MCID: PNC009
MIFTS: 30

Pancreas Sarcoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreas Sarcoma

MalaCards integrated aliases for Pancreas Sarcoma:

Name: Pancreas Sarcoma 12 15
Sarcoma of Pancreas 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1796
NCIt 50 C5715
UMLS 70 C1096346

Summaries for Pancreas Sarcoma

Disease Ontology : 12 A pancreatic cancer that is located in the pancreas and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Pancreas Sarcoma, also known as sarcoma of pancreas, is related to spindle cell sarcoma and malignant fibrous histiocytoma. An important gene associated with Pancreas Sarcoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Mitotic G1-G1/S phases. Affiliated tissues include pancreas, bone and skin, and related phenotypes are liver/biliary system and neoplasm

Related Diseases for Pancreas Sarcoma

Diseases related to Pancreas Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 29.8 SERPINA3 MDM2
2 malignant fibrous histiocytoma 28.9 SERPINA3 MDM2 DDIT3 CDK4 CD68
3 malignant mesenchymoma 10.2 SERPINA3 MDM2
4 heart cancer 10.2 SERPINA3 MDM2
5 male reproductive organ benign neoplasm 10.1 SERPINA3 CDKN2A
6 smooth muscle tumor 10.1 SERPINA3 HMGA2
7 ossifying fibroma 10.1 SERPINA3 MDM2
8 ring chromosome 7 10.1 MDM2 CDK4
9 congenital epulis 10.1 SERPINA3 CD68
10 epulis 10.1 SERPINA3 CD68
11 verruciform xanthoma of skin 10.1 SERPINA3 CD68
12 gastric liposarcoma 10.1 MDM2 CDK4
13 proliferative fasciitis 10.1 SERPINA3 CD68
14 esophagus verrucous carcinoma 10.1 MDM2 CDKN2A
15 verrucous carcinoma 10.1 MDM2 CDKN2A
16 reticulohistiocytic granuloma 10.1 SERPINA3 CD68
17 xanthogranulomatous pyelonephritis 10.1 SERPINA3 CD68
18 diffuse lipomatosis 10.1 MDM2 CDK4
19 lipoblastoma 10.1 MDM2 CDK4
20 sarcomatoid squamous cell skin carcinoma 10.1 SERPINA3 CD68
21 inflammatory liposarcoma 10.1 MDM2 CDKN2A
22 hemangiopericytoma, malignant 10.1 SERPINA3 MDM2
23 liposarcoma of bone 10.1 MDM2 CDK4
24 multicentric reticulohistiocytosis 10.1 SERPINA3 CD68
25 adult liposarcoma 10.1 MDM2 CDK4
26 malignant granular cell myoblastoma 10.1 SERPINA3 CD68
27 juxtacortical osteosarcoma 10.1 MDM2 CDK4
28 xanthogranulomatous cholecystitis 10.1 SERPINA3 CD68
29 peripheral osteosarcoma 10.1 MDM2 CDK4
30 retroperitoneal sarcoma 10.1 MDM2 CDK4
31 parameningeal embryonal rhabdomyosarcoma 10.1 MDM2 CDK4
32 histiocytic and dendritic cell cancer 10.1 SERPINA3 CD68
33 chondroid lipoma 10.1 HMGA2 CD68
34 ovarian brenner tumor 10.1 MDM2 CDKN2A
35 spindle cell lipoma 10.1 MDM2 CDK4
36 non-langerhans-cell histiocytosis 10.1 SERPINA3 CD68
37 giant cell reparative granuloma 10.1 SERPINA3 CD68
38 malignant spiradenoma 10.1 MDM2 CDKN2A
39 myositis ossificans 10.1 MDM2 CDK4
40 adult xanthogranuloma 10.1 SERPINA3 CD68
41 bladder sarcoma 10.1 SERPINA3 CD68
42 central nervous system vasculitis 10.1 SERPINA3 CD68
43 anal squamous cell carcinoma 10.1 MDM2 CDKN2A
44 bone benign neoplasm 10.1 SERPINA3 CD68
45 pigmented villonodular synovitis 10.1 SERPINA3 CD68
46 bronchopneumonia 10.1 SERPINA3 CD68
47 pseudosarcomatous fibromatosis 10.1 SERPINA3 CD68
48 cutaneous fibrous histiocytoma 10.1 SERPINA3 CD68
49 histiocytosis-lymphadenopathy plus syndrome 10.1 SERPINA3 CD68
50 tonsil cancer 10.1 SERPINA3 CDKN2A

Graphical network of the top 20 diseases related to Pancreas Sarcoma:



Diseases related to Pancreas Sarcoma

Symptoms & Phenotypes for Pancreas Sarcoma

MGI Mouse Phenotypes related to Pancreas Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.35 AFP CDK4 CDKN2A DDIT3 MDM2
2 neoplasm MP:0002006 9.02 AFP CDK4 CDKN2A DDIT3 MDM2

Drugs & Therapeutics for Pancreas Sarcoma

Search Clinical Trials , NIH Clinical Center for Pancreas Sarcoma

Genetic Tests for Pancreas Sarcoma

Anatomical Context for Pancreas Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Pancreas Sarcoma:

19
Pancreas

MalaCards organs/tissues related to Pancreas Sarcoma:

40
Pancreas, Bone, Skin, Liver, Breast, Heart, Smooth Muscle

Publications for Pancreas Sarcoma

Articles related to Pancreas Sarcoma:

# Title Authors PMID Year
1
Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates. 61
29955231 2018
2
Monoclonal antibodies for immunodectection of fibrin deposits on cancer cells. 61
23371915 2013
3
Multidisciplinary cancer care with a patient and physician satisfaction focus. 61
21358949 2010
4
[Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions]. 61
20646423 2010
5
IPdR: a novel oral radiosensitizer. 61
17714027 2007
6
Autosomal-dominant polycystic kidney disease: high prevalence of graft loss for death-related malignancies and cardiovascular risk factors. 61
12962769 2003
7
Granulocytic sarcoma of the pancreas successfully treated with intensive chemotherapy and stem cell transplantation. 61
12605665 2003

Variations for Pancreas Sarcoma

Expression for Pancreas Sarcoma

Search GEO for disease gene expression data for Pancreas Sarcoma.

Pathways for Pancreas Sarcoma

GO Terms for Pancreas Sarcoma

Cellular components related to Pancreas Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 8.96 HMGA2 DDIT3
2 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Pancreas Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.67 HMGA2 DDIT3 CDKN2A CDK4
2 negative regulation of transcription, DNA-templated GO:0045892 9.56 MDM2 HMGA2 DDIT3 CDKN2A
3 protein destabilization GO:0031648 9.48 MDM2 CDKN2A
4 positive regulation of cell cycle GO:0045787 9.46 MDM2 CDK4
5 positive regulation of cell cycle arrest GO:0071158 9.43 HMGA2 CDKN2A
6 negative regulation of DNA binding GO:0043392 9.4 HMGA2 DDIT3
7 negative regulation of cell cycle arrest GO:0071157 9.32 MDM2 CDK4
8 positive regulation of cellular senescence GO:2000774 9.16 HMGA2 CDKN2A
9 amyloid fibril formation GO:1990000 8.96 MDM2 CDKN2A
10 senescence-associated heterochromatin focus assembly GO:0035986 8.62 HMGA2 CDKN2A

Molecular functions related to Pancreas Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.33 HMGA2 DDIT3 CDKN2A
2 disordered domain specific binding GO:0097718 8.96 MDM2 CDKN2A
3 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Pancreas Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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