Aliases & Classifications for Palindromic Rheumatism

MalaCards integrated aliases for Palindromic Rheumatism:

Name: Palindromic Rheumatism 12 76 53 44 15 73
Hench-Rosenberg Syndrome 12 53
Hench's Syndrome 12 53
Palindromic Rheumatism Syndrome 53

Classifications:



External Ids:

Disease Ontology 12 DOID:1166
ICD10 33 M12.3 M12.30
MeSH 44 C538103

Summaries for Palindromic Rheumatism

NIH Rare Diseases : 53 Palindromic rheumatism (PR) is a type of recurrent arthritis characterized by episodes or "attacks" of joint inflammation, sequentially affecting one to several joint areas for hours to days. A PR attack often occurs suddenly without any obvious triggers or warning symptoms. Any joint(s) may be affected, but finger joints, wrists, and knees are most commonly affected. Symptoms during episodes may include pain, swelling, stiffness, and redness in and around the joints. Some people may have a fever and other systemic symptoms. Between episodes, people with PR have no symptoms. The time between episodes may last from days to months. The underlying cause of PR is not known. Some people with PR eventually develop chronic rheumatic disease, the most common being rheumatoid arthritis (RA). Others may develop lupus and/or other systemic disorders. People with anti-CCP antibodies detected in a blood test appear more likely to develop RA. There has been some evidence to support that PR can be a presenting feature of RA (or part of the spectrum of RA), rather than a distinct condition.  Treatment of PR is challenging, as it has not been studied in randomized trials.Nonsteroidal anti-inflammatory drugs (NSAIDs) may be used to treat acute episodes. Disease-modifying antirheumatic drugs (DMARDs) may be an option for those with refractory, frequent attacks.Hydroxychloroquine (a DMARD) reportedly may help control attacks and reduce the risk of progression to RA.

MalaCards based summary : Palindromic Rheumatism, also known as hench-rosenberg syndrome, is related to arthritis and synovitis, and has symptoms including arthralgia, other symptoms referable to joint and stiffness of joint, not elsewhere classified in icd10cm. An important gene associated with Palindromic Rheumatism is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include testes, neutrophil and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms.

Wikipedia : 76 Palindromic rheumatism (PR) consists of sudden and rapidly developing attacks of arthritis. There is... more...

