MCID: PLL016
MIFTS: 27

Palladium Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Palladium Allergic Contact Dermatitis

MalaCards integrated aliases for Palladium Allergic Contact Dermatitis:

Name: Palladium Allergic Contact Dermatitis 12 15
Allergic Contact Dermatitis to Pd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040055

Summaries for Palladium Allergic Contact Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that has allergic trigger palladium.

MalaCards based summary : Palladium Allergic Contact Dermatitis, also known as allergic contact dermatitis to pd, is related to allergic encephalomyelitis and chronic eosinophilic pneumonia. An important gene associated with Palladium Allergic Contact Dermatitis is CCL17 (C-C Motif Chemokine Ligand 17), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Related phenotypes are craniofacial and immune system

Related Diseases for Palladium Allergic Contact Dermatitis

Diseases related to Palladium Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 504)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 10.2 CCL3 CCL2
2 chronic eosinophilic pneumonia 10.2 CCL3 CCL2
3 near-fatal asthma 10.1 TNF CCL2
4 alveolar echinococcosis 10.1 TNF CCL17
5 granulocytopenia 10.1 TNF CSF2
6 periapical granuloma 10.1 CCL3 CCL2
7 mansonelliasis 10.1 IL10 CCL17
8 latex allergy 10.1 TNF CCL3
9 loiasis 10.1 IL10 CCL3
10 meningovascular neurosyphilis 10.1 TNF IL17A
11 mesangial proliferative glomerulonephritis 10.1 CCL3 CCL2
12 meconium aspiration syndrome 10.1 TNF CSF2
13 retinal vasculitis 10.1 TNF CCL2
14 enterocolitis 10.1 TNF IL10
15 farmer's lung 10.1 TNF IL17A
16 pustulosis of palm and sole 10.1 TNF IL17A
17 pneumonic plague 10.1 TNF IL17A
18 scleritis 10.1 TNF CCL2
19 juvenile arthritis 10.1 IL10 CSF2
20 pulmonary eosinophilia 10.1 CSF2 CCL3 CCL17
21 vitreous disease 10.1 TNF CCL2
22 punctate inner choroidopathy 10.1 TNF IL10
23 psoriasis 14, pustular 10.1 TNF IL17A
24 tropical endomyocardial fibrosis 10.1 TNF IL10
25 endomyocardial fibrosis 10.1 TNF IL10
26 pityriasis rubra pilaris 10.1 TNF IL17A
27 nasopharyngitis 10.1 TNF IL17A
28 acute kidney tubular necrosis 10.1 TNF CCL2
29 multifocal choroiditis 10.1 TNF IL10
30 autoimmune disease of urogenital tract 10.1 TNF IL17A
31 chromium allergic contact dermatitis 10.1 IL17A IL10
32 spotted fever 10.1 TNF IL10
33 spotted fever rickettsiosis 10.1 TNF IL10
34 neurosyphilis 10.0 IL17A IL10
35 metal allergy 10.0 IL17A IL10
36 tertiary syphilis 10.0 TNF IL10
37 cerebral sinovenous thrombosis 10.0 IL17A IL10
38 post-transplant lymphoproliferative disease 10.0 TNF IL10
39 trichinosis 10.0 IL17A IL10
40 transient hypogammaglobulinemia 10.0 TNF IL10
41 subcutaneous mycosis 10.0 IL17A IL10
42 progressive myoclonus epilepsy 8 10.0 TNF IL10
43 mycetoma 10.0 IL17A IL10
44 timothy grass allergy 10.0 IL17A IL10
45 nickel allergic contact dermatitis 10.0 IL17A IL10
46 erythema multiforme 10.0 TNF CCL17
47 dacryoadenitis 10.0 IL17A IL10
48 mucocutaneous leishmaniasis 10.0 TNF IL10
49 inflammatory bowel disease 18 10.0 IL17A IL10
50 clonorchiasis 10.0 TNF IL10

Graphical network of the top 20 diseases related to Palladium Allergic Contact Dermatitis:



Diseases related to Palladium Allergic Contact Dermatitis

Symptoms & Phenotypes for Palladium Allergic Contact Dermatitis

MGI Mouse Phenotypes related to Palladium Allergic Contact Dermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.35 CSF2 IL10 IL17A IL1B TNF
2 immune system MP:0005387 9.17 CCL17 CCL2 CSF2 IL10 IL17A IL1B

