MCID: PLN005
MIFTS: 44

Palindromic Rheumatism

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Palindromic Rheumatism

MalaCards integrated aliases for Palindromic Rheumatism:

Name: Palindromic Rheumatism 12 74 52 43 15 71 32
Hench-Rosenberg Syndrome 12 52
Hench's Syndrome 12 52
Palindromic Rheumatism Syndrome 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1166
MeSH 43 C538103
SNOMED-CT 67 50442003
ICD10 32 M12.3 M12.30
UMLS 71 C0085574 C0158178

Summaries for Palindromic Rheumatism

NIH Rare Diseases : 52 Palindromic rheumatism (PR) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. A PR attack often occurs suddenly without any obvious triggers or warning symptoms. Any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. Symptoms during episodes may include pain, swelling, stiffness, and redness in and around the joints. Some people may have a fever and other systemic symptoms. Between episodes, people with PR have no symptoms. The time between episodes may last from days to months. The underlying cause of PR is not known. Some people with PR eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (RA). Others may develop lupus and/or other systemic disorders. People with anti-CCP antibodies detected in a blood test appear more likely to develop RA. There has been some evidence to support that PR can be a presenting feature of RA (or part of the spectrum of RA), rather than a distinct condition. Treatment of PR is challenging, as it has not been studied in randomized trials. Nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to treat acute episodes. Disease-modifying antirheumatic drugs (DMARDs) may be an option for those with refractory, frequent attacks. Hydroxychloroquine (a DMARD) reportedly may help control attacks and reduce the risk of progression to RA.

MalaCards based summary : Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to enthesopathy and intermittent hydrarthrosis, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV Innate Immuity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Abatacept and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia : 74 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 enthesopathy 31.6 TNFRSF1B TNF MEFV
2 intermittent hydrarthrosis 30.7 TNFRSF1A MEFV
3 tenosynovitis 30.2 TNFRSF1B TNF
4 pustulosis of palm and sole 30.2 TNFRSF1B TNF
5 vasculitis 30.1 TNFRSF1B TNF MEFV
6 spondylarthropathy 29.9 TNFRSF1A TNF
7 rheumatic disease 29.9 TNFRSF1B TNF PADI4 MEFV IL1B HLA-DRB1
8 gout 29.6 TNF MEFV IL1B
9 lupus erythematosus 29.6 TNFRSF1B TNF PTPN22 HLA-DRB1
10 synovitis 29.6 TNFRSF1A TNF IL1B
11 uveitis 29.6 TNFRSF1B TNFRSF1A TNF
12 connective tissue disease 29.5 TNFRSF1B TNF IL1B HLA-DRB1
13 familial mediterranean fever 29.2 TNFRSF1A TNF MEFV IL1B
14 juvenile rheumatoid arthritis 28.6 TNFRSF1B TNFRSF1A TNF IL1B HLA-DRB1
15 crohn's disease 28.4 TNFRSF1B TNF PTPN22 IL1B HLA-DRB1
16 rheumatoid arthritis 28.2 TNFRSF1B TNFRSF1A TNF PTPN22 PADI4 IL1B
17 autoimmune disease 28.0 TNFRSF1B TNF PTPN22 PADI4 IL1B HLA-DRB1
18 arthritis 27.7 TNFRSF1B TNFRSF1A TNF PTPN22 PADI4 MEFV
19 psoriasis 27.7 TNFRSF1B TNFRSF1A TNF PTPN22 IL1B HLA-DRB1
20 systemic lupus erythematosus 27.6 TNFRSF1B TNFRSF1A TNF PTPN22 PADI4 IL1B
21 arthropathy 10.3
22 rheumatoid factor-negative juvenile idiopathic arthritis 10.3 PTPN22 HLA-DRB1
23 periarthritis 10.3
24 hydrarthrosis 10.3
25 ocular cicatricial pemphigoid 10.3 TNFRSF1B HLA-DRB1
26 microscopic polyangiitis 10.2 TNF HLA-DRB1
27 beryllium disease 10.2 TNF HLA-DRB1
28 chronic beryllium disease 10.2 TNF HLA-DRB1
29 nontuberculous mycobacterial lung disease 10.2 TNF HLA-DRB1
30 rheumatoid vasculitis 10.2 TNF HLA-DRB1
31 inflammatory myopathy with abundant macrophages 10.2 TNFRSF1A MEFV
32 idiopathic recurrent pericarditis 10.2 TNFRSF1A MEFV
33 skin sarcoidosis 10.2 TNFRSF1B TNF
34 necrobiosis lipoidica 10.2 TNFRSF1B TNF
35 opportunistic bacterial infectious disease 10.2 TNFRSF1B TNF
36 nocardiosis 10.2 TNFRSF1B TNF
37 neurosarcoidosis 10.2 TNFRSF1B TNF
38 aortitis 10.2 TNFRSF1B TNF
39 hypersensitivity reaction type iii disease 10.2 TNF MEFV
40 granulomatous dermatitis 10.1 TNFRSF1B TNF
41 chondromalacia 10.1 TNFRSF1B TNF
42 scleral disease 10.1 TNFRSF1B TNF
43 bursitis 10.1 TNFRSF1B TNF
44 familial cold autoinflammatory syndrome 1 10.1 TNFRSF1A MEFV
45 uveoparotid fever 10.1 TNFRSF1B TNF
46 good syndrome 10.1 TNFRSF1B TNF
47 erysipelas 10.1 TNF MEFV
48 iritis 10.1 TNFRSF1B TNF
49 miliary tuberculosis 10.1 TNFRSF1B TNF
50 alveolar echinococcosis 10.1 TNF HLA-DRB1

