PNCA1
MCID: PNC094
MIFTS: 16

Pancreatic Cancer 1 (PNCA1)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Pancreatic Cancer 1

MalaCards integrated aliases for Pancreatic Cancer 1:

Name: Pancreatic Cancer 1 58 76 30 6
Pancreatic Cancer, Susceptibility to, 1 58 13
Pnca1 58 76
Cancer, Pancreatic, Susceptibility to, Type 1 41

Classifications:



External Ids:

OMIM 58 606856
MeSH 45 D010190
MedGen 43 C1847351

Summaries for Pancreatic Cancer 1

UniProtKB/Swiss-Prot : 76 Pancreatic cancer 1: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 1, is also known as pancreatic cancer, susceptibility to, 1. An important gene associated with Pancreatic Cancer 1 is PALLD (Palladin, Cytoskeletal Associated Protein). The drugs Gemcitabine and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include pancreas.

Description from OMIM: 606856

Related Diseases for Pancreatic Cancer 1

Symptoms & Phenotypes for Pancreatic Cancer 1

Clinical features from OMIM:

606856

Drugs & Therapeutics for Pancreatic Cancer 1

Drugs for Pancreatic Cancer 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
2
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
3 Antimetabolites Phase 1, Phase 2
4 Antimetabolites, Antineoplastic Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Accelerated Short Course Radiation Therapy With Photons and Capecitabine for Resectable Pancreatic Cancer Terminated NCT00889187 Phase 1, Phase 2 Capecitabine

Search NIH Clinical Center for Pancreatic Cancer 1

Genetic Tests for Pancreatic Cancer 1

Genetic tests related to Pancreatic Cancer 1:

# Genetic test Affiliating Genes
1 Pancreatic Cancer 1 30 PALLD

Anatomical Context for Pancreatic Cancer 1

MalaCards organs/tissues related to Pancreatic Cancer 1:

42
Pancreas

Publications for Pancreatic Cancer 1

Variations for Pancreatic Cancer 1

ClinVar genetic disease variations for Pancreatic Cancer 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PALLD NM_001166110.1(PALLD): c.415C> T (p.Pro139Ser) single nucleotide variant risk factor rs121908291 GRCh37 Chromosome 4, 169799457: 169799457
2 PALLD NM_001166110.1(PALLD): c.415C> T (p.Pro139Ser) single nucleotide variant risk factor rs121908291 GRCh38 Chromosome 4, 168878306: 168878306

Expression for Pancreatic Cancer 1

Search GEO for disease gene expression data for Pancreatic Cancer 1.

Pathways for Pancreatic Cancer 1

GO Terms for Pancreatic Cancer 1

Sources for Pancreatic Cancer 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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