Related Diseases for Palindromic Rheumatism

Diseases related to Palindromic Rheumatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.9 HLA-DRB1 IL1B PTPN22 TNF TNFRSF1B
2 synovitis 30.5 CRP IL1B TNF
3 brucellosis 30.3 CRP MEFV TNF
4 periodontitis 30.1 CRP IL1B TNF
5 familial mediterranean fever 29.6 CRP IL1B MEFV TNF TNFRSF1A
6 polyarteritis nodosa 29.4 CRP MEFV PRTN3
7 systemic lupus erythematosus 28.2 CRP HLA-DRB1 PRTN3 PTPN22 TNF TNFRSF1B
8 rheumatoid arthritis 27.8 CRP HLA-DRB1 IL1B PADI4 PRTN3 PTPN22
9 inflammatory myopathy with abundant macrophages 11.0 MEFV TNFRSF1A
10 intermittent hydrarthrosis 11.0 MEFV TNFRSF1A
11 rheumatoid factor-negative juvenile idiopathic arthritis 10.9 HLA-DRB1 PTPN22
12 autoimmune addison disease 10.8 HLA-DRB1 PTPN22
13 idiopathic recurrent pericarditis 10.8 MEFV TNFRSF1A
14 autoinflammation, panniculitis, and dermatosis syndrome 10.8 MEFV TNF
15 postherpetic neuralgia 10.8 HLA-A HLA-DRB1
16 microscopic polyangiitis 10.8 HLA-DRB1 TNF
17 staphylococcal toxic shock syndrome 10.8 IL1B TNF
18 familial cold autoinflammatory syndrome 1 10.7 IL1B MEFV TNFRSF1A
19 autoimmune myocarditis 10.7 IL1B TNF
20 skin sarcoidosis 10.7 TNF TNFRSF1B
21 oligoarticular juvenile idiopathic arthritis 10.7 HLA-DRB1 PTPN22 TNF
22 systemic onset juvenile idiopathic arthritis 10.7 IL1B MEFV TNF
23 actinic prurigo 10.7 HLA-DRB1 IL1B TNF
24 beryllium disease 10.7 HLA-DRB1 TNF
25 blau syndrome 10.7 IL1B MEFV TNF
26 idiopathic neutropenia 10.6 HLA-DRB1 IL1B TNF
27 kashin-beck disease 10.6 IL1B TNF
28 chronic gonococcal salpingitis 10.6 TNF TNFRSF1A TNFRSF1B
29 mumps 10.6 HLA-DRB1 TNF TNFRSF1A
30 rheumatoid lung disease 10.6 TNF TNFRSF1B
31 caplan's syndrome 10.6 HLA-A TNFRSF10A
32 chronic salpingitis 10.6 TNF TNFRSF1A TNFRSF1B
33 helicobacter pylori infection 10.6 HLA-DRB1 IL1B TNF
34 guillain-barre syndrome 10.5 TNF TNFRSF1A TNFRSF1B
35 autoimmune pancreatitis 10.5 HLA-DRB1 TNF
36 nontuberculous mycobacterial lung disease 10.5 HLA-A HLA-DRB1 TNF
37 alveolar echinococcosis 10.5 HLA-A HLA-DRB1 TNF
38 vogt-koyanagi-harada disease 10.5 HLA-A HLA-DRB1 PTPN22
39 rheumatic heart disease 10.5 HLA-A HLA-DRB1 TNF
40 dengue hemorrhagic fever 10.5 HLA-A HLA-DRB1 TNF
41 pharyngitis 10.4 CRP IL1B MEFV
42 rubella 10.4 HLA-A HLA-DRB1 TNF
43 leishmaniasis 10.4 HLA-DRB1 IL1B TNF
44 chronic beryllium disease 10.4 HLA-DRB1 TNF
45 dengue shock syndrome 10.4 HLA-A IL1B TNF
46 vulvar vestibulitis syndrome 10.4 IL1B TNF
47 scleral disease 10.4 MRAP TNF TNFRSF1B
48 pustulosis of palm and sole 10.4 MRAP TNF TNFRSF1B
49 hemorrhagic fever with renal syndrome 10.4 CRP HLA-DRB1 TNF
50 periodic fever, familial, autosomal dominant 10.4 MEFV TNF TNFRSF1A TNFRSF1B

Graphical network of the top 20 diseases related to Palindromic Rheumatism:



Diseases related to Palindromic Rheumatism

Symptoms & Phenotypes for Palindromic Rheumatism

UMLS symptoms related to Palindromic Rheumatism:


arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

MGI Mouse Phenotypes related to Palindromic Rheumatism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 PTPN22 TNF TNFRSF10A TNFRSF1A TNFRSF1B IL1B
2 immune system MP:0005387 9.77 TNF TNFRSF10A TNFRSF1A TNFRSF1B AGBL2 CRP
3 neoplasm MP:0002006 9.1 TNF TNFRSF10A TNFRSF1A TNFRSF1B ERBB3 IL1B

Drugs & Therapeutics for Palindromic Rheumatism

Search Clinical Trials , NIH Clinical Center for Palindromic Rheumatism

Cochrane evidence based reviews: palindromic rheumatism

Genetic Tests for Palindromic Rheumatism

Anatomical Context for Palindromic Rheumatism

MalaCards organs/tissues related to Palindromic Rheumatism:

41
Testes, Neutrophil, Lung, Heart

Publications for Palindromic Rheumatism

Articles related to Palindromic Rheumatism:

(show top 50) (show all 121)
# Title Authors Year
1
Is palindromic rheumatism amongst children a benign disease? ( 29439723 )
2018
2
Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis. ( 28619044 )
2017
3
Association between periodontitis and the risk of palindromic rheumatism: A nationwide, population-based, case-control study. ( 28771535 )
2017
4
What can palindromic rheumatism tell us? ( 29221602 )
2017
5
Palindromic Rheumatism-Like Migratory Non-Erosive Seronegative Polyarthritis in a Patient With Metastatic Conjunctival Malignant Melanoma. ( 29900944 )
2016
6
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis. ( 26235245 )
2015
7
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2015
8
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1A year of follow-up. ( 24623460 )
2014
9
Is there subclinical synovitis in patients with palindromic rheumatism in the intercritical period? A clinical and ultrasonographic study according to anticitrullinated protein antibody status. ( 25028368 )
2014
10
Anti-citrullinated peptide/protein antibodies in Palindromic rheumatism: comment on the article by Emad Y et al. ( 24797773 )
2014
11
Palindromic rheumatism: consider Whipple's disease. ( 23992271 )
2013
12
A multicenter study of clinical and laboratory findings of palindromic rheumatism in Iran. ( 22898224 )
2012
13
Palindromic rheumatism: a pre-rheumatoid arthritis state? ( 23028026 )
2012
14
Palindromic rheumatism with positive anticitrullinated peptide/protein antibodies is not synonymous with rheumatoid arthritis. A longterm followup study. ( 22859345 )
2012
15
Palindromic rheumatism: strategies to prevent evolution to rheumatoid arthritis. ( 22665157 )
2012
16
Myocardial infarction in a young female with palindromic rheumatism: a consequence of negative remodeling. ( 22536266 )
2012
17
Palindromic rheumatism. ( 21206416 )
2011
18
Palindromic rheumatism: a descriptive report of seven cases from North Dakota and a short review of literature. ( 19771490 )
2010
19
Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. ( 20476860 )
2010
20
Familial Mediterranean fever presenting as anti-cyclic citrullinated peptide antibody negative palindromic rheumatism. ( 20808171 )
2010
21
Association of ultrasonographic findings of synovitis with anti-cyclic citrullinated Peptide antibodies and rheumatoid factor in patients with palindromic rheumatism during active episodes. ( 19710217 )
2009
22
Palindromic rheumatism: longterm outcomes of 60 patients diagnosed in 1967-84. ( 19648311 )
2009
23
Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients. ( 18412310 )
2008
24
MEFV mutations and palindromic rheumatism: comment on the article by CaA+ete et al. ( 18512803 )
2008
25
Magnetic resonance imaging of palindromic rheumatism. ( 18663450 )
2008
26
TNF receptor I polymorphism is associated with persistent palindromic rheumatism. ( 17763205 )
2007
27
I've been diagnosed with palindromic rheumatism. It seems to come and go a lot. What is it and how can I treat it? ( 18290263 )
2007
28
An unexpectedly high frequency of MEFV mutations in patients with anti-citrullinated protein antibody-negative palindromic rheumatism. ( 17665427 )
2007
29
Palindromic rheumatism associated with primary hypertrophic osteoarthropathy. ( 17187097 )
2006
30
Short term palindromic rheumatism after clopidogrel use. ( 16611878 )
2006
31
The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis. ( 16724377 )
2006
32
Palindromic rheumatism: different genetic background implies a distinct disease entity. ( 17038462 )
2006
33
Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism. ( 16847371 )
2006
34
Antiphospholipid syndrome and palindromic rheumatism: a new possible association. ( 16189657 )
2005
35
Rheumatoid neutrophilic dermatitis: rare cutaneous manifestation of rheumatoid arthritis in a patient with palindromic rheumatism. ( 15290752 )
2004
36
Palindromic rheumatism and other relapsing arthritis. ( 15454124 )
2004
37
Prevalence and clinical significance of anti-cyclic citrullinated peptide and antikeratin antibodies in palindromic rheumatism. An abortive form of rheumatoid arthritis? ( 12730510 )
2003
38
HLA and cytokine gene polymorphisms in relation to occurrence of palindromic rheumatism and its progression to rheumatoid arthritis. ( 12415587 )
2002
39
Palindromic rheumatism. ( 12408287 )
2002
40
Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism. ( 24387063 )
2002
41
A patient with severe palindromic rheumatism and frequent episodes of pain. ( 11300148 )
2001
42
Palindromic rheumatism: effect of dietary manipulation. ( 10895376 )
2000
43
Decreased progression to rheumatoid arthritis or other connective tissue diseases in patients with palindromic rheumatism treated with antimalarials. ( 10648016 )
2000
44
Prognostic factors for the development of rheumatoid arthritis and other connective tissue diseases in patients with palindromic rheumatism. ( 10090159 )
1999
45
Clinical analysis of BehAset disease: arthritic manifestations in BehAset disease may present as seronegative rheumatoid arthritis or palindromic rheumatism. ( 10063316 )
1999
46
Sparing effect of hemiparesis on palindromic rheumatism. ( 9093804 )
1997
47
Remission in palindromic rheumatism during pregnancy. ( 8478889 )
1993
48
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. ( 1629832 )
1992
49
Rheumatoid nodules of the lung in a patient with palindromic rheumatism. ( 1450509 )
1992
50
[Myasthenia gravis, palindromic rheumatism and systemic lupus erythematosus. A clinical case report]. ( 1561476 )
1992

