPV1 SCN9A NGF CALCA
31 hemiplegia 30.7 TAC1 SCN1A CALCA
32 neuroma 30.6 TRPV1 SCN10A NGF CALCA
33 mental depression 30.6 NPS H2AC18 BDNF
34 peripheral nervous system disease 30.5 TRPV1 TRPA1 TAC1 SCN9A SCN3A SCN11A
35 neurogenic arthropathy 30.5 NGF CALCA
36 tobacco addiction 30.4 OPRM1 H2AC18 BDNF
37 epicondylitis 30.4 TAC1 NPS CALCA
38 dentin sensitivity 30.4 TRPV1 TRPA1
39 substance dependence 30.3 OPRM1 H2AC18 BDNF
40 alcohol use disorder 30.3 OPRM1 H2AC18 GAL BDNF
41 dermatitis, atopic 30.3 TAC1 NPS NGF BDNF
42 erythromelalgia 30.3 SCN9A SCN3A SCN1A SCN11A SCN10A
43 urethral syndrome 30.2 TAC1 P2RX3 NGF
44 allergic hypersensitivity disease 30.2 TAC1 H2AC18 BDNF
45 cannabis abuse 30.2 OPRM1 NGF BDNF
46 mononeuropathy 30.2 TRPV1 TAC1 NGF GAL
47 body mass index quantitative trait locus 11 30.2 TRPV1 SCN1A NPS H2AC18 GAL BDNF
48 normal pressure hydrocephalus 30.1 PTPRQ NGF BDNF
49 rett syndrome 30.1 SCN1A NGF H2AC18 BDNF
50 autonomic neuropathy 30.1 SCN9A SCN11A NGF

Graphical network of the top 20 diseases related to Paine Syndrome:

Diseases related to Paine Syndrome

Symptoms & Phenotypes for Paine Syndrome

Human phenotypes related to Paine Syndrome:

# Description HPO Frequency HPO Source Accession
1 microcephaly 31 HP:0000252
2 spastic diplegia 31 HP:0001264
3 olivopontocerebellar hypoplasia 31 HP:0006955
4 generalized myoclonic seizure 31 HP:0002123

Symptoms via clinical synopsis from OMIM:

hypoplasia of cerebellum, inferior olives and pons

variable elevated spinal fluid amino acids

spastic diplegia
myoclonic seizures
absent abdominal reflexes

Clinical features from OMIM:


MGI Mouse Phenotypes related to Paine Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 BDNF GAL NGF OPRM1 P2RX3 PNOC
2 integument MP:0010771 10.1 BDNF GAL NGF OPRM1 P2RX3 PNOC
3 nervous system MP:0003631 10.03 BDNF GAL NGF OPRM1 P2RX3 PTPRQ
4 no phenotypic analysis MP:0003012 9.7 BDNF NGF OPRM1 SCN10A SCN3A TRPA1
5 normal MP:0002873 9.56 BDNF NGF OPRM1 SCN1A SCN3A SCN9A
6 taste/olfaction MP:0005394 8.92 BDNF SCN9A TRPA1 TRPV1