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to Palindromic Rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

MGI Mouse Phenotypes related to Palindromic Rheumatism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 IL1B MEFV PADI4 PTPN22 TNF TNFRSF1A
2 immune system MP:0005387 9.5 IL1B MEFV PADI4 PTPN22 TNF TNFRSF1A
3 liver/biliary system MP:0005370 9.02 MEFV PTPN22 TNF TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Palindromic Rheumatism

Drugs for Palindromic Rheumatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2 Pharmaceutical Solutions Phase 4
3 Antirheumatic Agents Phase 4
4 Immunosuppressive Agents Phase 4
5 Immunologic Factors Phase 4
6
Hydroxychloroquine Approved 118-42-3 3652
7 Anti-Infective Agents
8 Antiprotozoal Agents
9 Antiparasitic Agents
10 Antimalarials

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 EFFECTS OF ABATACEPT ON THE PROGRESSION TO RHEUMATOID ARTHRITIS IN PATIENTS WITH PALINDROMIC RHEUMATISM (PALABA) Not yet recruiting NCT03669367 Phase 4 Abatacept Injection;hydroxycloroquina
2 Cytochrome P450 and ATP-Binding Cassette C C (ABCC) Variants in Egyptian Patients Receiving Hydroxychloroquine and Their Association With Efficacy and Toxicity Unknown status NCT03180190 Hydroxychloroquine Oral Tablet

Search NIH Clinical Center for Palindromic Rheumatism

Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

MalaCards organs/tissues related to Palindromic Rheumatism:

40
Testes, Bone, Lung, Heart, Thyroid, Bone Marrow, Eye

Publications for Palindromic Rheumatism

Articles related to Palindromic Rheumatism:

