MCID: PLN005
MIFTS: 51

Palindromic Rheumatism

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Palindromic Rheumatism

MalaCards integrated aliases for Palindromic Rheumatism:

Name: Palindromic Rheumatism 12 76 53 44 15 73
Hench-Rosenberg Syndrome 12 53
Hench's Syndrome 12 53
Palindromic Rheumatism Syndrome 53

Classifications:



External Ids:

Disease Ontology 12 DOID:1166
ICD10 33 M12.3 M12.30
MeSH 44 C538103
SNOMED-CT 68 50442003

Summaries for Palindromic Rheumatism

NIH Rare Diseases : 53 Palindromic rheumatism (PR) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. A PR attack often occurs suddenly without any obvious triggers or warning symptoms. Any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. Symptoms during episodes may include pain, swelling, stiffness, and redness in and around the joints. Some people may have a fever and other systemic symptoms. Between episodes, people with PR have no symptoms. The time between episodes may last from days to months. The underlying cause of PR is not known. Some people with PR eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (RA). Others may develop lupus and/or other systemic disorders. People with anti-CCP antibodies detected in a blood test appear more likely to develop RA. There has been some evidence to support that PR can be a presenting feature of RA (or part of the spectrum of RA), rather than a distinct condition.  Treatment of PR is challenging, as it has not been studied in randomized trials.Nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to treat acute episodes. Disease-modifying antirheumatic drugs (DMARDs) may be an option for those with refractory, frequent attacks.Hydroxychloroquine (a DMARD) reportedly may help control attacks and reduce the risk of progression to RA.

MalaCards based summary : Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to arthritis and synovitis, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Abatacept and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia : 76 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 arthritis 31.0 HLA-DRB1 IL1B PTPN22 TNF TNFRSF1B
2 synovitis 30.5 CRP IL1B TNF
3 rheumatoid arthritis 30.2 CRP HLA-DRB1 IL1B PADI4 PRTN3 PTPN22
4 periodontitis 30.1 CRP IL1B TNF
5 polyarteritis nodosa 30.0 CRP MEFV PRTN3
6 rheumatic disease 30.0 CRP HLA-DRB1 IL1B PADI4 TNF
7 familial mediterranean fever 30.0 CRP IL1B MEFV TNF TNFRSF1A
8 juvenile rheumatoid arthritis 29.9 CRP HLA-DRB1 IL1B TNF TNFRSF1B
9 systemic lupus erythematosus 29.6 CRP HLA-DRB1 IL1B PRTN3 PTPN22 TNF
10 enthesopathy 10.5
11 inflammatory myopathy with abundant macrophages 10.3 MEFV TNFRSF1A
12 intermittent hydrarthrosis 10.3 MEFV TNFRSF1A
13 mesial temporal lobe epilepsy with hippocampal sclerosis 10.3 HLA-DRB1 IL1B
14 exudative glomerulonephritis 10.3 IL1B TNF
15 rheumatoid factor-negative juvenile idiopathic arthritis 10.3 HLA-DRB1 PTPN22
16 systemic onset juvenile idiopathic arthritis 10.3 MEFV TNF
17 postherpetic neuralgia 10.3 HLA-A HLA-DRB1
18 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
19 staphylococcal toxic shock syndrome 10.2 IL1B TNF
20 idiopathic recurrent pericarditis 10.2 MEFV TNFRSF1A
21 familial cold autoinflammatory syndrome 1 10.2 IL1B MEFV TNFRSF1A
22 microscopic polyangiitis 10.2 HLA-DRB1 TNF
23 stomatitis 10.2 IL1B MEFV TNF
24 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DRB1 PTPN22 TNF
25 actinic prurigo 10.2 HLA-DRB1 IL1B TNF
26 blau syndrome 10.2 IL1B MEFV TNF
27 beryllium disease 10.2 HLA-DRB1 TNF
28 idiopathic neutropenia 10.2 HLA-DRB1 IL1B TNF
29 skin sarcoidosis 10.2 TNF TNFRSF1B
30 chronic gonococcal salpingitis 10.2 TNF TNFRSF1A TNFRSF1B
31 mumps 10.2 HLA-DRB1 TNF TNFRSF1A
32 rheumatoid lung disease 10.2 IL1B TNF TNFRSF1B
33 chronic salpingitis 10.2 TNF TNFRSF1A TNFRSF1B
34 autoimmune disease of central nervous system 10.2 HLA-DRB1 IL1B TNF
35 drug reaction with eosinophilia and systemic symptoms 10.2 CRP TNF
36 caplan's syndrome 10.2 HLA-A TNFRSF10A
37 autoimmune disease of the nervous system 10.2 HLA-DRB1 IL1B TNF
38 nontuberculous mycobacterial lung disease 10.2 HLA-A HLA-DRB1 TNF
39 alveolar echinococcosis 10.2 HLA-A HLA-DRB1 TNF
40 guillain-barre syndrome 10.2 TNF TNFRSF1A TNFRSF1B
41 anterior uveitis 10.2 HLA-A PTPN22 TNF
42 vogt-koyanagi-harada disease 10.2 HLA-A HLA-DRB1 PTPN22
43 dengue hemorrhagic fever 10.2 HLA-A HLA-DRB1 TNF
44 pharyngitis 10.2 CRP IL1B MEFV
45 bacterial infectious disease 10.2 CRP IL1B TNF
46 hypersensitivity reaction type iii disease 10.2 CRP MEFV TNF
47 conjunctival disease 10.2 MRAP TNF TNFRSF1A
48 scleral disease 10.2 MRAP TNF TNFRSF1B
49 pustulosis of palm and sole 10.2 MRAP TNF TNFRSF1B
50 granulomatous dermatitis 10.2 TNF TNFRSF1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to Palindromic Rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

