MCID: PNC034
MIFTS: 57

Pancreas Disease

Categories: Gastrointestinal diseases, Endocrine diseases

Aliases & Classifications for Pancreas Disease

Summaries for Pancreas Disease

Disease Ontology : 12 An endocrine system disease that is located in the pancreas.

MalaCards based summary : Pancreas Disease, also known as abnormality of the pancreas, is related to endocrine pancreas disease and pancreatic agenesis 1, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Pancreas Disease is INS (Insulin), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Pancrelipase and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include the pancreas, pancreas and lung, and related phenotypes are homeostasis/metabolism and adipose tissue

Related Diseases for Pancreas Disease

Diseases related to Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 endocrine pancreas disease 31.0 ABCC8 DPP4 GCG IGF1 INS LEP
2 pancreatic agenesis 1 30.7 SCT SPINK1
3 pancreatitis 30.4 CCK PRSS1 SCT SPINK1 SST
4 duodenal ulcer 30.3 CCK INS SCT SST
5 acute pancreatitis 30.3 CCK SCT SPINK1 SST
6 diabetes mellitus, noninsulin-dependent 28.8 ABCC8 DPP4 GCG IGF1 INS LEP
7 bronchus adenoma 11.1 POMC SST
8 scleredema adultorum 11.0 INS POMC
9 postgastrectomy syndrome 11.0 INS SST
10 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 11.0 IGF1 INS
11 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 11.0 LEP POMC
12 type 1 diabetes mellitus 15 11.0 GCG INS
13 postural hypotension 11.0 INS SST
14 pancreatic gastrinoma 11.0 SCT SST
15 functional gastric disease 10.9 CCK SST TRPV1
16 maturity-onset diabetes of the young, type 3 10.9 CELA3B INS
17 central nervous system germinoma 10.9 AVP POMC
18 dyspepsia 10.9 CCK SST TRPV1
19 pain agnosia 10.9 CCK POMC TRPV1
20 recurrent acute pancreatitis 10.9 PRSS1 SCT SPINK1
21 pituitary-dependent cushing's disease 10.9 INS POMC SST
22 agnosia 10.9 CCK POMC TRPV1
23 female reproductive system disease 10.9 INS POMC TRPV1
24 stomach disease 10.9 CCK SST TRPV1
25 sheehan syndrome 10.9 IGF1 INS POMC
26 gastrinoma 10.9 INS SCT SST
27 tuberculous epididymitis 10.9 AVP POMC
28 chiasmal syndrome 10.9 POMC SST
29 acidophil adenoma 10.9 IGF1 POMC SST
30 gallbladder disease 10.9 CCK INS SST
31 hyperinsulinemic hypoglycemia 10.9 ABCC8 INS SST
32 sick building syndrome 10.9 LEP POMC TRPV1
33 biliary dyskinesia 10.9 CCK SCT
34 pituitary infarct 10.9 IGF1 POMC SST
35 duodenogastric reflux 10.9 CCK SCT SST
36 lipodystrophy, familial partial, type 2 10.9 INS LEP
37 thyroid gland disease 10.9 IGF1 INS POMC
38 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.9 INS LEP
39 gonadal disease 10.9 IGF1 INS POMC
40 central nervous system germ cell tumor 10.9 AVP POMC
41 secondary adrenal insufficiency 10.9 AVP IGF1 INS
42 fetal macrosomia 10.8 IGF1 INS LEP
43 specific developmental disorder 10.8 CCK POMC TRPV1
44 endocrine organ benign neoplasm 10.8 IGF1 POMC SST
45 pancreatic somatostatinoma 10.8 PPY SST
46 chromophobe adenoma 10.8 AVP INS POMC
47 hyperandrogenism 10.8 IGF1 INS POMC
48 pituitary tumors 10.8 IGF1 POMC SST
49 duodenal somatostatinoma 10.8 INS PPY SST
50 acute insulin response 10.8 ABCC8 GCG INS

Graphical network of the top 20 diseases related to Pancreas Disease:



Diseases related to Pancreas Disease

Symptoms & Phenotypes for Pancreas Disease

UMLS symptoms related to Pancreas Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, digestive system symptom, gastrointestinal gas