(show top 50) (show all 217)
# Title Authors PMID Year
1
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. 61 52
26235245 2015
2
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up. 61 52
24623460 2014
3
Factors determining response to Hydroxychloroquine therapy in palindromic rheumatism. 61
31979694 2020
4
The evaluation of gene polymorphisms associated with autoinflammatory syndrome in patients with palindromic rheumatism complicated by intermittent hydrarthrosis. 61
31897954 2020
5
Palindromic Rheumatism Frequently Precedes Early Rheumatoid Arthritis: Results From an Incident Cohort. 61
31872182 2019
6
Palindromic rheumatism as part of the rheumatoid arthritis continuum. 61
31595059 2019
7
Efficacy of rituximab in resistant palindromic rheumatism: first report in literature. 61
31076945 2019
8
Expression of a PYCARD/ASC variant lacking exon 2 in Japanese patients with palindromic rheumatism increases interleukin-1β secretion. 61
31421660 2019
9
Rheumatoid Arthritis Initiating as Palindromic Rheumatism: A Distinct Clinical Phenotype? 61
31371648 2019
10
Relapsing periodic arthritis, palindromic rheumatism and MEFV gene-related variants alleles in children. 61
31171010 2019
11
Is Palindromic Rheumatism a Pre-rheumatoid Arthritis Condition? Low Incidence of Rheumatoid Arthritis in Palindromic Rheumatism Patients Treated with Tight Control Strategy. 61
30987884 2019
12
Identification of a distinct imaging phenotype may improve the management of palindromic rheumatism. 61
30297331 2019
13
Response to: 'Ultrasound findings in palindromic rheumatism' by Sanmarti et al. 61
30578295 2018
14
Utility of power Doppler ultrasonography for detecting forefoot bursae in early rheumatoid arthritis: A case report. 61
30572433 2018
15
Ultrasound findings in palindromic rheumatism. 61
30552178 2018
16
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. 61
26457478 2018
17
Is palindromic rheumatism amongst children a benign disease? 61
29439723 2018
18
Risk of autoimmune rheumatic diseases in patients with palindromic rheumatism: A nationwide, population-based, cohort study. 61
30048527 2018
19
Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis. 61
28619044 2017
20
Widespread subcutaneous necrosis in spotted fever group Rickettsioses from the coastal belt of Sri Lanka- a case report. 61
28412927 2017
21
Symptoms in individuals at risk of rheumatoid arthritis. 61
29221599 2017
22
What can palindromic rheumatism tell us? 61
29221602 2017
23
Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study. 61
28771535 2017
24
Palindromic Rheumatism-Like Migratory Non-Erosive Seronegative Polyarthritis in a Patient With Metastatic Conjunctival Malignant Melanoma. 61
29900944 2016
25
Anti-citrullinated peptide/protein antibodies in palindromic rheumatism: comment on the article by Emad Y et al. 61
24797773 2015
26
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? a clinical and ultrasonographic study according to anticitrullinated protein antibody status. 61
25028368 2014
27
[Palindromic rheumatism or incipient rheumatoid arthritis--chances of drug therapy]. 61
25558613 2014
28
Palindromic rheumatism: consider Whipple's disease. 61
23992271 2013
29
[Palindromic rheumatism]. 61
22939655 2013
30
Hand surgery for Multicentric Reticulohistiocytosis: A new avenue of treatment and review of the literature. 61
23796955 2013
31
Palindromic rheumatism: a pre-rheumatoid arthritis state? 61
23028026 2012
32
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. 61
22859345 2012
33
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. 61
22898224 2012
34
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. 61
22665157 2012
35
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. 61
22536266 2012
36
An evaluation of the impact of seniors on a rheumatology referral clinic: demographics and pharmacotherapy. 61
21935585 2011
37
Palindromic rheumatism. 61
21206416 2011
38
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. 61
20808171 2010
39
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. 61
20476860 2010
40
[Palindromic rheumatism. Report of one case]. 61
21043081 2010
41
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. 61
19771490 2010
42
The spectrum of MEFV clinical presentations--is it familial Mediterranean fever only? 61
19837680 2009
43
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. 61
19710217 2009
44
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. 61
19648311 2009
45
[Diagnostic utility of AxSYM anti-cyclic Citrullinated peptide antibody assay]. 61
19127111 2008
46
Magnetic resonance imaging of palindromic rheumatism. 61
18663450 2008
47
MEFV mutations and palindromic rheumatism: comment on the article by Cañete et al. 61
18512803 2008
48
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. 61
18412310 2008
49
Peripheral inflammatory arthritis in patients with chronic periaortitis: report of five cases and review of the literature. 61
18218649 2008
50
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? 61
18290263 2007

Variations for Palindromic Rheumatism

Expression for Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for Palindromic Rheumatism

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 TNFRSF1B TNFRSF1A TNF PTPN22 MEFV IL1B
2
Show member pathways
13.17 TNFRSF1B TNFRSF1A TNF IL1B HLA-DRB1
3
Show member pathways
13.1 TNFRSF1B TNFRSF1A TNF PTPN22 IL1B
4
Show member pathways
12.76 TNFRSF1B TNFRSF1A TNF IL1B
5
Show member pathways
12.64 TNFRSF1A TNF IL1B HLA-DRB1
6 12.62 TNFRSF1A TNF IL1B HLA-DRB1
7
Show member pathways
12.52 TNFRSF1B TNFRSF1A TNF IL1B
8
Show member pathways
12.45 TNFRSF1B TNFRSF1A TNF IL1B
9
Show member pathways
12.43 TNFRSF1B TNFRSF1A TNF HLA-DRB1
10
Show member pathways
12.36 TNFRSF1B TNFRSF1A TNF IL1B
11 12.24 TNFRSF1A TNF IL1B
12 12.2 TNFRSF1A TNF HLA-DRB1
13
Show member pathways
12.19 TNFRSF1B TNFRSF1A TNF
14
Show member pathways
12.18 TNFRSF1B TNFRSF1A TNF
15 12.15 TNFRSF1A TNF IL1B
16 12.1 TNFRSF1B TNFRSF1A TNF
17 12.08 TNF MEFV IL1B
18
Show member pathways
12.06 TNFRSF1A TNF IL1B
19
Show member pathways
11.98 TNFRSF1A TNF IL1B HLA-DRB1
20 11.94 TNFRSF1A TNF IL1B
21 11.92 TNFRSF1A TNF IL1B HLA-DRB1
22 11.89 TNFRSF1A TNF IL1B
23 11.87 TNFRSF1B TNFRSF1A TNF PTPN22 IL1B
24 11.86 TNF MEFV IL1B
25 11.82 TNFRSF1B TNF IL1B
26
Show member pathways
11.82 TNFRSF1B TNFRSF1A TNF
27 11.75 TNFRSF1A TNF IL1B
28 11.73 TNF IL1B HLA-DRB1
29 11.68 TNF IL1B HLA-DRB1
30
Show member pathways
11.55 TNFRSF1B TNFRSF1A TNF
31 11.51 TNFRSF1B TNFRSF1A TNF
32 11.51 TNFRSF1B TNFRSF1A TNF IL1B
33
Show member pathways
11.45 TNFRSF1A TNF IL1B
34 11.37 TNFRSF1B TNFRSF1A TNF
35
Show member pathways
11.31 TNFRSF1B TNFRSF1A TNF
36 11.27 TNF IL1B
37 11.24 TNF IL1B
38 11.21 TNFRSF1B TNFRSF1A
39 11.2 TNF IL1B
40 11.18 TNF IL1B
41 11.16 TNFRSF1B TNFRSF1A
42 11.02 TNFRSF1A TNF
43 11 TNFRSF1B TNFRSF1A TNF
44 10.99 TNF IL1B
45 10.9 TNF IL1B HLA-DRB1
46 10.83 TNF IL1B
47 10.61 TNFRSF1B TNFRSF1A TNF IL1B