Drugs & Therapeutics for Paine Syndrome

Drugs for Paine Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 799)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
Pseudoephedrine Approved Phase 4 90-82-4 7028
Ephedrine Approved Phase 4 299-42-3 9294
Nalbuphine Approved Phase 4 20594-83-6 5311304 5360630
5 Orange Approved Phase 4
Imipramine Approved Phase 4 50-49-7 3696
Meperidine Approved Phase 4 57-42-1 4058
Flunarizine Approved Phase 4 52468-60-7 941361
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
10 Pinaverium Approved Phase 4 59995-65-2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Zoledronic Acid Approved Phase 4 118072-93-8 68740
Levetiracetam Approved Phase 4 102767-28-2 441341
Cyclobenzaprine Approved Phase 4 303-53-7 2895
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
Glycerol Approved, Investigational Phase 4 56-81-5 753
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
Cetirizine Approved Phase 4 83881-51-0 2678
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
Tropisetron Approved, Investigational Phase 4 89565-68-4, 105826-92-4 5595
Desflurane Approved Phase 4 57041-67-5 42113
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
Pantoprazole Approved Phase 4 102625-70-7 4679
Hydroxyzine Approved Phase 4 68-88-2 3658
Nefopam Approved, Investigational Phase 4 13669-70-0
27 Ginger Approved Phase 4
Apomorphine Approved, Investigational Phase 4 41372-20-7, 58-00-4 6005
Lornoxicam Approved, Investigational Phase 4 70374-39-9 5282204
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
Dipivefrin Approved Phase 4 52365-63-6 3105
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
Opium Approved, Illicit Phase 4 8008-60-4
Belladonna Approved, Experimental Phase 4
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
Chlorzoxazone Approved Phase 4 95-25-0 2733
Butorphanol Approved, Illicit, Vet_approved Phase 4 58786-99-5, 42408-82-2 5361092
Mefenamic acid Approved Phase 4 61-68-7 4044
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
Tenoxicam Approved Phase 4 59804-37-4 5312154
Caffeine Approved Phase 4 58-08-2 2519
Eletriptan Approved, Investigational Phase 4 143322-58-1 77993
Lorazepam Approved Phase 4 846-49-1 3958
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
2 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
3 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
4 Pain Scale in the Use of Topical Anesthesia in Small Gauge Vitrectomy Unknown status NCT01022879 Phase 4
5 Assessment of Pregabalin Efficacy for the Treatment and Prevention of At-level Non-evoked and Evoked Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
6 Ketoprofen Gel vs Placebo in Patients Presented With Low-back Pain to Emergency Department: A Ranodmized Controlled Trial Unknown status NCT02491879 Phase 4 Ketoprofen
7 Efficacy and Safety of Intranasal Ketorolac Tromethamine (SPRIX) as a Short Term Pain Management Tool for Adult Male Patients With Post-Vasectomy Pain Unknown status NCT02000388 Phase 4 Ketorolac Tromethamine
8 Comparison of Two Different Circumcision Surgical Technique on Postoperative Pain Unknown status NCT01909765 Phase 4
9 Ultrasound-guided Quadratus Lumborum Block for Postoperative Analgesia After Colostomy: A Randomized Controlled Trial Unknown status NCT02691403 Phase 4 levo-bupivacaine;normal saline
10 Intranasal Fentanyl in Treatment of Labour Pain - Efficacy and Safety Unknown status NCT02571179 Phase 4 intranasal fentanyl 50 microg dose up to 250 microg
11 An Enriched Enrollment, Double-Blind, Placebo-Controlled, Parallel Group, Randomized Withdrawal Trial to Evaluate the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Moderate to Severe Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
12 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy: A Randomized Double-blind Controlled Trial Unknown status NCT01099605 Phase 4
13 Naproxen for Acute Pain After Surgery: A Randomized, Placebo-Controlled Trial Unknown status NCT00615875 Phase 4 naproxen;placebo
14 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain:Randomized-Controlled Clinical Trail Unknown status NCT02125968 Phase 4
15 Lidocaine for Pain Control During Intrauterine Device Insertion: A Randomized Clinical Trial Unknown status NCT03362905 Phase 4 Lidocaine topical
16 The Effect of Naproxen Sodium + Codeine, and Paracetamol+ Codeine on Postoperative Laminectomy Pain Unknown status NCT02255955 Phase 4 550 mg naproxen sodium and 30mg codeine;300 mg paracetamol and 30 mg codeine;placebo tablet
17 Efficacy of Intravenous Naproksen Sodium+Codein and Paracetamol+Codein on Postoperative Pain and Contramal Consumption After a Lumbar Disk Surgery Unknown status NCT02252614 Phase 4 naproxen sodium codein;paracetamol codein;Placebo
18 Phase 4 Study of Topical NSAID for Ophthalmologic Use: Pain Measurement After First Drop. Unknown status NCT00869219 Phase 4 Nevanac;Acular LS
19 Efficacy and Safety of Dexamethasone Versus Betamethasone Epidural Caudal Administration for Treatment of Lumbosacral Radiculalgia: Randomized Clinical Trial Unknown status NCT02833116 Phase 4 Betamethasone;Dexamethasone
