MCID: PNC009
MIFTS: 25

Pancreas Sarcoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreas Sarcoma

MalaCards integrated aliases for Pancreas Sarcoma:

Name: Pancreas Sarcoma 12 15
Sarcoma of Pancreas 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1796
NCIt 49 C5715
UMLS 71 C1096346

Summaries for Pancreas Sarcoma

Disease Ontology : 12 A pancreatic cancer that is located in the pancreas and that arises from transformed cells of mesenchymal origin.

MalaCards based summary : Pancreas Sarcoma, also known as sarcoma of pancreas, is related to spindle cell sarcoma and fibrous histiocytoma. An important gene associated with Pancreas Sarcoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Transcriptional misregulation in cancer and ATF-2 transcription factor network. Affiliated tissues include pancreas, bone and skin.

Related Diseases for Pancreas Sarcoma

Diseases related to Pancreas Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 29.9 SERPINA3 MDM2
2 fibrous histiocytoma 29.8 SERPINA3 CD68
3 histiocytoma 28.4 SERPINA3 MDM2 CDK4 CD68
4 malignant fibroxanthoma 27.3 SERPINA3 MDM2 HMGA2 DDIT3 CDK4 CD68
5 mixed hepatoblastoma 10.3 SERPINA3 PTER
6 skin tag 10.2 SERPINA3 PTER
7 congenital epulis 10.2 SERPINA3 CD68
8 epulis 10.2 SERPINA3 CD68
9 proliferative fasciitis 10.2 SERPINA3 CD68
10 verruciform xanthoma of skin 10.2 SERPINA3 CD68
11 xanthogranulomatous pyelonephritis 10.2 SERPINA3 CD68
12 reticulohistiocytic granuloma 10.2 SERPINA3 CD68
13 malignant granular cell myoblastoma 10.2 SERPINA3 CD68
14 xanthogranulomatous cholecystitis 10.2 SERPINA3 CD68
15 liver sarcoma 10.2 SERPINA3 CD68
16 multicentric reticulohistiocytosis 10.2 SERPINA3 CD68
17 histiocytic and dendritic cell cancer 10.2 SERPINA3 CD68
18 non-langerhans-cell histiocytosis 10.2 SERPINA3 CD68
19 tenosynovial giant cell tumor 10.2 SERPINA3 CD68
20 malignant spindle cell melanoma 10.1 SERPINA3 CD68
21 dermis tumor 10.1 SERPINA3 CD68
22 giant cell reparative granuloma 10.1 SERPINA3 CD68
23 central nervous system vasculitis 10.1 SERPINA3 CD68
24 pseudosarcomatous fibromatosis 10.1 SERPINA3 CD68
25 cutaneous fibrous histiocytoma 10.1 SERPINA3 CD68
26 malignant mesenchymoma 10.1 SERPINA3 MDM2
27 bone giant cell tumor 10.1 SERPINA3 CD68
28 pigmented villonodular synovitis 10.1 SERPINA3 CD68
29 heart cancer 10.1 SERPINA3 MDM2
30 granular cell tumor 10.1 SERPINA3 CD68
31 ossifying fibroma 10.0 SERPINA3 MDM2
32 chondroid lipoma 10.0 HMGA2 CD68
33 cardiovascular cancer 10.0 SERPINA3 CD68
34 vascular cancer 10.0 SERPINA3 CD68
35 smooth muscle tumor 10.0 SERPINA3 HMGA2
36 reticulosarcoma 10.0 SERPINA3 CD68
37 hemangiopericytoma, malignant 10.0 SERPINA3 MDM2
38 heart leiomyosarcoma 10.0 MDM2 CD68
39 reproductive organ benign neoplasm 10.0 SERPINA3 HMGA2
40 nodular tenosynovitis 10.0 SERPINA3 PTER CD68
41 sarcoma 9.9
42 conventional fibrosarcoma 9.9 MDM2 CD68
43 skin benign neoplasm 9.9 SERPINA3 CD68
44 mesenchymal cell neoplasm 9.8 SERPINA3 HMGA2 CD68
45 soft tissue sarcoma 9.8
46 undifferentiated pleomorphic sarcoma 9.8
47 hypersensitivity reaction type iv disease 9.8 SERPINA3 CD68
48 ring chromosome 7 9.8 MDM2 CDK4
49 mediastinum liposarcoma 9.8 MDM2 CDK4
50 gastric liposarcoma 9.8 MDM2 CDK4

Graphical network of the top 20 diseases related to Pancreas Sarcoma:



Diseases related to Pancreas Sarcoma

Symptoms & Phenotypes for Pancreas Sarcoma

Drugs & Therapeutics for Pancreas Sarcoma

Search Clinical Trials , NIH Clinical Center for Pancreas Sarcoma

Genetic Tests for Pancreas Sarcoma

Anatomical Context for Pancreas Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Pancreas Sarcoma:

19
Pancreas

MalaCards organs/tissues related to Pancreas Sarcoma:

40
Pancreas, Bone, Skin, Heart, Liver, Breast, Kidney

Publications for Pancreas Sarcoma

Articles related to Pancreas Sarcoma:

# Title Authors PMID Year
1
Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates. 61
29955231 2018
2
Monoclonal antibodies for immunodectection of fibrin deposits on cancer cells. 61
23371915 2013
3
Multidisciplinary cancer care with a patient and physician satisfaction focus. 61
21358949 2010
4
[Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions]. 61
20646423 2010
5
IPdR: a novel oral radiosensitizer. 61
17714027 2007
6
Autosomal-dominant polycystic kidney disease: high prevalence of graft loss for death-related malignancies and cardiovascular risk factors. 61
12962769 2003
7
Granulocytic sarcoma of the pancreas successfully treated with intensive chemotherapy and stem cell transplantation. 61
12605665 2003

Variations for Pancreas Sarcoma

Expression for Pancreas Sarcoma

Search GEO for disease gene expression data for Pancreas Sarcoma.

Pathways for Pancreas Sarcoma

Pathways related to Pancreas Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 MDM2 HMGA2 DDIT3
2 11.06 DDIT3 CDK4
3 10.92 MDM2 CDK4
4 10.8 MDM2 CDK4
5 10.46 MDM2 CDK4

GO Terms for Pancreas Sarcoma

Cellular components related to Pancreas Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-DNA complex GO:0032993 8.62 HMGA2 DDIT3

Biological processes related to Pancreas Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.16 MDM2 CDK4
2 negative regulation of DNA binding GO:0043392 8.96 HMGA2 DDIT3
3 negative regulation of cell cycle arrest GO:0071157 8.62 MDM2 CDK4

Sources for Pancreas Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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