MCID: PLL016
MIFTS: 25

Palladium Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Palladium Allergic Contact Dermatitis

MalaCards integrated aliases for Palladium Allergic Contact Dermatitis:

Name: Palladium Allergic Contact Dermatitis 12 15
Allergic Contact Dermatitis to Pd 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040055

Summaries for Palladium Allergic Contact Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that has_allergic_trigger palladium.

MalaCards based summary : Palladium Allergic Contact Dermatitis, also known as allergic contact dermatitis to pd, is related to eosinophilic pneumonia and trichosporonosis. An important gene associated with Palladium Allergic Contact Dermatitis is CCL17 (C-C Motif Chemokine Ligand 17), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Palladium Allergic Contact Dermatitis

Diseases related to Palladium Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 eosinophilic pneumonia 10.2 CCL17 CSF2
2 trichosporonosis 10.2 CSF2 IL17A
3 ileitis 10.1 CSF2 IL17A
4 coronary artery aneurysm 10.1 CCL17 CCL2
5 langerhans cell histiocytosis 10.1 CSF2 IL17A
6 histiocytosis 10.1 CSF2 IL17A
7 mastitis 10.1 CSF2 IL17A
8 stachybotrys chartarum 10.1 CCL2 CCL3
9 pulmonary alveolar proteinosis 10.0 CCL2 CSF2
10 tuberculous meningitis 10.0 CCL2 CCL3
11 contact dermatitis 10.0 CCL17 IL10
12 cytomegalovirus infection 10.0 CCL2 CCL3
13 apple allergy 10.0 CCL17 IL10
14 peanut allergy 10.0 CCL17 IL10
15 churg-strauss syndrome 10.0 CCL17 IL10
16 pulmonary sarcoidosis 10.0 CCL2 CSF2
17 neurosyphilis 9.9 IL10 IL17A
18 cystic echinococcosis 9.9 IL10 IL17A
19 autoimmune disease of eyes, ear, nose and throat 9.9 IL10 IL17A
20 orofacial granulomatosis 9.9 CCL3 IL10
21 transverse myelitis 9.9 IL10 IL17A
22 primary systemic mycosis 9.9 IL10 IL17A
23 mycoplasma pneumoniae pneumonia 9.9 IL10 IL17A
24 radiculopathy 9.9 IL10 IL17A
25 autoimmune optic neuritis 9.9 IL10 IL17A
26 sarcoidosis 1 9.9 CCL17 CCL3 CSF2
27 panuveitis 9.9 IL10 IL17A
28 polyradiculoneuropathy 9.9 IL10 IL17A
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 IL10 IL17A
30 pulmonary tuberculosis 9.9 CCL3 IL10
31 paranasal sinus disease 9.9 IL10 IL17A
32 spondyloarthropathy 9.9 IL10 IL17A
33 opportunistic mycosis 9.9 IL10 IL17A
34 uveal disease 9.9 IL10 IL17A
35 fungal meningitis 9.9 CCL2 IL10
36 reactive arthritis 9.9 IL10 IL17A
37 respiratory allergy 9.9 IL10 IL17A
38 tropical spastic paraparesis 9.9 IL10 IL17A
39 human immunodeficiency virus infectious disease 9.9 CCL3 IL10
40 bronchiolitis obliterans 9.9 IL10 IL17A
41 lipoid nephrosis 9.9 CCL2 IL10
42 extrapulmonary tuberculosis 9.9 CCL2 IL10
43 complex regional pain syndrome 9.8 CCL2 IL10
44 vogt-koyanagi-harada disease 9.8 IL10 IL17A
45 viral encephalitis 9.8 CCL2 IL10
46 autoimmune disease of musculoskeletal system 9.8 IL10 IL17A
47 pyelonephritis 9.8 CCL2 IL10
48 leptospirosis 9.8 CCL2 IL10
49 pulmonary fibrosis, idiopathic 9.8 CCL17 CCL2 CCL3
50 upper respiratory tract disease 9.8 IL10 IL17A

Graphical network of the top 20 diseases related to Palladium Allergic Contact Dermatitis:



Diseases related to Palladium Allergic Contact Dermatitis

Symptoms & Phenotypes for Palladium Allergic Contact Dermatitis

GenomeRNAi Phenotypes related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

27 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.66 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.66 IL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.66 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.66 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.66 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.66 CSF2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.66 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.66 CSF2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.66 CSF2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.66 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.66 CSF2 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 IL10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.66 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.66 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.66 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.66 CSF2 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.66 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.66 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 IL10

Drugs & Therapeutics for Palladium Allergic Contact Dermatitis

Search Clinical Trials , NIH Clinical Center for Palladium Allergic Contact Dermatitis

Genetic Tests for Palladium Allergic Contact Dermatitis

Anatomical Context for Palladium Allergic Contact Dermatitis

Publications for Palladium Allergic Contact Dermatitis

Variations for Palladium Allergic Contact Dermatitis

Expression for Palladium Allergic Contact Dermatitis

Search GEO for disease gene expression data for Palladium Allergic Contact Dermatitis.