20 Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial Unknown status NCT02619695 Phase 4 Fastjel
21 Is There Any Relation Between Pain and Stone Location in Retrograde Intrarenal Surgery? Unknown status NCT02430883 Phase 4
22 Effectiveness of Intraoperative Exparel, a Bupivacaine Liposome Injectable Suspension, for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study Unknown status NCT02808728 Phase 4 Pain Cocktail with Exparel;Pain Cocktail with Ropivacaine
23 Port Site Infiltration With Bupivacaine for Reduction of Postoperative Pain in Woman Undergoing Gynecologic Laparoscopy: A Randomized, Factorial, Double-Blind, Controlled Trial Unknown status NCT03259243 Phase 4 Bupivacaine Hydrochloride
24 Pharmacological Anxiolysis With Promethazine as an Adjunctive Therapy for Acute Low Back Pain in the Adult Emergency Department Unknown status NCT01129934 Phase 4 Morphine-Promethazine;morphine
25 Low Dose Intraoperative Intravenous Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study Unknown status NCT02570230 Phase 4 Ketamine
26 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
27 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
28 Phase IV Pilot Study of Ulipristal Acetate for Treatment of Endometriosis-related Pelvic Pain Unknown status NCT02213081 Phase 4 Ulipristal
29 The Effect of Oxycodone to the Placental Circulation at Early Labour Unknown status NCT02573831 Phase 4 Oxycodone;Placebo
30 Prospective, Randomized, Controlled Comparison of Local Anesthetic Infusion Pump Versus DepoFoam Bupivacaine For Pain Management After Abdominoplasty and TRAM Flap Breast Reconstruction. Unknown status NCT02542956 Phase 4 Exparel;Marcaine;Marcaine
31 Effect of Three Therapeutic Strategies on the Restriction of the Participation of Patients With a Chronic Back Pain : Multidisciplinary is it the Key Component ? Unknown status NCT02030171 Phase 4
32 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Unknown status NCT02527083 Phase 4 Propofol;Sevoflurane;Remifentanil;Ketamine
33 Intravenous Terbutaline to Facilitate Epidural Catheter Placement for Parturients With Labor Pain Unknown status NCT01651962 Phase 4 Terbutaline;Fentanyl;0.9% NaCl
34 Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy Unknown status NCT02997215 Phase 4 Lidocaine;Saline Placebo
35 a Randomized Controlled Trial of Dexmedetomidine on Chronic Postoperative Pain After Breast and Thoracic Surgery Unknown status NCT03275207 Phase 4 saline;dexmedetomidine
36 A Double-Blind, Randomized, Placebo-Controlled Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain (Lbp) Unknown status NCT00444990 Phase 4
37 Comparison of TAP Block With Two Different Doses of Levobupivacaine for Postoperative Pain Management in Pediatric Patients Unknown status NCT02567487 Phase 4 Levobupivacaine
38 Effect of the Administration of Etoricoxib on Postoperative Pain and Quality of Recovery in Patients Undergoing Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
39 The Comparison of 0.15 Milligram Spinal Morphine Treatment for Morphine Requirement After Video-assisted Thoracoscopic Surgery. A Pilot Randomized Control Study Unknown status NCT01979354 Phase 4 Spinal morphine
40 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
41 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
42 Efficacy of Transdermal Fentanyl Patches in Relief of Acute Postoperative Pain After Mastectomy Unknown status NCT03051503 Phase 4 The Transdermal Therapeutic System-Fentanyl (TTS-F)
43 Preemptive Paracetamol for Postoperative Pain: a Randomised, Double-blind, Two Way Crossover Trial Unknown status NCT02425254 Phase 4 Intravenous paracetamol;Intravenous saline 0.9%
44 Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty Unknown status NCT00864409 Phase 4 ropivacaine 0,2%;saline.9%
45 Evaluation of Analgesic Efficacy of Etoricoxib Compared With Ibuprofen in Third Molar Extraction Pain. Unknown status NCT00855777 Phase 4 etoricoxib;ibuprofen
46 Comparison of the Two Different Doses of Dexamethasone on Persistent Mastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
47 A Comparison Between Lidocaine-Prilocaine Cream (EMLA) Application And Wound Infiltration With Lidocaine For Post Caesarean Section Pain Relief : A Randomized Controlled Trial Unknown status NCT02549105 Phase 4 EMLA CREAM 5 mg;LIDOCAINE 1 %
48 The Analgesic Effects of Morphine Versus Ketorolac in Low Back Pain Unknown status NCT02782286 Phase 4 Ketorolac;Morphine
49 A Double-Blind, Placebo-Controlled, Crossover Pilot Study of the Efficacy of Celecoxib 200 Mg Qd in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee Unknown status NCT00194090 Phase 4 celecoxib
50 Intraartikulær Versus ekstraartikulær Bolus Injektion Med Ropivacain Ved Total knæalloplastik: et Prospektivt, Randomiseret, Dobbeltblindet, Kontrolleret Studie Unknown status NCT00632580 Phase 4 intraarticular injection with ropivacaine;extraarticular injection with ropivacaine