Variations for Palindromic Rheumatism

Expression for Palindromic Rheumatism

Search GEO for disease gene expression data for Palindromic Rheumatism.

Pathways for Palindromic Rheumatism

Pathways related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CRP DYNLT1 ERBB3 HLA-A HLA-DRB1 IL1B
2
Show member pathways
13.42 ERBB3 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
3
Show member pathways
13.32 ERBB3 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
4
Show member pathways
13.2 IL1B PTPN22 TNF TNFRSF10A TNFRSF10B TNFRSF1A
5
Show member pathways
13.17 ERBB3 HLA-A HLA-DRB1 IL1B PRTN3 TNF
6
Show member pathways
12.79 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7
Show member pathways
12.73 HLA-A HLA-DRB1 IL1B TNF TNFRSF1A TNFRSF1B
8
Show member pathways
12.72 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
9
Show member pathways
12.44 HLA-A TNF TNFRSF10A TNFRSF10B
10
Show member pathways
12.42 ERBB3 TNF TNFRSF1A TNFRSF1B
11
Show member pathways
12.37 IL1B TNF TNFRSF1A TNFRSF1B
12 12.34 HLA-A HLA-DRB1 TNF TNFRSF1A
13
Show member pathways
12.16 HLA-DRB1 IL1B TNF TNFRSF1A
14 12.15 IL1B PTPN22 TNF TNFRSF10B TNFRSF1A TNFRSF1B
15
Show member pathways
12.13 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
16 12.11 HLA-DRB1 IL1B TNF TNFRSF1A
17 12.03 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
18
Show member pathways
11.93 IL1B TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
19
Show member pathways
11.91 TNF TNFRSF1A TNFRSF1B
20 11.9 IL1B TNF TNFRSF1B
21
Show member pathways
11.89 HLA-A HLA-DRB1 IL1B
22
Show member pathways
11.89 IL1B TNF TNFRSF10A TNFRSF10B TNFRSF1A
23
Show member pathways
11.86 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
24 11.81 HLA-DRB1 IL1B TNF
25 11.8 IL1B TNF TNFRSF1A
26 11.77 HLA-DRB1 IL1B TNF
27 11.77 IL1B TNF TNFRSF1A TNFRSF1B
28
Show member pathways
11.66 TNF TNFRSF1A TNFRSF1B
29 11.62 TNF TNFRSF1A TNFRSF1B
30
Show member pathways
11.57 IL1B TNF TNFRSF1A
32 11.48 TNF TNFRSF1A TNFRSF1B
33
Show member pathways
11.42 TNF TNFRSF1A TNFRSF1B
34 11.18 TNF TNFRSF1A TNFRSF1B
35 11.13 HLA-DRB1 IL1B TNF
36 10.95 IL1B TNF TNFRSF1A TNFRSF1B
37 10.87 IL1B TNF

