MCID: PNC127
MIFTS: 34

Pancreatic Adenosquamous Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Adenosquamous Carcinoma

MalaCards integrated aliases for Pancreatic Adenosquamous Carcinoma:

Name: Pancreatic Adenosquamous Carcinoma 12 15 17
Adenosquamous Carcinoma of the Pancreas 12
Adenosquamous Carcinoma of Pancreas 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5637
NCIt 50 C5721
UMLS 70 C1335299

Summaries for Pancreatic Adenosquamous Carcinoma

Disease Ontology : 12 A pancreatic ductal carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Pancreatic Adenosquamous Carcinoma, also known as adenosquamous carcinoma of the pancreas, is related to adenosquamous carcinoma and mucoepidermoid carcinoma. An important gene associated with Pancreatic Adenosquamous Carcinoma is UPF1 (UPF1 RNA Helicase And ATPase), and among its related pathways/superpathways are Viral mRNA Translation and Gene Expression. The drugs Fluorouracil and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, salivary gland and spleen, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pancreatic Adenosquamous Carcinoma

Diseases related to Pancreatic Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 31.6 MAML2 CRTC1 CDKN2A
2 mucoepidermoid carcinoma 30.3 MAML2 CRTC3 CRTC1 CDKN2A
3 rare tumor 10.5
4 pancreatic cancer 10.4
5 pancreatic ductal adenocarcinoma 10.4
6 pancreatic adenocarcinoma 10.3
7 lacrimal gland mucoepidermoid carcinoma 10.3 MAML2 CRTC1
8 schneiderian carcinoma 10.3 MAML2 CRTC1
9 cutaneous mucoepidermoid carcinoma 10.3 MAML2 CRTC1
10 breast mucoepidermoid carcinoma 10.3 MAML2 CRTC1
11 lung adenoid cystic carcinoma 10.3 MAML2 CRTC1
12 adenocarcinoma 10.3
13 bile duct mucoepidermoid carcinoma 10.2 MAML2 CRTC1
14 endobronchial lipoma 10.2 MAML2 CRTC1
15 warthin tumor 10.2 MAML2 CRTC3 CRTC1
16 clear cell hidradenoma 10.2 MAML2 CRTC3 CRTC1
17 hidradenoma 10.2 MAML2 CRTC3 CRTC1
18 pleomorphic adenoma 10.2 MAML2 CRTC1 CDKN2A
19 cervical adenosquamous carcinoma 10.2 MAML2 CRTC1
20 pleomorphic adenoma carcinoma 10.2 MAML2 CRTC3 CRTC1
21 tonsil cancer 10.2 MAML2 CRTC1 CDKN2A
22 oropharynx cancer 10.2 MAML2 CRTC1 CDKN2A
23 keratinizing squamous cell carcinoma 10.2 MAML2 CDKN2A
24 salivary gland disease 10.2 MAML2 CRTC3 CRTC1
25 splenomegaly 10.2
26 human t-cell leukemia virus type 1 10.1 CRTC3 CRTC1
27 squamous cell papilloma 10.1
28 duodenal ulcer 10.1
29 papilloma 10.1
30 acinar cell carcinoma 10.1
31 tubular adenocarcinoma 10.1
32 sweat gland benign neoplasm 10.1 MAML2 CRTC1
33 salivary gland carcinoma 10.1 MAML2 CRTC3 CRTC1 CDKN2A
34 gastrointestinal stromal tumor 10.1
35 back pain 10.1
36 esophageal cancer 10.0
37 neutrophilia, hereditary 10.0
38 pancreatic agenesis 1 10.0
39 tumor predisposition syndrome 10.0
40 cutaneous telangiectasia and cancer syndrome, familial 10.0
41 panniculitis 10.0
42 splenic abscess 10.0
43 pancreas disease 10.0
44 47,xyy 10.0
45 inherited cancer-predisposing syndrome 10.0
46 metaphyseal chondrodysplasia, schmid type 9.9 UPF3B UPF3A UPF2 SMG9
47 thrombocytopenia-absent radius syndrome 9.9 UPF3A UPF2
48 murray valley encephalitis 9.9 SMG7 PNRC2
49 ullrich congenital muscular dystrophy 1 9.8 UPF3A UPF1 SMG7 SMG5 SMG1

