MCID: PNC094
MIFTS: 16

Pancreatic Cancer 1

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cancer 1

MalaCards integrated aliases for Pancreatic Cancer 1:

Name: Pancreatic Cancer 1 57 75 29 6
Pancreatic Cancer, Susceptibility to, 1 57 13
Pnca1 57 75
Cancer, Pancreatic, Susceptibility to, Type 1 40

Classifications:



External Ids:

OMIM 57 606856
MedGen 42 C1847351
MeSH 44 D010190

Summaries for Pancreatic Cancer 1

UniProtKB/Swiss-Prot : 75 Pancreatic cancer 1: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 1, is also known as pancreatic cancer, susceptibility to, 1. An important gene associated with Pancreatic Cancer 1 is PALLD (Palladin, Cytoskeletal Associated Protein). The drugs Capecitabine and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include pancreas.

Description from OMIM: 606856

Related Diseases for Pancreatic Cancer 1

Symptoms & Phenotypes for Pancreatic Cancer 1

Clinical features from OMIM:

606856

Drugs & Therapeutics for Pancreatic Cancer 1

Drugs for Pancreatic Cancer 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
2
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
3 Antimetabolites Phase 1, Phase 2
4 Antimetabolites, Antineoplastic Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Accelerated Short Course Radiation Therapy With Photons and Capecitabine for Resectable Pancreatic Cancer Terminated NCT00889187 Phase 1, Phase 2 Capecitabine

Search NIH Clinical Center for Pancreatic Cancer 1

Genetic Tests for Pancreatic Cancer 1

Genetic tests related to Pancreatic Cancer 1:

# Genetic test Affiliating Genes
1 Pancreatic Cancer 1 29 PALLD

Anatomical Context for Pancreatic Cancer 1

MalaCards organs/tissues related to Pancreatic Cancer 1:

41
Pancreas

Publications for Pancreatic Cancer 1

Variations for Pancreatic Cancer 1

ClinVar genetic disease variations for Pancreatic Cancer 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PALLD NM_001166110.1(PALLD): c.415C> T (p.Pro139Ser) single nucleotide variant risk factor rs121908291 GRCh37 Chromosome 4, 169799457: 169799457
2 PALLD NM_001166110.1(PALLD): c.415C> T (p.Pro139Ser) single nucleotide variant risk factor rs121908291 GRCh38 Chromosome 4, 168878306: 168878306

Expression for Pancreatic Cancer 1

Search GEO for disease gene expression data for Pancreatic Cancer 1.

Pathways for Pancreatic Cancer 1

GO Terms for Pancreatic Cancer 1

Sources for Pancreatic Cancer 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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