Drugs & Therapeutics for Palladium Allergic Contact Dermatitis

Search Clinical Trials , NIH Clinical Center for Palladium Allergic Contact Dermatitis

Genetic Tests for Palladium Allergic Contact Dermatitis

Anatomical Context for Palladium Allergic Contact Dermatitis

Publications for Palladium Allergic Contact Dermatitis

Articles related to Palladium Allergic Contact Dermatitis:

# Title Authors PMID Year
1
Immunotoxicity of nanoparticles. 61
21329568 2011
2
Effects of palladium nanoparticles on the cytokine release from peripheral blood mononuclear cells of non-atopic women. 61
20487634 2010

Variations for Palladium Allergic Contact Dermatitis

Expression for Palladium Allergic Contact Dermatitis

Search GEO for disease gene expression data for Palladium Allergic Contact Dermatitis.

Pathways for Palladium Allergic Contact Dermatitis

Pathways related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 TNF IL1B IL17A IL10 CSF2 CCL3
2
Show member pathways
13.64 TNF IL1B IL17A IL10 CSF2 CCL3
3
Show member pathways
13.49 TNF IL1B IL17A IL10 CSF2 CCL3
4
Show member pathways
13.4 TNF IL1B IL17A IL10 CCL3 CCL2
5
Show member pathways
13.24 TNF IL1B IL17A IL10 CSF2 CCL3
6
Show member pathways
13.21 TNF IL1B IL17A IL10 CSF2 CCL3
7
Show member pathways
13.1 TNF IL1B IL17A IL10 CSF2 CCL3
8
Show member pathways
13.07 TNF IL1B IL10 CCL3 CCL2
9
Show member pathways
12.85 TNF IL1B CSF2 CCL3 CCL2
10
Show member pathways
12.73 TNF IL1B IL17A IL10
11
Show member pathways
12.55 TNF IL1B IL17A IL10 CSF2
12
Show member pathways
12.54 TNF IL1B IL17A IL10 CCL2
13
Show member pathways
12.51 TNF IL1B IL17A IL10
14 12.51 TNF IL1B IL17A IL10 CCL2
15 12.28 TNF IL1B CSF2
16
Show member pathways
12.27 TNF IL10 CCL3 CCL2 CCL17
17
Show member pathways
12.22 TNF IL1B CCL2
18
Show member pathways
12.18 TNF IL1B IL17A IL10
19
Show member pathways
12.18 TNF IL1B IL10 CCL17
20
Show member pathways
12.16 TNF IL1B IL10
21 12.13 TNF IL1B CCL2
22 12.13 TNF IL1B IL10
23
Show member pathways
12.13 TNF IL1B IL17A CSF2 CCL2 CCL17
24 12.08 TNF IL1B IL10
25 12.07 TNF IL1B IL10 CCL2
26 12.01 TNF IL1B CCL2
27 11.97 TNF IL1B CSF2 CCL2
28 11.94 TNF IL1B CCL2
29 11.93 TNF IL1B IL17A IL10 CCL2
30 11.92 TNF IL10 CSF2
31 11.9 TNF IL1B IL10 CSF2
32 11.85 TNF IL1B CCL2
33 11.84 TNF IL1B CSF2
34
Show member pathways
11.76 TNF IL1B IL17A IL10
35 11.73 TNF IL1B IL10 CSF2
36 11.72 TNF IL1B IL10
37 11.71 TNF IL1B IL17A IL10 CCL3
38
Show member pathways
11.63 TNF IL1B CSF2
39 11.6 TNF IL1B IL17A CSF2 CCL3 CCL2
40 11.52 TNF IL1B IL10 CCL2
41 11.51 TNF IL1B CCL2
42 11.45 TNF IL1B CSF2 CCL3 CCL2
43 11.39 TNF IL1B IL10
44
Show member pathways
11.37 TNF IL10 CSF2 CCL3
45 11.36 TNF IL1B IL10
46 11.31 TNF IL1B IL17A
47 11.26 TNF IL1B IL10 CSF2
48 11.2 TNF IL1B
49 11.11 IL1B CCL2
50 11.05 TNF IL1B