Pathways for Palladium Allergic Contact Dermatitis

Pathways related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
2
Show member pathways
13.31 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
3
Show member pathways
13.21 CCL17 CCL2 CCL3 IL10 IL17A
4
Show member pathways
13.06 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
5
Show member pathways
13.04 CCL2 CCL3 CSF2 IL10 IL17A
6
Show member pathways
12.95 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
7
Show member pathways
12.58 CCL17 CCL2 CCL3
8
Show member pathways
12.31 CCL2 IL10 IL17A
9 12.29 CCL2 IL10 IL17A
10
Show member pathways
12.18 CSF2 IL10 IL17A
11
Show member pathways
12.09 CCL17 CCL2 CSF2 IL17A
12
Show member pathways
11.92 CCL17 CCL2 CCL3
13
Show member pathways
11.79 CCL17 CCL2 CCL3
14
Show member pathways
11.78 CCL17 CCL2 CCL3 IL10 IL17A
15 11.76 CCL2 IL10 IL17A
16 11.63 CSF2 IL10
17
Show member pathways
11.61 CSF2 IL17A
18 11.59 CCL3 IL10 IL17A
19 11.58 CCL2 CCL3 CSF2 IL17A
20 11.57 CCL3 CSF2
21 11.5 CSF2 IL10
22 11.45 CCL2 CCL3 CSF2
23 11.42 CCL17 IL10
24 11.31 CCL2 IL10
25 11.27 CCL17 IL10
26 11.25 CCL2 CCL3 CSF2 IL10
27 11.05 CSF2 IL10
28 10.95 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
29 10.77 CCL2 CCL3
30 10.66 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
31 10.54 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

GO Terms for Palladium Allergic Contact Dermatitis

Cellular components related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
2 extracellular space GO:0005615 9.1 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

Biological processes related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.8 CCL17 CCL2 CCL3
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 CCL17 CCL2 CCL3
3 cell-cell signaling GO:0007267 9.77 CCL17 CCL3 IL17A
4 MAPK cascade GO:0000165 9.76 CCL2 CCL3 CSF2
5 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CSF2 IL10
6 chemotaxis GO:0006935 9.72 CCL17 CCL2 CCL3
7 inflammatory response GO:0006954 9.72 CCL17 CCL2 CCL3 IL10 IL17A
8 cellular response to tumor necrosis factor GO:0071356 9.7 CCL17 CCL2 CCL3
9 cellular response to interferon-gamma GO:0071346 9.69 CCL17 CCL2 CCL3
10 neutrophil chemotaxis GO:0030593 9.65 CCL17 CCL2 CCL3
11 cell chemotaxis GO:0060326 9.63 CCL2 CCL3
12 cellular response to organic cyclic compound GO:0071407 9.63 CCL2 CCL3
13 protein kinase B signaling GO:0043491 9.62 CCL2 CCL3
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 CCL2 CCL3
15 regulation of sensory perception of pain GO:0051930 9.61 CCL3 IL10
16 chemokine-mediated signaling pathway GO:0070098 9.61 CCL17 CCL2 CCL3
17 eosinophil chemotaxis GO:0048245 9.58 CCL2 CCL3
18 monocyte chemotaxis GO:0002548 9.58 CCL17 CCL2 CCL3
19 positive regulation of calcium ion import GO:0090280 9.57 CCL2 CCL3
20 cellular response to interleukin-1 GO:0071347 9.56 CCL17 CCL2 CCL3 IL17A
21 cytokine-mediated signaling pathway GO:0019221 9.55 CCL2 CCL3 CSF2 IL10 IL17A
22 macrophage chemotaxis GO:0048246 9.54 CCL2 CCL3
23 lymphocyte chemotaxis GO:0048247 9.54 CCL17 CCL2 CCL3
24 astrocyte cell migration GO:0043615 9.49 CCL2 CCL3
25 positive regulation of interleukin-23 production GO:0032747 9.46 CSF2 IL17A
26 immune response GO:0006955 9.43 CCL17 CCL2 CCL3 CSF2 IL10 IL17A
27 regulation of signaling receptor activity GO:0010469 9.1 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

Molecular functions related to Palladium Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CCL17 CCL2 CCL3
2 CCR chemokine receptor binding GO:0048020 9.13 CCL17 CCL2 CCL3
3 cytokine activity GO:0005125 9.1 CCL17 CCL2 CCL3 CSF2 IL10 IL17A

Sources for Palladium Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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