MGI Mouse Phenotypes related to Pancreas Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 LEP POMC SLC5A2 SPINK1 ABCC8 SST
2 adipose tissue MP:0005375 9.73 INS LEP POMC SLC5A2 TRPV1 IGF1
3 no phenotypic analysis MP:0003012 9.61 POMC SLC5A2 SPINK1 ABCC8 SST AVP
4 renal/urinary system MP:0005367 9.23 LEP POMC SLC5A2 AVP TRPV1 CCK

Drugs & Therapeutics for Pancreas Disease

Drugs for Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 928)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 51-43-4 5816
3
Racepinephrine Approved Phase 4,Phase 2,Not Applicable 329-65-7 838
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
5
Acetaminophen Approved Phase 4,Phase 1,Not Applicable 103-90-2 1983
6
Clonidine Approved Phase 4 4205-90-7 2803
7 Nefopam Approved, Investigational Phase 4 13669-70-0
8
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 84057-95-4 71273 175805
9
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
10
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 27203-92-5 33741
11
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
12
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 55-56-1 9552079 2713
13
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 119478-56-7 64778 441130
14
Metronidazole Approved Phase 4,Phase 1 443-48-1 4173
15
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
16 lanreotide Approved Phase 4,Phase 3,Phase 2,Phase 1 108736-35-2
17
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83150-76-9 383414 6400441
18
Ceftazidime Approved Phase 4,Phase 1,Not Applicable 78439-06-2, 72558-82-8 5481173
19
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 32986-56-4 5496 36294
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 437-38-7 3345
21
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 2078-54-8 4943
22
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
23
Diclofenac Approved, Vet_approved Phase 4,Phase 1,Not Applicable 15307-86-5 3033
24
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2216-51-5 16666
25
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
26
Insulin Glargine Approved Phase 4,Phase 3 160337-95-1
27
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
28
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59467-70-8 4192
29
Dalteparin Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9005-49-6
30
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 9005-49-6 772 46507594
31
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
32
Ketorolac Approved Phase 4,Phase 2,Phase 3,Phase 1 74103-06-3, 66635-83-4 3826
33
Aztreonam Approved Phase 4,Phase 3,Phase 2,Not Applicable 78110-38-0 5362041 5742832
34
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 95058-81-4 60750
35
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 33069-62-4 36314
36
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
37
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
38
Sunitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 341031-54-7, 557795-19-4 5329102
39
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 169590-42-5 2662
40
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 23994
41
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
42
Oxycodone Approved, Illicit, Investigational Phase 4,Not Applicable 76-42-6 5284603
43
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
44
Remifentanil Approved Phase 4 132875-61-7 60815
45
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
46
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
47
Protein C Approved Phase 4,Phase 2,Phase 1
48
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 2 114-07-8 12560
49
Glycolic acid Approved, Investigational Phase 4 79-14-1 757
50
Thrombin Approved, Investigational Phase 4

Interventional clinical trials:

(show top 50) (show all 3478)
# Name Status NCT ID Phase Drugs
1 Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection Unknown status NCT00661648 Phase 4
2 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
3 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
4 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
5 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
6 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
7 Prospective Random Comparing Study on EUS-guided Pseudocyst Drainage by Naso-pancreatic Tube and Stents Unknown status NCT01585662 Phase 4
8 Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy Unknown status NCT01070758 Phase 4 Lanreotide autogel
9 Evaluation of EUS-Guided 22 Gauge Core Biopsy Versus Fine-needle Aspiration for Suspected Pancreatic Neoplasms Unknown status NCT01673334 Phase 4
10 Impact of Immunonutrition on the Patients With Cystic Fibrosis Unknown status NCT02048592 Phase 4
11 CPET in CF Patients With One G551D Mutation Taking VX770 Unknown status NCT01937325 Phase 4 ivacaftor;placebo
12 Duration of Antibiotics in Infective Exacerbations of Cystic Fibrosis Unknown status NCT01044719 Phase 4 Ceftazidime;Tobramycin;Meropenem
13 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Unknown status NCT02759718 Phase 4
14 Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy Unknown status NCT01969110 Phase 4
15 Parenteral Fish Oil in Major Laparoscopic Abdominal Surgery Unknown status NCT01819961 Phase 4 MCT/LCT and fish oil;MCT/LCT
16 RCT: Difference in Diagnostic Yield Between EUSFNA Needles With and Without a Side Port in Pancreatic Masses Completed NCT02092519 Phase 4
17 Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP) Completed NCT01350037 Phase 4 alfentanil;remifentanil
18 Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
19 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
20 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
21 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
22 Post ERCP Pancreatitis Prevention in Average Risk Patients Completed NCT01784445 Phase 4 Ceftazidime
23 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
24 Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant Completed NCT01186562 Phase 4 Sitagliptin;Placebo
25 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
26 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
27 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
28 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
29 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
30 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
31 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
32 Creon After Pancreatic Surgery Completed NCT00535756 Phase 4 Creon;Placebo
33 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
34 A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died Completed NCT00061438 Phase 4 meropenem
35 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
36 Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy Completed NCT01550406 Phase 4
37 Role of Octreotide in Preventing Pancreatic Fistula After Pancreaticoduodenectomy (PD) in Patients With Soft Pancreas Completed NCT01301222 Phase 4 Inj. Octreotide
38 Enteral Nutrition in the Treatment of Pancreatic Fistulas - A Prospective Study Completed NCT01025414 Phase 4 enteral nutrition;Parenteral nutrition
39 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
40 Electro Flo 5000 and Vest Therapy Completed NCT02277626 Phase 4
41 Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations Completed NCT03256799 Phase 4 Ivacaftor
42 A Study of the Effects of Lumacaftor/Ivacaftor on Exercise Tolerance in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation Completed NCT02875366 Phase 4 LUM/IVA;Placebo
43 EASY: Extended Access to Sollpura Over Years Completed NCT02823964 Phase 4 Liprotamase
44 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
45 Backpack Carrying in Children With Cystic Fibrosis Completed NCT02700282 Phase 4
46 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
47 Steady-state Pharmacokinetics of Ceftazidime/Avibactam in Cystic Fibrosis Completed NCT02504827 Phase 4 Ceftazidime/avibactam
48 Pharmacokinetics of Tedizolid Phosphate in Cystic Fibrosis Completed NCT02444234 Phase 4 Tedizolid PO/IV;Tedizolid IV/PO
49 Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients Completed NCT02421120 Phase 4 Ceftolozane/Tazobactam
50 Study to Validate the Instructions for Use of TOBI® Podhaler™ in Cystic Fibrosis Patients Completed NCT02178540 Phase 4 Placebo

Search NIH Clinical Center for Pancreas Disease

Genetic Tests for Pancreas Disease

Genetic tests related to Pancreas Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pancreas 29

Anatomical Context for Pancreas Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Pancreas Disease:

19
The Pancreas

MalaCards organs/tissues related to Pancreas Disease:

41
Pancreas, Lung, Testes, Liver, T Cells, Colon, Bone

Publications for Pancreas Disease

Articles related to Pancreas Disease:

(show top 50) (show all 75)
# Title Authors Year
1
Non-alcoholic fatty pancreas disease (NAFPD): A silent spectator or the fifth component of metabolic syndrome? A literature review. ( 29595117 )
2018
2
Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China. ( 29953011 )
2018
3
Use of Salmon Cardiac Primary Cultures (SCPCs) of different genotypes for comparative kinetics of mx expression, viral load and ultrastructure pathology, after infection with Salmon Pancreas Disease Virus (SPDV). ( 29102629 )
2018
4
Polycystic Pancreas Disease. ( 29287005 )
2017
5
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice. ( 28442507 )
2017
6
The Burden of Systemic Adiposity on Pancreatic Disease: Acute Pancreatitis, Non-Alcoholic Fatty Pancreas Disease, and Pancreatic Cancer. ( 29491829 )
2017
7
Impact of non-alcoholic fatty pancreas disease on glucose metabolism. ( 28371475 )
2017
8
Non-alcoholic fatty pancreas disease. ( 28069746 )
2017
9
Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar). ( 27769313 )
2016
10
The epidemiological and economic effects from systematic depopulation of Norwegian marine salmon farms infected with pancreas disease virus. ( 27664454 )
2016
11
Ballan wrasse (Labrus bergylta Ascanius) is not susceptible to pancreas disease caused by salmonid alphavirus subtype 2 and 3. ( 27859355 )
2016
12
Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease. ( 27678349 )
2016
13
The epidemiology of pancreas disease in salmonid aquaculture: a summary of the current state of knowledge. ( 27136332 )
2016
14
Vaccination against pancreas disease in Atlantic salmon, Salmo salar L., reduces shedding of salmonid alphavirus. ( 27496170 )
2016
15
Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar). ( 25990876 )
2015
16
Comparison of transcriptomic responses to pancreas disease (PD) and heart and skeletal muscle inflammation (HSMI) in heart of Atlantic salmon (Salmo salar L). ( 26232631 )
2015
17
Xenopus as a Model for GI/Pancreas Disease. ( 26236566 )
2015
18
Nonalcoholic fatty pancreas disease and Nonalcoholic fatty liver disease: more than ectopic fat. ( 26201937 )
2015
19
Space-time modelling of the spread of pancreas disease (PD) within and between Norwegian marine salmonid farms. ( 26104836 )
2015
20
Prevalence of Non-Alcoholic Fatty Pancreas Disease (NAFPD) and its risk factors among adult medical check-up patients in a private hospital: a large cross sectional study. ( 26652175 )
2015
21
The economic benefits of disease triggered early harvest: A case study of pancreas disease in farmed Atlantic salmon from Norway. ( 26297077 )
2015
22
An experimental means of transmitting pancreas disease in Atlantic salmon Salmo salar L. fry in freshwater. ( 25297529 )
2014
23
Non-alcoholic fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms. ( 24657938 )
2014
24
Cross-sectional study to investigate the presence of salmon pancreas disease virus in wild and feral fish populations in 10A lakes, Los Lagos Region, Chile. ( 24382013 )
2014
25
Serum enolase: a non-destructive biomarker of white skeletal myopathy during pancreas disease (PD) in Atlantic salmon Salmo salar L. ( 25168106 )
2014
26
Clinical signature and pathogenetic factors of diabetes associated with pancreas disease (T3cDM): a prospective observational study in surgical patients. ( 24974302 )
2014
27
Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population. ( 24572250 )
2014
28
Clinical manifestations of pancreas disease outbreaks in Norwegian marine salmon farming - variations due to salmonid alphavirus subtype. ( 24661057 )
2014
29
Transmission dynamics of pancreas disease (PD) in a Norwegian fjord: aspects of water transport, contact networks and infection pressure among salmon farms. ( 25254274 )
2014
30
Seasonal increase in sea temperature triggers pancreas disease outbreaks in Norwegian salmon farms. ( 23980568 )
2013
31
Immune parameters correlating with reduced susceptibility to pancreas disease in experimentally challenged Atlantic salmon (Salmo salar). ( 23306092 )
2013
32
The association between nonalcoholic fatty pancreas disease and diabetes. ( 23671610 )
2013
33
Transmission dynamics of pancreas disease (PD) in a Norwegian fjord: aspects of water transport, contact networks and infection pressure among salmon farms. ( 23452114 )
2013
34
Mortality related to pancreas disease in Norwegian farmed salmonid fish, Salmo salar L. and Oncorhynchus mykiss (Walbaum). ( 23311767 )
2013
35
Estimation of the reproduction number of salmon pancreas disease virus subtype 3 in homogeneously mixed populations of Norwegian farmed Atlantic salmon. ( 23810623 )
2013
36
Comparative cardiac pathological changes of Atlantic salmon (Salmo salar L.) affected with heart and skeletal muscle inflammation (HSMI), cardiomyopathy syndrome (CMS) and pancreas disease (PD). ( 23200434 )
2013
37
The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3). ( 24145143 )
2013
38
Quality of raw and smoked fillets from clinically healthy Atlantic salmon, Salmo salar L., following an outbreak of pancreas disease (PD). ( 22924617 )
2012
39
Risk map and spatial determinants of pancreas disease in the marine phase of Norwegian Atlantic salmon farming sites. ( 23006469 )
2012
40
Detection of salmon pancreas disease virus in the faeces and mucus of Atlantic salmon, Salmo salar L., by real-time RT-PCR and cell culture following experimental challenge. ( 22924477 )
2012
41
Spleen-derived interleukin-10 downregulates the severity of high-fat diet-induced non-alcoholic fatty pancreas disease. ( 23285260 )
2012
42
Cohort study of effect of vaccination on pancreas disease in Norwegian salmon aquaculture. ( 23209075 )
2012
43
Formulations combining CpG containing oliogonucleotides and poly I:C enhance the magnitude of immune responses and protection against pancreas disease in Atlantic salmon. ( 21527278 )
2011
44
Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease. ( 20170634 )
2010
45
Pancreas disease (PD) in sea-reared Atlantic salmon, Salmo salar L., in Norway; a prospective, longitudinal study of disease development and agreement between diagnostic test results. ( 20609035 )
2010
46
Stochastic modelling of direct costs of pancreas disease (PD) in Norwegian farmed Atlantic salmon (Salmo salar L.). ( 19931201 )
2010
47
Salmonid alphavirus (SAV) and pancreas disease (PD) in Atlantic salmon, Salmo salar L., in freshwater and seawater sites in Norway from 2006 to 2008. ( 20158578 )
2010
48
Detection of salmonid alphavirus RNA in wild marine fish: implications for the origins of salmon pancreas disease in aquaculture. ( 21133318 )
2010
49
A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet. ( 20490316 )
2010
50
Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. ( 20871475 )
2010