GO Terms for Palladium Allergic Contact Dermatitis

Cellular components related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TNF IL1B IL17A IL10 CSF2 CCL3
2 extracellular space GO:0005615 9.23 TNF IL1B IL17A IL10 CSF2 CCL3

Biological processes related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TNF IL1B CSF2 CCL3
2 cell-cell signaling GO:0007267 9.86 IL1B IL17A CCL3 CCL17
3 chemotaxis GO:0006935 9.85 CCL3 CCL2 CCL17
4 MAPK cascade GO:0000165 9.85 TNF IL1B CSF2 CCL3 CCL2
5 cellular response to tumor necrosis factor GO:0071356 9.84 CCL3 CCL2 CCL17
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.84 TNF CCL3 CCL2 CCL17
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNF IL1B IL10
8 cellular response to interferon-gamma GO:0071346 9.82 CCL3 CCL2 CCL17
9 positive regulation of inflammatory response GO:0050729 9.81 TNF IL1B CCL3
10 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL1B IL17A
11 neutrophil chemotaxis GO:0030593 9.79 CCL3 CCL2 CCL17
12 chemokine-mediated signaling pathway GO:0070098 9.78 CCL3 CCL2 CCL17
13 cellular response to lipopolysaccharide GO:0071222 9.77 TNF IL1B IL10 CSF2 CCL2
14 positive regulation of interleukin-1 beta production GO:0032731 9.74 TNF IL17A CCL3
15 cellular response to interleukin-1 GO:0071347 9.73 IL17A CCL3 CCL2 CCL17
16 inflammatory response GO:0006954 9.73 TNF IL1B IL17A CCL3 CCL2 CCL17
17 regulation of sensory perception of pain GO:0051930 9.71 IL10 CCL3
18 positive regulation of JAK-STAT cascade GO:0046427 9.71 TNF IL10
19 cellular response to organic cyclic compound GO:0071407 9.71 TNF IL1B CCL3 CCL2
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 TNF IL1B
21 regulation of synapse organization GO:0050807 9.7 TNF IL10
22 negative regulation of neurogenesis GO:0050768 9.7 TNF IL1B
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.7 TNF IL17A
24 monocyte chemotaxis GO:0002548 9.7 CCL3 CCL2 CCL17
25 negative regulation of myoblast differentiation GO:0045662 9.69 TNF CCL17
26 positive regulation of osteoclast differentiation GO:0045672 9.69 TNF IL17A
27 positive regulation of glial cell proliferation GO:0060252 9.69 TNF IL1B
28 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.69 TNF IL1B CSF2
29 negative regulation of lipid catabolic process GO:0050995 9.68 TNF IL1B
30 eosinophil chemotaxis GO:0048245 9.68 CCL3 CCL2
31 positive regulation of calcium ion import GO:0090280 9.68 CCL3 CCL2
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IL1B
33 lymphocyte chemotaxis GO:0048247 9.67 CCL3 CCL2 CCL17
34 macrophage chemotaxis GO:0048246 9.66 CCL3 CCL2
35 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL1B
36 positive regulation of podosome assembly GO:0071803 9.65 TNF CSF2
37 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 TNF IL1B IL10
39 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
40 vascular endothelial growth factor production GO:0010573 9.62 TNF IL1B
41 protein kinase B signaling GO:0043491 9.62 TNF IL1B CCL3 CCL2
42 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
43 astrocyte cell migration GO:0043615 9.6 CCL3 CCL2
44 positive regulation of interleukin-23 production GO:0032747 9.59 IL17A CSF2
45 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
46 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 TNF IL1B
48 cytokine-mediated signaling pathway GO:0019221 9.5 TNF IL1B IL17A IL10 CSF2 CCL3
49 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 TNF IL1B CCL3 CCL2
50 immune response GO:0006955 9.23 TNF IL1B IL17A IL10 CSF2 CCL3

Molecular functions related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL3 CCL2 CCL17
2 cytokine activity GO:0005125 9.23 TNF IL1B IL17A IL10 CSF2 CCL3
3 CCR chemokine receptor binding GO:0048020 9.13 CCL3 CCL2 CCL17

Sources for Palladium Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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