Search NIH Clinical Center for Paine Syndrome

Genetic Tests for Paine Syndrome

Anatomical Context for Paine Syndrome

MalaCards organs/tissues related to Paine Syndrome:

Breast, Spinal Cord, Testes, Brain, Bone, Prostate, Skin

Publications for Paine Syndrome

Articles related to Paine Syndrome:

(show top 50) (show all 978)
# Title Authors PMID Year
X-chromosomal recessive microcephaly with epilepsy, spastic tetraplegia and absent abdominal reflexes. New variety of "Paine syndrome"? 56 61
4274173 1973
Conference report: International Workshop on the fragile X and X-linked mental retardation. 56
6369987 1984
Evaluation of familial biochemically determined mental retardation in children, with special reference to aminoaciduria. 56
14429829 1960
The Use of Botulinum Toxin in Pain Management: Basic Science and Clinical Applications. 42
32097334 2020
Transition From Acute to Chronic Pain in Lower Extremity Fracture Patients: A Pain Phenotyping Protocol. 42
31977841 2020
The Adolescent Knee Pain (AK-Pain) prognostic tool: protocol for a prospective cohort study. 42
32399187 2019
Understanding and managing pelvic girdle pain from a person-centred biopsychosocial perspective. 61
32560860 2020
Optimizing the Treatment of CRPS With Ketamine. 61
32243301 2020
Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis? 61
31990749 2020
Pain Neuroscience Education for Children with Functional Abdominal Pain Disorders: A Randomized Comparative Pilot Study. 61
32526929 2020
The effect of multisensory illusions on pain and perceived burning sensations in patients with Burning Mouth Syndrome: A proof-of-concept study. 61
32531809 2020
Non-Odontogenic Odontalgia Referred from the Temporal Tendon: A Case Report. 61
32561237 2020
Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome. 61
32510695 2020
Identification of herbal categories active in pain disorder subtypes by machine learning help reveal novel molecular mechanisms of algesia. 61
32278044 2020
Fecal Calprotectin as a Useful Non-Invasive Screening Marker for Eosinophilic Gastrointestinal Disorder in Korean Children. 61
32356420 2020
Trends in Opioid Usage Following Tympanoplasty and Mastoidectomy. 61
32558746 2020
Long-term opioid therapy of non-cancer pain : Prevalence and predictors of hospitalization in the event of possible misuse. 61
30327867 2020
Paroxysmal extreme pain disorder in family with c.3892G > T (p.Val1298Phe) in the SCN9A gene mutation - case report. 61
32404070 2020
Association Between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease. 61
32352482 2020
Economic Impact and Prognostic Factors of Functional Dyspepsia in Children. 61
31860540 2020
Sleep and pain in humans with fibromyalgia and comorbid insomnia: double-blind, crossover study of suvorexant 20 mg versus placebo. 61
31992394 2020
Pediatric Persistent Pain: Associations Among Sensory Modulation, Attachment, Functional Disability, and Quality of Life. 61
32204782 2020
Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy. 61
32011655 2020
Back disorder incidence and occupation in Denmark: a cross-sectional register-based study. 61
32219598 2020
The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice. 61
32193635 2020
The effect of alexithymia and depressive feelings on pain perception in somatoform pain disorder. 61
32224345 2020
Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder. 61
32029791 2020
The Science of Addiction Through the Lens of Opioid Treatment for Chronic Noncancer Pain. 61
31606310 2020
Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids. 61
32091630 2020
Efficacy of Pulsed Low-Frequency Magnetic Field Therapy on Patients with Chronic Low Back Pain: A Randomized Double-Blind Placebo-Controlled Trial. 61
31575112 2020
Pain and the immune system: emerging concepts of IgG-mediated autoimmune pain and immunotherapies. 61
30224548 2020
Effectiveness of intradiscal injection of radiopaque gelified ethanol (DiscoGel®) versus percutaneous laser disc decompression in patients with chronic radicular low back pain. 61
31888320 2020
The Effects of Racial/Ethnic Minority Status on Sleep, Mood Disturbance, and Depression in People with Fibromyalgia. 61
32368163 2020
The outcome of a temporomandibular joint compression test for the diagnosis of arthralgia is confounded by concurrent myalgia. 61
31025193 2020
[Discussion on clinical application of "touching-bone" acupuncture technique]. 61
31930900 2020
Current and Emerging Pharmacotherapy for Fibromyalgia. 61
32104521 2020
CRPS Is Not Associated with Altered Sensorimotor Cortex GABA or Glutamate. 61
31980452 2020
"I did not know it was a medical condition": Predictors, severity and help seeking behaviors of women with female sexual dysfunction in the Volta region of Ghana. 61
31929541 2020
Functional symptoms in dermatology: Part 2. 61
31468592 2020
Variations in psychiatric morbidity between traumatized Norwegian, refugees and other immigrant patients in Oslo. 61
31961250 2020
Ilioinguinal Neuropathy. 61
31960176 2020
Complex regional pain syndrome: A case report and review of the literature. 61
32174618 2020
Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder. 61
32158212 2020
Persistent dentoalveolar pain disorder: A putative intraoral chronic overlapping pain condition. 61
31797486 2019
Subtle changes of gray matter volume in fibromyalgia reflect chronic musculoskeletal pain rather than disease-specific effects. 61
31448468 2019
Approach as a key for success: Reduced avoidance behaviour mediates the effect of exposure therapy for fibromyalgia. 61
31585343 2019
Association between low back pain and various everyday performances : Activities of daily living, ability to work and sexual function. 61
31493101 2019
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits. 61
31471472 2019
Female sexual dysfunction among married women in the Gaza Strip: an internet-based survey. 61
31580717 2019

