MCID: PLL016
MIFTS: 28

Palladium Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Palladium Allergic Contact Dermatitis

MalaCards integrated aliases for Palladium Allergic Contact Dermatitis:

Name: Palladium Allergic Contact Dermatitis 12 15
Allergic Contact Dermatitis to Pd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040055

Summaries for Palladium Allergic Contact Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that has_allergic_trigger palladium.

MalaCards based summary : Palladium Allergic Contact Dermatitis, also known as allergic contact dermatitis to pd, is related to trichosporonosis and eosinophilic pneumonia. An important gene associated with Palladium Allergic Contact Dermatitis is CCL17 (C-C Motif Chemokine Ligand 17), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include skin, lung and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Palladium Allergic Contact Dermatitis

Diseases related to Palladium Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 trichosporonosis 10.1 CSF2 IL17A
2 eosinophilic pneumonia 10.1 CCL17 CSF2
3 ileitis 10.1 CSF2 IL17A
4 coronary artery aneurysm 10.1 CCL17 CCL2
5 radiculopathy 10.1 CCL2 IL17A
6 langerhans cell histiocytosis 10.1 CSF2 IL17A
7 histiocytosis 10.1 CSF2 IL17A
8 mastitis 10.0 CSF2 IL17A
9 stachybotrys chartarum 10.0 CCL2 CCL3
10 tuberculous meningitis 10.0 CCL2 CCL3
11 contact dermatitis 10.0 CCL17 IL10
12 cytomegalovirus infection 10.0 CCL2 CCL3
13 pulmonary alveolar proteinosis 10.0 CCL2 CSF2
14 apple allergy 10.0 CCL17 IL10
15 churg-strauss syndrome 10.0 CCL17 IL10
16 neurosyphilis 10.0 IL10 IL17A
17 cystic echinococcosis 10.0 IL10 IL17A
18 autoimmune disease of eyes, ear, nose and throat 10.0 IL10 IL17A
19 transverse myelitis 10.0 IL10 IL17A
20 primary systemic mycosis 10.0 IL10 IL17A
21 mycoplasma pneumoniae pneumonia 10.0 IL10 IL17A
22 autoimmune optic neuritis 10.0 IL10 IL17A
23 panuveitis 10.0 IL10 IL17A
24 polyradiculoneuropathy 10.0 IL10 IL17A
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0 IL10 IL17A
26 paranasal sinus disease 10.0 IL10 IL17A
27 pulmonary sarcoidosis 10.0 CCL2 CSF2
28 opportunistic mycosis 10.0 IL10 IL17A
29 orofacial granulomatosis 10.0 CCL3 IL10
30 uveal disease 10.0 IL10 IL17A
31 reactive arthritis 10.0 IL10 IL17A
32 respiratory allergy 10.0 IL10 IL17A
33 tropical spastic paraparesis 10.0 IL10 IL17A
34 pulmonary tuberculosis 9.9 CCL3 IL10
35 bronchiolitis obliterans 9.9 IL10 IL17A
36 spondyloarthropathy 9.9 IL10 IL17A
37 vogt-koyanagi-harada disease 9.9 IL10 IL17A
38 fungal meningitis 9.9 CCL2 IL10
39 human immunodeficiency virus infectious disease 9.9 CCL3 IL10
40 autoimmune disease of musculoskeletal system 9.9 IL10 IL17A
41 lipoid nephrosis 9.9 CCL2 IL10
42 upper respiratory tract disease 9.9 IL10 IL17A
43 extrapulmonary tuberculosis 9.9 CCL2 IL10
44 primary bacterial infectious disease 9.9 IL10 IL17A
45 complex regional pain syndrome 9.9 CCL2 IL10
46 viral encephalitis 9.9 CCL2 IL10
47 chronic mucocutaneous candidiasis 9.9 IL10 IL17A
48 candidiasis 9.9 IL10 IL17A
49 pyelonephritis 9.9 CCL2 IL10
50 leptospirosis 9.9 CCL2 IL10

Graphical network of the top 20 diseases related to Palladium Allergic Contact Dermatitis:



Diseases related to Palladium Allergic Contact Dermatitis

Symptoms & Phenotypes for Palladium Allergic Contact Dermatitis

GenomeRNAi Phenotypes related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.64 IL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.64 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.64 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.64 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.64 CSF2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.64 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.64 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.64 CSF2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.64 CSF2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.64 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.64 CSF2 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.64 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.64 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.64 CSF2 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.64 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.64 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 IL10

Drugs & Therapeutics for Palladium Allergic Contact Dermatitis

Search Clinical Trials , NIH Clinical Center for Palladium Allergic Contact Dermatitis

Genetic Tests for Palladium Allergic Contact Dermatitis

Anatomical Context for Palladium Allergic Contact Dermatitis

MalaCards organs/tissues related to Palladium Allergic Contact Dermatitis:

41
Skin, Lung, Bone, Eye, T Cells

Publications for Palladium Allergic Contact Dermatitis

Variations for Palladium Allergic Contact Dermatitis

Expression for Palladium Allergic Contact Dermatitis

Search GEO for disease gene expression data for Palladium Allergic Contact Dermatitis.