GO Terms for Palindromic Rheumatism

Cellular components related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.7 ERBB3 HLA-A TNF TNFRSF10A TNFRSF10B TNFRSF1A
2 membrane raft GO:0045121 9.26 PRTN3 TNF TNFRSF1A TNFRSF1B
3 cell surface GO:0009986 9.1 HLA-A HLA-DRB1 TNF TNFRSF10A TNFRSF10B TNFRSF1A

Biological processes related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 CRP ERBB3 IL1B PTPN22 TNF
2 cell surface receptor signaling pathway GO:0007166 9.95 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
3 cytokine-mediated signaling pathway GO:0019221 9.93 IL1B PRTN3 TNF TNFRSF1A TNFRSF1B
4 leukocyte migration GO:0050900 9.9 IL1B TNF TNFRSF10A TNFRSF10B
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 IL1B TNF TNFRSF10B TNFRSF1A
6 positive regulation of MAPK cascade GO:0043410 9.85 ERBB3 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
7 regulation of cell proliferation GO:0042127 9.85 ERBB3 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
8 negative regulation of inflammatory response GO:0050728 9.84 MEFV TNFRSF1A TNFRSF1B
9 tumor necrosis factor-mediated signaling pathway GO:0033209 9.83 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.81 TNF TNFRSF10A TNFRSF10B
11 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.8 TNFRSF10A TNFRSF10B TNFRSF1B
12 cellular response to mechanical stimulus GO:0071260 9.8 IL1B TNFRSF10A TNFRSF10B TNFRSF1A
13 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 TNF TNFRSF1A TNFRSF1B
14 extrinsic apoptotic signaling pathway GO:0097191 9.73 TNF TNFRSF10A TNFRSF1B
15 response to lipopolysaccharide GO:0032496 9.73 IL1B PTPN22 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 IL1B PTPN22 TNF
17 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.67 TNFRSF10A TNFRSF10B
18 negative regulation of lipid catabolic process GO:0050995 9.67 IL1B TNF
19 inflammatory response to antigenic stimulus GO:0002437 9.66 HLA-DRB1 IL1B
20 positive regulation of calcineurin-NFAT signaling cascade GO:0070886 9.65 ERBB3 TNF
21 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.65 TNFRSF10A TNFRSF10B
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF TNFRSF1B
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL1B TNF
24 negative regulation of lipid storage GO:0010888 9.62 CRP TNF
25 positive regulation of ceramide biosynthetic process GO:2000304 9.62 TNF TNFRSF1A
26 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.62 TNF TNFRSF10A TNFRSF10B TNFRSF1A
27 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
28 death-inducing signaling complex assembly GO:0071550 9.61 TNF TNFRSF1A
29 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
30 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF TNFRSF1A
31 immune response GO:0006955 9.56 HLA-A HLA-DRB1 IL1B TNF TNFRSF10A TNFRSF10B
32 sequestering of triglyceride GO:0030730 9.55 IL1B TNF
33 apoptotic signaling pathway GO:0097190 9.55 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 IL1B TNF
35 inflammatory response GO:0006954 9.23 CRP IL1B MEFV TNF TNFRSF10A TNFRSF10B
36 immune system process GO:0002376 10.04 HLA-A HLA-DRB1 LAIR1 MEFV PTPN22

Molecular functions related to Palindromic Rheumatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 CRP DYNLT1 ERBB3 HLA-A HLA-DRB1 IL1B
2 identical protein binding GO:0042802 9.8 CRP DYNLT1 ERBB3 MEFV MRAP TNF
3 TRAIL binding GO:0045569 9.16 TNFRSF10A TNFRSF10B
4 tumor necrosis factor-activated receptor activity GO:0005031 8.92 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF1B

Sources for Palindromic Rheumatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....