Variations for Paine Syndrome

ClinVar genetic disease variations for Paine Syndrome:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PTPRQ NM_001145026.2(PTPRQ):c.6475C>T (p.Arg2159Ter)SNV Pathogenic 523416 rs1445287184 12:81064144-81064144 12:80670365-80670365
2 OAT NM_000274.3(OAT):c.875A>G (p.Lys292Arg)SNV Likely pathogenic 374146 rs1057518927 10:126091521-126091521 10:124402952-124402952
3 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val)SNV Likely pathogenic 523328 rs1554781700 9:137593133-137593133 9:134701287-134701287
4 SCN4A NM_000334.4(SCN4A):c.1333G>T (p.Val445Leu)SNV Conflicting interpretations of pathogenicity 373945 rs121908552 17:62041947-62041947 17:63964587-63964587
5 GJB1 NM_000166.6(GJB1):c.109G>T (p.Val37Leu)SNV Conflicting interpretations of pathogenicity 374173 rs1057518946 X:70443666-70443666 X:71223816-71223816
6 MAP2K2 NM_030662.3(MAP2K2):c.514A>G (p.Lys172Glu)SNV Uncertain significance 523536 rs1413580671 19:4102388-4102388 19:4102390-4102390
7 KIF1B NM_015074.3(KIF1B):c.2473G>A (p.Glu825Lys)SNV Uncertain significance 373920 rs763122049 1:10384889-10384889 1:10324831-10324831
8 SELENON NM_020451.3(SELENON):c.482G>A (p.Arg161Gln)SNV Uncertain significance 373919 rs765749301 1:26131711-26131711 1:25805220-25805220

Expression for Paine Syndrome

Search GEO for disease gene expression data for Paine Syndrome.