Pathways for Palladium Allergic Contact Dermatitis

Pathways related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
2
Show member pathways
13.31 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
3
Show member pathways
13.21 CCL17 CCL2 CCL3 IL10 IL17A
4
Show member pathways
13.06 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
5
Show member pathways
13.04 CCL2 CCL3 CSF2 IL10 IL17A
6
Show member pathways
12.95 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
7
Show member pathways
12.58 CCL17 CCL2 CCL3
8
Show member pathways
12.31 CCL2 IL10 IL17A
9 12.29 CCL2 IL10 IL17A
10
Show member pathways
12.18 CSF2 IL10 IL17A
11
Show member pathways
12.09 CCL17 CCL2 CSF2 IL17A
12
Show member pathways
11.92 CCL17 CCL2 CCL3
13
Show member pathways
11.79 CCL17 CCL2 CCL3
14
Show member pathways
11.78 CCL17 CCL2 CCL3 IL10 IL17A
15 11.76 CCL2 IL10 IL17A
16 11.63 CSF2 IL10
17
Show member pathways
11.61 CSF2 IL17A
18 11.59 CCL3 IL10 IL17A
19 11.58 CCL2 CCL3 CSF2 IL17A
20 11.57 CCL3 CSF2
21 11.5 CSF2 IL10
22 11.45 CCL2 CCL3 CSF2
23 11.42 CCL17 IL10
24 11.31 CCL2 IL10
25 11.27 CCL17 IL10
26 11.25 CCL2 CCL3 CSF2 IL10
27 11.05 CSF2 IL10
28 10.95 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
29 10.77 CCL2 CCL3
30 10.66 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
31 10.54 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

GO Terms for Palladium Allergic Contact Dermatitis

Cellular components related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
2 extracellular space GO:0005615 9.1 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

Biological processes related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.8 CCL17 CCL2 CCL3
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 CCL17 CCL2 CCL3
3 cell-cell signaling GO:0007267 9.77 CCL17 CCL3 IL17A
4 MAPK cascade GO:0000165 9.76 CCL2 CCL3 CSF2
5 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CSF2 IL10
6 chemotaxis GO:0006935 9.72 CCL17 CCL2 CCL3
7 inflammatory response GO:0006954 9.72 CCL17 CCL2 CCL3 IL10 IL17A
8 cellular response to tumor necrosis factor GO:0071356 9.7 CCL17 CCL2 CCL3
9 cellular response to interferon-gamma GO:0071346 9.69 CCL17 CCL2 CCL3
10 neutrophil chemotaxis GO:0030593 9.65 CCL17 CCL2 CCL3
11 cell chemotaxis GO:0060326 9.63 CCL2 CCL3
12 cellular response to organic cyclic compound GO:0071407 9.63 CCL2 CCL3
13 protein kinase B signaling GO:0043491 9.62 CCL2 CCL3
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 CCL2 CCL3
15 regulation of sensory perception of pain GO:0051930 9.61 CCL3 IL10
16 chemokine-mediated signaling pathway GO:0070098 9.61 CCL17 CCL2 CCL3
17 eosinophil chemotaxis GO:0048245 9.58 CCL2 CCL3
18 monocyte chemotaxis GO:0002548 9.58 CCL17 CCL2 CCL3
19 positive regulation of calcium ion import GO:0090280 9.57 CCL2 CCL3
20 cellular response to interleukin-1 GO:0071347 9.56 CCL17 CCL2 CCL3 IL17A
21 cytokine-mediated signaling pathway GO:0019221 9.55 CCL2 CCL3 CSF2 IL10 IL17A
22 macrophage chemotaxis GO:0048246 9.54 CCL2 CCL3
23 lymphocyte chemotaxis GO:0048247 9.54 CCL17 CCL2 CCL3
24 astrocyte cell migration GO:0043615 9.49 CCL2 CCL3
25 positive regulation of interleukin-23 production GO:0032747 9.46 CSF2 IL17A
26 immune response GO:0006955 9.43 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
27 regulation of signaling receptor activity GO:0010469 9.1 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

Molecular functions related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL17 CCL2 CCL3
2 CCR chemokine receptor binding GO:0048020 9.13 CCL17 CCL2 CCL3
3 cytokine activity GO:0005125 9.1 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

Sources for Palladium Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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