GO Terms for Palindromic Rheumatism

Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.13 TNFRSF1B TNFRSF1A TNF
2 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1B TNFRSF1A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.93 TNFRSF1B TNF IL1B HLA-DRB1
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 TNFRSF1A TNF IL1B
3 cytokine-mediated signaling pathway GO:0019221 9.83 TNFRSF1B TNFRSF1A TNF IL1B
4 cellular response to lipopolysaccharide GO:0071222 9.82 TNFRSF1B TNF IL1B
5 response to lipopolysaccharide GO:0032496 9.82 TNFRSF1B PTPN22 IL1B
6 negative regulation of inflammatory response GO:0050728 9.77 TNFRSF1B TNFRSF1A MEFV
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.76 TNFRSF1B TNFRSF1A TNF
8 positive regulation of inflammatory response GO:0050729 9.71 TNFRSF1A TNF IL1B
9 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.67 TNF IL1B
10 positive regulation of interleukin-6 secretion GO:2000778 9.67 TNF IL1B
11 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.67 TNFRSF1A TNF
12 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.66 TNFRSF1A TNF
13 negative regulation of neurogenesis GO:0050768 9.66 TNF IL1B
14 positive regulation of interleukin-8 production GO:0032757 9.65 TNF IL1B
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 TNF IL1B
16 negative regulation of cardiac muscle hypertrophy GO:0010614 9.63 TNFRSF1B TNFRSF1A
17 positive regulation of glial cell proliferation GO:0060252 9.62 TNF IL1B
18 negative regulation of lipid catabolic process GO:0050995 9.62 TNF IL1B
19 astrocyte activation GO:0048143 9.61 TNF IL1B
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B
21 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.6 TNF IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL1B
23 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 TNFRSF1B TNFRSF1A TNF
24 positive regulation of ceramide biosynthetic process GO:2000304 9.57 TNFRSF1A TNF
25 positive regulation of chemokine biosynthetic process GO:0045080 9.56 TNF IL1B
26 death-inducing signaling complex assembly GO:0071550 9.55 TNFRSF1A TNF
27 inflammatory response GO:0006954 9.55 TNFRSF1B TNFRSF1A TNF MEFV IL1B
28 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
29 aortic valve development GO:0003176 9.49 TNFRSF1B TNFRSF1A
30 sequestering of triglyceride GO:0030730 9.48 TNF IL1B
31 negative regulation of extracellular matrix constituent secretion GO:0003332 9.46 TNFRSF1B TNFRSF1A
32 pulmonary valve development GO:0003177 9.43 TNFRSF1B TNFRSF1A
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 TNF PTPN22 IL1B
34 positive regulation of apoptotic process involved in morphogenesis GO:1902339 9.37 TNFRSF1B TNFRSF1A
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IL1B
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.13 TNFRSF1B TNF IL1B
37 regulation of establishment of endothelial barrier GO:1903140 8.8 TNFRSF1A TNF IL1B

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1B TNFRSF1A
2 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1B TNFRSF1A

Sources for Palindromic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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