Graphical network of the top 20 diseases related to Pancreatic Adenosquamous Carcinoma:



Diseases related to Pancreatic Adenosquamous Carcinoma

Symptoms & Phenotypes for Pancreatic Adenosquamous Carcinoma

GenomeRNAi Phenotypes related to Pancreatic Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.5 SMG1
2 Decreased viability GR00221-A-1 9.5 CDKN2A MAP3K14 SMG1 SMG6
3 Decreased viability GR00221-A-2 9.5 MAP3K14 SMG6
4 Decreased viability GR00221-A-3 9.5 CDKN2A SMG6
5 Decreased viability GR00221-A-4 9.5 CDKN2A MAP3K14 SMG1
6 Decreased viability GR00342-S-1 9.5 SMG1
7 Decreased viability GR00342-S-3 9.5 SMG1
8 Decreased viability GR00402-S-2 9.5 SMG1

MGI Mouse Phenotypes related to Pancreatic Adenosquamous Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.4 CDKN2A CRTC3 FSD1L HELZ MAP3K14 SMG1

Drugs & Therapeutics for Pancreatic Adenosquamous Carcinoma

Drugs for Pancreatic Adenosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3 51-21-8 3385
2
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
3
Irinotecan Approved, Investigational Phase 3 100286-90-6, 97682-44-5 60838
4
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
5
leucovorin Approved Phase 3 58-05-9 6006
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7 Vitamin B9 Phase 3
8 Antidotes Phase 3
9 Nutrients Phase 3
10 topoisomerase I inhibitors Phase 3
11 Trace Elements Phase 3
12 Micronutrients Phase 3
13 Protective Agents Phase 3
14 Immunosuppressive Agents Phase 3
15 Vitamins Phase 3
16 Vitamin B Complex Phase 3
17 Immunologic Factors Phase 3
18 Folate Phase 3
19 Antimetabolites Phase 3
20 Calcium, Dietary Phase 3
21 Hormones Phase 3
22
Calcium Nutraceutical Phase 3 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Trial of Perioperative Versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer Recruiting NCT04340141 Phase 3 Oxaliplatin;Irinotecan Hydrochloride;Leucovorin Calcium;Fluorouracil

Search NIH Clinical Center for Pancreatic Adenosquamous Carcinoma

Genetic Tests for Pancreatic Adenosquamous Carcinoma

Anatomical Context for Pancreatic Adenosquamous Carcinoma

MalaCards organs/tissues related to Pancreatic Adenosquamous Carcinoma:

40
Pancreas, Salivary Gland, Spleen

Publications for Pancreatic Adenosquamous Carcinoma

Articles related to Pancreatic Adenosquamous Carcinoma:

(show top 50) (show all 114)
# Title Authors PMID Year
1
Use of ring-enhancement and focal necrosis to differentiate pancreatic adenosquamous carcinoma from pancreatic ductal adenocarcinoma on CT and MRI. 61
33387918 2021
2
PD-L1 expression and surgical outcomes of adenosquamous carcinoma of the pancreas in a single-centre study of 56 lesions. 61
33773917 2021
3
Clinical and Histological Basis of Adenosquamous Carcinoma of the Pancreas: A 30-year Experience. 61
33190924 2021
4
Pancreatic panniculitis in a patient with pancreatic adenosquamous carcinoma. 61
33124679 2021
5
Clinical presentation and prognosis of adenosquamous carcinoma of the pancreas - Matched-pair analysis with pancreatic ductal adenocarcinoma. 61
33622577 2021
6
The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma. 61
33404013 2021
7
[A Case of Advanced Adenosquamous Carcinoma of Pancreas with Conversion Surgery after Chemoradiotherapy Followed by Systemic Chemotherapy]. 61
33468978 2020
8
The importance of multimodal therapy in the management of nonmetastatic adenosquamous carcinoma of the pancreas: Analysis of treatment sequence and strategy. 61
33376004 2020
9
Adenosquamous carcinoma of the pancreas. 61
32107164 2020
10
Pancreatic adenosquamous carcinoma with invasion to the spleen in a cat. 61
32655098 2020
11
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. 61
32928922 2020
12
[Radical Resection of a Locally Advanced Unresectable Pancreatic Adenosquamous Carcinoma after Treatment with Systemic Chemotherapy]. 61
32829362 2020
13
Cellular organization and histogenesis of adenosquamous carcinoma of the pancreas: evidence supporting the squamous metaplasia concept. 61
32170368 2020
14
An autopsy case of granulocyte colony-stimulating factor-producing pancreatic adenosquamous carcinoma. 61
31734879 2020
15
Adenosquamous Carcinoma of the Pancreas Comprise a Heterogeneous Group of Tumors With the Worst Outcome: A Clinicopathological Analysis of 25 Cases Identified in 562 Pancreatic Carcinomas Resected With Curative Intent. 61
32433407 2020
16
Primary non-ampullary duodenal follicular lymphoma presenting with obstructive jaundice. 61
31401784 2020
17
18F-FDG PET/CT feature of pancreatic adenosquamous carcinoma with pathological correlation. 61
31907569 2020
18
Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature. 61
31587324 2020
19
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report. 61
31941506 2020
20
Computed Tomography-Based Radiomics Signature for the Preoperative Differentiation of Pancreatic Adenosquamous Carcinoma From Pancreatic Ductal Adenocarcinoma. 61
32984030 2020
21
Identification of germline and somatic mutations in pancreatic adenosquamous carcinoma using whole exome sequencing. 61
31958074 2020
22
Dissecting the presence of malignant squamous cells in pancreatic cytopathology: A case series. 61
31407529 2019
23
[A Case of Borderline Resectable Pancreatic Adenosquamous Carcinoma Achieving Pathological Complete Response]. 61
32156953 2019
24
[A Case of Locally Advanced Adenosquamous Carcinoma of the Pancreas Accompanied by Hepatic Metastasis Treated by Resection of the Primary Lesion as Palliative Care]. 61
32156878 2019
25
Chemoradiotherapy is associated with improved survival for resected pancreatic adenosquamous carcinoma: a retrospective cohort study from the SEER database. 61
31807504 2019
26
Long-term outcomes after an aggressive resection of adenosquamous carcinoma of the pancreas. 61
30980180 2019
27
CT and MR imaging features of pancreatic adenosquamous carcinoma and their correlation with prognosis. 61
31187197 2019
28
Sarcomatous Component in Pancreatic Adenosquamous Carcinoma: A Clinicopathological Series of 7 Cases. 61
31366562 2019
29
Two rare cases of pancreatic adenosquamous carcinoma: A review of the literature with focus on radiologic findings. 61
31194122 2019
30
Pancreatic adenosquamous carcinoma masquerading as a locally invading splenic abscess. 61
29740918 2019
31
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features: Erratum. 61
30985334 2019
32
Adenosquamous Carcinoma of the Pancreas. 61
31723321 2019
33
[A Case of Resection of Advanced Pancreatic Adenosquamous Carcinoma in which Multidisciplinary Treatment Was Effective]. 61
30765680 2019
34
PD-L1 expression in pancreatic adenosquamous carcinoma: PD-L1 expression is limited to the squamous component. 61
30477643 2018
35
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features. 61
30138216 2018
36
Comparative outcomes of adenosquamous carcinoma of the pancreas: An analysis of the National Cancer Database. 61
29878370 2018
37
A retroperitoneal mass confirmed as a pancreatic adenosquamous carcinoma by endoscopic ultrasound-guided fine-needle aspiration. 61
29069702 2018
38
Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas. 61
28816351 2017
39
Angiogenesis in adenosquamous cancer of pancreas. 61
29221165 2017
40
Genomic signatures of pancreatic adenosquamous carcinoma (PASC). 61
28722109 2017
41
Clinical implications of the proliferative ability of the squamous component regarding tumor progression of adenosquamous carcinoma of the pancreas: A preliminary report. 61
28784574 2017
42
Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in a CDKN2A germline mutation carrier. 61
28979722 2017
43
Adenosquamous Carcinoma of the Pancreas Demonstrated on 18F-FDG PET/CT Imaging. 61
28098663 2017
44
[Pancreatic Adenosquamous Carcinoma That Developed after Resection of IPMA in the Pancreatic Tail]. 61
28133317 2016
45
A Case of Pancreatic Adenosquamous Carcinoma Obstructing the Common Bile and Pancreatic Ducts, Duodenum, and Gastric Outlet. 61
26863381 2016
46
Nab-paclitaxel+gemcitabine therapy for adenosquamous carcinoma of the pancreas: an autopsy case. 61
27725467 2016
47
Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review. 61
26380056 2015
48
Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas. 61
25830031 2015
49
[The clinico-pathological character of pancreatic adenosquamous carcinoma]. 61
25857012 2015
50
Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. 61
24973941 2015

