MCID: PNC111
MIFTS: 15

Pancreatic Cancer 2

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cancer 2

MalaCards integrated aliases for Pancreatic Cancer 2:

Name: Pancreatic Cancer 2 57 75 29 6
Pnca2 57 75
Cancer, Pancreatic, Susceptibility to, Type 2 40
Pancreatic Cancer, Susceptibility to, 2 57

Classifications:



External Ids:

OMIM 57 613347
MedGen 42 C3150546
MeSH 44 D010190
SNOMED-CT via HPO 69 126859007 363418001

Summaries for Pancreatic Cancer 2

UniProtKB/Swiss-Prot : 75 Pancreatic cancer 2: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 2, is also known as pnca2. An important gene associated with Pancreatic Cancer 2 is BRCA2 (BRCA2, DNA Repair Associated). Affiliated tissues include pancreas, and related phenotype is neoplasm of the pancreas.

Description from OMIM: 613347

Related Diseases for Pancreatic Cancer 2

Symptoms & Phenotypes for Pancreatic Cancer 2

Clinical features from OMIM:

613347

Human phenotypes related to Pancreatic Cancer 2:

32
# Description HPO Frequency HPO Source Accession
1 neoplasm of the pancreas 32 HP:0002894

Drugs & Therapeutics for Pancreatic Cancer 2

Search Clinical Trials , NIH Clinical Center for Pancreatic Cancer 2

Genetic Tests for Pancreatic Cancer 2

Genetic tests related to Pancreatic Cancer 2:

# Genetic test Affiliating Genes
1 Pancreatic Cancer 2 29 BRCA2

Anatomical Context for Pancreatic Cancer 2

MalaCards organs/tissues related to Pancreatic Cancer 2:

41
Pancreas

Publications for Pancreatic Cancer 2

Variations for Pancreatic Cancer 2

ClinVar genetic disease variations for Pancreatic Cancer 2:

6
(show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 BRCA2 NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs) deletion Pathogenic rs80359550 GRCh37 Chromosome 13, 32914438: 32914438
2 BRCA2 NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs) deletion Pathogenic rs80359550 GRCh38 Chromosome 13, 32340301: 32340301
3 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh37 Chromosome 13, 32914174: 32914174
4 BRCA2 NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter) single nucleotide variant Pathogenic rs41293497 GRCh38 Chromosome 13, 32340037: 32340037
5 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh37 Chromosome 13, 32930609: 32930609
6 BRCA2 NM_000059.3(BRCA2): c.7480C> T (p.Arg2494Ter) single nucleotide variant Pathogenic rs80358972 GRCh38 Chromosome 13, 32356472: 32356472
7 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh37 Chromosome 13, 32954050: 32954050
8 BRCA2 NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=) single nucleotide variant Pathogenic rs28897756 GRCh38 Chromosome 13, 32379913: 32379913
9 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh37 Chromosome 13, 32893291: 32893291
10 BRCA2 NM_000059.3(BRCA2): c.145G> T (p.Glu49Ter) single nucleotide variant Pathogenic rs80358435 GRCh38 Chromosome 13, 32319154: 32319154
11 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh37 Chromosome 13, 32914349: 32914349
12 BRCA2 NM_000059.3(BRCA2): c.5857G> T (p.Glu1953Ter) single nucleotide variant Pathogenic rs80358814 GRCh38 Chromosome 13, 32340212: 32340212

Expression for Pancreatic Cancer 2

Search GEO for disease gene expression data for Pancreatic Cancer 2.

Pathways for Pancreatic Cancer 2

GO Terms for Pancreatic Cancer 2

Sources for Pancreatic Cancer 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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