MGI Mouse Phenotypes related to Palindromic Rheumatism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 IL1B LAIR1 MEFV PADI4 PRTN3 PTPN22
2 immune system MP:0005387 9.77 AGBL2 CRP ERBB3 IL1B LAIR1 MEFV
3 neoplasm MP:0002006 9.1 ERBB3 IL1B TNF TNFRSF10A TNFRSF1A TNFRSF1B

Drugs & Therapeutics for Palindromic Rheumatism

Drugs for Palindromic Rheumatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2 Antirheumatic Agents Phase 4
3 Pharmaceutical Solutions Phase 4
4 Immunologic Factors Phase 4
5 Immunosuppressive Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 EFFECTS OF ABATACEPT on the Progression to Rheumatoid Arthritis(PALABA Study) Not yet recruiting NCT03669367 Phase 4 Abatacept Injection;hydroxycloroquina

Search NIH Clinical Center for Palindromic Rheumatism

Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

MalaCards organs/tissues related to Palindromic Rheumatism:

41
Testes, Bone, Lung, Heart, Skin, Lymph Node, Temporal Lobe

Publications for Palindromic Rheumatism

Articles related to Palindromic Rheumatism:

(show top 50) (show all 127)
# Title Authors Year
1
Is palindromic rheumatism amongst children a benign disease? ( 29439723 )
2018
2
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2018
3
Risk of autoimmune rheumatic diseases in patients with palindromic rheumatism: A nationwide, population-based, cohort study. ( 30048527 )
2018
4
Identification of a distinct imaging phenotype may improve the management of palindromic rheumatism. ( 30297331 )
2018
5
Ultrasound findings in palindromic rheumatism. ( 30552178 )
2018
6
Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis. ( 28619044 )
2017
7
Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study. ( 28771535 )
2017
8
What can palindromic rheumatism tell us? ( 29221602 )
2017
9
Palindromic Rheumatism-Like Migratory Non-Erosive Seronegative Polyarthritis in a Patient With Metastatic Conjunctival Malignant Melanoma. ( 29900944 )
2016
10
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. ( 26235245 )
2015
11
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. ( 24623460 )
2014
12
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. ( 25028368 )
2014
13
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. ( 24797773 )
2014
14
Palindromic rheumatism: consider Whipple's disease. ( 23992271 )
2013
15
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. ( 22898224 )
2012
16
Palindromic rheumatism: a pre-rheumatoid arthritis state? ( 23028026 )
2012
17
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. ( 22859345 )
2012
18
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. ( 22665157 )
2012
19
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. ( 22536266 )
2012
20
Palindromic rheumatism. ( 21206416 )
2011
21
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. ( 19771490 )
2010
22
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. ( 20476860 )
2010
23
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. ( 20808171 )
2010
24
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. ( 19710217 )
2009
25
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. ( 19648311 )
2009
26
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. ( 18412310 )
2008
27
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. ( 18512803 )
2008
28
Magnetic resonance imaging of palindromic rheumatism. ( 18663450 )
2008
29
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. ( 17763205 )
2007
30