Pathways for Paine Syndrome

Pathways related to Paine Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
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11.72 SCN9A SCN3A P2RX3
Show member pathways

GO Terms for Paine Syndrome

Cellular components related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.77 TRPV1 PNOC OPRM1 NGF BDNF
2 neuron projection GO:0043005 9.72 TRPV1 SCN9A P2RX3 OPRM1 CALCA
3 neuronal cell body GO:0043025 9.7 TRPV1 TAC1 SCN1A PNOC P2RX3 GAL
4 integral component of presynaptic membrane GO:0099056 9.43 SCN10A P2RX3 OPRM1
5 stereocilium bundle GO:0032421 9.4 TRPA1 PTPRQ
6 axon GO:0030424 9.36 TAC1 SCN9A SCN3A SCN1A SCN11A SCN10A
7 voltage-gated sodium channel complex GO:0001518 9.35 SCN9A SCN3A SCN1A SCN11A SCN10A

Biological processes related to Paine Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.07 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN11A
2 ion transport GO:0006811 10.03 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN11A
3 inflammatory response GO:0006954 10 TRPV1 TAC1 SCN9A GAL CALCA
4 response to drug GO:0042493 9.95 TRPA1 SCN11A GAL BDNF
5 ion transmembrane transport GO:0034220 9.91 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN10A
6 regulation of ion transmembrane transport GO:0034765 9.88 SCN9A SCN3A SCN1A SCN11A SCN10A
7 sodium ion transport GO:0006814 9.85 SCN9A SCN3A SCN1A SCN11A SCN10A
8 modulation of chemical synaptic transmission GO:0050804 9.8 P2RX3 NGF BDNF
9 sodium ion transmembrane transport GO:0035725 9.8 SCN9A SCN3A SCN1A SCN11A SCN10A
10 excitatory postsynaptic potential GO:0060079 9.78 TRPV1 P2RX3 OPRM1
11 response to heat GO:0009408 9.75 TRPV1 P2RX3 CALCA
12 cellular response to nerve growth factor stimulus GO:1990090 9.74 TRPV1 TAC1 CALCA
13 feeding behavior GO:0007631 9.73 GAL CALCA BDNF
14 neuropeptide signaling pathway GO:0007218 9.73 TAC1 PNOC OPRM1 NPS GAL CALCA
15 behavioral response to pain GO:0048266 9.69 TRPV1 SCN9A P2RX3
16 sensory perception GO:0007600 9.67 SCN10A PNOC OPRM1
17 neurotrophin TRK receptor signaling pathway GO:0048011 9.66 NGF BDNF
18 cellular response to ATP GO:0071318 9.65 TRPV1 P2RX3
19 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.65 TRPV1 CALCA
20 nerve development GO:0021675 9.64 NGF BDNF
21 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.64 TRPA1 SCN1A
22 nerve growth factor signaling pathway GO:0038180 9.63 NGF BDNF
23 positive regulation of synaptic transmission, GABAergic GO:0032230 9.63 TAC1 NPS
24 sensory perception of pain GO:0019233 9.63 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1
25 negative regulation of heart rate GO:0010459 9.62 TRPV1 TAC1
26 response to pain GO:0048265 9.62 TRPV1 TRPA1 TAC1 CALCA
27 positive regulation of collateral sprouting GO:0048672 9.61 NGF BDNF
28 urinary bladder smooth muscle contraction GO:0014832 9.59 TRPV1 P2RX3
29 positive regulation of action potential GO:0045760 9.58 TAC1 NPS
30 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.55 TRPV1 TRPA1
31 thermoception GO:0050955 9.54 TRPV1 TRPA1
32 membrane depolarization during action potential GO:0086010 9.35 SCN9A SCN3A SCN1A SCN11A SCN10A
33 neuronal action potential GO:0019228 9.1 SCN9A SCN3A SCN1A SCN11A SCN10A P2RX3

Molecular functions related to Paine Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.72 SCN9A SCN3A SCN1A SCN11A SCN10A
2 sodium channel activity GO:0005272 9.65 SCN9A SCN3A SCN1A SCN11A SCN10A
3 voltage-gated sodium channel activity GO:0005248 9.55 SCN9A SCN3A SCN1A SCN11A SCN10A
4 cation channel activity GO:0005261 9.43 TRPV1 SCN9A SCN3A SCN1A SCN11A SCN10A
5 calcium-release channel activity GO:0015278 9.4 TRPV1 TRPA1
6 nerve growth factor receptor binding GO:0005163 9.37 NGF BDNF
7 ion channel activity GO:0005216 9.23 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN11A

Sources for Paine Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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