Variations for Pancreas Disease

Expression for Pancreas Disease

Search GEO for disease gene expression data for Pancreas Disease.

Pathways for Pancreas Disease

GO Terms for Pancreas Disease

Cellular components related to Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 AVP CCK CELA1 DPP4 GCG IGF1
2 extracellular space GO:0005615 9.47 AVP CCK CELA1 CELA3B GCG IGF1
3 secretory granule lumen GO:0034774 9.33 GCG INS POMC

Biological processes related to Pancreas Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 AVP GCG IGF1 INS LEP
2 G-protein coupled receptor signaling pathway GO:0007186 9.92 AVP CCK GCG INS POMC PPY
3 positive regulation of cell proliferation GO:0008284 9.85 AVP CCK DPP4 IGF1 INS LEP
4 cell-cell signaling GO:0007267 9.8 AVP INS POMC PPY SST
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 CCK IGF1 INS
6 response to insulin GO:0032868 9.71 IGF1 INS LEP
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 IGF1 INS LEP
8 response to nutrient levels GO:0031667 9.65 IGF1 INS LEP
9 response to heat GO:0009408 9.61 IGF1 SST TRPV1
10 positive regulation of glycolytic process GO:0045821 9.59 IGF1 INS
11 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.58 AVP IGF1
12 positive regulation of glycogen biosynthetic process GO:0045725 9.58 IGF1 INS
13 glucose homeostasis GO:0042593 9.56 IGF1 INS LEP POMC
14 regulation of appetite GO:0032098 9.55 POMC PPY
15 negative regulation of appetite GO:0032099 9.52 CCK LEP
16 positive regulation of glutamate secretion GO:0014049 9.49 AVP CCK
17 bone mineralization involved in bone maturation GO:0035630 9.46 IGF1 LEP
18 positive regulation of insulin receptor signaling pathway GO:0046628 9.33 IGF1 INS LEP
19 regulation of signaling receptor activity GO:0010469 9.32 AVP CCK GCG IGF1 INS LEP
20 regulation of insulin secretion GO:0050796 9.26 ABCC8 DPP4 GCG LEP

Molecular functions related to Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.85 CELA1 CELA3B DPP4 PRSS1 PRSS58
2 signaling receptor binding GO:0005102 9.73 AVP DPP4 GCG LEP POMC SCT
3 serine-type endopeptidase activity GO:0004252 9.72 CELA1 CELA3B DPP4 PRSS1 PRSS58
4 G-protein coupled receptor binding GO:0001664 9.61 POMC PPY SCT
5 serine-type peptidase activity GO:0008236 9.55 CELA1 CELA3B DPP4 PRSS1 PRSS58
6 insulin-like growth factor receptor binding GO:0005159 9.48 IGF1 INS
7 glucose:sodium symporter activity GO:0005412 9.4 SLC5A2 SLC5A4
8 receptor activator activity GO:0030546 9.37 IGF1 INS
9 hormone activity GO:0005179 9.32 AVP CCK GCG IGF1 INS LEP
10 neuropeptide hormone activity GO:0005184 9.26 AVP CCK POMC PPY

Sources for Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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