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? ( 18290263 )
2007
31
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. ( 17665427 )
2007
32
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. ( 17187097 )
2006
33
Short term palindromic rheumatism after clopidogrel use. ( 16611878 )
2006
34
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. ( 16724377 )
2006
35
Palindromic rheumatism: different genetic background implies a distinct disease entity. ( 17038462 )
2006
36
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. ( 16847371 )
2006
37
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. ( 16189657 )
2005
38
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. ( 15290752 )
2004
39
Palindromic rheumatism and other relapsing arthritis. ( 15454124 )
2004
40
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? ( 12730510 )
2003
41
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. ( 12415587 )
2002
42
Palindromic rheumatism. ( 12408287 )
2002
43
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. ( 24387063 )
2002
44
A patient with severe palindromic rheumatism and frequent episodes of pain. ( 11300148 )
2001
45
Palindromic rheumatism: effect of dietary manipulation. ( 10895376 )
2000
46
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. ( 10648016 )
2000
47
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. ( 10090159 )
1999
48
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. ( 10063316 )
1999
49
Sparing effect of hemiparesis on palindromic rheumatism. ( 9093804 )
1997
50
Remission in palindromic rheumatism during pregnancy. ( 8478889 )
1993

Variations for Palindromic Rheumatism

Expression for Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for Palindromic Rheumatism

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CRP DYNLT1 ERBB3 HLA-A HLA-DRB1 IL1B
2
Show member pathways
13.32 ERBB3 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
3
Show member pathways
13.21 ERBB3 HLA-A HLA-DRB1 IL1B PRTN3 TNF
4
Show member pathways
13.2 IL1B PTPN22 TNF TNFRSF10A TNFRSF10B TNFRSF1A
5
Show member pathways
12.74 HLA-A HLA-DRB1 IL1B TNF TNFRSF1A TNFRSF1B
6
Show member pathways
12.72 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7
Show member pathways
12.44 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
8
Show member pathways
12.43 HLA-A TNF TNFRSF10A TNFRSF10B
9
Show member pathways
12.41 ERBB3 TNF TNFRSF1A TNFRSF1B
10 12.33 HLA-A HLA-DRB1 TNF TNFRSF1A
11
Show member pathways
12.16 HLA-DRB1 IL1B TNF TNFRSF1A
12 12.15 IL1B PTPN22 TNF TNFRSF10B TNFRSF1A TNFRSF1B
13
Show member pathways
12.13 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
14 12.11 HLA-DRB1 IL1B TNF TNFRSF1A
15 11.99 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
16
Show member pathways
11.95 IL1B TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
17
Show member pathways
11.89 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
18
Show member pathways
11.86 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
19 11.81 HLA-DRB1 IL1B TNF
20 11.8 IL1B TNF TNFRSF1A TNFRSF1B
21 11.79 IL1B TNF TNFRSF1A
22 11.76 HLA-DRB1 IL1B TNF
23
Show member pathways
11.65 TNF TNFRSF1A TNFRSF1B
24 11.62 TNF TNFRSF1A TNFRSF1B
25
Show member pathways
11.57 IL1B TNF TNFRSF1A
27 11.48 TNF TNFRSF1A TNFRSF1B
28
Show member pathways
11.42 TNF TNFRSF1A TNFRSF1B
29 11.19 TNF TNFRSF1A TNFRSF1B
30 11.12 HLA-DRB1 IL1B TNF
31 10.95 IL1B TNF TNFRSF1A TNFRSF1B
32 10.86 IL1B TNF