Variations for Pancreatic Adenosquamous Carcinoma

Expression for Pancreatic Adenosquamous Carcinoma

Search GEO for disease gene expression data for Pancreatic Adenosquamous Carcinoma.

Pathways for Pancreatic Adenosquamous Carcinoma

Pathways related to Pancreatic Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 UPF3B UPF3A UPF2 UPF1 SMG9 SMG7
2
Show member pathways
13.17 UPF3B UPF3A UPF2 UPF1 SMG9 SMG7
3 11.96 MAP3K14 CRTC3 CRTC1 CDKN2A
4 11.83 UPF3B UPF3A UPF2 UPF1
5 11.22 UPF3B UPF3A UPF2 UPF1 SMG7 SMG6

GO Terms for Pancreatic Adenosquamous Carcinoma

Cellular components related to Pancreatic Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.17 UPF3B UPF3A UPF2 UPF1 SMG7 SMG6
2 nucleus GO:0005634 10.1 UPF3B UPF3A UPF2 UPF1 SMG7 SMG6
3 nucleoplasm GO:0005654 10.07 UPF3B UPF3A UPF1 SMG1 PNRC2 MAP3K14
4 cytosol GO:0005829 9.83 UPF3B UPF3A UPF2 UPF1 SMG9 SMG7
5 telomerase holoenzyme complex GO:0005697 9.33 SMG7 SMG6 SMG5
6 exon-exon junction complex GO:0035145 9.02 UPF3B UPF3A UPF2 UPF1 SMG6

Biological processes related to Pancreatic Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA export from nucleus GO:0006406 9.5 UPF3B UPF2 UPF1 SMG7 SMG6 SMG5
2 regulation of telomere maintenance GO:0032204 9.46 UPF1 SMG6 SMG5 SMG1
3 regulation of dephosphorylation GO:0035303 9.43 SMG7 SMG6 SMG5
4 energy homeostasis GO:0097009 9.4 CRTC3 CRTC1
5 positive regulation of CREB transcription factor activity GO:0032793 9.37 CRTC3 CRTC1
6 regulation of telomere maintenance via telomerase GO:0032210 9.32 SMG6 SMG5
7 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 9.32 UPF3B UPF3A UPF2 UPF1 SMG9 SMG7

Molecular functions related to Pancreatic Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.76 UPF3B UPF3A UPF2 UPF1 SMG6 SMG1
2 protein phosphatase 2A binding GO:0051721 9.37 SMG7 SMG5
3 structural constituent of nuclear pore GO:0017056 9.32 UPF3B UPF3A
4 cAMP response element binding protein binding GO:0008140 9.26 CRTC3 CRTC1
5 telomeric DNA binding GO:0042162 9.17 UPF3A UPF2 UPF1 SMG7 SMG6 SMG5
6 telomerase RNA binding GO:0070034 9.13 SMG7 SMG6 SMG5

Sources for Pancreatic Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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