GO Terms for Palindromic Rheumatism

Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.46 PRTN3 TNF TNFRSF1A TNFRSF1B
2 cell surface GO:0009986 9.43 HLA-A HLA-DRB1 TNF TNFRSF10A TNFRSF10B TNFRSF1A
3 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.96 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 ERBB3 IL1B PTPN22 TNF
3 leukocyte migration GO:0050900 9.91 IL1B TNF TNFRSF10A TNFRSF10B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B TNF TNFRSF10B TNFRSF1A
5 negative regulation of inflammatory response GO:0050728 9.84 MEFV TNFRSF1A TNFRSF1B
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.83 TNF TNFRSF10A TNFRSF10B
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNF TNFRSF1A TNFRSF1B
8 cytokine-mediated signaling pathway GO:0019221 9.8 IL1B PRTN3 TNF TNFRSF1A TNFRSF1B
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 TNF TNFRSF1A TNFRSF1B
10 extrinsic apoptotic signaling pathway GO:0097191 9.73 TNF TNFRSF10A TNFRSF1B
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 IL1B PTPN22 TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 IL1B TNF
13 negative regulation of lipid storage GO:0010888 9.64 CRP TNF
14 positive regulation of ceramide biosynthetic process GO:2000304 9.63 TNF TNFRSF1A
15 death-inducing signaling complex assembly GO:0071550 9.62 TNF TNFRSF1A
16 positive regulation of chemokine biosynthetic process GO:0045080 9.62 IL1B TNF
17 cellular response to mechanical stimulus GO:0071260 9.62 IL1B TNFRSF10A TNFRSF10B TNFRSF1A
18 positive regulation of neuroinflammatory response GO:0150078 9.6 IL1B TNF
19 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
20 TRAIL-activated apoptotic signaling pathway GO:0036462 9.57 TNFRSF10A TNFRSF10B
21 aortic valve development GO:0003176 9.55 TNFRSF1A TNFRSF1B
22 chronic inflammatory response to antigenic stimulus GO:0002439 9.54 IL1B TNF
23 negative regulation of neurogenesis GO:0050768 9.54 DYNLT1 IL1B TNF
24 negative regulation of extracellular matrix constituent secretion GO:0003332 9.52 TNFRSF1A TNFRSF1B
25 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
26 positive regulation of apoptotic process involved in morphogenesis GO:1902339 9.48 TNFRSF1A TNFRSF1B
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
28 pulmonary valve development GO:0003177 9.43 TNFRSF1A TNFRSF1B
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 IL1B TNF TNFRSF1B
30 regulation of establishment of endothelial barrier GO:1903140 9.33 IL1B TNF TNFRSF1A
31 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.26 TNF TNFRSF10A TNFRSF10B TNFRSF1A
32 inflammatory response GO:0006954 9.17 CRP IL1B LXN MEFV TNF TNFRSF1A
33 immune system process GO:0002376 10.06 HLA-A HLA-DRB1 LAIR1 MEFV PTPN22
34 immune response GO:0006955 10.04 HLA-A HLA-DRB1 IL1B TNF TNFRSF1B
35 positive regulation of gene expression GO:0010628 10.01 CRP ERBB3 IL1B PTPN22 TNF

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 CRP DYNLT1 ERBB3 HLA-A IL1B LAIR1
2 tumor necrosis factor-activated receptor activity GO:0005031 9.26 TNFRSF1A TNFRSF1B
3 TRAIL binding GO:0045569 9.16 TNFRSF10A TNFRSF10B
4 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B

Sources for Palindromic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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